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Conserved domains on  [gi|489943753|ref|WP_003847060|]
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MULTISPECIES: tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase TrmN [Citrobacter]

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.39e-84

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 251.60  E-value: 1.39e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   9 KRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQEN 88
Cdd:COG4123    2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  89 IAQSPWMHRVSVHTEDAQQWIPR-QTVRFDLIISNPPYYE--QGVECATPQREQARYTTSLDHQALLTLAADSITEDGFF 165
Cdd:COG4123   81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKagSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489943753 166 CVVLPEQIGNAFTQQALSIGWHLRLRTDVAETEARLPHRVLLAFSPQAGECFS--DRLVIRGPDQRYSEGYTALTQAF 241
Cdd:COG4123  161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.39e-84

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 251.60  E-value: 1.39e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   9 KRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQEN 88
Cdd:COG4123    2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  89 IAQSPWMHRVSVHTEDAQQWIPR-QTVRFDLIISNPPYYE--QGVECATPQREQARYTTSLDHQALLTLAADSITEDGFF 165
Cdd:COG4123   81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKagSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489943753 166 CVVLPEQIGNAFTQQALSIGWHLRLRTDVAETEARLPHRVLLAFSPQAGECFS--DRLVIRGPDQRYSEGYTALTQAF 241
Cdd:COG4123  161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 39-125 1.14e-15

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 74.47  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   39 WAPVAGVKRILDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQtvRFDL 118
Cdd:TIGR03533 116 WLEPEPVKRILDLCTGSGCIAIACAYAF-PEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR--KYDL 192


                  ....*..
gi 489943753  119 IISNPPY 125
Cdd:TIGR03533 193 IVSNPPY 199
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-125 9.99e-14

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 68.65  E-value: 9.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLLALMLAQ-RTDENVIidAVELDVDAAQQAQENIAQSPWmHRVSVHTEDAQQWIPRQtvRFDLIISNPP 124
Cdd:PRK09328 110 LRVLDLGTGSGAIALALAKeRPDAEVT--AVDISPEALAVARRNAKHGLG-ARVEFLQGDWFEPLPGG--RFDLIVSNPP 184


                 .
gi 489943753 125 Y 125
Cdd:PRK09328 185 Y 185
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-125 5.32e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 5.32e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQsPWMHRVSVHTEDAQQWIPRQTVRFDLIISNPPY 125
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVT--GVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-130 1.67e-10

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 57.99  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   46 KRILDIGTGSGLLALMLAQRTDEnVIIDAVELDVDAAQQAQENiAQSPWMHRVSVHTEDA-QQWIPRqtvRFDLIISNPP 124
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPD-AELTMVDINARALESAREN-LAANGLENGEVVASDVySGVEDG---KFDLIISNPP 107


                  ....*.
gi 489943753  125 YYEQGV 130
Cdd:pfam05175 108 FHAGLA 113
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-126 4.74e-06

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 45.58  E-value: 4.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753    48 ILDIGTGSGLLALMLAQRTDEnviIDAVELDVDAAQQAQENIAQSPwmhRVSVHTEDA-QQWIPRqtVRFDLIISNPPYY 126
Cdd:smart00650  17 VLEIGPGKGALTEELLERAKR---VTAIEIDPRLAPRLREKFAAAD---NLTVIHGDAlKFDLPK--LQPYKVVGNLPYN 88
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 9-241 1.39e-84

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 251.60  E-value: 1.39e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   9 KRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRILDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQEN 88
Cdd:COG4123    2 RLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  89 IAQSPWMHRVSVHTEDAQQWIPR-QTVRFDLIISNPPYYE--QGVECATPQREQARYTTSLDHQALLTLAADSITEDGFF 165
Cdd:COG4123   81 VALNGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKagSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489943753 166 CVVLPEQIGNAFTQQALSIGWHLRLRTDVAETEARLPHRVLLAFSPQAGECFS--DRLVIRGPDQRYSEGYTALTQAF 241
Cdd:COG4123  161 ALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRilPPLVIHDEDGEYTPEVKALLRDF 238
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 38-125 4.48e-16

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 75.57  E-value: 4.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  38 AWAPVAGVKRILDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQTvRFD 117
Cdd:COG2890  106 ALLPAGAPPRVLDLGTGSGAIALALAKER-PDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGDG-RFD 183


                 ....*...
gi 489943753 118 LIISNPPY 125
Cdd:COG2890  184 LIVSNPPY 191
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 39-125 1.14e-15

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 74.47  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   39 WAPVAGVKRILDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQtvRFDL 118
Cdd:TIGR03533 116 WLEPEPVKRILDLCTGSGCIAIACAYAF-PEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFAALPGR--KYDL 192


                  ....*..
gi 489943753  119 IISNPPY 125
Cdd:TIGR03533 193 IVSNPPY 199
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-125 9.99e-14

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 68.65  E-value: 9.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLLALMLAQ-RTDENVIidAVELDVDAAQQAQENIAQSPWmHRVSVHTEDAQQWIPRQtvRFDLIISNPP 124
Cdd:PRK09328 110 LRVLDLGTGSGAIALALAKeRPDAEVT--AVDISPEALAVARRNAKHGLG-ARVEFLQGDWFEPLPGG--RFDLIVSNPP 184


                 .
gi 489943753 125 Y 125
Cdd:PRK09328 185 Y 185
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 44-209 2.00e-13

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 68.15  E-value: 2.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   44 GVKRILDIGTGSGLLALMLAQrTDENVIIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAqqWIPRQTVRFDLIISNP 123
Cdd:TIGR00536 114 PILHILDLGTGSGCIALALAY-EFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNL--FEPLAGQKIDIIVSNP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  124 PYyeqgvecaTPQREQARYTTSLDHQALLTL----------------AADSITEDGFF-CVVLPEQIGNAFTQQALSIGW 186
Cdd:TIGR00536 191 PY--------IDEEDLADLPNVVRFEPLLALvggddglnilrqiielAPDYLKPNGFLvCEIGNWQQKSLKELLRIKFTW 262

                         170       180
                  ....*....|....*....|....
gi 489943753  187 H-LRLRTDVAETEarlphRVLLAF 209
Cdd:TIGR00536 263 YdVENGRDLNGKE-----RVVLGF 281
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 44-128 5.00e-13

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 65.21  E-value: 5.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  44 GVKRILDIGTGSGLLALMLAQRTDENVIIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQTV-RFDLII-- 120
Cdd:COG4122   16 GAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVLPRLADgPFDLVFid 95

                         90
                 ....*....|..
gi 489943753 121 ----SNPPYYEQ 128
Cdd:COG4122   96 adksNYPDYLEL 107
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-125 5.32e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 5.32e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQsPWMHRVSVHTEDAQQWIPRQTVRFDLIISNPPY 125
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVT--GVDISPVALELARKAAAA-LLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
46-121 1.05e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 62.36  E-value: 1.05e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489943753  46 KRILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQW-IPRqtvRFDLIIS 121
Cdd:COG4076   37 DVVLDIGTGSGLLSMLAARAGAKKVY--AVEVNPDIAAVARRIIAANGLSDRITVINADATDLdLPE---KADVIIS 108
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 41-125 1.65e-10

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 58.66  E-value: 1.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  41 PVAGVKRILDIGTGSGLLALMLAQRTDEnVIIDAVELDVDAAQQAQENiAQSPWMHRVSVHTEDAQQWIPRQtvRFDLII 120
Cdd:COG2813   46 PEPLGGRVLDLGCGYGVIGLALAKRNPE-ARVTLVDVNARAVELARAN-AAANGLENVEVLWSDGLSGVPDG--SFDLIL 121


                 ....*
gi 489943753 121 SNPPY 125
Cdd:COG2813  122 SNPPF 126
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-130 1.67e-10

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 57.99  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   46 KRILDIGTGSGLLALMLAQRTDEnVIIDAVELDVDAAQQAQENiAQSPWMHRVSVHTEDA-QQWIPRqtvRFDLIISNPP 124
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPD-AELTMVDINARALESAREN-LAANGLENGEVVASDVySGVEDG---KFDLIISNPP 107


                  ....*.
gi 489943753  125 YYEQGV 130
Cdd:pfam05175 108 FHAGLA 113
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-122 2.80e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 55.65  E-value: 2.80e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489943753   48 ILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQSPwmHRVSVHTEDAQQWiPRQTVRFDLIISN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVT--GVDLSPEMLERARERAAEAG--LNVEFVQGDAEDL-PFPDGSFDLVVSS 70
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-121 3.25e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.86  E-value: 3.25e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQtvRFDLIIS 121
Cdd:COG2230   54 RVLDIGCGWGGLALYLARRYGVRVT--GVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADG--QFDAIVS 124
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-122 3.99e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 52.52  E-value: 3.99e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIIdAVELDVDAAQQAQENIAqspwmhRVSVHTEDAQQWIPRQtvRFDLIISN 122
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERFPGARVT-GVDLSPEMLARARARLP------NVRFVVADLRDLDPPE--PFDLVVSN 70
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 38-124 8.37e-09

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 55.18  E-value: 8.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  38 AWAPVAGVKRILDIGTGSGLLALMLAQRTDEnVIidAVELDVDAAQQAQENIAQSPwMHRVSVHTEDAQQWIPRQTV--R 115
Cdd:COG2265  227 EWLDLTGGERVLDLYCGVGTFALPLARRAKK-VI--GVEIVPEAVEDARENARLNG-LKNVEFVAGDLEEVLPELLWggR 302


                 ....*....
gi 489943753 116 FDLIISNPP 124
Cdd:COG2265  303 PDVVVLDPP 311
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 27-131 1.21e-08

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 53.27  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   27 MKVGTD-GILLGAWAPVAGVKRILDIGTGSGLLALMLAQRTDENVIIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDA 105
Cdd:pfam01596  25 MQVSPDeGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDIDPEAYEIAKKFIQKAGVAHKISFILGPA 104

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 489943753  106 ----QQWIP-RQTVRFDLII------SNPPYYEQGVE 131
Cdd:pfam01596 105 lkvlEQLTQdKPLPEFDFIFidadksNYPNYYERLLE 141
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 46-122 1.38e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.94  E-value: 1.38e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489943753  46 KRILDIGTGSGLLALMLAQRTDEnviIDAVELDVDAAQQAQENIAQspwmHRVSVHTEDAQQwIPRQTVRFDLIISN 122
Cdd:COG2227   26 GRVLDVGCGTGRLALALARRGAD---VTGVDISPEALEIARERAAE----LNVDFVQGDLED-LPLEDGSFDLVICS 94
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-125 4.68e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 51.44  E-value: 4.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLLALMLAQRtDENVIidAVELDVDAAQQAQENIAQSPWMHR-VSVHTEDAQQwiPRQTVRFDLIISNPP 124
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKN-GKKVV--GVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFE--PFRGDKFDVILFNPP 99


                 .
gi 489943753 125 Y 125
Cdd:PRK14968 100 Y 100
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-122 7.16e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.07  E-value: 7.16e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQSPwMHRVSVHTEDAQQWIPRQTVRFDLIISN 122
Cdd:COG0500   29 RVLDLGCGTGRNLLALAARFGGRVI--GIDLSPEAIALARARAAKAG-LGNVEFLVADLAELDPLPAESFDLVVAF 101
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 35-122 1.17e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.61  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  35 LLGAWAPVAGvKRILDIGTGSGLLALMLAQRTDEnviIDAVELDVDAAQQAQENIAQSPWmhRVSVHTEDAQQwIPRQTV 114
Cdd:COG2226   14 LLAALGLRPG-ARVLDLGCGTGRLALALAERGAR---VTGVDISPEMLELARERAAEAGL--NVEFVVGDAED-LPFPDG 86


                 ....*...
gi 489943753 115 RFDLIISN 122
Cdd:COG2226   87 SFDLVISS 94
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
46-209 2.11e-07

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 49.83  E-value: 2.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLLALMLAqRTDENVIIDAVELD---VDAAQQ---AQENIAQSPwmhRVSVHTEDAQQWIPRQTVRFDLI 119
Cdd:COG0421   39 KRVLIIGGGDGGLARELL-KHPPVERVDVVEIDpevVELAREyfpLLAPAFDDP---RLRVVIGDGRAFLREAEESYDVI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753 120 ISNPPYYEQGVEcatpqreqaryttSLDHQALLTLAADSITEDGFFCVvlpeQIGNAFTQQALSIGWHLRLRtdvaeteA 199
Cdd:COG0421  115 IVDLTDPVGPAE-------------GLFTREFYEDCRRALKPGGVLVV----NLGSPFYGLDLLRRVLATLR-------E 170

                        170
                 ....*....|
gi 489943753 200 RLPHRVLLAF 209
Cdd:COG0421  171 VFPHVVLYAA 180
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
 40-124 4.24e-07

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 50.25  E-value: 4.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  40 APVAGVKRILDIGTGSGLLALMLAqRTDENVIIDAVELD---VDAAQQAQ------ENIAQSPwmhRVSVHTEDAQQWIP 110
Cdd:COG4262  282 AAHPRPRRVLVLGGGDGLAAREVL-KYPDVESVTLVDLDpevTDLAKTNPflrelnGGALNDP---RVTVVNADAFQFLR 357

                         90
                 ....*....|....
gi 489943753 111 RQTVRFDLIISNPP 124
Cdd:COG4262  358 ETDEKYDVIIVDLP 371
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
47-173 7.91e-07

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 49.18  E-value: 7.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIIDAVELDVDAAQQAQeniAQSPWM-HRVSVHTEDAQQWIPRQTVrfDLIISNPP- 124
Cdd:COG0827  118 RILDPAVGTGNLLTTVLNQLKKKVNAYGVEVDDLLIRLAA---VLANLQgHPVELFHQDALQPLLIDPV--DVVISDLPv 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489943753 125 -YYeqgvecatPQREQA-RYTTSLD------HQALLTLAADSITEDGFFCVVLPEQI 173
Cdd:COG0827  193 gYY--------PNDERAkRFKLKADeghsyaHHLFIEQSLNYLKPGGYLFFLVPSNL 241
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
46-122 1.01e-06

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 48.63  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLL---ALML-AQRtdenviIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQqwiprQTVRFDLIIS 121
Cdd:COG2264  150 KTVLDVGCGSGILaiaAAKLgAKR------VLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLL-----EDGPYDLVVA 218


                 .
gi 489943753 122 N 122
Cdd:COG2264  219 N 219
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
46-124 1.25e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 47.59  E-value: 1.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489943753  46 KRILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQspWMHRVSVHTEDAQQwiPRQTVRFDLIISNPP 124
Cdd:COG2263   47 KTVLDLGCGTGMLAIGAALLGAKKVV--GVDIDPEALEIARENAER--LGVRVDFIRADVTR--IPLGGSVDTVVMNPP 119
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 48-125 1.79e-06

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 48.32  E-value: 1.79e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489943753  48 ILDIGTGSGLLAL-MLAQRTDENVIidAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQtvRFDLIISNPPY 125
Cdd:PRK01544 142 ILELGTGSGCIAIsLLCELPNANVI--ATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFENIEKQ--KFDFIVSNPPY 216
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 47-140 2.20e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 46.62  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  47 RILDIGTGSGLLALMLAQRTDEnVIidAVELDVDAAQQAQENIAQSPWmHRVSVHTEDAQQWIPRQTvRFDLIIsnppyy 126
Cdd:COG2518   69 RVLEIGTGSGYQAAVLARLAGR-VY--SVERDPELAERARERLAALGY-DNVTVRVGDGALGWPEHA-PFDRII------ 137

                         90
                 ....*....|....
gi 489943753 127 eqgVECATPQREQA 140
Cdd:COG2518  138 ---VTAAAPEVPEA 148
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-208 3.35e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.14  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  38 AWAPVAGVKRILDIGTGSGLLALMLAQRTDEnviIDAVELDVDAAQQAQENIAQspwmhrVSVHTEDAQQWiPRQTVRFD 117
Cdd:COG4976   40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGYR---LTGVDLSEEMLAKAREKGVY------DRLLVADLADL-AEPDGRFD 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753 118 LIISNppyyeqGVECATPqreqaryttslDHQALLTLAADSITEDGFFCVVLPEQIGNAFTQQALSigwhlRLRTDVAET 197
Cdd:COG4976  110 LIVAA------DVLTYLG-----------DLAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD-----YVRDLLAAA 167

                        170
                 ....*....|.
gi 489943753 198 EARLPHRVLLA 208
Cdd:COG4976  168 GFEVPGLLVVA 178
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-126 4.74e-06

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 45.58  E-value: 4.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753    48 ILDIGTGSGLLALMLAQRTDEnviIDAVELDVDAAQQAQENIAQSPwmhRVSVHTEDA-QQWIPRqtVRFDLIISNPPYY 126
Cdd:smart00650  17 VLEIGPGKGALTEELLERAKR---VTAIEIDPRLAPRLREKFAAAD---NLTVIHGDAlKFDLPK--LQPYKVVGNLPYN 88
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
46-122 1.39e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 44.76  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLL---ALML-AQRtdenviIDAVELDVDAAQQAQENIAQSPwmhrVSVHTEdaqqwIPRQTVRFDLIIS 121
Cdd:PRK00517 121 KTVLDVGCGSGILaiaAAKLgAKK------VLAVDIDPQAVEAARENAELNG----VELNVY-----LPQGDLKADVIVA 185


                 .
gi 489943753 122 N 122
Cdd:PRK00517 186 N 186
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 32-127 1.72e-05

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 44.08  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   32 DGILLGAWAPVAGVKRILDIGTGSGLLALMLAQRTDEnviIDAVELDVDAAQQAQENIAQSPwmHRVSVHTEDAQQWIpr 111
Cdd:TIGR00537   7 DSLLLEANLRELKPDDVLEIGAGTGLVAIRLKGKGKC---ILTTDINPFAVKELRENAKLNN--VGLDVVMTDLFKGV-- 79

                          90
                  ....*....|....*.
gi 489943753  112 qTVRFDLIISNPPYYE 127
Cdd:TIGR00537  80 -RGKFDVILFNPPYLP 94
PRK14967 PRK14967
putative methyltransferase; Provisional
 47-125 2.86e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 43.89  E-value: 2.86e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489943753  47 RILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQSPwmHRVSVHTEDAQQWIPrqTVRFDLIISNPPY 125
Cdd:PRK14967  39 RVLDLCTGSGALAVAAAAAGAGSVT--AVDISRRAVRSARLNALLAG--VDVDVRRGDWARAVE--FRPFDVVVSNPPY 111
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-122 5.80e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.02  E-value: 5.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   46 KRILDIGTGSGLLALMLAQRTDENVIIDAVELDVDAAQQAQENIAQSPwMHRVSVHTEDA---QQWIPRQtvRFDLIISN 122
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLG-FDNVEFEQGDIeelPELLEDD--KFDVVISN 81
speE PRK01581
polyamine aminopropyltransferase;
46-165 7.85e-05

polyamine aminopropyltransferase;


Pssm-ID: 234961 [Multi-domain]  Cd Length: 374  Bit Score: 43.03  E-value: 7.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLlALMLAQRTDENVIIDAVELD---VDAAQQAQE--NIAQSPWM-HRVSVHTEDAQQWIPRQTVRFDLI 119
Cdd:PRK01581 152 KRVLILGGGDGL-ALREVLKYETVLHVDLVDLDgsmINMARNVPElvSLNKSAFFdNRVNVHVCDAKEFLSSPSSLYDVI 230

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489943753 120 ISNPPyyeqgvecaTPQRE--QARYTTSldhqaLLTLAADSITEDGFF 165
Cdd:PRK01581 231 IIDFP---------DPATEllSTLYTSE-----LFARIATFLTEDGAF 264
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 46-122 8.38e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 42.64  E-value: 8.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   46 KRILDIGTGSGLL---ALML-AQRtdenviIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPrqtvrFDLIIS 121
Cdd:pfam06325 163 ESVLDVGCGSGILaiaALKLgAKK------VVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEK-----ADVVVA 231


                  .
gi 489943753  122 N 122
Cdd:pfam06325 232 N 232
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 46-131 8.74e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 41.99  E-value: 8.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  46 KRILDIGTGSGLLAL-ML---AQRtdenviIDAVELDVDAAQQAQENIAQSPWMHRVSVHTEDAQQWIPRQT-VRFDLII 120
Cdd:COG0742   43 ARVLDLFAGSGALGLeALsrgAAS------VVFVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRFLKRLAgEPFDLVF 116

                         90
                 ....*....|.
gi 489943753 121 SNPPYYEQGVE 131
Cdd:COG0742  117 LDPPYAKGLLE 127
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
39-131 1.23e-04

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 41.46  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   39 WAPVAGVKRILDIGTGSGLLALMLAQRTDENVIidAVELDVDAAQQAQENIAQSPWMHRVSVHTeDAQQWI--PRQTVRF 116
Cdd:pfam03602  36 LAPYIEGARVLDLFAGSGALGLEALSRGAKRVT--LVEKDKRAVQILKENLQLLGLPGAVLVMD-ALLALLrlAGKGPVF 112

                          90
                  ....*....|....*
gi 489943753  117 DLIISNPPYYEQGVE 131
Cdd:pfam03602 113 DIVFLDPPYAKGLIE 127
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 37-184 1.34e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.47  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  37 GAWAP--------VAGVK---RILD--IGTGSGLL-ALMLAqrtdenviIDAVELDVD--AAQQAQENIAqspWMHR--V 98
Cdd:COG1041    8 GSLDPrlaralvnLAGAKegdTVLDpfCGTGTILIeAGLLG--------RRVIGSDIDpkMVEGARENLE---HYGYedA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  99 SVHTEDAQQwIPRQTVRFDLIISNPPYyeqgvecatpqreqARYTTSLDHQaLLTLAADSITE-------DGFFCVVLPE 171
Cdd:COG1041   77 DVIRGDARD-LPLADESVDAIVTDPPY--------------GRSSKISGEE-LLELYEKALEEaarvlkpGGRVVIVTPR 140

                        170
                 ....*....|...
gi 489943753 172 QIGNAFTQQALSI 184
Cdd:COG1041  141 DIDELLEEAGFKV 153
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 46-120 6.43e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 39.76  E-value: 6.43e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489943753  46 KRILDIGTGSGLLALMLAQRTDENVIIDAVELDVDAAQQAQENIAQspWM--HRVSVHTEDAQQWIPRQTvrFDLII 120
Cdd:COG2519   93 ARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER--FGlpDNVELKLGDIREGIDEGD--VDAVF 165
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 43-125 7.82e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 39.26  E-value: 7.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753   43 AGVK---RILDIGTGSGLL----ALMLAQR----TDENVIIDAVELDVDAA--QQAQENIAQSPWMHRVSVHTEDAQQwI 109
Cdd:pfam01170  24 AGWKpgdPLLDPMCGSGTIlieaALMGANIapgkFDARVRAPLYGSDIDRRmvQGARLNAENAGVGDLIEFVQADAAD-L 102

                          90
                  ....*....|....*.
gi 489943753  110 PRQTVRFDLIISNPPY 125
Cdd:pfam01170 103 PLLEGSVDVIVTNPPY 118
PRK03612 PRK03612
polyamine aminopropyltransferase;
38-124 1.32e-03

polyamine aminopropyltransferase;


Pssm-ID: 235139 [Multi-domain]  Cd Length: 521  Bit Score: 39.44  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  38 AWAPVAGVKRILDIGTGSGLlAL--MLAQRTDENViiDAVELD---VDAAQQAQ------ENIAQSPwmhRVSVHTEDAQ 106
Cdd:PRK03612 291 AMAASARPRRVLVLGGGDGL-ALreVLKYPDVEQV--TLVDLDpamTELARTSPalralnGGALDDP---RVTVVNDDAF 364

                         90
                 ....*....|....*...
gi 489943753 107 QWIPRQTVRFDLIISNPP 124
Cdd:PRK03612 365 NWLRKLAEKFDVIIVDLP 382
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-122 6.91e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.04  E-value: 6.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489943753   49 LDIGTGSGLLALMLAQRTdENVIIDAVELDVDAAQQAQENIAQSPWmHRVSVHTEDAQQWIPRQTVRFDLIISN 122
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL-PGLEYTGLDISPAALEAARERLAALGL-LNAVRVELFQLDLGELDPGSFDVVVAS 72
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 47-129 7.48e-03

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 36.98  E-value: 7.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489943753  47 RILDIGTGSGLLALMLA-QRTDenVIIDAVELDVDAAQQAQENIAQspwmhrVSVHTEDAQ-QW----IPRQTvRFDLII 120
Cdd:PRK14966 254 RVWDLGTGSGAVAVTVAlERPD--AFVRASDISPPALETARKNAAD------LGARVEFAHgSWfdtdMPSEG-KWDIIV 324


                 ....*....
gi 489943753 121 SNPPYYEQG 129
Cdd:PRK14966 325 SNPPYIENG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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