NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489927712|ref|WP_003831044|]
View 

MULTISPECIES: multidrug efflux RND transporter periplasmic adaptor subunit AcrA [Citrobacter]

Protein Classification

multidrug efflux RND transporter periplasmic adaptor subunit AcrA( domain architecture ID 11487574)

multidrug efflux RND transporter periplasmic adaptor subunit AcrA is a component of a drug efflux protein complex AcrA-AcrB-AcrZ-TolC with broad substrate specificity that uses the proton motive force to export substrates; may act as an adapter protein that links AcrB and TolC stably together

CATH:  1.20.1600.10
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  4003096

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-397 0e+00

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


:

Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 703.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   1 MNKNRGLTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK15030   1 MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK15030  81 FKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK15030 161 KAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK15030 241 KAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGD 320
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEITADNNQQGQSGSQPEQSKS 397
Cdd:PRK15030 321 ATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS 397
 
Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-397 0e+00

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 703.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   1 MNKNRGLTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK15030   1 MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK15030  81 FKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK15030 161 KAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK15030 241 KAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGD 320
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEITADNNQQGQSGSQPEQSKS 397
Cdd:PRK15030 321 ATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS 397
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
44-381 3.42e-92

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 279.91  E-value: 3.42e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  44 TLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQ 123
Cdd:COG0845    2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 124 LTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQatAL 203
Cdd:COG0845   82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 204 ATVQQLDPIYVDVTQSSNDFLRLKQelangtlkqengKAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNP 283
Cdd:COG0845  160 FTIADLDPLEVEFDVPESDLARLKV------------GQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNP 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 284 DHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDaSALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTG 363
Cdd:COG0845  228 DGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSG 306
                        330
                 ....*....|....*...
gi 489927712 364 LQKVRPGAQVKAQEITAD 381
Cdd:COG0845  307 LQRLRDGAKVRVVEAAAP 324
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
49-361 7.08e-78

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 243.48  E-value: 7.08e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   49 PLQITTELPGRTSAFRIAE-VRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVK 127
Cdd:pfam00529   3 PLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  128 RYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQ 207
Cdd:pfam00529  83 RLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  208 QLDPIYVDVTQSSNDFLRL-KQELANGTLKQENGKAKVELVTNDG----IKFPQSGTLEFSDVTVDQTTGSITLRAIFPN 282
Cdd:pfam00529 163 QLDQIYVQITQSAAENQAEvRSELSGAQLQIAEAEAELKLAKLDLerteIRAPVDGTVAFLSVTVDGGTVSAGLRLMFVV 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  283 PDHTLL-PGMFVRARLEEGINPTALLVPQQGVTRTPRGDASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIV 361
Cdd:pfam00529 243 PEDNLLvPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
40-376 5.80e-77

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 241.06  E-value: 5.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   40 VGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAA 119
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  120 NIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQ 199
Cdd:TIGR01730  81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  200 atALATVQQLDPIYVDVTQSSNDFLRLKqelangtlkqENGKAKVELVTNDGIKFPqsGTLEFSDVTVDQTTGSITLRAI 279
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLR----------RGQTLTVELDALPGEEFK--GKLRFIDPRVDSGTGTVRVRAT 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  280 FPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDAsALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRV 359
Cdd:TIGR01730 227 FPNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKY-VYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQI 305
                         330
                  ....*....|....*..
gi 489927712  360 IVTGLQKVRPGAQVKAQ 376
Cdd:TIGR01730 306 VTAGVVKLRDGAKVKVV 322
 
Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-397 0e+00

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 703.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   1 MNKNRGLTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK15030   1 MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK15030  81 FKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK15030 161 KAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK15030 241 KAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGD 320
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEITADNNQQGQSGSQPEQSKS 397
Cdd:PRK15030 321 ATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS 397
PRK09859 PRK09859
multidrug transporter subunit MdtE;
1-391 1.89e-135

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 392.54  E-value: 1.89e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   1 MNKNRgltPLAVVLMLSGSLaLTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRN 80
Cdd:PRK09859   1 MNRRR---KLLIPLLFCGAM-LTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRN 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  81 FTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAA 160
Cdd:PRK09859  77 FIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 161 KAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENG 240
Cdd:PRK09859 157 KAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQG 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 241 KAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGD 320
Cdd:PRK09859 237 STPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGK 316
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489927712 321 ASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGaqVKAQEITADNNQQGQSGSQ 391
Cdd:PRK09859 317 ATALILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPG--IKARAISSSQENASTESKQ 385
PRK09578 PRK09578
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
4-388 2.42e-94

MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 169982 [Multi-domain]  Cd Length: 385  Bit Score: 287.85  E-value: 2.42e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   4 NRGLTPLAVVLMLsgslALTGCDDKQAQQGGQQMPEVGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTE 83
Cdd:PRK09578   6 RRRLLLAALVALF----VLAGCGKGDSDAAAAAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  84 GGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAA 163
Cdd:PRK09578  82 GQEVKQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 164 VETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLK-QENGKA 242
Cdd:PRK09578 162 LARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVEALRRAVKSGRATgIAQQDV 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 243 KVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPrGDAS 322
Cdd:PRK09578 242 AVTLVRADGSEYPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALDRAVNPRAILVPRDALLRTA-DSAS 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489927712 323 ALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQEiTADNNQQGQS 388
Cdd:PRK09578 321 VKVVGQNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVKAVE-RAPAAKPAPG 385
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
44-381 3.42e-92

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 279.91  E-value: 3.42e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  44 TLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQ 123
Cdd:COG0845    2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 124 LTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQatAL 203
Cdd:COG0845   82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 204 ATVQQLDPIYVDVTQSSNDFLRLKQelangtlkqengKAKVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNP 283
Cdd:COG0845  160 FTIADLDPLEVEFDVPESDLARLKV------------GQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNP 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 284 DHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDaSALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTG 363
Cdd:COG0845  228 DGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSG 306
                        330
                 ....*....|....*...
gi 489927712 364 LQKVRPGAQVKAQEITAD 381
Cdd:COG0845  307 LQRLRDGAKVRVVEAAAP 324
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
49-361 7.08e-78

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 243.48  E-value: 7.08e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   49 PLQITTELPGRTSAFRIAE-VRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVK 127
Cdd:pfam00529   3 PLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELD 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  128 RYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQ 207
Cdd:pfam00529  83 RLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  208 QLDPIYVDVTQSSNDFLRL-KQELANGTLKQENGKAKVELVTNDG----IKFPQSGTLEFSDVTVDQTTGSITLRAIFPN 282
Cdd:pfam00529 163 QLDQIYVQITQSAAENQAEvRSELSGAQLQIAEAEAELKLAKLDLerteIRAPVDGTVAFLSVTVDGGTVSAGLRLMFVV 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  283 PDHTLL-PGMFVRARLEEGINPTALLVPQQGVTRTPRGDASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIV 361
Cdd:pfam00529 243 PEDNLLvPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
40-376 5.80e-77

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 241.06  E-value: 5.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712   40 VGVVTLKTEPLQITTELPGRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAA 119
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  120 NIAQLTVKRYQKLLGTKYISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQ 199
Cdd:TIGR01730  81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  200 atALATVQQLDPIYVDVTQSSNDFLRLKqelangtlkqENGKAKVELVTNDGIKFPqsGTLEFSDVTVDQTTGSITLRAI 279
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLR----------RGQTLTVELDALPGEEFK--GKLRFIDPRVDSGTGTVRVRAT 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  280 FPNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDAsALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRV 359
Cdd:TIGR01730 227 FPNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKY-VYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQI 305
                         330
                  ....*....|....*..
gi 489927712  360 IVTGLQKVRPGAQVKAQ 376
Cdd:TIGR01730 306 VTAGVVKLRDGAKVKVV 322
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
58-396 8.23e-39

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 143.78  E-value: 8.23e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  58 GRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKLLGTKY 137
Cdd:PRK11556  80 GTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTNL 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 138 ISQQDYDSALADAQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQATALATVQQLDPIYVDVT 217
Cdd:PRK11556 160 VSRQELDAQQALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFT 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 218 QSSNDFLRLKQelangtlKQENGKA-KVELVTNDGIKFPQSGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRAR 296
Cdd:PRK11556 240 LPESDIATVVQ-------AQKAGKPlVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNAR 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 297 LEEGINPTALLVPQQGVTRTPRGDAsALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVIVTGLQKVRPGAQVKAQ 376
Cdd:PRK11556 313 MLVDTLQNAVVIPTAALQMGNEGHF-VWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVV 391
                        330       340
                 ....*....|....*....|
gi 489927712 377 EITADNNQQGQSGSQPEQSK 396
Cdd:PRK11556 392 EPQSATTPEEKATSREYAKK 411
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
64-300 1.51e-16

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 80.09  E-value: 1.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  64 RIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIA--------------------- 122
Cdd:COG1566   44 RVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQLAAAEAQLARLeaelgaeaeiaaaeaqlaaaq 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 123 ------QLTVKRYQKLLGTKYISQQDYDSA---------------------------LADAQQANAAVVAAKAAVETARI 169
Cdd:COG1566  124 aqldlaQRELERYQALYKKGAVSQQELDEAraaldaaqaqleaaqaqlaqaqaglreEEELAAAQAQVAQAEAALAQAEL 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 170 NLAYTKVTSPISGRIGKSSVTEGALVQNGQatALATVQQLDPIYVDVTQSSNDFLRLKQ----ELANGTLKQENGKAKVE 245
Cdd:COG1566  204 NLARTTIRAPVDGVVTNLNVEPGEVVSAGQ--PLLTIVPLDDLWVEAYVPETDLGRVKPgqpvEVRVDAYPDRVFEGKVT 281
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489927712 246 LVTNDGIKFPQSGTLEFSDVTVdqttgsITLRAIFPNPD-HTLLPGMFVRARLEEG 300
Cdd:COG1566  282 SISPGAGFTSPPKNATGNVVQR------YPVRIRLDNPDpEPLRPGMSATVEIDTE 331
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
58-361 3.12e-08

