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Conserved domains on  [gi|489956626|ref|WP_003859933|]
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MULTISPECIES: long-chain-fatty-acid--CoA ligase FadD [Enterobacter]

Protein Classification

long-chain fatty acid--CoA ligase( domain architecture ID 11483486)

long-chain fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction; the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
1-560 0e+00

long-chain-fatty-acid--CoA ligase FadD;


:

Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 1246.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   1 MKKVWLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALM 80
Cdd:PRK08974   1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAK 160
Cdd:PRK08974  81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 161 GTLVNFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNA 240
Cdd:PRK08974 161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 241 TYGPLLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974 241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 321 QLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVP 400
Cdd:PRK08974 321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 401 HGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:PRK08974 401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 481 LEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
Cdd:PRK08974 481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
 
Name Accession Description Interval E-value
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
1-560 0e+00

long-chain-fatty-acid--CoA ligase FadD;


Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 1246.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   1 MKKVWLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALM 80
Cdd:PRK08974   1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAK 160
Cdd:PRK08974  81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 161 GTLVNFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNA 240
Cdd:PRK08974 161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 241 TYGPLLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974 241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 321 QLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVP 400
Cdd:PRK08974 321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 401 HGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:PRK08974 401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 481 LEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
Cdd:PRK08974 481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
FC-FACS_FadD_like cd05936
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...
25-550 0e+00

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341259 [Multi-domain]  Cd Length: 468  Bit Score: 718.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  25 LIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:cd05936    1 LADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQN-LGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdAI 184
Cdd:cd05936   80 NPLYTPRELEHILNDSGAKALIV-------------------------------------------------------AV 104
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 185 SFRRALHAGYRMQYvKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLlHPGKELVITALPLYHIFA 264
Cdd:cd05936  105 SFTDLLAAGAPLGE-RVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLEDL-LEGDDVVLAALPLFHVFG 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LTMNCLLFIELGGQNVLITNPRDIpGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAER 344
Cdd:cd05936  183 LTVALLLPLALGATIVLIPRFRPI-GVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSLRLCISGGAPLPVEVAER 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDA 424
Cdd:cd05936  262 FEELTGVPIVEGYGLTETSPVVAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEE 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 425 TDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKK 504
Cdd:cd05936  342 TAEAFVDGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVVLK 421
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 489956626 505 D-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05936  422 EgASLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
25-556 0e+00

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 574.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  25 LIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:COG0318    1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRA-LGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdai 184
Cdd:COG0318   80 NPRLTAEELAYILEDSGARALVT--------------------------------------------------------- 102
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 185 sfrralhagyrmqyvkpeivsedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGkELVITALPLYHIFA 264
Cdd:COG0318  103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALG--LTPG-DVVLVALPLFHVFG 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LTMNCLLFIELGGQNVLITNpRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAER 344
Cdd:COG0318  156 LTVGLLAPLLAGATLVLLPR-FDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLER 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDY-HSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPD 423
Cdd:COG0318  235 FEERFGVRIVEGYGLTETSPVVTVNPEDPGErRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPE 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 424 ATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVK 503
Cdd:COG0318  315 ATAEAFRDGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVL 394
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489956626 504 KD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAK 556
Cdd:COG0318  395 RPgAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYAAG 448
AMP-binding pfam00501
AMP-binding enzyme;
29-461 3.97e-139

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 409.39  E-value: 3.97e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   29 FEHSVRRYADQPAFVNM-GEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:pfam00501   1 LERQAARTPDKTALEVGeGRRLTYRELDERANRLAAGLRA-LGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  108 YTPRELEHQLNDSGAAAIVIVSNFahTLEKVVEKTQ-VKHVILTRMGDQLSTAKGTLVNFVVKYVKRLVPKYHLPDAisf 186
Cdd:pfam00501  80 LPAEELAYILEDSGAKVLITDDAL--KLEELLEALGkLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  187 rralhagyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVI-TALPLYHIFAL 265
Cdd:pfam00501 155 -------------------DDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVlSTLPLFHDFGL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  266 TMNCLLFIELGGQNVLI--TNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAE 343
Cdd:pfam00501 216 SLGLLGPLLAGATVVLPpgFPALDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELAR 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS--GSIGLPVPSTEAKLVDDED-NEVPHGEPGELCVRGPQVMLGYWQ 420
Cdd:pfam00501 296 RFRELFGGALVNGYGLTETTGVVTTPLPLDEDLRslGSVGRPLPGTEVKIVDDETgEPVPPGEPGELCVRGPGVMKGYLN 375
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 489956626  421 RPDATDE-IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:pfam00501 376 DPELTAEaFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
benz_CoA_lig TIGR02262
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ...
21-551 3.08e-68

benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.


Pssm-ID: 274059 [Multi-domain]  Cd Length: 505  Bit Score: 228.95  E-value: 3.08e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   21 RYQSLIELFEHSVRR-YADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:TIGR02262   2 KYNAAEDLLDRNVVEgRGGKTAFIDDISSLSYGELEAQVRRLAAALRR-LGVKREERVLLLMLDGVDFPIAFLGAIRAGI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKT-QVKHVILTrmGDQLSTAKgTLVNFVVKYVKRLVPKY 178
Cdd:TIGR02262  81 VPVALNTLLTADDYAYMLEDSRARVVFVSGALLPVIKAALGKSpHLEHRVVV--GRPEAGEV-QLAELLATESEQFKPAA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  179 HLPDaisfrralhagyrmqyvkpeivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvnaTYG-PLLHPGK-ELVITA 256
Cdd:TIGR02262 158 TQAD------------------------DPAFWLYSSGSTGMPKGVVHTHSNPYWTAE----LYArNTLGIREdDVCFSA 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  257 LPLYHIFALTmNCLLFIELGGQNVLITNPRDIPGLV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGM 335
Cdd:TIGR02262 210 AKLFFAYGLG-NALTFPMSVGATTVLMGERPTPDAVfDRLRRHQPTIFYGVPTLYAAMLADPNLPSEDQVRLRLCTSAGE 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  336 PVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQV 414
Cdd:TIGR02262 289 ALPAEVGQRWQARFGVDIVDGIGSTEMLHIFLSNlPGDVRY--GTSGKPVPGYRLRLVGDGGQDVADGEPGELLISGPSS 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  415 MLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSG 494
Cdd:TIGR02262 367 ATMYWNNRAKSRDTFQGEWTRSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFEIESALIQHPAVLEAAVVGVADEDGL 446
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626  495 EAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:TIGR02262 447 IKPKAFVVlRPGQTALETELKEHVKDRLAPYKYPRWIVFVDDLPKTATGKIQRFKLRE 504
 
Name Accession Description Interval E-value
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
1-560 0e+00

long-chain-fatty-acid--CoA ligase FadD;


Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 1246.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   1 MKKVWLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALM 80
Cdd:PRK08974   1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAK 160
Cdd:PRK08974  81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 161 GTLVNFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNA 240
Cdd:PRK08974 161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 241 TYGPLLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974 241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 321 QLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVP 400
Cdd:PRK08974 321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 401 HGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:PRK08974 401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 481 LEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
Cdd:PRK08974 481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
PRK07059 PRK07059
Long-chain-fatty-acid--CoA ligase; Validated
1-552 0e+00

Long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235923 [Multi-domain]  Cd Length: 557  Bit Score: 900.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   1 MKKVWLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALM 80
Cdd:PRK07059   1 MEKIWLKSYPPGVPAEIDASQYPSLADLLEESFRQYADRPAFICMGKAITYGELDELSRALAAWLQ-SRGLAKGARVAIM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLStAK 160
Cdd:PRK07059  80 MPNVLQYPVAIAAVLRAGYVVVNVNPLYTPRELEHQLKDSGAEAIVVLENFATTVQQVLAKTAVKHVVVASMGDLLG-FK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 161 GTLVNFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNA 240
Cdd:PRK07059 159 GHIVNFVVRRVKKMVPAWSLPGHVRFNDALAEGARQTFKPVKLGPDDVAFLQYTGGTTGVSKGATLLHRNIVANVLQMEA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 241 TYGPLL----HPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNN 316
Cdd:PRK07059 239 WLQPAFekkpRPDQLNFVCALPLYHIFALTVCGLLGMRTGGRNILIPNPRDIPGFIKELKKYQVHIFPAVNTLYNALLNN 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 317 KEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDED 396
Cdd:PRK07059 319 PDFDKLDFSKLIVANGGGMAVQRPVAERWLEMTGCPITEGYGLSETSPVATCNPVDATEFSGTIGLPLPSTEVSIRDDDG 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 397 NEVPHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK07059 399 NDLPLGEPGEICIRGPQVMAGYWNRPDETAKVMtADGFFRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVA 478
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 476 QHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07059 479 SHPGVLEVAAVGVPDEHSGEAVKLFVVKKDPALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRRELRDG 555
PRK05677 PRK05677
long-chain-fatty-acid--CoA ligase; Validated
5-560 0e+00

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 168170 [Multi-domain]  Cd Length: 562  Bit Score: 819.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   5 WLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNL 84
Cdd:PRK05677   6 WKDKYPAGIAAEINPDEYPNIQAVLKQSCQRFADKPAFSNLGKTLTYGELYKLSGAFAAWLQQHTDLKPGDRIAVQLPNV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLV 164
Cdd:PRK05677  86 LQYPVAVFGAMRAGLIVVNTNPLYTAREMEHQFNDSGAKALVCLANMAHLAEKVLPKTGVKHVIVTEVADMLPPLKRLLI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 165 NFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGP 244
Cdd:PRK05677 166 NAVVKHVKKMVPAYHLPQAVKFNDALAKGAGQPVTEANPQADDVAVLQYTGGTTGVAKGAMLTHRNLVANMLQCRALMGS 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 245 LLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF 324
Cdd:PRK05677 246 NLNEGCEILIAPLPLYHIYAFTFHCMAMMLIGNHNILISNPRDLPAMVKELGKWKFSGFVGLNTLFVALCNNEAFRKLDF 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 325 STLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEP 404
Cdd:PRK05677 326 SALKLTLSGGMALQLATAERWKEVTGCAICEGYGMTETSPVVSVNPSQ-AIQVGTIGIPVPSTLCKVIDDDGNELPLGEV 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 405 GELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEV 483
Cdd:PRK05677 405 GELCVKGPQVMKGYWQRPEATDEILdSDGWLKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQC 484
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 484 AAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
Cdd:PRK05677 485 AAIGVPDEKSGEAIKVFVVvKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRRELRDEELKKAGLK 562
PRK08751 PRK08751
long-chain fatty acid--CoA ligase;
5-555 0e+00

long-chain fatty acid--CoA ligase;


Pssm-ID: 181546 [Multi-domain]  Cd Length: 560  Bit Score: 774.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   5 WLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNL 84
Cdd:PRK08751   7 WLQSYPAGVAAEIDLEQFRTVAEVFATSVAKFADRPAYHSFGKTITYREADQLVEQFAAYLLGELQLKKGDRVALMMPNC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLV 164
Cdd:PRK08751  87 LQYPIATFGVLRAGLTVVNVNPLYTPRELKHQLIDSGASVLVVIDNFGTTVQQVIADTPVKQVITTGLGDMLGFPKAALV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 165 NFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVN---AT 241
Cdd:PRK08751 167 NFVVKYVKKLVPEYRINGAIRFREALALGRKHSMPTLQIEPDDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHqwlAG 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 242 YGPLLhPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:PRK08751 247 TGKLE-EGCEVVITALPLYHIFALTANGLVFMKIGGCNHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQ 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 322 LDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPH 401
Cdd:PRK08751 326 IDFSSLKMTLGGGMAVQRSVAERWKQVTGLTLVEAYGLTETSPAACINPLTLKEYNGSIGLPIPSTDACIKDDAGTVLAI 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 402 GEPGELCVRGPQVMLGYWQRPDATDEIIK-DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:PRK08751 406 GEIGELCIKGPQVMKGYWKRPEETAKVMDaDGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGV 485
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489956626 481 LEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARA 555
Cdd:PRK08751 486 LEVAAVGVPDEKSGEIVKVVIVKKDPALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRDAAKA 560
PRK12492 PRK12492
long-chain-fatty-acid--CoA ligase; Provisional
5-553 0e+00

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 171539 [Multi-domain]  Cd Length: 562  Bit Score: 735.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   5 WLNRYPADVPAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNL 84
Cdd:PRK12492   6 WNDKRPAGVPSTIDLAAYKSVVEVFERSCKKFADRPAFSNLGVTLSYAELERHSAAFAAYLQQHTDLVPGDRIAVQMPNV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLV 164
Cdd:PRK12492  86 LQYPIAVFGALRAGLIVVNTNPLYTAREMRHQFKDSGARALVYLNMFGKLVQEVLPDTGIEYLIEAKMGDLLPAAKGWLV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 165 NFVVKYVKRLVPKYHLPDAISFRRALHAGyRMQYVKPEIVS-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYG 243
Cdd:PRK12492 166 NTVVDKVKKMVPAYHLPQAVPFKQALRQG-RGLSLKPVPVGlDDIAVLQYTGGTTGLAKGAMLTHGNLVANMLQVRACLS 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 244 -------PLLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNN 316
Cdd:PRK12492 245 qlgpdgqPLMKEGQEVMIAPLPLYHIYAFTANCMCMMVSGNHNVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDH 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 317 KEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDED 396
Cdd:PRK12492 325 PGFKDLDFSALKLTNSGGTALVKATAERWEQLTGCTIVEGYGLTETSPVASTNPYGELARLGTVGIPVPGTALKVIDDDG 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 397 NEVPHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK12492 405 NELPLGERGELCIKGPQVMKGYWQQPEATAEALdAEGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVM 484
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 476 QHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK12492 485 AHPKVANCAAIGVPDERSGEAVKLFVVARDPGLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDIA 562
FC-FACS_FadD_like cd05936
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...
25-550 0e+00

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341259 [Multi-domain]  Cd Length: 468  Bit Score: 718.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  25 LIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:cd05936    1 LADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQN-LGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdAI 184
Cdd:cd05936   80 NPLYTPRELEHILNDSGAKALIV-------------------------------------------------------AV 104
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 185 SFRRALHAGYRMQYvKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLlHPGKELVITALPLYHIFA 264
Cdd:cd05936  105 SFTDLLAAGAPLGE-RVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLEDL-LEGDDVVLAALPLFHVFG 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LTMNCLLFIELGGQNVLITNPRDIpGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAER 344
Cdd:cd05936  183 LTVALLLPLALGATIVLIPRFRPI-GVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSLRLCISGGAPLPVEVAER 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDA 424
Cdd:cd05936  262 FEELTGVPIVEGYGLTETSPVVAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEE 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 425 TDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKK 504
Cdd:cd05936  342 TAEAFVDGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVVLK 421
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 489956626 505 D-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05936  422 EgASLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
25-556 0e+00

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 574.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  25 LIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:COG0318    1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRA-LGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdai 184
Cdd:COG0318   80 NPRLTAEELAYILEDSGARALVT--------------------------------------------------------- 102
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 185 sfrralhagyrmqyvkpeivsedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGkELVITALPLYHIFA 264
Cdd:COG0318  103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALG--LTPG-DVVLVALPLFHVFG 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LTMNCLLFIELGGQNVLITNpRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAER 344
Cdd:COG0318  156 LTVGLLAPLLAGATLVLLPR-FDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLER 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDY-HSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPD 423
Cdd:COG0318  235 FEERFGVRIVEGYGLTETSPVVTVNPEDPGErRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPE 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 424 ATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVK 503
Cdd:COG0318  315 ATAEAFRDGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVL 394
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489956626 504 KD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAK 556
Cdd:COG0318  395 RPgAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYAAG 448
PRK05605 PRK05605
long-chain-fatty-acid--CoA ligase; Validated
3-552 1.82e-171

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235531 [Multi-domain]  Cd Length: 573  Bit Score: 497.60  E-value: 1.82e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   3 KVWLNRYPADVPAEINPDRyQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMP 82
Cdd:PRK05605  13 KPWLQSYAPWTPHDLDYGD-TTLVDLYDNAVARFGDRPALDFFGATTTYAELGKQVRRAAAGLRA-LGVRPGDRVAIVLP 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  83 NLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGT 162
Cdd:PRK05605  91 NCPQHIVAFYAVLRLGAVVVEHNPLYTAHELEHPFEDHGARVAIVWDKVAPTVERLRRTTPLETIVSVNMIAAMPLLQRL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 163 LVNFVVKYVKRLVPKYH--LPDAISFRRALHA---GYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ 237
Cdd:PRK05605 171 ALRLPIPALRKARAALTgpAPGTVPWETLVDAaigGDGSDVSHPRPTPDDVALILYTSGTTGKPKGAQLTHRNLFANAAQ 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 238 VNAtYGPLLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITNPrDIPGLVKELAKYPFTAMTGVNTLFNALLNNK 317
Cdd:PRK05605 251 GKA-WVPGLGDGPERVLAALPMFHAYGLTLCLTLAVSIGGELVLLPAP-DIDLILDAMKKHPPTWLPGVPPLYEKIAEAA 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 318 EFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDED- 396
Cdd:PRK05605 329 EERGVDLSGVRNAFSGAMALPVSTVELWEKLTGGLLVEGYGLTETSPIIVGNPMSDDRRPGYVGVPFPDTEVRIVDPEDp 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 397 -NEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK05605 409 dETMPDGEEGELLVRGPQVFKGYWNRPEETAKSFLDGWFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVLR 488
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 476 QHSGVLEVAAVGVPSGSSGEAVKIFVVKKD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK05605 489 EHPGVEDAAVVGLPREDGSEEVVAAVVLEPgAALDPEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRRREVREE 566
PRK07656 PRK07656
long-chain-fatty-acid--CoA ligase; Validated
23-552 2.22e-153

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236072 [Multi-domain]  Cd Length: 513  Bit Score: 449.35  E-value: 2.22e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK07656   5 MTLPELLARAARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAA-LGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKT-QVKHVILTRMGDqlstakgtlvnfvvkyvkrlvPKYHLP 181
Cdd:PRK07656  84 PLNTRYTADEAAYILARGDAKALFVLGLFLGVDYSATTRLpALEHVVICETEE---------------------DDPHTE 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 182 DAISFRRALHAGYRmQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVnATYGPLlhPGKELVITALPLYH 261
Cdd:PRK07656 143 KMKTFTDFLAAGDP-AERAPEVDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADW-AEYLGL--TEGDRYLAANPFFH 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 262 IFALT--MN-CLLfielGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG--MP 336
Cdd:PRK07656 219 VFGYKagVNaPLM----RGATILPLPVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAasMP 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 337 VqqAVAERWVKLTG-QYLLEGYGLTECAPLVSVNPHDID--YHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQ 413
Cdd:PRK07656 295 V--ALLERFESELGvDIVLTGYGLSEASGVTTFNRLDDDrkTVAGTIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPN 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 414 VMLGYWQRPDATDEIIK-DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGS 492
Cdd:PRK07656 373 VMKGYYDDPEATAAAIDaDGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDER 452
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 493 SGEAVKIFVVKKDPS-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07656 453 LGEVGKAYVVLKPGAeLTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALREK 513
PRK06187 PRK06187
long-chain-fatty-acid--CoA ligase; Validated
20-551 7.67e-148

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235730 [Multi-domain]  Cd Length: 521  Bit Score: 435.38  E-value: 7.67e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  20 DRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:PRK06187   3 DYPLTIGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRA-LGVKKGDRVAVFDWNSHEYLEAYFAVPKIGA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQ-VKHVILtrMGDqlsTAKGTLVNFVVKYVkrlvpky 178
Cdd:PRK06187  82 VLHPINIRLKPEEIAYILNDAEDRVVLVDSEFVPLLAAILPQLPtVRTVIV--EGD---GPAAPLAPEVGEYE------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 179 hlpdaisfrrALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNAtyGPLLHPgKELVITALP 258
Cdd:PRK06187 150 ----------ELLAAASDTFDFPDIDENDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCA--WLKLSR-DDVYLVIVP 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 259 LYHIFALTMnCLLFIELGGQNVLItnPRDIPGLVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPV 337
Cdd:PRK06187 217 MFHVHAWGL-PYLALMAGAKQVIP--RRFDPENLLDLiETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYGGAAL 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 338 QQAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDIDY--HSGSIGLPVPSTEAKLVDDEDNEVPH--GEPGELCVR 410
Cdd:PRK06187 294 PPALLREFKEKFGIDLVQGYGMTETSPVVSVLPpedQLPGQwtKRRSAGRPLPGVEARIVDDDGDELPPdgGEVGEIIVR 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 411 GPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPS 490
Cdd:PRK06187 374 GPWLMQGYWNRPEATAETIDGGWLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVPD 453
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489956626 491 GSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK06187 454 EKWGERPVAVVVlKPGATLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLRE 515
PRK06710 PRK06710
long-chain-fatty-acid--CoA ligase; Validated
1-560 8.25e-146

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 180666 [Multi-domain]  Cd Length: 563  Bit Score: 431.76  E-value: 8.25e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   1 MKKVWLNRYPADVPAEINPDrYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALM 80
Cdd:PRK06710   3 VEKPWLKSYPEEIPSTISYD-IQPLHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQK-LGVEKGDRVAIM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAK 160
Cdd:PRK06710  81 LPNCPQAVIGYYGTLLAGGIVVQTNPLYTERELEYQLHDSGAKVILCLDLVFPRVTNVQSATKIEHVIVTRIADFLPFPK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 161 GTLVNFVVKYVKRLVPKYHLPDAI----SFRRALHAGYRMQyVKPEivsEDLAFLQYTGGTTGVAKGAMLTHRNMLAN-L 235
Cdd:PRK06710 161 NLLYPFVQKKQSNLVVKVSESETIhlwnSVEKEVNTGVEVP-CDPE---NDLALLQYTGGTTGFPKGVMLTHKNLVSNtL 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 236 EQVNATYGplLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLItnPR-DIPGLVKELAKYPFTAMTGVNTLFNALL 314
Cdd:PRK06710 237 MGVQWLYN--CKEGEEVVLGVLPFFHVYGMTAVMNLSIMQGYKMVLI--PKfDMKMVFEAIKKHKVTLFPGAPTIYIALL 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 315 NNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDD 394
Cdd:PRK06710 313 NSPLLKEYDISSIRACISGSAPLPVEVQEKFETVTGGKLVEGYGLTESSPVTHSNFLWEKRVPGSIGVPWPDTEAMIMSL 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 395 EDNEV-PHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:PRK06710 393 ETGEAlPPGEIGEIVVKGPQIMKGYWNKPEETAAVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEV 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 474 VMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06710 473 LYEHEKVQEVVTIGVPDPYRGETVKAFVVlKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEE 552

                 ....*...
gi 489956626 553 ARAKVDNK 560
Cdd:PRK06710 553 EKRKNEDE 560
FACL_FadD13-like cd17631
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...
29-546 7.97e-144

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.


Pssm-ID: 341286 [Multi-domain]  Cd Length: 435  Bit Score: 422.02  E-value: 7.97e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  29 FEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLY 108
Cdd:cd17631    1 LRRRARRHPDRTALVFGGRSLTYAELDERVNRLAHALR-ALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 109 TPRELEHQLNDSGAAAIVivsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrr 188
Cdd:cd17631   80 TPPEVAYILADSGAKVLF-------------------------------------------------------------- 97
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 189 alhagyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllhPGKELVITALPLYHIFALTMN 268
Cdd:cd17631   98 -----------------DDLALLMYTSGTTGRPKGAMLTHRNLLWNAVNALAALDL---GPDDVLLVVAPLFHIGGLGVF 157
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 269 CLLFIELGGQNVLITNPRdiPGLVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWvK 347
Cdd:cd17631  158 TLPTLLRGGTVVILRKFD--PETVLDLiERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRAL-Q 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 348 LTGQYLLEGYGLTECAPLVSVNPH-DIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATD 426
Cdd:cd17631  235 ARGVKFVQGYGMTETSPGVTFLSPeDHRRKLGSAGRPVFFVEVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEATA 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 427 EIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDP 506
Cdd:cd17631  315 AAFRDGWFHTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVVPRPG 394
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 489956626 507 S-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17631  395 AeLDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435
AMP-binding pfam00501
AMP-binding enzyme;
29-461 3.97e-139

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 409.39  E-value: 3.97e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   29 FEHSVRRYADQPAFVNM-GEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:pfam00501   1 LERQAARTPDKTALEVGeGRRLTYRELDERANRLAAGLRA-LGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  108 YTPRELEHQLNDSGAAAIVIVSNFahTLEKVVEKTQ-VKHVILTRMGDQLSTAKGTLVNFVVKYVKRLVPKYHLPDAisf 186
Cdd:pfam00501  80 LPAEELAYILEDSGAKVLITDDAL--KLEELLEALGkLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  187 rralhagyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVI-TALPLYHIFAL 265
Cdd:pfam00501 155 -------------------DDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVlSTLPLFHDFGL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  266 TMNCLLFIELGGQNVLI--TNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAE 343
Cdd:pfam00501 216 SLGLLGPLLAGATVVLPpgFPALDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELAR 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS--GSIGLPVPSTEAKLVDDED-NEVPHGEPGELCVRGPQVMLGYWQ 420
Cdd:pfam00501 296 RFRELFGGALVNGYGLTETTGVVTTPLPLDEDLRslGSVGRPLPGTEVKIVDDETgEPVPPGEPGELCVRGPGVMKGYLN 375
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 489956626  421 RPDATDE-IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:pfam00501 376 DPELTAEaFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
PRK08314 PRK08314
long-chain-fatty-acid--CoA ligase; Validated
24-556 3.13e-133

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236235 [Multi-domain]  Cd Length: 546  Bit Score: 398.95  E-value: 3.13e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  24 SLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK08314  11 SLFHNLEVSARRYPDKTAIVFYGRAISYRELLEEAERLAGYLQQECGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVP 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 104 VNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLStAKGTLVNFVVKYVKRLVPKYHLPDA 183
Cdd:PRK08314  91 VNPMNREEELAHYVTDSGARVAIVGSELAPKVAPAVGNLRLRHVIVAQYSDYLP-AEPEIAVPAWLRAEPPLQALAPGGV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 184 ISFRRALHAGYRmqyvkPEIV---SEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqVNATYGPLLHPGkELVITALPLY 260
Cdd:PRK08314 170 VAWKEALAAGLA-----PPPHtagPDDLAVLPYTSGTTGVPKGCMHTHRTVMANA--VGSVLWSNSTPE-SVVLAVLPLF 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 261 HI--FALTMNCLLFieLGGQNVLITN-PRDIPGLVkeLAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPV 337
Cdd:PRK08314 242 HVtgMVHSMNAPIY--AGATVVLMPRwDREAAARL--IERYRVTHWTNIPTMVVDFLASPGLAERDLSSLRYIGGGGAAM 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 338 QQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLVDDED-NEVPHGEPGELCVRGPQVML 416
Cdd:PRK08314 318 PEAVAERLKELTGLDYVEGYGLTETMAQTHSNPPD-RPKLQCLGIPTFGVDARVIDPETlEELPPGEVGEIVVHGPQVFK 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 417 GYWQRPDATDE--IIKDG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGS 492
Cdd:PRK08314 397 GYWNRPEATAEafIEIDGkrFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACVIATPDPR 476
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 493 SGEAVKIFVVKKDPS---LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAK 556
Cdd:PRK08314 477 RGETVKAVVVLRPEArgkTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKILWRQLQEQEKAR 543
Firefly_Luc_like cd05911
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...
46-545 9.55e-133

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341237 [Multi-domain]  Cd Length: 486  Bit Score: 395.43  E-value: 9.55e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaI 125
Cdd:cd05911    8 GKELTYAQLRTLSRRLAAGLRK-LGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPK-V 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIVSNfaHTLEKVVEKTQ----VKHVILTRMGDQLSTAKGTLVNFVVKYVKRLVPKYhlpdaisfrralhagyrmqyvkP 201
Cdd:cd05911   86 IFTDP--DGLEKVKEAAKelgpKDKIIVLDDKPDGVLSIEDLLSPTLGEEDEDLPPP----------------------L 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 202 EIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPgKELVITALPLYHIFAL--TMNCLLFielgGQN 279
Cdd:cd05911  142 KDGKDDTAAILYSSGTTGLPKGVCLSHRNLIANLSQVQTFLYGNDGS-NDVILGFLPLYHIYGLftTLASLLN----GAT 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 280 VLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQ-YLLEGYG 358
Cdd:cd05911  217 VIIMPKFDSELFLDLIEKYKITFLYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNaTIKQGYG 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 359 LTECAPLVSVNPhDIDYHSGSIGLPVPSTEAKLVDDEDNE-VPHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHT 436
Cdd:cd05911  297 MTETGGILTVNP-DGDDKPGSVGRLLPNVEAKIVDDDGKDsLGPNEPGEICVRGPQVMKGYYNNPEATKETFdEDGWLHT 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 437 GDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD-PSLTEDALIT 515
Cdd:cd05911  376 GDIGYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPgEKLTEKEVKD 455
                        490       500       510
                 ....*....|....*....|....*....|...
gi 489956626 516 FCRRQLTGYKvpKL---VEFRDELPKSNVGKIL 545
Cdd:cd05911  456 YVAKKVASYK--QLrggVVFVDEIPKSASGKIL 486
PRK08316 PRK08316
acyl-CoA synthetase; Validated
14-552 2.89e-123

acyl-CoA synthetase; Validated


Pssm-ID: 181381 [Multi-domain]  Cd Length: 523  Bit Score: 372.73  E-value: 2.89e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  14 PAEINPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK08316   2 MERSTRARRQTIGDILRRSARRYPDKTALVFGDRSWTYAELDAAVNRVAAALL-DLGLKKGDRVAALGHNSDAYALLWLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  94 ILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLvnfvvkyvkr 173
Cdd:PRK08316  81 CARAGAVHVPVNFMLTGEELAYILDHSGARAFLVDPALAPTAEAALALLPVDTLILSLVLGGREAPGGWL---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 174 lvpkyhlpdaiSFRRALHAGYRMQyVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqvnatYGPLLHPGK--- 250
Cdd:PRK08316 151 -----------DFADWAEAGSVAE-PDVELADDDLAQILYTSGTESLPKGAMLTHRALIAE-------YVSCIVAGDmsa 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 251 -ELVITALPLYHIFALTMNCLLFIELGGQNVLITNPrDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL 329
Cdd:PRK08316 212 dDIPLHALPLYHCAQLDVFLGPYLYVGATNVILDAP-DPELILRTIEAERITSFFAPPTVWISLLRHPDFDTRDLSSLRK 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 330 SAGGG--MPVQ--QAVAERwvkLTGQYLLEGYGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEP 404
Cdd:PRK08316 291 GYYGAsiMPVEvlKELRER---LPGLRFYNCYGQTEIAPLATVlGPEEHLRRPGSAGRPVLNVETRVVDDDGNDVAPGEV 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 405 GELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVA 484
Cdd:PRK08316 368 GEIVHRSPQLMLGYWDDPEKTAEAFRGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVA 447
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 485 AVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK08316 448 VIGLPDPKWIEAVTAVVVpKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKRELRER 516
AFD_class_I cd04433
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...
207-545 5.19e-119

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341228 [Multi-domain]  Cd Length: 336  Bit Score: 355.05  E-value: 5.19e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllhPGKELVITALPLYHIFAltMNCLLFIELGGQNVLITNPR 286
Cdd:cd04433    1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGL---TEGDVFLSTLPLFHIGG--LFGLLGALLAGGTVVLLPKF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLV 366
Cdd:cd04433   76 DPEAALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIKLVNGYGLTETGGTV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 367 SVN-PHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDE 445
Cdd:cd04433  156 ATGpPDDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVDEDGWYRTGDLGRLDED 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 446 GFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPS-LTEDALITFCRRQLTGY 524
Cdd:cd04433  236 GYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGAdLDAEELRAHVRERLAPY 315
                        330       340
                 ....*....|....*....|.
gi 489956626 525 KVPKLVEFRDELPKSNVGKIL 545
Cdd:cd04433  316 KVPRRVVFVDALPRTASGKID 336
4CL cd05904
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...
33-549 7.75e-117

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.


