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Conserved domains on  [gi|489904844|ref|WP_003808272|]
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type VI secretion system tip protein VgrG [Bordetella bronchiseptica]

Protein Classification

type VI secretion system tip protein VgrG( domain architecture ID 12859174)

type VI secretion system tip protein VgrG, a core component and effector of type VI secretion systems (T6SSs) that are involved in pathogenicity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VI_Rhs_Vgr TIGR03361
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
 16-525 0e+00

type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.


:

Pssm-ID: 274542 [Multi-domain]  Cd Length: 513  Bit Score: 770.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   16 TPLPPQALQFRSMHGHEGLSALYEFEVDLLAATHTLELKSLLGKPVSLEIE-TGGAPRYLSGQATRCALVGregDSARQY 94
Cdd:TIGR03361   5 TPLGPDALQVLSFSGDEALSRLFSFRLELVSADPDIDLEDLLGQPATLTLGrDGGGPRYFHGIVTRFEQGG---TGRRLT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   95 VYRVTMRPWLWYLTQTSDSKIFQQMSVVDVLRQVLADYPF-PVEYRLAGSYRRWEYCVQYQETDFAFVSRLMEHEGIYYW 173
Cdd:TIGR03361  82 RYRLTLVPWLWLLTLRRDSRIFQNKSVPEIITEVLKEHGItDFRFRLSKSYPPREYCVQYRESDLDFVSRLLEEEGIFYY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  174 FRHESGRHTLVLTDDITQHDECPGAaQLPYYgPDRATVPQEQYVSQWQVAEEITPDGFATVDYDFKKPAASLDAQSSNP- 252
Cdd:TIGR03361 162 FEHTEDGHTLVLGDDASAHAPLPGA-SLPYN-PDSGGVADRPVISQWTYRRQVRPGQVALRDYDFKKPAASLEAQASADe 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  253 GAYEPGGLQVYEWLGGYTEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHPRPAENRQYLIAQAHYRIQ 332
Cdd:TIGR03361 240 QGHQAPDLEHYDYPGRFKDQERGKRLARVRLEALRADAKRAEGESNCRRLAPGYLFTLSGHPRAALNREYLVVSVHHHGR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  333 EGGYAS--GAEDAVFDIDFRVLPATVPFRVARATPVPRTHGPQTATVVGQAGEEIWTDEYGRVKVHFHWDRYGKKNENSS 410
Cdd:TIGR03361 320 QPQVLEesGGSGAGYRNSFQCIPATVPFRPPRRTPKPRIDGPQTATVVGPAGEEIYTDEYGRVKVQFHWDRYGKRDEKSS 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  411 CWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNASNMPPWDLPGNATQSGFLSRSKNGdRGTANALM 490
Cdd:TIGR03361 400 CWVRVAQPWAGNGWGSVAIPRVGQEVVVDFLEGDPDRPIVTGRVYNAENMPPYSLPANKTQSGFRSRSSKG-GGGFNELR 478

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 489904844  491 FEDSAGAERIWLHAERDMDCEVEANESHTVDGNRT 525
Cdd:TIGR03361 479 FEDKAGAEEIYLHAQRDMNTEVENDSTHTVGNNRT 513
5 super family cl33691
baseplate hub subunit and tail lysozyme; Provisional
 521-667 4.14e-13

baseplate hub subunit and tail lysozyme; Provisional


The actual alignment was detected with superfamily member PHA02596:

Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 72.87  E-value: 4.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 521 DGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETVNGVETRTVNGDWKETI 600
Cdd:PHA02596 428 DGTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYYNMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQV 507

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489904844 601 TGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQTGAHDITITGdqTSSITGAvSHTVTGA 667
Cdd:PHA02596 508 DGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFDMTVGGNWSEQMAG--MSSIASG-TYTIDGS 571
 
Name Accession Description Interval E-value
VI_Rhs_Vgr TIGR03361
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
 16-525 0e+00

type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.


Pssm-ID: 274542 [Multi-domain]  Cd Length: 513  Bit Score: 770.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   16 TPLPPQALQFRSMHGHEGLSALYEFEVDLLAATHTLELKSLLGKPVSLEIE-TGGAPRYLSGQATRCALVGregDSARQY 94
Cdd:TIGR03361   5 TPLGPDALQVLSFSGDEALSRLFSFRLELVSADPDIDLEDLLGQPATLTLGrDGGGPRYFHGIVTRFEQGG---TGRRLT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   95 VYRVTMRPWLWYLTQTSDSKIFQQMSVVDVLRQVLADYPF-PVEYRLAGSYRRWEYCVQYQETDFAFVSRLMEHEGIYYW 173
Cdd:TIGR03361  82 RYRLTLVPWLWLLTLRRDSRIFQNKSVPEIITEVLKEHGItDFRFRLSKSYPPREYCVQYRESDLDFVSRLLEEEGIFYY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  174 FRHESGRHTLVLTDDITQHDECPGAaQLPYYgPDRATVPQEQYVSQWQVAEEITPDGFATVDYDFKKPAASLDAQSSNP- 252
Cdd:TIGR03361 162 FEHTEDGHTLVLGDDASAHAPLPGA-SLPYN-PDSGGVADRPVISQWTYRRQVRPGQVALRDYDFKKPAASLEAQASADe 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  253 GAYEPGGLQVYEWLGGYTEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHPRPAENRQYLIAQAHYRIQ 332
Cdd:TIGR03361 240 QGHQAPDLEHYDYPGRFKDQERGKRLARVRLEALRADAKRAEGESNCRRLAPGYLFTLSGHPRAALNREYLVVSVHHHGR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  333 EGGYAS--GAEDAVFDIDFRVLPATVPFRVARATPVPRTHGPQTATVVGQAGEEIWTDEYGRVKVHFHWDRYGKKNENSS 410
Cdd:TIGR03361 320 QPQVLEesGGSGAGYRNSFQCIPATVPFRPPRRTPKPRIDGPQTATVVGPAGEEIYTDEYGRVKVQFHWDRYGKRDEKSS 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  411 CWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNASNMPPWDLPGNATQSGFLSRSKNGdRGTANALM 490
Cdd:TIGR03361 400 CWVRVAQPWAGNGWGSVAIPRVGQEVVVDFLEGDPDRPIVTGRVYNAENMPPYSLPANKTQSGFRSRSSKG-GGGFNELR 478

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 489904844  491 FEDSAGAERIWLHAERDMDCEVEANESHTVDGNRT 525
Cdd:TIGR03361 479 FEDKAGAEEIYLHAQRDMNTEVENDSTHTVGNNRT 513
VgrG COG3501
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
 5-737 0e+00

Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];


Pssm-ID: 442724 [Multi-domain]  Cd Length: 743  Bit Score: 759.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   5 LAMAERIVRALTPLPPQALQFRSMHGHEGLSALYEFEVDLLAATHTLELKSLLGKPVSLEIET-GGAPRYLSGQATRCAL 83
Cdd:COG3501    3 LSQSNRLLTLETPLGDDALLVLRFSGEEALSRPFEFELELLSEDADLDLDALLGKPATLTLRTaDGPERYFHGIVTEFEQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  84 VGREGDSARqyvYRVTMRPWLWYLTQTSDSKIFQQMSVVDVLRQVLADYPFP-VEYRLAGSYRRWEYCVQYQETDFAFVS 162
Cdd:COG3501   83 LGTDGGLAR---YRLTLVPWLWLLTLRRDSRIFQDKSVPDIVEEVLAEYGLAaFEFRLSGSYPPREYCVQYRESDLDFVS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 163 RLMEHEGIYYWFRHESGRHTLVLTDDITQHDECPGAAqLPYYGPDRATVPQEqYVSQWQVAEEITPDGFATVDYDFKKPA 242
Cdd:COG3501  160 RLLEEEGIYYYFEHEEGGHTLVLADDPSAHPPLPGAT-LPYHPRSGADEEED-SITRWRVRRRVRPGKVTLRDYDFKKPA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 243 ASLDAQSSNPGAYEPGGLQVYEWLGGYT-EPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHPRPAENRQ 321
Cdd:COG3501  238 ADLEASASSPRDGDEGDLEVYDYPGRYTaDPAEGERLARLRLEALRARAVRVEGESNVRGLAPGRRFTLTGHPRADLNGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 322 YLIAQAHYRIQEGGYA-SGAEDAVFDIDFRVLPATVPFRVARATPVPRTHGPQTATVVGQAGEEIWTDEYGRVKVHFHWD 400
Cdd:COG3501  318 YLVTSVTHEGSQNLYSgAGGEDGGYRNRFTAIPADVPFRPPRRTPKPRIAGPQTATVVGPAGEEIHTDEYGRVKVQFHWD 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 401 RYGKKNENSSCWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNASNMPPWDLPGNATQSGFLSRSKN 480
Cdd:COG3501  398 REGKKDENSSCWVRVAQPWAGAGWGGHFIPRVGQEVLVAFLDGDPDRPIVTGRVYNGANMPPYTLPANKTRSGIRTRSSP 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 481 GdrGTANALMFEDSAGAERIWLHAERDMDCEVEANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTV 560
Cdd:COG3501  478 G--GGFNELRFDDKAGQEEIFLHAEKDMNTLVDNDETITVGNDRTEEVGTDETGTVAGNQGLTVSGDQTVVVGGNQTLVV 555

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 561 TGEVSETTTGNETRTFNGDVTETVNGVETrTVNGDWKETITGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQ 640
Cdd:COG3501  556 GGARTLVVGGNLAAVVGGAAATAGGAQAT-LVAGALLLLAAGGALTTVGGGGTTTGGGAAATAGGGGAGAAAGGAATAAA 634

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 641 TGAHDIT-ITGDQTSSITGAVSHTVTGAYTQTVTDPVTVNANTSMTVVTPSWTVSSASQQAFWTANTLRGTPARLTVVGA 719
Cdd:COG3501  635 GAAATSAaGGASSAAAAAGGAAGAGGGGLAAAGGGGAAAAGGAGAGGAGGGAGALAAGAAAVAAAAAGGAGGGAAAGGII 714

                        730
                 ....*....|....*...
gi 489904844 720 AADFWGVRQQVYGGINSQ 737
Cdd:COG3501  715 GAGGTGIGGGGATAGGGA 732
Phage_GPD pfam05954
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
 33-334 6.73e-115

Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.


