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Conserved domains on  [gi|489821838|ref|WP_003725637|]
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MULTISPECIES: GntR family transcriptional regulator [Listeria]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-242 3.50e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 158.87  E-value: 3.50e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   1 MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEevifn 80
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  81 eyttvpngRFNRKTKITNE--------HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSN 151
Cdd:COG2188   77 --------PLSRLTSFTEElrargrepSTRVLSAERVPaDEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAAL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 152 LINVDLTNFERfNSLSEVIKELYGINILHeaMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESY 231
Cdd:COG2188  149 FPGLLEEDLET-GSLYELLEERYGLRITR--AEQRIEAVLA--DAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSY 223

                        250
                 ....*....|.
gi 489821838 232 LRHNFYSIEIE 242
Cdd:COG2188  224 YRGDRYRFVVE 234
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-242 3.50e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 158.87  E-value: 3.50e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   1 MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEevifn 80
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  81 eyttvpngRFNRKTKITNE--------HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSN 151
Cdd:COG2188   77 --------PLSRLTSFTEElrargrepSTRVLSAERVPaDEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAAL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 152 LINVDLTNFERfNSLSEVIKELYGINILHeaMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESY 231
Cdd:COG2188  149 FPGLLEEDLET-GSLYELLEERYGLRITR--AEQRIEAVLA--DAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSY 223

                        250
                 ....*....|.
gi 489821838 232 LRHNFYSIEIE 242
Cdd:COG2188  224 YRGDRYRFVVE 234
PRK11402 PRK11402
transcriptional regulator PhoB;
8-245 2.32e-29

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 110.31  E-value: 2.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   8 IIINDIKRlisdGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYV-SKSIINEEVIFNEYTT-- 84
Cdd:PRK11402  17 RLLDDIAQ----GVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVqSQKVENALLTVSGFTDfg 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  85 VPNGRfNRKTKITnEHTKVVAineiqdARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDlTNFERFN 164
Cdd:PRK11402  93 VSQGK-ATKEKVI-EQERVSA------APFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFD-EIYVEGS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 165 SLSEVIKELYGINILHEamKERIEVEFPVKDKNnfKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIEIEKK 244
Cdd:PRK11402 164 STYQLFQERFDTRVVSD--KKTIDIFAATRPEA--KWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNK 239


                 .
gi 489821838 245 K 245
Cdd:PRK11402 240 R 240
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 100-238 1.57e-20

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 84.27  E-value: 1.57e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   100 HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNFErfNSLSEVIKELYGINI 178
Cdd:smart00866   7 TTKVLSFERVPaDEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLS--GSLYEYLEERLGLKI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489821838   179 LH-EAMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYS 238
Cdd:smart00866  85 VRsTRAEQTITAVLA--DEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 1.62e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 82.11  E-value: 1.62e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821838   4 PKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVS 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 100-238 1.48e-19

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 81.87  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  100 HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKS---NLINVDLTNferfNSLSEVIKELYG 175
Cdd:pfam07702   7 KTEVLSLEEVPaSAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAElvpDLLEEDLEE----GSLYDYLEERYG 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489821838  176 INILHeaMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYS 238
Cdd:pfam07702  83 LPITR--AEQTIEAVLA--DAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-242 3.50e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 158.87  E-value: 3.50e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   1 MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEevifn 80
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  81 eyttvpngRFNRKTKITNE--------HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSN 151
Cdd:COG2188   77 --------PLSRLTSFTEElrargrepSTRVLSAERVPaDEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAAL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 152 LINVDLTNFERfNSLSEVIKELYGINILHeaMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESY 231
Cdd:COG2188  149 FPGLLEEDLET-GSLYELLEERYGLRITR--AEQRIEAVLA--DAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSY 223

                        250
                 ....*....|.
gi 489821838 232 LRHNFYSIEIE 242
Cdd:COG2188  224 YRGDRYRFVVE 234
PRK11402 PRK11402
transcriptional regulator PhoB;
8-245 2.32e-29

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 110.31  E-value: 2.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   8 IIINDIKRlisdGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYV-SKSIINEEVIFNEYTT-- 84
Cdd:PRK11402  17 RLLDDIAQ----GVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVqSQKVENALLTVSGFTDfg 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  85 VPNGRfNRKTKITnEHTKVVAineiqdARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDlTNFERFN 164
Cdd:PRK11402  93 VSQGK-ATKEKVI-EQERVSA------APFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFD-EIYVEGS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 165 SLSEVIKELYGINILHEamKERIEVEFPVKDKNnfKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIEIEKK 244
Cdd:PRK11402 164 STYQLFQERFDTRVVSD--KKTIDIFAATRPEA--KWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTIDNK 239


                 .
gi 489821838 245 K 245
Cdd:PRK11402 240 R 240
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 100-238 1.57e-20

