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Conserved domains on  [gi|489852052|ref|WP_003755728|]
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MULTISPECIES: iron ABC transporter permease [Neisseriaceae]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 49-348 6.00e-86

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 261.54  E-value: 6.00e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  49 LPVGEVVNVLLGkPEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFG 128
Cdd:COG0609    9 ISLSDVLRALLG-PDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 129 GFGLPetVAVPIGAFVMTMLASGILFLFAS-ARRFNSAMLVLVGIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNK 207
Cdd:COG0609   88 GGLSA--LGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 208 ATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVA 287
Cdd:COG0609  166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489852052 288 RILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:COG0609  246 RLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 49-348 6.00e-86

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 261.54  E-value: 6.00e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  49 LPVGEVVNVLLGkPEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFG 128
Cdd:COG0609    9 ISLSDVLRALLG-PDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 129 GFGLPetVAVPIGAFVMTMLASGILFLFAS-ARRFNSAMLVLVGIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNK 207
Cdd:COG0609   88 GGLSA--LGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 208 ATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVA 287
Cdd:COG0609  166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489852052 288 RILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:COG0609  246 RLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 30-345 4.84e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 203.14  E-value: 4.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052   30 IASVSFLFDIATGPAmtdTLPVGEVVNVLLGKPevDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPY 109
Cdd:pfam01032   1 LLLLLILLSLFIGAV---KISPSDVFSALLGGD--DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  110 TLGLAAAAGLGASVVIAFggFGLPETVAVPIGAFVMTMLASGILFLFASARR-FNSAMLVLVGIALLFLFQSILSLIQFI 188
Cdd:pfam01032  76 ILGISSGAALGAVLAILL--GGSLSLFALPLAAFIGALLAALLVYFLSRGRGgASPLRLILAGIAVSALLSALTSLLLLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  189 AAPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTAT 268
Cdd:pfam01032 154 LNPEALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAA 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489852052  269 AISFVGVIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVL 345
Cdd:pfam01032 234 SVAVVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 65-348 1.32e-42

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 150.49  E-value: 1.32e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  65 DEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFGGFGLPE---TVAVPIG 141
Cdd:PRK03784  47 SPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPwalSLCAIAG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 142 AFVMTMlasgILFLFASARRFNSAMLVLVGIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNKATWETVIVTAAVTA 221
Cdd:PRK03784 127 ALLITL----ILLRFARRHRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 222 VCVLLLSRDVwKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPG 301
Cdd:PRK03784 203 VLIWLCCQGR-PLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPG 281

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489852052 302 AMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:PRK03784 282 CALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSH 328
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 81-344 1.94e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 142.70  E-value: 1.94e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  81 VMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFGGFGLPetVAVPIGAFVMTMLASGILFLFASAR 160
Cdd:cd06550    2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSN--YALGAFAFAGALAIALLVLLLASRG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 161 RFNSAMLVLVGIALLFLFQSILSLIQFIAaPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLG 240
Cdd:cd06550   80 GLSPSKLILIGIVLSAFFSAGVILISLLS-DDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 241 EERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKVI 320
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 489852052 321 IPGALfPVGIVTAFVGVPFFFWIV 344
Cdd:cd06550  239 LPSEL-PVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 49-348 6.00e-86

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 261.54  E-value: 6.00e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  49 LPVGEVVNVLLGkPEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFG 128
Cdd:COG0609    9 ISLSDVLRALLG-PDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 129 GFGLPetVAVPIGAFVMTMLASGILFLFAS-ARRFNSAMLVLVGIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNK 207
Cdd:COG0609   88 GGLSA--LGLPLAAFLGALLAALLVYLLARrGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 208 ATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVA 287
Cdd:COG0609  166 ASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIA 245

