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Conserved domains on  [gi|489826277|ref|WP_003730049|]
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carbohydrate ABC transporter permease [Listeria monocytogenes]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
2-294 5.10e-117

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 338.26  E-value: 5.10e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   2 ATIRNKSVQIHQQRMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDIVN-SPNWIGFDNYIKMFRDPYFLISLKNTIIY 80
Cdd:COG1175    5 TSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGpPPEFVGLDNYARLFTDPRFWNALGNTLLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  81 TALFVPLGLVASLGAAILINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLINRVLGWFGINGPAWLYDSNWA 160
Cdd:COG1175   85 TVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 161 MFAIVMMSVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTMLIINAFQVFDQAYVLT 240
Cdd:COG1175  165 LPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLT 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489826277 241 KGGPGNSTITLVYYIYNEGFGGLKMGYASAISFVLFLIILVFSIINMRVNKEDR 294
Cdd:COG1175  245 GGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
2-294 5.10e-117

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 338.26  E-value: 5.10e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   2 ATIRNKSVQIHQQRMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDIVN-SPNWIGFDNYIKMFRDPYFLISLKNTIIY 80
Cdd:COG1175    5 TSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGpPPEFVGLDNYARLFTDPRFWNALGNTLLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  81 TALFVPLGLVASLGAAILINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLINRVLGWFGINGPAWLYDSNWA 160
Cdd:COG1175   85 TVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 161 MFAIVMMSVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTMLIINAFQVFDQAYVLT 240
Cdd:COG1175  165 LPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLT 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489826277 241 KGGPGNSTITLVYYIYNEGFGGLKMGYASAISFVLFLIILVFSIINMRVNKEDR 294
Cdd:COG1175  245 GGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
19-288 2.53e-41

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 144.20  E-value: 2.53e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  19 LFIALPVLLLAIFMILPIGMALFVSFTDYDIVN-SPNWIGFDNYIKMFRDPYFLISLKNTIIYTALFVPLGLVASLGAAI 97
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGfSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  98 LINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLINRVLGWFGINgpaWLY--DSNWAMFAIVMMSVWMTFGT 175
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYD---WNHaqNSGQAMFLVVFASVWKQISY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 176 NMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTT-FLVTTMLIINAFQVFDQAYVLTKGGPGNSTITLVYY 254
Cdd:PRK10561 158 NFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSfFLLVVNLVYAFFDTFPVIDAATSGGPVQATTTLIYK 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489826277 255 IYNEGFGGLKMGYASAISFVLFLIILVFSIINMR 288
Cdd:PRK10561 238 IYREGFTGLDLSSSAAQSVVLMFLVIVLTVVQFR 271
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 15-226 2.31e-19

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 87.81  E-value: 2.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   15 RMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDivnsPNWIGFDNYIKMFRDPYFLISLKNTI----IYTALFVPLglv 90
Cdd:TIGR03262   1 LIARLLLAGMILALLLFLLLPLLALLTKSVYDSD----GDFIGLANFAEYFATPGLLQSLGNSLtvsaIVTAIVVPL--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   91 ASLGAAILINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQyGLINRVLGWFGINGPawlydsnwamFAIVMMSVW 170
Cdd:TIGR03262  74 AFAFAYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQ-GLLKGLLGGFSIYGF----------WGIVIGEVF 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  171 MTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPS----LSRTTFLVTTMLI 226
Cdd:TIGR03262 143 YTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGakygLISAAFVVFTLVI 202
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-280 1.52e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 59.21  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  74 LKNTIIYTALFVPLGLVASLGAAILINMN-KKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGlinrvlgwfgingpa 152
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 153 WLYDSNWAMFAIVMMSVWMtFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTMLIINAFQV 232
Cdd:cd06261   66 WGILPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGE 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489826277 233 FDQAYVLtkGGPGNSTITLVYYIYNEGFGGLKMGYASAISFVLFLIIL 280
Cdd:cd06261  145 FALVSFL--GGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 145-285 4.58e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.00  E-value: 4.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  145 WFGINGPAWLYDSNWAMFAIVMMSVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTM 224
Cdd:pfam00528  36 AILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLAL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489826277  225 LIINAFQVFDQAYVLTKGGPGNSTITLVYYIYNEGFGglkMGYASAISFVLFLIILVFSII 285
Cdd:pfam00528 116 AFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEI---QGPVLAAALILLLLNLLVDIL 173
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
2-294 5.10e-117

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 338.26  E-value: 5.10e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   2 ATIRNKSVQIHQQRMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDIVN-SPNWIGFDNYIKMFRDPYFLISLKNTIIY 80
Cdd:COG1175    5 TSAAARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGpPPEFVGLDNYARLFTDPRFWNALGNTLLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  81 TALFVPLGLVASLGAAILINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLINRVLGWFGINGPAWLYDSNWA 160
Cdd:COG1175   85 TVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPINWLGDPSLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 161 MFAIVMMSVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTMLIINAFQVFDQAYVLT 240
Cdd:COG1175  165 LPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLT 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489826277 241 KGGPGNSTITLVYYIYNEGFGGLKMGYASAISFVLFLIILVFSIINMRVNKEDR 294
Cdd:COG1175  245 GGGPGNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 5-281 2.33e-49

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 166.03  E-value: 2.33e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   5 RNKSVQIHQQRMAYLFIALPVLLLAIFMILPIGmALFVSFTDYD----IVNSPnWIGFDNYIKMFRDPYFLISLKNTIIY 80
Cdd:COG4209   17 KSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPMY-GIVIAFKDYNpfkgIFGSP-WVGLKNFKFLFSSPDFWRVLRNTLLI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  81 TALFVPLGLVASLGAAILIN--MNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLINRVLGWFGINGPAWLYDSN 158
Cdd:COG4209   95 SLLKLVFGFPLPIILALLLNelRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGGEPINFLTEPK 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 159 WAMFAIVMMSVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTtflVTTMLIINAFQV----FD 234
Cdd:COG4209  175 YFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPT---IVILLILNIGNIlnvgFE 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489826277 235 QAYVLTKGGPGNSTITLVYYIYNEGFGGLKMGYASAISFV-----LFLIILV 281
Cdd:COG4209  252 QIYLLYNPLNYSTSDVIDTYVYRIGLQNGDYSYATAVGLFksvvgLILVLIA 303
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
19-288 2.53e-41

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 144.20  E-value: 2.53e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  19 LFIALPVLLLAIFMILPIGMALFVSFTDYDIVN-SPNWIGFDNYIKMFRDPYFLISLKNTIIYTALFVPLGLVASLGAAI 97
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGfSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  98 LINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLINRVLGWFGINgpaWLY--DSNWAMFAIVMMSVWMTFGT 175
Cdd:PRK10561  81 LVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYD---WNHaqNSGQAMFLVVFASVWKQISY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 176 NMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTT-FLVTTMLIINAFQVFDQAYVLTKGGPGNSTITLVYY 254
Cdd:PRK10561 158 NFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSfFLLVVNLVYAFFDTFPVIDAATSGGPVQATTTLIYK 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489826277 255 IYNEGFGGLKMGYASAISFVLFLIILVFSIINMR 288
Cdd:PRK10561 238 IYREGFTGLDLSSSAAQSVVLMFLVIVLTVVQFR 271
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 8-294 1.94e-32

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 121.02  E-value: 1.94e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   8 SVQIHQQRMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDIVNSPNW-IGFDNYIKMFRDPYFLISLKNTIIYTALFVP 86
Cdd:COG1176    2 SAALRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPgFTLENYARLFTDPLYLKVLLRTLWIALLTTL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  87 LGLVASLGAAILI-NMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQyGLINRVLGWFG-INGPAWLYDSNWAMFaI 164
Cdd:COG1176   82 ICLLLGYPIAYFLaRAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRN-GLLNSLLLALGlIDEPLRLLYTEFAVV-I 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 165 VMMSVWMTFgtnmMIF--LAGLQGIPANLYEASKIEGASRWKTFRYVTWPsLSRTTFLVTTMLI-INAFQVFDQAYVLtk 241
Cdd:COG1176  160 GLVYVYLPF----MVLplYAALEKIDPSLLEAARDLGASPWQTFRRVILP-LSLPGIIAGSLLVfIPALGAFVTPALL-- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489826277 242 GGPGNSTITLVyyIYNEGFGGLKMGYASAISFVLFLIILVFSIINMRVNKEDR 294
Cdd:COG1176  233 GGGKVLMIGNL--IYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRRR 283
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
15-289 6.34e-23

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 98.31  E-value: 6.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  15 RMAYLFIALPVLLLAIFMILPIGMALFVSFTDydivnspnwiGFDNYIKMFRDPYFLISLKNTIIYTALFVPLGLVASLG 94
Cdd:COG1178    7 RRPRLLLLLLALLLALLVLLPLLALLLRAFTD----------GLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  95 AAILINM-NKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQyGLINRVLG-WFGINGPawlydSNWAMFAIVMMSVWMT 172
Cdd:COG1178   77 LAWLLARtDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPN-GLLNTLLRaLFGLEPP-----DIYGLGGIILVLVLFN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 173 FGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRT---TFLVTTMLIINAFQVfdqAYVLtkgGPGNSTI 249
Cdd:COG1178  151 YPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAiaaGALLVFLLCLADFGT---PLVL---GGGYTTL 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 489826277 250 TLvyYIYNEGFGGLKMGYASAISFVLFLIILVFSIINMRV 289
Cdd:COG1178  225 TT--AIYQAWLGDFDLGAAAALALVLLLLVLLLLLLERRL 262
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 15-226 2.31e-19

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 87.81  E-value: 2.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   15 RMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDivnsPNWIGFDNYIKMFRDPYFLISLKNTI----IYTALFVPLglv 90
Cdd:TIGR03262   1 LIARLLLAGMILALLLFLLLPLLALLTKSVYDSD----GDFIGLANFAEYFATPGLLQSLGNSLtvsaIVTAIVVPL--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277   91 ASLGAAILINMNKKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQyGLINRVLGWFGINGPawlydsnwamFAIVMMSVW 170
Cdd:TIGR03262  74 AFAFAYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQ-GLLKGLLGGFSIYGF----------WGIVIGEVF 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  171 MTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPS----LSRTTFLVTTMLI 226
Cdd:TIGR03262 143 YTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGakygLISAAFVVFTLVI 202
malF PRK10999
maltose ABC transporter permease MalF;
55-291 1.12e-18

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 85.78  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  55 WIGFDNYIKMFRD-----PYFLISLKnTIIYTALFVPLGLVASLGAAILINMNK-KGAGLFRTFFYVPVLCSTVATATIW 128
Cdd:PRK10999 264 TIGWKNFTRVFTDegiqkPFIAIFIW-TVVFSLLTVVLTVAVGMVLACLVQWEAlKGKAVYRVLLILPYAVPSFISILIF 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 129 YWLLNPQYGLINRVL-GWFGINgPAWLYDSNWAMFAIVMMSVWMTFgTNMMIFLAG-LQGIPANLYEASKIEGASRWKTF 206
Cdd:PRK10999 343 KGLFNQSFGEINMMLsALFGIK-PAWFSDPTLAKTMILIVNTWLGY-PYMMILCMGlLKAIPDDLYEASAMDGAGPFQNF 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 207 RYVTWPSLSRTtflvTTMLIINAFQV----FDQAYVLTKGGP---GNSTIT-----LVYYIYN---EGFGGLKMGYASAI 271
Cdd:PRK10999 421 FKITLPLLIKP----LTPLMIASFAFnfnnFVLIQLLTNGGPdmiGTTTPAgytdlLVSYTYRiafEGGGGQDFGLAAAI 496

                        250       260
                 ....*....|....*....|
gi 489826277 272 SFVLFLIILVFSIINMRVNK 291
Cdd:PRK10999 497 ATLIFLLVGALAILNLKATK 516
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 14-291 2.18e-16

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 77.07  E-value: 2.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  14 QRMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDIVNSPnWIGF--DNYIKMFRDPYFLISLKNTIIY----TALFVPL 87
Cdd:COG1177    2 SRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTFP-PEGFtlRWYAELFSDPRLLDALLNSLLIallsTLLATVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  88 GLVASLGaaiLINMNKKGAGLFRTFFYVPVLCSTVATATiwywllnpqyGLInRVLGWFGINGpawlydsnwAMFAIVMM 167
Cdd:COG1177   81 GTPAALA---LARYRFRGRRLLLALLLLPLVVPGIVLGV----------ALL-LLFSALGLSG---------GLWGLILA 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 168 SVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPslsrttfLVTTMLIINAFQVF----DQaYVLTK-- 241
Cdd:COG1177  138 HVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLP-------LIAPGILAGALLAFtlsfDE-FVITLfl 209

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 489826277 242 GGPGNSTITLvyYIYNEGFGGLKmGYASAISFVLFLIILVFSIINMRVNK 291
Cdd:COG1177  210 AGPGVTTLPV--YIYSMIRRGIS-PEINALSTLLILLSLLLLLLAERLRR 256
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
15-285 8.44e-15

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 74.43  E-value: 8.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  15 RMAYLFIALPVLLLAIFMILPIGMALFVSFTDYdivnSPNWIGFDNYIKMFRDPYFLISLKNTIIYTALFVPLGLVASLG 94
Cdd:COG1178  285 RWRWLALALCLLLVLLGLLLPLLALLLWSLTKA----LDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALL 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  95 AAILINMNK-KGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGLinrvlgwfgingpaWLYDSNWAMfAIVMMSVWMTF 173
Cdd:COG1178  361 LAYLVRRRRgRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPL--------------LLYGTLAIL-VLAYVVRFLPF 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 174 GTNMMifLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTMLIINAFQVFDQAYVLtkGGPGnsTITLVY 253
Cdd:COG1178  426 ALRSL--EAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLL--RPPG--FETLAV 499

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489826277 254 YIYNEgFGGLKMGYASAISFVLFLIILVFSII 285
Cdd:COG1178  500 LIYQL-ASSGRYGEAAALALLLVLVSLLPVLL 530
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 14-285 2.51e-13

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 68.58  E-value: 2.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  14 QRMAYLFIALPVLLLAIFMILPIGMALFVSFTDYDIVNSPNW------IGFDNYIKMFRDPYFLISLKNTIIYTALFVPL 87
Cdd:COG0395   10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPsllpseFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  88 GL-VASLGAAILINMNKKGAGLFRTFFYVPVLCSTVATATiwywllnPQYGLINRvLGWfgingpawlYDSNWAMfAIVM 166
Cdd:COG0395   90 SLlLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLI-------PLYLLFRQ-LGL---------LNTYWGL-ILPY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 167 MSVWMTFGTnmMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPsLSR----TTFLVTTMLIINAFQVfdqAYVLTkg 242
Cdd:COG0395  152 LAFGLPFGI--FLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLP-LSKpalaTVAIFTFIGAWNDFLW---PLILL-- 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 489826277 243 gPGNSTITLVYYIYN-EGFGGLKMGYASAISFVLFLIILVFSII 285
Cdd:COG0395  224 -TSPDLRTLPVGLASfQGQYGTDWGLLMAAAVIATLPVLILFLF 266
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-280 1.52e-10

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 59.21  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  74 LKNTIIYTALFVPLGLVASLGAAILINMN-KKGAGLFRTFFYVPVLCSTVATATIWYWLLNPQYGlinrvlgwfgingpa 152
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 153 WLYDSNWAMFAIVMMSVWMtFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTMLIINAFQV 232
Cdd:cd06261   66 WGILPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGE 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489826277 233 FDQAYVLtkGGPGNSTITLVYYIYNEGFGGLKMGYASAISFVLFLIIL 280
Cdd:cd06261  145 FALVSFL--GGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 145-285 4.58e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.00  E-value: 4.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  145 WFGINGPAWLYDSNWAMFAIVMMSVWMTFGTNMMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSLSRTTFLVTTM 224
Cdd:pfam00528  36 AILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLAL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489826277  225 LIINAFQVFDQAYVLTKGGPGNSTITLVYYIYNEGFGglkMGYASAISFVLFLIILVFSII 285
Cdd:pfam00528 116 AFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEI---QGPVLAAALILLLLNLLVDIL 173
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 18-214 1.01e-05

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 45.90  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  18 YLFIALPVLLLAIFMILPIGMALFVSFTdydivnspnwIGFDNYIKMFRDPYFLISLKNTI----IYTALFVPLGLVAsl 93
Cdd:COG0555   10 GLTLGLTLLYLSLIVLLPLAALVLKAAG----------LGWAEFWAVLTSPRVLAALKLSLgtalIAALINLVFGLPL-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  94 gAAILINMNKKGAGLFRTFFYVPVLCSTVAtATIWYWLLNPQYGLINRVLGWFGINGPawlydsnwamFAIVMMSVWMTF 173
Cdd:COG0555   78 -AWVLVRYRFPGKRLVDALVDLPFALPTAV-AGIALLLLFGPNGWLGQLLAPLGIKVA----------FTPLGIVLAQTF 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 489826277 174 -GTNMMI--FLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSL 214
Cdd:COG0555  146 vSLPFVVrtVQPVLEELDPELEEAAATLGASRWQTFRRVILPLL 189
thiP PRK09433
thiamine transporter membrane protein; Reviewed
 137-254 1.84e-04

thiamine transporter membrane protein; Reviewed


Pssm-ID: 181853 [Multi-domain]  Cd Length: 525  Bit Score: 42.90  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277 137 GLINRVLGWFGINGPAWLYdsnwAMFAIVMMSVW--MTFGTNMmiFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPSL 214
Cdd:PRK09433 109 GWLAQLLQALGLEWPFSIY----GLQGILLAHVFfnLPLATRL--LLQALESIPAEQRQLAAQLGMRGWQFFRLVEWPYL 182

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489826277 215 SRT---TFLVTTMLIINAFqvfdqAYVLT-KGGPGNSTITLVYY 254
Cdd:PRK09433 183 RRQlppVAALIFMLCFTSF-----ATVLTlGGGPKATTIELAIY 221
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 62-213 1.71e-03

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 38.98  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489826277  62 IKMFRDPYFLISLKNTIIYTALFVPLGLVASLGAAILINMNKKGAGLFRTFF----YVPVlcstVATATIwywllnpqyg 137
Cdd:COG0600   51 VELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLLvflrPIPP----LALAPL---------- 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489826277 138 linrVLGWFGINGPAwlydsnwAMFAIVMMSVWMTFgtnmMIFLAGLQGIPANLYEASKIEGASRWKTFRYVTWPS 213
Cdd:COG0600  117 ----LILWFGIGEAS-------KIFVIFLGAFFPIL----LNTAAGVRSVDPELLELARSLGASRWQILRKVVLPA 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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