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Conserved domains on  [gi|489928257|ref|WP_003831586|]
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MULTISPECIES: manganese-binding transcriptional regulator MntR [Citrobacter]

Protein Classification

manganese-binding transcriptional regulator MntR( domain architecture ID 11485168)

manganese-binding transcriptional regulator MntR, in the presence of manganese, represses the expression of mntH and mntS, and up-regulates the expression of mntP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-155 2.48e-91

manganese-binding transcriptional regulator MntR;


:

Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 261.87  E-value: 2.48e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257   4 RAGMPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGL 83
Cdd:PRK11050   1 RAGTPTAKKVTQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489928257  84 IEMIPWRGVFLTAEGERLAQESRERHQIVENFLLMLGISPEIARRDAEGMEHHVSKETLEAFSRFTQQQGTG 155
Cdd:PRK11050  81 VEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGAK 152
 
Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-155 2.48e-91

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 261.87  E-value: 2.48e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257   4 RAGMPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGL 83
Cdd:PRK11050   1 RAGTPTAKKVTQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489928257  84 IEMIPWRGVFLTAEGERLAQESRERHQIVENFLLMLGISPEIARRDAEGMEHHVSKETLEAFSRFTQQQGTG 155
Cdd:PRK11050  81 VEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGAK 152
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
31-148 3.61e-42

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 136.87  E-value: 3.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257  31 EAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLTAEGERLAQESRERHQ 110
Cdd:COG1321    1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489928257 111 IVENFLL-MLGISPEIARRDAEGMEHHVSKETLEAFSRF 148
Cdd:COG1321   81 LLERFLVeVLGVDWDEAHEEAERLEHVLSDETIERLDAF 119
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 59-150 4.69e-29

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 102.30  E-value: 4.69e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257    59 DMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLTAEGERLAQESRERHQIVENFLL-MLGISPEIARRDAEGMEHHV 137
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVdVLGVDEEEVHEEAERLEHVL 82

                           90
                   ....*....|...
gi 489928257   138 SKETLEAFSRFTQ 150
Cdd:smart00529  83 SDELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 95-148 3.75e-12

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 58.25  E-value: 3.75e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489928257   95 TAEGERLAQESRERHQIVENFLL-MLGISPEIARRDAEGMEHHVSKETLEAFSRF 148
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVdVLGVDWDEVHEEAERLEHALSDELIDRLDEF 55
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 35-95 2.20e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 2.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489928257  35 RELIDDYVELISDLIIEVGEA--RQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLT 95
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRlpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-155 2.48e-91

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 261.87  E-value: 2.48e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257   4 RAGMPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGL 83
Cdd:PRK11050   1 RAGTPTAKKVTQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489928257  84 IEMIPWRGVFLTAEGERLAQESRERHQIVENFLLMLGISPEIARRDAEGMEHHVSKETLEAFSRFTQQQGTG 155
Cdd:PRK11050  81 VEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGAK 152
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
31-148 3.61e-42

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 136.87  E-value: 3.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257  31 EAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLTAEGERLAQESRERHQ 110
Cdd:COG1321    1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489928257 111 IVENFLL-MLGISPEIARRDAEGMEHHVSKETLEAFSRF 148
Cdd:COG1321   81 LLERFLVeVLGVDWDEAHEEAERLEHVLSDETIERLDAF 119
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 59-150 4.69e-29

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 102.30  E-value: 4.69e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257    59 DMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLTAEGERLAQESRERHQIVENFLL-MLGISPEIARRDAEGMEHHV 137
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVdVLGVDEEEVHEEAERLEHVL 82

                           90
                   ....*....|...
gi 489928257   138 SKETLEAFSRFTQ 150
Cdd:smart00529  83 SDELEDRLDRFLG 95
PRK03902 PRK03902
transcriptional regulator MntR;
39-150 1.10e-21

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 84.66  E-value: 1.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257  39 DDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLTAEGERLAQESRERHQIVENFLLM 118
Cdd:PRK03902   7 EDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHELLEQFLRI 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489928257 119 LGISPEIARRDAEGMEHHVSKETLEAFSRFTQ 150
Cdd:PRK03902  87 IGVDESKIYNDVEGIEHHLSWNAIDRIGDLVQ 118
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 95-148 3.75e-12

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 58.25  E-value: 3.75e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489928257   95 TAEGERLAQESRERHQIVENFLL-MLGISPEIARRDAEGMEHHVSKETLEAFSRF 148
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVdVLGVDWDEVHEEAERLEHALSDELIDRLDEF 55
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 36-92 3.18e-09

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 50.06  E-value: 3.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489928257   36 ELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGV 92
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
47-124 1.60e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 41.43  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489928257    47 DLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRG------VFLTAEGERLAQESRERHQIVENfLLMLG 120
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEdrrsvlVSLTEEGRELIEQLLEARSETLA-ELLAG 95


                   ....
gi 489928257   121 ISPE 124
Cdd:smart00347  96 LTAE 99
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
53-110 3.86e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 41.11  E-value: 3.86e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489928257  53 GEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIP----WRG--VFLTAEGERLAQESRERHQ 110
Cdd:COG1846   51 GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPdpedRRAvlVRLTEKGRALLEEARPALE 114
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
61-107 6.57e-05

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 41.39  E-value: 6.57e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489928257  61 AARLGVSQPTVAKMLKRL-ASVG--LIEMIPwRGVFLTAEGERLAQESRE 107
Cdd:COG0583   22 AERLGVSQPAVSRQIRRLeEELGvpLFERTG-RGLRLTEAGERLLERARR 70
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
59-124 1.74e-04

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 39.01  E-value: 1.74e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489928257  59 DMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLTAEGERLAQESRER--HQIVENFL---LMLGISPE 124
Cdd:COG1725   39 ELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERREEflEEALRELVaeaRRLGLSLE 109
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 35-95 2.20e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 2.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489928257  35 RELIDDYVELISDLIIEVGEA--RQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVFLT 95
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRlpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
48-85 3.23e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.01  E-value: 3.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 489928257  48 LIIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIE 85
Cdd:COG3398  105 YLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVE 142
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
43-93 3.55e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 36.44  E-value: 3.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489928257  43 ELISDLIIEVGEA-RQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVF 93
Cdd:COG1802   22 EAILSGELPPGERlSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGAR 73
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 49-88 4.00e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.10  E-value: 4.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 489928257   49 IIEVGEARQVDMAARLGVSQPTVAKMLKRLASVGLIEMIP 88
Cdd:pfam12802  14 LARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
61-99 4.24e-03

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 33.90  E-value: 4.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 489928257   61 AARLGVSQPTVAKMLKRL-ASVG--LIEMIPwRGVFLTAEGE 99
Cdd:pfam00126  20 AERLGLSQPAVSRQIKRLeEELGvpLFERTT-RGVRLTEAGE 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 35-93 4.93e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 33.74  E-value: 4.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489928257   35 RELIDDYVELISDLIIEVGEA--RQVDMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVF 93
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKlpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTF 63
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 53-85 6.64e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 33.29  E-value: 6.64e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 489928257   53 GEARQVDMAARLGVSQPTVAKMLKRLASVGLIE 85
Cdd:pfam01047  16 GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
59-93 6.65e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 33.32  E-value: 6.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 489928257    59 DMAARLGVSQPTVAKMLKRLASVGLIEMIPWRGVF 93
Cdd:smart00345  25 ELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTF 59
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
53-86 7.13e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 34.09  E-value: 7.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 489928257  53 GEARQVDMAARLGVSQPTVAKMLKRLASVGLIEM 86
Cdd:COG0640   32 GELCVGELAEALGLSQSTVSHHLKVLREAGLVTS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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