resuscitation-promoting factor [Listeria monocytogenes]
Protein Classification
G5 and 3D domain-containing protein( domain architecture ID 13401414)
G5 and 3D (Asp-Asp-Asp) domain-containing protein contains a G5 domain with similarity to resuscitation-promoting factor, a cell-wall glycosidase that cleaves cell-wall peptidoglycan, and a C-terminal 3D domain that contains the critical active site aspartate of MltA-like lytic transglycosylases; also contains DUF348 domains
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| YabE | COG3583 | Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function ... |
12-396 | 2.13e-66 | ||||||
Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown]; : Pssm-ID: 442802 [Multi-domain] Cd Length: 335 Bit Score: 214.35 E-value: 2.13e-66
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| DUF348 | pfam03990 | G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is ... |
100-140 | 5.79e-09 | ||||||
G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593. This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis. The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the pfam07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5. : Pssm-ID: 461121 [Multi-domain] Cd Length: 41 Bit Score: 51.26 E-value: 5.79e-09
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| Name | Accession | Description | Interval | E-value | ||||||
| YabE | COG3583 | Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function ... |
12-396 | 2.13e-66 | ||||||
Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown]; Pssm-ID: 442802 [Multi-domain] Cd Length: 335 Bit Score: 214.35 E-value: 2.13e-66
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| DPBB_YuiC-like | cd22786 | double-psi beta-barrel fold of YuiC subfamily proteins; The YuiC subfamily includes a group of ... |
314-404 | 9.49e-33 | ||||||
double-psi beta-barrel fold of YuiC subfamily proteins; The YuiC subfamily includes a group of conserved double-psi beta-barrel (DPBB) fold proteins, such as Bacillus subtilis protein YuiC, cell wall shaping protein YabE, cell wall-binding protein YocH, as well as Clostridium tetani phosphatase-associated protein PapQ. YuiC is a Firmicute stationary phase survival (Sps) protein that closely resembles the Barwin-like endoglucanase beta barrel of MltA. It is a double-psi beta-barrel (DPBB) fold that consists of two interlocked "psi-structure" motifs related by a pseudo-2-fold axis and may be involved in substrate binding and catalysis. Pssm-ID: 439263 [Multi-domain] Cd Length: 96 Bit Score: 118.47 E-value: 9.49e-33
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| wall_bind_EntD | NF040675 | cell wall-binding protein EntD; This HMM describes the cell wall-binding protein EntD, as ... |
270-403 | 1.36e-30 | ||||||
cell wall-binding protein EntD; This HMM describes the cell wall-binding protein EntD, as found in Bacillus cereus. EntD, like its close homolog EntA, is related to EntB and EntC, but lacks the central region of KAXEXX repeats that EntB and EndC share. Ent proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. They may play a role in maintenance of cell wall structure and stress responses that support virulence, and probably lack any direct role as enterotoxins. Pssm-ID: 468641 [Multi-domain] Cd Length: 310 Bit Score: 119.42 E-value: 1.36e-30
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| wall_bind_EntC | NF040677 | cell wall-binding protein EntC; This HMM describes the cell wall-binding protein EntC, as ... |
330-404 | 3.55e-29 | ||||||
cell wall-binding protein EntC; This HMM describes the cell wall-binding protein EntC, as found in Bacillus cereus. EntC is related to EntA, EntB, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity. Pssm-ID: 468643 [Multi-domain] Cd Length: 422 Bit Score: 117.61 E-value: 3.55e-29
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| wall_bind_EntA | NF040670 | cell wall-binding protein EntA; This HMM describes the cell wall-binding protein EntA, as ... |
324-403 | 1.11e-27 | ||||||
cell wall-binding protein EntA; This HMM describes the cell wall-binding protein EntA, as found in Bacillus cereus. EntA is related to EntB, EntC, and EndD, but it lacks the central region of KAXEXX repeats that EntB and EndC have. EntD also lacks those repeats. Ent proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. Pssm-ID: 468636 [Multi-domain] Cd Length: 291 Bit Score: 110.98 E-value: 1.11e-27
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| wall_bind_EntB | NF040676 | cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ... |
320-403 | 2.50e-27 | ||||||
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity. Pssm-ID: 468642 [Multi-domain] Cd Length: 476 Bit Score: 112.95 E-value: 2.50e-27
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| 3D | pfam06725 | 3D domain; This short presumed domain contains three conserved aspartate residues, hence the ... |
343-404 | 2.20e-20 | ||||||
3D domain; This short presumed domain contains three conserved aspartate residues, hence the name 3D. It has been shown to be part of the catalytic double psi beta barrel domain of MltA. Pssm-ID: 399598 [Multi-domain] Cd Length: 72 Bit Score: 84.18 E-value: 2.20e-20