Pssm-ID: 341230 [Multi-domain]  Cd Length: 505  Bit Score: 355.39  E-value: 7.75e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  33 VRRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTP 110
Cdd:cd05904   15 ASAHPSRPALIDaaTGRALTYAELERRVRRLAAGLAK-RGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTP 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 111 RELEHQLNDSGAAAIVIVSnfahtleKVVEKTQvkhviltrmgdqlstakgtlvNFVVKYVkrLVPKYHLpDAISFRRAL 190
Cdd:cd05904   94 AEIAKQVKDSGAKLAFTTA-------ELAEKLA---------------------SLALPVV--LLDSAEF-DSLSFSDLL 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 191 HAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGkELVITALPLYHIFALTMNCL 270
Cdd:cd05904  143 FEADEAEPPVVVIKQDDVAALLYSSGTTGRSKGVMLTHRNLIAMVAQFVAGEGSNSDSE-DVFLCVLPMFHIYGLSSFAL 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 271 LFIELGGQNVLItnPR-DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH-LSAGG---GMPVQQAVAER- 344
Cdd:cd05904  222 GLLRLGATVVVM--PRfDLEELLAAIERYKVTHLPVVPPIVLALVKSPIVDKYDLSSLRqIMSGAaplGKELIEAFRAKf 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 -WVKLtgqylLEGYGLTECAPLVSV--NPHDIDYHSGSIGLPVPSTEAKLVDDEDNEV-PHGEPGELCVRGPQVMLGYWQ 420
Cdd:cd05904  300 pNVDL-----GQGYGMTESTGVVAMcfAPEKDRAKYGSVGRLVPNVEAKIVDPETGESlPPNQTGELWIRGPSIMKGYLN 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 421 RPDATDE-IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKI 499
Cdd:cd05904  375 NPEATAAtIDKEGWLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMA 454
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489956626 500 FVVKK-DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05904  455 FVVRKpGSSLTEDEIMDFVAKQVAPYKKVRKVAFVDAIPKSPSGKILRKEL 505
PRK06178 PRK06178
acyl-CoA synthetase; Validated
5-553 1.11e-113

acyl-CoA synthetase; Validated


Pssm-ID: 235724 [Multi-domain]  Cd Length: 567  Bit Score: 349.34  E-value: 1.11e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   5 WLNRYPADVPAEIN-PDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLqEGLGLQKGDRVALMMPN 83
Cdd:PRK06178  14 QQAAWPAGIPREPEyPHGERPLTEYLRAWARERPQRPAIIFYGHVITYAELDELSDRFAALL-RQRGVGAGDRVAVFLPN 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  84 LLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTL 163
Cdd:PRK06178  93 CPQFHIVFFGILKLGAVHVPVSPLFREHELSYELNDAGAEVLLALDQLAPVVEQVRAETSLRHVIVTSLADVLPAEPTLP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 164 VNFVVKyvkrlVPKYHLPDAISFRRALHA-GYRMQYVKPEIvsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqvnATY 242
Cdd:PRK06178 173 LPDSLR-----APRLAAAGAIDLLPALRAcTAPVPLPPPAL--DALAALNYTGGTTGMPKGCEHTQRDMVYTA----AAA 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 243 GPLLHPGKE--LVITALPLYHIfALTMNCLLF-IELGGQNVLITnpR-DIPGLVKELAKYPFTAMTGVNTLFNALLNNKE 318
Cdd:PRK06178 242 YAVAVVGGEdsVFLSFLPEFWI-AGENFGLLFpLFSGATLVLLA--RwDAVAFMAAVERYRVTRTVMLVDNAVELMDHPR 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 319 FQQLDFSTL-HLSAGGGM-PVQQAVAERWVKLTGQYLLEG-YGLTE---CAPLVS-VNPHDIDYHSGSI--GLPVPSTEA 389
Cdd:PRK06178 319 FAEYDLSSLrQVRVVSFVkKLNPDYRQRWRALTGSVLAEAaWGMTEthtCDTFTAgFQDDDFDLLSQPVfvGLPVPGTEF 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 390 KLVDDEDNE-VPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PRK06178 399 KICDFETGElLPLGAEGEIVVRTPSLLKGYWNKPEATAEALRDGWLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPS 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 469 EIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKlVEFRDELPKSNVGKILRR 547
Cdd:PRK06178 479 EVEALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQlKPGADLTAAALQAWCRENMAVYKVPE-IRIVDALPMTATGKVRKQ 557

                 ....*.
gi 489956626 548 ELRDEA 553
Cdd:PRK06178 558 DLQALA 563
PRK08315 PRK08315
AMP-binding domain protein; Validated
27-553 1.04e-106

AMP-binding domain protein; Validated


Pssm-ID: 236236 [Multi-domain]  Cd Length: 559  Bit Score: 331.01  E-value: 1.04e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPA--FVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPN-----LLQYPVAlfgilRAGM 99
Cdd:PRK08315  20 QLLDRTAARYPDREAlvYRDQGLRWTYREFNEEVDALAKGLLA-LGIEKGDRVGIWAPNvpewvLTQFATA-----KIGA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtlekvveKTQVKHVILTRMGDQLSTAK-GTLVNFVVKYVKRLV--- 175
Cdd:PRK08315  94 ILVTINPAYRLSELEYALNQSGCKALIAADGF---------KDSDYVAMLYELAPELATCEpGQLQSARLPELRRVIflg 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 176 -PKYhlPDAISFRRALHAGYRMQYVKPEIVSEDLAF-----LQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPG 249
Cdd:PRK08315 165 dEKH--PGMLNFDELLALGRAVDDAELAARQATLDPddpinIQYTSGTTGFPKGATLTHRNILNNGYFIGEAMK--LTEE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 250 KELVITaLPLYHIFALTMNCLLFIELGGQNVLITNPRDiPGLV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH 328
Cdd:PRK08315 241 DRLCIP-VPLYHCFGMVLGNLACVTHGATMVYPGEGFD-PLATlAAVEEERCTALYGVPTMFIAELDHPDFARFDLSSLR 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 --LSAGGGMPVQqaVAERWVKLtgQYLLE---GYGLTECAPlVSV--NPHD-IDYHSGSIGLPVPSTEAKLVDDEDNE-V 399
Cdd:PRK08315 319 tgIMAGSPCPIE--VMKRVIDK--MHMSEvtiAYGMTETSP-VSTqtRTDDpLEKRVTTVGRALPHLEVKIVDPETGEtV 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 400 PHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHS 478
Cdd:PRK08315 394 PRGEQGELCTRGYSVMKGYWNDPEKTAEAIdADGWMHTGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLYTHP 473
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 479 GVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK08315 474 KIQDVQVVGVPDEKYGEEVCAWIIlRPGATLTEEDVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMREMM 549
LC_FACS_like cd05935
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...
49-549 1.06e-105

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.


Pssm-ID: 341258 [Multi-domain]  Cd Length: 430  Bit Score: 324.05  E-value: 1.06e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIV 128
Cdd:cd05935    2 LTYLELLEVVKKLASFLSN-KGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 129 SNFahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivsEDL 208
Cdd:cd05935   81 SEL--------------------------------------------------------------------------DDL 86
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 209 AFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGkELVITALPLYHIFALTMNCLLFIELGGQNVLITNpRDI 288
Cdd:cd05935   87 ALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTG--LTPS-DVILACLPLFHVTGFVGSLNTAVYVGGTYVLMAR-WDR 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 289 PGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSV 368
Cdd:cd05935  163 ETALELIEKYKVTFWTNIPTMLVDLLATPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGLRFVEGYGLTETMSQTHT 242
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 369 NPHdIDYHSGSIGLPVPSTEAKLVDDEDN-EVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKDG---WLHTGDIAVMD 443
Cdd:cd05935  243 NPP-LRPKLQCLGIP*FGVDARVIDIETGrELPPNEVGEIVVRGPQIFKGYWNRPEETEEsFIEIKgrrFFRTGDLGYMD 321
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDP---SLTEDALITFCRRQ 520
Cdd:cd05935  322 EEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLRPEyrgKVTEEDIIEWAREQ 401
                        490       500
                 ....*....|....*....|....*....
gi 489956626 521 LTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05935  402 MAAYKYPREVEFVDELPRSASGKILWRLL 430
Acs COG0365
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
27-556 1.89e-102

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];


Pssm-ID: 440134 [Multi-domain]  Cd Length: 565  Bit Score: 320.14  E-value: 1.89e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:COG0365   13 NCLDRHAEGRGDKVALIWEGEdgeerTLTYAELRREVNRFANALRA-LGVKKGDRVAIYLPNIPEAVIAMLACARIGAVH 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVIltrmgDQLSTAKGTLVnfvvkyVKRLVPKYHLP 181
Cdd:COG0365   92 SPVFPGFGAEALADRIEDAEAKVLITADGGLRGGKVIDLKEKVDEAL-----EELPSLEHVIV------VGRTGADVPME 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 182 DAISFRRALHAGyrMQYVKPEIV-SEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqvnATYGPL---LHPGkELVITAL 257
Cdd:COG0365  161 GDLDWDELLAAA--SAEFEPEPTdADDPLFILYTSGTTGKPKGVVHTHGGYLVHA----ATTAKYvldLKPG-DVFWCTA 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 258 PLYHIFALTmNCLLFIELGGQNVLI----TNPRDIPGLVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSA 331
Cdd:COG0365  234 DIGWATGHS-YIVYGPLLNGATVVLyegrPDFPDPGRLWELIEKYGVTVFFTAPTAIRALMKagDEPLKKYDLSSLRLLG 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 332 GGGMPVQQAVAERWVKLTGQYLLEGYGLTE-CAPLVSvNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVR 410
Cdd:COG0365  313 SAGEPLNPEVWEWWYEAVGVPIVDGWGQTEtGGIFIS-NLPGLPVKPGSMGKPVPGYDVAVVDEDGNPVPPGEEGELVIK 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 411 GPQ--VMLGYWQRPDATDEIIKD---GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAA 485
Cdd:COG0365  392 GPWpgMFRGYWNDPERYRETYFGrfpGWYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAVAEAAV 471
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489956626 486 VGVPSGSSGEAVKIFVV-KKDPSLTED---ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAK 556
Cdd:COG0365  472 VGVPDEIRGQVVKAFVVlKPGVEPSDElakELQAHVREELGPYAYPREIEFVDELPKTRSGKIMRRLLRKIAEGR 546
PRK06839 PRK06839
o-succinylbenzoate--CoA ligase;
30-554 6.78e-101

o-succinylbenzoate--CoA ligase;


Pssm-ID: 168698 [Multi-domain]  Cd Length: 496  Bit Score: 314.11  E-value: 6.78e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  30 EHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYT 109
Cdd:PRK06839   9 EKRAYLHPDRIAIITEEEEMTYKQLHEYVSKVAAYLIYELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRLT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 110 PRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVIltRMGDQLSTAKGTLVNFVVKyvkrlvpkyhlpdaisfrra 189
Cdd:PRK06839  89 ENELIFQLKDSGTTVLFVEKTFQNMALSMQKVSYVQRVI--SITSLKEIEDRKIDNFVEK-------------------- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 190 lhagyrmqyvkpeivSEDLAFLQ-YTGGTTGVAKGAMLTHRNMLANleQVNATYGPLLHpGKELVITALPLYHIFALTMN 268
Cdd:PRK06839 147 ---------------NESASFIIcYTSGTTGKPKGAVLTQENMFWN--ALNNTFAIDLT-MHDRSIVLLPLFHIGGIGLF 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 269 CLLFIELGGQnVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG----MPVQQAVAER 344
Cdd:PRK06839 209 AFPTLFAGGV-IIVPRKFEPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGapcpEELMREFIDR 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 wvkltGQYLLEGYGLTECAPLV-SVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPD 423
Cdd:PRK06839 288 -----GFLFGQGFGMTETSPTVfMLSEEDARRKVGSIGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPD 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 424 ATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVK 503
Cdd:PRK06839 363 ATEETIQDGWLCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVK 442
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489956626 504 KD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK06839 443 KSsSVLIEKDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVNQLK 494
PRK12583 PRK12583
acyl-CoA synthetase; Provisional
19-553 2.43e-98

acyl-CoA synthetase; Provisional


Pssm-ID: 237145 [Multi-domain]  Cd Length: 558  Bit Score: 309.40  E-value: 2.43e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  19 PDRYQSLIELFEHSVRRYADQPAFV--NMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK12583  14 PLLTQTIGDAFDATVARFPDREALVvrHQALRYTWRQLADAVDRLARGLL-ALGVQPGDRVGIWAPNCAEWLLTQFATAR 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtlekvveKTQVKHVILTRMGDQL-STAKGTLVN-------FVV 168
Cdd:PRK12583  93 IGAILVNINPAYRASELEYALGQSGVRWVICADAF---------KTSDYHAMLQELLPGLaEGQPGALACerlpelrGVV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 169 KYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHP 248
Cdd:PRK12583 164 SLAPAPPPGFLAWHELQARGETVSREALAERQASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLG--LTE 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 249 GKELVItALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH 328
Cdd:PRK12583 242 HDRLCV-PVPLYHCFGMVLANLGCMTVGACLVYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFDLSSLR 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 LSAGGGMPVQQAVAERWVK-LTGQYLLEGYGLTECAPLV--SVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPG 405
Cdd:PRK12583 321 TGIMAGAPCPIEVMRRVMDeMHMAEVQIAYGMTETSPVSlqTTAADDLERRVETVGRTQPHLEVKVVDPDGATVPRGEIG 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 406 ELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVA 484
Cdd:PRK12583 401 ELCTRGYSVMKGYWNNPEATAESIdEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVADVQ 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 485 AVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK12583 481 VFGVPDEKYGEEIVAWVRlHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREIS 550
PRK06188 PRK06188
acyl-CoA synthetase; Validated
27-550 3.40e-97

acyl-CoA synthetase; Validated


Pssm-ID: 235731 [Multi-domain]  Cd Length: 524  Bit Score: 305.37  E-value: 3.40e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEER-SRAFAAYlqEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:PRK06188  16 HLLVSALKRYPDRPALVLGDTRLTYGQLADRiSRYIQAF--EALGLGTGDAVALLSLNRPEVLMAIGAAQLAGLRRTALH 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 106 PLYTPRELEHQLNDSGAAAIVIVSNfahtleKVVEKTQVkhvILTRmgdqlstakgtlvnfvVKYVKRLVPKYHLPDAIS 185
Cdd:PRK06188  94 PLGSLDDHAYVLEDAGISTLIVDPA------PFVERALA---LLAR----------------VPSLKHVLTLGPVPDGVD 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 186 FRrALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPgKELVITalPLYHIFAL 265
Cdd:PRK06188 149 LL-AAAAKFGPAPLVAAALPPDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWEWPADP-RFLMCT--PLSHAGGA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 266 TMNCLLFieLGGQNVLIT--NPRDIPGLVKElakYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAE 343
Cdd:PRK06188 225 FFLPTLL--RGGTVIVLAkfDPAEVLRAIEE---QRITATFLVPTMIYALLDHPDLRTRDLSSLETVYYGASPMSPVRLA 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 344 RWVKLTGQYLLEGYGLTECAPLVSVNP---HDID--YHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGY 418
Cdd:PRK06188 300 EAIERFGPIFAQYYGQTEAPMVITYLRkrdHDPDdpKRLTSCGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGY 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 419 WQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVK 498
Cdd:PRK06188 380 WNRPEETAEAFRDGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGVPDEKWGEAVT 459
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489956626 499 IFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK06188 460 AVVVlRPGAAVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALR 512
FACL_DitJ_like cd05934
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
50-550 4.99e-97

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.


Pssm-ID: 341257 [Multi-domain]  Cd Length: 422  Bit Score: 301.52  E-value: 4.99e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIvs 129
Cdd:cd05934    5 TYAELLRESARIAAALAA-LGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVVV-- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 nfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivseDLA 209
Cdd:cd05934   82 -----------------------------------------------------------------------------DPA 84
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 210 FLQYTGGTTGVAKGAMLTHRNMLaNLEQVNATYGPLlhPGKELVITALPLYHIFALTMNCLLFIELGGQNVLItnPRDIP 289
Cdd:cd05934   85 SILYTSGTTGPPKGVVITHANLT-FAGYYSARRFGL--GEDDVYLTVLPLFHINAQAVSVLAALSVGATLVLL--PRFSA 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 290 -GLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQ--QAVAERWvkltGQYLLEGYGLTEcAPLV 366
Cdd:cd05934  160 sRFWSDVRRYGATVTNYLGAMLSYLLAQPPSPDDRAHRLRAAYGAPNPPElhEEFEERF----GVRLLEGYGMTE-TIVG 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 367 SVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVR---GPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMD 443
Cdd:cd05934  235 VIGPRDEPRRPGSIGRPAPGYEVRIVDDDGQELPAGEPGELVIRglrGWGFFKGYYNMPEATAEAMRNGWFHTGDLGYRD 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDP-SLTEDALITFCRRQLT 522
Cdd:cd05934  315 ADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGeTLDPEELFAFCEGQLA 394
                        490       500
                 ....*....|....*....|....*...
gi 489956626 523 GYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05934  395 YFKVPRYIRFVDDLPKTPTEKVAKAQLR 422
BCL_4HBCL cd05959
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...
20-550 6.32e-95

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.


Pssm-ID: 341269 [Multi-domain]  Cd Length: 508  Bit Score: 298.90  E-value: 6.32e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  20 DRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:cd05959    1 EKYNAATLVDLNLNEGRGDKTAFIDDAGSLTYAELEAEARRVAGALRA-LGVKREERVLLIMLDTVDFPTAFLGAIRAGI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEK--TQVKHVILTRmGDQLSTAKGTLVNFVVKYVKRLVPK 177
Cdd:cd05959   80 VPVPVNTLLTPDDYAYYLEDSRARVVVVSGELAPVLAAALTKseHTLVVLIVSG-GAGPEAGALLLAELVAAEAEQLKPA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 178 yhlpdaisfrrALHAgyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvnaTYG-PLLHPGK-ELVIT 255
Cdd:cd05959  159 -----------ATHA-------------DDPAFWLYSSGSTGRPKGVVHLHADIYWTAE----LYArNVLGIREdDVCFS 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 256 ALPLYHIFALTmNCLLFIELGGQNVLITNPRDIPGLV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:cd05959  211 AAKLFFAYGLG-NSLTFPLSVGATTVLMPERPTPAAVfKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLCVSAG 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 335 MPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQ 413
Cdd:cd05959  290 EALPAEVGERWKARFGLDILDGIGSTEMLHIFLSNrPGRVRY--GTTGKPVPGYEVELRDEDGGDVADGEPGELYVRGPS 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 414 VMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSS 493
Cdd:cd05959  368 SATMYWNNRDKTRDTFQGEWTRTGDKYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDG 447
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 494 GEAVKIFVVKK----DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05959  448 LTKPKAFVVLRpgyeDSEALEEELKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
FAA1 COG1022
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
19-487 1.31e-93

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];


Pssm-ID: 440645 [Multi-domain]  Cd Length: 603  Bit Score: 298.17  E-value: 1.31e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  19 PDRYQSLIELFEHSVRRYADQPAFVNMG----EVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGI 94
Cdd:COG1022    7 VPPADTLPDLLRRRAARFPDRVALREKEdgiwQSLTWAEFAERVRALAAGLLA-LGVKPGDRVAILSDNRPEWVIADLAI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  95 LRAGMIVVnvnPLY---TPRELEHQLNDSGAAaIVIVSNFAHtLEKVVE----KTQVKHVILTRMGDQLSTAKgtlvnfv 167
Cdd:COG1022   86 LAAGAVTV---PIYptsSAEEVAYILNDSGAK-VLFVEDQEQ-LDKLLEvrdeLPSLRHIVVLDPRGLRDDPR------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 168 VKYVKRLVP---KYHLPDAISFRRAlhagyrmqyvkpEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGp 244
Cdd:COG1022  154 LLSLDELLAlgrEVADPAELEARRA------------AVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLP- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 245 lLHPGkELVITALPLYHIFALTMnCLLFIELGGQNVLITNPRDIPGLVKELAkyPfTAMTGVNTLFNALLNN-------- 316
Cdd:COG1022  221 -LGPG-DRTLSFLPLAHVFERTV-SYYALAAGATVAFAESPDTLAEDLREVK--P-TFMLAVPRVWEKVYAGiqakaeea 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 317 KEFQQLDFST---------LHLSAGGGMP----VQQAVAERWV--KL---------------------TGQY-------L 353
Cdd:COG1022  295 GGLKRKLFRWalavgrryaRARLAGKSPSlllrLKHALADKLVfsKLrealggrlrfavsggaalgpeLARFfralgipV 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 354 LEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLvddednevphGEPGELCVRGPQVMLGYWQRPDATDE-IIKDG 432
Cdd:COG1022  375 LEGYGLTETSPVITVNRPG-DNRIGTVGPPLPGVEVKI----------AEDGEILVRGPNVMKGYYKNPEATAEaFDADG 443
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 433 WLHTGDIAVMDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:COG1022  444 WLHTGDIGELDEDGFLRITGRKKDLIvTSGGKNVAPQPIENALKASPLIEQAVVVG 499
FACL_fum10p_like cd05926
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...
37-551 2.26e-93

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.


Pssm-ID: 341249 [Multi-domain]  Cd Length: 493  Bit Score: 294.22  E-value: 2.26e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  37 ADQPAFV--NMGEVMTFRKLEERSRAFAAYLqEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:cd05926    1 PDAPALVvpGSTPALTYADLAELVDDLARQL-AALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 115 HQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTrmgdqlstakgtlvnfVVKYVKRLVPKYhlpDAISFRRALHAGY 194
Cdd:cd05926   80 FYLADLGSKLVLTPKGELGPASRAASKLGLAILELA----------------LDVGVLIRAPSA---ESLSNLLADKKNA 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 195 RMQyvkPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITaLPLYHIFALtMNCLLFIE 274
Cdd:cd05926  141 KSE---GVPLPDDLALILHTSGTTGRPKGVPLTHRNLAASATNITNTYK--LTPDDRTLVV-MPLFHVHGL-VASLLSTL 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 275 LGGQNVLITnPRDIPGLV-KELAKYPFTAMTGVNTLFNALLNN------KEFQQLDFSTlhlSAGGGMPVqqAVAERWVK 347
Cdd:cd05926  214 AAGGSVVLP-PRFSASTFwPDVRDYNATWYTAVPTIHQILLNRpepnpeSPPPKLRFIR---SCSASLPP--AVLEALEA 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 348 LTGQYLLEGYGLTECAPLVSVNPHDIDYHS-GSIGLPVpSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATD 426
Cdd:cd05926  288 TFGAPVLEAYGMTEAAHQMTSNPLPPGPRKpGSVGKPV-GVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANA 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 427 EI-IKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KK 504
Cdd:cd05926  367 EAaFKDGWFRTGDLGYLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAAAVVlRE 446
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 489956626 505 DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05926  447 GASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493
PRK07529 PRK07529
AMP-binding domain protein; Validated
10-561 4.95e-92

AMP-binding domain protein; Validated


Pssm-ID: 236043 [Multi-domain]  Cd Length: 632  Bit Score: 294.94  E-value: 4.95e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  10 PADVPA-EINP----DRYQSLIELFEHSVRRYADQPA--FV------NMGEVMTFRKLEER-SRAfaAYLQEGLGLQKGD 75
Cdd:PRK07529   7 LADIEAiEAVPlaarDLPASTYELLSRAAARHPDAPAlsFLldadplDRPETWTYAELLADvTRT--ANLLHSLGVGPGD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  76 RVALMMPNLLQYPVALFGILRAGmIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVEK-TQVKHVIL 149
Cdd:PRK07529  85 VVAFLLPNLPETHFALWGGEAAG-IANPINPLLEPEQIAELLRAAGAKVLVTLGPFpgtdiWQKVAEVLAAlPELRTVVE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 150 TRMGDQLSTAKGTLVNFvvkyvkrLVPKYHLPDaISFRRALHAGYRMQYVKPE-IVSEDLAFLQYTGGTTGVAKGAMLTH 228
Cdd:PRK07529 164 VDLARYLPGPKRLAVPL-------IRRKAHARI-LDFDAELARQPGDRLFSGRpIGPDDVAAYFHTGGTTGMPKLAQHTH 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 229 RNMLANLEQVNATYGplLHPGKeLVITALPLYHIFALTMNCLLFIeLGGQNVLITNP---RDiPGLVKEL----AKYPFT 301
Cdd:PRK07529 236 GNEVANAWLGALLLG--LGPGD-TVFCGLPLFHVNALLVTGLAPL-ARGAHVVLATPqgyRG-PGVIANFwkivERYRIN 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 302 AMTGVNTLFNALLnnkefQQ----LDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS 377
Cdd:PRK07529 311 FLSGVPTVYAALL-----QVpvdgHDISSLRYALCGAAPLPVEVFRRFEAATGVRIVEGYGLTEATCVSSVNPPDGERRI 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 378 GSIGLPVPSTEAKLV--DDEDN---EVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVD 452
Cdd:PRK07529 386 GSVGLRLPYQRVRVVilDDAGRylrDCAVDEVGVLCIAGPNVFSGYLEAAHNKGLWLEDGWLNTGDLGRIDADGYFWLTG 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 453 RKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV-VKKDPSLTEDALITFCRRQLTG-YKVPKLV 530
Cdd:PRK07529 466 RAKDLIIRGGHNIDPAAIEEALLRHPAVALAAAVGRPDAHAGELPVAYVqLKPGASATEAELLAFARDHIAErAAVPKHV 545
                        570       580       590
                 ....*....|....*....|....*....|.
gi 489956626 531 EFRDELPKSNVGKILRRELRDEARAKVDNKA 561
Cdd:PRK07529 546 RILDALPKTAVGKIFKPALRRDAIRRVLRAA 576
FACL_like_2 cd05917
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
211-550 2.64e-90

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341241 [Multi-domain]  Cd Length: 349  Bit Score: 281.47  E-value: 2.64e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 211 LQYTGGTTGVAKGAMLTHRNMLANLEQVnatyGPLLHPGKELVIT-ALPLYHIFALTMNCLLFIELGGQNVLITNPRDIP 289
Cdd:cd05917    7 IQFTSGTTGSPKGATLTHHNIVNNGYFI----GERLGLTEQDRLCiPVPLFHCFGSVLGVLACLTHGATMVFPSPSFDPL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 290 GLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTG-QYLLEGYGLTECAPLVSV 368
Cdd:cd05917   83 AVLEAIEKEKCTALHGVPTMFIAELEHPDFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNmKDVTIAYGMTETSPVSTQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 369 N-PHD-IDYHSGSIGLPVPSTEAKLVDDEDNEVPH-GEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDD 444
Cdd:cd05917  163 TrTDDsIEKRVNTVGRIMPHTEAKIVDPEGGIVPPvGVPGELCIRGYSVMKGYWNDPEKTAEAIdGDGWLHTGDLAVMDE 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV-VKKDPSLTEDALITFCRRQLTG 523
Cdd:cd05917  243 DGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIrLKEGAELTEEDIKAYCKGKIAH 322
                        330       340
                 ....*....|....*....|....*..
gi 489956626 524 YKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05917  323 YKVPRYVFFVDEFPLTVSGKIQKFKLR 349
MCS cd05941
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...
38-551 1.29e-88

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.


Pssm-ID: 341264 [Multi-domain]  Cd Length: 442  Bit Score: 280.33  E-value: 1.29e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd05941    1 DRIAIVDDGDSITYADLVARAARLANRLLALGKDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVivsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd05941   81 TDSEPSLVL----------------------------------------------------------------------- 89
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yvkpeivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ-VNA-TYGP---LLHpgkelvitALPLYHIFAL--TMNCL 270
Cdd:cd05941   90 ---------DPALILYTSGTTGRPKGVVLTHANLAANVRAlVDAwRWTEddvLLH--------VLPLHHVHGLvnALLCP 152
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 271 LFIelGGQNVLITNPRDIPGLVKELAKyPFTAMTGVNTLFNALL--NNKEFQQLDFST--------LHLSAGGGMPVQqa 340
Cdd:cd05941  153 LFA--GASVEFLPKFDPKEVAISRLMP-SITVFMGVPTIYTRLLqyYEAHFTDPQFARaaaaerlrLMVSGSAALPVP-- 227
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 341 VAERWVKLTGQYLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTEAKLVDDEDNE-VPHGEPGELCVRGPQVMLGYW 419
Cdd:cd05941  228 TLEEWEAITGHTLLERYGMTEIGMALS-NPLDGERRPGTVGMPLPGVQARIVDEETGEpLPRGEVGEIQVRGPSVFKEYW 306
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDAT-DEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAV 497
Cdd:cd05941  307 NKPEATkEEFTDDGWFKTGDLGVVDEDGYYWILGRSSVDIIKSgGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERV 386
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 498 KIFVVKKD--PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05941  387 VAVVVLRAgaAALSLEELKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKELRK 442
MACS_like cd05972
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...
50-551 2.68e-88

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.


Pssm-ID: 341276 [Multi-domain]  Cd Length: 428  Bit Score: 279.22  E-value: 2.68e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd05972    2 SFRELKRESAKAANVLA-KLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 nfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivsEDLA 209
Cdd:cd05972   81 ----------------------------------------------------------------------------EDPA 84
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 210 FLQYTGGTTGVAKGAMLTHRNMLANLeqVNATYGPLLHPGKELVITALP--LYHIFALTMNCLLfieLGGQNVLITNPR- 286
Cdd:cd05972   85 LIYFTSGTTGLPKGVLHTHSYPLGHI--PTAAYWLGLRPDDIHWNIADPgwAKGAWSSFFGPWL---LGATVFVYEGPRf 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 DIPGLVKELAKYPFTAMTGVNTLFNaLLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLV 366
Cdd:cd05972  160 DAERILELLERYGVTSFCGPPTAYR-MLIKQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLPIRDGYGQTETGLTV 238
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 367 SvNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVR--GPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDD 444
Cdd:cd05972  239 G-NFPDMPVKPGSMGRPTPGYDVAIIDDDGRELPPGEEGDIAIKlpPPGLFLGYVGDPEKTEASIRGDYYLTGDRAYRDE 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD-----PSLTEDaLITFCRR 519
Cdd:cd05972  318 DGYFWFVGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSgyepsEELAEE-LQGHVKK 396
                        490       500       510
                 ....*....|....*....|....*....|..
gi 489956626 520 QLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05972  397 VLAPYKYPREIEFVEELPKTISGKIRRVELRD 428
PLN02246 PLN02246
4-coumarate--CoA ligase
28-550 6.14e-84

4-coumarate--CoA ligase


Pssm-ID: 215137 [Multi-domain]  Cd Length: 537  Bit Score: 271.08  E-value: 6.14e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  28 LFEHsVRRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:PLN02246  29 CFER-LSEFSDRPCLIDgaTGRVYTYADVELLSRRVAAGLH-KLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTAN 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 106 PLYTPRELEHQLNDSGAAAIVIVSNFAhtlEKVVEKTQVKHVILTRMGDQlstakgtlvnfvvkyvkrlvpkyhlPDAIS 185
Cdd:PLN02246 107 PFYTPAEIAKQAKASGAKLIITQSCYV---DKLKGLAEDDGVTVVTIDDP-------------------------PEGCL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 186 FRRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVI-TALPLYHIFA 264
Cdd:PLN02246 159 HFSELTQADENELPEVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVIlCVLPMFHIYS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LtmNCLLFIEL-GGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMP----VQQ 339
Cdd:PLN02246 239 L--NSVLLCGLrVGAAILIMPKFEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVEKYDLSSIRMVLSGAAPlgkeLED 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 340 AVAerwVKLTGQYLLEGYGLTECAPLVSVNP----HDIDYHSGSIGLPVPSTEAKLVDDEDNE-VPHGEPGELCVRGPQV 414
Cdd:PLN02246 317 AFR---AKLPNAVLGQGYGMTEAGPVLAMCLafakEPFPVKSGSCGTVVRNAELKIVDPETGAsLPRNQPGEICIRGPQI 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 415 MLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSS 493
Cdd:PLN02246 394 MKGYLNDPEATANTIdKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVVPMKDEVA 473
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 494 GEAVKIFVVKKDPS-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PLN02246 474 GEVPVAFVVRSNGSeITEDEIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDLR 531
PRK07514 PRK07514
malonyl-CoA synthase; Validated
46-552 1.67e-83

malonyl-CoA synthase; Validated


Pssm-ID: 181011 [Multi-domain]  Cd Length: 504  Bit Score: 269.05  E-value: 1.67e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMM----PNLLQYpvalFGILRAGMIVVNVNPLYTPRELEHQLNDSG 121
Cdd:PRK07514  26 GLRYTYGDLDAASARLANLLV-ALGVKPGDRVAVQVekspEALALY----LATLRAGAVFLPLNTAYTLAELDYFIGDAE 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 122 AAAIVIVSNFAHTLEKVVEKTQVKHViLTRMGDqlstAKGTLVnfvvkyvkrlvpkyhlpdaisfRRALHAGYRMQYVKP 201
Cdd:PRK07514 101 PALVVCDPANFAWLSKIAAAAGAPHV-ETLDAD----GTGSLL----------------------EAAAAAPDDFETVPR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 202 EivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYG-----PLLHpgkelvitALPLYHIFAL--TMNCLLFIe 274
Cdd:PRK07514 154 G--ADDLAAILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWRftpddVLIH--------ALPIFHTHGLfvATNVALLA- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 275 lGGQnvLITNPRDIPGLVkeLAKYP-FTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYL 353
Cdd:PRK07514 223 -GAS--MIFLPKFDPDAV--LALMPrATVMMGVPTFYTRLLQEPRLTREAAAHMRLFISGSAPLLAETHREFQERTGHAI 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 354 LEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTEAKLVDDEDN-EVPHGEPGELCVRGPQVMLGYWQRPDAT-DEIIKD 431
Cdd:PRK07514 298 LERYGMTETNMNTS-NPYDGERRAGTVGFPLPGVSLRVTDPETGaELPPGEIGMIEVKGPNVFKGYWRMPEKTaEEFRAD 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 432 GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTE 510
Cdd:PRK07514 377 GFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEGVTAVVVpKPGAALDE 456
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 489956626 511 DALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07514 457 AAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLREQ 498
BCL_like cd05919
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...
39-550 7.66e-82

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.


