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Conserved domains on  [gi|489863449|ref|WP_003767061|]
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MULTISPECIES: primosomal protein DnaI [Listeria]

Protein Classification

primosomal protein DnaI( domain architecture ID 11483475)

primosomal protein DnaI is involved in DNA replication and interacts with the main replicative DNA helicase DnaB; belongs to the AAA+ ATPase family and functions in loading the hexameric helicase ring onto ssDNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 1-306 1.94e-170

primosomal protein DnaI; Reviewed


:

Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 474.36  E-value: 1.94e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449   1 MDNIERTLGQLFEGRDFEKEYQGLKQQVLHYQPIQDFFKENKEDITEQLINQNLSNLYEFMTQHKKFTEQEETLMPGYAP 80
Cdd:PRK08939   1 MESIGKTLKKLMKRQDFRKRYEKLKQEVLADPDVQAFLQEHQEELTQEMIDRSLSKLYEYIDQRKKCDRGCPNYAKGYQP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  81 KLVLNGEFITVTYYPTKEKIEEDKRRAVERRIRSLYMPKQVVDANLADFYTDEESRKLALVEAYQFLNNYPPqnGERVKG 160
Cdd:PRK08939  81 KLVMNGGYIDVSYLPTPEKIEADEEKAIKKRIQSIYMPKDLLQASLADIDLDDRDRLDALMAALDFLEAYPP--GEKVKG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFAKETEVLMLDDIGAESMTAWTRDE 240
Cdd:PRK08939 159 LYLYGDFGVGKSYLLAAIANELAKKGVSSTLLHFPEFIRELKNSISDGSVKEKIDAVKEAPVLMLDDIGAEQMSSWVRDE 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489863449 241 VLGAILQFRMQEELPTFFSSNYNMDQLENHLMFAQNGTEEKLKARRIMERVRYLSKEVNLEGKNRR 306
Cdd:PRK08939 239 VLGVILQYRMQEELPTFFTSNFDFDELEHHLAYTQRGEDETWKAARIMERIRYLAKEVHLEGKNRR 304
 
Name Accession Description Interval E-value
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 1-306 1.94e-170

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 474.36  E-value: 1.94e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449   1 MDNIERTLGQLFEGRDFEKEYQGLKQQVLHYQPIQDFFKENKEDITEQLINQNLSNLYEFMTQHKKFTEQEETLMPGYAP 80
Cdd:PRK08939   1 MESIGKTLKKLMKRQDFRKRYEKLKQEVLADPDVQAFLQEHQEELTQEMIDRSLSKLYEYIDQRKKCDRGCPNYAKGYQP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  81 KLVLNGEFITVTYYPTKEKIEEDKRRAVERRIRSLYMPKQVVDANLADFYTDEESRKLALVEAYQFLNNYPPqnGERVKG 160
Cdd:PRK08939  81 KLVMNGGYIDVSYLPTPEKIEADEEKAIKKRIQSIYMPKDLLQASLADIDLDDRDRLDALMAALDFLEAYPP--GEKVKG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFAKETEVLMLDDIGAESMTAWTRDE 240
Cdd:PRK08939 159 LYLYGDFGVGKSYLLAAIANELAKKGVSSTLLHFPEFIRELKNSISDGSVKEKIDAVKEAPVLMLDDIGAEQMSSWVRDE 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489863449 241 VLGAILQFRMQEELPTFFSSNYNMDQLENHLMFAQNGTEEKLKARRIMERVRYLSKEVNLEGKNRR 306
Cdd:PRK08939 239 VLGVILQYRMQEELPTFFTSNFDFDELEHHLAYTQRGEDETWKAARIMERIRYLAKEVHLEGKNRR 304
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
43-307 4.05e-49

