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Conserved domains on  [gi|489925627|ref|WP_003828967|]
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MULTISPECIES: iron donor protein CyaY [Citrobacter]

Protein Classification

iron donor protein CyaY( domain architecture ID 10011442)

iron donor protein CyaY is involved in iron-sulfur (Fe-S) cluster assembly and may act as a regulator of Fe-S biogenesis

CATH:  3.30.920.10
Gene Ontology:  GO:0008198|GO:0016226|GO:0008199
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cyaY PRK00446
frataxin-like protein; Provisional
 1-106 6.35e-58

frataxin-like protein; Provisional


:

Pssm-ID: 234765  Cd Length: 105  Bit Score: 173.53  E-value: 6.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIdCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDADID-CERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKDGEWIC 79

                         90       100
                 ....*....|....*....|....*.
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSFR 106
Cdd:PRK00446  80 DRSGEEFWALLEEAATQQAGEPVSFR 105
 
Name Accession Description Interval E-value
cyaY PRK00446
frataxin-like protein; Provisional
 1-106 6.35e-58

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 173.53  E-value: 6.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIdCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDADID-CERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKDGEWIC 79

                         90       100
                 ....*....|....*....|....*.
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSFR 106
Cdd:PRK00446  80 DRSGEEFWALLEEAATQQAGEPVSFR 105
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 1-106 1.18e-51

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 157.65  E-value: 1.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIdCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:COG1965    1 MTESEFHQLADALLEAIEEALDRDDDADID-CERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAKSGGFHFDYDDGKWID 79

                         90       100
                 ....*....|....*....|....*.
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSFR 106
Cdd:COG1965   80 TRSGEELFALLSRALSEQAGEPVTLA 105
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 1-105 2.05e-50

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 154.73  E-value: 2.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIDCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:cd00503    1 MNESEFHRLADDLLLKIEDTLEEQDDDADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKVGGYHFDYKNGKWIC 80

                         90       100
                 ....*....|....*....|....*
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSF 105
Cdd:cd00503   81 TRSGEELWELLEEECSAQSGEDVEF 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 2-105 1.47e-47

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 147.36  E-value: 1.47e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627    2 NDSEFHRLADTLWMTIEERLDDWDGDSDidCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICD 81
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADID--CERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDGGAWIDT 78

                          90       100
                  ....*....|....*....|....
gi 489925627   82 RSGETFWDLLEQAATQQAGEEVSF 105
Cdd:TIGR03421  79 RDGEELWALLARACSEQAGEPVVF 102
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 1-103 3.68e-40

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 128.80  E-value: 3.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627    1 MNDSEFHRLADTLWMTIEERLDDWDGDSDID-CEINGGVLTISFENGSKIIINRQEPLHQVWLATK-QGGYHFDLKG-DE 77
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGSDAdVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPiSGPFHFDYDDaGQ 80

                          90       100
                  ....*....|....*....|....*.
gi 489925627   78 WICDRSGETFWDLLEQAATQQAGEEV 103
Cdd:pfam01491  81 WIYTRDGEELFELLSRELSEQLGEPV 106
 
Name Accession Description Interval E-value
cyaY PRK00446
frataxin-like protein; Provisional
 1-106 6.35e-58

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 173.53  E-value: 6.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIdCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDADID-CERNGGVLTLTFENGSKIIINRQEPLHELWLAAKSGGFHFDYKDGEWIC 79

                         90       100
                 ....*....|....*....|....*.
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSFR 106
Cdd:PRK00446  80 DRSGEEFWALLEEAATQQAGEPVSFR 105
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 1-106 1.18e-51

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 157.65  E-value: 1.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIdCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:COG1965    1 MTESEFHQLADALLEAIEEALDRDDDADID-CERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAKSGGFHFDYDDGKWID 79

                         90       100
                 ....*....|....*....|....*.
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSFR 106
Cdd:COG1965   80 TRSGEELFALLSRALSEQAGEPVTLA 105
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 1-105 2.05e-50

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 154.73  E-value: 2.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIDCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWIC 80
Cdd:cd00503    1 MNESEFHRLADDLLLKIEDTLEEQDDDADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKVGGYHFDYKNGKWIC 80

                         90       100
                 ....*....|....*....|....*
gi 489925627  81 DRSGETFWDLLEQAATQQAGEEVSF 105
Cdd:cd00503   81 TRSGEELWELLEEECSAQSGEDVEF 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 2-105 1.47e-47

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 147.36  E-value: 1.47e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627    2 NDSEFHRLADTLWMTIEERLDDWDGDSDidCEINGGVLTISFENGSKIIINRQEPLHQVWLATKQGGYHFDLKGDEWICD 81
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDDGDADID--CERQGGVLTLTFENGSQIIINKQEPLHQIWLAAKSGGFHFDYDGGAWIDT 78

                          90       100
                  ....*....|....*....|....
gi 489925627   82 RSGETFWDLLEQAATQQAGEEVSF 105
Cdd:TIGR03421  79 RDGEELWALLARACSEQAGEPVVF 102
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 1-103 3.68e-40

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 128.80  E-value: 3.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627    1 MNDSEFHRLADTLWMTIEERLDDWDGDSDID-CEINGGVLTISFENGSKIIINRQEPLHQVWLATK-QGGYHFDLKG-DE 77
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGSDAdVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPiSGPFHFDYDDaGQ 80

                          90       100
                  ....*....|....*....|....*.
gi 489925627   78 WICDRSGETFWDLLEQAATQQAGEEV 103
Cdd:pfam01491  81 WIYTRDGEELFELLSRELSEQLGEPV 106
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 5-93 5.35e-13

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 59.56  E-value: 5.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489925627    5 EFHRLAD----TLWMTIEErLDDWDGDSDIDCEINGGVLTISFENGSKIIINRQEPLHQVWLAT-KQGGYHFDLKGDEWI 79
Cdd:TIGR03422   1 EYHKVADeyldHLLDKLEE-LGESRPDLDFDVEYSSGVLTLELPSVGTYVINKQPPNKQIWLSSpVSGPKRYDYVNGEWI 79

                          90
                  ....*....|....
gi 489925627   80 CDRSGETFWDLLEQ 93
Cdd:TIGR03422  80 YLRDGSSLTELLEE 93
cyaY PRK01379
iron donor protein CyaY;
1-78 2.51e-06

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 42.61  E-value: 2.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489925627   1 MNDSEFHRLADTLWMTIEERLDDWDGDSDIDCEINGGVLTISFENGSkIIINRQEPLHQVWLATK-QGGYHFDLKGDEW 78
Cdd:PRK01379   1 MNNSEFSKIAETTIAYIADKIEEQDKEASIDVDLQGDILNLDTDKGI-YVINKQSAAKEIWLSSPvSGPYHFFYEQGKW 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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