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Conserved domains on  [gi|489867546|ref|WP_003771126|]
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MULTISPECIES: RsbT co-antagonist protein RsbRA [Listeria]

Protein Classification

RsbT co-antagonist protein RsbRA( domain architecture ID 14443737)

RsbT co-antagonist protein RsbRA functions in the environmental signaling branch of the general stress response; acts as a positive regulator of sigma-B activity in response to salt and heat stress by stimulating the activity of the RsbT kinase toward RsbS

CATH:  3.30.750.24|1.10.490.10
Gene Ontology:  GO:0043856
PubMed:  16319496|10662676|22116355|32863222|16061809|19281958
SCOP:  4003567|3000554

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsbR_N-like cd19413
globin-like domain of positive regulator of sigma-B activity (RsbRA); The globin-like domain ...
 5-140 1.87e-53

globin-like domain of positive regulator of sigma-B activity (RsbRA); The globin-like domain of Bacillus subtilis RsbRA is a non-heme globin presumed to channel sensory input to the C-terminal sulfate transporter/anti-sigma factor antagonist (STAT) domain. RsbRA is a component of the sigma B-activating stressosome, and a regulator of the RNA polymerase sigma factor subunit sigma (B).


:

Pssm-ID: 381292  Cd Length: 132  Bit Score: 170.14  E-value: 1.87e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546   5 FANFIRTNKKDLLNNWMNEMEKQSDPLINDIAKEPMYEETSIEFVDLIVSNITENGSKFNEKLDDFAEKVVHLGWPIHFV 84
Cdd:cd19413    1 VAQFIQENRDEILERWEEELKDLSSERSLQIISDEVYENTSREFIDLILSNISEDNEKFEERLDEFAEKVVQLGWPLKYL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489867546  85 TTGLRVFGLLVYTAMRDEDLflkrEEKPEDDAYYRFETWLSSMYNKVVTAYADTWE 140
Cdd:cd19413   81 TKGLQEFRKVVYELMNEEEL----TDQQSLELFYEFDEWIDPIRNEIVNQYSGSWE 132
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 154-262 8.34e-45

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


:

Pssm-ID: 132912  Cd Length: 109  Bit Score: 146.83  E-value: 8.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546 154 SAPLLPIFEKISVMPLIGTIDTERAKLIIENLLIGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVG 233
Cdd:cd07041    1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                         90       100
                 ....*....|....*....|....*....
gi 489867546 234 IRPEIAQTIVNLGIELDQIITTNTMKKGM 262
Cdd:cd07041   81 IRPEVAQTLVELGIDLSGIRTAATLQQAL 109
 
Name Accession Description Interval E-value
RsbR_N-like cd19413
globin-like domain of positive regulator of sigma-B activity (RsbRA); The globin-like domain ...
 5-140 1.87e-53

globin-like domain of positive regulator of sigma-B activity (RsbRA); The globin-like domain of Bacillus subtilis RsbRA is a non-heme globin presumed to channel sensory input to the C-terminal sulfate transporter/anti-sigma factor antagonist (STAT) domain. RsbRA is a component of the sigma B-activating stressosome, and a regulator of the RNA polymerase sigma factor subunit sigma (B).


Pssm-ID: 381292  Cd Length: 132  Bit Score: 170.14  E-value: 1.87e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546   5 FANFIRTNKKDLLNNWMNEMEKQSDPLINDIAKEPMYEETSIEFVDLIVSNITENGSKFNEKLDDFAEKVVHLGWPIHFV 84
Cdd:cd19413    1 VAQFIQENRDEILERWEEELKDLSSERSLQIISDEVYENTSREFIDLILSNISEDNEKFEERLDEFAEKVVQLGWPLKYL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489867546  85 TTGLRVFGLLVYTAMRDEDLflkrEEKPEDDAYYRFETWLSSMYNKVVTAYADTWE 140
Cdd:cd19413   81 TKGLQEFRKVVYELMNEEEL----TDQQSLELFYEFDEWIDPIRNEIVNQYSGSWE 132
Rsbr_N pfam08678
Rsbr N terminal; Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B). The ...
 9-140 1.35e-48

Rsbr N terminal; Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B). The structure of the N terminal domain belongs to the globin fold superfamily.


Pssm-ID: 400838  Cd Length: 130  Bit Score: 157.47  E-value: 1.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546    9 IRTNKKDLLNNWMNEMEKQSDPLINDIAKEPMYEETSIEFVDLIVSNITENGSKFNEKLDDFAEKVVHLGWPIHFVTTGL 88
Cdd:pfam08678   1 ILENKDELLKEWLKELKELRSEEYLQTISDDVYENTSREFVDLIFSSIEEGNEEFEEKLDDFSERLVQLGWPLKYLTTGL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489867546   89 RVFGLLVYTAMRDEdLFLKREEKpEDDAYYRFETWLSSMYNKVVTAYADTWE 140
Cdd:pfam08678  81 QEFRKVVYTFMNDQ-SDVIDEQQ-SLELIWEIEEWIDPIINEIVNQYSGSWE 130
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 154-262 8.34e-45

