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Conserved domains on  [gi|489821793|ref|WP_003725592|]
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MULTISPECIES: phosphatidylglycerophosphatase A [Listeria]

Protein Classification

phosphatidylglycerophosphatase A( domain architecture ID 10161382)

phosphatidylglycerophosphatase A catalyzes formation of phosphatidylglycerol from phosphatidylglycerophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
 12-146 1.09e-24

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


:

Pssm-ID: 133477  Cd Length: 143  Bit Score: 92.99  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821793  12 ARSWLIERGVEIDDIAELVLFLQQkyhpGLELDICRQNVEHVLRkrEVQNAVLTGIQLDVMAEKgelvqPLQNIISADEG 91
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLA----ALPLELLLSELGKVLL--ELLALLLAFLLGIWAAEK-----TLKDLGVHDPG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821793  92 LYGVDEILALSIVNVY-------GSIGFTNYGYIDKVKPGILAKLNEHDGIAVHTFLDDIVG 146
Cdd:cd06971   70 EIVIDEVVGQWIALLIvpfgwlwGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLGVMLDDILA 131
 
Name Accession Description Interval E-value
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
 12-146 1.09e-24

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


Pssm-ID: 133477  Cd Length: 143  Bit Score: 92.99  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821793  12 ARSWLIERGVEIDDIAELVLFLQQkyhpGLELDICRQNVEHVLRkrEVQNAVLTGIQLDVMAEKgelvqPLQNIISADEG 91
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLA----ALPLELLLSELGKVLL--ELLALLLAFLLGIWAAEK-----TLKDLGVHDPG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821793  92 LYGVDEILALSIVNVY-------GSIGFTNYGYIDKVKPGILAKLNEHDGIAVHTFLDDIVG 146
Cdd:cd06971   70 EIVIDEVVGQWIALLIvpfgwlwGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLGVMLDDILA 131
PgpA pfam04608
Phosphatidylglycerophosphatase A; This family represents a family of bacterial ...
 52-146 1.48e-15

Phosphatidylglycerophosphatase A; This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.


Pssm-ID: 461365  Cd Length: 136  Bit Score: 69.15  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821793   52 HVLRKREVQNAVLTGIQLDVMAEKGELVQPLQNIISADEGLYGVDEILALSIVNVY-GSIGFTNYGYIDKVKPGILAKLN 130
Cdd:pfam04608  30 LVLSKPLSLILLLVALLLLFLLGIYAADKAEKDLGKKDPGEIVIDEVLGQLIALLFlLLAGFVLFRFFDILKPWPISKLD 109

                          90
                  ....*....|....*.
gi 489821793  131 EHDGiAVHTFLDDIVG 146
Cdd:pfam04608 110 RLPG-GWGVMLDDILA 124
 
Name Accession Description Interval E-value
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
 12-146 1.09e-24

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


Pssm-ID: 133477  Cd Length: 143  Bit Score: 92.99  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821793  12 ARSWLIERGVEIDDIAELVLFLQQkyhpGLELDICRQNVEHVLRkrEVQNAVLTGIQLDVMAEKgelvqPLQNIISADEG 91
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLA----ALPLELLLSELGKVLL--ELLALLLAFLLGIWAAEK-----TLKDLGVHDPG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821793  92 LYGVDEILALSIVNVY-------GSIGFTNYGYIDKVKPGILAKLNEHDGIAVHTFLDDIVG 146
Cdd:cd06971   70 EIVIDEVVGQWIALLIvpfgwlwGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLGVMLDDILA 131
PgpA pfam04608
Phosphatidylglycerophosphatase A; This family represents a family of bacterial ...
 52-146 1.48e-15

Phosphatidylglycerophosphatase A; This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.


Pssm-ID: 461365  Cd Length: 136  Bit Score: 69.15  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821793   52 HVLRKREVQNAVLTGIQLDVMAEKGELVQPLQNIISADEGLYGVDEILALSIVNVY-GSIGFTNYGYIDKVKPGILAKLN 130
Cdd:pfam04608  30 LVLSKPLSLILLLVALLLLFLLGIYAADKAEKDLGKKDPGEIVIDEVLGQLIALLFlLLAGFVLFRFFDILKPWPISKLD 109

                          90
                  ....*....|....*.
gi 489821793  131 EHDGiAVHTFLDDIVG 146
Cdd:pfam04608 110 RLPG-GWGVMLDDILA 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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