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489852052 288 RILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:COG0609  246 RLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 30-345 4.84e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 203.14  E-value: 4.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052   30 IASVSFLFDIATGPAmtdTLPVGEVVNVLLGKPevDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPY 109
Cdd:pfam01032   1 LLLLLILLSLFIGAV---KISPSDVFSALLGGD--DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  110 TLGLAAAAGLGASVVIAFggFGLPETVAVPIGAFVMTMLASGILFLFASARR-FNSAMLVLVGIALLFLFQSILSLIQFI 188
Cdd:pfam01032  76 ILGISSGAALGAVLAILL--GGSLSLFALPLAAFIGALLAALLVYFLSRGRGgASPLRLILAGIAVSALLSALTSLLLLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  189 AAPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTAT 268
Cdd:pfam01032 154 LNPEALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAA 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489852052  269 AISFVGVIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVL 345
Cdd:pfam01032 234 SVAVVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 14-343 5.86e-53

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 178.01  E-value: 5.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  14 RKLEGKRWLIVLMFLIIASVSFLFDIATGPAmtdTLPVGEVVNVLLGkpEVDEMNRLIVMDLRLPIAVMALVVGAALGVG 93
Cdd:COG4779   16 LRLRRRALLVTLVLLLLLLALAVLALTLGDY---PLSPGDVLRALLG--EGDPGASFVVLELRLPRALAALLVGAALGLS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  94 GAEIQTLLNNPMASP---------YTLGLAaaaglgasVVIAFGGFGLpetvAVPIGAFVMTMLASGILFLFASARRFNS 164
Cdd:COG4779   91 GAIFQSLTRNPLASPdiigitagaSAGAVA--------AIVVLGGSGL----AVALGALAGGLATALLVYLLAWRGGVSG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 165 AMLVLVGIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERA 244
Cdd:COG4779  159 YRLILVGIGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 245 VGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDqRFFLPGAMLTGAAFLSVASVLSKVIIPGA 324
Cdd:COG4779  239 AALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPV 317

                        330
                 ....*....|....*....
gi 489852052 325 LFPVGIVTAFVGVPFFFWI 343
Cdd:COG4779  318 QLPVGVVTGALGGPYLLWL 336
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 65-348 1.32e-42

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 150.49  E-value: 1.32e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  65 DEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFGGFGLPE---TVAVPIG 141
Cdd:PRK03784  47 SPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPwalSLCAIAG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 142 AFVMTMlasgILFLFASARRFNSAMLVLVGIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNKATWETVIVTAAVTA 221
Cdd:PRK03784 127 ALLITL----ILLRFARRHRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 222 VCVLLLSRDVwKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPG 301
Cdd:PRK03784 203 VLIWLCCQGR-PLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPG 281

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489852052 302 AMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:PRK03784 282 CALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSH 328
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
72-348 6.18e-41

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 151.92  E-value: 6.18e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  72 VMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPytLGLAAAAGLGASVVIAFGGFGLPETVAVPIGAFVMTMLASG 151
Cdd:PRK10577 393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASP--EVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALA 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 152 ILFLFASARRFNSAMLVLVGIALLFLFQSILSLIQFIAAPEiSQQILFWLFGSLNKATWETVIVTAAVTAVCV---LLLS 228
Cdd:PRK10577 471 LILLLARRGGFAPERLLLTGIALSALFTALIQLLLASGDPR-AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLalaLLLR 549

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 229 RdvwKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAA 308
Cdd:PRK10577 550 R---WLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGAL 626

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 489852052 309 FLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:PRK10577 627 LMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666
btuC PRK09535
cobalamin ABC transporter permease BtuC;
40-343 6.74e-41

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 146.82  E-value: 6.74e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  40 ATGPAMTDTLPVGEVVNVLLGKPEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGL 119
Cdd:PRK09535  59 VPVLSVGLSLPAPDLEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAV 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 120 GASVVIAFggfglpeTVAVPIG----AFVMTMLASGILFLFASAR-RFNSAMLVLVGIALLFLFQSILSLIQFIAAPEIs 194
Cdd:PRK09535 139 GAVAAIVL-------PLAVPFGlqaaAFAGALVAAFGVYAIATENgRTPVATLLLAGVAVQTFLGAVISYLLLHSGESL- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 195 QQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVG 274
Cdd:PRK09535 211 RRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAG 290