Pssm-ID: 341243 [Multi-domain]  Cd Length: 436  Bit Score: 262.78  E-value: 7.66e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  39 QPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLN 118
Cdd:cd05919    1 KTAFYAADRSVTYGQLHDGANRLGSALR-NLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIAR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 119 DSgAAAIVIVSnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqy 198
Cdd:cd05919   80 DC-EARLVVTS--------------------------------------------------------------------- 89
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 199 vkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNML--ANLEQVNATYgplLHPGkELVITALPLYHIFALTMNCLLFIELG 276
Cdd:cd05919   90 ------ADDIAYLLYSSGTTGPPKGVMHAHRDPLlfADAMAREALG---LTPG-DRVFSSAKMFFGYGLGNSLWFPLAVG 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 277 GQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEG 356
Cdd:cd05919  160 ASAVLNPGWPTAERVLATLARFRPTVLYGVPTFYANLLDSCAGSPDALRSLRLCVSAGEALPRGLGERWMEHFGGPILDG 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 357 YGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHT 436
Cdd:cd05919  240 IGATEVGHIFLSNRPG-AWRLGSTGRPVPGYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFNGGWYRT 318
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 437 GDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALI-- 514
Cdd:cd05919  319 GDKFCRDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPAAPQESLArd 398
                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 489956626 515 --TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05919  399 ihRHLLERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
ttLC_FACS_AlkK_like cd12119
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
50-551 2.17e-81

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.


Pssm-ID: 341284 [Multi-domain]  Cd Length: 518  Bit Score: 263.72  E-value: 2.17e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd12119   27 TYAEVAERARRLANALRR-LGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFVDR 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 NFAHTLEKVVEK-TQVKHVILTRMGDqlstakgtlvnfvvkyvKRLVPkyHLPDAISFRRALHAGyRMQYVKPEIVSEDL 208
Cdd:cd12119  106 DFLPLLEAIAPRlPTVEHVVVMTDDA-----------------AMPEP--AGVGVLAYEELLAAE-SPEYDWPDFDENTA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 209 AFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGkELVITALPLYHI------FALTMncllfieLGGQNVLi 282
Cdd:cd12119  166 AAICYTSGTTGNPKGVVYSHRSLVLHAMAALLTDGLGLSES-DVVLPVVPMFHVnawglpYAAAM-------VGAKLVL- 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 TNPRDIPG-LVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLtGQYLLEGYGLTE 361
Cdd:cd12119  237 PGPYLDPAsLAELIEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLRRVVIGGSAVPRSLIEAFEER-GVRVIHAWGMTE 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 362 CAPLVSVNpHDIDYHSG-----------SIGLPVPSTEAKLVDDEDNEVPH--GEPGELCVRGPQVMLGYWQRPDATDEI 428
Cdd:cd12119  316 TSPLGTVA-RPPSEHSNlsedeqlalraKQGRPVPGVELRIVDDDGRELPWdgKAVGELQVRGPWVTKSYYKNDEESEAL 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 429 IKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGE-AVKIFVVKKDPS 507
Cdd:cd12119  395 TEDGWLRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGErPLAVVVLKEGAT 474
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 489956626 508 LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd12119  475 VTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALRE 518
PRK07470 PRK07470
acyl-CoA synthetase; Validated
21-552 9.00e-79

acyl-CoA synthetase; Validated


Pssm-ID: 180988 [Multi-domain]  Cd Length: 528  Bit Score: 257.28  E-value: 9.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  21 RYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMI 100
Cdd:PRK07470   5 RVMNLAHFLRQAARRFPDRIALVWGDRSWTWREIDARVDALAAALAA-RGVRKGDRILVHSRNCNQMFESMFAAFRLGAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 101 VVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKT-QVKHVIltrmgdQLSTAKGTlvnfvvkyvkrlvPKYh 179
Cdd:PRK07470  84 WVPTNFRQTPDEVAYLAEASGARAMICHADFPEHAAAVRAASpDLTHVV------AIGGARAG-------------LDY- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 180 lpDAISfrrALHAGYRmqyVKPEIVS-EDLAFLQYTGGTTGVAKGAMLTHRNM-------LANLeqVNATygplLHPGKE 251
Cdd:PRK07470 144 --EALV---ARHLGAR---VANAAVDhDDPCWFFFTSGTTGRPKAAVLTHGQMafvitnhLADL--MPGT----TEQDAS 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 252 LVITalPLYH---IFALTMncllfIELGGQNVLITNPR-DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL 327
Cdd:PRK07470 210 LVVA--PLSHgagIHQLCQ-----VARGAATVLLPSERfDPAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSL 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 328 HLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDID----YHSGSIGLPVPSTEAKLVDDEDNEVP 400
Cdd:PRK07470 283 RYVIYAGAPMYRADQKRALAKLGKVLVQYFGLGEVTGNITVLPpalHDAEdgpdARIGTCGFERTGMEVQIQDDEGRELP 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 401 HGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:PRK07470 363 PGETGEICVIGPAVFAGYYNNPEANAKAFRDGWFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAV 442
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489956626 481 LEVAAVGVPSGSSGE-AVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07470 443 SEVAVLGVPDPVWGEvGVAVCVARDGAPVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVREE 515
CHC_CoA_lg cd05903
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...
48-550 1.09e-78

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.


Pssm-ID: 341229 [Multi-domain]  Cd Length: 437  Bit Score: 254.23  E-value: 1.09e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  48 VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVI 127
Cdd:cd05903    1 RLTYSELDTRADRLAAGLAA-LGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 128 VSNFAhtlekvvektQVKHViltrmgdqlstakgtlvnfvvkyvkrlvpkyHLPDAIsfrralhagyrmqyvkpeivsed 207
Cdd:cd05903   80 PERFR----------QFDPA-------------------------------AMPDAV----------------------- 95
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 208 lAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpllHPGKELVITALPLYHIFALTMNCLLFIELGGQNVL--ITNP 285
Cdd:cd05903   96 -ALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLG---LGPGDVFLVASPMAHQTGFVYGFTLPLLLGAPVVLqdIWDP 171
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 286 RDIPGLVKElakYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECA-P 364
Cdd:cd05903  172 DKALALMRE---HGVTFMMGATPFLTDLLNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAKVCSAYGSTECPgA 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 365 LVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDD 444
Cdd:cd05903  249 VTSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAPGVEGELLSRGPSVFLGYLDRPDLTADAAPEGWFRTGDLARLDE 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDP-SLTEDALITFCRRQ-LT 522
Cdd:cd05903  329 DGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSGaLLTFDELVAYLDRQgVA 408
                        490       500
                 ....*....|....*....|....*...
gi 489956626 523 GYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05903  409 KQYWPERLVHVDDLPRTPSGKVQKFRLR 436
PRK06087 PRK06087
medium-chain fatty-acid--CoA ligase;
24-552 9.22e-77

medium-chain fatty-acid--CoA ligase;


Pssm-ID: 180393 [Multi-domain]  Cd Length: 547  Bit Score: 252.75  E-value: 9.22e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  24 SLIELFEHSVRRYADQPAFV-NMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK06087  24 SLADYWQQTARAMPDKIAVVdNHGASYTYSALDHAASRLANWLLA-KGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 103 NVNPLYTPRELEHQLNDSGAAAIvivsnFAHTLEKvveKTQVKHVILTrMGDQLSTAKGTLVnfvvkyVKRLVPKYhlpD 182
Cdd:PRK06087 103 PLLPSWREAELVWVLNKCQAKMF-----FAPTLFK---QTRPVDLILP-LQNQLPQLQQIVG------VDKLAPAT---S 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 183 AISFRRALHAGYRMQYvKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATygpLLHPGKELVITALPLYHI 262
Cdd:PRK06087 165 SLSLSQIIADYEPLTT-AITTHGDELAAVLFTSGTEGLPKGVMLTHNNILASERAYCAR---LNLTWQDVFMMPAPLGHA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 263 FALTMNCLLFIELGGQNVL--ITNPRDIPGLvkeLAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQA 340
Cdd:PRK06087 241 TGFLHGVTAPFLIGARSVLldIFTPDACLAL---LEQQRCTCMLGATPFIYDLLNLLEKQPADLSALRFFLCGGTTIPKK 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 341 VAERwVKLTGQYLLEGYGLTECAPLVSVNPHD-IDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYW 419
Cdd:PRK06087 318 VARE-CQQRGIKLLSVYGSTESSPHAVVNLDDpLSRFMHTDGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYL 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVK 498
Cdd:PRK06087 397 DEPELTARALdEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGERSC 476
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 499 IFVVKKDPSLT---EDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06087 477 AYVVLKAPHHSltlEEVVAFFSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKD 533
EntE COG1021
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...
8-555 1.83e-76

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440644 [Multi-domain]  Cd Length: 533  Bit Score: 251.22  E-value: 1.83e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   8 RYPADVPAeinpdRY--------QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVAL 79
Cdd:COG1021    7 PWPEEFAA-----RYreagywrgETLGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLA-LGLRPGDRVVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  80 MMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS--------NFAHTLEKVVEktQVKHVILTr 151
Cdd:COG1021   81 QLPNVAEFVIVFFALFRAGAIPVFALPAHRRAEISHFAEQSEAVAYIIPDrhrgfdyrALARELQAEVP--SLRHVLVV- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 152 mGDQlstakgtlvnfvvkyvkrlvpkyhlPDAISFRRALHAGyrMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:COG1021  158 -GDA-------------------------GEFTSLDALLAAP--ADLSEPRPDPDDVAFFQLSGGTTGLPKLIPRTHDDY 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 232 LANLEQVNA--------TYgpllhpgkeLVitALPLYHIFALTMNCLL-FIELGGQNVLITNPRdiPGLVKEL-AKYPFT 301
Cdd:COG1021  210 LYSVRASAEicgldadtVY---------LA--ALPAAHNFPLSSPGVLgVLYAGGTVVLAPDPS--PDTAFPLiERERVT 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 302 AMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTEcaPLVSVN----PHDIDYHS 377
Cdd:COG1021  277 VTALVPPLALLWLDAAERSRYDLSSLRVLQVGGAKLSPELARRVRPALGCTLQQVFGMAE--GLVNYTrlddPEEVILTT 354
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 378 gsIGLPV-PSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDAT----DEiikDGWLHTGDIAVMDDEGFLRIVD 452
Cdd:COG1021  355 --QGRPIsPDDEVRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRAPEHNarafTP---DGFYRTGDLVRRTPDGYLVVEG 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 453 RKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFCR-RQLTGYKVPKLVE 531
Cdd:COG1021  430 RAKDQINRGGEKIAAEEVENLLLAHPAVHDAAVVAMPDEYLGERSCAFVVPRGEPLTLAELRRFLReRGLAAFKLPDRLE 509
                        570       580
                 ....*....|....*....|....
gi 489956626 532 FRDELPKSNVGKILRRELRDEARA 555
Cdd:COG1021  510 FVDALPLTAVGKIDKKALRAALAA 533
VL_LC_FACS_like cd05907
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...
49-487 3.01e-76

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341233 [Multi-domain]  Cd Length: 452  Bit Score: 248.28  E-value: 3.01e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLY---TPRELEHQLNDSGAAAI 125
Cdd:cd05907    6 ITWAEFAEEVRALAKGLI-ALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPV---PIYptsSAEQIAYILNDSEAKAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 vIVSNfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivS 205
Cdd:cd05907   82 -FVED--------------------------------------------------------------------------P 86
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqvnATYGPLLHPGK-ELVITALPLYHIFALTMNCLLFIELGGQNVLitn 284
Cdd:cd05907   87 DDLATIIYTSGTTGRPKGVMLSHRNILSNA----LALAERLPATEgDRHLSFLPLAHVFERRAGLYVPLLAGARIYF--- 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 285 PRDIPGLVKELAKYPFTAMTGVNTLFNALLNN------KEFQQLDFSTLHLS-----AGGGMPVQQAVAERWVKLtGQYL 353
Cdd:cd05907  160 ASSAETLLDDLSEVRPTVFLAVPRVWEKVYAAikvkavPGLKRKLFDLAVGGrlrfaASGGAPLPAELLHFFRAL-GIPV 238
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 354 LEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLVDDednevphgepGELCVRGPQVMLGYWQRPDATDE-IIKDG 432
Cdd:cd05907  239 YEGYGLTETSAVVTLNPPG-DNRIGTVGKPLPGVEVRIADD----------GEILVRGPNVMLGYYKNPEATAEaLDADG 307
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 433 WLHTGDIAVMDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:cd05907  308 WLHTGDLGEIDEDGFLHITGRKKDLIITSgGKNISPEPIENALKASPLISQAVVIG 363
Firefly_Luc cd17642
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...
14-551 1.98e-75

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341297 [Multi-domain]  Cd Length: 532  Bit Score: 248.60  E-value: 1.98e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  14 PAEINPDRYQSLIELFEHSVRRYADQP---AFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYP 88
Cdd:cd17642    5 PGPFYPLEDGTAGEQLHKAMKRYASVPgtiAFTDahTGVNYSYAEYLEMSVRLAEALKK-YGLKQNDRIAVCSENSLQFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  89 VALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAIVIVSNfaHTLEKVVE-KTQVKHVILTRMGDQLSTAKG--TLVN 165
Cdd:cd17642   84 LPVIAGLFIGVGVAPTNDIYNERELDHSLNIS-KPTIVFCSK--KGLQKVLNvQKKLKIIKTIIILDSKEDYKGyqCLYT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 166 FVvkyvkrlvpKYHLPdaisfrralhAGYRMQYVKPEIVS--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLE-QVNATY 242
Cdd:cd17642  161 FI---------TQNLP----------PGFNEYDFKPPSFDrdEQVALIMNSSGSTGLPKGVQLTHKNIVARFShARDPIF 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 243 GPLLHPGKElVITALPLYHIFALTmNCLLFIELGGQNVLITNpRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQL 322
Cdd:cd17642  222 GNQIIPDTA-ILTVIPFHHGFGMF-TTLGYLICGFRVVLMYK-FEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVDKY 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 323 DFSTLHLSAGGGMP----VQQAVAERwVKLTGqyLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTEAKLVD-DEDN 397
Cdd:cd17642  299 DLSNLHEIASGGAPlskeVGEAVAKR-FKLPG--IRQGYGLTETTSAILITP-EGDDKPGAVGKVVPFFYAKVVDlDTGK 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 398 EVPHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:cd17642  375 TLGPNERGELCVKGPMIMKGYVNNPEATKALIdKDGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQ 454
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 477 HSGVLEVAAVGVPSGSSGEAVKIFVVKK-DPSLTEDALITFCRRQLTGYKvpKL---VEFRDELPKSNVGKILRRELRD 551
Cdd:cd17642  455 HPKIFDAGVAGIPDEDAGELPAAVVVLEaGKTMTEKEVMDYVASQVSTAK--RLrggVKFVDEVPKGLTGKIDRRKIRE 531
PRK03640 PRK03640
o-succinylbenzoate--CoA ligase;
38-552 1.54e-74

o-succinylbenzoate--CoA ligase;


Pssm-ID: 235146 [Multi-domain]  Cd Length: 483  Bit Score: 244.87  E-value: 1.54e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQ-YPV--ALFGIlraGMIVVNVNPLYTPRELE 114
Cdd:PRK03640  17 DRTAIEFEEKKVTFMELHEAVVSVAGKLA-ALGVKKGDRVALLMKNGMEmILVihALQQL---GAVAVLLNTRLSREELL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 115 HQLNDSGAAAIVIVSNFAHtleKVVEKTQVKHVILtrmgdqlstAKGTLVNFVvkyvkrLVPKYHLpdaisfrralhagy 194
Cdd:PRK03640  93 WQLDDAEVKCLITDDDFEA---KLIPGISVKFAEL---------MNGPKEEAE------IQEEFDL-------------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 195 rmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLAnleqvnATYGPLLHPG---KELVITALPLYHI--FALTMNC 269
Cdd:PRK03640 141 -----------DEVATIMYTSGTTGKPKGVIQTYGNHWW------SAVGSALNLGlteDDCWLAAVPIFHIsgLSILMRS 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 270 LLFielgGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLnnKEFQQL----DFSTLHLsaGGGmPVQQAVAERw 345
Cdd:PRK03640 204 VIY----GMRVVLVEKFDAEKINKLLQTGGVTIISVVSTMLQRLL--ERLGEGtypsSFRCMLL--GGG-PAPKPLLEQ- 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEdNEVPHGEPGELCVRGPQVMLGYWQRPDA 424
Cdd:PRK03640 274 CKEKGIPVYQSYGMTEtASQIVTLSPEDALTKLGSAGKPLFPCELKIEKDG-VVVPPFEEGEIVVKGPNVTKGYLNREDA 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 425 TDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGeAVKIFVVKK 504
Cdd:PRK03640 353 TRETFQDGWFKTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWG-QVPVAFVVK 431
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 489956626 505 DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK03640 432 SGEVTEEELRHFCEEKLAKYKVPKRFYFVEELPRNASGKLLRHELKQL 479
PLN02330 PLN02330
4-coumarate--CoA ligase-like 1
4-552 8.82e-74

4-coumarate--CoA ligase-like 1


Pssm-ID: 215189 [Multi-domain]  Cd Length: 546  Bit Score: 244.89  E-value: 8.82e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   4 VWLNRYPAdVPAeinPDRYqSLIELFEHSVRRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMM 81
Cdd:PLN02330  14 IFRSRYPS-VPV---PDKL-TLPDFVLQDAELYADKVAFVEavTGKAVTYGEVVRDTRRFAKALRS-LGLRKGQVVVVVL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  82 PNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaiVIVSNFAHtLEKVvektqvkhviltrmgdqlstaKG 161
Cdd:PLN02330  88 PNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAK--LIVTNDTN-YGKV---------------------KG 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 162 TLVNFVVkyvkrlVPKYHLPDAISFRRALHAGYRM--QYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVN 239
Cdd:PLN02330 144 LGLPVIV------LGEEKIEGAVNWKELLEAADRAgdTSDNEEILQTDLCALPFSSGTTGISKGVMLTHRNLVANLCSSL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 240 ATYGPLLhPGKELVITALPLYHIFALTMNCLLFIELGGQnVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEF 319
Cdd:PLN02330 218 FSVGPEM-IGQVVTLGLIPFFHIYGITGICCATLRNKGK-VVVMSRFELRTFLNALITQEVSFAPIVPPIILNLVKNPIV 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 320 QQLDFSTLHLSA--GGGMPVQQAVAERW-VKLTGQYLLEGYGLTE--CAPLVSVNP---HDIDyHSGSIGLPVPSTEAKL 391
Cdd:PLN02330 296 EEFDLSKLKLQAimTAAAPLAPELLTAFeAKFPGVQVQEAYGLTEhsCITLTHGDPekgHGIA-KKNSVGFILPNLEVKF 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 392 VD-DEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PLN02330 375 IDpDTGRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIdEDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAE 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 470 IEDVVMQHSGVLEVAAVGVPSGSSGE-AVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:PLN02330 455 LEAILLTHPSVEDAAVVPLPDEEAGEiPAACVVINPKAKESEEDILNFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRL 534

                 ....
gi 489956626 549 LRDE 552
Cdd:PLN02330 535 LKEK 538
ABCL cd05958
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...
39-550 1.53e-73

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.


Pssm-ID: 341268 [Multi-domain]  Cd Length: 439  Bit Score: 240.84  E-value: 1.53e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  39 QPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLN 118
Cdd:cd05958    1 RTCLRSPEREWTYRDLLALANRIANVLVGELGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYILD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 119 DSGAAAIVIVsnfahtlekvvektqvkhviltrmgDQLSTakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqy 198
Cdd:cd05958   81 KARITVALCA-------------------------HALTA---------------------------------------- 95
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 199 vkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvnaTYGP-LLHPGKELVITALP-LYHIFALTMNCLLFIELG 276
Cdd:cd05958   96 ------SDDICILAFTSGTTGAPKATMHFHRDPLASAD----RYAVnVLRLREDDRFVGSPpLAFTFGLGGVLLFPFGVG 165
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 277 GQNVLI--TNPRDIPGLVkelAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL--SAGGGMPvqQAVAERWVKLTGQY 352
Cdd:cd05958  166 ASGVLLeeATPDLLLSAI---ARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKcvSAGEALP--AALHRAWKEATGIP 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 LLEGYGLTECAPL-VSVNPHDIdyHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQvmlGYWQRPDATDE-IIK 430
Cdd:cd05958  241 IIDGIGSTEMFHIfISARPGDA--RPGATGKPVPGYEAKVVDDEGNPVPDGTIGRLAVRGPT---GCRYLADKRQRtYVQ 315
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 431 DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKK-----D 505
Cdd:cd05958  316 GGWNITGDTYSRDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRpgvipG 395
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 489956626 506 PSLTEdALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05958  396 PVLAR-ELQDHAKAHIAPYKYPRAIEFVTELPRTATGKLQRFALR 439
MACS_like_3 cd05971
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
47-551 2.79e-73

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341275 [Multi-domain]  Cd Length: 439  Bit Score: 240.41  E-value: 2.79e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  47 EVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIV 126
Cdd:cd05971    5 EKVTFKELKTASNRFANVLKE-IGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 127 IvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpDAisfrralhagyrmqyvkpeivSE 206
Cdd:cd05971   84 T------------------------------------------------------DG---------------------SD 88
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpLLHPGKELVITALPLYHIFALtMNCLLFIELGGQNVLITNPR 286
Cdd:cd05971   89 DPALIIYTSGTTGPPKGALHAHRVLLGHLPGVQFPFN-LFPRDGDLYWTPADWAWIGGL-LDVLLPSLYFGVPVLAHRMT 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 --DIPGLVKELAKYpftamtGVNTLF---NAL-LNNKEFQQLDFSTLHLSA---GGGMPVQQAVAerWVKLT-GQYLLEG 356
Cdd:cd05971  167 kfDPKAALDLMSRY------GVTTAFlppTALkMMRQQGEQLKHAQVKLRAiatGGESLGEELLG--WAREQfGVEVNEF 238
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 357 YGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQ--VMLGYWQRPDATDEIIKDGWL 434
Cdd:cd05971  239 YGQTECNLVIGNCSALFPIKPGSMGKPIPGHRVAIVDDNGTPLPPGEVGEIAVELPDpvAFLGYWNNPSATEKKMAGDWL 318
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 435 HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALI 514
Cdd:cd05971  319 LTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPGETPSDALA 398
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 489956626 515 ----TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05971  399 reiqELVKTRLAAHEYPREIEFVNELPRTATGKIRRRELRA 439
ACLS-CaiC cd17637
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...
213-546 5.35e-73

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341292 [Multi-domain]  Cd Length: 333  Bit Score: 236.01  E-value: 5.35e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 213 YTGGTTGVAKGAMLTHRNMLANLEQVNATYGpLLHPGKELVItaLPLYHIFALTMNcLLFIELGGQNVLITNpRDIPGLV 292
Cdd:cd17637    7 HTAAVAGRPRGAVLSHGNLIAANLQLIHAMG-LTEADVYLNM--LPLFHIAGLNLA-LATFHAGGANVVMEK-FDPAEAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 293 KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqqAVAERWVKLTGQYLLEGYGLTECAPLVSVnpHD 372
Cdd:cd17637   82 ELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSLRHVLGLDAP---ETIQRFEETTGATFWSLYGQTETSGLVTL--SP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 373 IDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVD 452
Cdd:cd17637  157 YRERPGSAGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNGWHHTGDLGRFDEDGYLWYAG 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 453 RK--KDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVK-IFVVKKDPSLTEDALITFCRRQLTGYKVPKL 529
Cdd:cd17637  237 RKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKaVCVLKPGATLTADELIEFVGSRIARYKKPRY 316
                        330
                 ....*....|....*..
gi 489956626 530 VEFRDELPKSNVGKILR 546
Cdd:cd17637  317 VVFVEALPKTADGSIDR 333
PLN02574 PLN02574
4-coumarate--CoA ligase-like
46-560 8.76e-73

4-coumarate--CoA ligase-like


Pssm-ID: 215312 [Multi-domain]  Cd Length: 560  Bit Score: 242.44  E-value: 8.76e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAai 125
Cdd:PLN02574  64 GFSISYSELQPLVKSMAAGLYHVMGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIKKRVVDCSVG-- 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 vivsnFAHTLEKVVEKtqvkhviLTRMGdqlstakgtlvnfvvkyvkrlVPKYHLPDAISF---RRALHAGYRMQY---- 198
Cdd:PLN02574 142 -----LAFTSPENVEK-------LSPLG---------------------VPVIGVPENYDFdskRIEFPKFYELIKedfd 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 199 --VKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ-VNATYGPLLHPGKELV-ITALPLYHIFALTMNCLLFIE 274
Cdd:PLN02574 189 fvPKPVIKQDDVAAIMYSSGTTGASKGVVLTHRNLIAMVELfVRFEASQYEYPGSDNVyLAALPMFHIYGLSLFVVGLLS 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 275 LGgQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNN-KEFQQLDFSTLHLSAGGGMPVQQAVAERWVK-LTGQY 352
Cdd:PLN02574 269 LG-STIVVMRRFDASDMVKVIDRFKVTHFPVVPPILMALTKKaKGVCGEVLKSLKQVSCGAAPLSGKFIQDFVQtLPHVD 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 LLEGYGLTECAPLVS--VNPHDIDYHSgSIGLPVPSTEAKLVDDEDNE-VPHGEPGELCVRGPQVMLGYWQRPDATD-EI 428
Cdd:PLN02574 348 FIQGYGMTESTAVGTrgFNTEKLSKYS-SVGLLAPNMQAKVVDWSTGClLPPGNCGELWIQGPGVMKGYLNNPKATQsTI 426
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 429 IKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPS- 507
Cdd:PLN02574 427 DKDGWLRTGDIAYFDEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRRQGSt 506
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489956626 508 LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
Cdd:PLN02574 507 LSQEAVINYVAKQVAPYKKVRKVVFVQSIPKSPAGKILRRELKRSLTNSVSSR 559
FadD3 cd17638
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...
207-546 1.94e-72

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.


Pssm-ID: 341293 [Multi-domain]  Cd Length: 330  Bit Score: 234.70  E-value: 1.94e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnLEQVNATYGPLLHPGKELVITalPLYHIFALTMNCLLFIeLGGQNVLITNPR 286
Cdd:cd17638    1 DVSDIMFTSGTTGRSKGVMCAHRQTLR-AAAAWADCADLTEDDRYLIIN--PFFHTFGYKAGIVACL-LTGATVVPVAVF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERW-VKLTGQYLLEGYGLTECAPL 365
Cdd:cd17638   77 DVDAILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMrSELGFETVLTAYGLTEAGVA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 366 VSVNPHD-IDYHSGSIGLPVPSTEAKLVDDednevphgepGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMD 443
Cdd:cd17638  157 TMCRPGDdAETVATTCGRACPGFEVRIADD----------GEVLVRGYNVMQGYLDDPEATAEAIdADGWLHTGDVGELD 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDP-SLTEDALITFCRRQLT 522
Cdd:cd17638  227 ERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVARPGvTLTEEDVIAWCRERLA 306
                        330       340
                 ....*....|....*....|....
gi 489956626 523 GYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17638  307 NYKVPRFVRFLDELPRNASGKVMK 330
AAS_C cd05909
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...
46-553 2.46e-72

C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.


Pssm-ID: 341235 [Multi-domain]  Cd Length: 490  Bit Score: 239.16  E-value: 2.46e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQEGLglQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05909    5 GTSLTYRKLLTGAIALARKLAKMT--KEGENVGVMLPPSAGGALANFALALSGKVPVMLNYTAGLRELRACIKLAGIKTV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VivsnfahTLEKVVEKTQVKHVIltrmgDQLSTAKgtlvnfvVKYVKRLVPKYHLPDAIsfRRALHA------GYRMQYV 199
Cdd:cd05909   83 L-------TSKQFIEKLKLHHLF-----DVEYDAR-------IVYLEDLRAKISKADKC--KAFLAGkfppkwLLRIFGV 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 200 KPEiVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllhPGKELVITALPLYHIFALTMNCLLFIELGGQN 279
Cdd:cd05909  142 APV-QPDDPAVILFTSGSEGLPKGVVLSHKNLLANVEQITAIFDP---NPEDVVFGALPFFHSFGLTGCLWLPLLSGIKV 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 280 VLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKefQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGL 359
Cdd:cd05909  218 VFHPNPLDYKKIPELIYDKKATILLGTPTFLRGYARAA--HPEDFSSLRLVVAGAEKLKDTLRQEFQEKFGIRILEGYGT 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 360 TECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDN-EVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGD 438
Cdd:cd05909  296 TECSPVISVNTPQSPNKEGTVGRPLPGMEVKIVSVETHeEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAFGDGWYDTGD 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 439 IAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGV-LEVAAVGVPSGSSGEavKIFVVKKDPSLTEDALITFC 517
Cdd:cd05909  376 IGKIDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEILPEdNEVAVVSVPDGRKGE--KIVLLTTTTDTDPSSLNDIL 453
                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 489956626 518 RR-QLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05909  454 KNaGISNLAKPSYIHQVEEIPLLGTGKPDYVTLKALA 490
PRK07786 PRK07786
long-chain-fatty-acid--CoA ligase; Validated
38-555 1.34e-71

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 169098 [Multi-domain]  Cd Length: 542  Bit Score: 238.91  E-value: 1.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQE-GLGLqkGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQ 116
Cdd:PRK07786  32 DAPALRFLGNTTTWRELDDRVAALAGALSRrGVGF--GDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLTPPEIAFL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 117 LNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTrMGDqlSTAKGTLvnfvvkyvkrlvpkyHLPDAISFRRALHAgyrm 196
Cdd:PRK07786 110 VSDCGAHVVVTEAALAPVATAVRDIVPLLSTVVV-AGG--SSDDSVL---------------GYEDLLAEAGPAHA---- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 197 qyvkPEIVSEDL-AFLQYTGGTTGVAKGAMLTHRNMLAnlEQVNATYGPLLHPGKELVITALPLYHIFALTmNCLLFIEL 275
Cdd:PRK07786 168 ----PVDIPNDSpALIMYTSGTTGRPKGAVLTHANLTG--QAMTCLRTNGADINSDVGFVGVPLFHIAGIG-SMLPGLLL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 276 GGQNVLI-TNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLL 354
Cdd:PRK07786 241 GAPTVIYpLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLALRVLSWGAAPASDTLLRQMAATFPEAQIL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 355 EGYGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGW 433
Cdd:PRK07786 321 AAFGQTEMSPVTCMlLGEDAIRKLGSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGGW 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 434 LHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEaVKIFVVKKDPS---LTE 510
Cdd:PRK07786 401 FHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKWGE-VPVAVAAVRNDdaaLTL 479
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 489956626 511 DALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARA 555
Cdd:PRK07786 480 EDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRERYGA 524
FACL_like_6 cd05922
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
60-550 3.83e-71

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341246 [Multi-domain]  Cd Length: 457  Bit Score: 235.41  E-value: 3.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  60 AFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAG----MIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTL 135
Cdd:cd05922    4 SAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGgrlgLVFVPLNPTLKESVLRYLVADAGGRIVLADAGAADRL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 136 EKVvektqvkhviLTRMGDQLSTAKGtlvnfvvkyvkrlvpkyhlpDAISFRRALHAGYrmqyvkpEIVSEDLAFLQYTG 215
Cdd:cd05922   84 RDA----------LPASPDPGTVLDA--------------------DGIRAARASAPAH-------EVSHEDLALLLYTS 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 216 GTTGVAKGAMLTHRNMLANLEQVNATYGplLHpGKELVITALPLYHIFALtmNCLLFIELGGQNVLITNPRDIP-GLVKE 294
Cdd:cd05922  127 GSTGSPKLVRLSHQNLLANARSIAEYLG--IT-ADDRALTVLPLSYDYGL--SVLNTHLLRGATLVLTNDGVLDdAFWED 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 295 LAKYPFTAMTGVNTLFnALLNNKEFQQLDFSTLHL--SAGGGMPvQQAVAERWVKLTGQYLLEGYGLTECAPLVS-VNPH 371
Cdd:cd05922  202 LREHGATGLAGVPSTY-AMLTRLGFDPAKLPSLRYltQAGGRLP-QETIARLRELLPGAQVYVMYGQTEATRRMTyLPPE 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 372 DIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDA-TDEIIKDGWLHTGDIAVMDDEGFLRI 450
Cdd:cd05922  280 RILEKPGSIGLAIPGGEFEILDDDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYrRKEGRGGGVLHTGDLARRDEDGFLFI 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 451 VDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSgSSGEAVKIFVVKKDpSLTEDALITFCRRQLTGYKVPKLV 530
Cdd:cd05922  360 VGRRDRMIKLFGNRISPTEIEAAARSIGLIIEAAAVGLPD-PLGEKLALFVTAPD-KIDPKDVLRSLAERLPPYKVPATV 437
                        490       500
                 ....*....|....*....|
gi 489956626 531 EFRDELPKSNVGKILRRELR 550
Cdd:cd05922  438 RVVDELPLTASGKVDYAALR 457
PRK08276 PRK08276
long-chain-fatty-acid--CoA ligase; Validated
46-561 2.30e-70

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236215 [Multi-domain]  Cd Length: 502  Bit Score: 234.41  E-value: 2.30e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:PRK08276   9 GEVVTYGELEARSNRLAHGLRA-LGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDSGAKVL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIVSNFAHTLEKVVEKTQvKHVILTRMGDqlstakGTlVNFVVKYVKRL--VPKYHLPDAIsfrralhAGYRMQYvkpei 203
Cdd:PRK08276  88 IVSAALADTAAELAAELP-AGVPLLLVVA------GP-VPGFRSYEEALaaQPDTPIADET-------AGADMLY----- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 vsedlaflqyTGGTTGVAKGAM--LTHRNMLANLEQ--VNATYGPLLHPGKELVITAlPLYHIfALTMNCLLFIELGGQN 279
Cdd:PRK08276 148 ----------SSGTTGRPKGIKrpLPGLDPDEAPGMmlALLGFGMYGGPDSVYLSPA-PLYHT-APLRFGMSALALGGTV 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 280 VLitNPR-DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLHLSAGGGMP----VQQAVAERWvkltGQY 352
Cdd:PRK08276 216 VV--MEKfDAEEALALIERYRVTHSQLVPTMFVRMLKLPEEvrARYDVSSLRVAIHAAAPcpveVKRAMIDWW----GPI 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 LLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEI-IKD 431
Cdd:PRK08276 290 IHEYYASSEGGGVTVITSEDWLAHPGSVGKAVLG-EVRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAArNPH 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 432 GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTED 511
Cdd:PRK08276 369 GWVTVGDVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVQPADGADAGD 448
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489956626 512 A----LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNKA 561
Cdd:PRK08276 449 AlaaeLIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRDRYWEGRQRAI 502
OSB_CoA_lg cd05912
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...
50-551 5.19e-70

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.


Pssm-ID: 341238 [Multi-domain]  Cd Length: 411  Bit Score: 230.70  E-value: 5.19e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgaaaivivs 129
Cdd:cd05912    3 TFAELFEEVSRLAEHLAA-LGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDS--------- 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 nfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpEIVSEDLA 209
Cdd:cd05912   73 ------------------------------------------------------------------------DVKLDDIA 80
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPgKELVITALPLYHIFALT--MNCLLFielgGQNVLITNPRD 287
Cdd:cd05912   81 TIMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLG--LTE-DDNWLCALPLFHISGLSilMRSVIY----GMTVYLVDKFD 153
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 288 IPGLVKELAKYPFTAMTGVNTLFNALLnnKEFQQLDFSTLHLSAGGGMPVQQAVAERwVKLTGQYLLEGYGLTE-CAPLV 366
Cdd:cd05912  154 AEQVLHLINSGKVTIISVVPTMLQRLL--EILGEGYPNNLRCILLGGGPAPKPLLEQ-CKEKGIPVYQSYGMTEtCSQIV 230
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 367 SVNPHDIDYHSGSIGLPVPSTEAKLVDDEdneVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEG 446
Cdd:cd05912  231 TLSPEDALNKIGSAGKPLFPVELKIEDDG---QPPYEVGEILLKGPNVTKGYLNRPDATEESFENGWFKTGDIGYLDEEG 307
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 447 FLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPsLTEDALITFCRRQLTGYKV 526
Cdd:cd05912  308 FLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSERP-ISEEELIAYCSEKLAKYKV 386
                        490       500
                 ....*....|....*....|....*
gi 489956626 527 PKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05912  387 PKKIYFVDELPRTASGKLLRHELKQ 411
ttLC_FACS_AEE21_like cd12118
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...
36-551 3.94e-69

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.


Pssm-ID: 341283 [Multi-domain]  Cd Length: 486  Bit Score: 230.65  E-value: 3.94e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  36 YADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:cd12118   17 YPDRTSIVYGDRRYTWRQTYDRCRRLASALA-ALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLDAEEIAF 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 116 QLNDSGAAAIVIVSNFAHTlekvvektqvkhviltrmgDQLSTAKGTlvnfvvkyvkrlvPKYHLP----DAISfrralh 191
Cdd:cd12118   96 ILRHSEAKVLFVDREFEYE-------------------DLLAEGDPD-------------FEWIPPadewDPIA------ 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 192 agyrmqyvkpeivsedlafLQYTGGTTGVAKGAMLTHRN-MLANLEQVnATYGPLLHPGkelVITALPLYH------IFA 264
Cdd:cd12118  138 -------------------LNYTSGTTGRPKGVVYHHRGaYLNALANI-LEWEMKQHPV---YLWTLPMFHcngwcfPWT 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LTMncllfieLGGQNVLITNPrDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS-TLHLSAGGGMPvQQAVAE 343
Cdd:cd12118  195 VAA-------VGGTNVCLRKV-DAKAIYDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPhRVHVMTAGAPP-PAAVLA 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 344 RwVKLTGQYLLEGYGLTECAPLVSVNPhdidYHSGSIGLPvPSTEAKL-------------VDDEDNE----VPH-GEP- 404
Cdd:cd12118  266 K-MEELGFDVTHVYGLTETYGPATVCA----WKPEWDELP-TEERARLkarqgvryvgleeVDVLDPEtmkpVPRdGKTi 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 405 GELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVA 484
Cdd:cd12118  340 GEIVFRGNIVMKGYLKNPEATAEAFRGGWFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAA 419
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 485 AVGVPSGSSGEAVKIFV-VKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDeLPKSNVGKILRRELRD 551
Cdd:cd12118  420 VVARPDEKWGEVPCAFVeLKEGAKVTEEEIIAFCREHLAGFMVPKTVVFGE-LPKTSTGKIQKFVLRD 486
PRK09088 PRK09088
acyl-CoA synthetase; Validated
34-551 1.73e-68

acyl-CoA synthetase; Validated


Pssm-ID: 181644 [Multi-domain]  Cd Length: 488  Bit Score: 229.31  E-value: 1.73e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  34 RRYADQPAFVNM--GEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPR 111
Cdd:PRK09088   6 RLQPQRLAAVDLalGRRWTYAELDALVGRLAAVLR-RRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSAS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 112 ELEHQLNDSGAAAIVivsnfahtlekvvektqvkhviltrmGDQLSTAKGTLVnfvvkyvkrlvpkYHLPDAISFRRALH 191
Cdd:PRK09088  85 ELDALLQDAEPRLLL--------------------------GDDAVAAGRTDV-------------EDLAAFIASADALE 125
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 192 AGYRmQYVKPEIVSedlaFLQYTGGTTGVAKGAMLTHRNmlanLEQVNATYGPLLHPGKELVITA-LPLYHIFALTMNCL 270
Cdd:PRK09088 126 PADT-PSIPPERVS----LILFTSGTSGQPKGVMLSERN----LQQTAHNFGVLGRVDAHSSFLCdAPMFHIIGLITSVR 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 271 LFIELGGqNVLITNPRDIPGLVKELAKyPFTAMT---GVNTLFNALLNNKEFqqlDFSTL-HLSA--GGGMPvQQAVAER 344
Cdd:PRK09088 197 PVLAVGG-SILVSNGFEPKRTLGRLGD-PALGIThyfCVPQMAQAFRAQPGF---DAAALrHLTAlfTGGAP-HAAEDIL 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQYLLEGYGLTECAPL--VSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRP 422
Cdd:PRK09088 271 GWLDDGIPMVDGFGMSEAGTVfgMSVDCDVIRAKAGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRP 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 423 DATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV 501
Cdd:PRK09088 351 QATARAFtGDGWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAI 430
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489956626 502 VKKDPSLTEDALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK09088 431 VPADGAPLDLERIrSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLRD 481
benz_CoA_lig TIGR02262
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ...
21-551 3.08e-68

benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.


Pssm-ID: 274059 [Multi-domain]  Cd Length: 505  Bit Score: 228.95  E-value: 3.08e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   21 RYQSLIELFEHSVRR-YADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:TIGR02262   2 KYNAAEDLLDRNVVEgRGGKTAFIDDISSLSYGELEAQVRRLAAALRR-LGVKREERVLLLMLDGVDFPIAFLGAIRAGI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKT-QVKHVILTrmGDQLSTAKgTLVNFVVKYVKRLVPKY 178
Cdd:TIGR02262  81 VPVALNTLLTADDYAYMLEDSRARVVFVSGALLPVIKAALGKSpHLEHRVVV--GRPEAGEV-QLAELLATESEQFKPAA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  179 HLPDaisfrralhagyrmqyvkpeivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvnaTYG-PLLHPGK-ELVITA 256
Cdd:TIGR02262 158 TQAD------------------------DPAFWLYSSGSTGMPKGVVHTHSNPYWTAE----LYArNTLGIREdDVCFSA 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  257 LPLYHIFALTmNCLLFIELGGQNVLITNPRDIPGLV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGM 335
Cdd:TIGR02262 210 AKLFFAYGLG-NALTFPMSVGATTVLMGERPTPDAVfDRLRRHQPTIFYGVPTLYAAMLADPNLPSEDQVRLRLCTSAGE 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  336 PVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQV 414
Cdd:TIGR02262 289 ALPAEVGQRWQARFGVDIVDGIGSTEMLHIFLSNlPGDVRY--GTSGKPVPGYRLRLVGDGGQDVADGEPGELLISGPSS 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  415 MLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSG 494
Cdd:TIGR02262 367 ATMYWNNRAKSRDTFQGEWTRSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFEIESALIQHPAVLEAAVVGVADEDGL 446
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626  495 EAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:TIGR02262 447 IKPKAFVVlRPGQTALETELKEHVKDRLAPYKYPRWIVFVDDLPKTATGKIQRFKLRE 504
PRK06155 PRK06155
crotonobetaine/carnitine-CoA ligase; Provisional
23-552 4.01e-68

crotonobetaine/carnitine-CoA ligase; Provisional


Pssm-ID: 235719 [Multi-domain]  Cd Length: 542  Bit Score: 229.64  E-value: 4.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK06155  21 RTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAA-GVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEK-TQVKHVILTRMGDQLSTAKGtlvnfvVKYVKrLVPKYHLP 181
Cdd:PRK06155 100 PINTALRGPQLEHILRNSGARLLVVEAALLAALEAADPGdLPLPAVWLLDAPASVSVPAG------WSTAP-LPPLDAPA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 182 DAISFRRAlhagyrmqyvkpeivseDLAFLQYTGGTTGVAKGAMLTH-------RNMLANLEqvnatygplLHPGkELVI 254
Cdd:PRK06155 173 PAAAVQPG-----------------DTAAILYTSGTTGPSKGVCCPHaqfywwgRNSAEDLE---------IGAD-DVLY 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 255 TALPLYHIFALTMncllFIE--LGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:PRK06155 226 TTLPLFHTNALNA----FFQalLAGATYVLEPRFSASGFWPAVRRHGATVTYLLGAMVSILLSQPARESDRAHRVRVALG 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 333 GGMPVQQAVA--ERwvklTGQYLLEGYGLTEcAPLVSVNPHDIDyHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVR 410
Cdd:PRK06155 302 PGVPAALHAAfrER----FGVDLLDGYGSTE-TNFVIAVTHGSQ-RPGSMGRLAPGFEARVVDEHDQELPDGEPGELLLR 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 411 GPQ---VMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:PRK06155 376 ADEpfaFATGYFGMPEKTVEAWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAVFP 455
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 488 VPSGSSGEAVKIFVVKKD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06155 456 VPSELGEDEVMAAVVLRDgTALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLREQ 521
PRK07787 PRK07787
acyl-CoA synthetase; Validated
25-550 5.52e-68

acyl-CoA synthetase; Validated


Pssm-ID: 236096 [Multi-domain]  Cd Length: 471  Bit Score: 227.18  E-value: 5.52e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  25 LIELFEHSVRRYADQPAFVNMGE-VMTFRKLEERSRAFAAylqeglGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK07787   1 LASLNPAAVAAAADIADAVRIGGrVLSRSDLAGAATAVAE------RVAGARRVAVLATPTLATVLAVVGALIAGVPVVP 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 104 VNPLYTPRELEHQLNDSGAAAIvivsnfahtlekvvektqvkhviLTRMGDQLSTakgtlvnfvvkyvkrlvpkyhLPdA 183
Cdd:PRK07787  75 VPPDSGVAERRHILADSGAQAW-----------------------LGPAPDDPAG---------------------LP-H 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 184 ISFRraLHAgyRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpllHPGKELVITALPLYHIF 263
Cdd:PRK07787 110 VPVR--LHA--RSWHRYPEPDPDAPALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAWQ---WTADDVLVHGLPLFHVH 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 264 ALTMNCLLFIELGGQNVLITNPRdiPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLdFSTLHLSAGGGMPVQQAVAE 343
Cdd:PRK07787 183 GLVLGVLGPLRIGNRFVHTGRPT--PEAYAQALSEGGTLYFGVPTVWSRIAADPEAARA-LRGARLLVSGSAALPVPVFD 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 344 RWVKLTGQYLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTEAKLVDDEDNEVPH-GEP-GELCVRGPQVMLGYWQR 421
Cdd:PRK07787 260 RLAALTGHRPVERYGMTETLITLSTRA-DGERRPGWVGLPLAGVETRLVDEDGGPVPHdGETvGELQVRGPTLFDGYLNR 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 422 PDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKK-DMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKI 499
Cdd:PRK07787 339 PDATAAAFtADGWFRTGDVAVVDPDGMHRIVGREStDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIVA 418
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489956626 500 FVVKKDPSlTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07787 419 YVVGADDV-AADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLL 468
PRK13391 PRK13391
acyl-CoA synthetase; Provisional
33-551 3.76e-67

acyl-CoA synthetase; Provisional


Pssm-ID: 184022 [Multi-domain]  Cd Length: 511  Bit Score: 226.11  E-value: 3.76e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  33 VRRYADQPAFV--NMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTP 110
Cdd:PRK13391   7 AQTTPDKPAVImaSTGEVVTYRELDERSNRLAHLFRS-LGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTP 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 111 RELEHQLNDSGAAAiVIVSnfAHTLEKVVEKT-QVKHVILTRMGDqlstAKGTLVNFVvkyvkrlvpkyHLPDAISfrra 189
Cdd:PRK13391  86 AEAAYIVDDSGARA-LITS--AAKLDVARALLkQCPGVRHRLVLD----GDGELEGFV-----------GYAEAVA---- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 190 lhagyrmQYVKPEIVSEDL-AFLQYTGGTTGVAKGAmlthRNMLANLEQVNATygPLLHPGKELV--------ITALPLY 260
Cdd:PRK13391 144 -------GLPATPIADESLgTDMLYSSGTTGRPKGI----KRPLPEQPPDTPL--PLTAFLQRLWgfrsdmvyLSPAPLY 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 261 HIfALTMNCLLFIELGGQNVLITN--PRDIPGLVKelaKYPFTAMTGVNTLFNALLNNKEFQQL--DFSTLHLSAGGGMP 336
Cdd:PRK13391 211 HS-APQRAVMLVIRLGGTVIVMEHfdAEQYLALIE---EYGVTHTQLVPTMFSRMLKLPEEVRDkyDLSSLEVAIHAAAP 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 337 VQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStEAKLVDDEDNEVPHGEPGELCVRGPQvML 416
Cdd:PRK13391 287 CPPQVKEQMIDWWGPIIHEYYAATEGLGFTACDSEEWLAHPGTVGRAMFG-DLHILDDDGAELPPGEPGTIWFEGGR-PF 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 417 GYWQRPDATDEIIKD--GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSG 494
Cdd:PRK13391 365 EYLNDPAKTAEARHPdgTWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLG 444
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 495 EAVKIFVVKKDPSLTEDA----LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK13391 445 EEVKAVVQPVDGVDPGPAlaaeLIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLRD 505
caiC PRK08008
putative crotonobetaine/carnitine-CoA ligase; Validated
23-550 4.21e-67

putative crotonobetaine/carnitine-CoA ligase; Validated


Pssm-ID: 181195 [Multi-domain]  Cd Length: 517  Bit Score: 226.10  E-value: 4.21e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFV---NMGEVMTF--RKL-EERSRAFAAYLQegLGLQKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK08008   7 QHLRQMWDDLADVYGHKTALIfesSGGVVRRYsyLELnEEINRTANLFYS--LGIRKGDKVALHLDNCPEFIFCWFGLAK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEK--TQVKHVILTRMGdqLSTAKGTlVNFvvkyvKRL 174
Cdd:PRK08008  85 IGAIMVPINARLLREESAWILQNSQASLLVTSAQFYPMYRQIQQEdaTPLRHICLTRVA--LPADDGV-SSF-----TQL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 175 vpkyhlpdaisfrRALHAGyRMQYVKPeIVSEDLAFLQYTGGTTGVAKGAMLTHRNML-ANLE---QVNATYgpllhpgK 250
Cdd:PRK08008 157 -------------KAQQPA-TLCYAPP-LSTDDTAEILFTSGTTSRPKGVVITHYNLRfAGYYsawQCALRD-------D 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 251 ELVITALPLYHI-FALTMNCLLFiELGGQNVLI-----------------TNPRDIPGLVKELAKYPFTAMTgvntlfna 312
Cdd:PRK08008 215 DVYLTVMPAFHIdCQCTAAMAAF-SAGATFVLLekysarafwgqvckyraTITECIPMMIRTLMVQPPSAND-------- 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 313 llNNKEFQQLDFsTLHLSAGGgmpvQQAVAERWvkltGQYLLEGYGLTECapLVSV---NPHDiDYHSGSIGLPVPSTEA 389
Cdd:PRK08008 286 --RQHCLREVMF-YLNLSDQE----KDAFEERF----GVRLLTSYGMTET--IVGIigdRPGD-KRRWPSIGRPGFCYEA 351
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 390 KLVDDEDNEVPHGEPGELCVRG---PQVMLGYWQRPDATDEIIK-DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNV 465
Cdd:PRK08008 352 EIRDDHNRPLPAGEIGEICIKGvpgKTIFKEYYLDPKATAKVLEaDGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGENV 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 466 YPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKI 544
Cdd:PRK08008 432 SCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEgETLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKI 511

                 ....*.
gi 489956626 545 LRRELR 550
Cdd:PRK08008 512 IKKNLK 517
FAAL cd05931
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...
34-551 7.87e-67

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.


Pssm-ID: 341254 [Multi-domain]  Cd Length: 547  Bit Score: 226.35  E-value: 7.87e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  34 RRYADQPAFVNMG---------EVMTFRKLEERSRAFAAYLQEGLGlqKGDRVALMMPNLLQYPVALFGILRAGMIVVnv 104
Cdd:cd05931    1 RRAAARPDRPAYTflddeggreETLTYAELDRRARAIAARLQAVGK--PGDRVLLLAPPGLDFVAAFLGCLYAGAIAV-- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 105 nPLYTPRELEHQ------LNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLVnfvvkyvkrlvpky 178
Cdd:cd05931   77 -PLPPPTPGRHAerlaaiLADAGPRVVLTTAAALAAVRAFAASRPAAGTPRLLVVDLLPDTSAADW-------------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 179 hlpdaisfrralhagyrmqyVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpllHPGKELVITALP 258
Cdd:cd05931  142 --------------------PPPSPDPDDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYG---LDPGDVVVSWLP 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 259 LYHIFALTMNCLLFIELGGQNVLITnPRDI---PGL-VKELAKYPFTAMTGVNtlFnAL------LNNKEFQQLDFSTLH 328
Cdd:cd05931  199 LYHDMGLIGGLLTPLYSGGPSVLMS-PAAFlrrPLRwLRLISRYRATISAAPN--F-AYdlcvrrVRDEDLEGLDLSSWR 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 LSAGGGMPVQQAVAERWVKLTGQY------LLEGYGLTECAPLVSVNPH---------------------DIDYHSG--- 378
Cdd:cd05931  275 VALNGAEPVRPATLRRFAEAFAPFgfrpeaFRPSYGLAEATLFVSGGPPgtgpvvlrvdrdalagravavAADDPAArel 354
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 379 -SIGLPVPSTEAKLVDDEDN-EVPHGEPGELCVRGPQVMLGYWQRPDATDEIIK-------DGWLHTGDIAVMDDeGFLR 449
Cdd:cd05931  355 vSCGRPLPDQEVRIVDPETGrELPDGEVGEIWVRGPSVASGYWGRPEATAETFGalaatdeGGWLRTGDLGFLHD-GELY 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 450 IVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLE---VAAVGVPSGSSGEAVKIFVVKKDP-SLTEDALITFCRRQL-TGY 524
Cdd:cd05931  434 ITGRLKDLIIVRGRNHYPQDIEATAEEAHPALRpgcVAAFSVPDDGEERLVVVAEVERGAdPADLAAIAAAIRAAVaREH 513
                        570       580       590
                 ....*....|....*....|....*....|.
gi 489956626 525 KVP----KLVEfRDELPKSNVGKILRRELRD 551
Cdd:cd05931  514 GVApadvVLVR-PGSIPRTSSGKIQRRACRA 543
PRK12406 PRK12406
long-chain-fatty-acid--CoA ligase; Provisional
48-551 8.69e-66

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 183506 [Multi-domain]  Cd Length: 509  Bit Score: 222.65  E-value: 8.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  48 VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVI 127
Cdd:PRK12406  11 RRSFDELAQRAARAAGGLAA-LGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLIA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 128 VSNFAHTLEKVVektqvkhviltrmgdqlstAKGTLVnFVVKYVKRLVPKYHLPDAISFRRALHAGYR--MQYVKP--EI 203
Cdd:PRK12406  90 HADLLHGLASAL-------------------PAGVTV-LSVPTPPEIAAAYRISPALLTPPAGAIDWEgwLAQQEPydGP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 VSEDLAFLQYTGGTTGVAKGamlTHRN-----MLANLEQVNAT-YGplLHPGKELVITAlPLYH----IFALTMncllfI 273
Cdd:PRK12406 150 PVPQPQSMIYTSGTTGHPKG---VRRAaptpeQAAAAEQMRALiYG--LKPGIRALLTG-PLYHsapnAYGLRA-----G 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 274 ELGGqnVLITNPR-DIPGLVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTL----HLSAGGGMPVQQAVAERWv 346
Cdd:PRK12406 219 RLGG--VLVLQPRfDPEELLQLIERHRITHMHMVPTMFIRLLKlpEEVRAKYDVSSLrhviHAAAPCPADVKRAMIEWW- 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 347 kltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVML-GYWQRPDAT 425
Cdd:PRK12406 296 ---GPVIYEYYGSTESGAVTFATSEDALSHPGTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPEKR 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 DEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVkIFVVKKD 505
Cdd:PRK12406 373 AEIDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEAL-MAVVEPQ 451
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 489956626 506 P--SLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK12406 452 PgaTLDEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRD 499
LC_FACL_like cd05914
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...
46-546 2.10e-64

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341240 [Multi-domain]  Cd Length: 463  Bit Score: 217.70  E-value: 2.10e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05914    5 GEPLTYKDLADNIAKFALLLKIN-GVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 vivsnfahtlekvvektqvkhviltrmgdqlstakgtlvnFVVKyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivS 205
Cdd:cd05914   84 ----------------------------------------FVSD-----------------------------------E 88
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATygPLLHPGkELVITALPLYHIFALTMNCLLFIELGGQNVLITNP 285
Cdd:cd05914   89 DDVALINYTSGTTGNSKGVMLTYRNIVSNVDGVKEV--VLLGKG-DKILSILPLHHIYPLTFTLLLPLLNGAHVVFLDKI 165
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 286 RdiPGLVKELAKYPFTAMTGVNTLF-----------------------NALLNNKEFQQLDFSTLHLSAGG--------G 334
Cdd:cd05914  166 P--SAKIIALAFAQVTPTLGVPVPLviekifkmdiipkltlkkfkfklAKKINNRKIRKLAFKKVHEAFGGnikefvigG 243
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 335 MPVQQAVAERWVKLTGQYLlEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKlVDDEDnevPHGEPGELCVRGPQV 414
Cdd:cd05914  244 AKINPDVEEFLRTIGFPYT-IGYGMTETAPIISYSPPN-RIRLGSAGKVIDGVEVR-IDSPD---PATGEGEIIVRGPNV 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 415 MLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILV-SGFNVYPNEIEDVVMQHSGVLEvAAVGVPSGS 492
Cdd:cd05914  318 MKGYYKNPEATAEAFdKDGWFHTGDLGKIDAEGYLYIRGRKKEMIVLsSGKNIYPEEIEAKINNMPFVLE-SLVVVQEKK 396
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489956626 493 S---------GEAVKIFVVKKDPSLTEDALITFCRRQLTGY-KVPKLVEFRDELPKSNVGKILR 546
Cdd:cd05914  397 LvalayidpdFLDVKALKQRNIIDAIKWEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKR 460
PRK06145 PRK06145
acyl-CoA synthetase; Validated
34-552 7.27e-64

acyl-CoA synthetase; Validated


Pssm-ID: 102207 [Multi-domain]  Cd Length: 497  Bit Score: 217.06  E-value: 7.27e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  34 RRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPREL 113
Cdd:PRK06145  13 RRTPDRAALVYRDQEISYAEFHQRILQAAGMLH-ARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 114 EHQLNDSGAAAIVIVSNFAhtlekVVEKTQVKHVILTRMGDQLSTAKGtlvnfvvkyvkrlvpkyhlpdaisfrrALHAG 193
Cdd:PRK06145  92 AYILGDAGAKLLLVDEEFD-----AIVALETPKIVIDAAAQADSRRLA---------------------------QGGLE 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 194 YRMQYVKPEivsEDLAFLQYTGGTTGVAKGAMLTHRNM-LANLEQVNATygPLLHPGKELVITalPLYHIFALTMNCLLF 272
Cdd:PRK06145 140 IPPQAAVAP---TDLVRLMYTSGTTDRPKGVMHSYGNLhWKSIDHVIAL--GLTASERLLVVG--PLYHVGAFDLPGIAV 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 273 IELGGQnVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPV-QQAVAERWVKLTGQ 351
Cdd:PRK06145 213 LWVGGT-LRIHREFDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKTpESRIRDFTRVFTRA 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 352 YLLEGYGLTE-CAPLVSVNP-HDIDyHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEII 429
Cdd:PRK06145 292 RYIDAYGLTEtCSGDTLMEAgREIE-KIGSTGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAF 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 430 KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGE-AVKIFVVKKDPSL 508
Cdd:PRK06145 371 YGDWFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGErITAVVVLNPGATL 450
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 489956626 509 TEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06145 451 TLEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDE 494
PRK07788 PRK07788
acyl-CoA synthetase; Validated
20-551 1.45e-63

acyl-CoA synthetase; Validated


Pssm-ID: 236097 [Multi-domain]  Cd Length: 549  Bit Score: 217.49  E-value: 1.45e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  20 DRYQSLIELFEHSVRRYADQPAFVN-MGEvMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAG 98
Cdd:PRK07788  46 RRYGPFAGLVAHAARRAPDRAALIDeRGT-LTYAELDEQSNALARGLLA-LGVRAGDGVAVLARNHRGFVLALYAAGKVG 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  99 MIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKG--TLVNFVVKYVKRLVP 176
Cdd:PRK07788 124 ARIILLNTGFSGPQLAEVAAREGVKALVYDDEFTDLLSALPPDLGRLRAWGGNPDDDEPSGSTdeTLDDLIAGSSTAPLP 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 177 KyhlpdaisFRRalHAGyrmqyvkpeivsedlaFLQYTGGTTGVAKGAMLTHRNMLANLEQVnATYGPLlhPGKELVITA 256
Cdd:PRK07788 204 K--------PPK--PGG----------------IVILTSGTTGTPKGAPRPEPSPLAPLAGL-LSRVPF--RAGETTLLP 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 257 LPLYHIFALtMNCLLFIELGgqNVLITNPR-DIPGLVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGG 333
Cdd:PRK07788 255 APMFHATGW-AHLTLAMALG--STVVLRRRfDPEATLEDIAKHKATALVVVPVMLSRILDlgPEVLAKYDTSSLKIIFVS 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 334 GMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQ 413
Cdd:PRK07788 332 GSALSPELATRALEAFGPVLYNLYGSTEVAFATIATPEDLAEAPGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGF 411
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 414 VMLGYwqrPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSS 493
Cdd:PRK07788 412 PFEGY---TDGRDKQIIDGLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDEEF 488
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 494 GEAVKIFVVKKDPS-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK07788 489 GQRLRAFVVKAPGAaLDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547
A_NRPS cd05930
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...
37-549 1.26e-62

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341253 [Multi-domain]  Cd Length: 444  Bit Score: 212.39  E-value: 1.26e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  37 ADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYtPRE-LEH 115
Cdd:cd05930    1 PDAVAVVDGDQSLTYAELDARANRLARYLRE-RGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSY-PAErLAY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 116 QLNDSGAaaivivsnfahtlekvvektqvkHVILTRmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyr 195
Cdd:cd05930   79 ILEDSGA-----------------------KLVLTD-------------------------------------------- 91
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 196 mqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYgPLLHPGKELVITALP----LYHIFALTMNcll 271
Cdd:cd05930   92 ---------PDDLAYVIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAY-PLTPGDRVLQFTSFSfdvsVWEIFGALLA--- 158
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 272 fielGGQNVLITN--PRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQqlDFSTLHLSAGGGMPVQQAVAERWVKL- 348
Cdd:cd05930  159 ----GATLVVLPEevRKDPEALADLLAEEGITVLHLTPSLLRLLLQELELA--ALPSLRLVLVGGEALPPDLVRRWRELl 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 349 TGQYLLEGYGLTECAPLVS---VNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDAT 425
Cdd:cd05930  233 PGARLVNLYGPTEATVDATyyrVPPDDEEDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELT 312
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 DE-IIKD-----GWLH-TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVK 498
Cdd:cd05930  313 AErFVPNpfgpgERMYrTGDLVRWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEKRLV 392
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489956626 499 IFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05930  393 AYVVpDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
20-553 6.98e-62

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 220.95  E-value: 6.98e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   20 DRYQSLIELFEHSVRRYADQPAFVN-MGEVMTFRKLEERSRAFAAYLQEGLGLQKgdRVALMMPNLLQYPVALFGILRAG 98
Cdd:PRK08633  612 EALPPLAEAWIDTAKRNWSRLAVADsTGGELSYGKALTGALALARLLKRELKDEE--NVGILLPPSVAGALANLALLLAG 689
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   99 MIVVNVNplYTprelehqlndSGAAAivivsnfahtLEKVVEKTQVKHVILTRMGDQLSTAKGTLVNFV----VKYVKRL 174
Cdd:PRK08633  690 KVPVNLN--YT----------ASEAA----------LKSAIEQAQIKTVITSRKFLEKLKNKGFDLELPenvkVIYLEDL 747
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  175 VPKYHLPDAIsfrRALHAGYRM------QYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNAtygpLLHP 248
Cdd:PRK08633  748 KAKISKVDKL---TALLAARLLparllkRLYGPTFKPDDTATIIFSSGSEGEPKGVMLSHHNILSNIEQISD----VFNL 820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  249 GKELVI-TALPLYHIFALTMNCLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL 327
Cdd:PRK08633  821 RNDDVIlSSLPFFHSFGLTVTLWLPLLEGIKVVYHPDPTDALGIAKLVAKHRATILLGTPTFLRLYLRNKKLHPLMFASL 900
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  328 HLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDI---DYHS------GSIGLPVPSTEAKLVDDED-N 397
Cdd:PRK08633  901 RLVVAGAEKLKPEVADAFEEKFGIRILEGYGATETSPVASVNLPDVlaaDFKRqtgskeGSVGMPLPGVAVRIVDPETfE 980
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  398 EVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKD----GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:PRK08633  981 ELPPGEDGLILIGGPQVMKGYLGDPEKTAEVIKDidgiGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEE 1060
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  474 VMQ--HSGVLEVAAVGVPSGSSGEavKIFVVKKDPSLTEDALitfcRRQLTGYKVPKLVEFR-----DELPKSNVGKILR 546
Cdd:PRK08633 1061 LAKalGGEEVVFAVTAVPDEKKGE--KLVVLHTCGAEDVEEL----KRAIKESGLPNLWKPSryfkvEALPLLGSGKLDL 1134

                  ....*..
gi 489956626  547 RELRDEA 553
Cdd:PRK08633 1135 KGLKELA 1141
menE TIGR01923
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ...
50-549 1.18e-61

O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 162605 [Multi-domain]  Cd Length: 436  Bit Score: 209.61  E-value: 1.18e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   50 TFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGaaaivivs 129
Cdd:TIGR01923   1 TWQDLDCEAAHLAKALKAQ-GIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLEDLD-------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  130 nfahtlekvvektqvKHVILTrmgDQLSTAKGTlvnfvvkyvkrlvpkyhlpDAISFRRALHAGYRMQYVKPEIVSEDLA 209
Cdd:TIGR01923  72 ---------------VQLLLT---DSLLEEKDF-------------------QADSLDRIEAAGRYETSLSASFNMDQIA 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVItALPLYHIFALTMncLLFIELGGQNVLITNPRDip 289
Cdd:TIGR01923 115 TLMFTSGTTGKPKAVPHTFRNHYASAVGSKENLG--FTEDDNWLL-SLPLYHISGLSI--LFRWLIEGATLRIVDKFN-- 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  290 GLVKELAKYPFTAMTGVNTLFNALLNnkefQQLDFSTLHLSAGGGMPVQQAVAERWVKLtGQYLLEGYGLTECAPLVSVN 369
Cdd:TIGR01923 188 QLLEMIANERVTHISLVPTQLNRLLD----EGGHNENLRKILLGGSAIPAPLIEEAQQY-GLPIYLSYGMTETCSQVTTA 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  370 PHDIDYHSGSIGLPVPSTEAKLVDDEDNEVphgepGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLR 449
Cdd:TIGR01923 263 TPEMLHARPDVGRPLAGREIKIKVDNKEGH-----GEIMVKGANLMKGYLYQGELTPAFEQQGWFNTGDIGELDGEGFLY 337
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  450 IVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEA-VKIFVVKKDPSLTEdaLITFCRRQLTGYKVPK 528
Cdd:TIGR01923 338 VLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWGQVpVAYIVSESDISQAK--LIAYLTEKLAKYKVPI 415
                         490       500
                  ....*....|....*....|.
gi 489956626  529 LVEFRDELPKSNVGKILRREL 549
Cdd:TIGR01923 416 AFEKLDELPYNASGKILRNQL 436
MACS_like_4 cd05969
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...
50-550 2.67e-61

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.


Pssm-ID: 341273 [Multi-domain]  Cd Length: 442  Bit Score: 208.90  E-value: 2.67e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAAAIV 126
Cdd:cd05969    2 TFAQLKVLSARFANVLKS-LGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVIC---PLFSafgPEAIRDRLENSEAKVLI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 127 ivsnfahTLEKVVEKTQVkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivsE 206
Cdd:cd05969   78 -------TTEELYERTDP-------------------------------------------------------------E 89
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnlEQVNATYGPLLHPGKELVITALP------LYHIFALTMNcllfielGGQNV 280
Cdd:cd05969   90 DPTLLHYTSGTTGTPKGVLHVHDAMIF--YYFTGKYVLDLHPDDIYWCTADPgwvtgtVYGIWAPWLN-------GVTNV 160
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 281 LITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLHLSAGGGMPVQQAVAeRW-VKLTGQYLLEGY 357
Cdd:cd05969  161 VYEGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAI-RWgMEVFGVPIHDTW 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 358 GLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRG--PQVMLGYWQRPDATDEIIKDGWLH 435
Cdd:cd05969  240 WQTETGSIMIANYPCMPIKPGSMGKPLPGVKAAVVDENGNELPPGTKGILALKPgwPSMFRGIWNDEERYKNSFIDGWYL 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 436 TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTE---D 511
Cdd:cd05969  320 TGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISlKEGFEPSDelkE 399
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 489956626 512 ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05969  400 EIINFVRQKLGAHVAPREIEFVDNLPKTRSGKIMRRVLK 438
PRK07798 PRK07798
acyl-CoA synthetase; Validated
28-543 3.50e-61

acyl-CoA synthetase; Validated


Pssm-ID: 236100 [Multi-domain]  Cd Length: 533  Bit Score: 210.90  E-value: 3.50e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  28 LFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:PRK07798   8 LFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIA-QGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYR 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 108 YTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKT-QVKHVIltRMGDQLSTAkgtlvnfvvkyvkrlvpkyHLPDAISF 186
Cdd:PRK07798  87 YVEDELRYLLDDSDAVALVYEREFAPRVAEVLPRLpKLRTLV--VVEDGSGND-------------------LLPGAVDY 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 RRALHAGyrmqyvKPEIV----SEDLAFLQYTGGTTGVAKGAMLTHRNM-LANLEQVNATYGPLLHPGKELVITAL---- 257
Cdd:PRK07798 146 EDALAAG------SPERDfgerSPDDLYLLYTGGTTGMPKGVMWRQEDIfRVLLGGRDFATGEPIEDEEELAKRAAagpg 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 258 -------PLYHIFAL--TMNCLLFielGGQNVLITNPR-DIPGLVKELAKYPFTAMTGVN-----TLFNALLNNKEFqql 322
Cdd:PRK07798 220 mrrfpapPLMHGAGQwaAFAALFS---GQTVVLLPDVRfDADEVWRTIEREKVNVITIVGdamarPLLDALEARGPY--- 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 323 DFSTLHLSAGGGMPVQQAVAERWVKLTGQ-YLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPV-PSTeaKLVDDEDNEVP 400
Cdd:PRK07798 294 DLSSLFAIASGGALFSPSVKEALLELLPNvVLTDSIGSSETGFGGSGTVAKGAVHTGGPRFTIgPRT--VVLDEDGNPVE 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 401 --HGEPGELCVRGPqVMLGYWQRPDATDEIIK--DG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:PRK07798 372 pgSGEIGWIARRGH-IPLGYYKDPEKTAETFPtiDGvrYAIPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEAL 450
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 475 MQHSGVLEVAAVGVPSGSSGEAVkIFVVKKDP--SLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK07798 451 KAHPDVADALVVGVPDERWGQEV-VAVVQLREgaRPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGK 520
FACL_like_4 cd05944
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
205-553 5.23e-61

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341266 [Multi-domain]  Cd Length: 359  Bit Score: 205.41  E-value: 5.23e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 SEDLAFLQYTGGTTGVAKGAMLTHRNMLANLE--QVNATYGPllhpgKELVITALPLYHIFALTMNCLLFIELGGQNVLI 282
Cdd:cd05944    1 SDDVAAYFHTGGTTGTPKLAQHTHSNEVYNAWmlALNSLFDP-----DDVLLCGLPLFHVNGSVVTLLTPLASGAHVVLA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 TnP---RDiPGLVKEL----AKYPFTAMTGVNTLFNALLNNKEfqQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLE 355
Cdd:cd05944   76 G-PagyRN-PGLFDNFwklvERYRITSLSTVPTVYAALLQVPV--NADISSLRFAMSGAAPLPVELRARFEDATGLPVVE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 356 GYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAK-LVDDEDNEVPH----GEPGELCVRGPQVMLGYWQRPDATDEIIK 430
Cdd:cd05944  152 GYGLTEATCLVAVNPPDGPKRPGSVGLRLPYARVRiKVLDGVGRLLRdcapDEVGEICVAGPGVFGGYLYTEGNKNAFVA 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 431 DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV-VKKDPSLT 509
Cdd:cd05944  232 DGWLNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVqLKPGAVVE 311
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 489956626 510 EDALITFCRRQLTGY-KVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05944  312 EEELLAWARDHVPERaAVPKHIEVLEELPVTAVGKVFKPALRADA 356
PRK13295 PRK13295
cyclohexanecarboxylate-CoA ligase; Reviewed
29-555 7.12e-61

cyclohexanecarboxylate-CoA ligase; Reviewed


Pssm-ID: 171961 [Multi-domain]  Cd Length: 547  Bit Score: 210.29  E-value: 7.12e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  29 FEHSVRRYADQPAFVNM----GEV--MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK13295  30 LDACVASCPDKTAVTAVrlgtGAPrrFTYRELAALVDRVAVGLAR-LGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLN 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 103 NVNPLYTPRELEHQLNDSGAAAIVIVS---NFAHtlEKVVEKTQ-----VKHVILTRMGDQLSTAKgtlvnfvvkyvkrl 174
Cdd:PRK13295 109 PLMPIFRERELSFMLKHAESKVLVVPKtfrGFDH--AAMARRLRpelpaLRHVVVVGGDGADSFEA-------------- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 175 vpkyHLPDAiSFRRALHAGYRMQYVKPEivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqvNATYGPLLHPGKELVI 254
Cdd:PRK13295 173 ----LLITP-AWEQEPDAPAILARLRPG--PDDVTQLIYTSGTTGEPKGVMHTANTLMAN----IVPYAERLGLGADDVI 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 255 -TALPLYHIFALTMNCLLFIELGGQNVL--ITNPRDIPGLVKE------LAKYPFTAmtgvntlfnALLNNKEFQQLDFS 325
Cdd:PRK13295 242 lMASPMAHQTGFMYGLMMPVMLGATAVLqdIWDPARAAELIRTegvtftMASTPFLT---------DLTRAVKESGRPVS 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 326 TLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYH-SGSIGLPVPSTEAKLVDDEDNEVPHGEP 404
Cdd:PRK13295 313 SLRTFLCAGAPIPGALVERARAALGAKIVSAWGMTENGAVTLTKLDDPDERaSTTDGCPLPGVEVRVVDADGAPLPAGQI 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 405 GELCVRGPQVMLGYWQRPD--ATDEiikDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLE 482
Cdd:PRK13295 393 GRLQVRGCSNFGGYLKRPQlnGTDA---DGWFDTGDLARIDADGYIRISGRSKDVIIRGGENIPVVEIEALLYRHPAIAQ 469
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489956626 483 VAAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQ-LTGYKVPKLVEFRDELPKSNVGKILRRELRDEARA 555
Cdd:PRK13295 470 VAIVAYPDERLGERACAFVVpRPGQSLDFEEMVEFLKAQkVAKQYIPERLVVRDALPRTPSGKIQKFRLREMLRG 544
CBAL cd05923
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...
23-549 1.25e-60

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.


Pssm-ID: 341247 [Multi-domain]  Cd Length: 493  Bit Score: 208.52  E-value: 1.25e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFVNM--GEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMI 100
Cdd:cd05923    1 QTVFEMLRRAASRAPDACAIADParGLRLTYSELRARIEAVAARLHA-RGLRPGQRVAVVLPNSVEAVIALLALHRLGAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 101 VVNVNPLYTPRELEhQLNDSGAAAIVIVSNFAhtleKVVEKTQVKHVILTRMGDQLSTakGTLVNFvvkyvkrlvpkyhl 180
Cdd:cd05923   80 PALINPRLKAAELA-ELIERGEMTAAVIAVDA----QVMDAIFQSGVRVLALSDLVGL--GEPESA-------------- 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 181 PDAISFRralhagyrmqyvKPEIvsEDLAFLQYTGGTTGVAKGAMLTHRnmlANLEQV--NATYGPLLHPGKELVITALP 258
Cdd:cd05923  139 GPLIEDP------------PREP--EQPAFVFYTSGTTGLPKGAVIPQR---AAESRVlfMSTQAGLRHGRHNVVLGLMP 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 259 LYHI---FALTMNCLLFielGGQNVLIT--NPRDIPGLVKELAkypFTAMTGVNTLFNALLNNKEFQQLDFSTL-HLS-A 331
Cdd:cd05923  202 LYHVigfFAVLVAALAL---DGTYVVVEefDPADALKLIEQER---VTSLFATPTHLDALAAAAEFAGLKLSSLrHVTfA 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 332 GGGMPvqQAVAERWVKLTGQYLLEGYGLTECAPLVsvnpHDIDYHSGSIGLPVPSTEAKLV---DDEDNEVPHGEPGELC 408
Cdd:cd05923  276 GATMP--DAVLERVNQHLPGEKVNIYGTTEAMNSL----YMRDARTGTEMRPGFFSEVRIVrigGSPDEALANGEEGELI 349
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 409 VR--GPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAV 486
Cdd:cd05923  350 VAaaADAAFTGYLNQPEATAKKLQDGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVI 429
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489956626 487 GVPSGSSGEAVKIFVVKKDPSLTEDALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05923  430 GVADERWGQSVTACVVPREGTLSADELDQFCRaSELADFKRPRRYFFLDELPKNAMNKVLRRQL 493
MACS_AAE_MA_like cd05970
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...
12-551 1.45e-60

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.


Pssm-ID: 341274 [Multi-domain]  Cd Length: 537  Bit Score: 209.27  E-value: 1.45e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  12 DVPAEINPDRyQSLIELFEHSVRRyadqpafvnmgeVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVAL 91
Cdd:cd05970   24 DAMAKEYPDK-LALVWCDDAGEER------------IFTFAELADYSDKTANFFKA-MGIGKGDTVMLTLKRRYEFWYSL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  92 FGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS--NFAHTLEKVVEKTQVKHViLTRMGDQLSTAkgtLVNFVvK 169
Cdd:cd05970   90 LALHKLGAIAIPATHQLTAKDIVYRIESADIKMIVAIAedNIPEEIEKAAPECPSKPK-LVWVGDPVPEG---WIDFR-K 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 170 YVKRLVPKYHLPDAISfrralhagyrmqyvkpEIVSEDLAFLQYTGGTTGVAKgaMLTHrnmlanleqvNATYgPLLHpg 249
Cdd:cd05970  165 LIKNASPDFERPTANS----------------YPCGEDILLVYFSSGTTGMPK--MVEH----------DFTY-PLGH-- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 250 kelVITAL--------PLYHIFALT-----MNCLLFIE-LGGQNVLITN-PRDIP-GLVKELAKYPFTAMTGVNTLFNAL 313
Cdd:cd05970  214 ---IVTAKywqnvregGLHLTVADTgwgkaVWGKIYGQwIAGAAVFVYDyDKFDPkALLEKLSKYGVTTFCAPPTIYRFL 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 314 LNNKeFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHdIDYHSGSIGLPVPSTEAKLVD 393
Cdd:cd05970  291 IRED-LSRYDLSSLRYCTTAGEALNPEVFNTFKEKTGIKLMEGFGQTETTLTIATFPW-MEPKPGSMGKPAPGYEIDLID 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 394 DEDNEVPHGEPGELCVR---GPQVML--GYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:cd05970  369 REGRSCEAGEEGEIVIRtskGKPVGLfgGYYKDAEKTAEVWHDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPF 448
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 469 EIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-----KKDPSLTEDaLITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:cd05970  449 EVESALIQHPAVLECAVTGVPDPIRGQVVKATIVlakgyEPSEELKKE-LQDHVKKVTAPYKYPRIVEFVDELPKTISGK 527

                 ....*...
gi 489956626 544 ILRRELRD 551
Cdd:cd05970  528 IRRVEIRE 535
PRK08162 PRK08162
acyl-CoA synthetase; Validated
18-555 3.29e-59

acyl-CoA synthetase; Validated


Pssm-ID: 236169 [Multi-domain]  Cd Length: 545  Bit Score: 205.95  E-value: 3.29e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  18 NPDRYQSL--IELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGIL 95
Cdd:PRK08162  11 NAANYVPLtpLSFLERAAEVYPDRPAVIHGDRRRTWAETYARCRRLASALA-RRGIGRGDTVAVLLPNIPAMVEAHFGVP 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  96 RAGMIVVNVNPLYTPRELEHQLnDSGAAAIVIV-SNFAHTLEKVVEKTQVKHVIltrmgdqlstakgtlvnfVVKYVKRL 174
Cdd:PRK08162  90 MAGAVLNTLNTRLDAASIAFML-RHGEAKVLIVdTEFAEVAREALALLPGPKPL------------------VIDVDDPE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 175 VPKYHLPDAISFRRALHAGY-RMQYVKPEIVSEDLAfLQYTGGTTGVAKGAMLTHR----NMLANleQVNATYGPllHPg 249
Cdd:PRK08162 151 YPGGRFIGALDYEAFLASGDpDFAWTLPADEWDAIA-LNYTSGTTGNPKGVVYHHRgaylNALSN--ILAWGMPK--HP- 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 250 keLVITALPLYHI----FALTMNCLlfielGGQNVLItnpRDI-PGLVKEL-AKYPFTAMTGVNTLFNALLNN-KEFQQ- 321
Cdd:PRK08162 225 --VYLWTLPMFHCngwcFPWTVAAR-----AGTNVCL---RKVdPKLIFDLiREHGVTHYCGAPIVLSALINApAEWRAg 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 322 LDFSTLHLSAGGGMP--VQQAVAERWVKLTgqyllEGYGLTECAPLVSVNPHDIDYHSGSI----------GLPVPSTEA 389
Cdd:PRK08162 295 IDHPVHAMVAGAAPPaaVIAKMEEIGFDLT-----HVYGLTETYGPATVCAWQPEWDALPLderaqlkarqGVRYPLQEG 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 390 KLVDDEDN--EVPH-GEP-GELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNV 465
Cdd:PRK08162 370 VTVLDPDTmqPVPAdGETiGEIMFRGNIVMKGYLKNPKATEEAFAGGWFHTGDLAVLHPDGYIKIKDRSKDIIISGGENI 449
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 466 YPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV-VKKDPSLTEDALITFCRRQLTGYKVPKLVEFrDELPKSNVGKI 544
Cdd:PRK08162 450 SSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVeLKDGASATEEEIIAHCREHLAGFKVPKAVVF-GELPKTSTGKI 528
                        570
                 ....*....|.
gi 489956626 545 LRRELRDEARA 555
Cdd:PRK08162 529 QKFVLREQAKS 539
MACS_euk cd05928
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...
47-552 1.90e-57

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.


Pssm-ID: 341251 [Multi-domain]  Cd Length: 530  Bit Score: 200.77  E-value: 1.90e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  47 EVM-TFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05928   39 EVKwSFRELGSLSRKAANVLSGACGLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIVSNFAHTLEKVVEKTQvkhviltrmgdQLSTakgtlvnfvvkyvKRLVPKYHLPDAISFRRAL-HAGYRMQYVKPEiv 204
Cdd:cd05928  119 VTSDELAPEVDSVASECP-----------SLKT-------------KLLVSEKSRDGWLNFKELLnEASTEHHCVETG-- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 SEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeQVNATYgpllhpgkelvITALPLYHIF--------ALTMNCLLFIE-L 275
Cdd:cd05928  173 SQEPMAIYFTSGTTGSPKMAEHSHSSLGLGL-KVNGRY-----------WLDLTASDIMwntsdtgwIKSAWSSLFEPwI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 276 GGQNVLITN-PR-DIPGLVKELAKYPFTAMTGVNTLFNALLNNkEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYL 353
Cdd:cd05928  241 QGACVFVHHlPRfDPLVILKTLSSYPITTFCGAPTVYRMLVQQ-DLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGLDI 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 354 LEGYGLTECApLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVR-GPQ----VMLGYWQRPDATDEI 428
Cdd:cd05928  320 YEGYGQTETG-LICANFKGMKIKPGSMGKASPPYDVQIIDDNGNVLPPGTEGDIGIRvKPIrpfgLFSGYVDNPEKTAAT 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 429 IKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSL 508
Cdd:cd05928  399 IRGDFYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVLAPQFL 478
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 489956626 509 TED------ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:cd05928  479 SHDpeqltkELQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDK 528
23DHB-AMP_lg cd05920
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...
23-549 2.49e-57

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.


Pssm-ID: 341244 [Multi-domain]  Cd Length: 482  Bit Score: 199.09  E-value: 2.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05920   15 EPLGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLR-GLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVPV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 103 NVNPLYTPRELEHQLNDSGAAAIVIVsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvKRLVPKYHLPD 182
Cdd:cd05920   94 LALPSHRRSELSAFCAHAEAVAYIVP-------------------------------------------DRHAGFDHRAL 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 183 AISFRRALhagyrmqyvkPEIvsedlAFLQYTGGTTGVAKGAMLTHR----NMLANLEqvnatygpLLHPGKELV-ITAL 257
Cdd:cd05920  131 ARELAESI----------PEV-----ALFLLSGGTTGTPKLIPRTHNdyayNVRASAE--------VCGLDQDTVyLAVL 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 258 PLYHIFALT----MNCLLFielGGQNVLITNPRdiPGLVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:cd05920  188 PAAHNFPLAcpgvLGTLLA---GGRVVLAPDPS--PDAAFPLiEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQV 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 333 GGMPVQQAVAERWVKLTGQYLLEGYGLTEcaPLVSV----NPHDIDYHSGsiGLPV-PSTEAKLVDDEDNEVPHGEPGEL 407
Cdd:cd05920  263 GGARLSPALARRVPPVLGCTLQQVFGMAE--GLLNYtrldDPDEVIIHTQ--GRPMsPDDEIRVVDEEGNPVPPGEEGEL 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 408 CVRGPQVMLGYWQRPDA-TDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAV 486
Cdd:cd05920  339 LTRGPYTIRGYYRAPEHnARAFTPDGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVV 418
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489956626 487 GVPSGSSGEAVKIFVVKKDPSLTEDALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05920  419 AMPDELLGERSCAFVVLRDPPPSAAQLRRFLReRGLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482
PRK04319 PRK04319
acetyl-CoA synthetase; Provisional
50-550 2.45e-56

acetyl-CoA synthetase; Provisional


Pssm-ID: 235279 [Multi-domain]  Cd Length: 570  Bit Score: 198.58  E-value: 2.45e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVvnvNPLYT---PRELEHQLNDSGAAaiV 126
Cdd:PRK04319  75 TYKELKELSNKFANVLKE-LGVEKGDRVFIFMPRIPELYFALLGALKNGAIV---GPLFEafmEEAVRDRLEDSEAK--V 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 127 IVSNFAHTLEKVVEKT-QVKHViltrmgdqlstakgtlvnFVVKYVKRLVPKYhlpdaISFRRALHAG---YRMQYVKPE 202
Cdd:PRK04319 149 LITTPALLERKPADDLpSLKHV------------------LLVGEDVEEGPGT-----LDFNALMEQAsdeFDIEWTDRE 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 203 ivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqVNATYGPLLHPGKELVITALP------LYHIFALTMNCLLFIELG 276
Cdd:PRK04319 206 ----DGAILHYTSGSTGKPKGVLHVHNAMLQHY--QTGKYVLDLHEDDVYWCTADPgwvtgtSYGIFAPWLNGATNVIDG 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 277 GQnvliTNPRDIPGLvkeLAKYP----FTAMTGVNTLFNAllNNKEFQQLDFSTLHLSAGGGMPVQ-QAVaeRW-VKLTG 350
Cdd:PRK04319 280 GR----FSPERWYRI---LEDYKvtvwYTAPTAIRMLMGA--GDDLVKKYDLSSLRHILSVGEPLNpEVV--RWgMKVFG 348
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 351 QYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRG--PQVMLGYWQRPDATDEI 428
Cdd:PRK04319 349 LPIHDNWWMTETGGIMIANYPAMDIKPGSMGKPLPGIEAAIVDDQGNELPPNRMGNLAIKKgwPSMMRGIWNNPEKYESY 428
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 429 IKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD--- 505
Cdd:PRK04319 429 FAGDWYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAVAEAGVIGKPDPVRGEIIKAFVALRPgye 508
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 489956626 506 PS--LTEDaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK04319 509 PSeeLKEE-IRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRRVLK 554
LC_FACS_like cd17640
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...
50-561 2.53e-56

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341295 [Multi-domain]  Cd Length: 468  Bit Score: 196.04  E-value: 2.53e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGmiVVNVnplytPR-------ELEHQLNDSGA 122
Cdd:cd17640    7 TYKDLYQEILDFAAGLRS-LGVKAGEKVALFADNSPRWLIADQGIMALG--AVDV-----VRgsdssveELLYILNHSES 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 123 AAIVIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpE 202
Cdd:cd17640   79 VALVV--------------------------------------------------------------------------E 84
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 203 IVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllHPGKElVITALPLYHIFALTmnCLLFIELGGQNVLI 282
Cdd:cd17640   85 NDSDDLATIIYTSGTTGNPKGVMLTHANLLHQIRSLSDIVPP--QPGDR-FLSILPIWHSYERS--AEYFIFACGCSQAY 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 TNPRDIPglvKELAKYPFTAMTGVNTLFNALLNN--KE------FQQLDFSTL--------HLSAGGGMPVQqavAERWV 346
Cdd:cd17640  160 TSIRTLK---DDLKRVKPHYIVSVPRLWESLYSGiqKQvsksspIKQFLFLFFlsggifkfGISGGGALPPH---VDTFF 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 347 KLTGQYLLEGYGLTECAPLVSVNPHDIDYhSGSIGLPVPSTEAKLVDDEDNEV-PHGEPGELCVRGPQVMLGYWQRPDAT 425
Cdd:cd17640  234 EAIGIEVLNGYGLTETSPVVSARRLKCNV-RGSVGRPLPGTEIKIVDPEGNVVlPPGEKGIVWVRGPQVMKGYYKNPEAT 312
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 DEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQhSGVLEvaavgvpsgssgeavKIFVVK 503
Cdd:cd17640  313 SKVLdSDGWFNTGDLGWLTCGGELVLTGRAKDTIVLSnGENVEPQPIEEALMR-SPFIE---------------QIMVVG 376
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 504 KDPSlTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNKA 561
Cdd:cd17640  377 QDQK-RLGALIVPNFEELEKWAKESGVKLANDRSQLLASKKVLKLYKNEIKDEISNRP 433
AA-adenyl-dom TIGR01733
amino acid adenylation domain; This model represents a domain responsible for the specific ...
50-486 5.65e-56

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.


Pssm-ID: 273779 [Multi-domain]  Cd Length: 409  Bit Score: 193.64  E-value: 5.65e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   50 TFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:TIGR01733   1 TYRELDERANRLARHLRAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  130 NFAHTLEKVVEktqvkhVILTRMGDQLSTAKGTLVNFVvkyvkrlvpkyhlPDAISfrralhagyrmqyvkpeiVSEDLA 209
Cdd:TIGR01733  81 ALASRLAGLVL------PVILLDPLELAALDDAPAPPP-------------PDAPS------------------GPDDLA 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllhpGKELVITALPLYH-------IFAltmnCLLFielGGQNVLI 282
Cdd:TIGR01733 124 YVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGL----DPDDRVLQFASLSfdasveeIFG----ALLA---GATLVVP 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  283 TNP--RDIPGLVKEL-AKYPFTAMTGVNTLFNALLnnkEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQ-YLLEGYG 358
Cdd:TIGR01733 193 PEDeeRDDAALLAALiAEHPVTVLNLTPSLLALLA---AALPPALASLRLVILGGEALTPALVDRWRARGPGaRLINLYG 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  359 LTECAPLVSVNPHDIDYHSG----SIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKDG- 432
Cdd:TIGR01733 270 PTETTVWSTATLVDPDDAPRespvPIGRPLANTRLYVLDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAErFVPDPf 349
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626  433 -------WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVlEVAAV 486
Cdd:TIGR01733 350 aggdgarLYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGV-REAVV 409
BACL_like cd05929
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...
201-551 5.87e-56

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.


Pssm-ID: 341252 [Multi-domain]  Cd Length: 473  Bit Score: 195.29  E-value: 5.87e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 201 PEIVSEDLA---FLQYTGGTTGVAKGAMlthRNMLANLEQVNATYGPLL---HPGKELVITALPLYHI--FALTMNCLLf 272
Cdd:cd05929  117 PETPIEDEAagwKMLYSGGTTGRPKGIK---RGLPGGPPDNDTLMAAALgfgPGADSVYLSPAPLYHAapFRWSMTALF- 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 273 ieLGGQNVLITN--PRDIPGLVKelaKYPFTAMTGVNTLFNALLNNKEFQQ--LDFSTL----HlsAGGGMPVQqaVAER 344
Cdd:cd05929  193 --MGGTLVLMEKfdPEEFLRLIE---RYRVTFAQFVPTMFVRLLKLPEAVRnaYDLSSLkrviH--AAAPCPPW--VKEQ 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStEAKLVDDEDNEVPHGEPGELCVRGPQVMLgYWQRPDA 424
Cdd:cd05929  264 WIDWGGPIIWEYYGGTEGQGLTIINGEEWLTHPGSVGRAVLG-KVHILDEDGNEVPPGEIGEVYFANGPGFE-YTNDPEK 341
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 425 TDE-IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIfVVK 503
Cdd:cd05929  342 TAAaRNEGGWSTLGDVGYLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHA-VVQ 420
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489956626 504 KDPS-----LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05929  421 PAPGadagtALAEELIAFLRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLLRD 473
A_NRPS_Srf_like cd12117
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...
27-549 9.32e-56

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.


Pssm-ID: 341282 [Multi-domain]  Cd Length: 483  Bit Score: 195.11  E-value: 9.32e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd12117    1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRA-AGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAAIVIvsnfAHTLEKVVEKTQVKHVILtrmgDQLSTAkgtlvnfvvkyvkrlvpkyhlpDAISF 186
Cdd:cd12117   80 ELPAERLAFMLADAGAKVLLT----DRSLAGRAGGLEVAVVID----EALDAG----------------------PAGNP 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 RRALHAgyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvNATYGPLlhPGKELVITALPL------Y 260
Cdd:cd12117  130 AVPVSP-------------DDLAYVMYTSGSTGRPKGVAVTHRGVVRLVK--NTNYVTL--GPDDRVLQTSPLafdastF 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 261 HIFAltmnCLLFielGGQNVLIT--NPRDIPGLVKELAKYPFTAMTGVNTLFNALLnnkefqQLD---FSTL-HLSAGG- 333
Cdd:cd12117  193 EIWG----ALLN---GARLVLAPkgTLLDPDALGALIAEEGVTVLWLTAALFNQLA------DEDpecFAGLrELLTGGe 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 334 GMPVQQ--AVAERWVKLTgqyLLEGYGLTE---CAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELC 408
Cdd:cd12117  260 VVSPPHvrRVLAACPGLR---LVNGYGPTEnttFTTSHVVTELDEVAGSIPIGRPIANTRVYVLDEDGRPVPPGVPGELY 336
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 409 VRGPQVMLGYWQRPDATDE-IIKDGWL------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVL 481
Cdd:cd12117  337 VGGDGLALGYLNRPALTAErFVADPFGpgerlyRTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALRAHPGVR 416
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 482 EVAAVGVPSGSSGEAVKIFVVkKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12117  417 EAVVVVREDAGGDKRLVAYVV-AEGALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
PtmA cd17636
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...
213-538 1.60e-55

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341291 [Multi-domain]  Cd Length: 331  Bit Score: 190.21  E-value: 1.60e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 213 YTGGTTGVAKGAMLTHRN------MLANLEQVNATYGPLlhpgkelviTALPLYHIFALtMNCLLFIELGGQNVLI--TN 284
Cdd:cd17636    7 YTAAFSGRPNGALLSHQAllaqalVLAVLQAIDEGTVFL---------NSGPLFHIGTL-MFTLATFHAGGTNVFVrrVD 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 285 PRDIPGLV-KELAKYPFTAMTGVNTLFNAllnNKEFQqLDFSTLHlsAGGGMPVQQAVAERWVKLTGQYLlEGYGLTECA 363
Cdd:cd17636   77 AEEVLELIeAERCTHAFLLPPTIDQIVEL---NADGL-YDLSSLR--SSPAAPEWNDMATVDTSPWGRKP-GGYGQTEVM 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 364 PLVSVNPHDIDYHSGSiGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMD 443
Cdd:cd17636  150 GLATFAALGGGAIGGA-GRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTRGGWHHTNDLGRRE 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVK-IFVVKKDPSLTEDALITFCRRQLT 522
Cdd:cd17636  229 PDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKaIVVLKPGASVTEAELIEHCRARIA 308
                        330
                 ....*....|....*.
gi 489956626 523 GYKVPKLVEFRDELPK 538
Cdd:cd17636  309 SYKKPKSVEFADALPR 324
PRK06164 PRK06164
acyl-CoA synthetase; Validated
14-558 6.51e-55

acyl-CoA synthetase; Validated


Pssm-ID: 235722 [Multi-domain]  Cd Length: 540  Bit Score: 194.19  E-value: 6.51e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  14 PAEINPDRYQSLIElfEHsVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK06164   4 DAAPRADTLASLLD--AH-ARARPDAVALIDEDRPLSRAELRALVDRLAAWLAA-QGVRRGDRVAVWLPNCIEWVVLFLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  94 ILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFaHTLEKVVEKTQVKHviltrmgDQLSTAKGTLVnfvvkyVKR 173
Cdd:PRK06164  80 CARLGATVIAVNTRYRSHEVAHILGRGRARWLVVWPGF-KGIDFAAILAAVPP-------DALPPLRAIAV------VDD 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 174 LVPKyhLPDAISFRR----ALHAGYRMQYVKPEIVSEDLAFLQYT-GGTTGVAKGAMLTHRNMLANLEQVNATYGplLHP 248
Cdd:PRK06164 146 AADA--TPAPAPGARvqlfALPDPAPPAAAGERAADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAYG--YDP 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 249 GkELVITALPLYHIFALTMncLLFIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNnKEFQQLDFSTLH 328
Cdd:PRK06164 222 G-AVLLAALPFCGVFGFST--LLGALAGGAPLVCEPVFDAARTARALRRHRVTHTFGNDEMLRRILD-TAGERADFPSAR 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 LS-----AGGGMPVQQAVAERWVKLTGQYllegyGLTECAPLVSVNPHDIDY---HSGSiGLPV-PSTEAKLVDDEDNEV 399
Cdd:PRK06164 298 LFgfasfAPALGELAALARARGVPLTGLY-----GSSEVQALVALQPATDPVsvrIEGG-GRPAsPEARVRARDPQDGAL 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 400 -PHGEPGELCVRGPQVMLGYWQRPDAT-DEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQH 477
Cdd:PRK06164 372 lPDGESGEIEIRAPSLMRGYLDNPDATaRALTDDGYFRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEAL 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 478 SGVLEVAAVGVPSGSSGEAVKiFVVKKD-PSLTEDALITFCRRQLTGYKVPKLVEFRDELP---KSNVGKILRRELRDEA 553
Cdd:PRK06164 452 PGVAAAQVVGATRDGKTVPVA-FVIPTDgASPDEAGLMAACREALAGFKVPARVQVVEAFPvteSANGAKIQKHRLREMA 530

                 ....*
gi 489956626 554 RAKVD 558
Cdd:PRK06164 531 QARLA 535
PRK13382 PRK13382
bile acid CoA ligase;
11-551 7.31e-55

bile acid CoA ligase;


Pssm-ID: 172019 [Multi-domain]  Cd Length: 537  Bit Score: 193.82  E-value: 7.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  11 ADVPAEINPDRY-----------QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVAL 79
Cdd:PRK13382  20 AGLIAPMRPDRYlrivaamrregMGPTSGFAIAAQRCPDRPGLIDELGTLTWRELDERSDALAAALQ-ALPIGEPRVVGI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  80 MMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKhvilTRMGDQLSTA 159
Cdd:PRK13382  99 MCRNHRGFVEALLAANRIGADILLLNTSFAGPALAEVVTREGVDTVIYDEEFSATVDRALADCPQA----TRIVAWTDED 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 160 KGTLVNFVVkyvkrlvpkyhlpdaisfrrALHAGYRMQyvkPEIVSEDLAFLqyTGGTTGVAKGAMlthrnmlanlEQVN 239
Cdd:PRK13382 175 HDLTVEVLI--------------------AAHAGQRPE---PTGRKGRVILL--TSGTTGTPKGAR----------RSGP 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 240 ATYGPL--------LHPGKELVITAlPLYH-------IFALTMNCllfielggqnVLITNPR-DIPGLVKELAKYPFTAM 303
Cdd:PRK13382 220 GGIGTLkaildrtpWRAEEPTVIVA-PMFHawgfsqlVLAASLAC----------TIVTRRRfDPEATLDLIDRHRATGL 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 304 TGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIG 381
Cdd:PRK13382 289 AVVPVMFDRIMDlpAEVRNRYSGRSLRFAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPDTAG 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 382 LPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYwqRPDATDEIIkDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:PRK13382 369 RPAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGY--TSGSTKDFH-DGFMASGDVGYLDENGRLFVVGRDDEMIVSG 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 462 GFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSN 540
Cdd:PRK13382 446 GENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFVVlKPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGA 525
                        570
                 ....*....|.
gi 489956626 541 VGKILRRELRD 551
Cdd:PRK13382 526 TGKILRRELQA 536
DltA cd05945
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...
33-549 8.02e-54

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341267 [Multi-domain]  Cd Length: 449  Bit Score: 189.00  E-value: 8.02e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  33 VRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRE 112
Cdd:cd05945    1 AAANPDRPAVVEGGRTLTYRELKERADALAAALAS-LGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAER 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 113 LEHQLNDSGAAAIVIVsnfahtlekvvektqvkhviltrmGDqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralha 192
Cdd:cd05945   80 IREILDAAKPALLIAD------------------------GD-------------------------------------- 97
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 193 gyrmqyvkpeivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNAtYGPLlhpGKELVITALPLYHiFAL-TMNclL 271
Cdd:cd05945   98 --------------DNAYIIFTSGSTGRPKGVQISHDNLVSFTNWMLS-DFPL---GPGDVFLNQAPFS-FDLsVMD--L 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 272 FIELGGQNVLITNPRDIPG----LVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLS--AGGGMPVQQAvaERW 345
Cdd:cd05945  157 YPALASGATLVPVPRDATAdpkqLFRFLAEHGITVWVSTPSFAAMCLLSPTFTPESLPSLRHFlfCGEVLPHKTA--RAL 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VKLT-GQYLLEGYGLTECAPLVS---VNPHDID-YHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQ 420
Cdd:cd05945  235 QQRFpDARIYNTYGPTEATVAVTyieVTPEVLDgYDRLPIGYAKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLN 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 421 RPDATDE----IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEA 496
Cdd:cd05945  315 NPEKTAAaffpDEGQRAYRTGDLVRLEADGLLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYKGEKVTE 394
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489956626 497 VKIFVVKKDPSLTED--ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05945  395 LIAFVVPKPGAEAGLtkAIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
PRK13390 PRK13390
acyl-CoA synthetase; Provisional
38-550 3.90e-53

acyl-CoA synthetase; Provisional


Pssm-ID: 139538 [Multi-domain]  Cd Length: 501  Bit Score: 188.29  E-value: 3.90e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFV--NMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK13390  12 DRPAVIvaETGEQVSYRQLDDDSAALARVLYDA-GLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAPEADY 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 116 QLNDSGAAAIVIVSnfahTLEKVVEKTQVKHVILTRMGdqlstakGTLVNFVvkyvkrlvpkyhlpdaiSFRRALHAGyr 195
Cdd:PRK13390  91 IVGDSGARVLVASA----ALDGLAAKVGADLPLRLSFG-------GEIDGFG-----------------SFEAALAGA-- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 196 mqyvKPEIVSEDL-AFLQYTGGTTGVAKGAM--LTHRNMLANLEQVNATYGPLLH-PGKELVITALPLYHIFALTMnCLL 271
Cdd:PRK13390 141 ----GPRLTEQPCgAVMLYSSGTTGFPKGIQpdLPGRDVDAPGDPIVAIARAFYDiSESDIYYSSAPIYHAAPLRW-CSM 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 272 FIELGGqNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALL--NNKEFQQLDFSTL----HLSAGGGMPVQQAVAErW 345
Cdd:PRK13390 216 VHALGG-TVVLAKRFDAQATLGHVERYRITVTQMVPTMFVRLLklDADVRTRYDVSSLraviHAAAPCPVDVKHAMID-W 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VkltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTeAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDAT 425
Cdd:PRK13390 294 L---GPIVYEYYSSTEAHGMTFIDSPDWLAHPGSVGRSVLGD-LHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKT 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 DEIIKDG---WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV- 501
Cdd:PRK13390 370 AAAQHPAhpfWTTVGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIq 449
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489956626 502 ----VKKDPSLTEDaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK13390 450 lvegIRGSDELARE-LIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
A_NRPS_TubE_like cd05906
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...
14-551 1.10e-51

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341232 [Multi-domain]  Cd Length: 540  Bit Score: 185.18  E-value: 1.10e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  14 PAEINPDRYQSLIELFEHSVRRYADQ-PAFVNM---GEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPV 89
Cdd:cd05906    1 PLHRPEGAPRTLLELLLRAAERGPTKgITYIDAdgsEEFQSYQDLLEDARRLAAGLRQ-LGLRPGDSVILQFDDNEDFIP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  90 ALFGILRAGMIVVNVNPLYTPRELEHQLNDsgaaaiviVSNFAHTLEKVVektqvkhvILT--RMGDQLSTAKGTLVnfv 167
Cdd:cd05906   80 AFWACVLAGFVPAPLTVPPTYDEPNARLRK--------LRHIWQLLGSPV--------VLTdaELVAEFAGLETLSG--- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 168 vkyvkrlvpkyHLPDAISFRRALHAGYRmQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpllH 247
Cdd:cd05906  141 -----------LPGIRVLSIEELLDTAA-DHDLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNG---L 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 248 PGKELVITALPLYHIFALTMNCLLFIELGGQNV------LITNPRDIPGLVKelaKYPFTAMTGVNTLFnALLNNK---- 317
Cdd:cd05906  206 TPQDVFLNWVPLDHVGGLVELHLRAVYLGCQQVhvpteeILADPLRWLDLID---RYRVTITWAPNFAF-ALLNDLleei 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 318 EFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLE------GYGLTE-CAPLV-----SVNPHDIDYHSGSIGLPVP 385
Cdd:cd05906  282 EDGTWDLSSLRYLVNAGEAVVAKTIRRLLRLLEPYGLPpdairpAFGMTEtCSGVIysrsfPTYDHSQALEFVSLGRPIP 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 386 STEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDeGFLRIVDRKKDMILVSGFN 464
Cdd:cd05906  362 GVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEAFtEDGWFRTGDLGFLDN-GNLTITGRTKDTIIVNGVN 440
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 465 VYPNEIEDVVMQHSGVLE--VAAVGV--PSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLT---GYKVPKLVEF-RDEL 536
Cdd:cd05906  441 YYSHEIEAAVEEVPGVEPsfTAAFAVrdPGAETEELAIFFVPEYDLQDALSETLRAIRSVVSrevGVSPAYLIPLpKEEI 520
                        570
                 ....*....|....*
gi 489956626 537 PKSNVGKILRRELRD 551
Cdd:cd05906  521 PKTSLGKIQRSKLKA 535
EntF COG1020
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...
4-555 1.41e-51

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440643 [Multi-domain]  Cd Length: 1329  Bit Score: 190.84  E-value: 1.41e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626    4 VWLNRYPADVPAEinpdryQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPN 83
Cdd:COG1020   463 AEWNATAAPYPAD------ATLHELFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRA-LGVGPGDLVGVCLER 535
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   84 LLQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSNFAHTLEKvvekTQVKHVILtrmgDQLSTAkgt 162
Cdd:COG1020   536 SLEMVVALLAVLKAGAAYVPLDPAY-PAErLAYMLEDAGARLVLTQSALAARLPE----LGVPVLAL----DALALA--- 603
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  163 lvnfvvkyvkrlvpkyHLPDAisfrralhagyrmqYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATY 242
Cdd:COG1020   604 ----------------AEPAT--------------NPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWMQRRY 653
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  243 GplLHPG-KELVITAL----PLYHIFAltmnCLLFielGGQNVLITN--PRDIPGLVKELAKYPFTAMTGVNTLFNALLn 315
Cdd:COG1020   654 G--LGPGdRVLQFASLsfdaSVWEIFG----ALLS---GATLVLAPPeaRRDPAALAELLARHRVTVLNLTPSLLRALL- 723
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  316 nkEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQY-LLEGYGLTECAPLVS---VNPHDIDYHSGSIGLPVPSTEAKL 391
Cdd:COG1020   724 --DAAPEALPSLRLVLVGGEALPPELVRRWRARLPGArLVNLYGPTETTVDSTyyeVTPPDADGGSVPIGRPIANTRVYV 801
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  392 VDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDE------IIKDG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGF 463
Cdd:COG1020   802 LDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAErfvadpFGFPGarLYRTGDLARWLPDGNLEFLGRADDQVKIRGF 881
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  464 NVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALITFC-RRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:COG1020   882 RIELGEIEAALLQHPGVREAVVVAREDAPGDKRLVAYVVPEAGAAAAAALLRLAlALLLPPYMVPAAVVLLLPLPLTGNG 961
                         570
                  ....*....|...
gi 489956626  543 KILRRELRDEARA 555
Cdd:COG1020   962 KLDRLALPAPAAA 974
OSB_MenE-like cd17630
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...
207-551 5.85e-51

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.


Pssm-ID: 341285 [Multi-domain]  Cd Length: 325  Bit Score: 177.91  E-value: 5.85e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNAtygpLLHPGKELV-ITALPLYHI--FALTMNCLLfieLGGQNVLIT 283
Cdd:cd17630    1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHS----RLGFGGGDSwLLSLPLYHVggLAILVRSLL---AGAELVLLE 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 284 NPRDipgLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmPVQQAVAERWVKLtGQYLLEGYGLTECA 363
Cdd:cd17630   74 RNQA---LAEDLAPPGVTHVSLVPTQLQRLLDSGQGPAALKSLRAVLLGGA-PIPPELLERAADR-GIPLYTTYGMTETA 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 364 PLVSVNPHDiDYHSGSIGLPVPSTEAKLVDDednevphgepGELCVRGPQVMLGYWqRPDATDEIIKDGWLHTGDIAVMD 443
Cdd:cd17630  149 SQVATKRPD-GFGRGGVGVLLPGRELRIVED----------GEIWVGGASLAMGYL-RGQLVPEFNEDGWFTTKDLGELH 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVkIFVVKKDPSLTEDALITFCRRQLTG 523
Cdd:cd17630  217 ADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRP-VAVIVGRGPADPAELRAWLKDKLAR 295
                        330       340
                 ....*....|....*....|....*...
gi 489956626 524 YKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd17630  296 FKLPKRIYPVPELPRTGGGKVDRRALRA 323
A_NRPS_Ta1_like cd12116
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...
38-549 1.12e-47

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.


Pssm-ID: 341281 [Multi-domain]  Cd Length: 470  Bit Score: 172.86  E-value: 1.12e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQ 116
Cdd:cd12116    2 DATAVRDDDRSLSYAELDERANRLAARLR-ARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDY-PADrLRYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 117 LNDSGAAAIVIVSNFAHTLekvvektqvkHVILTRMGDQLSTAKGTLVNfvvkyvkrlvpkyhlpdaisfrralhagyrm 196
Cdd:cd12116   80 LEDAEPALVLTDDALPDRL----------PAGLPVLLLALAAAAAAPAA------------------------------- 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 197 qyVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITALPLYHIFALTMncLLFIELG 276
Cdd:cd12116  119 --PRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLG--LGPGDRLLAVTTYAFDISLLEL--LLPLLAG 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 277 GQNVLI--TNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNkEFQQLDfsTLHLSAGGgMPVQQAVAERWVKLTGQyLL 354
Cdd:cd12116  193 ARVVIAprETQRDPEALARLIEAHSITVMQATPATWRMLLDA-GWQGRA--GLTALCGG-EALPPDLAARLLSRVGS-LW 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 355 EGYGLTE-----CAPLVSVNPHDIDyhsgsIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEII 429
Cdd:cd12116  268 NLYGPTEttiwsTAARVTAAAGPIP-----IGRPLANTQVYVLDAALRPVPPGVPGELYIGGDGVAQGYLGRPALTAERF 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 430 KDG--------WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV 501
Cdd:cd12116  343 VPDpfagpgsrLYRTGDLVRRRADGRLEYLGRADGQVKIRGHRIELGEIEAALAAHPGVAQAAVVVREDGGDRRLVAYVV 422
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 489956626 502 VKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12116  423 LKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKLDRKAL 470
AACS_like cd05968
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...
27-550 1.15e-47

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.


Pssm-ID: 341272 [Multi-domain]  Cd Length: 610  Bit Score: 175.37  E-value: 1.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:cd05968   65 QLLDKWLADTRTRPALRWEGEdgtsrTLTYGELLYEVKRLANGLRA-LGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIV 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAH---------TLEKVVEKT-QVKHVILTRMGDQLSTAkgTLVNFVvkyv 171
Cdd:cd05968  144 VPIFSGFGKEAAATRLQDAEAKALITADGFTRrgrevnlkeEADKACAQCpTVEKVVVVRHLGNDFTP--AKGRDL---- 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 172 krlvpKYHLPDAISFRRALHAGyrmqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMlanleqvnatygpllhPGKe 251
Cdd:cd05968  218 -----SYDEEKETAGDGAERTE-----------SEDPLMIIYTSGTTGKPKGTVHVHAGF----------------PLK- 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 252 lviTALPLYHIFALTMNCLLF-----------------IELGGQNVLITNPRDIPG---LVKELAKYPFTAMTGVNTLFN 311
Cdd:cd05968  265 ---AAQDMYFQFDLKPGDLLTwftdlgwmmgpwlifggLILGATMVLYDGAPDHPKadrLWRMVEDHEITHLGLSPTLIR 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 312 ALLNNKE--FQQLDFSTLHLSAGGGMPVQqavAERWvkltgQYLLEGYGLTECaPLvsvnphdIDYHSG----------- 378
Cdd:cd05968  342 ALKPRGDapVNAHDLSSLRVLGSTGEPWN---PEPW-----NWLFETVGKGRN-PI-------INYSGGteisggilgnv 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 379 --------SIGLPVPSTEAKLVDDEDNEVPhGEPGELCVRGPQVML--GYWQRPDATDEI----IKDGWLHtGDIAVMDD 444
Cdd:cd05968  406 likpikpsSFNGPVPGMKADVLDESGKPAR-PEVGELVLLAPWPGMtrGFWRDEDRYLETywsrFDNVWVH-GDFAYYDE 483
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD----PSLTEDALITFCRRQ 520
Cdd:cd05968  484 EGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHPVKGEAIVCFVVLKPgvtpTEALAEELMERVADE 563
                        570       580       590
                 ....*....|....*....|....*....|
gi 489956626 521 LTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05968  564 LGKPLSPERILFVKDLPKTRNAKVMRRVIR 593
PRK05852 PRK05852
fatty acid--CoA ligase family protein;
24-547 3.91e-47

fatty acid--CoA ligase family protein;


Pssm-ID: 235625 [Multi-domain]  Cd Length: 534  Bit Score: 172.76  E-value: 3.91e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  24 SLIELFEHSVRRYADQPAFVNMGE--VMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK05852  17 RIADLVEVAATRLPEAPALVVTADriAISYRDLARLVDDLAGQLTRS-GLLPGDRVALRMGSNAEFVVALLAASRADLVV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHtleKVVEKTQVKHVILTRMGDQLSTAKGTLvnfvvkyvkrlvpKYHLP 181
Cdd:PRK05852  96 VPLDPALPIAEQRVRSQAAGARVVLIDADGPH---DRAEPTTRWWPLTVNVGGDSGPSGGTL-------------SVHLD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 182 DAISFRRALHAgyrmqyvkPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITaLPLYH 261
Cdd:PRK05852 160 AATEPTPATST--------PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYR--LSPRDATVAV-MPLYH 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 262 IFALtMNCLLFIELGGQNVLItnprdiPGLVK--------ELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSA 331
Cdd:PRK05852 229 GHGL-IAALLATLASGGAVLL------PARGRfsahtfwdDIKAVGATWYTAVPTIHQILLEraATEPSGRKPAALRFIR 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 332 GGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS----GSIGLPVPSTEA--KLVDDEDNEVPHGEPG 405
Cdd:PRK05852 302 SCSAPLTAETAQALQTEFAAPVVCAFGMTEATHQVTTTQIEGIGQTenpvVSTGLVGRSTGAqiRIVGSDGLPLPAGAVG 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 406 ELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAA 485
Cdd:PRK05852 382 EVWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAV 461
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489956626 486 VGVPSGSSGEAVKIFVVKKDPS-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK05852 462 FGVPDQLYGEAVAAVIVPRESApPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRR 524
A_NRPS_GliP_like cd17653
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...
27-551 4.07e-47

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341308 [Multi-domain]  Cd Length: 433  Bit Score: 170.18  E-value: 4.07e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17653    1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQ-LGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAAIVivsnfahtlekvvektqvkhviltrmgdqlSTAKGtlvnfvvkyvkrlvpkyhlpdaisf 186
Cdd:cd17653   80 KLPSARIQAILRTSGATLLL------------------------------TTDSP------------------------- 104
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 rralhagyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITALPLYHIFALT 266
Cdd:cd17653  105 -------------------DDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARLD--VGPGSRVAQVLSIAFDACIGE 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 267 M-NCLLFielGGQNVLITNPRDIPGLVKELAKYPFTAMtgvntlFNALLNNKEFQQLDFSTLhlsagGGMPVQQAVAERW 345
Cdd:cd17653  164 IfSTLCN---GGTLVLADPSDPFAHVARTVDALMSTPS------ILSTLSPQDFPNLKTIFL-----GGEAVPPSLLDRW 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VKltGQYLLEGYGLTECApLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDAT 425
Cdd:cd17653  230 SP--GRRLYNAYGPTECT-ISSTMTELLPGQPVTIGKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARGYLGNPALT 306
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 DEIIK-----DGWLH--TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVpsgsSGEAVK 498
Cdd:cd17653  307 ASKFVpdpfwPGSRMyrTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEIEEVVLQSQPEVTQAAAIV----VNGRLV 382
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489956626 499 IFVVKKdpSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd17653  383 AFVTPE--TVDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALRE 433
A_NRPS_AB3403-like cd17646
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...
27-549 7.24e-47

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341301 [Multi-domain]  Cd Length: 488  Bit Score: 170.92  E-value: 7.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17646    2 ALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRA-RGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDqlstakgtlvnfvvkyvkrlvpkyHLPDaisf 186
Cdd:cd17646   81 GYPADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGDEALAAPPA------------------------TPPL---- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 rralhagyrmqyvkPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYgPLLHPGKELVITALPlyhiFALT 266
Cdd:cd17646  133 --------------VPPRPDNLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEY-PLGPGDRVLQKTPLS----FDVS 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 267 MNCLLFIELGGQNVLITNP---RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDfsTLHLSAGGGMPVQQAVAE 343
Cdd:cd17646  194 VWELFWPLVAGARLVVARPgghRDPAYLAALIREHGVTTCHFVPSMLRVFLAEPAAGSCA--SLRRVFCSGEALPPELAA 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 344 RWVKLTGQYLLEGYGLTECAplVSVNPH----DIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYW 419
Cdd:cd17646  272 RFLALPGAELHNLYGPTEAA--IDVTHWpvrgPAETPSVPIGRPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGYL 349
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDATDEIIKDGWL-------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGS 492
Cdd:cd17646  350 GRPALTAERFVPDPFgpgsrmyRTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAPA 429
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 493 SGEAVKIFVVKKD--PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17646  430 GAARLVGYVVPAAgaAGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488
LC-FACS_euk cd05927
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...
49-476 2.21e-46

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.


Pssm-ID: 341250 [Multi-domain]  Cd Length: 545  Bit Score: 170.86  E-value: 2.21e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFA-AYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLY---TPRELEHQLNDSGAAA 124
Cdd:cd05927    6 ISYKEVAERADNIGsALRSLGGKPAPASFVGIYSINRPEWIISELACYAYSLVTV---PLYdtlGPEAIEYILNHAEISI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 125 IVIVSNFAHTLEKVVEKtqvkhviltrMGDqlstakgtlvnfvvKYVKRLVPKyhlpdaisfrralhagyrmqyvKPEiv 204
Cdd:cd05927   83 VFCDAGVKVYSLEEFEK----------LGK--------------KNKVPPPPP----------------------KPE-- 114
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 seDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELV-ITALPLYHIF-ALTMNCLLFIelGGQnvlI 282
Cdd:cd05927  115 --DLATICYTSGTTGNPKGVMLTHGNIVSNVAGVFKILEILNKINPTDVyISYLPLAHIFeRVVEALFLYH--GAK---I 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 TNPR-DIPGLVKELAKYPFTAMTGV----------------------NTLFNALLNNKE-------------FQQLDFST 326
Cdd:cd05927  188 GFYSgDIRLLLDDIKALKPTVFPGVprvlnriydkifnkvqakgplkRKLFNFALNYKLaelrsgvvraspfWDKLVFNK 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 327 LHLSAG--------GGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLVD----- 393
Cdd:cd05927  268 IKQALGgnvrlmltGSAPLSPEVLEFLRVALGCPVLEGYGQTECTAGATLTLPG-DTSVGHVGGPLPCAEVKLVDvpemn 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 394 -DEDNEVPHGEpgeLCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMI-LVSGFNVYPNEI 470
Cdd:cd05927  347 yDAKDPNPRGE---VCIRGPNVFSGYYKDPEKTAEALdEDGWLHTGDIGEWLPNGTLKIIDRKKNIFkLSQGEYVAPEKI 423

                 ....*.
gi 489956626 471 EDVVMQ 476
Cdd:cd05927  424 ENIYAR 429
MACS_like_2 cd05973
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
49-550 1.44e-45

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341277 [Multi-domain]  Cd Length: 437  Bit Score: 166.15  E-value: 1.44e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAaai 125
Cdd:cd05973    1 LTFGELRALSARFANALQE-LGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQ---PLFTafgPKAIEHRLRTSGA--- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 vivsnfahtlekvvektqvkHVILTRMgDQLSTakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeiVS 205
Cdd:cd05973   74 --------------------RLVVTDA-ANRHK---------------------------------------------LD 87
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLAnlEQVNATYGPLLHPGKELVITALP--LYHIFALTMNCLLfieLGGQNVLIT 283
Cdd:cd05973   88 SDPFVMMFTSGTTGLPKGVPVPLRALAA--FGAYLRDAVDLRPEDSFWNAADPgwAYGLYYAITGPLA---LGHPTILLE 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 284 NPRDIPGLVKELAKYPFTAMTGVNTLFNALL-NNKEFQQLDFSTLHLSAGGGMPVQQAVAeRWVKLT-GQYLLEGYGLTE 361
Cdd:cd05973  163 GGFSVESTWRVIERLGVTNLAGSPTAYRLLMaAGAEVPARPKGRLRRVSSAGEPLTPEVI-RWFDAAlGVPIHDHYGQTE 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 362 CApLVSVNPHDIDY--HSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCV---RGPQVML-GYWQRPDATdeiIKDGWLH 435
Cdd:cd05973  242 LG-MVLANHHALEHpvHAGSAGRAMPGWRVAVLDDDGDELGPGEPGRLAIdiaNSPLMWFrGYQLPDTPA---IDGGYYL 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 436 TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-----KKDPSLtE 510
Cdd:cd05973  318 TGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVlrgghEGTPAL-A 396
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|
gi 489956626 511 DALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05973  397 DELQLHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLR 436
PRK07008 PRK07008
long-chain-fatty-acid--CoA ligase; Validated
28-554 5.07e-44

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235908 [Multi-domain]  Cd Length: 539  Bit Score: 164.11  E-value: 5.07e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  28 LFEHSVRRYADqpafvnmGEVM-----------TFRKLEERSRAFAAYLqEGLGLQKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK07008  15 LIAHAARHAGD-------TEIVsrrvegdihryTYRDCERRAKQLAQAL-AALGVEPGDRVGTLAWNGYRHLEAYYGVSG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEK-TQVKHVILtrMGDqlstakgtlvnfvvkyvkrlv 175
Cdd:PRK07008  87 SGAVCHTINPRLFPEQIAYIVNHAEDRYVLFDLTFLPLVDALAPQcPNVKGWVA--MTD--------------------- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 176 pKYHLP-DAISFR--RALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNmlanleQVNATYGPLLhP---- 248
Cdd:PRK07008 144 -AAHLPaGSTPLLcyETLVGAQDGDYDWPRFDENQASSLCYTSGTTGNPKGALYSHRS------TVLHAYGAAL-Pdamg 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 249 --GKELVITALPLYHIFA--LTMNCLLfieLGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF 324
Cdd:PRK07008 216 lsARDAVLPVVPMFHVNAwgLPYSAPL---TGAKLVLPGPDLDGKSLYELIEAERVTFSAGVPTVWLGLLNHMREAGLRF 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 325 STLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSV----NPHDIDYHSGSI------GLPVPSTEAKLVDD 394
Cdd:PRK07008 293 STLRRTVIGGSACPPAMIRTFEDEYGVEVIHAWGMTEMSPLGTLcklkWKHSQLPLDEQRkllekqGRVIYGVDMKIVGD 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 395 EDNEVPH-GEP-GELCVRGPQVMLGYWQRpdaTDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIED 472
Cdd:PRK07008 373 DGRELPWdGKAfGDLQVRGPWVIDRYFRG---DASPLVDGWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIEN 449
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 473 VVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKK-DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK07008 450 VAVAHPAVAEAACIACAHPKWDERPLLVVVKRpGAEVTREELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLRE 529

                 ...
gi 489956626 552 EAR 554
Cdd:PRK07008 530 QFR 532
A_NRPS_VisG_like cd17651
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...
29-550 1.01e-43

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341306 [Multi-domain]  Cd Length: 491  Bit Score: 162.51  E-value: 1.01e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  29 FEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLqEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLY 108
Cdd:cd17651    1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRL-RARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 109 TPRELEHQLNDSGAAAIVIVSNFAHTLEkvvektqVKHVILTRMGDQLSTAKGTLvnfvvkyvkrlvpkyhlpdaiSFRR 188
Cdd:cd17651   80 PAERLAFMLADAGPVLVLTHPALAGELA-------VELVAVTLLDQPGAAAGADA---------------------EPDP 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 189 ALHAGyrmqyvkpeivseDLAFLQYTGGTTGVAKGAMLTHRnMLANLEQVNATYGPLlHPGKELVITALPLYHIFALTmn 268
Cdd:cd17651  132 ALDAD-------------DLAYVIYTSGSTGRPKGVVMPHR-SLANLVAWQARASSL-GPGARTLQFAGLGFDVSVQE-- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 269 clLFIEL--GGQNVLITNP--RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH--LSAGGGMPVQQAVA 342
Cdd:cd17651  195 --IFSTLcaGATLVLPPEEvrTDPPALAAWLDEQRISRVFLPTVALRALAEHGRPLGVRLAALRylLTGGEQLVLTEDLR 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 343 ERWVKLTGQYLLEGYGLTEcAPLVS--VNPHDIDYH--SGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGY 418
Cdd:cd17651  273 EFCAGLPGLRLHNHYGPTE-THVVTalSLPGDPAAWpaPPPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGY 351
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 419 WQRPDATDE-IIKDGWL------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSG 491
Cdd:cd17651  352 LNRPELTAErFVPDPFVpgarmyRTGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREDR 431
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 492 SSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd17651  432 PGEKRLVAYVVgDPEAPVDAAELRAALATHLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491
PLN02860 PLN02860
o-succinylbenzoate-CoA ligase
31-553 3.23e-43

o-succinylbenzoate-CoA ligase


Pssm-ID: 215464 [Multi-domain]  Cd Length: 563  Bit Score: 162.28  E-value: 3.23e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  31 HSVRRYADQPAFVNmgEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTP 110
Cdd:PLN02860  17 ATLRGNAVVTISGN--RRRTGHEFVDGVLSLAAGLLR-LGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSF 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 111 RELEHQLNDSGAAAIVIVSNFAHTLEKVvEKTQVKHVILTRMGDQLSTAKGT-LVNFV-VKYVKRLVPKYHLPDaisfrr 188
Cdd:PLN02860  94 EEAKSAMLLVRPVMLVTDETCSSWYEEL-QNDRLPSLMWQVFLESPSSSVFIfLNSFLtTEMLKQRALGTTELD------ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 189 alhagyrmqyvkPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNM----LANLEQVNatYGP---LLHpgkelviTAlPLYH 261
Cdd:PLN02860 167 ------------YAWAPDDAVLICFTSGTTGRPKGVTISHSALivqsLAKIAIVG--YGEddvYLH-------TA-PLCH 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 262 IFALTmNCLLFIELGGQNVLItnPR-DIPGLVKELAKYPFTAMTGVNTLFNALL-------NNKEFQQLdfsTLHLSAGG 333
Cdd:PLN02860 225 IGGLS-SALAMLMVGACHVLL--PKfDAKAALQAIKQHNVTSMITVPAMMADLIsltrksmTWKVFPSV---RKILNGGG 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 334 GMPVQqaVAERWVKL-TGQYLLEGYGLTE-CAPLVSVNPHDID---------------------YHSGSIGLPVPSTEAK 390
Cdd:PLN02860 299 SLSSR--LLPDAKKLfPNAKLFSAYGMTEaCSSLTFMTLHDPTlespkqtlqtvnqtksssvhqPQGVCVGKPAPHVELK 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 391 LVDDEDNEVphgepGELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PLN02860 377 IGLDESSRV-----GRILTRGPHVMLGYWGQNSETASVLsNDGWLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEE 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 470 IEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV---------------VKKDPSLTEDALITFCRRQ-LTGYKVPKL-VEF 532
Cdd:PLN02860 452 VEAVLSQHPGVASVVVVGVPDSRLTEMVVACVrlrdgwiwsdnekenAKKNLTLSSETLRHHCREKnLSRFKIPKLfVQW 531
                        570       580
                 ....*....|....*....|.
gi 489956626 533 RDELPKSNVGKILRRELRDEA 553
Cdd:PLN02860 532 RKPFPLTTTGKIRRDEVRREV 552
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
46-544 6.85e-43

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 164.75  E-value: 6.85e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   46 GEVMTFRKLEERSRAFAAYLQEGLGLqkGDRVALMMPNLLQYPVALFGILRAGMIVVNVNplYTprelehqlndSGAAAI 125
Cdd:PRK06814  656 NGPLTYRKLLTGAFVLGRKLKKNTPP--GENVGVMLPNANGAAVTFFALQSAGRVPAMIN--FS----------AGIANI 721
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  126 VIVSNFAhtlekvvektQVKHVILTR-------MGDqLSTAKGTLVNFVvkYVKRLVPKYHLPDAIsfrRALHAGYRMQY 198
Cdd:PRK06814  722 LSACKAA----------QVKTVLTSRafiekarLGP-LIEALEFGIRII--YLEDVRAQIGLADKI---KGLLAGRFPLV 785
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  199 VKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGkELVITALPLYHIFALTMNCLLFIELGGQ 278
Cdd:PRK06814  786 YFCNRDPDDPAVILFTSGSEGTPKGVVLSHRNLLANRAQVAARID--FSPE-DKVFNALPVFHSFGLTGGLVLPLLSGVK 862
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  279 NVLITNP---RDIPGLVKELAKypfTAMTGVNTLFNALLNNKefQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLE 355
Cdd:PRK06814  863 VFLYPSPlhyRIIPELIYDTNA---TILFGTDTFLNGYARYA--HPYDFRSLRYVFAGAEKVKEETRQTWMEKFGIRILE 937
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  356 GYGLTECAPLVSVN-P-HDidyHSGSIGLPVPSTEAKLVddednEVPhG--EPGELCVRGPQVMLGYWqRPDA--TDEII 429
Cdd:PRK06814  938 GYGVTETAPVIALNtPmHN---KAGTVGRLLPGIEYRLE-----PVP-GidEGGRLFVRGPNVMLGYL-RAENpgVLEPP 1007
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  430 KDGWLHTGDIAVMDDEGFLRIVDRKK-------DMILVSGFNVYPNEIeDVVMQHsgvlevAAVGVPSGSSGEavKIFVV 502
Cdd:PRK06814 1008 ADGWYDTGDIVTIDEEGFITIKGRAKrfakiagEMISLAAVEELAAEL-WPDALH------AAVSIPDARKGE--RIILL 1078
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 489956626  503 KKDPSLTEDALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKI 544
Cdd:PRK06814 1079 TTASDATRAAFLAHAKaAGASELMVPAEIITIDEIPLLGTGKI 1121
FADD10 cd17635
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...
206-546 2.13e-42

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.


Pssm-ID: 341290 [Multi-domain]  Cd Length: 340  Bit Score: 155.11  E-value: 2.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLE-----QVNATYGpllhpgkELVITALPLYHIFAL--TMNCLLFielGGQ 278
Cdd:cd17635    1 EDPLAVIFTSGTTGEPKAVLLANKTFFAVPDilqkeGLNWVVG-------DVTYLPLPATHIGGLwwILTCLIH---GGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 279 NVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLN-----NKEFQQLDFstlhLSAGGGMPVQQ--AVAErWVKLTGq 351
Cdd:cd17635   71 CVTGGENTTYKSLFKILTTNAVTTTCLVPTLLSKLVSelksaNATVPSLRL----IGYGGSRAIAAdvRFIE-ATGLTN- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 352 yLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKD 431
Cdd:cd17635  145 -TAQVYGLSETGTALCLPTDDDSIEINAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVLID 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 432 GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVK---KDPSL 508
Cdd:cd17635  224 GWVNTGDLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAVVAsaeLDENA 303
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 489956626 509 TEdALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17635  304 IR-ALKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
A_NRPS_Bac cd17655
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...
27-549 2.15e-42

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341310 [Multi-domain]  Cd Length: 490  Bit Score: 158.64  E-value: 2.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17655    1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREK-GVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAAIVIVSNFAHTLEkvvektQVKHVILTrmgDQLSTAKGTLVNFvvkyvkrlvpkyhlpdaisf 186
Cdd:cd17655   80 DYPEERIQYILEDSGADILLTQSHLQPPIA------FIGLIDLL---DEDTIYHEESENL-------------------- 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 rralhagyrmqyvKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYgpllHPGKELVITALPLYHiFALT 266
Cdd:cd17655  131 -------------EPVSKSDDLAYVIYTSGSTGKPKGVMIEHRGVVNLVEWANKVI----YQGEHLRVALFASIS-FDAS 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 267 MNCLLFIELGGqNVLITNPR----DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLhLSAGGGMPVQqaVA 342
Cdd:cd17655  193 VTEIFASLLSG-NTLYIVRKetvlDGQALTQYIRQNRITIIDLTPAHLKLLDAADDSEGLSLKHL-IVGGEALSTE--LA 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 343 ERWVKLTGQ--YLLEGYGLTE---CAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLG 417
Cdd:cd17655  269 KKIIELFGTnpTITNAYGPTEttvDASIYQYEPETDQQVSVPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARG 348
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 418 YWQRPDATDE-IIKDGWL------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEvAAVGVPS 490
Cdd:cd17655  349 YLNRPELTAEkFVDDPFVpgermyRTGDLARWLPDGNIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKE-AVVIARK 427
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 491 GSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17655  428 DEQGQNYLCAYIVSEKELPVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKAL 486
PLN02736 PLN02736
long-chain acyl-CoA synthetase
6-473 2.55e-42

long-chain acyl-CoA synthetase


Pssm-ID: 178337 [Multi-domain]  Cd Length: 651  Bit Score: 161.04  E-value: 2.55e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   6 LNRYPaDVPaEInpdryQSLIELFEHSVRRYADQPAFVN-------MGEV--MTFRKL-EERSRAFAAYLQegLGLQKGD 75
Cdd:PLN02736  34 VSRFP-DHP-EI-----GTLHDNFVYAVETFRDYKYLGTrirvdgtVGEYkwMTYGEAgTARTAIGSGLVQ--HGIPKGA 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  76 RVALMMPNLLQYPVALFGILRAGMIVVnvnPLYtprelehqlnDS-GAAAIVIVSNFAhtlekVVEKTQVKHVILTRMGD 154
Cdd:PLN02736 105 CVGLYFINRPEWLIVDHACSAYSYVSV---PLY----------DTlGPDAVKFIVNHA-----EVAAIFCVPQTLNTLLS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 155 QLSTAKGTLVNFVVKYVKRLVPKyhLPDA-----ISFRRALHAGYRMQ--YVKPEivSEDLAFLQYTGGTTGVAKGAMLT 227
Cdd:PLN02736 167 CLSEIPSVRLIVVVGGADEPLPS--LPSGtgveiVTYSKLLAQGRSSPqpFRPPK--PEDVATICYTSGTTGTPKGVVLT 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 228 HRNMLANLeqVNATYGPLLHPGkELVITALPLYHIFAlTMNCLLFIELG-------GQN-------------VLITNPR- 286
Cdd:PLN02736 243 HGNLIANV--AGSSLSTKFYPS-DVHISYLPLAHIYE-RVNQIVMLHYGvavgfyqGDNlklmddlaalrptIFCSVPRl 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 ------DIPGLVKE---LAKYPFTAmtGVNTLFNALLNNKE----FQQLDFSTLHLSAGGGM--------PVQQAVAERW 345
Cdd:PLN02736 319 ynriydGITNAVKEsggLKERLFNA--AYNAKKQALENGKNpspmWDRLVFNKIKAKLGGRVrfmssgasPLSPDVMEFL 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VKLTGQYLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTEAKLVD-------DEDNEVPHGEpgeLCVRGPQVMLGY 418
Cdd:PLN02736 397 RICFGGRVLEGYGMTETSCVIS-GMDEGDNLSGHVGSPNPACEVKLVDvpemnytSEDQPYPRGE---ICVRGPIIFKGY 472
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 419 WQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDV 473
Cdd:PLN02736 473 YKDEVQTREVIdEDGWLHTGDIGLWLPGGRLKIIDRKKNIFkLAQGEYIAPEKIENV 529
A_NRPS_Sfm_like cd12115
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...
27-549 2.58e-42

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.


Pssm-ID: 341280 [Multi-domain]  Cd Length: 447  Bit Score: 157.48  E-value: 2.58e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd12115    3 DLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLR-AAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAaivivsnfahtlekvvektqvkhVILTRmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisf 186
Cdd:cd12115   82 AYPPERLRFILEDAQAR-----------------------LVLTD----------------------------------- 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 rralhagyrmqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYgpllhPGKEL--VITA------LP 258
Cdd:cd12115  104 ------------------PDDLAYVIYTSGSTGRPKGVAIEHRNAAAFLQWAAAAF-----SAEELagVLAStsicfdLS 160
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 259 LYHIFAlTMNCllfielGGQNVLITNPRDIPGLVkelAKYPFTAMTGVNTLFNALLNNKEFQQlDFSTLHLsAGGGMPvQ 338
Cdd:cd12115  161 VFELFG-PLAT------GGKVVLADNVLALPDLP---AAAEVTLINTVPSAAAELLRHDALPA-SVRVVNL-AGEPLP-R 227
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 339 QAVAERWVKLTGQYLLEGYGLTEC---APLVSVNPHDIDyhSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVM 415
Cdd:cd12115  228 DLVQRLYARLQVERVVNLYGPSEDttySTVAPVPPGASG--EVSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVA 305
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 416 LGYWQRPDATDE-IIKDGWL------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGV 488
Cdd:cd12115  306 RGYLGRPGLTAErFLPDPFGpgarlyRTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAI 385
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489956626 489 PSGSSGEAVKIFVVKKDPS-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12115  386 GDAAGERRLVAYIVAEPGAaGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
AFD_YhfT-like cd17633
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...
213-546 2.62e-42

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain


Pssm-ID: 341288 [Multi-domain]  Cd Length: 320  Bit Score: 154.10  E-value: 2.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 213 YTGGTTGVAKGAMLTHRNMLANLEqVNATygpLLHPGKELVITAL-PLYHifALTMNCLLFIELGGQNVLITNPRDIPGL 291
Cdd:cd17633    7 FTSGTTGLPKAYYRSERSWIESFV-CNED---LFNISGEDAILAPgPLSH--SLFLYGAISALYLGGTFIGQRKFNPKSW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 292 VKELAKYPFTAMTGVNTLFNALLNNkEFQQLDFSTLhLSAGGGMP--VQQAVAERWVKLTgqyLLEGYGLTEcAPLVSVN 369
Cdd:cd17633   81 IRKINQYNATVIYLVPTMLQALART-LEPESKIKSI-FSSGQKLFesTKKKLKNIFPKAN---LIEFYGTSE-LSFITYN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 370 PHDIDYHSGSIGLPVPSTEAKLVDDEDNEVphgepGELCVRGPQVMLGYWQrpdaTDEIIKDGWLHTGDIAVMDDEGFLR 449
Cdd:cd17633  155 FNQESRPPNSVGRPFPNVEIEIRNADGGEI-----GKIFVKSEMVFSGYVR----GGFSNPDGWMSVGDIGYVDEEGYLY 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 450 IVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVkIFVVKKDpSLTEDALITFCRRQLTGYKVPKL 529
Cdd:cd17633  226 LVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIA-VALYSGD-KLTYKQLKRFLKQKLSRYEIPKK 303
                        330
                 ....*....|....*..
gi 489956626 530 VEFRDELPKSNVGKILR 546
Cdd:cd17633  304 IIFVDSLPYTSSGKIAR 320
PRK06018 PRK06018
putative acyl-CoA synthetase; Provisional
50-552 1.98e-41

putative acyl-CoA synthetase; Provisional


Pssm-ID: 235673 [Multi-domain]  Cd Length: 542  Bit Score: 156.84  E-value: 1.98e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLqEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:PRK06018  41 TYAQIHDRALKVSQAL-DRDGIKLGDRVATIAWNTWRHLEAWYGIMGIGAICHTVNPRLFPEQIAWIINHAEDRVVITDL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 NFAHTLEKVVektqvkhviltrmgDQLSTAKgtlvNFVVKYVKRLVPKYHLPDAISFRRALhAGYRMQYVKPEIVSEDLA 209
Cdd:PRK06018 120 TFVPILEKIA--------------DKLPSVE----RYVVLTDAAHMPQTTLKNAVAYEEWI-AEADGDFAWKTFDENTAA 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 210 FLQYTGGTTGVAKGAMLTHR-NMLANLEQVNAtyGPLLHPGKELVITALPLYHIFA--LTMNCllfiELGGQNVLITNPR 286
Cdd:PRK06018 181 GMCYTSGTTGDPKGVLYSHRsNVLHALMANNG--DALGTSAADTMLPVVPLFHANSwgIAFSA----PSMGTKLVMPGAK 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 DIPGLVKEL---AKYPFTAmtGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLtGQYLLEGYGLTECA 363
Cdd:PRK06018 255 LDGASVYELldtEKVTFTA--GVPTVWLMLLQYMEKEGLKLPHLKMVVCGGSAMPRSMIKAFEDM-GVEVRHAWGMTEMS 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 364 PL--VSVNPHDIDYHSGSI--------GLPVPSTEAKLVDDEDNEVPHG--EPGELCVRGPQVMLGYWQrpdATDEII-K 430
Cdd:PRK06018 332 PLgtLAALKPPFSKLPGDArldvlqkqGYPPFGVEMKITDDAGKELPWDgkTFGRLKVRGPAVAAAYYR---VDGEILdD 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 431 DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGE-AVKIFVVKKDPSLT 509
Cdd:PRK06018 409 DGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKWDErPLLIVQLKPGETAT 488
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 489956626 510 EDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06018 489 REEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALREQ 531
LC_FACS_euk1 cd17639
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...
49-458 5.78e-41

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.


Pssm-ID: 341294 [Multi-domain]  Cd Length: 507  Bit Score: 155.07  E-value: 5.78e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVnplY-TPRE--LEHQLNDSGAAAI 125
Cdd:cd17639    6 MSYAEVWERVLNFGRGLVE-LGLKPGDKVAIFAETRAEWLITALGCWSQNIPIVTV---YaTLGEdaLIHSLNETECSAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIVSNfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivS 205
Cdd:cd17639   82 FTDGK--------------------------------------------------------------------------P 87
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPgKELVITALPLYHIFALTM-NCLLFIelggqNVLI-- 282
Cdd:cd17639   88 DDLACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPELLGP-DDRYLAYLPLAHIFELAAeNVCLYR-----GGTIgy 161
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 TNPRDIPGLVK-----ELAKYPFTAMTGV----------------------NTLFNALLNNKEFQQLD-----------F 324
Cdd:cd17639  162 GSPRTLTDKSKrgckgDLTEFKPTLMVGVpaiwdtirkgvlaklnpmgglkRTLFWTAYQSKLKALKEgpgtplldelvF 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 325 STLHLSAG--------GGMPVQQAvAERWVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYhsGSIGLPVPSTEAKLVD-D 394
Cdd:cd17639  242 KKVRAALGgrlrymlsGGAPLSAD-TQEFLNIVLCPVIQGYGLTEtCAGGTVQDPGDLET--GRVGPPLPCCEIKLVDwE 318
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 395 EDNEVPHGEP--GELCVRGPQVMLGYWQRPDATDEIIK-DGWLHTGDIAVMDDEGFLRIVDRKKDMI 458
Cdd:cd17639  319 EGGYSTDKPPprGEILIRGPNVFKGYYKNPEKTKEAFDgDGWFHTGDIGEFHPDGTLKIIDRKKDLV 385
PLN02479 PLN02479
acetate-CoA ligase
12-555 7.93e-41

acetate-CoA ligase


Pssm-ID: 178097 [Multi-domain]  Cd Length: 567  Bit Score: 155.77  E-value: 7.93e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  12 DVPAeiNPDRYQSLIELF--EHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYL-QEGLGLqkGDRVALMMPNLLQYP 88
Cdd:PLN02479   9 DLPK--NAANYTALTPLWflERAAVVHPTRKSVVHGSVRYTWAQTYQRCRRLASALaKRSIGP--GSTVAVIAPNIPAMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  89 VALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVE------KTQVKHVILTRMGDQLSTAKGT 162
Cdd:PLN02479  85 EAHFGVPMAGAVVNCVNIRLNAPTIAFLLEHSKSEVVMVDQEFFTLAEEALKilaekkKSSFKPPLLIVIGDPTCDPKSL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 163 lvnfvvkyvkrlvpKYHLPD-AISFRRALHAG-YRMQYVKPEIVSEDLAfLQYTGGTTGVAKGAMLTHRNMLanleqVNA 240
Cdd:PLN02479 165 --------------QYALGKgAIEYEKFLETGdPEFAWKPPADEWQSIA-LGYTSGTTASPKGVVLHHRGAY-----LMA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 241 TYGPLL--HPGKELVITALPLYHI----FALTMNCLLfielgGQNVLItnpRDIP--GLVKELAKYPFTAMTGVNTLFNA 312
Cdd:PLN02479 225 LSNALIwgMNEGAVYLWTLPMFHCngwcFTWTLAALC-----GTNICL---RQVTakAIYSAIANYGVTHFCAAPVVLNT 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 313 LLNN-KEFQQLDFS-TLHLSAGGGMP---VQQAVAERWVKLTGQY-LLEGYG-LTECA--------PLVS---------- 367
Cdd:PLN02479 297 IVNApKSETILPLPrVVHVMTAGAAPppsVLFAMSEKGFRVTHTYgLSETYGpSTVCAwkpewdslPPEEqarlnarqgv 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 368 --VNPHDIDYHSGSIGLPVPSTEAKLvddednevphgepGELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDE 445
Cdd:PLN02479 377 ryIGLEGLDVVDTKTMKPVPADGKTM-------------GEIVMRGNMVMKGYLKNPKANEEAFANGWFHSGDLGVKHPD 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 446 GFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD-------PSLTEDaLITFCR 518
Cdd:PLN02479 444 GYIEIKDRSKDIIISGGENISSLEVENVVYTHPAVLEASVVARPDERWGESPCAFVTLKPgvdksdeAALAED-IMKFCR 522
                        570       580       590
                 ....*....|....*....|....*....|....*..
gi 489956626 519 RQLTGYKVPKLVEFrDELPKSNVGKILRRELRDEARA 555
Cdd:PLN02479 523 ERLPAYWVPKSVVF-GPLPKTATGKIQKHVLRAKAKE 558
PLN03102 PLN03102
acyl-activating enzyme; Provisional
211-557 8.86e-41

acyl-activating enzyme; Provisional


Pssm-ID: 215576 [Multi-domain]  Cd Length: 579  Bit Score: 155.56  E-value: 8.86e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 211 LQYTGGTTGVAKGAMLTHRNmlANLEQVNATYGPLLHPGKELVITaLPLYHIFALTMNCLLFIElGGQNVLITNPrDIPG 290
Cdd:PLN03102 191 LNYTSGTTADPKGVVISHRG--AYLSTLSAIIGWEMGTCPVYLWT-LPMFHCNGWTFTWGTAAR-GGTSVCMRHV-TAPE 265
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 291 LVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFST-LHLSAGGGMPvqQAVAERWVKLTGQYLLEGYGLTEC-APLVSV 368
Cdd:PLN03102 266 IYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGpVHVLTGGSPP--PAALVKKVQRLGFQVMHAYGLTEAtGPVLFC 343
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 369 NPHD------------IDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEP-GELCVRGPQVMLGYWQRPDATDEIIKDGWLH 435
Cdd:PLN03102 344 EWQDewnrlpenqqmeLKARQGVSILGLADVDVKNKETQESVPRDGKTmGEIVIKGSSIMKGYLKNPKATSEAFKHGWLN 423
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 436 TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLT------ 509
Cdd:PLN03102 424 TGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLEKGETTkedrvd 503
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489956626 510 -----EDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKV 557
Cdd:PLN03102 504 klvtrERDLIEYCRENLPHFMCPRKVVFLQELPKNGNGKILKPKLRDIAKGLV 556
PRK07638 PRK07638
acyl-CoA synthetase; Validated
38-550 1.20e-40

acyl-CoA synthetase; Validated


Pssm-ID: 236071 [Multi-domain]  Cd Length: 487  Bit Score: 153.78  E-value: 1.20e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKgdRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK07638  16 NKIAIKENDRVLTYKDWFESVCKVANWLNEKESKNK--TIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDELKERL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVIvsnfahtlekvvektqvkhviLTRMGDQLSTAKGTLVNfvVKYVKRLVPKYhLPDAISFRRALHAGYRMQ 197
Cdd:PRK07638  94 AISNADMIVT---------------------ERYKLNDLPDEEGRVIE--IDEWKRMIEKY-LPTYAPIENVQNAPFYMG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 YvkpeivsedlaflqyTGGTTGVAKGAMLTHRNMLANLeQVNATYGPLLHPGKELVITALpLYHIFALTMNCLLFIelgG 277
Cdd:PRK07638 150 F---------------TSGSTGKPKAFLRAQQSWLHSF-DCNVHDFHMKREDSVLIAGTL-VHSLFLYGAISTLYV---G 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 278 QNVLITnPRDIPGLVKE-LAKYPFTAMTGVNTLFNALLNNKEFqqLDFSTLHLSAGG--GMPVQQAVAERWVKLTgqyLL 354
Cdd:PRK07638 210 QTVHLM-RKFIPNQVLDkLETENISVMYTVPTMLESLYKENRV--IENKMKIISSGAkwEAEAKEKIKNIFPYAK---LY 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 355 EGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGWL 434
Cdd:PRK07638 284 EFYGASELSFVTALVDEESERRPNSVGRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIGGVLARELNADGWM 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 435 HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEavkIFVVKKDPSLTEDALI 514
Cdd:PRK07638 364 TVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGE---KPVAIIKGSATKQQLK 440
                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 489956626 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07638 441 SFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAK 476
A_NRPS_SidN3_like cd05918
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...
27-553 6.46e-40

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341242 [Multi-domain]  Cd Length: 481  Bit Score: 151.54  E-value: 6.46e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd05918    3 DLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRS-LGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYtPRE-LEHQLNDSGAAaIVIVSNfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdais 185
Cdd:cd05918   82 SH-PLQrLQEILQDTGAK-VVLTSS------------------------------------------------------- 104
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 186 frralhagyrmqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvnatYGPLLHPGKE---LVITA----LP 258
Cdd:cd05918  105 -------------------PSDAAYVIFTSGSTGKPKGVVIEHRALSTSALA----HGRALGLTSEsrvLQFASytfdVS 161
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 259 LYHIFAlTMNCllfielGGqNVLITNPRDIPGlvkELAKYpFTAMtGVNTLF-----NALLNNKEFQQLdfSTLHLsagG 333
Cdd:cd05918  162 ILEIFT-TLAA------GG-CLCIPSEEDRLN---DLAGF-INRL-RVTWAFltpsvARLLDPEDVPSL--RTLVL---G 223
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 334 GMPVQQAVAERWVKLTGqyLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTeAKLVD--DEDNEVPHGEPGELCVRG 411
Cdd:cd05918  224 GEALTQSDVDTWADRVR--LINAYGPAECTIAATVSPVVPSTDPRNIGRPLGAT-CWVVDpdNHDRLVPIGAVGELLIEG 300
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 412 PQVMLGYWQRPDATDEI-IKD-GWLH------------TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQH 477
Cdd:cd05918  301 PILARGYLNDPEKTAAAfIEDpAWLKqegsgrgrrlyrTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHLRQS 380
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 478 SGVLEVAAVGV--PSGSSGEAVKI-FVVKKDPSLTED------------------ALITFCRRQLTGYKVPKLVEFRDEL 536
Cdd:cd05918  381 LPGAKEVVVEVvkPKDGSSSPQLVaFVVLDGSSSGSGdgdslflepsdefralvaELRSKLRQRLPSYMVPSVFLPLSHL 460
                        570
                 ....*....|....*..
gi 489956626 537 PKSNVGKILRRELRDEA 553
Cdd:cd05918  461 PLTASGKIDRRALRELA 477
A_NRPS_TlmIV_like cd12114
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...
38-549 2.41e-39

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.


Pssm-ID: 341279 [Multi-domain]  Cd Length: 477  Bit Score: 149.73  E-value: 2.41e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd12114    2 DATAVICGDGTLTYGELAERARRVAGALKA-AGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVivsnfahtlekvVEKTQVKHVILTrmgdqlstakgtlvnfvvkyvkrlvpkyhlPDAISFRRALHAGYRMQ 197
Cdd:cd12114   81 ADAGARLVL------------TDGPDAQLDVAV------------------------------FDVLILDLDALAAPAPP 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYgpllHPGKELVITA-------LPLYHIFALTmncl 270
Cdd:cd12114  119 -PPVDVAPDDLAYVIFTSGSTGTPKGVMISHRAALNTILDINRRF----AVGPDDRVLAlsslsfdLSVYDIFGAL---- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 271 lfiELGGQNVLITNPRDI-PGLVKELA-KYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKL 348
Cdd:cd12114  190 ---SAGATLVLPDEARRRdPAHWAELIeRHGVTLWNSVPALLEMLLDVLEAAQALLPSLRLVLLSGDWIPLDLPARLRAL 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 349 TGQYLLEGYG-LTECA------PLVSVNPHDidyhsGSI--GLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYW 419
Cdd:cd12114  267 APDARLISLGgATEASiwsiyhPIDEVPPDW-----RSIpyGRPLANQRYRVLDPRGRDCPDWVPGELWIGGRGVALGYL 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDATDE---IIKDG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGsSG 494
Cdd:cd12114  342 GDPELTAArfvTHPDGerLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDP-GG 420
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 495 EAVKIFVV--KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12114  421 KRLAAFVVpdNDGTPIAPDALRAFLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477
A_NRPS_Cytc1-like cd17643
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...
38-549 2.62e-39

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341298 [Multi-domain]  Cd Length: 450  Bit Score: 149.38  E-value: 2.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17643    2 EAVAVVDEDRRLTYGELDARANRLARTLRA-EGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVivsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17643   81 ADSGPSLLL----------------------------------------------------------------------- 89
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yVKPEivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATY------------------------GPLLHpGKELV 253
Cdd:cd17643   90 -TDPD----DLAYVIYTSGSTGRPKGVVVSHANVLALFAATQRWFgfneddvwtlfhsyafdfsvweiwGALLH-GGRLV 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 254 ItalPLYHIfALTmncllfielggqnvlitnPRDIPGLVKELAkypFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG 333
Cdd:cd17643  164 V---VPYEV-ARS------------------PEDFARLLRDEG---VTVLNQTPSAFYQLVEAADRDGRDPLALRYVIFG 218
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 334 GMPVQQAVAERWVK---LTGQYLLEGYGLTECAPLVS---VNPHDIDYHSGS-IGLPVPSTEAKLVDDEDNEVPHGEPGE 406
Cdd:cd17643  219 GEALEAAMLRPWAGrfgLDRPQLVNMYGITETTVHVTfrpLDAADLPAAAASpIGRPLPGLRVYVLDADGRPVPPGVVGE 298
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 407 LCVRGPQVMLGYWQRPDATDEIIKDG--------WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHS 478
Cdd:cd17643  299 LYVSGAGVARGYLGRPELTAERFVANpfggpgsrMYRTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALATHP 378
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489956626 479 GVLEvAAVGVPSGSSGEA--VKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17643  379 SVRD-AAVIVREDEPGDTrlVAYVVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450
PRK09192 PRK09192
fatty acyl-AMP ligase;
34-501 2.05e-38

fatty acyl-AMP ligase;


Pssm-ID: 236403 [Multi-domain]  Cd Length: 579  Bit Score: 149.00  E-value: 2.05e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  34 RRYADQPAFV--------------------NMGEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK09192  15 RRYADFPTLVealdyaalgeagmnfydrrgQLEEALPYQTLRARAEAGARRLL-ALGLKPGDRVALIAETDGDFVEAFFA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  94 ILRAGMIVVnvnPLYTP-----RE-----LEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHViltrmgdqlstakGTL 163
Cdd:PRK09192  94 CQYAGLVPV---PLPLPmgfggREsyiaqLRGMLASAQPAAIITPDELLPWVNEATHGNPLLHV-------------LSH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 164 VNFvvkyvkrlvpkYHLPDAISfrrALhagyrmqyvkPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeQVNATYG 243
Cdd:PRK09192 158 AWF-----------KALPEADV---AL----------PRPTPDDIAYLQYSSGSTRFPRGVIITHRALMANL-RAISHDG 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 244 PLLHPGkELVITALPLYHIFALtMNCLLFIeLGGQ---NVLITNprdipglvkELAKYPF---------TAMTGVNTLFN 311
Cdd:PRK09192 213 LKVRPG-DRCVSWLPFYHDMGL-VGFLLTP-VATQlsvDYLPTR---------DFARRPLqwldlisrnRGTISYSPPFG 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 312 ALLNNKEFQQLDFSTLHLS----AGGG-----MPVQQAVAERW--VKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSI 380
Cdd:PRK09192 281 YELCARRVNSKDLAELDLScwrvAGIGadmirPDVLHQFAEAFapAGFDDKAFMPSYGLAEATLAVSFSPLGSGIVVEEV 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 381 ---------------------------GLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIKDGW 433
Cdd:PRK09192 361 drdrleyqgkavapgaetrrvrtfvncGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRDEESQDVLAADGW 440
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 434 LHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVL--EVAAVGVPSGsSGEAVKIFV 501
Cdd:PRK09192 441 LDTGDLGYLLD-GYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRsgDAAAFSIAQE-NGEKIVLLV 508
ACS-like cd17634
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...
33-545 3.34e-38

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341289 [Multi-domain]  Cd Length: 587  Bit Score: 148.49  E-value: 3.34e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  33 VRRYADQPAFVNMGE------VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17634   63 LRENGDRTAIIYEGDdtsqsrTISYRELHREVCRFAGTLLD-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFG 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAAIVIVSNFahtlekvVEKTQVkhVILTRMGDQLSTAKGTLVNFVVKYVKRLVPKYHLPDAISF 186
Cdd:cd17634  142 GFAPEAVAGRIIDSSSRLLITADGG-------VRAGRS--VPLKKNVDDALNPNVTSVEHVIVLKRTGSDIDWQEGRDLW 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 RRALHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNAtYGPLLHPGkELVITALPL------- 259
Cdd:cd17634  213 WRDLIAKASPEHQPEAMNAEDPLFILYTSGTTGKPKGVLHTTGGYLVYAATTMK-YVFDYGPG-DIYWCTADVgwvtghs 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 260 ---YHIFALTMNCLLF---------------IELGGQNVLITNPRDIPGLVKElakypftamtgvntlfnallNNKEFQQ 321
Cdd:cd17634  291 yllYGPLACGATTLLYegvpnwptparmwqvVDKHGVNILYTAPTAIRALMAA--------------------GDDAIEG 350
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 322 LDFSTLHLSAGGGMPVQQAVAERWVKLTGQY---LLEGYGLTECA-PLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDN 397
Cdd:cd17634  351 TDRSSLRILGSVGEPINPEAYEWYWKKIGKEkcpVVDTWWQTETGgFMITPLPGAIELKAGSATRPVFGVQPAVVDNEGH 430
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 398 EVPHGEPGELCVRG--PQVMLGYWQRPDATDEIIK---DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIED 472
Cdd:cd17634  431 PQPGGTEGNLVITDpwPGQTRTLFGDHERFEQTYFstfKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIES 510
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 473 VVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKK----DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKIL 545
Cdd:cd17634  511 VLVAHPKVAEAAVVGIPHAIKGQAPYAYVVLNhgvePSPELYAELRNWVRKEIGPLATPDVVHWVDSLPKTRSGKIM 587
PRK07769 PRK07769
long-chain-fatty-acid--CoA ligase; Validated
24-552 5.31e-38