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 163.41  E-value: 4.05e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  43 EDITEQLINQNLSNLYEFMTQHKkftEQEETLMPGYApklvlngEFItvtYYPTKEKIEEDKRRAVERRIRSLYMPkqvV 122
Cdd:COG1484    4 EELKELLKALKLPGMAEALDELL---AQAACDELSYE-------EFL---ALLLEAEVAEREQRRIERRLKAARFP---A 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 123 DANLADFYTDEE---SRKLALVEAY-QFLnnyppqngERVKGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFM 198
Cdd:COG1484   68 AKTLEDFDFDAQpglDRRQILELATlDFI--------ERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLV 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 199 REVKQSISDNTVGEKIQFAKETEVLMLDDIGAESMTAWTRDEvLGAILQFRMqEELPTFFSSNYNMDQLENHLMfaqngt 278
Cdd:COG1484  140 NELKEARADGRLERLLKRLAKVDLLILDELGYLPLDAEGAEL-LFELISDRY-ERRSTIITSNLPFSEWGEVFG------ 211

                        250       260
                 ....*....|....*....|....*....
gi 489863449 279 eEKLKARRIMERVRYLSKEVNLEGKNRRF 307
Cdd:COG1484  212 -DPTLATAILDRLVHHAHIIELKGESYRL 239
DnaI_N pfam07319
Primosomal protein DnaI N-terminus; This family represents the N-terminus (approximately 120 ...
 1-89 8.76e-29

Primosomal protein DnaI N-terminus; This family represents the N-terminus (approximately 120 residues) of bacterial primosomal DnaI proteins, although one family member appears to be of viral origin. DnaI is one of the components of the Bacillus subtilis replication restart primosome, and is required for the DnaB75-dependent loading of the DnaC helicase.


Pssm-ID: 429407  Cd Length: 90  Bit Score: 105.74  E-value: 8.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449    1 MDNIERTLGQLFEGRDFEKEYQGLKQQVLHYQPIQDFFKENKEDITEQLINQNLSNLYEFMTQHKKFT-EQEETLMPGYA 79
Cdd:pfam07319   1 MESIGETLKKLMKRRNFRKRYEKLKEEVLSDPDVQAFLQEHPEELTQEMIDRSLSKLYEYVSQKKKCEnGDCPNIAPGYQ 80

                          90
                  ....*....|
gi 489863449   80 PKLVLNGEFI 89
Cdd:pfam07319  81 PKLVLNGGYI 90
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 159-268 3.29e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.07  E-value: 3.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 159 KGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFAK----ETEVLMLDDIGaeSMT 234
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELaekaKPGVLFIDEID--SLS 97

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489863449 235 AWTRDEVLGAILQF----RMQEELPTFFSSNYNMDQLE 268
Cdd:cd00009   98 RGAQNALLRVLETLndlrIDRENVRVIGATNRPLLGDL 135
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 161-228 3.69e-05

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 44.83  E-value: 3.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLP--EFMREVKQSISDNTVGEKIQFAKETEVLMLDDI 228
Cdd:TIGR00362 140 LFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSseKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDI 209
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 159-274 4.78e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.97  E-value: 4.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449   159 KGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEK-------------IQFAKE--TEVL 223
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKkasgsgelrlrlaLALARKlkPDVL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 489863449   224 MLDDIGAESMTAWTRDEVLGAILQFRMQEELPT----FFSSNYNMDQLENHLMFA 274
Cdd:smart00382  83 ILDEITSLLDAEQEALLLLLEELRLLLLLKSEKnltvILTTNDEKDLGPALLRRR 137
 
Name Accession Description Interval E-value
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 1-306 1.94e-170

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 474.36  E-value: 1.94e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449   1 MDNIERTLGQLFEGRDFEKEYQGLKQQVLHYQPIQDFFKENKEDITEQLINQNLSNLYEFMTQHKKFTEQEETLMPGYAP 80
Cdd:PRK08939   1 MESIGKTLKKLMKRQDFRKRYEKLKQEVLADPDVQAFLQEHQEELTQEMIDRSLSKLYEYIDQRKKCDRGCPNYAKGYQP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  81 KLVLNGEFITVTYYPTKEKIEEDKRRAVERRIRSLYMPKQVVDANLADFYTDEESRKLALVEAYQFLNNYPPqnGERVKG 160
Cdd:PRK08939  81 KLVMNGGYIDVSYLPTPEKIEADEEKAIKKRIQSIYMPKDLLQASLADIDLDDRDRLDALMAALDFLEAYPP--GEKVKG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFAKETEVLMLDDIGAESMTAWTRDE 240
Cdd:PRK08939 159 LYLYGDFGVGKSYLLAAIANELAKKGVSSTLLHFPEFIRELKNSISDGSVKEKIDAVKEAPVLMLDDIGAEQMSSWVRDE 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489863449 241 VLGAILQFRMQEELPTFFSSNYNMDQLENHLMFAQNGTEEKLKARRIMERVRYLSKEVNLEGKNRR 306
Cdd:PRK08939 239 VLGVILQYRMQEELPTFFTSNFDFDELEHHLAYTQRGEDETWKAARIMERIRYLAKEVHLEGKNRR 304
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
43-307 4.05e-49

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 163.41  E-value: 4.05e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  43 EDITEQLINQNLSNLYEFMTQHKkftEQEETLMPGYApklvlngEFItvtYYPTKEKIEEDKRRAVERRIRSLYMPkqvV 122
Cdd:COG1484    4 EELKELLKALKLPGMAEALDELL---AQAACDELSYE-------EFL---ALLLEAEVAEREQRRIERRLKAARFP---A 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 123 DANLADFYTDEE---SRKLALVEAY-QFLnnyppqngERVKGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFM 198
Cdd:COG1484   68 AKTLEDFDFDAQpglDRRQILELATlDFI--------ERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLV 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 199 REVKQSISDNTVGEKIQFAKETEVLMLDDIGAESMTAWTRDEvLGAILQFRMqEELPTFFSSNYNMDQLENHLMfaqngt 278
Cdd:COG1484  140 NELKEARADGRLERLLKRLAKVDLLILDELGYLPLDAEGAEL-LFELISDRY-ERRSTIITSNLPFSEWGEVFG------ 211

                        250       260
                 ....*....|....*....|....*....
gi 489863449 279 eEKLKARRIMERVRYLSKEVNLEGKNRRF 307
Cdd:COG1484  212 -DPTLATAILDRLVHHAHIIELKGESYRL 239
DnaI_N pfam07319
Primosomal protein DnaI N-terminus; This family represents the N-terminus (approximately 120 ...
 1-89 8.76e-29

Primosomal protein DnaI N-terminus; This family represents the N-terminus (approximately 120 residues) of bacterial primosomal DnaI proteins, although one family member appears to be of viral origin. DnaI is one of the components of the Bacillus subtilis replication restart primosome, and is required for the DnaB75-dependent loading of the DnaC helicase.


Pssm-ID: 429407  Cd Length: 90  Bit Score: 105.74  E-value: 8.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449    1 MDNIERTLGQLFEGRDFEKEYQGLKQQVLHYQPIQDFFKENKEDITEQLINQNLSNLYEFMTQHKKFT-EQEETLMPGYA 79
Cdd:pfam07319   1 MESIGETLKKLMKRRNFRKRYEKLKEEVLSDPDVQAFLQEHPEELTQEMIDRSLSKLYEYVSQKKKCEnGDCPNIAPGYQ 80

                          90
                  ....*....|
gi 489863449   80 PKLVLNGEFI 89
Cdd:pfam07319  81 PKLVLNGGYI 90
PRK08116 PRK08116
hypothetical protein; Validated
 98-306 1.15e-20