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489852052 275 VIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKViiPGALFPVGIVTAFVGVPFFFWI 343
Cdd:PRK09535 291 VIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYL 357
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 81-344 1.94e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 142.70  E-value: 1.94e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  81 VMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFGGFGLPetVAVPIGAFVMTMLASGILFLFASAR 160
Cdd:cd06550    2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSN--YALGAFAFAGALAIALLVLLLASRG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 161 RFNSAMLVLVGIALLFLFQSILSLIQFIAaPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLG 240
Cdd:cd06550   80 GLSPSKLILIGIVLSAFFSAGVILISLLS-DDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 241 EERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKVI 320
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 489852052 321 IPGALfPVGIVTAFVGVPFFFWIV 344
Cdd:cd06550  239 LPSEL-PVGPVTALLGAPYFLYLL 261
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
18-348 1.94e-40

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 150.37  E-value: 1.94e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  18 GKRWLIVLMFLIIASVSFLFDIATGPAMTDTLPVGEVVNVLLGkPEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEI 97
Cdd:PRK10577   5 MSRRRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWG-PDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  98 QTLLNNPMASPYTLGLAAAAGLGASVVIAFGGfGLPETVAVPIgAFVMTMLASGILFLFASARRFNSAMLVLVGIALLFL 177
Cdd:PRK10577  84 QQVLRNPLASPTTLGVAAGAQLALVLATLFAP-ALLALASQLA-AFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 178 FQSILSLIQfIAAPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLK 257
Cdd:PRK10577 162 LGALTTLLL-LFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 258 TLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIP--GALFPVGIVTAFV 335
Cdd:PRK10577 241 ALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGvgGELLPTGAVTALI 320

                        330
                 ....*....|...
gi 489852052 336 GVPFFFWIVLSKR 348
Cdd:PRK10577 321 GAPLLLWLLPRLR 333
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
64-348 6.19e-36

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 132.48  E-value: 6.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  64 VDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPytLGLAAAAGLGASVVIAFGGFGLPETVAVPIGAF 143
Cdd:PRK09777  39 AGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASP--DILGVNHAASLASVGALLLFPSLPVMWLPLLAF 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 144 VMTMLASGILFLFASarrFNSAM-LVLVGIALLFLFQSILSLIQFIAAPEISQQILfWLFGSLNKATWETVIVTAAVTAV 222
Cdd:PRK09777 117 IGGMAGLILLKMLAG---THQPMkLALTGVALSALWASLTDYLMLSRPQDINNALL-WLTGSLWGRDWSFVKVALPWLIL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 223 CVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRFFLPGA 302
Cdd:PRK09777 193 LLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVS 272

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 489852052 303 MLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:PRK09777 273 ALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
64-348 1.24e-33

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 126.35  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  64 VDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIA-----FGGFGLPETVAV 138
Cdd:PRK11228  39 TPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSAlsptpFAGYSLAFIAAC 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 139 PIG-AFVMTMLASGilflfASARRFNSAMLVLVGIALLfLFQSILSLIQFIAAPEISQQILFWLFGSLNKATWETVIVTA 217
Cdd:PRK11228 119 GGGlSWLLVMTAGG-----GWRHTHDRNRLILAGIALS-ALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 218 AVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEDQRF 297
Cdd:PRK11228 193 PFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRN 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489852052 298 FLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:PRK11228 273 VLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRRG 323
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
49-348 3.05e-32

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 122.89  E-value: 3.05e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  49 LPVGEVVNVLLGkpEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEIQTLLNNPMASPYTLGLAAAAGLGASVVIAFG 128
Cdd:PRK10441  35 LPASVVLEALSG--TCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 129 GFGLPETVAVPigAFVMTMLASGILFLFAS--ARRFNSAMLVLVGIALLFLFQSILSLIQFIAaPEISQQILFWLFGSLN 206
Cdd:PRK10441 113 GYSSAQEQLAM--AFAGALVASLIVAFTGSqgGGQLSPVRLTLAGVALAAVLEGLTSGIALLN-PDVYDQLRFWQAGSLD 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 207 KATWETVIVTAAVT---AVCVLLLSRdvwKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGLVA 283
Cdd:PRK10441 190 IRNLHTLKVVLIPVliaGATALLLSR---ALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMM 266

