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Conserved domains on  [gi|489822388|ref|WP_003726184|]
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tetratricopeptide repeat protein [Listeria monocytogenes]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708401)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_5 super family cl28784
Tetratrico peptide repeat; BH0479 of Bacillus halodurans is a hypothetical protein which ...
 35-150 1.22e-15

Tetratrico peptide repeat; BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions. This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the pfam00515, pfam07719, pfam07720 and pfam07221 models.


The actual alignment was detected with superfamily member pfam12688:

Pssm-ID: 403783 [Multi-domain]  Cd Length: 119  Bit Score: 68.71  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   35 AAWAHDALGKEDAAIPFYEKAIQLGLPVDSRKEAYIGLGSTYRITGQPEKASLLFQTALQEFPD--NNALRTFSVMAKYN 112
Cdd:pfam12688   7 RAGAFDSTGHPDRAVPLYRRALANGLDGSRRRQATIQLASSLRNLGEPEDALALLRAEATDPGDelDDALAAFLALCLAD 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489822388  113 QGLEKEALQEALILLTqttsdADILSYKKAIQFYAQDL 150
Cdd:pfam12688  87 LGREREAVSILLDALA-----PHLPRYQRSMTNYAREL 119
 
Name Accession Description Interval E-value
TPR_5 pfam12688
Tetratrico peptide repeat; BH0479 of Bacillus halodurans is a hypothetical protein which ...
 35-150 1.22e-15

Tetratrico peptide repeat; BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions. This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the pfam00515, pfam07719, pfam07720 and pfam07221 models.


Pssm-ID: 403783 [Multi-domain]  Cd Length: 119  Bit Score: 68.71  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   35 AAWAHDALGKEDAAIPFYEKAIQLGLPVDSRKEAYIGLGSTYRITGQPEKASLLFQTALQEFPD--NNALRTFSVMAKYN 112
Cdd:pfam12688   7 RAGAFDSTGHPDRAVPLYRRALANGLDGSRRRQATIQLASSLRNLGEPEDALALLRAEATDPGDelDDALAAFLALCLAD 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489822388  113 QGLEKEALQEALILLTqttsdADILSYKKAIQFYAQDL 150
Cdd:pfam12688  87 LGREREAVSILLDALA-----PHLPRYQRSMTNYAREL 119
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 4-155 9.18e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 9.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   4 TLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLgLPVDSrkEAYIGLGSTYRITGQPE 83
Cdd:COG3914  121 LLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALEL-DPDNA--EALNNLGNALQDLGRLE 197

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489822388  84 KASLLFQTALQEFPDNNALRTFSVMAKYNQGL--EKEALQEALILLTQTTSDADILsykkaIQFYAQDLDATFH 155
Cdd:COG3914  198 EAIAAYRRALELDPDNADAHSNLLFALRQACDweVYDRFEELLAALARGPSELSPF-----ALLYLPDDDPAEL 266
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1-151 4.43e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 36.60  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388    1 MILTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlPVDSrkEAYIGLGSTYRITG 80
Cdd:TIGR02917 335 LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELD-PENA--AARTQLGISKLSQG 411

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489822388   81 QPEKASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQFYAQDLD 151
Cdd:TIGR02917 412 DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLA 482
 
Name Accession Description Interval E-value
TPR_5 pfam12688
Tetratrico peptide repeat; BH0479 of Bacillus halodurans is a hypothetical protein which ...
 35-150 1.22e-15

Tetratrico peptide repeat; BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions. This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the pfam00515, pfam07719, pfam07720 and pfam07221 models.


Pssm-ID: 403783 [Multi-domain]  Cd Length: 119  Bit Score: 68.71  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   35 AAWAHDALGKEDAAIPFYEKAIQLGLPVDSRKEAYIGLGSTYRITGQPEKASLLFQTALQEFPD--NNALRTFSVMAKYN 112
Cdd:pfam12688   7 RAGAFDSTGHPDRAVPLYRRALANGLDGSRRRQATIQLASSLRNLGEPEDALALLRAEATDPGDelDDALAAFLALCLAD 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489822388  113 QGLEKEALQEALILLTqttsdADILSYKKAIQFYAQDL 150
Cdd:pfam12688  87 LGREREAVSILLDALA-----PHLPRYQRSMTNYAREL 119
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 4-155 9.18e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 9.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   4 TLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLgLPVDSrkEAYIGLGSTYRITGQPE 83
Cdd:COG3914  121 LLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALEL-DPDNA--EALNNLGNALQDLGRLE 197