Pssm-ID: 428689  Cd Length: 302  Bit Score: 350.07  E-value: 6.73e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   33 GLSALYEFEVDLLAATHTLELKSLLGKPVSLEIET-GGAPRYLSGQATRCALVGREGDSARqyvYRVTMRPWLWYLTQTS 111
Cdd:pfam05954   1 GLSRLFEFELTLLSDDPDIDLKALLGQPVTVSIELdGGGPRYFHGIVTEFEQVGSDGRLTR---YRLTLVPWLWLLTLRR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  112 DSKIFQQMSVVDVLRQVLADYPFPV--EYRLAGSYRRWEYCVQYQETDFAFVSRLMEHEGIYYWFRHESGRHTLVLTDDI 189
Cdd:pfam05954  78 DSRIFQNKTVPDILEAVLGEHGIAVafRFRLTRSYPPREYCVQYRESDLAFVSRLLEEEGIFYFFEHAEGSHTLVLADDS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  190 TQHDECPGAAQLPYYGPDRATVPQEqYVSQWQVAEEITPDGFATVDYDFKKPAASLDAQSSNPGAYEPGGLQVYEWLGGY 269
Cdd:pfam05954 158 SALPPSAGGPSLPYHPPSGTEAEGD-HITRFTARRRLRPGTVTLRDYDYKKPRADLSAVAAAPQGAAGSAYEVYDYPGRY 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489904844  270 TEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHP-RPAENRQYLIAQAHYRIQEG 334
Cdd:pfam05954 237 DSSAEGERLARLRLEALRARARRFSGESNVRGLAPGRRFTLSGHPrRAAADREYLITRVEHTGSNN 302
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 521-667 4.14e-13

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 72.87  E-value: 4.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 521 DGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETVNGVETRTVNGDWKETI 600
Cdd:PHA02596 428 DGTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYYNMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQV 507

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489904844 601 TGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQTGAHDITITGdqTSSITGAvSHTVTGA 667
Cdd:PHA02596 508 DGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFDMTVGGNWSEQMAG--MSSIASG-TYTIDGS 571
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 519-718 1.59e-04

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 45.32  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 519 TVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETV--NGVETRTVNGDW 596
Cdd:COG3468  221 AGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTGGGGGGTGTGSGGGGGGGANGGGSGggGGASGTGGGGTA 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 597 KETITGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQTGAHDITITGDQTSSITGAVSHTVTGAYTQTVTDPV 676
Cdd:COG3468  301 STGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTGAALAGTGGSGSGGGGGGGSGGGGGAG 380

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489904844 677 TVNANTSMTVVTPSWTVSSASQQAFWTAN-----TLRGTPARLTVVG 718
Cdd:COG3468  381 GGGANTGSDGVGTGLTTGGTGNNGGGGVGgggggGLTLTGGTLTVNG 427
Gp5_C pfam06715
Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the ...
 514-537 7.75e-04

Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5. This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerize to form a beta solenoid type structure. This family also includes repeats from bacterial Vgr proteins.


Pssm-ID: 310962 [Multi-domain]  Cd Length: 24  Bit Score: 37.26  E-value: 7.75e-04
                          10        20
                  ....*....|....*....|....
gi 489904844  514 ANESHTVDGNRTTLIGGNDTLTVR 537
Cdd:pfam06715   1 GNETETVGGNRTVTVGGNETETVG 24
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 518-653 6.03e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 39.29  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 518 HTVDGNRTTLIGGNDTLTvRGTRTTTIDGldtETFNAGATRTVTGEvsETTTGNETRTFNGDvtETVNGVETRTVNGDwk 597
Cdd:cd21575   16 QTLYGGQMTTPSGDQTLY-GGQMTTSFSE---QTLYGGQMTTPSGD--QTLYGGQMTTPNGN--QTLYGGQMTTSTGN-- 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 598 ETITGEMTETRTGDetRTVTGAVTETITGDVT----QTITGAVTQTQTGAHDITITGDQT 653
Cdd:cd21575   86 QTLYGGQMTTSGSD--QTLYGGQMTTSSGDQTlyggQMTTSSGDQTLYGGQMTTSTGDQT 143
holdfast_HfaD NF037936
holdfast anchor protein HfaD;
546-721 8.88e-03

holdfast anchor protein HfaD;


Pssm-ID: 468280 [Multi-domain]  Cd Length: 373  Bit Score: 39.01  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 546 GLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETV----NGVETRTVNGdwkeTITGEMTETRTGDETRTvtgAVT 621
Cdd:NF037936  37 GVDDADASLTSNQTMSGAVTAHTTLTVNGTGGGSSAVATtargNYLSTTASQG----TIDADAVQVNTGDVTAR---TQV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 622 ETITGdvtQTITGAVTQTqTGAHDITITGDQTSSITGAVSHTVT-------GAYTQTVTDPVTVNANTSMTVVTPSWTVS 694
Cdd:NF037936 110 EAPTA---RALDGGASSA-AAIGNTVALGLPNGSLTARADQSSQadvlaevGADVQYSPAPANFNATAVANAYQASSTNS 185

