NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489911472|ref|WP_003814883|]
View 

MULTISPECIES: iron-sulfur cluster insertion protein ErpA [Bordetella]

Protein Classification

iron-sulfur cluster insertion protein ErpA( domain architecture ID 10014301)

iron-sulfur cluster insertion protein ErpA is essential for growth and may play a role in isoprenoid biosynthesis

CATH:  2.60.300.12
Gene Ontology:  GO:0005506|GO:0016226|GO:0051537
SCOP:  4003950

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 11-123 5.44e-83

iron-sulfur cluster insertion protein ErpA; Provisional


:

Pssm-ID: 184186  Cd Length: 115  Bit Score: 237.90  E-value: 5.44e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  11 QAPPPVPLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVG 90
Cdd:PRK13623   3 SDDVPLPLVFTDAAAAKVKELIEEEGNPDLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVG 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489911472  91 AEIDYKEDLEGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:PRK13623  83 AEVDYTEGLEGSRFVIKNPNAKTTCGCGSSFSI 115
 
Name Accession Description Interval E-value
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 11-123 5.44e-83

iron-sulfur cluster insertion protein ErpA; Provisional


Pssm-ID: 184186  Cd Length: 115  Bit Score: 237.90  E-value: 5.44e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  11 QAPPPVPLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVG 90
Cdd:PRK13623   3 SDDVPLPLVFTDAAAAKVKELIEEEGNPDLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVG 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489911472  91 AEIDYKEDLEGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:PRK13623  83 AEVDYTEGLEGSRFVIKNPNAKTTCGCGSSFSI 115
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 17-123 2.12e-63

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 188.05  E-value: 2.12e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  17 PLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYK 96
Cdd:COG0316    1 PITLTDAAAKRIKRLLAKEGNPGLGLRVGVKGGGCSGFSYGLDFDDEPNEDDLVFEQDGVKVVVDPKSLPYLDGTEIDYV 80

                         90       100
                 ....*....|....*....|....*..
gi 489911472  97 EDLEGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:COG0316   81 EELLGSGFKFNNPNAKSSCGCGESFSV 107
TIGR00049 TIGR00049
Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be ...
 20-123 4.39e-54

Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272875 [Multi-domain]  Cd Length: 105  Bit Score: 164.68  E-value: 4.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   20 FTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYKEDL 99
Cdd:TIGR00049   2 LTDSAAKRIKALLAGEGEPNLGLRVGVKGGGCSGLQYGLEFDDEPNEDDEVFEQDGVKVVVDPKSLPYLDGSEIDYVEEL 81

                          90       100
                  ....*....|....*....|....
gi 489911472  100 EGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:TIGR00049  82 LGSGFTFTNPNAKGTCGCGKSFSV 105
Fe-S_biosyn pfam01521
Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster ...
 20-118 1.50e-19

Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.


Pssm-ID: 426304  Cd Length: 111  Bit Score: 77.30  E-value: 1.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   20 FTDSAAAKVKDLLAEEGNPelkLRVFVQGGG-------CS-GFQYGFTF-DEVVNDDDTVLDKAGVQLLVDPMSFQYLV- 89
Cdd:pfam01521   5 ITDAAAERLKKLLAGDKKE---LRLDVDDGGgpyskggCSiGGKFSLVLvDEPDPDYDEVIESNGGPIYVDSYSLPFLDe 81

                          90       100
                  ....*....|....*....|....*....
gi 489911472   90 GAEIDYKEDLEGAQFVIRNPNASTTCGCG 118
Cdd:pfam01521  82 GLTLDFVEDLGTLGLKSDNGNLDGNVGCG 110
IscA_HesB_Se NF038090
IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, ...
 21-119 5.93e-06

IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, are homologous to proteins of iron-sulfur cluster biosynthesis such as IscA, and belong to the broader set of HesB-related proteins.


Pssm-ID: 411672  Cd Length: 99  Bit Score: 41.93  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  21 TDSAAAKVKDLLAEEgNPELKLRVFVQGGGCSGFQYGFTFDEvVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYKEDLE 100
Cdd:NF038090   5 TDLASRKLKEYFADK-KIDSPIRVFLNQGGUAGPSLGLALDE-PKENDEVFEQDGLTFVIDKELLEQCGPIKVDFIDCRS 82

                         90
                 ....*....|....*....
gi 489911472 101 GaqFVIRNPNASTTCGCGS 119
Cdd:NF038090  83 G--FSITSSMPLGGGGCGS 99
 
Name Accession Description Interval E-value
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 11-123 5.44e-83

iron-sulfur cluster insertion protein ErpA; Provisional


Pssm-ID: 184186  Cd Length: 115  Bit Score: 237.90  E-value: 5.44e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  11 QAPPPVPLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVG 90
Cdd:PRK13623   3 SDDVPLPLVFTDAAAAKVKELIEEEGNPDLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVG 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489911472  91 AEIDYKEDLEGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:PRK13623  83 AEVDYTEGLEGSRFVIKNPNAKTTCGCGSSFSI 115
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 17-123 2.12e-63

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 188.05  E-value: 2.12e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  17 PLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYK 96
Cdd:COG0316    1 PITLTDAAAKRIKRLLAKEGNPGLGLRVGVKGGGCSGFSYGLDFDDEPNEDDLVFEQDGVKVVVDPKSLPYLDGTEIDYV 80

                         90       100
                 ....*....|....*....|....*..
gi 489911472  97 EDLEGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:COG0316   81 EELLGSGFKFNNPNAKSSCGCGESFSV 107
TIGR00049 TIGR00049
Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be ...
 20-123 4.39e-54

Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272875 [Multi-domain]  Cd Length: 105  Bit Score: 164.68  E-value: 4.39e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   20 FTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYKEDL 99
Cdd:TIGR00049   2 LTDSAAKRIKALLAGEGEPNLGLRVGVKGGGCSGLQYGLEFDDEPNEDDEVFEQDGVKVVVDPKSLPYLDGSEIDYVEEL 81

                          90       100
                  ....*....|....*....|....
gi 489911472  100 EGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:TIGR00049  82 LGSGFTFTNPNAKGTCGCGKSFSV 105
PLN03082 PLN03082
Iron-sulfur cluster assembly; Provisional
 2-123 8.54e-30

Iron-sulfur cluster assembly; Provisional


Pssm-ID: 215564  Cd Length: 163  Bit Score: 105.01  E-value: 8.54e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   2 NAVTETVDLQAPPPVP-----LVFTDSAAAKVKDLLAEEGNPELK-LRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAG 75
Cdd:PLN03082  34 SALKEASTSSSSPSSSasldaVHMTDNCIRRLKELQTSEPSAEDKmLRLSVETGGCSGFQYVFELDDKTNSDDRVFEKDG 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 489911472  76 VQLLVDPMSFQYLVGAEIDYKEDLEGAQFVIR-NPNASTTCGCGSSFSV 123
Cdd:PLN03082 114 VKLVVDNISYDFVKGATVDYVEELIRSAFVVStNPSAVGGCSCKSSFMV 162
IscA TIGR02011
iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC ...
 18-123 1.10e-23

iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin. IscA previously was believed to act as a scaffold and now is seen as an iron donor protein. This clade is limited to the proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 213674  Cd Length: 105  Bit Score: 87.57  E-value: 1.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   18 LVFTDSAAAKVKDLLAEEGNPeLKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDY-K 96
Cdd:TIGR02011   1 ITLTDSAAARVNTFLANRGKG-FGLRLGVKTSGCSGMAYVLEFVDEPTPDDIVFEDKGVKIVIDGKSLQYLDGTQLDFvK 79

                          90       100
                  ....*....|....*....|....*...
gi 489911472   97 EDL-EGAQFviRNPNASTTCGCGSSFSV 123
Cdd:TIGR02011  80 EGLnEGFKF--TNPNVKDECGCGESFHV 105
iscA PRK09502
iron-sulfur cluster assembly protein IscA;
18-123 1.78e-22

iron-sulfur cluster assembly protein IscA;


Pssm-ID: 181914 [Multi-domain]  Cd Length: 107  Bit Score: 84.54  E-value: 1.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  18 LVFTDSAAAKVKDLLAEEGNpELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDY-K 96
Cdd:PRK09502   3 ITLSDSAAARVNTFLANRGK-GFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFvK 81

