|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
1-397 |
0e+00 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 703.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 1 MNKNRGLTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK15030 1 MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK15030 81 FKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK15030 161 KAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK15030 241 KAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGD 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEITADNNQQGQSGSQPEQSKS 397
Cdd:PRK15030 321 ATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS 397
|
|
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
44-381 |
3.42e-92 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 279.91 E-value: 3.42e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 44 TLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQ 123
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 124 LTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQatAL 203
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 204 ATVQQLDPIYVDVTQSSNDFLRLKQelangtlkqengKAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNP 283
Cdd:COG0845 160 FTIADLDPLEVEFDVPESDLARLKV------------GQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 284 DHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDaSALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTG 363
Cdd:COG0845 228 DGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSG 306
|
330
....*....|....*...
gi 489927712 364 LQKVRPGAQVKAQEITAD 381
Cdd:COG0845 307 LQRLRDGAKVRVVEAAAP 324
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
49-361 |
7.08e-78 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 243.48 E-value: 7.08e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 49 PLQITTELPGRTSAFRIAE-VRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVK 127
Cdd:pfam00529 3 PLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 128 RYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQ 207
Cdd:pfam00529 83 RLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 208 QLDPIYVDVTQSSNDFLRL-KQELANGTLKQENGKAKVELVTNDG----IKFPQSGTLEFSDVTVDQTTGSITLRAIFPN 282
Cdd:pfam00529 163 QLDQIYVQITQSAAENQAEvRSELSGAQLQIAEAEAELKLAKLDLerteIRAPVDGTVAFLSVTVDGGTVSAGLRLMFVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 283 PDHTLL-PGMFVRARLEEGINPTALLVPQQGVTRTPRGDASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIV 361
Cdd:pfam00529 243 PEDNLLvPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
40-376 |
5.80e-77 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 241.06 E-value: 5.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 40 VGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAA 119
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 120 NIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQ 199
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 200 atALATVQQLDPIYVDVTQSSNDFLRLKqelangtlkqENGKAKVELVTNDGIKFPqsGTLEFSDVTVDQTTGSITLRAI 279
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLR----------RGQTLTVELDALPGEEFK--GKLRFIDPRVDSGTGTVRVRAT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 280 FPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDAsALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRV 359
Cdd:TIGR01730 227 FPNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKY-VYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQI 305
|
330
....*....|....*..
gi 489927712 360 IVTGLQKVRPGAQVKAQ 376
Cdd:TIGR01730 306 VTAGVVKLRDGAKVKVV 322
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
1-397 |
0e+00 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 703.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 1 MNKNRGLTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK15030 1 MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK15030 81 FKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK15030 161 KAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK15030 241 KAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGD 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEITADNNQQGQSGSQPEQSKS 397
Cdd:PRK15030 321 ATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS 397
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
1-391 |
1.89e-135 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 392.54 E-value: 1.89e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 1 MNKNRgltPLAVVLMLSGSLaLTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK09859 1 MNRRR---KLLIPLLFCGAM-LTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK09859 77 FIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK09859 157 KAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK09859 237 STPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGK 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGaqVKAQEITADNNQQGQSGSQ 391
Cdd:PRK09859 317 ATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPG--IKARAISSSQENASTESKQ 385
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
4-388 |
2.42e-94 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 287.85 E-value: 2.42e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 4 NRGLTPLAVVLMLsgslALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTE 83
Cdd:PRK09578 6 RRRLLLAALVALF----VLAGCGKGDSDAAAAAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 84 GGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAA 163
Cdd:PRK09578 82 GQEVKQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 164 VETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLK-QENGKA 242
Cdd:PRK09578 162 LARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVEALRRAVKSGRATgIAQQDV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 243 KVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPrGDAS 322
Cdd:PRK09578 242 AVTLVRADGSEYPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALDRAVNPRAILVPRDALLRTA-DSAS 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489927712 323 ALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEiTADNNQQGQS 388
Cdd:PRK09578 321 VKVVGQNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVKAVE-RAPAAKPAPG 385
|
|
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
44-381 |
3.42e-92 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 279.91 E-value: 3.42e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 44 TLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQ 123
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 124 LTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQatAL 203
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 204 ATVQQLDPIYVDVTQSSNDFLRLKQelangtlkqengKAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNP 283
Cdd:COG0845 160 FTIADLDPLEVEFDVPESDLARLKV------------GQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 284 DHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDaSALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTG 363
Cdd:COG0845 228 DGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSG 306
|
330
....*....|....*...
gi 489927712 364 LQKVRPGAQVKAQEITAD 381
Cdd:COG0845 307 LQRLRDGAKVRVVEAAAP 324
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
49-361 |
7.08e-78 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 243.48 E-value: 7.08e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 49 PLQITTELPGRTSAFRIAE-VRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVK 127
Cdd:pfam00529 3 PLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 128 RYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQ 207
Cdd:pfam00529 83 RLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 208 QLDPIYVDVTQSSNDFLRL-KQELANGTLKQENGKAKVELVTNDG----IKFPQSGTLEFSDVTVDQTTGSITLRAIFPN 282
Cdd:pfam00529 163 QLDQIYVQITQSAAENQAEvRSELSGAQLQIAEAEAELKLAKLDLerteIRAPVDGTVAFLSVTVDGGTVSAGLRLMFVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 283 PDHTLL-PGMFVRARLEEGINPTALLVPQQGVTRTPRGDASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIV 361
Cdd:pfam00529 243 PEDNLLvPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
40-376 |
5.80e-77 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 241.06 E-value: 5.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 40 VGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAA 119
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 120 NIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQ 199
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 200 atALATVQQLDPIYVDVTQSSNDFLRLKqelangtlkqENGKAKVELVTNDGIKFPqsGTLEFSDVTVDQTTGSITLRAI 279
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLR----------RGQTLTVELDALPGEEFK--GKLRFIDPRVDSGTGTVRVRAT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 280 FPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDAsALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRV 359
Cdd:TIGR01730 227 FPNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKY-VYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQI 305
|
330
....*....|....*..
gi 489927712 360 IVTGLQKVRPGAQVKAQ 376
Cdd:TIGR01730 306 VTAGVVKLRDGAKVKVV 322
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
58-396 |
8.23e-39 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 143.78 E-value: 8.23e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 58 GRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKY 137
Cdd:PRK11556 80 GTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTNL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 138 ISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVT 217
Cdd:PRK11556 160 VSRQELDAQQALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFT 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 218 QSSNDFLRLKQelangtlKQENGKA-KVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRAR 296
Cdd:PRK11556 240 LPESDIATVVQ-------AQKAGKPlVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNAR 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 297 LEEGINPTALLVPQQGVTRTPRGDAsALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQ 376
Cdd:PRK11556 313 MLVDTLQNAVVIPTAALQMGNEGHF-VWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVV 391
|
330 340
....*....|....*....|
gi 489927712 377 EITADNNQQGQSGSQPEQSK 396
Cdd:PRK11556 392 EPQSATTPEEKATSREYAKK 411
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
64-300 |
1.51e-16 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 80.09 E-value: 1.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 64 RIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIA--------------------- 122
Cdd:COG1566 44 RVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQLAAAEAQLARLeaelgaeaeiaaaeaqlaaaq 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 123 ------QLTVKRYQKLLGTKYISQQDYDSA---------------------------LADAQQANAAVVAAKAAVETARI 169
Cdd:COG1566 124 aqldlaQRELERYQALYKKGAVSQQELDEAraaldaaqaqleaaqaqlaqaqaglreEEELAAAQAQVAQAEAALAQAEL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 170 NLAYTKVTSPISGRIGKSSVTEGALVQNGQatALATVQQLDPIYVDVTQSSNDFLRLKQ----ELANGTLKQENGKAKVE 245
Cdd:COG1566 204 NLARTTIRAPVDGVVTNLNVEPGEVVSAGQ--PLLTIVPLDDLWVEAYVPETDLGRVKPgqpvEVRVDAYPDRVFEGKVT 281
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 489927712 246 LVTNDGIKFPQSGTLEFSDVTVdqttgsITLRAIFPNPD-HTLLPGMFVRARLEEG 300
Cdd:COG1566 282 SISPGAGFTSPPKNATGNVVQR------YPVRIRLDNPDpEPLRPGMSATVEIDTE 331
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
58-361 |
3.12e-08 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 55.17 E-value: 3.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 58 GRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQ-------AAYESAKGDLAKAQAAANIAQLTVKRYQ 130
Cdd:PRK11578 54 GKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAEnqikeveATLMELRAQRQQAEAELKLARVTLSRQQ 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 131 KLLGTKYISQQDYDSALADAQQANAAVVA-------AKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQ-ATA 202
Cdd:PRK11578 134 RLAKTQAVSQQDLDTAATELAVKQAQIGTidaqikrNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQqAPN 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 203 LATVQQLDPIYVDVTQSSNDFLRLKQELangtlkqengKAKVELVTNDGIKFPqsGTLEFSDVTVDQTTGSITLRAIF-- 280
Cdd:PRK11578 214 ILTLADMSTMLVKAQVSEADVIHLKPGQ----------KAWFTVLGDPLTRYE--GVLKDILPTPEKVNDAIFYYARFev 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 281 PNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVI 360
Cdd:PRK11578 282 PNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEVI 361
|
.
gi 489927712 361 V 361
Cdd:PRK11578 362 I 362
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
176-293 |
6.35e-08 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 52.51 E-value: 6.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 176 VTSPISGRIGKSSVTEGALVQNGQAtaLATVQQLDP--IYVDVTQSSNDFLRLKQelangtlkqengKAKVELVTNDGIK 253
Cdd:pfam16576 111 VYAPISGVVTELNVREGMYVQPGDT--LFTIADLSTvwVEADVPEQDLALVKVGQ------------PAEVTLPALPGKT 176
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489927712 254 FPqsGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFV 293
Cdd:pfam16576 177 FE--GKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGMFA 214
|
|
| PRK09783 |
PRK09783 |
copper/silver efflux system membrane fusion protein CusB; Provisional |
266-364 |
8.59e-06 |
|
copper/silver efflux system membrane fusion protein CusB; Provisional
Pssm-ID: 236625 [Multi-domain] Cd Length: 409 Bit Score: 47.55 E-value: 8.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 266 TVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTaLLVPQQGVTRTPRgDASALVIGADNKVETRQIVAAQAIGD 345
Cdd:PRK09783 288 SVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTASEPM-LLIPSQALIDTGS-EQRVITVDADGRFVPKRVAVFQESQG 365
|
90
....*....|....*....
gi 489927712 346 KWLVTDGLKPGDRVIVTGL 364
Cdd:PRK09783 366 VTAIRSGLAEGEKVVSSGL 384
|
|
| PRK10559 |
PRK10559 |
p-hydroxybenzoic acid efflux pump subunit AaeA; |
70-214 |
8.78e-06 |
|
p-hydroxybenzoic acid efflux pump subunit AaeA;
Pssm-ID: 182548 [Multi-domain] Cd Length: 310 Bit Score: 47.04 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 70 PQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKlLGTKYISQQDYDSALAD 149
Cdd:PRK10559 52 PDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALAEAEADVAYYQVLAQEKRREAGRRNR-LGVQAMSREEIDQANNV 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489927712 150 AQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGqATALATVQQlDPIYV 214
Cdd:PRK10559 131 LQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRG-STAVALVKQ-NSFYV 193
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
175-290 |
1.09e-04 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 41.19 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 175 KVTSPISGRIGKSSVTEGALVQNGQatALATVQQLDPIYVDVTQSSNDFLRLKQElangtlkqengkAKVELVTNDGIKF 254
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGD--PLATIVPPDRLLVEAFVPAADLGSLKKG------------QKVTLKLDPGSDY 66
|
90 100 110
....*....|....*....|....*....|....*...
gi 489927712 255 PQSGTLEFSDVTVDQTTGSITLRAIFPNPDH--TLLPG 290
Cdd:pfam13437 67 TLEGKVVRISPTVDPDTGVIPVRVSIENPKTpiPLLPG 104
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
65-146 |
1.99e-03 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 40.01 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 65 IAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQL-------------------- 124
Cdd:PRK10476 48 VVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYELTVAQAQADLALADAQIMTTQRsvdaersnaasaneqverar 127
|
90 100 110
....*....|....*....|....*....|
gi 489927712 125 --------TVKRYQKLLGTKYISQQDYDSA 146
Cdd:PRK10476 128 anaklatrTLERLEPLLAKGYVSAQQVDQA 157
|
|
|