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 89.31  E-value: 1.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  98 EKIEEDKRRAVERRIRSL----YMPKQVVDANLADFYTDEESRKLALVeAYQFLNNYPPQNGERVkGLFIHGSFGTGKSY 173
Cdd:PRK08116  52 AKEREEENREKQRRIERLksnsLLDEKFRNSTFENFLFDKGSEKAYKI-ARKYVKKFEEMKKENV-GLLLWGSVGTGKTY 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 174 LLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFA---KETEVLMLDDIGAESMTAWTRDEVLGaILQFRM 250
Cdd:PRK08116 130 LAACIANELIEKGVPVIFVNFPQLLNRIKSTYKSSGKEDENEIIrslVNADLLILDDLGAERDTEWAREKVYN-IIDSRY 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489863449 251 QEELPTFFSSNYNMDQLENhlmfaqngteeKLKAR---RIMERvrylSKEVNLEGKNRR 306
Cdd:PRK08116 209 RKGLPTIVTTNLSLEELKN-----------QYGKRiydRILEM----CTPVENEGKSYR 252
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 61-292 1.83e-08

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 54.00  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  61 MTQHKKFTEQEETLMPGYA-PKLVLNGEFITVTYYPTK---EKIEEDKRRAVERR------IRSLYMpkqvvDANLADFY 130
Cdd:PRK07952   1 MKNVGDLMQRLQKMMPAHIkPAFKTGEELLAWQKEQGRirsAALERENRAMKMQRtfnrsgIRPLHQ-----NCSFENYR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 131 TDEESRKLALVEAYQFLNNYppqnGERVKGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTV 210
Cdd:PRK07952  76 VECEGQMNALSKARQYVEEF----DGNIASFIFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSAMKDTFSNSET 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 211 GEK--IQFAKETEVLMLDDIGAESMTAWTRdEVLGAILQFRMQEELPTFFSSNYNMDQLenhlmfaqngteEKLKARRIM 288
Cdd:PRK07952 152 SEEqlLNDLSNVDLLVIDEIGVQTESRYEK-VIINQIVDRRSSSKRPTGMLTNSNMEEM------------TKLLGERVM 218


                 ....
gi 489863449 289 ERVR 292
Cdd:PRK07952 219 DRMR 222
PRK06921 PRK06921
hypothetical protein; Provisional
 107-267 2.28e-08

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 54.01  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 107 AVERRIRSLYMPKQVVDA----NLADFYTdeESRKLALVEAYQ----FLNNYPPQNGERVKGLFIHGSFGTGKSYLLGAL 178
Cdd:PRK06921  60 VEQRKIERLLKASEITEAfrklTFKNFKT--EGKPQAIKDAYEcaveYVKDFEKIQESRKNSIALLGQPGSGKTHLLTAA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 179 AKELaLKGISTTLVYLP--EFMREVKQSISdnTVGEKIQFAKETEVLMLDDI-----GAESMTAWtRDEVLGAILQFRMQ 251
Cdd:PRK06921 138 ANEL-MRKKGVPVLYFPfvEGFGDLKDDFD--LLEAKLNRMKKVEVLFIDDLfkpvnGKPRATEW-QIEQMYSVLNYRYL 213

                        170
                 ....*....|....*.
gi 489863449 252 EELPTFFSSNYNMDQL 267
Cdd:PRK06921 214 NHKPILISSELTIDEL 229
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
161-228 6.26e-08

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 52.89  E-value: 6.26e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLP--EFMREVKQSISDNTVGEKIQFAKETEVLMLDDI 228
Cdd:COG0593   37 LFLYGGVGLGKTHLLHAIGNEALENNPGARVVYLTaeEFTNDFINAIRNNTIEEFKEKYRSVDVLLIDDI 106
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 159-269 1.12e-07

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 52.21  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 159 KGLFIHGSFGTGKSYLLGALAKELALKGisTTLVYL--PEFM---REVKQSiSDNTVGEKIQFAKETEVLMLDDIGAESM 233
Cdd:PRK06835 184 ENLLFYGNTGTGKTFLSNCIAKELLDRG--KSVIYRtaDELIeilREIRFN-NDKELEEVYDLLINCDLLIIDDLGTEKI 260

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489863449 234 TAWTRDEvLGAILQFRMQEELPTFFSSNYNMDQLEN 269
Cdd:PRK06835 261 TEFSKSE-LFNLINKRLLRQKKMIISTNLSLEELLK 295
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 159-268 3.29e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.07  E-value: 3.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 159 KGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFAK----ETEVLMLDDIGaeSMT 234
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELaekaKPGVLFIDEID--SLS 97

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489863449 235 AWTRDEVLGAILQF----RMQEELPTFFSSNYNMDQLE 268
Cdd:cd00009   98 RGAQNALLRVLETLndlrIDRENVRVIGATNRPLLGDL 135
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 161-228 3.69e-05

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 44.83  E-value: 3.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLP--EFMREVKQSISDNTVGEKIQFAKETEVLMLDDI 228
Cdd:TIGR00362 140 LFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSseKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDI 209
Bac_DnaA pfam00308
Bacterial dnaA protein;
161-228 7.07e-05

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 43.09  E-value: 7.07e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449  161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLP--EFMREVKQSISDNTVGEKIQFAKETEVLMLDDI 228
Cdd:pfam00308  37 LFIYGGVGLGKTHLLHAIGNYALQNAPNLRVVYLTaeEFLNDFVDAIRDNKTNQFKEKYRNVDVLLIDDI 106
dnaA PRK00149
chromosomal replication initiator protein DnaA;
161-228 1.38e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 43.20  E-value: 1.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 161 LFIHGSFGTGKSYLLGALAKELALKGISTTLVYLP--EFMREVKQSISDNTVGEKIQFAKETEVLMLDDI 228
Cdd:PRK00149 102 LFIYGGVGLGKTHLLHAIGNYILEKNPNAKVVYVTseKFTNDFVNALRNNTMEEFKEKYRSVDVLLIDDI 171
dnaA PRK14086
chromosomal replication initiator protein DnaA;
161-228 9.70e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.58  E-value: 9.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489863449 161 LFIHGSFGTGKSYLLGAL---AKELaLKGISTTLVYLPEFMREVKQSISDntvGEKIQFAK---ETEVLMLDDI 228
Cdd:PRK14086 317 LFIYGESGLGKTHLLHAIghyARRL-YPGTRVRYVSSEEFTNEFINSIRD---GKGDSFRRryrEMDILLVDDI 386
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 159-274 4.78e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.97  E-value: 4.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449   159 KGLFIHGSFGTGKSYLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEK-------------IQFAKE--TEVL 223
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKkasgsgelrlrlaLALARKlkPDVL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 489863449   224 MLDDIGAESMTAWTRDEVLGAILQFRMQEELPT----FFSSNYNMDQLENHLMFA 274
Cdd:smart00382  83 ILDEITSLLDAEQEALLLLLEELRLLLLLKSEKnltvILTTNDEKDLGPALLRRR 137
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 159-248 5.89e-03

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 36.88  E-value: 5.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449 159 KGLFIHGSFGTGKSYLLGALAKELalkGISTTLVYLPEFM-REVKQSISDntVGEKIQFAKETE--VLMLDDI------- 228
Cdd:cd19481   27 KGILLYGPPGTGKTLLAKALAGEL---GLPLIVVKLSSLLsKYVGESEKN--LRKIFERARRLApcILFIDEIdaigrkr 101

                         90       100
                 ....*....|....*....|
gi 489863449 229 GAESMTAWTRdEVLGAILQF 248
Cdd:cd19481  102 DSSGESGELR-RVLNQLLTE 120
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 97-229 7.02e-03

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 37.42  E-value: 7.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489863449   97 KEKIEEDKRRaVERRIRSLYMPKQvvdANLADF----YTDEESRKLALVEAYQFLnnyppqngERVKGLFIHGSFGTGKS 172
Cdd:pfam01695  39 EELAWRDTRR-LERLLRMAKLPPH---KTLEDFdftfAPGLDQRIVAELASLSFI--------DRAQNVVLLGPPGVGKT 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489863449  173 YLLGALAKELALKGISTTLVYLPEFMREVKQSISDNTVGEKIQFAKETEVLMLDDIG 229
Cdd:pfam01695 107 HLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRKLQQLLKPDVLILDEWG 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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