                        170       180
                 ....*....|....*....|....*..
gi 489904844 695 SASQQAFWTANTLRGTPARLTVVGAAA 721
Cdd:NF037936 186 SAQDLIVRQTNAAATVTARTFVYYGNG 212
 
Name Accession Description Interval E-value
VI_Rhs_Vgr TIGR03361
type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs ...
 16-525 0e+00

type VI secretion system Vgr family protein; Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.


Pssm-ID: 274542 [Multi-domain]  Cd Length: 513  Bit Score: 770.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   16 TPLPPQALQFRSMHGHEGLSALYEFEVDLLAATHTLELKSLLGKPVSLEIE-TGGAPRYLSGQATRCALVGregDSARQY 94
Cdd:TIGR03361   5 TPLGPDALQVLSFSGDEALSRLFSFRLELVSADPDIDLEDLLGQPATLTLGrDGGGPRYFHGIVTRFEQGG---TGRRLT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   95 VYRVTMRPWLWYLTQTSDSKIFQQMSVVDVLRQVLADYPF-PVEYRLAGSYRRWEYCVQYQETDFAFVSRLMEHEGIYYW 173
Cdd:TIGR03361  82 RYRLTLVPWLWLLTLRRDSRIFQNKSVPEIITEVLKEHGItDFRFRLSKSYPPREYCVQYRESDLDFVSRLLEEEGIFYY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  174 FRHESGRHTLVLTDDITQHDECPGAaQLPYYgPDRATVPQEQYVSQWQVAEEITPDGFATVDYDFKKPAASLDAQSSNP- 252
Cdd:TIGR03361 162 FEHTEDGHTLVLGDDASAHAPLPGA-SLPYN-PDSGGVADRPVISQWTYRRQVRPGQVALRDYDFKKPAASLEAQASADe 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  253 GAYEPGGLQVYEWLGGYTEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHPRPAENRQYLIAQAHYRIQ 332
Cdd:TIGR03361 240 QGHQAPDLEHYDYPGRFKDQERGKRLARVRLEALRADAKRAEGESNCRRLAPGYLFTLSGHPRAALNREYLVVSVHHHGR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  333 EGGYAS--GAEDAVFDIDFRVLPATVPFRVARATPVPRTHGPQTATVVGQAGEEIWTDEYGRVKVHFHWDRYGKKNENSS 410
Cdd:TIGR03361 320 QPQVLEesGGSGAGYRNSFQCIPATVPFRPPRRTPKPRIDGPQTATVVGPAGEEIYTDEYGRVKVQFHWDRYGKRDEKSS 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  411 CWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNASNMPPWDLPGNATQSGFLSRSKNGdRGTANALM 490
Cdd:TIGR03361 400 CWVRVAQPWAGNGWGSVAIPRVGQEVVVDFLEGDPDRPIVTGRVYNAENMPPYSLPANKTQSGFRSRSSKG-GGGFNELR 478

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 489904844  491 FEDSAGAERIWLHAERDMDCEVEANESHTVDGNRT 525
Cdd:TIGR03361 479 FEDKAGAEEIYLHAQRDMNTEVENDSTHTVGNNRT 513
VgrG COG3501
Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly ...
 5-737 0e+00

Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly [Intracellular trafficking, secretion, and vesicular transport, Mobilome: prophages, transposons, General function prediction only];


Pssm-ID: 442724 [Multi-domain]  Cd Length: 743  Bit Score: 759.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   5 LAMAERIVRALTPLPPQALQFRSMHGHEGLSALYEFEVDLLAATHTLELKSLLGKPVSLEIET-GGAPRYLSGQATRCAL 83
Cdd:COG3501    3 LSQSNRLLTLETPLGDDALLVLRFSGEEALSRPFEFELELLSEDADLDLDALLGKPATLTLRTaDGPERYFHGIVTEFEQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  84 VGREGDSARqyvYRVTMRPWLWYLTQTSDSKIFQQMSVVDVLRQVLADYPFP-VEYRLAGSYRRWEYCVQYQETDFAFVS 162
Cdd:COG3501   83 LGTDGGLAR---YRLTLVPWLWLLTLRRDSRIFQDKSVPDIVEEVLAEYGLAaFEFRLSGSYPPREYCVQYRESDLDFVS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 163 RLMEHEGIYYWFRHESGRHTLVLTDDITQHDECPGAAqLPYYGPDRATVPQEqYVSQWQVAEEITPDGFATVDYDFKKPA 242
Cdd:COG3501  160 RLLEEEGIYYYFEHEEGGHTLVLADDPSAHPPLPGAT-LPYHPRSGADEEED-SITRWRVRRRVRPGKVTLRDYDFKKPA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 243 ASLDAQSSNPGAYEPGGLQVYEWLGGYT-EPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHPRPAENRQ 321
Cdd:COG3501  238 ADLEASASSPRDGDEGDLEVYDYPGRYTaDPAEGERLARLRLEALRARAVRVEGESNVRGLAPGRRFTLTGHPRADLNGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 322 YLIAQAHYRIQEGGYA-SGAEDAVFDIDFRVLPATVPFRVARATPVPRTHGPQTATVVGQAGEEIWTDEYGRVKVHFHWD 400
Cdd:COG3501  318 YLVTSVTHEGSQNLYSgAGGEDGGYRNRFTAIPADVPFRPPRRTPKPRIAGPQTATVVGPAGEEIHTDEYGRVKVQFHWD 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 401 RYGKKNENSSCWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNASNMPPWDLPGNATQSGFLSRSKN 480
Cdd:COG3501  398 REGKKDENSSCWVRVAQPWAGAGWGGHFIPRVGQEVLVAFLDGDPDRPIVTGRVYNGANMPPYTLPANKTRSGIRTRSSP 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 481 GdrGTANALMFEDSAGAERIWLHAERDMDCEVEANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTV 560
Cdd:COG3501  478 G--GGFNELRFDDKAGQEEIFLHAEKDMNTLVDNDETITVGNDRTEEVGTDETGTVAGNQGLTVSGDQTVVVGGNQTLVV 555

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 561 TGEVSETTTGNETRTFNGDVTETVNGVETrTVNGDWKETITGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQ 640
Cdd:COG3501  556 GGARTLVVGGNLAAVVGGAAATAGGAQAT-LVAGALLLLAAGGALTTVGGGGTTTGGGAAATAGGGGAGAAAGGAATAAA 634

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 641 TGAHDIT-ITGDQTSSITGAVSHTVTGAYTQTVTDPVTVNANTSMTVVTPSWTVSSASQQAFWTANTLRGTPARLTVVGA 719
Cdd:COG3501  635 GAAATSAaGGASSAAAAAGGAAGAGGGGLAAAGGGGAAAAGGAGAGGAGGGAGALAAGAAAVAAAAAGGAGGGAAAGGII 714

                        730
                 ....*....|....*...
gi 489904844 720 AADFWGVRQQVYGGINSQ 737
Cdd:COG3501  715 GAGGTGIGGGGATAGGGA 732
vgr_GE TIGR01646
Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with ...
 27-507 2.09e-162

Rhs element Vgr protein; This model represents the Vgr family of proteins, associated with some classes of Rhs elements. This model does not include a large octapeptide repeat region, VGXXXXXX, found in the Vgr of Rhs classes G and E.


Pssm-ID: 273730 [Multi-domain]  Cd Length: 483  Bit Score: 479.28  E-value: 2.09e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   27 SMHGHEGLSALYEFEVDLLAATHTLELKSLLGKPVSLEIETGGAP---RYLSGQATRCALVGREGDSARqyvYRVTMRPW 103
Cdd:TIGR01646   5 SFEGNEILSQPFTYELILRSADADLDLAAMLGKDASLSLELPDAAstqRIFTGVIAGFSLGSTANGDAR---YSLVLRPW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  104 LWYLTQTSDSKIFQQMSVVDVLRQVLADYPFP-VEYRLAGSYRRWEYCVQYQETDFAFVSRLMEHEGIYYWFRHESGRHT 182
Cdd:TIGR01646  82 LWLLTRRRNNRIFQDTSVPDIIEEILREYGFAdFRFDVAREYPQREYCVQYGETDFDFILRLLEEEGIIYYFEHDPKKHI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  183 LVLTDDITQHDECPGAAQLPYYGPDrATVPQEQYVSQWQVAEEITPDGFATVDYDFKKPAASLDAQSSNPGAYEPG-GLQ 261
Cdd:TIGR01646 162 LVAPDTSGQPQITLGYASLPFELPG-AMDAREQSIYDWTRAQQVNSASVALVDYDFKNPTARLQAQSNISRQQAQVpDLE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  262 VYEWLGGYTEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHPRPAENRQYLIAQAHYRIQEGGYASGAE 341
Cdd:TIGR01646 241 AYDYAGSYLDAQHGELYARLRLEALQSRAAKIQGEGNAAGLAPGQLFVLSGHPRNDQNNGYLIVSAIHSIVQLGWDTGIQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  342 DAVFDIDFRVLPATVPFRvARATPVPRTHGPQTATVVGQAGEEIWTDEYGRVKVHFHWDRYGKKNENSSCWVRVSSPWAG 421
Cdd:TIGR01646 321 GYELPNQFIAIEVDVIWR-PAATPLPKVNGPQIAVVVGAQGEEIHTDKYGRIRVHFHWDRYGQSNDYSSCWIRVAQPWAG 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  422 GGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNASNMPPWDLPGNATQSGFLSRSKNGdrGTANALMFEDSAGAERIW 501
Cdd:TIGR01646 400 KNWGSLAIPRVGQEVIVGFLDGDPDRPIVTGRVYNAANPPPYRLPAHNTQSGFKSRTLRG--GSQNQLRFDDDKGKEQLQ 477


                  ....*.
gi 489904844  502 LHAERD 507
Cdd:TIGR01646 478 LHAERD 483
Phage_GPD pfam05954
Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D ...
 33-334 6.73e-115

Phage tail baseplate hub (GPD); This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.


Pssm-ID: 428689  Cd Length: 302  Bit Score: 350.07  E-value: 6.73e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844   33 GLSALYEFEVDLLAATHTLELKSLLGKPVSLEIET-GGAPRYLSGQATRCALVGREGDSARqyvYRVTMRPWLWYLTQTS 111
Cdd:pfam05954   1 GLSRLFEFELTLLSDDPDIDLKALLGQPVTVSIELdGGGPRYFHGIVTEFEQVGSDGRLTR---YRLTLVPWLWLLTLRR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  112 DSKIFQQMSVVDVLRQVLADYPFPV--EYRLAGSYRRWEYCVQYQETDFAFVSRLMEHEGIYYWFRHESGRHTLVLTDDI 189
Cdd:pfam05954  78 DSRIFQNKTVPDILEAVLGEHGIAVafRFRLTRSYPPREYCVQYRESDLAFVSRLLEEEGIFYFFEHAEGSHTLVLADDS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  190 TQHDECPGAAQLPYYGPDRATVPQEqYVSQWQVAEEITPDGFATVDYDFKKPAASLDAQSSNPGAYEPGGLQVYEWLGGY 269
Cdd:pfam05954 158 SALPPSAGGPSLPYHPPSGTEAEGD-HITRFTARRRLRPGTVTLRDYDYKKPRADLSAVAAAPQGAAGSAYEVYDYPGRY 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489904844  270 TEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPGYLFTLRNHP-RPAENRQYLIAQAHYRIQEG 334
Cdd:pfam05954 237 DSSAEGERLARLRLEALRARARRFSGESNVRGLAPGRRFTLSGHPrRAAADREYLITRVEHTGSNN 302
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 521-667 4.14e-13

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 72.87  E-value: 4.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 521 DGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETVNGVETRTVNGDWKETI 600
Cdd:PHA02596 428 DGTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYYNMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQV 507

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489904844 601 TGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQTGAHDITITGdqTSSITGAvSHTVTGA 667
Cdd:PHA02596 508 DGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFDMTVGGNWSEQMAG--MSSIASG-TYTIDGS 571
COG4253 COG4253
Uncharacterized conserved protein, DUF2345 family [Function unknown];
71-499 1.89e-12

Uncharacterized conserved protein, DUF2345 family [Function unknown];


Pssm-ID: 443395 [Multi-domain]  Cd Length: 900  Bit Score: 71.23  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  71 PRYLSGQATRCALVGREGDSARQYVYRVtmrPWLWYLTQTSDSKIFQQMSVVDVLRQVLADYPFPVEYRLAGSYRRWEYC 150
Cdd:COG4253  126 RRQLSALALALVLAVLSRLQAFSRRALD---ELLALLLLRLRRRRALLRLRLADAALVRSTVEELLSRRHGDEVAFADDR 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 151 VQYQETDFAFVSRLMEHEGIYYWFRHESGRHTLVLTDDITQHDECPGAAQLPYYGPDRATVPQEQYVSQWQVAEEIT--- 227
Cdd:COG4253  203 LTERRASAEAASRADAAALRDLRLALRLARRAATAADDAQTTDDARLTADDSAADAGSLSGSGGDGGAAGGSLAEATssl 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 228 --PDGFATVDYDFKKPAASLDAQSSNPGAYEPGGLQVYEWLGGYTEPDQGERYSRIRLEALQAHGESVTGACNVRAFAPG 305
Cdd:COG4253  283 rvPAASVSLARYQRARRAAAAAAAADARAGGADAAGGVGTGGGRRLAAGLAGAAAEEEEAVGAEARARRRRLLRAARAAI 362

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 306 YLFTLRNHPRPAENRQYLIAQAHYRIQEGG-------YASGAEDAVFDIDFRVLPATVPFRVARATPVPRTHGPQTATVV 378
Cdd:COG4253  363 RLLAAAALALLALGRGALAGRSPAAAAGPGivggtdrRARRRATAFVDRAAGPPPRTQRARRPLLPRPRGAGGPPPRVVS 442

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 379 GQAGEEIWTDEYGRVKVHFHWDRYGKKNENSSCWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVYNAS 458
Cdd:COG4253  443 TRAGDTPSADDDDGGRRVVRDDRRVAWVGGGESWGAGGGAGAGGGVGGGVVPLLGDGDVVIAAEGGGPPAPGGGAPAAHS 522

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 489904844 459 NmPPWDLPGNATQSGFLSRSKNGDRGTANALMFEDSAGAER 499
Cdd:COG4253  523 A-AHLDHSSGALSGGNSRNTGGNGLNLLDDDDDEGQQRSAT 562
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 538-696 4.84e-12

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 69.40  E-value: 4.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 538 GTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETVNGVETRTVNGDwketitgemtetrtgdETRTVT 617
Cdd:PHA02596 429 GTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYYNMGNVLQTIDGNVTIFVRGN----------------VTKTVE 492

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489904844 618 GAVTETITGDVTQTITGAVTQTQTGAHDITITGDQTSSITGAVSHTVTGAYTqtvtdpVTVNANTSMTVVTpSWTVSSA 696
Cdd:PHA02596 493 GNGTLYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFD------MTVGGNWSEQMAG-MSSIASG 564
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 512-650 9.59e-12

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 68.24  E-value: 9.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 512 VEANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTEtfnagatrTVTGEVSETTTGNETRTFNGDVTETVNGVETRT 591
Cdd:PHA02596 443 VKQDRNVNVKGNLKVVVEGDAIYYNMGNVLQTIDGNVTI--------FVRGNVTKTVEGNGTLYVKGNVTVQVDGNLDAT 514

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489904844 592 VNGDWKETITGEMTETRTGDETRTVTGAVTETITGDVTQTITGA--VTQTQTgahdiTITG 650
Cdd:PHA02596 515 VKGNATTLVEGNQTNTVNGNYKLKVEGNFDMTVGGNWSEQMAGMssIASGTY-----TIDG 570
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 505-602 1.29e-10

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 64.78  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 505 ERDMDCEVEANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETV 584
Cdd:PHA02596 460 EGDAIYYNMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVNGNYKLKV 539

                         90
                 ....*....|....*...
gi 489904844 585 NGVETRTVNGDWKETITG 602
Cdd:PHA02596 540 EGNFDMTVGGNWSEQMAG 557
Phage_base_V pfam04717
Type VI secretion system/phage-baseplate injector OB domain; Family of bacterial and phage ...
 391-455 6.88e-10

Type VI secretion system/phage-baseplate injector OB domain; Family of bacterial and phage baseplate assembly proteins responsible for forming the small spike at the end of the tail or bacterial pathogenic needle-shaft. This entry represents the OB fold part of the structure. This structure contains an unusual extra beta hairpin that forms the foundation of the spike protein's beta helix.


Pssm-ID: 428084 [Multi-domain]  Cd Length: 75  Bit Score: 55.66  E-value: 6.88e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489904844  391 GRVKVHFHWdRYGkknENSSCWVRVSSPWAGGGFGGIQLPRVGDEVIVDFIGGYPDRPIVIGRVY 455
Cdd:pfam04717  15 GRVKVGVPW-LTD---EEESGWARWAAPRAGAGRGLWFLPEVGEQVLVLFEGGDPSRPVVLGGLW 75
34 PHA02584
long tail fiber, proximal subunit; Provisional
 504-685 3.29e-05

long tail fiber, proximal subunit; Provisional


Pssm-ID: 222890 [Multi-domain]  Cd Length: 1229  Bit Score: 47.83  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  504 AERDMDCEVEANESHT----VDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGD 579
Cdd:PHA02584  899 IRRDIDQTVNGSLTFTkntnLSAPLVSSSTATFGGSVTANSTLTTQNTSNGTVVVVDETSIAFYSQNNTTGNIVFNIDGT 978

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844  580 VTeTVNGVETRTVNGDWKETITGEMTETRtgdETRTVTGAVTETITGDVTQTITGAVTQTQTGAhditiTGDQTSSITGA 659
Cdd:PHA02584  979 VD-PINVNANGTLNATGVATNGRAVYAEG---GGIARTNNAARAITGGFTIRNDGSTTVFLLTA-----AGDQTGGFNGL 1049

                         170       180
                  ....*....|....*....|....*...
gi 489904844  660 VSHTVTGAYTQTVTDPVTVNAN--TSMT 685
Cdd:PHA02584 1050 KSLIINNANGQVTINDNYIINAggTIMS 1077
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 519-718 1.59e-04

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 45.32  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 519 TVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETV--NGVETRTVNGDW 596
Cdd:COG3468  221 AGGATGGAGSGGNTGGGVGGGGGSAGGTGGGGLTGGGAAGTGGGGGGTGTGSGGGGGGGANGGGSGggGGASGTGGGGTA 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 597 KETITGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQTGAHDITITGDQTSSITGAVSHTVTGAYTQTVTDPV 676
Cdd:COG3468  301 STGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTGAALAGTGGSGSGGGGGGGSGGGGGAG 380

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489904844 677 TVNANTSMTVVTPSWTVSSASQQAFWTAN-----TLRGTPARLTVVG 718
Cdd:COG3468  381 GGGANTGSDGVGTGLTTGGTGNNGGGGVGgggggGLTLTGGTLTVNG 427
Gp5_C pfam06715
Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the ...
 514-537 7.75e-04

Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5. This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerize to form a beta solenoid type structure. This family also includes repeats from bacterial Vgr proteins.


Pssm-ID: 310962 [Multi-domain]  Cd Length: 24  Bit Score: 37.26  E-value: 7.75e-04
                          10        20
                  ....*....|....*....|....
gi 489904844  514 ANESHTVDGNRTTLIGGNDTLTVR 537
Cdd:pfam06715   1 GNETETVGGNRTVTVGGNETETVG 24
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 502-571 2.93e-03

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 40.89  E-value: 2.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 502 LHAERDMDCEVEANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDGldteTFNAgatrTVTGEVSETTTGN 571
Cdd:PHA02596 497 LYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEG----NFDM----TVGGNWSEQMAGM 558
Gp5_C pfam06715
Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the ...
 578-600 3.31e-03

Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5. This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerize to form a beta solenoid type structure. This family also includes repeats from bacterial Vgr proteins.


Pssm-ID: 310962 [Multi-domain]  Cd Length: 24  Bit Score: 35.34  E-value: 3.31e-03
                          10        20
                  ....*....|....*....|...
gi 489904844  578 GDVTETVNGVETRTVNGDWKETI 600
Cdd:pfam06715   1 GNETETVGGNRTVTVGGNETETV 23
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 505-602 3.51e-03

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 40.89  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 505 ERDMDCEVEANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDgldtetfnagatrtvtgevsetttGNETRTFNGDVTETV 584
Cdd:PHA02596 492 EGNGTLYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVN------------------------GNYKLKVEGNFDMTV 547

                         90       100
                 ....*....|....*....|...
gi 489904844 585 NGVETRTVNGDWKE-----TITG 602
Cdd:PHA02596 548 GGNWSEQMAGMSSIasgtyTIDG 570
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 514-683 4.72e-03

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 40.70  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 514 ANESHTVDGNRTTLIGGNDTLTVRGTRTTTIDGLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETVNGVETRTVN 593
Cdd:COG3468  275 GGGGGANGGGSGGGGGASGTGGGGTASTGGGGGGGGGNGGGGGGGSNAGGGSGGGGGGGGGGGGGGTTLNGAGSAGGGTG 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 594 GDWKETITGEMTETRTGDETRTVTGAVTETITGDVTQTITGAVTQTQTGAHDITITGDQTSSITGAVSHTVTGAYT---- 669
Cdd:COG3468  355 AALAGTGGSGSGGGGGGGSGGGGGAGGGGANTGSDGVGTGLTTGGTGNNGGGGVGGGGGGGLTLTGGTLTVNGNYTgnng 434

                        170       180
                 ....*....|....*....|....*
gi 489904844 670 -----------QTVTDPVTVNANTS 683
Cdd:COG3468  435 tlvlntvlgddNSPTDRLVVNGNTS 459
Gp5_C pfam06715
Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the ...
 530-551 5.68e-03

Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5. This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerize to form a beta solenoid type structure. This family also includes repeats from bacterial Vgr proteins.


Pssm-ID: 310962 [Multi-domain]  Cd Length: 24  Bit Score: 34.95  E-value: 5.68e-03
                          10        20
                  ....*....|....*....|..
gi 489904844  530 GNDTLTVRGTRTTTIDGLDTET 551
Cdd:pfam06715   1 GNETETVGGNRTVTVGGNETET 22
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
 518-653 6.03e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 39.29  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 518 HTVDGNRTTLIGGNDTLTvRGTRTTTIDGldtETFNAGATRTVTGEvsETTTGNETRTFNGDvtETVNGVETRTVNGDwk 597
Cdd:cd21575   16 QTLYGGQMTTPSGDQTLY-GGQMTTSFSE---QTLYGGQMTTPSGD--QTLYGGQMTTPNGN--QTLYGGQMTTSTGN-- 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 598 ETITGEMTETRTGDetRTVTGAVTETITGDVT----QTITGAVTQTQTGAHDITITGDQT 653
Cdd:cd21575   86 QTLYGGQMTTSGSD--QTLYGGQMTTSSGDQTlyggQMTTSSGDQTLYGGQMTTSTGDQT 143
holdfast_HfaD NF037936
holdfast anchor protein HfaD;
546-721 8.88e-03

holdfast anchor protein HfaD;


Pssm-ID: 468280 [Multi-domain]  Cd Length: 373  Bit Score: 39.01  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 546 GLDTETFNAGATRTVTGEVSETTTGNETRTFNGDVTETV----NGVETRTVNGdwkeTITGEMTETRTGDETRTvtgAVT 621
Cdd:NF037936  37 GVDDADASLTSNQTMSGAVTAHTTLTVNGTGGGSSAVATtargNYLSTTASQG----TIDADAVQVNTGDVTAR---TQV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489904844 622 ETITGdvtQTITGAVTQTqTGAHDITITGDQTSSITGAVSHTVT-------GAYTQTVTDPVTVNANTSMTVVTPSWTVS 694
Cdd:NF037936 110 EAPTA---RALDGGASSA-AAIGNTVALGLPNGSLTARADQSSQadvlaevGADVQYSPAPANFNATAVANAYQASSTNS 185

                        170       180
                 ....*....|....*....|....*..
gi 489904844 695 SASQQAFWTANTLRGTPARLTVVGAAA 721
Cdd:NF037936 186 SAQDLIVRQTNAAATVTARTFVYYGNG 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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