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 84.27  E-value: 1.57e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   100 HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNFErfNSLSEVIKELYGINI 178
Cdd:smart00866   7 TTKVLSFERVPaDEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLS--GSLYEYLEERLGLKI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489821838   179 LH-EAMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYS 238
Cdd:smart00866  85 VRsTRAEQTITAVLA--DEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 1.62e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 82.11  E-value: 1.62e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489821838   4 PKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVS 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 100-238 1.48e-19

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 81.87  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  100 HTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKS---NLINVDLTNferfNSLSEVIKELYG 175
Cdd:pfam07702   7 KTEVLSLEEVPaSAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAElvpDLLEEDLEE----GSLYDYLEERYG 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489821838  176 INILHeaMKERIEVEFPvkDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYS 238
Cdd:pfam07702  83 LPITR--AEQTIEAVLA--DAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK09764 PRK09764
GntR family transcriptional regulator;
2-246 1.82e-16

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 76.02  E-value: 1.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   2 AEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINeevifne 81
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVN------- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  82 YTTVPNGRFNRK--TKITNEHTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSnlINVDLT 158
Cdd:PRK09764  76 YDIFQLTSFDEKlsDRHVDTHSEVLIFEVIPaDDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLA--LFPDLT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 159 NFERFNSLSEVIKELYGINIlheamkERIEVEF-PV-KDKNNFKLLEIDSELPLyhIERIT--YVPEGQPYEYIESYLRH 234
Cdd:PRK09764 154 WQVMENSKYHFIEEVKKMVI------DRSEQEIiPLmPTEEMSRLLNISQTKPI--LEKVSrgYLVDGRVFEYSRNAFNT 225

                        250
                 ....*....|..
gi 489821838 235 NFYSIEIEKKKQ 246
Cdd:PRK09764 226 DDYKFTLIAQRK 237
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 5-68 1.26e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.48  E-value: 1.26e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821838    5 KYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYV 68
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-68 5.69e-14

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 64.52  E-value: 5.69e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838     9 IINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYV 68
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-69 1.33e-13

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 65.20  E-value: 1.33e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489821838   3 EPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVS 69
Cdd:COG1725    9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVA 75
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-69 1.48e-13

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 69.47  E-value: 1.48e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821838   1 MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVS 69
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
6-69 3.91e-11

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 61.10  E-value: 3.91e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821838   6 YAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVS 69
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVR 72
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-144 1.32e-10

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 59.56  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   4 PKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSiINEEVIFnEYT 83
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEP-KGQSALF-EVR 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821838  84 TVPNGRFNRKTKitnEHTKVVAINEIQ-DARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQN 144
Cdd:PRK14999  90 SIAEEIAARRHQ---HRCEVLTLERVRaNAIQASALNVNESDVIFHSIMVHYENDLPVQIED 148
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
3-72 1.49e-10

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 59.65  E-value: 1.49e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489821838   3 EPKYA-IIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSI 72
Cdd:PRK09464   8 QPKLSdVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSL 78
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-69 3.15e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 55.31  E-value: 3.15e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838   1 MAEPKYAIIINDIKRLISDGTFKPGEKIySEDELKKKYNVSnTTVVR-ALHELVRAGILARYQGKGTYVS 69
Cdd:COG1802    8 RRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVS-RTPVReALRRLEAEGLVEIRPNRGARVA 75
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 20-233 9.47e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 51.31  E-value: 9.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838  20 GTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINeevifneYTTVPNGRFNRKTKITNE 99
Cdd:PRK10079  27 QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYD-------YPLNAQARFSQNLLDQGS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 100 H---TKVVAINEIQDARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAksnlinvDLT---NFERFNSLSevikel 173
Cdd:PRK10079 100 HptsEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFA-------DLTwwpTLQRFDSGS------ 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821838 174 yginiLHEAMKERIEVEFPVK---------DKNNFKLLEIDSELPLYHIERI-TYVPEGQPYEYIESYLR 233
Cdd:PRK10079 167 -----LHDFLREQLGIALRRSqtrisarraQAKESQLLEIPNMSPLLCVRTLnHRDGESSPAEYSVSLTR 231
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 13-70 2.10e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 44.37  E-value: 2.10e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489821838  13 IKRLISDGTFKPGEKIYSEDELKKKYNVSNTtvvrALHE---LVRA-GILARYQGKGTYVSK 70
Cdd:PRK09990  16 IERLIVDGVLKVGQALPSERRLCEKLGFSRS----ALREgltVLRGrGIIETAQGRGSFVAR 73
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 13-68 7.38e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 39.75  E-value: 7.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489821838  13 IKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYV 68
Cdd:PRK10421  11 VRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK10225 PRK10225
Uxu operon transcriptional regulator;
13-77 1.07e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 39.23  E-value: 1.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489821838  13 IKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEEV 77
Cdd:PRK10225  18 IRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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