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 146.83  E-value: 8.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546 154 SAPLLPIFEKISVMPLIGTIDTERAKLIIENLLIGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVG 233
Cdd:cd07041    1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                         90       100
                 ....*....|....*....|....*....
gi 489867546 234 IRPEIAQTIVNLGIELDQIITTNTMKKGM 262
Cdd:cd07041   81 IRPEVAQTLVELGIDLSGIRTAATLQQAL 109
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 158-248 3.30e-18

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 77.59  E-value: 3.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546 158 LPIFEKISVMPLIGTIDTERAKLIIENLLiGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVGIRPE 237
Cdd:COG1366    4 VEVRDGVLVLPLIGELDAARAPELREALL-EALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82

                         90
                 ....*....|.
gi 489867546 238 IAQTIVNLGIE 248
Cdd:COG1366   83 VARVLELTGLD 93
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 155-255 8.25e-16

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 71.49  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546  155 APLLPIFEKISVMPLIGTIDTERAKLIIENLLIGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVGI 234
Cdd:pfam01740   1 YPEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGP 80

                          90       100
                  ....*....|....*....|.
gi 489867546  235 RPEIAQTIVNLGieLDQIITT 255
Cdd:pfam01740  81 SPEVARTLEKTG--LDDIIKI 99
 
Name Accession Description Interval E-value
RsbR_N-like cd19413
globin-like domain of positive regulator of sigma-B activity (RsbRA); The globin-like domain ...
 5-140 1.87e-53

globin-like domain of positive regulator of sigma-B activity (RsbRA); The globin-like domain of Bacillus subtilis RsbRA is a non-heme globin presumed to channel sensory input to the C-terminal sulfate transporter/anti-sigma factor antagonist (STAT) domain. RsbRA is a component of the sigma B-activating stressosome, and a regulator of the RNA polymerase sigma factor subunit sigma (B).


Pssm-ID: 381292  Cd Length: 132  Bit Score: 170.14  E-value: 1.87e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546   5 FANFIRTNKKDLLNNWMNEMEKQSDPLINDIAKEPMYEETSIEFVDLIVSNITENGSKFNEKLDDFAEKVVHLGWPIHFV 84
Cdd:cd19413    1 VAQFIQENRDEILERWEEELKDLSSERSLQIISDEVYENTSREFIDLILSNISEDNEKFEERLDEFAEKVVQLGWPLKYL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489867546  85 TTGLRVFGLLVYTAMRDEDLflkrEEKPEDDAYYRFETWLSSMYNKVVTAYADTWE 140
Cdd:cd19413   81 TKGLQEFRKVVYELMNEEEL----TDQQSLELFYEFDEWIDPIRNEIVNQYSGSWE 132
Rsbr_N pfam08678
Rsbr N terminal; Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B). The ...
 9-140 1.35e-48

Rsbr N terminal; Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B). The structure of the N terminal domain belongs to the globin fold superfamily.


Pssm-ID: 400838  Cd Length: 130  Bit Score: 157.47  E-value: 1.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546    9 IRTNKKDLLNNWMNEMEKQSDPLINDIAKEPMYEETSIEFVDLIVSNITENGSKFNEKLDDFAEKVVHLGWPIHFVTTGL 88
Cdd:pfam08678   1 ILENKDELLKEWLKELKELRSEEYLQTISDDVYENTSREFVDLIFSSIEEGNEEFEEKLDDFSERLVQLGWPLKYLTTGL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489867546   89 RVFGLLVYTAMRDEdLFLKREEKpEDDAYYRFETWLSSMYNKVVTAYADTWE 140
Cdd:pfam08678  81 QEFRKVVYTFMNDQ-SDVIDEQQ-SLELIWEIEEWIDPIINEIVNQYSGSWE 130
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 154-262 8.34e-45

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 146.83  E-value: 8.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546 154 SAPLLPIFEKISVMPLIGTIDTERAKLIIENLLIGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVG 233
Cdd:cd07041    1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                         90       100
                 ....*....|....*....|....*....
gi 489867546 234 IRPEIAQTIVNLGIELDQIITTNTMKKGM 262
Cdd:cd07041   81 IRPEVAQTLVELGIDLSGIRTAATLQQAL 109
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 158-248 3.30e-18

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 77.59  E-value: 3.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546 158 LPIFEKISVMPLIGTIDTERAKLIIENLLiGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVGIRPE 237
Cdd:COG1366    4 VEVRDGVLVLPLIGELDAARAPELREALL-EALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82

                         90
                 ....*....|.
gi 489867546 238 IAQTIVNLGIE 248
Cdd:COG1366   83 VARVLELTGLD 93
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 155-255 8.25e-16

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 71.49  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489867546  155 APLLPIFEKISVMPLIGTIDTERAKLIIENLLIGVVKNRSEVVLIDITGVPVVDTMVAHHIIQASEAVRLVGCQAMLVGI 234
Cdd:pfam01740   1 YPEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGP 80

                          90       100
                  ....*....|....*....|.
gi 489867546  235 RPEIAQTIVNLGieLDQIITT 255
Cdd:pfam01740  81 SPEVARTLEKTG--LDDIIKI 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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