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| DUF348 | pfam03990 | G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is ... |
100-140 | 5.79e-09 | ||||||
G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593. This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis. The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the pfam07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5. Pssm-ID: 461121 [Multi-domain] Cd Length: 41 Bit Score: 51.26 E-value: 5.79e-09
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| PspC_relate_1 | NF033840 | PspC-related protein choline-binding protein 1; Members of this family share C-terminal ... |
202-295 | 4.27e-03 | ||||||
PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC. Pssm-ID: 411409 [Multi-domain] Cd Length: 648 Bit Score: 39.29 E-value: 4.27e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| YabE | COG3583 | Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function ... |
12-396 | 2.13e-66 | ||||||
Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown]; Pssm-ID: 442802 [Multi-domain] Cd Length: 335 Bit Score: 214.35 E-value: 2.13e-66
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| COG3584 | COG3584 | 3D (Asp-Asp-Asp) domain, usually in lytic transglycosylases [Function unknown]; 3D ... |
318-404 | 1.73e-39 | ||||||
3D (Asp-Asp-Asp) domain, usually in lytic transglycosylases [Function unknown]; 3D (Asp-Asp-Asp) domain, usually in lytic transglycosylases is part of the Pathway/BioSystem: 3D Pssm-ID: 442803 [Multi-domain] Cd Length: 92 Bit Score: 136.01 E-value: 1.73e-39
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| DPBB_YuiC-like | cd22786 | double-psi beta-barrel fold of YuiC subfamily proteins; The YuiC subfamily includes a group of ... |
314-404 | 9.49e-33 | ||||||
double-psi beta-barrel fold of YuiC subfamily proteins; The YuiC subfamily includes a group of conserved double-psi beta-barrel (DPBB) fold proteins, such as Bacillus subtilis protein YuiC, cell wall shaping protein YabE, cell wall-binding protein YocH, as well as Clostridium tetani phosphatase-associated protein PapQ. YuiC is a Firmicute stationary phase survival (Sps) protein that closely resembles the Barwin-like endoglucanase beta barrel of MltA. It is a double-psi beta-barrel (DPBB) fold that consists of two interlocked "psi-structure" motifs related by a pseudo-2-fold axis and may be involved in substrate binding and catalysis. Pssm-ID: 439263 [Multi-domain] Cd Length: 96 Bit Score: 118.47 E-value: 9.49e-33
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| wall_bind_EntD | NF040675 | cell wall-binding protein EntD; This HMM describes the cell wall-binding protein EntD, as ... |
270-403 | 1.36e-30 | ||||||
cell wall-binding protein EntD; This HMM describes the cell wall-binding protein EntD, as found in Bacillus cereus. EntD, like its close homolog EntA, is related to EntB and EntC, but lacks the central region of KAXEXX repeats that EntB and EndC share. Ent proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. They may play a role in maintenance of cell wall structure and stress responses that support virulence, and probably lack any direct role as enterotoxins. Pssm-ID: 468641 [Multi-domain] Cd Length: 310 Bit Score: 119.42 E-value: 1.36e-30
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| 3D_containing_proteins | cd14667 | Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues; ... |
319-403 | 4.29e-30 | ||||||
Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues; This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond. Pssm-ID: 270620 [Multi-domain] Cd Length: 90 Bit Score: 111.08 E-value: 4.29e-30
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| wall_bind_EntC | NF040677 | cell wall-binding protein EntC; This HMM describes the cell wall-binding protein EntC, as ... |
330-404 | 3.55e-29 | ||||||
cell wall-binding protein EntC; This HMM describes the cell wall-binding protein EntC, as found in Bacillus cereus. EntC is related to EntA, EntB, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity. Pssm-ID: 468643 [Multi-domain] Cd Length: 422 Bit Score: 117.61 E-value: 3.55e-29
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| wall_bind_EntA | NF040670 | cell wall-binding protein EntA; This HMM describes the cell wall-binding protein EntA, as ... |
324-403 | 1.11e-27 | ||||||
cell wall-binding protein EntA; This HMM describes the cell wall-binding protein EntA, as found in Bacillus cereus. EntA is related to EntB, EntC, and EndD, but it lacks the central region of KAXEXX repeats that EntB and EndC have. EntD also lacks those repeats. Ent proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. Pssm-ID: 468636 [Multi-domain] Cd Length: 291 Bit Score: 110.98 E-value: 1.11e-27
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| wall_bind_EntB | NF040676 | cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ... |
320-403 | 2.50e-27 | ||||||
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity. Pssm-ID: 468642 [Multi-domain] Cd Length: 476 Bit Score: 112.95 E-value: 2.50e-27