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489852052 284 PHVARILLGEDQRFFLPGAMLTGAAFLSVASVLSKVIIPGALfPVGIVTAFVGVPFFFWIVLSKR 348
Cdd:PRK10441 267 PHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLVPGEL-RVSVVSAFIGAPVLIFLVRRKT 330
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
19-345 1.12e-26

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 107.87  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  19 KRWLIVLMFLIIASVSF-LFDIATGPAmtdTLPVGEVVNVLLGkpEVDEMNRLIVMDLRLPIAVMALVVGAALGVGGAEI 97
Cdd:PRK10440   6 RRLLITCLLLLAACVAAgLWGLRSGAV---TLETSQVFAALMG--DAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  98 QTLLNNPMASPYTLGLAAAAGLGASVVIAFGGFGLpetVAVPIGAFVMTMLASGILFLFASARRFNSAMLVLVGIALLFL 177
Cdd:PRK10440  81 QSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDL---TAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAM 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 178 FQSILSLIQFIAAPEISQQILFWLFGSLNKATWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLK 257
Cdd:PRK10440 158 LVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 258 TLVLVAVMTATAISFVGVIGFIGLVAPHVARILLGEdQRFFLPGAMLTGAAFLSVASVLSKVIIPGALFPVGIVTAFVGV 337
Cdd:PRK10440 238 LMLVAVVLTAAATALAGPISFIALVAPHIARRLSGT-ARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGG 316


                 ....*...
gi 489852052 338 PFFFWIVL 345
Cdd:PRK10440 317 IYLIVLLI 324
ABC-3 pfam00950
ABC 3 transport family;
129-317 7.14e-05

ABC 3 transport family;


Pssm-ID: 334323  Cd Length: 258  Bit Score: 43.76  E-value: 7.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  129 GFGLPETVAVPIGAFVMTMLASgiLFLFASARRFNSAMLVLVGIALLFLFQsiLSLIQFIAAPEISQQILFWLFGSLNKA 208
Cdd:pfam00950  47 ALAYFLGINPAIGAFVFGLIAA--VAMGYLKRKTRLKEDTAIGIVFSTFLA--LGLVLISLIPGSAVDLDSYLFGNILTI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052  209 TWETVIVTAAVTAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIG-LVAPHVA 287
Cdd:pfam00950 123 SQQDLIQIAIITAVILILLLLFWKELLLITFDPDHAKVIGLPVQFLYLLLLALIALTIVVALQAVGAILVIAlLIIPAAT 202

                         170       180       190
                  ....*....|....*....|....*....|
gi 489852052  288 RILLGEDQRFFLPGAMLTGAAFLSVASVLS 317
Cdd:pfam00950 203 ARRLTRSFDSMLIIAILIGMVSCVAGLYLS 232
ZnuB COG1108
ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and ...
 140-317 2.99e-04

ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440725  Cd Length: 260  Bit Score: 41.96  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 140 IGAFVMTMLASGILFLFASARRFNSAMLvlvgIALLFLFQSILSLIQFIAAPEISQQILFWLFGSLNKATWETVIVTAAV 219
Cdd:COG1108   57 LGALVAGLLAALLIGLLRRRSRLKEDTA----IGIVFSGGFALGVLLISLVPGSAVDLMSYLFGSILAVSRSDLLLLAVL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489852052 220 TAVCVLLLSRDVWKLTALRLGEERAVGLGINLQLLRLKTLVLVAVMTATAISFVGVIGFIGL-VAPHVARILLGEDqrff 298
Cdd:COG1108  133 AAVVLLLLLLFYRELLLVSFDPELARASGLPVRLLHLLLLVLLALTVVAALQAVGALLVSALlIIPAATARLLTRS---- 208

                        170
                 ....*....|....*....
gi 489852052 299 lPGAMLTGAAFLSVASVLS 317
Cdd:COG1108  209 -LRRMLLLAVLIGVLSSVL 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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