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489822388  84 KASLLFQTALQEFPDNNALRTFSVMAKYNQGL--EKEALQEALILLTQTTSDADILsykkaIQFYAQDLDATFH 155
Cdd:COG3914  198 EAIAAYRRALELDPDNADAHSNLLFALRQACDweVYDRFEELLAALARGPSELSPF-----ALLYLPDDDPAEL 266
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-139 1.90e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 57.70  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   2 ILTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRITGQ 81
Cdd:COG3914   85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALN---PDFAEAYLNLGEALRRLGR 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489822388  82 PEKASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSY 139
Cdd:COG3914  162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 14-144 1.33e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388  14 ARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLglpVDSRKEAYIGLGSTYRITGQPEKASLLFQTAL 93
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL---DPDNADALLDLAEALLAAGDTEEAEELLERAL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489822388  94 QEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQ 144
Cdd:COG4235   79 ALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIA 129
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-151 2.01e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   3 LTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGLpvdSRKEAYIGLGSTYRITGQP 82
Cdd:COG0457   16 LAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDP---DDAEALNNLGLALQALGRY 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489822388  83 EKASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQFYAQDLD 151
Cdd:COG0457   93 EEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 3-152 4.09e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   3 LTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRITGQP 82
Cdd:COG2956   16 LNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERD---PDRAEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388  83 EKASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQFYAQDLDA 152
Cdd:COG2956   93 DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-152 1.50e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   3 LTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRITGQP 82
Cdd:COG0457   50 LAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD---PDDAEALYNLGLALLELGRY 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388  83 EKASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQFYAQDLDA 152
Cdd:COG0457  127 DEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVL 196
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 4-99 1.92e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   4 TLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlPVDSrkEAYIGLGSTYRITGQPE 83
Cdd:COG4783   47 ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD-PEHP--EAYLRLARAYRALGRPD 123

                         90
                 ....*....|....*.
gi 489822388  84 KASLLFQTALQEFPDN 99
Cdd:COG4783  124 EAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 5-127 2.46e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   5 LLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRITGQPEK 84
Cdd:COG4783   14 LLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD---PDEPEARLNLGLALLKAGDYDE 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489822388  85 ASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILL 127
Cdd:COG4783   91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 5-144 3.10e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   5 LLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLgLPVDSRkeAYIGLGSTYRITGQPEK 84
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL-DPDCAR--ALLLLAELYLEQGDYEE 196

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388  85 ASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQ 144
Cdd:COG2956  197 AIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLE 256
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 5-101 5.94e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.37  E-value: 5.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   5 LLQNGDYETART---QALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGLPVDSRKEAYIGLGSTYRITGQ 81
Cdd:COG1729    3 LLKAGDYDEAIAafkAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLELGD 82

                         90       100
                 ....*....|....*....|
gi 489822388  82 PEKASLLFQTALQEFPDNNA 101
Cdd:COG1729   83 YDKARATLEELIKKYPDSEA 102
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
5-98 7.02e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.08  E-value: 7.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   5 LLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFyEKAIQLGlpvDSRKEAYIGLGSTYRITGQPEK 84
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLD---PNNAEALLNLAELLLELGDYDE 77

                         90
                 ....*....|....
gi 489822388  85 ASLLFQTALQEFPD 98
Cdd:COG3063   78 ALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 26-152 3.30e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 3.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388  26 SDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLglpVDSRKEAYIGLGSTYRITGQPEKASLLFQTALQEFPDNNALRTF 105
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALEL---DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLN 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489822388 106 SVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQFYAQDLDA 152
Cdd:COG4783   78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
3-99 4.58e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.82  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   3 LTLLQNGDYETAR---TQALAElknNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRIT 79
Cdd:COG4785   81 VAYDSLGDYDLAIadfDQALEL---DPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD---PDYAYAYLNRGIALYYL 154

                         90       100
                 ....*....|....*....|
gi 489822388  80 GQPEKASLLFQTALQEFPDN 99
Cdd:COG4785  155 GRYELAIADLEKALELDPND 174
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 3-94 1.11e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.05  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   3 LTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLglpvDSRKEAYIGLGSTYRITGQP 82
Cdd:COG3071  232 YGRLQGGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALAL----RPSAEAYAELARLLEQLGDP 307

                         90
                 ....*....|..
gi 489822388  83 EKASLLFQTALQ 94
Cdd:COG3071  308 EEAAEHYRKALA 319
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
22-121 1.40e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388  22 LKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRITGQPEKASLLFQTALQEFPDNNA 101
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELD---PDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAE 77

                         90       100
                 ....*....|....*....|
gi 489822388 102 LRTFSVMAKYNQGLEKEALQ 121
Cdd:COG0457   78 ALNNLGLALQALGRYEEALE 97
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-97 4.46e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   2 ILTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlpvDSRKEAYIGLGSTYRITGQ 81
Cdd:COG5010   61 DNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS---PDNPNAYSNLAALLLSLGQ 137

                         90
                 ....*....|....*.
gi 489822388  82 PEKASLLFQTALQEFP 97
Cdd:COG5010  138 DDEAKAALQRALGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1-151 4.43e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 36.60  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388    1 MILTLLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLGlPVDSrkEAYIGLGSTYRITG 80
Cdd:TIGR02917 335 LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELD-PENA--AARTQLGISKLSQG 411

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489822388   81 QPEKASLLFQTALQEFPDNNALRTFSVMAKYNQGLEKEALQEALILLTQTTSDADILSYKKAIQFYAQDLD 151
Cdd:TIGR02917 412 DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLA 482
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 5-95 9.32e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 35.09  E-value: 9.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489822388   5 LLQNGDYETARTQALAELKNNSDNAELHYYAAWAHDALGKEDAAIPFYEKAIQLglpvDSRKEAYIGLGSTYRITGQPEK 84
Cdd:COG2956  188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL----DPSDDLLLALADLLERKEGLEA 263

                         90
                 ....*....|.
gi 489822388  85 ASLLFQTALQE 95
Cdd:COG2956  264 ALALLERQLRR 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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