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| 3D | pfam06725 | 3D domain; This short presumed domain contains three conserved aspartate residues, hence the ... |
343-404 | 2.20e-20 | ||||||
3D domain; This short presumed domain contains three conserved aspartate residues, hence the name 3D. It has been shown to be part of the catalytic double psi beta barrel domain of MltA. Pssm-ID: 399598 [Multi-domain] Cd Length: 72 Bit Score: 84.18 E-value: 2.20e-20
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| G5 | pfam07501 | G5 domain; This domain is found in a wide range of extracellular proteins. It is found ... |
216-287 | 4.82e-20 | ||||||
G5 domain; This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies. It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA. The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function. Pssm-ID: 462185 [Multi-domain] Cd Length: 75 Bit Score: 83.37 E-value: 4.82e-20
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| DPBB_MltA_YuiC-like | cd22784 | double-psi beta-barrel fold of membrane-bound lytic murein transglycosylase A (MltA) and ... |
322-402 | 1.63e-19 | ||||||
double-psi beta-barrel fold of membrane-bound lytic murein transglycosylase A (MltA) and YuiC-like proteins; This family includes two subfamilies of conserved double-psi beta-barrel (DPBB) domain proteins, such as membrane-bound lytic murein transglycosylase A (MltA)-like proteins and YuiC-like proteins. MltA, also called murein hydrolase A, is a murein-degrading enzyme that may play a role in the recycling of muropeptides during cell elongation and/or cell division. It degrades murein glycan strands and insoluble, high-molecular weight murein sacculi. Bacterial lytic transglycosylases (LTs) are classified into 4 families: family 1 includes slt70 MltC-MltF, family 2 includes MltA, family 3 includes MltB, and family 4 includes proteins of bacteriophage origin. MltA is distinct from other bacterial LTs, which are similar in structure and sequence with a lysozyme-like fold. MltA is a kidney bean-shaped monomeric protein comprised of two domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, which corresponds to a double-psi beta-barrel (DPBB) fold. Domain B also has a beta-barrel fold topology, but it is inserted within the linear sequence of domain A. YuiC is a Firmicute stationary phase survival (Sps) protein that closely resembles the Barwin-like endoglucanase beta barrel of MltA. It is a DPBB fold that consists of two interlocked "psi-structure" motifs related by a pseudo-2-fold axis and may be involved in substrate binding and catalysis. Pssm-ID: 439261 [Multi-domain] Cd Length: 92 Bit Score: 82.69 E-value: 1.63e-19
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| 3D_domain | cd14486 | 3D domain, named for 3 conserved aspartate residues, is found in mltA-like lytic ... |
313-403 | 1.69e-16 | ||||||
3D domain, named for 3 conserved aspartate residues, is found in mltA-like lytic transglycosylases and numerous other contexts; This family contains the 3D domain, named for its 3 conserved aspartates. It is found in conjunction with numerous other domains such as MltA (membrane-bound lytic murein transglycosylase A). These aspartates are critical active site residues of mltA-like lytic transglycosylases. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. MltA has 2 domains, separated by a large groove, where the peptidoglycan strand binds. The C-terminus has a double-psi beta barrel fold within the 3D domain, which forms the larger A domain along with the N-terminal region of Mlts, but is also found in various other domain architectures. Peptigoglycan (also known as murein) chains, the primary structural component of bacterial cells walls, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc); lytic transglycosylases (LTs) cleave this beta-1-4 bond. Typically, LTs are exolytic, releasing Metabolite 1 (GlcNAc-anhMurNAc-L-Ala-D-Glu-m-Dap-D-Ala-D-Ala) from the ends of the PG strands. In contrast, membrane-bound lytic murein transglycosylase E (MltE) is endolytic , cleaving in the middle of PG strands, with further processing to Metabolite 1 accomplished by other LTs. In E. coli, there are six membrane- bound LTs: MltA-MltF and soluble Slt70. Slt35 is a soluble fragment cleaved from MltB. Bacterial LTs are classified in 4 families: Family 1 includes slt70 MltC-MltF, Family 2 includes MltA, Family 3 includes MltB, and family 4 of bacteriophage origin. While most LTs are related members of the lysozyme-like lytic transglycosylase family, MltA represents a distinct fold and sequence conservation. Pssm-ID: 270619 [Multi-domain] Cd Length: 104 Bit Score: 74.72 E-value: 1.69e-16
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| DPBB_MltA-like | cd22785 | double-psi beta-barrel fold of membrane-bound lytic murein transglycosylase A (MltA) and ... |
345-383 | 1.82e-10 | ||||||
double-psi beta-barrel fold of membrane-bound lytic murein transglycosylase A (MltA) and similar proteins; MltA, also called murein hydrolase A, is a murein-degrading enzyme that may play a role in the recycling of muropeptides during cell elongation and/or cell division. It degrades murein glycan strands and insoluble, high-molecular weight murein sacculi. Bacterial lytic transglycosylases (LTs) are classified into 4 families: family 1 includes slt70 MltC-MltF, family 2 includes MltA, family 3 includes MltB, and family 4 includes proteins of bacteriophage origin. MltA is distinct from other bacterial LTs, which are similar in structure and sequence with a lysozyme-like fold. MltA is a kidney bean-shaped monomeric protein comprised of two domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, which corresponds to a double-psi beta-barrel (DPBB) fold. Domain B also has a beta-barrel fold topology, but it is inserted within the linear sequence of domain A. This model corresponds to the DPBB fold that consists of two interlocked "psi-structure" motifs related by a pseudo-2-fold axis. It is involved in substrate binding and catalysis. Pssm-ID: 439262 [Multi-domain] Cd Length: 97 Bit Score: 57.27 E-value: 1.82e-10
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| DUF348 | pfam03990 | G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is ... |
100-140 | 5.79e-09 | ||||||
G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593. This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis. The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the pfam07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5. Pssm-ID: 461121 [Multi-domain] Cd Length: 41 Bit Score: 51.26 E-value: 5.79e-09
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| mltA_like_LT_A | cd14485 | Domain A of MltA and related lytic transglycosylase; domain A is interrupted by domain B; ... |
345-384 | 1.88e-07 | ||||||
Domain A of MltA and related lytic transglycosylase; domain A is interrupted by domain B; Escherichia coli MltA is a membrane-bound lytic transglycosylase comprised of two domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, which correspond to the 3D domain, named for 3 conserved aspartate residues. Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial lytic transglycosylases (LTs), which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond. Typically, peptidoglycan lytic transglycosylases (LT) are exolytic, releasing Metabolite 1 (GlcNAc-anhMurNAc-L-Ala-D-Glu-m-Dap-D-Ala-D-Ala) from the ends of the PG strands. In contrast, MltE is endolytic , cleaving in the middle of PG strands, with further processing to Metabolite 1 accomplished by other LTs. In E. coli, there are six membrane-bound LTs: MltA-MltF and soluble Slt70. Slt35 is a soluble fragment cleaved from MltB. Bacterial LTs are classified in 4 families: Family 1 includes slt70 MltC-MltF, Family 2 includes MltA, Family 3 includes MltB, and Family 4 of bacteriophage origin. While most of the LT family members are similar in structure and sequence with a lysozyme-like fold, Family 2 (including mltA) is distinct. Pssm-ID: 270618 [Multi-domain] Cd Length: 159 Bit Score: 50.32 E-value: 1.88e-07
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| DUF348 | pfam03990 | G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is ... |
43-83 | 4.76e-07 | ||||||
G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593. This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis. The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the pfam07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5. Pssm-ID: 461121 [Multi-domain] Cd Length: 41 Bit Score: 45.87 E-value: 4.76e-07
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| DUF348 | pfam03990 | G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is ... |
161-197 | 9.45e-07 | ||||||
G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593. This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis. The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the pfam07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5. Pssm-ID: 461121 [Multi-domain] Cd Length: 41 Bit Score: 45.10 E-value: 9.45e-07
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| MltA | COG2821 | Membrane-bound lytic murein transglycosylase [Cell wall/membrane/envelope biogenesis]; |
345-384 | 3.93e-06 | ||||||
Membrane-bound lytic murein transglycosylase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442069 [Multi-domain] Cd Length: 388 Bit Score: 48.72 E-value: 3.93e-06
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| YoaR | COG2720 | Vancomycin resistance protein YoaR (function unknown), contains peptidoglycan-binding and VanW ... |
201-270 | 7.58e-05 | ||||||
Vancomycin resistance protein YoaR (function unknown), contains peptidoglycan-binding and VanW domains [Defense mechanisms]; Pssm-ID: 442033 [Multi-domain] Cd Length: 449 Bit Score: 44.81 E-value: 7.58e-05
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| PspC_relate_1 | NF033840 | PspC-related protein choline-binding protein 1; Members of this family share C-terminal ... |
202-295 | 4.27e-03 | ||||||
PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC. Pssm-ID: 411409 [Multi-domain] Cd Length: 648 Bit Score: 39.29 E-value: 4.27e-03
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