                         90       100
                 ....*....|....*....|....*...
gi 489911472  97 EDL-EGAQFviRNPNASTTCGCGSSFSV 123
Cdd:PRK09502  82 EGLnEGFKF--TNPNVKDECGCGESFHV 107
sufA_proteo TIGR01997
FeS assembly scaffold SufA; This model represents the SufA protein of the SUF system of ...
 18-123 2.19e-20

FeS assembly scaffold SufA; This model represents the SufA protein of the SUF system of iron-sulfur cluster biosynthesis. This system performs FeS biosynthesis even during oxidative stress and tends to be absent in obligate anaerobic and microaerophilic bacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131052  Cd Length: 107  Bit Score: 79.10  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   18 LVFTDSAAAKVKDLLAEEGNpELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDY-K 96
Cdd:TIGR01997   3 ITLTDAAAIHIRELVAKRPE-AVGIRLGVKKTGCAGMEYVLDLVSEPKKDDDLIEHDGAKVFVAPEAVLFILGTQVDFvR 81

                          90       100
                  ....*....|....*....|....*..
gi 489911472   97 EDLeGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:TIGR01997  82 TTL-RQGFKFNNPNATSACGCGESFEL 107
Fe-S_biosyn pfam01521
Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster ...
 20-118 1.50e-19

Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.


Pssm-ID: 426304  Cd Length: 111  Bit Score: 77.30  E-value: 1.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472   20 FTDSAAAKVKDLLAEEGNPelkLRVFVQGGG-------CS-GFQYGFTF-DEVVNDDDTVLDKAGVQLLVDPMSFQYLV- 89
Cdd:pfam01521   5 ITDAAAERLKKLLAGDKKE---LRLDVDDGGgpyskggCSiGGKFSLVLvDEPDPDYDEVIESNGGPIYVDSYSLPFLDe 81

                          90       100
                  ....*....|....*....|....*....
gi 489911472   90 GAEIDYKEDLEGAQFVIRNPNASTTCGCG 118
Cdd:pfam01521  82 GLTLDFVEDLGTLGLKSDNGNLDGNVGCG 110
sufA PRK09504
iron-sulfur cluster assembly scaffold protein; Provisional
 18-123 4.21e-15

iron-sulfur cluster assembly scaffold protein; Provisional


Pssm-ID: 181915  Cd Length: 122  Bit Score: 66.30  E-value: 4.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  18 LVFTDSAAAKVKDLLAEegNPELK-LRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYK 96
Cdd:PRK09504  18 LTLTPAAAAHIRELMAK--QPGMKgVRLGVKQTGCAGFGYVLDSVSEPDKDDLVFEHDGAKLFVPLQAMPFIDGTEVDYV 95

                         90       100
                 ....*....|....*....|....*..
gi 489911472  97 EDLEGAQFVIRNPNASTTCGCGSSFSV 123
Cdd:PRK09504  96 REGLNQIFKFHNPKAQNECGCGESFGV 122
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
21-111 1.16e-09

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 53.48  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  21 TDSAAAKVKDLLA--EEGNpelKLRVFVQGGGCSGFQYGFTF--DEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYK 96
Cdd:PRK11190   5 SDAAQAHFAKLLAnqEEGT---QIRVFVINPGTPNAECGVSYcpPDAVEATDTELKFDGFSAYVDELSAPFLEDAEIDFV 81

                         90
                 ....*....|....*
gi 489911472  97 EDLEGAQFVIRNPNA 111
Cdd:PRK11190  82 TDQLGSQLTLKAPNA 96
IscA_HesB_Se NF038090
IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, ...
 21-119 5.93e-06

IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, are homologous to proteins of iron-sulfur cluster biosynthesis such as IscA, and belong to the broader set of HesB-related proteins.


Pssm-ID: 411672  Cd Length: 99  Bit Score: 41.93  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489911472  21 TDSAAAKVKDLLAEEgNPELKLRVFVQGGGCSGFQYGFTFDEvVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYKEDLE 100
Cdd:NF038090   5 TDLASRKLKEYFADK-KIDSPIRVFLNQGGUAGPSLGLALDE-PKENDEVFEQDGLTFVIDKELLEQCGPIKVDFIDCRS 82

                         90
                 ....*....|....*....
gi 489911472 101 GaqFVIRNPNASTTCGCGS 119
Cdd:NF038090  83 G--FSITSSMPLGGGGCGS 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH