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Conserved domains on  [gi|489931768|ref|WP_003835086|]
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MULTISPECIES: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Citrobacter]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10013199)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

EC:  6.3.2.6
Gene Ontology:  GO:0005524|GO:0004639

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-237 4.71e-144

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


:

Pssm-ID: 181800  Cd Length: 238  Bit Score: 401.79  E-value: 4.71e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   1 MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  81 VKKLEMVPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKAND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489931768 161 VLKKMFDDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGGLIEAYEAVAHRLGVKLD 237
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKdGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELLE 238
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-237 4.71e-144

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 401.79  E-value: 4.71e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   1 MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  81 VKKLEMVPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKAND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489931768 161 VLKKMFDDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGGLIEAYEAVAHRLGVKLD 237
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKdGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELLE 238
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-233 1.63e-127

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 359.84  E-value: 1.63e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   7 LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECLVKKLEM 86
Cdd:cd01415    2 LYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  87 VPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKANDVLKKMF 166
Cdd:cd01415   82 IPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEFF 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489931768 167 DDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGGLIEAYEAVAHRLG 233
Cdd:cd01415  162 AEIGIILVDFKLEFGRDKdGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLG 229
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-229 1.07e-118

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 337.83  E-value: 1.07e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768    1 MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:TIGR00081   3 IKKRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   81 VKKLEMVPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKAND 160
Cdd:TIGR00081  83 VKKLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNE 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489931768  161 VLKKMFDDAGLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLD----KMDKDRFRQSLGGLIEAYEAVA 229
Cdd:TIGR00081 163 VLKKYFDEKGIILVDFKLEFGLDeEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETVA 236
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-235 1.58e-111

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 320.10  E-value: 1.58e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   1 MQKQAELYRGKAKTVYSTENpDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  81 VKKLEMVPVECVVRNRAAGSLVKR--------LGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMK 152
Cdd:COG0152   80 VKKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 153 ELTYKANDVLKKMFDDAGLILVDFKLEFGL-YKGEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGG-LIEAYEAVAH 230
Cdd:COG0152  160 ELALKINERLSELAAERGIILVDTKLEFGRdADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGnTSEAYIEVLE 239


                 ....*
gi 489931768 231 RLGVK 235
Cdd:COG0152  240 RLTGE 244
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-226 1.32e-109

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 314.30  E-value: 1.32e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768    7 LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECLVKKLEM 86
Cdd:pfam01259   2 LYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVKI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   87 VPVECVVRNRAAGSLVKRL-GVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKANDVLKKM 165
Cdd:pfam01259  82 IPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKEY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489931768  166 FDDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETL----DKMDKDRFRQSLGGLIEAYE 226
Cdd:pfam01259 162 AAERGIILVDTKLEFGLDSdGEIVLADEITPDSSRFWDADTYeksqESLDKDRFRDDLGDVEEAYQ 227
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-237 4.71e-144

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 401.79  E-value: 4.71e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   1 MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:PRK09362   1 MEKKELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  81 VKKLEMVPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKAND 160
Cdd:PRK09362  81 VKKVEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKIND 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489931768 161 VLKKMFDDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGGLIEAYEAVAHRLGVKLD 237
Cdd:PRK09362 161 VLKGLFAGAGIRLVDFKLEFGRDKdGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGELLE 238
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 7-233 1.63e-127

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 359.84  E-value: 1.63e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   7 LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECLVKKLEM 86
Cdd:cd01415    2 LYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  87 VPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKANDVLKKMF 166
Cdd:cd01415   82 IPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEFF 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489931768 167 DDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGGLIEAYEAVAHRLG 233
Cdd:cd01415  162 AEIGIILVDFKLEFGRDKdGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLG 229
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 1-229 1.07e-118

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 337.83  E-value: 1.07e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768    1 MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:TIGR00081   3 IKKRQKLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   81 VKKLEMVPVECVVRNRAAGSLVKRLGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKAND 160
Cdd:TIGR00081  83 VKKLDIIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNE 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489931768  161 VLKKMFDDAGLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLD----KMDKDRFRQSLGGLIEAYEAVA 229
Cdd:TIGR00081 163 VLKKYFDEKGIILVDFKLEFGLDeEGNLILADEVSPDTCRLWDKETYEvgapKLDKDIFRRTLGKLIEAYETVA 236
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-235 1.58e-111

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 320.10  E-value: 1.58e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   1 MQKQAELYRGKAKTVYSTENpDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECL 80
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  81 VKKLEMVPVECVVRNRAAGSLVKR--------LGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMK 152
Cdd:COG0152   80 VKKLEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 153 ELTYKANDVLKKMFDDAGLILVDFKLEFGL-YKGEVVLGDEFSPDGSRLWDKETLDKMDKDRFRQSLGG-LIEAYEAVAH 230
Cdd:COG0152  160 ELALKINERLSELAAERGIILVDTKLEFGRdADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGnTSEAYIEVLE 239


                 ....*
gi 489931768 231 RLGVK 235
Cdd:COG0152  240 RLTGE 244
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 7-226 1.32e-109

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 314.30  E-value: 1.32e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768    7 LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECLVKKLEM 86
Cdd:pfam01259   2 LYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVKI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   87 VPVECVVRNRAAGSLVKRL-GVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKANDVLKKM 165
Cdd:pfam01259  82 IPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKEY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489931768  166 FDDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETL----DKMDKDRFRQSLGGLIEAYE 226
Cdd:pfam01259 162 AAERGIILVDTKLEFGLDSdGEIVLADEITPDSSRFWDADTYeksqESLDKDRFRDDLGDVEEAYQ 227
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 6-233 3.27e-108

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 310.93  E-value: 3.27e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   6 ELYRGKAKTVYSTENpDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECLVKKLE 85
Cdd:cd00476    1 TLYRGKTKIVYETKD-GVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  86 MVPVECVVRNRAAGSLVKRL-GVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGWVSKENLARMKELTYKANDVLKK 164
Cdd:cd00476   80 *IPLEVVVRNRATGSFVKRYgGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KELAVKINTVLKK 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489931768 165 MFDDAGLILVDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETLDKM-DKDRFRQSLGGLIEAYEAVAHRLG 233
Cdd:cd00476  160 LFSPAGLELWDFKLEFGLDEeGEIVLGDEISPDSSRLWRKGGEPYDkDLFRRRASLGQIIEKYEEVAELVR 230
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 7-232 5.77e-40

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 137.81  E-value: 5.77e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   7 LYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSDTECLVKKLE 85
Cdd:cd01416    7 LIEGKTKIVYElPDQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIARKCE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  86 MVPVECVVRNRAAGSLVKR-LGVEEGIELNPPLFDLFLKNDAMHDPMINDSYCETFGW------VSKENLARMKELTYKA 158
Cdd:cd01416   87 MIPIEWVCRRIATGSFLKRnPGVKEGYRFSPPKLEFFYKDDANHDPQWSEEQLLEAKLncgglkIGKKEVDIMTKSTIAI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 159 NDVLKKMFDDAGLILVDFKLEFGL--YKGEVVLGDEFSPDGSRLW---DKE-TLDKmdkdrfrQSLGGLIEA-------- 224
Cdd:cd01416  167 FEILEKAWATQDCTLVDMKIEFGVdvTTGEILLADVIDNDSWRLWpsgDKRlMKDK-------QVYRNLKEVtdealqev 239

                        250
                 ....*....|.
gi 489931768 225 ---YEAVAHRL 232
Cdd:cd01416  240 kknYEWVADKL 250
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 7-218 1.46e-31

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 116.88  E-value: 1.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   7 LYRGKAKTVYSTENpDLLVLEFRNdtsagdgaRIEQFDR--------KGMVNNKF-------------NHFIMTKLQEAg 65
Cdd:cd01414    2 IYSGKVRDVYDLGD-GRLLFVATD--------RISAFDVilppdipgKGEVLTQIsafwfeltediipNHLISTDVEDL- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  66 IPTQMERLLSDTECLVKKLEMVPVECVVRNRAAGSLVKRL---GVEEGIELNP----------PLFDLFLKNDAMHDpmI 132
Cdd:cd01414   72 PEIKEPEDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYqkgGTVCGIKLPEglreaqklpePIFTPSTKAEEGHD--E 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 133 NDSYCETFGWVSKENLARMKELTYKANDVLKKMFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKET----- 205
Cdd:cd01414  150 NISFEEAVEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDEnGEIILIDEVlTPDSSRFWPADSyepgk 229

                        250
                 ....*....|....
gi 489931768 206 -LDKMDKDRFRQSL 218
Cdd:cd01414  230 eQPSFDKQFVRDWL 243
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 7-205 1.15e-19

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 85.25  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   7 LYRGKAKTVYSTENPDLLVLefrndtsAGDgaRIEQFD--------RKG-----MVNNKF--------NHFIMTKLQEaG 65
Cdd:PRK13961  15 LGRGKVRDIYAVDDDRLLMV-------ATD--RISAFDvilpepipDKGrvltqMSNFWFdklahivpNHLTGIDVDD-V 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  66 IPTQMERLLSDTECLVKKLEMVPVECVVRNRAAGSLVK-----------RL--GVEEGIELNPPLFDLFLKNDA-MHDpm 131
Cdd:PRK13961  85 VPADEADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKdyqatgtvcgiKLpaGLVEASKLPEPIFTPATKAELgDHD-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 132 INDSYCETFGWVSKENLARMKELT---YK--ANDVLKKmfddaGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDKE 204
Cdd:PRK13961 163 ENISFEEVVELVGAELAAQLRDATlaiYKeaADYAATR-----GIIIADTKFEFGLDEdGTLTLMDEvLTPDSSRFWPAD 237


                 .
gi 489931768 205 T 205
Cdd:PRK13961 238 S 238
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 3-216 2.45e-13

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 67.99  E-value: 2.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   3 KQAELYRGKAKTVYSTENpDLLVLefrndtSAGDgaRIEQFDR-------KGMVNNKFNHFIMTKLQEAgIPTQmerLLS 75
Cdd:PRK12607  14 ELPNVYRGKVRDNYDLPD-GRRVM------VATD--RISAFDRvlpaipyKGQVLNQTAAFWFEATKDI-CPNH---VLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  76 --DTECLV-KKLEMVPVECVVRNRAAGSLVK--RLGVEE--GIELnpPlfDLFLKNDAM---------------HDPMIN 133
Cdd:PRK12607  81 vpDPNVVVgKRCEPFPVEMVVRGYLAGSTWRlyKAGKREmyGVTL--P--DGLRENQKLpepiitpttkaeeggHDEPIS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 134 DSYCETFGWVSKENLARMKELTYKANDVLKKMFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLDkmdk 211
Cdd:PRK12607 157 PEEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDAdGRIVLIDEIhTPDSSRYWYADGYE---- 232


                 ....*
gi 489931768 212 DRFRQ 216
Cdd:PRK12607 233 ERFAA 237
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 9-200 2.20e-10

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 59.69  E-value: 2.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   9 RGKAKTVY-----STENPDLLVLEFRNDTSAGDGARI-EQFDRKGMVNNKFNHFIMTKLQEAGIPTQMERLLSD------ 76
Cdd:PRK13959   1 MGSVKDFYvdeepTETDLGRGRFVFSDRYSVFDWGIMpDEIPDKGASLCTMGAYNFELLEEEGIKTHYIGVVEDgevvrl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  77 -------TECLVKKLE------------------------MVPVECVVRNR--AAGSLVKRLG----------------V 107
Cdd:PRK13959  81 aeaseppNEMAVKLTQvpdlpfeggsydydayheaagenyLIPLEVIFRNYvpVGSSLRDRIKegkikpedlgldadewP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 108 EEGIELNPPLFDLFLKNDAmHDPMINDSYCETFGWVSKENLARMKELTYKANDVLKKMFDDAGLILVDFKLEFGLY-KGE 186
Cdd:PRK13959 161 EEGVKLPEPIVEFSTKYEE-QDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYeERE 239

                        250
                 ....*....|....*
gi 489931768 187 VVLGDEF-SPDGSRL 200
Cdd:PRK13959 240 IRVVDVVgTFDENRF 254
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 8-201 8.36e-06

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 45.97  E-value: 8.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768   8 YRGKAKTVYSTENPDLLVLEFRNdtSAgdgarieqFDR-------KGMVNNKFNHFIMTKLQEAgIPTQMERLLSDTECL 80
Cdd:PLN02544  79 RRGKVRDIYDLGDYLVLVTTDRQ--SA--------FDRvlasipfKGQVLNQTSAWWFNNTKHI-TPNALVSSPDPNVTI 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768  81 VKKLEMVPVECVVRNRAAGSLVKRLGV--EEGIE--LNPPLFDLFLKNDAM-------------HDPMINDSYCETFGWV 143
Cdd:PLN02544 148 AKKCSVFPVEFVVRGYMTGSTSTSLWTvyNKGVRnyCGNDLPDGMVKNQKLpaniltpttkaadHDVPISPEEIVEEGLM 227

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489931768 144 SKENLarmKELTYKANDVLKKMFDDA---GLILVDFKLEFG-LYKGEVVLGDEF-SPDGSRLW 201
Cdd:PLN02544 228 TQEDF---DEVSSKALALFAFGQEVAaehGLILVDTKYEFGkDADGTILLIDEVhTPDSSRYW 287
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 106-218 6.77e-05

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 43.15  E-value: 6.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489931768 106 GVEEGIELNPPLFDLflkNDAMHDpmINDSYcETFGWVSKENLARMKELTYKANDVLKKMFDDAGLILVDFKLEFGLYKG 185
Cdd:PRK13960 176 GILTGIPGVPEADDV---NISRSD--IEANY-QAFNFSSADDIDLYEKLLKEGFKVISDALAKLDQIFVDTKFEFGYVTD 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489931768 186 -----EVVLGDEF-SPDGSRLWDKETLDK-----MDKDRFRQSL 218
Cdd:PRK13960 250 aagneKLIYMDEVgTPDSSRIWDGAAYRDgkiveNSKEGFRQFL 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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