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 55.17  E-value: 3.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  58 GRTSAFRIAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQ-------AAYESAKGDLAKAQAAANIAQLTVKRYQ 130
Cdd:PRK11578  54 GKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAEnqikeveATLMELRAQRQQAEAELKLARVTLSRQQ 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 131 KLLGTKYISQQDYDSALADAQQANAAVVA-------AKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGQ-ATA 202
Cdd:PRK11578 134 RLAKTQAVSQQDLDTAATELAVKQAQIGTidaqikrNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQqAPN 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 203 LATVQQLDPIYVDVTQSSNDFLRLKQELangtlkqengKAKVELVTNDGIKFPqsGTLEFSDVTVDQTTGSITLRAIF-- 280
Cdd:PRK11578 214 ILTLADMSTMLVKAQVSEADVIHLKPGQ----------KAWFTVLGDPLTRYE--GVLKDILPTPEKVNDAIFYYARFev 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 281 PNPDHTLLPGMFVRARLEEGINPTALLVPQQGVTRTPRGDASALVIGADNKVETRQIVAAQAIGDKWLVTDGLKPGDRVI 360
Cdd:PRK11578 282 PNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEVI 361

                 .
gi 489927712 361 V 361
Cdd:PRK11578 362 I 362
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
176-293 6.35e-08

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 52.51  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  176 VTSPISGRIGKSSVTEGALVQNGQAtaLATVQQLDP--IYVDVTQSSNDFLRLKQelangtlkqengKAKVELVTNDGIK 253
Cdd:pfam16576 111 VYAPISGVVTELNVREGMYVQPGDT--LFTIADLSTvwVEADVPEQDLALVKVGQ------------PAEVTLPALPGKT 176
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489927712  254 FPqsGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFV 293
Cdd:pfam16576 177 FE--GKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGMFA 214
PRK09783 PRK09783
copper/silver efflux system membrane fusion protein CusB; Provisional
266-364 8.59e-06

copper/silver efflux system membrane fusion protein CusB; Provisional


Pssm-ID: 236625 [Multi-domain]  Cd Length: 409  Bit Score: 47.55  E-value: 8.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712 266 TVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPTaLLVPQQGVTRTPRgDASALVIGADNKVETRQIVAAQAIGD 345
Cdd:PRK09783 288 SVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTASEPM-LLIPSQALIDTGS-EQRVITVDADGRFVPKRVAVFQESQG 365
                         90
                 ....*....|....*....
gi 489927712 346 KWLVTDGLKPGDRVIVTGL 364
Cdd:PRK09783 366 VTAIRSGLAEGEKVVSSGL 384
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
70-214 8.78e-06

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 47.04  E-value: 8.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  70 PQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQLTVKRYQKlLGTKYISQQDYDSALAD 149
Cdd:PRK10559  52 PDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALAEAEADVAYYQVLAQEKRREAGRRNR-LGVQAMSREEIDQANNV 130
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489927712 150 AQQANAAVVAAKAAVETARINLAYTKVTSPISGRIGKSSVTEGALVQNGqATALATVQQlDPIYV 214
Cdd:PRK10559 131 LQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRG-STAVALVKQ-NSFYV 193
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
175-290 1.09e-04

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 41.19  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  175 KVTSPISGRIGKSSVTEGALVQNGQatALATVQQLDPIYVDVTQSSNDFLRLKQElangtlkqengkAKVELVTNDGIKF 254
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAGD--PLATIVPPDRLLVEAFVPAADLGSLKKG------------QKVTLKLDPGSDY 66
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489927712  255 PQSGTLEFSDVTVDQTTGSITLRAIFPNPDH--TLLPG 290
Cdd:pfam13437  67 TLEGKVVRISPTVDPDTGVIPVRVSIENPKTpiPLLPG 104
PRK10476 PRK10476
multidrug transporter subunit MdtN;
65-146 1.99e-03

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 40.01  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927712  65 IAEVRPQVSGIILKRNFTEGGDIEAGVSLYQIDPATYQAAYESAKGDLAKAQAAANIAQL-------------------- 124
Cdd:PRK10476  48 VVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYELTVAQAQADLALADAQIMTTQRsvdaersnaasaneqverar 127
                         90       100       110
                 ....*....|....*....|....*....|
gi 489927712 125 --------TVKRYQKLLGTKYISQQDYDSA 146
Cdd:PRK10476 128 anaklatrTLERLEPLLAKGYVSAQQVDQA 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH