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Conserved domains on  [gi|489821859|ref|WP_003725658|]
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bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Listeria monocytogenes]

Protein Classification

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase( domain architecture ID 11418829)

bifunctional phosphopantothenoylcysteine decarboxylase (CoaC)/phosphopantothenate synthase (CoaB) catalyzes two steps in the biosynthesis of coenzyme A, the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, followed by its decarboxylation to form 4'-phosphopantotheine

EC:  4.1.1.36|6.3.2.5
Gene Ontology:  GO:0071513|GO:0010181|GO:0046872|GO:0004632|GO:0004633|GO:0015937|GO:0015941

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 1-399 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 661.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA 80
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 161 RGRLEEPEKIVLRIAEFFQEDKDLlRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPKKDL-AGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 241 VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV 320
Cdd:COG0452  241 TPAGVERIDVESAEEMLEAVLAAFPDADIVIMAAAVADYRPAEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFL 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821859 321 IGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK 399
Cdd:COG0452  321 VGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAELLAA 399
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 1-399 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 661.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA 80
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 161 RGRLEEPEKIVLRIAEFFQEDKDLlRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPKKDL-AGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 241 VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV 320
Cdd:COG0452  241 TPAGVERIDVESAEEMLEAVLAAFPDADIVIMAAAVADYRPAEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFL 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821859 321 IGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK 399
Cdd:COG0452  321 VGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-399 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 562.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA 80
Cdd:PRK05579   4 LAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELAKWA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:PRK05579  84 DLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACGDVG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 161 RGRLEEPEKIVLRIAEFFQeDKDlLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:PRK05579 164 PGRMAEPEEIVAAAERALS-PKD-LAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNLP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 241 VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV 320
Cdd:PRK05579 242 TPAGVKRIDVESAQEMLDAVLAALPQADIFIMAAAVADYRPATVAEGKIKKGEGELTLELVPNPDILAEVAALKDKRPFV 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821859 321 IGFAAETENLEANARKKLTSKNADMIVANNISvAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK 399
Cdd:PRK05579 322 VGFAAETGDVLEYARAKLKRKGLDLIVANDVS-AGGGFGSDDNEVTLIWSDGGEVKLPLMSKLELARRLLDEIAERLLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 1-392 2.73e-161

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 458.37  E-value: 2.73e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859    1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVaHIDLADWA 80
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  161 RGRLEEPEKIVLRIAEFFQEDKDlLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFSPKED-LEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  241 VPPGVEAIYVESAEEMYQAVDEHKVS-QDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTaDQV 319
Cdd:TIGR00521 239 TPPGVKSIKVSTAEEMLEAALNELAKdFDIFISAAAVADFKPKTVFEGKIKKQGEELSLKLVKNPDIIAEVRKIKK-HQV 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821859  320 VIGFAAETEN-LEANARKKLTSKNADMIVANNISVaGAGFSGDTNIVTFYRKDGsSKALPILDKKEVAEHIIKE 392
Cdd:TIGR00521 318 IVGFKAETNDdLIKYAKEKLKKKNLDMIVANDVSQ-GRGFGSDENEVYIFSKHG-HKELPLMSKLEVAERILDE 389
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 185-366 2.29e-97

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 288.15  E-value: 2.29e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  185 LRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALPVPPGVEAIYVESAEEMYQAVDEHK 264
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  265 VSQDIFVMTAAVADYTPAKVSDQKIKKQPGD--FAIEMKRTKDILLEIGQHKTaDQVVIGFAAETENLEANARKKLTSKN 342
Cdd:pfam04127  81 PEADIVIMAAAVADYRPAEVADGKIKKSSGGeeLTLELVKNPDILAELGKRKP-GQLLVGFAAETEDLLENARAKLERKN 159

                         170       180
                  ....*....|....*....|....
gi 489821859  343 ADMIVANNISVAGAGFSGDTNIVT 366
Cdd:pfam04127 160 LDLIVANDVSRPGAGFGSDTNEVT 183
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 1-399 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 661.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA 80
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 161 RGRLEEPEKIVLRIAEFFQEDKDLlRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPKKDL-AGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 241 VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV 320
Cdd:COG0452  241 TPAGVERIDVESAEEMLEAVLAAFPDADIVIMAAAVADYRPAEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFL 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821859 321 IGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK 399
Cdd:COG0452  321 VGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAELLAA 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-399 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 562.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA 80
Cdd:PRK05579   4 LAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELAKWA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:PRK05579  84 DLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACGDVG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 161 RGRLEEPEKIVLRIAEFFQeDKDlLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:PRK05579 164 PGRMAEPEEIVAAAERALS-PKD-LAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNLP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 241 VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV 320
Cdd:PRK05579 242 TPAGVKRIDVESAQEMLDAVLAALPQADIFIMAAAVADYRPATVAEGKIKKGEGELTLELVPNPDILAEVAALKDKRPFV 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489821859 321 IGFAAETENLEANARKKLTSKNADMIVANNISvAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK 399
Cdd:PRK05579 322 VGFAAETGDVLEYARAKLKRKGLDLIVANDVS-AGGGFGSDDNEVTLIWSDGGEVKLPLMSKLELARRLLDEIAERLLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 1-392 2.73e-161

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 458.37  E-value: 2.73e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859    1 MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVaHIDLADWA 80
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   81 DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  161 RGRLEEPEKIVLRIAEFFQEDKDlLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFSPKED-LEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  241 VPPGVEAIYVESAEEMYQAVDEHKVS-QDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTaDQV 319
Cdd:TIGR00521 239 TPPGVKSIKVSTAEEMLEAALNELAKdFDIFISAAAVADFKPKTVFEGKIKKQGEELSLKLVKNPDIIAEVRKIKK-HQV 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821859  320 VIGFAAETEN-LEANARKKLTSKNADMIVANNISVaGAGFSGDTNIVTFYRKDGsSKALPILDKKEVAEHIIKE 392
Cdd:TIGR00521 318 IVGFKAETNDdLIKYAKEKLKKKNLDMIVANDVSQ-GRGFGSDENEVYIFSKHG-HKELPLMSKLEVAERILDE 389
PRK13982 PRK13982
bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; ...
 3-398 4.75e-122

bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional


Pssm-ID: 172484 [Multi-domain]  Cd Length: 475  Bit Score: 361.76  E-value: 4.75e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   3 GKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWADL 82
Cdd:PRK13982  70 SKRVTLIIGGGIAAYKALDLIRRLKERGAHVRCVLTKAAQQFVTPLTASALSGQRVYTDLFDPESEFDAGHIRLARDCDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  83 VIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLA-CGYVGR 161
Cdd:PRK13982 150 IVVAPATADLMAKMANGLADDLASAILLAANRPILLAPAMNPLMWNNPATRRNVAQLKRDGVHMIGPNAGEMAeRGEAGV 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 162 GRLEEPEKIVLRIAEFFQEDKD-LLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP 240
Cdd:PRK13982 230 GRMAEPLEIAAAAEALLRPPQPkPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGAEVTLISGPVDLA 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 241 VPPGVEAIYVESAEEMYQAVDEHkVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDF-AIEMKRTKDILLEIGqhKTADQ- 318
Cdd:PRK13982 310 DPQGVKVIHVESARQMLAAVEAA-LPADIAIFAAAVADWRVATEGGQKLKKGAAGPpPLQLVENPDILATIS--KLAENr 386

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 319 --VVIGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKAL---PILDKKEVAEHIIKET 393
Cdd:PRK13982 387 ppLVIGFAAETEHLIDNARAKLARKGCDWIVANDVSPATGVMGGDRNTVHLLSRDGDAEKVeswPVMTKDEVATALVARI 466


                 ....*
gi 489821859 394 ANFLR 398
Cdd:PRK13982 467 ASTFT 471
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 185-366 2.29e-97

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 288.15  E-value: 2.29e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  185 LRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALPVPPGVEAIYVESAEEMYQAVDEHK 264
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  265 VSQDIFVMTAAVADYTPAKVSDQKIKKQPGD--FAIEMKRTKDILLEIGQHKTaDQVVIGFAAETENLEANARKKLTSKN 342
Cdd:pfam04127  81 PEADIVIMAAAVADYRPAEVADGKIKKSSGGeeLTLELVKNPDILAELGKRKP-GQLLVGFAAETEDLLENARAKLERKN 159

                         170       180
                  ....*....|....*....|....
gi 489821859  343 ADMIVANNISVAGAGFSGDTNIVT 366
Cdd:pfam04127 160 LDLIVANDVSRPGAGFGSDTNEVT 183
PRK07313 PRK07313
phosphopantothenoylcysteine decarboxylase; Validated
 3-182 6.66e-80

phosphopantothenoylcysteine decarboxylase; Validated


Pssm-ID: 235986 [Multi-domain]  Cd Length: 182  Bit Score: 243.70  E-value: 6.66e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   3 GKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWADL 82
Cdd:PRK07313   1 MKNILLAVSGSIAAYKAADLTSQLTKRGYQVTVLMTKAATKFITPLTLQVLSKNPVHLDVMDEHDPKLMNHIELAKRADL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  83 VIVAPATANVIGKMANGIADDMVTTTILA--TEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG 160
Cdd:PRK07313  81 FLVAPATANTIAKLAHGIADDLVTSVALAlpATTPKLIAPAMNTKMYENPATQRNLKTLKEDGVQEIEPKEGLLACGDEG 160

                        170       180
                 ....*....|....*....|..
gi 489821859 161 RGRLEEPEKIVLRIAEFFQEDK 182
Cdd:PRK07313 161 YGALADIETILETIENTLKEKT 182
coaC_strep TIGR02113
phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single ...
 4-176 6.70e-59

phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single bifunctional protein catalyses phosphopantothenoylcysteine decarboxylase and phosphopantothenate--cysteine ligase activities, sequential steps in coenzyme A biosynthesis (see TIGR00521). These activities reside in separate proteins encoded by tandem genes in some bacterial lineages. This model describes proteins from the genera Streptococcus and Enterococcus homologous to the N-terminal region of TIGR00521, corresponding to phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 131168  Cd Length: 177  Bit Score: 189.64  E-value: 6.70e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859    4 KNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWADLV 83
Cdd:TIGR02113   1 KKILLAVTGSIAAYKAADLTSQLTKLGYDVTVLMTQAATQFITPLTLQVLSKNPVHLDVMDEHDPKVINHIELAKKADLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   84 IVAPATANVIGKMANGIADDMVTTTILA--TEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVGR 161
Cdd:TIGR02113  81 LVAPASANTIAHLAHGFADNIVTSVALAlpPETPKLIAPAMNTKMYQNPITQRNIKILKKIGYQEIQPKESLLACGDYGR 160

                         170
                  ....*....|....*
gi 489821859  162 GRLEEPEKIVLRIAE 176
Cdd:TIGR02113 161 GALADLDDILQTIKE 175
Flavoprotein pfam02441
Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes ...
 4-178 1.67e-43

Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).


Pssm-ID: 426775 [Multi-domain]  Cd Length: 177  Bit Score: 149.45  E-value: 1.67e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859    4 KNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVaHIDL---ADWA 80
Cdd:pfam02441   1 KRILVGITGSSAAIKALRLLEELKKEGAEVRVIMTKAAKKVITPETLAALSENVDEDLTWRELDDDIL-HIELasgARWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   81 DLVIVAPATANVIGKMANGIADDMVT----------------TTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGv 144
Cdd:pfam02441  80 DAMVIAPASANTLAKIANGIADNLLTraadvalkerrphlenMLTLTAKKPIIIAPAMNTAMYENPATLENLEDLKADG- 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 489821859  145 rfiepeegylacgyvGRGRLEEPEKIVLRIAEFF 178
Cdd:pfam02441 159 ---------------GKGRMPEPEAIVGKVLDAL 177
PLN02496 PLN02496
probable phosphopantothenoylcysteine decarboxylase
 6-179 1.90e-24

probable phosphopantothenoylcysteine decarboxylase


Pssm-ID: 215274  Cd Length: 209  Bit Score: 99.66  E-value: 1.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859   6 ILLAVSGGIAVYKAVALTSKLTQaGANVKVMMTEHAQEFVPPLSfqvLSKNDV-YTDTfDE-----KKSSVVAHIDLADW 79
Cdd:PLN02496  22 ILLAASGSVAAIKFGNLCHCFSE-WAEVRAVVTKASLHFIDRAS---LPKDVTlYTDE-DEwsswnKIGDSVLHIELRRW 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859  80 ADLVIVAPATANVIGKMANGIADDMVTTTILATE--APVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACG 157
Cdd:PLN02496  97 ADVMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDysKPLFVAPAMNTFMWNNPFTERHLMSIDELGISLIPPVTKRLACG 176

                        170       180
                 ....*....|....*....|..
gi 489821859 158 YVGRGRLEEPEKIVLRIAEFFQ 179
Cdd:PLN02496 177 DYGNGAMAEPSLIYSTVRLFLE 198
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 189-391 1.17e-23

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 98.14  E-value: 1.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 189 NVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKAL-PVP-PGVEAIYVESAEEMYQAVDEHKVS 266
Cdd:PRK06732   2 KILITSGGTTEPIDSVRGITNHSTGQLGKIIAETFLAAGHEVTLVTTKTAVkPEPhPNLSIIEIENVDDLLETLEPLVKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 267 QDIFVMTAAVADYTPAKVSD--------------------QKIKKQPGDFAIEMKRTKDILLEIGQhKTADQVVIGFA-- 324
Cdd:PRK06732  82 HDVLIHSMAVSDYTPVYMTDleevsasdnlnefltkqnteAKISSASDYQVLFLKKTPKVISYVKK-WNPNITLVGFKll 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489821859 325 --AETENLEANARKKLTSKNADMIVAN---NISVAG--AGFSGDTNIVTFYRKDGSSKALpildkkevAEHIIK 391
Cdd:PRK06732 161 vnVSKEELIKVARASLIKNQADYILANdltDISADQhkALLVSKNEVYTAQTKEEIADLL--------LERIEK 226
PRK09620 PRK09620
hypothetical protein; Provisional
 185-350 1.24e-11

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 63.76  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 185 LRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTL---------VTTSKALPVPPgVEAIyVESAEE 255
Cdd:PRK09620   1 MKGKKVLITSGGCLEKWDQVRGHTNMAKGTIGRIIAEELISKGAHVIYlhgyfaekpNDINNQLELHP-FEGI-IDLQDK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489821859 256 MYQAVDEHKVsqDIFVMTAAVADYTPAKVSDQKIK------KQPGDFA--IEMKRTKDILLEIGQHKtADQVVIGFAAET 327
Cdd:PRK09620  79 MKSIITHEKV--DAVIMAAAGSDWVVDKICDQEGNvldmngKISSDIApiIHFQKAPKVLKQIKQWD-PETVLVGFKLES 155

                        170       180
                 ....*....|....*....|....*..
gi 489821859 328 ENLE----ANARKKLTSKNADMIVANN 350
Cdd:PRK09620 156 DVNEeelfERAKNRMEEAKASVMIANS 182
AfpA COG1036
Archaeal flavoprotein [Energy production and conversion];
81-106 1.79e-05

Archaeal flavoprotein [Energy production and conversion];


Pssm-ID: 440659 [Multi-domain]  Cd Length: 174  Bit Score: 44.81  E-value: 1.79e-05
                         10        20
                 ....*....|....*....|....*.
gi 489821859  81 DLVIVAPATANVIGKMANGIADDMVT 106
Cdd:COG1036   81 DTLVIAPATSNTVAKIVLGIADTLVT 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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