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 181109 [Multi-domain]  Cd Length: 631  Bit Score: 148.34  E-value: 5.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  24 SLIELFEHSVRRYADQPA--FVNM-----GEV--MTFRKLEERSRAFAAYLQEGLglQKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK07769  22 NLVRHVERWAKVRGDKLAyrFLDFsterdGVArdLTWSQFGARNRAVGARLQQVT--KPGDRVAILAPQNLDYLIAFFGA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  95 LRAGMIVVnvnPLYTPRELEHqlndsgaaaivivsnfAHTLEKVVEKTQVKhVILTRMGdqlsTAKGtlvnfVVKYVKRL 174
Cdd:PRK07769 100 LYAGRIAV---PLFDPAEPGH----------------VGRLHAVLDDCTPS-AILTTTD----SAEG-----VRKFFRAR 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 175 VPKYH--------LPDAISfrralhagyrMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQV-NATYGPL 245
Cdd:PRK07769 151 PAKERprviavdaVPDEVG----------ATWVPPEANEDTIAYLQYTSGSTRIPAGVQITHLNLPTNVLQViDALEGQE 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 246 LHPGkelvITALPLYHIFALTMncLLFIELGGQNVLITNPRDI---PG-LVKELAKYPftamTGVNTLFNALLN------ 315
Cdd:PRK07769 221 GDRG----VSWLPFFHDMGLIT--VLLPALLGHYITFMSPAAFvrrPGrWIRELARKP----GGTGGTFSAAPNfafeha 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 316 -----NKEFQQ-LDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPHD-------IDYH 376
Cdd:PRK07769 291 aarglPKDGEPpLDLSNVKGLLNGSEPVSPASMRKFNEAFAPYGLPptaikpSYGMAEATLFVSTTPMDeeptviyVDRD 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 377 SGSIG--LPVPSTE-----------------AKLVDDE-DNEVPHGEPGELCVRGPQVMLGYWQRPDATDEIIK------ 430
Cdd:PRK07769 371 ELNAGrfVEVPADApnavaqvsagkvgvsewAVIVDPEtASELPDGQIGEIWLHGNNIGTGYWGKPEETAATFQnilksr 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 431 ------------DGWLHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLE---VAAVGVPSGSSGE 495
Cdd:PRK07769 451 lseshaegapddALWVRTGDYGVYFD-GELYITGRVKDLVIIDGRNHYPQDLEYTAQEATKALRtgyVAAFSVPANQLPQ 529
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 496 AV---KIFVVKKDPSLTEDALITFCRRQLTGYK---------------VPKLVEFRDEL-------PKSNVGKILRRELR 550
Cdd:PRK07769 530 VVfddSHAGLKFDPEDTSEQLVIVAERAPGAHKldpqpiaddiraaiaVRHGVTVRDVLlvpagsiPRTSSGKIARRACR 609

                 ..
gi 489956626 551 DE 552
Cdd:PRK07769 610 AA 611
PRK06060 PRK06060
p-hydroxybenzoic acid--AMP ligase FadD22;
36-556 5.68e-38

p-hydroxybenzoic acid--AMP ligase FadD22;


Pssm-ID: 180374 [Multi-domain]  Cd Length: 705  Bit Score: 149.03  E-value: 5.68e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  36 YADQPAFVnMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK06060  19 WYDRPAFY-AADVVTHGQIHDGAARLGEVLRN-RGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 116 QLNDSgAAAIVIVSNfahtleKVVEKTQVKHVIltRMGDQLSTAKgtlvnfvvkyvkrlvpkyhlpdaisfrRALHAGYr 195
Cdd:PRK06060  97 AARNT-EPALVVTSD------ALRDRFQPSRVA--EAAELMSEAA---------------------------RVAPGGY- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 196 mqyvkpEIVSED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQV--NATYgplLHPgKELVITALPLYHIFALTMNCLLF 272
Cdd:PRK06060 140 ------EPMGGDaLAYATYTSGTTGPPKAAIHRHADPLTFVDAMcrKALR---LTP-EDTGLCSARMYFAYGLGNSVWFP 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 273 IELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQldFSTLHLSAGGGMPVQQAVAERWVKLTGQY 352
Cdd:PRK06060 210 LATGGSAVINSAPVTPEAAAILSARFGPSVLYGVPNFFARVIDSCSPDS--FRSLRCVVSAGEALELGLAERLMEFFGGI 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 -LLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDA--TDEii 429
Cdd:PRK06060 288 pILDGIGSTEVGQTFVSNRVD-EWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSpvANE-- 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 430 kdGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLT 509
Cdd:PRK06060 365 --GWLDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATI 442
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489956626 510 EDALITFCRR----QLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAK 556
Cdd:PRK06060 443 DGSVMRDLHRgllnRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKQSPTK 493
LC_FACS_bac cd05932
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...
50-487 1.00e-36

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341255 [Multi-domain]  Cd Length: 508  Bit Score: 142.99  E-value: 1.00e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIvivs 129
Cdd:cd05932    8 TWGEVADKARRLAAALRA-LGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKAL---- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 nfahtlekvvektqvkhvILTRMGDQLSTAKGtlvnfvvkyVKRLVPKYHLP--DAISFRR---ALHAGYRMQYVKPEIV 204
Cdd:cd05932   83 ------------------FVGKLDDWKAMAPG---------VPEGLISISLPppSAANCQYqwdDLIAQHPPLEERPTRF 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 SEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllhPGKELVITALPLYHIFALTmncllFIELGG--QNVLI 282
Cdd:cd05932  136 PEQLATLIYTSGTTGQPKGVMLTFGSFAWAAQAGIEHIGT---EENDRMLSYLPLAHVTERV-----FVEGGSlyGGVLV 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 TNPRDIPGLVKELAKYPFTAMTGVN---TLF----------------------NALLNNKEFQQLDFSTLHLSAGGGMPV 337
Cdd:cd05932  208 AFAESLDTFVEDVQRARPTLFFSVPrlwTKFqqgvqdkipqqklnlllkipvvNSLVKRKVLKGLGLDQCRLAGCGSAPV 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 338 QQAVAErWVKLTGQYLLEGYGLTE-CAplVSVNPHDIDYHSGSIGLPVPSTEAKLVDDednevphgepGELCVRGPQVML 416
Cdd:cd05932  288 PPALLE-WYRSLGLNILEAYGMTEnFA--YSHLNYPGRDKIGTVGNAGPGVEVRISED----------GEILVRSPALMM 354
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489956626 417 GYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:cd05932  355 GYYKDPEATAEAFtADGFLRTGDKGELDADGNLTITGRVKDIFKTSkGKYVAPAPIENKLAEHDRVEMVCVIG 427
ACSBG_like cd05933
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ...
47-474 1.44e-36

Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341256 [Multi-domain]  Cd Length: 596  Bit Score: 143.65  E-value: 1.44e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  47 EVMTFRKLEERSRAFA-AYLQegLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAI 125
Cdd:cd05933    7 HTLTYKEYYEACRQAAkAFLK--LGLERFHGVGILGFNSPEWFIAAVGAIFAGGIAVGIYTTNSPEACQYVAETS-EANI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIVSNfAHTLEKVvekTQVKhviltrmgDQLSTAKGtlvnfVVKYvkRLVPKYHLPDAISFRRALHAGY---------RM 196
Cdd:cd05933   84 LVVEN-QKQLQKI---LQIQ--------DKLPHLKA-----IIQY--KEPLKEKEPNLYSWDEFMELGRsipdeqldaII 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 197 QYVKPEivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHP-GKELVITALPLYHIFALTMNCLLFIEL 275
Cdd:cd05933  145 SSQKPN----QCCTLIYTSGTTGMPKGVMLSHDNITWTAKAASQHMDLRPATvGQESVVSYLPLSHIAAQILDIWLPIKV 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 276 GGQnVLITNPRDIPG-LVKELAKYPFTAMTGV------------------------------------------------ 306
Cdd:cd05933  221 GGQ-VYFAQPDALKGtLVKTLREVRPTAFMGVprvwekiqekmkavgaksgtlkrkiaswakgvgletnlklmggespsp 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 307 --NTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQyLLEGYGLTECAPLVSVNpHDIDYHSGSIGLPV 384
Cdd:cd05933  300 lfYRLAKKLVFKKVRKALGLDRCQKFFTGAAPISRETLEFFLSLNIP-IMELYGMSETSGPHTIS-NPQAYRLLSCGKAL 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 385 PSTEAKLVDDEDNEVphgepGELCVRGPQVMLGYWQRPDATDEIIK-DGWLHTGDIAVMDDEGFLRIVDRKKDMILVS-G 462
Cdd:cd05933  378 PGCKTKIHNPDADGI-----GEICFWGRHVFMGYLNMEDKTEEAIDeDGWLHSGDLGKLDEDGFLYITGRIKELIITAgG 452
                        490
                 ....*....|..
gi 489956626 463 FNVYPNEIEDVV 474
Cdd:cd05933  453 ENVPPVPIEDAV 464
A_NRPS_LgrA-like cd17645
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...
27-549 8.20e-36

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.


Pssm-ID: 341300 [Multi-domain]  Cd Length: 440  Bit Score: 139.23  E-value: 8.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17645    2 QLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGK-GVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAaiVIVSNfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisf 186
Cdd:cd17645   81 DYPGERIAYMLADSSAK--ILLTN-------------------------------------------------------- 102
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 rralhagyrmqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVNATYGPLLHPGKELVITALPlYHIFALT 266
Cdd:cd17645  103 ------------------PDDLAYVIYTSGSTGLPKGVMIEHHN-LVNLCEWHRPYFGVTPADKSLVYASFS-FDASAWE 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 267 MncllFIELGGQNVLITNPRDIPGLVKELAKYPFTamTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAErwv 346
Cdd:cd17645  163 I----FPHLTAGAALHVVPSERRLDLDALNDYFNQ--EGITISFLPTGAAEQFMQLDNQSLRVLLTGGDKLKKIERK--- 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 347 kltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAkLVDDEDNEV-PHGEPGELCVRGPQVMLGYWQRPDAT 425
Cdd:cd17645  234 ---GYKLVNNYGPTENTVVATSFEIDKPYANIPIGKPIDNTRV-YILDEALQLqPIGVAGELCIAGEGLARGYLNRPELT 309
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 DE-IIKDGWL------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVK 498
Cdd:cd17645  310 AEkFIVHPFVpgermyRTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDADGRKYLV 389
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489956626 499 IFVVKKDPSLTEdALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17645  390 AYVTAPEEIPHE-ELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
A_NRPS_CmdD_like cd17652
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...
38-549 1.13e-35

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).


Pssm-ID: 341307 [Multi-domain]  Cd Length: 436  Bit Score: 138.54  E-value: 1.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17652    2 DAPAVVFGDETLTYAELNARANRLARLLAA-RGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVivsnfahtlekvvekTQVkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17652   81 ADARPALLL---------------TTP----------------------------------------------------- 92
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVNATYGPLlHPGKELVITALPLYHIFALTMnCLLFIElGG 277
Cdd:cd17652   93 --------DNLAYVIYTSGSTGRPKGVVVTHRG-LANLAAAQIAAFDV-GPGSRVLQFASPSFDASVWEL-LMALLA-GA 160
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 278 QNVLITNPRDIPG--LVKELAKYPFTAMTGVNTLFNALlnnKEFQQLDFSTLHLsagGGMPVQQAVAERWVKltGQYLLE 355
Cdd:cd17652  161 TLVLAPAEELLPGepLADLLREHRITHVTLPPAALAAL---PPDDLPDLRTLVV---AGEACPAELVDRWAP--GRRMIN 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 356 GYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKD--- 431
Cdd:cd17652  233 AYGPTETTVCATMAGPLPGGGVPPIGRPVPGTRVYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAErFVADpfg 312
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 432 ---GWLH-TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEvAAVGVPSGSSGEA--VKIFVVKKD 505
Cdd:cd17652  313 apgSRMYrTGDLARWRADGQLEFLGRADDQVKIRGFRIELGEVEAALTEHPGVAE-AVVVVRDDRPGDKrlVAYVVPAPG 391
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 489956626 506 PSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17652  392 AAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
23-543 1.40e-35

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 141.77  E-value: 1.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRY-ADQPAF--VNMGEvMTFRKLEERSRAFAAYLQEGLglQKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:PRK08043 204 ETLYEALLSAQYRYgAGKPCIedVNFTP-DSYRKLLKKTLFVGRILEKYS--VEGERIGLMLPNATISAAVIFGASLRRR 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 100 IVVNVNplYTP--RELEHQLNDSGAAAIVIVSNF------AHTLEKVvekTQVKHVILTRMGDQLSTAKGTLVNFvvkyv 171
Cdd:PRK08043 281 IPAMMN--YTAgvKGLTSAITAAEIKTIFTSRQFldkgklWHLPEQL---TQVRWVYLEDLKDDVTTADKLWIFA----- 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 172 KRLVPkyhlpdaisfRRAlhagyrMQYVKPEivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVN--ATYGPllhpg 249
Cdd:PRK08043 351 HLLMP----------RLA------QVKQQPE----DAALILFTSGSEGHPKGVVHSHKSLLANVEQIKtiADFTP----- 405
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 250 KELVITALPLYHIFALTMNCLLFIELGGQNVLITNP---RDIPGLVKELAkypFTAMTGVNTLfnaLLNNKEFQQ-LDFS 325
Cdd:PRK08043 406 NDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPlhyRIVPELVYDRN---CTVLFGTSTF---LGNYARFANpYDFA 479
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 326 TLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PhdIDYHSGSIGLPVPSTEAKLVddednEVP---H 401
Cdd:PRK08043 480 RLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINvP--MAAKPGTVGRILPGMDARLL-----SVPgieQ 552
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 402 GepGELCVRGPQVMLGY--------WQRPDATDE--IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIE 471
Cdd:PRK08043 553 G--GRLQLKGPNIMNGYlrvekpgvLEVPTAENArgEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVE 630
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 472 DVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVkkDPSLTEDALITFCRR----QLTgykVPKLVEFRDELPKSNVGK 543
Cdd:PRK08043 631 QLALGVSPDKQHATAIKSDASKGEALVLFTT--DSELTREKLQQYAREhgvpELA---VPRDIRYLKQLPLLGSGK 701
FACL_like_5 cd05924
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
205-543 3.65e-35

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341248 [Multi-domain]  Cd Length: 364  Bit Score: 135.59  E-value: 3.65e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 SEDLAFLQYTGGTTGVAKGAMLTH---RNML---ANLEQVNATYGPLLHPGKE-----LVITALPLYHifALTMNCLLFI 273
Cdd:cd05924    2 SADDLYILYTGGTTGMPKGVMWRQediFRMLmggADFGTGEFTPSEDAHKAAAaaagtVMFPAPPLMH--GTGSWTAFGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 274 ELGGQNVLITNPR-DIPGLVKELAKYPFTAMTGVNT-----LFNALLNNKEFqqlDFSTLHLSAGGGMPVQQAVAERWVK 347
Cdd:cd05924   80 LLGGQTVVLPDDRfDPEEVWRTIEKHKVTSMTIVGDamarpLIDALRDAGPY---DLSSLFAISSGGALLSPEVKQGLLE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 348 LTGQ-YLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTeaKLVDDEDNEVP--HGEPGELCVRGpQVMLGYWQRPDA 424
Cdd:cd05924  157 LVPNiTLVDAFGSSETGFTGSGHSAGSGPETGPFTRANPDT--VVLDDDGRVVPpgSGGVGWIARRG-HIPLGYYGDEAK 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 425 TDEIIK--DG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVkIF 500
Cdd:cd05924  234 TAETFPevDGvrYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEV-VA 312
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 489956626 501 VVKKDP--SLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:cd05924  313 VVQLREgaGVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
PRK05620 PRK05620
long-chain fatty-acid--CoA ligase;
47-550 3.89e-35

long-chain fatty-acid--CoA ligase;


Pssm-ID: 180167 [Multi-domain]  Cd Length: 576  Bit Score: 139.53  E-value: 3.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  47 EVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIV 126
Cdd:PRK05620  37 EQTTFAAIGARAAALAHALHDELGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEVIV 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 127 IVSNFAHTLEKVVEKT-QVKHVILTRMGDQLSTAKgtlvnfvvkyvkrlvpkyHLPDAISFR--RALHAGYRMQYVKPEI 203
Cdd:PRK05620 117 ADPRLAEQLGEILKECpCVRAVVFIGPSDADSAAA------------------HMPEGIKVYsyEALLDGRSTVYDWPEL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 VSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGkELVITALPLYHIFALTMNCLLFieLGGQNVLIT 283
Cdd:PRK05620 179 DETTAAAICYSTGTTGAPKGVVYSHRSLYLQSLSLRTTDSLAVTHG-ESFLCCVPIYHVLSWGVPLAAF--MSGTPLVFP 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 284 NPRDIPglvKELAKYPFTAMT----GVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGL 359
Cdd:PRK05620 256 GPDLSA---PTLAKIIATAMPrvahGVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAVPPILIKAWEERYGVDVVHVWGM 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 360 TECAPL--VSVNPHDID------YHSGSIGLPVpSTEAKLVDD-------EDNEvphgepGELCVRGPQVMLGYWQRP-- 422
Cdd:PRK05620 333 TETSPVgtVARPPSGVSgearwaYRVSQGRFPA-SLEYRIVNDgqvmestDRNE------GEIQVRGNWVTASYYHSPte 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 423 ---------------DATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:PRK05620 406 egggaastfrgedveDANDRFTADGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIG 485
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 488 VPSGSSGE---AVKIFVVKKDPSL-TEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK05620 486 YPDDKWGErplAVTVLAPGIEPTReTAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDLR 552
PrpE cd05967
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...
50-556 4.10e-35

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.


Pssm-ID: 341271 [Multi-domain]  Cd Length: 617  Bit Score: 139.76  E-value: 4.10e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd05967   84 TYAELLDEVSRLAGVLRK-LGVVKGDRVIIYMPMIPEAAIAMLACARIGAIHSVVFGGFAAKELASRIDDAKPKLIVTAS 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 ---------NFAHTLEKVVEKTQVK--HVILTRMGDqlstakgtlvnfvvkyvKRLVPKYHLPDaISFRRALHAGYRMQY 198
Cdd:cd05967  163 cgiepgkvvPYKPLLDKALELSGHKphHVLVLNRPQ-----------------VPADLTKPGRD-LDWSELLAKAEPVDC 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 199 VKpeIVSEDLAFLQYTGGTTGVAKG--------AMLTHRNMlANLEQVNA-------------------TYGPLLHPGKE 251
Cdd:cd05967  225 VP--VAATDPLYILYTSGTTGKPKGvvrdngghAVALNWSM-RNIYGIKPgdvwwaasdvgwvvghsyiVYGPLLHGATT 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 252 LVITALPLYhifalTMNCLLF---IELGGQNVLITNPRDIPGLVKE------LAKYPFTAMTgvnTLFNAllnnkeFQQL 322
Cdd:cd05967  302 VLYEGKPVG-----TPDPGAFwrvIEKYQVNALFTAPTAIRAIRKEdpdgkyIKKYDLSSLR---TLFLA------GERL 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 323 DFSTLHlsagggmpvqqavaerWV-KLTGQYLLEGYGLTE-----CAPLVSVNPHDIdyHSGSIGLPVPSTEAKLVDDED 396
Cdd:cd05967  368 DPPTLE----------------WAeNTLGVPVIDHWWQTEtgwpiTANPVGLEPLPI--KAGSPGKPVPGYQVQVLDEDG 429
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 397 NEVPHGEPGELCVRGP---QVMLGYWQRPDATDEII---KDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEI 470
Cdd:cd05967  430 EPVGPNELGNIVIKLPlppGCLLTLWKNDERFKKLYlskFPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEM 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 471 EDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTED----ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKIL 545
Cdd:cd05967  510 EESVLSHPAVAECAVVGVRDELKGQVPLGLVVlKEGVKITAEelekELVALVREQIGPVAAFRLVIFVKRLPKTRSGKIL 589
                        570
                 ....*....|.
gi 489956626 546 RRELRDEARAK 556
Cdd:cd05967  590 RRTLRKIADGE 600
A_NRPS_ProA cd17656
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...
38-549 4.22e-35

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341311 [Multi-domain]  Cd Length: 479  Bit Score: 137.99  E-value: 4.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17656    3 DAVAVVFENQKLTYRELNERSNQLARFLRE-KGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVivsnfahtlekvvekTQVKHViltrmgDQLSTAKGTlvnfvvkyvkrlvpkyHLPDAISFRRALHagyrmQ 197
Cdd:cd17656   82 LDSGVRVVL---------------TQRHLK------SKLSFNKST----------------ILLEDPSISQEDT-----S 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 YVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMlANLEQVNATYGPLLHPGKELVITALPL---YH-IFAltmnCLLFi 273
Cdd:cd17656  120 NIDYINNSDDLLYIIYTSGTTGKPKGVQLEHKNM-VNLLHFEREKTNINFSDKVLQFATCSFdvcYQeIFS----TLLS- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 274 elGGQNVLITNP--RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL-HLSAGGGMPVQQAVAERWVKLTG 350
Cdd:cd17656  194 --GGTLYIIREEtkRDVEQLFDLVKRHNIEVVFLPVAFLKFIFSEREFINRFPTCVkHIITAGEQLVITNEFKEMLHEHN 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 351 QYLLEGYGLTEcAPLVS---VNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDAT-D 426
Cdd:cd17656  272 VHLHNHYGPSE-THVVTtytINPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTaE 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 427 EIIKDGW------LHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEvAAVGVPSGSSGEAVKIF 500
Cdd:cd17656  351 KFFPDPFdpnermYRTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSE-AVVLDKADDKGEKYLCA 429
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 489956626 501 VVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17656  430 YFVMEQELNISQLREYLAKQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
PRK12316 PRK12316
peptide synthase; Provisional
7-549 5.05e-35

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 141.63  E-value: 5.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626    7 NRYPADVPAEinpdryQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQ 86
Cdd:PRK12316 4541 NRTDAGYPAT------RCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIA-RGVGPEVLVGIAMERSAE 4613
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   87 YPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVivsnfahtlekvvekTQvkhvilTRMGDQLSTAKGTlvn 165
Cdd:PRK12316 4614 MMVGLLAVLKAGGAYVPLDPEY-PRErLAYMMEDSGAALLL---------------TQ------SHLLQRLPIPDGL--- 4668
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  166 fvvkyvkrlvpkyhlpDAISFRRALH-AGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGp 244
Cdd:PRK12316 4669 ----------------ASLALDRDEDwEGFPAHDPAVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYE- 4731
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  245 LLHPGKELVITALPlyhiFALTMNCLLFIELGGQNVLITNPR--DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEfQQL 322
Cdd:PRK12316 4732 LTPDDRVLQFMSFS----FDGSHEGLYHPLINGASVVIRDDSlwDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAE-RDG 4806
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  323 DFSTLHLSAGGGMPVQQAVAER-WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTEAKLVDDEDN 397
Cdd:PRK12316 4807 EPPSLRVYCFGGEAVAQASYDLaWRALKPVYLFNGYGPTETTVTVLLWKARDGDACGAaympIGTPLGNRSGYVLDGQLN 4886
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  398 EVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKD------GWLH-TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PRK12316 4887 PLPVGVAGELYLGGEGVARGYLERPALTAErFVPDpfgapgGRLYrTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGE 4966
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  470 IEDVVMQHSGVLEVAAVGVPsGSSGEAVKIFVVKKDPSLTE---------DALITFCRRQLTGYKVPKLVEFRDELPKSN 540
Cdd:PRK12316 4967 IEARLREHPAVREAVVIAQE-GAVGKQLVGYVVPQDPALADadeaqaelrDELKAALRERLPEYMVPAHLVFLARMPLTP 5045

                  ....*....
gi 489956626  541 VGKILRREL 549
Cdd:PRK12316 5046 NGKLDRKAL 5054
A_NRPS_MycA_like cd05908
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...
206-552 1.63e-34

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341234 [Multi-domain]  Cd Length: 499  Bit Score: 136.46  E-value: 1.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQV-NATYGPLlhpgKELVITALPLYHIFALtMNCLLFIELGGQNVLITN 284
Cdd:cd05908  106 DELAFIQFSSGSTGDPKGVMLTHENLVHNMFAIlNSTEWKT----KDRILSWMPLTHDMGL-IAFHLAPLIAGMNQYLMP 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 285 PRDI---PGL-VKELAKYPFTAMTGVN---TLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQY----- 352
Cdd:cd05908  181 TRLFirrPILwLKKASEHKATIVSSPNfgyKYFLKTLKPEKANDWDLSSIRMILNGAEPIDYELCHEFLDHMSKYglkrn 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 -LLEGYGLTECAPLVSVNPHDIDY------HSG---------------------SIGLPVPSTEAKLVDDEDNEVPHGEP 404
Cdd:cd05908  261 aILPVYGLAEASVGASLPKAQSPFktitlgRRHvthgepepevdkkdsecltfvEVGKPIDETDIRICDEDNKILPDGYI 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 405 GELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVL-- 481
Cdd:cd05908  341 GHIQIRGKNVTPGYYNNPEATAKVFtDDGWLKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHDIERIAEELEGVElg 419
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 482 EVAAVGV-PSGSSGEAVKIFVVKKDpslTEDALITFCRR------QLTGYKVPKLVEFRdELPKSNVGKILRRELRDE 552
Cdd:cd05908  420 RVVACGVnNSNTRNEEIFCFIEHRK---SEDDFYPLGKKikkhlnKRGGWQINEVLPIR-RIPKTTSGKVKRYELAQR 493
ACS cd05966
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...
33-553 2.48e-34

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.


Pssm-ID: 341270 [Multi-domain]  Cd Length: 608  Bit Score: 137.31  E-value: 2.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  33 VRRYADQPAF------VNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd05966   63 LKERGDKVAIiwegdePDQSRTITYRELLREVCRFANVLKS-LGVKKGDRVAIYMPMIPELVIAMLACARIGAVHSVVFA 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYTPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVEK-----TQVKHVIltrmgdqlstakgtlvnfVVKYVKRLVP 176
Cdd:cd05966  142 GFSAESLADRINDAQCKLVITADGGyrggkVIPLKEIVDEalekcPSVEKVL------------------VVKRTGGEVP 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 177 K-------YHlpDAIsfrralhAGYRMqYVKPEIV-SEDLAFLQYTGGTTGVAKG-----------AMLTHRNML----- 232
Cdd:cd05966  204 MtegrdlwWH--DLM-------AKQSP-ECEPEWMdSEDPLFILYTSGSTGKPKGvvhttggyllyAATTFKYVFdyhpd 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 233 ------ANLEQVNA----TYGPLLHPGKELVITALPLYHIFALTMNcllFIELGGQNVLITNPRDIPGLVKELAKYPfta 302
Cdd:cd05966  274 diywctADIGWITGhsyiVYGPLANGATTVMFEGTPTYPDPGRYWD---IVEKHKVTIFYTAPTAIRALMKFGDEWV--- 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 303 mtgvntlfnallnnkefQQLDFSTLHLSAGGGMPVQqavAERWvkltgQYLLEGYGLTEC----------------APLv 366
Cdd:cd05966  348 -----------------KKHDLSSLRVLGSVGEPIN---PEAW-----MWYYEVIGKERCpivdtwwqtetggimiTPL- 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 367 svnPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGP-QVML------------GYWQR-PdatdeiikdG 432
Cdd:cd05966  402 ---PGATPLKPGSATRPFFGIEPAILDEEGNEVEGEVEGYLVIKRPwPGMArtiygdheryedTYFSKfP---------G 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 433 WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKD-----PS 507
Cdd:cd05966  470 YYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAFVTLKDgeepsDE 549
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 489956626 508 LTEDaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05966  550 LRKE-LRKHVRKEIGPIATPDKIQFVPGLPKTRSGKIMRRILRKIA 594
PRK05850 PRK05850
acyl-CoA synthetase; Validated
24-548 3.12e-34

acyl-CoA synthetase; Validated


Pssm-ID: 235624 [Multi-domain]  Cd Length: 578  Bit Score: 136.61  E-value: 3.12e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  24 SLIELFEHSVRRYADQPAFVNM---------GEVMTFRKLEERSRAFAAYLQEgLGlQKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK05850   2 SVPSLLRERASLQPDDAAFTFIdyeqdpagvAETLTWSQLYRRTLNVAEELRR-HG-STGDRAVILAPQGLEYIVAFLGA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  95 LRAGMIVVnvnPLYTPRELEHQ------LNDSGAAAIvivsnfahtlekvvektqvkhviltrmgdqLSTAKgtLVNFVV 168
Cdd:PRK05850  80 LQAGLIAV---PLSVPQGGAHDervsavLRDTSPSVV------------------------------LTTSA--VVDDVT 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 169 KYVKRL----VPKYHLPDAISFRRALhagyrmqyvKPEIVSEDL---AFLQYTGGTTGVAKGAMLTHRNMLANLEQVNAT 241
Cdd:PRK05850 125 EYVAPQpgqsAPPVIEVDLLDLDSPR---------GSDARPRDLpstAYLQYTSGSTRTPAGVMVSHRNVIANFEQLMSD 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 242 YgpLLHPGKEL-----VITALPLYHIFALTMNCLLFIeLGGQNVLITNP--------RdipgLVKELAKYP--FTA---- 302
Cdd:PRK05850 196 Y--FGDTGGVPppdttVVSWLPFYHDMGLVLGVCAPI-LGGCPAVLTSPvaflqrpaR----WMQLLASNPhaFSAapnf 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 303 -------------MTGvntlfnallnnkefqqLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLE------GYGLTECA 363
Cdd:PRK05850 269 afelavrktsdddMAG----------------LDLGGVLGIISGSERVHPATLKRFADRFAPFNLRetairpSYGLAEAT 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 364 PLVSVNPH-------DIDYHSGSIGLPVP----------------STEAKLVDDEDN-EVPHGEPGELCVRGPQVMLGYW 419
Cdd:PRK05850 333 VYVATREPgqppesvRFDYEKLSAGHAKRcetgggtplvsygsprSPTVRIVDPDTCiECPAGTVGEIWVHGDNVAAGYW 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDATDEI-----------IKDG-WLHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVlEVAAVG 487
Cdd:PRK05850 413 QKPEETERTfgatlvdpspgTPEGpWLRTGDLGFISE-GELFIVGRIKDLLIVDGRNHYPDDIEATIQEITGG-RVAAIS 490
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 488 VPSGSSGEAVKIFVVKKDPSLTEDALITFC--RRQLT-------GYKVPKLVEF-RDELPKSNVGKILRRE 548
Cdd:PRK05850 491 VPDDGTEKLVAIIELKKRGDSDEEAMDRLRtvKREVTsaiskshGLSVADLVLVaPGSIPITTSGKIRRAA 561
PRK12467 PRK12467
peptide synthase; Provisional
23-549 3.83e-34

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 138.76  E-value: 3.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK12467  512 DCVHQLIEAQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAA-GVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYV 590
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  103 NVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVEKTQVKHVILTRMGDQLSTAKGtlvnfvvkyvkrlvpkyHLP 181
Cdd:PRK12467  591 PLDPEY-PQDrLAYMLDDSGVRLLLTQS---HLLAQLPVPAGLRSLCLDEPADLLCGYSG-----------------HNP 649
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  182 DaisfrralhagyrmqyvkPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVNATYGPLLhpgkelVITALPLYH 261
Cdd:PRK12467  650 E------------------VALDPDNLAYVIYTSGSTGQPKGVAISHGA-LANYVCVIAERLQLA------ADDSMLMVS 704
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  262 IFALTMNCL-LFIELG-GQNVLITNP---RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQ-LDFSTLHLsagGGM 335
Cdd:PRK12467  705 TFAFDLGVTeLFGALAsGATLHLLPPdcaRDAEAFAALMADQGVTVLKIVPSHLQALLQASRVALpRPQRALVC---GGE 781
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  336 PVQQAVAERWVKLT-GQYLLEGYGLTECAPLVSVNP---HDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRG 411
Cdd:PRK12467  782 ALQVDLLARVRALGpGARLINHYGPTETTVGVSTYElsdEERDFGNVPIGQPLANLGLYILDHYLNPVPVGVVGELYIGG 861
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  412 PQVMLGYWQRPDATDE-IIKD------GWLH-TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEv 483
Cdd:PRK12467  862 AGLARGYHRRPALTAErFVPDpfgadgGRLYrTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVRE- 940
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489956626  484 AAVGVPSGSSGEAVKIFVVKK------DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12467  941 AVVLAQPGDAGLQLVAYLVPAavadgaEHQATRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKAL 1012
PRK09274 PRK09274
peptide synthase; Provisional
49-509 1.20e-33

peptide synthase; Provisional


Pssm-ID: 236443 [Multi-domain]  Cd Length: 552  Bit Score: 134.64  E-value: 1.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAA-IVI 127
Cdd:PRK09274  42 LSFAELDARSDAIAHGLNA-AGIGRGMRAVLMVTPSLEFFALTFALFKAGAVPVLVDPGMGIKNLKQCLAEAQPDAfIGI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 128 vsnfahtlekvvEKTQVKHVILTRmgdqlstAKGTlvnfvvkyVKRLVP--KYHLPDAISFRRALH----AGYRMQYVKP 201
Cdd:PRK09274 121 ------------PKAHLARRLFGW-------GKPS--------VRRLVTvgGRLLWGGTTLATLLRdgaaAPFPMADLAP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 202 EivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpLLHPGKELVitALPLYHIFALTmncllfieLGGQNVL 281
Cdd:PRK09274 174 D----DMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYG-IEPGEIDLP--TFPLFALFGPA--------LGMTSVI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 282 --------IT-NPRDIpglVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKL--TG 350
Cdd:PRK09274 239 pdmdptrpATvDPAKL---FAAIERYGVTNLFGSPALLERLGRYGEANGIKLPSLRRVISAGAPVPIAVIERFRAMlpPD 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 351 QYLLEGYGLTECAPLVSVNPHDI--------DYHSGS-IGLPVPSTEAKLVD---------DEDNEVPHGEPGELCVRGP 412
Cdd:PRK09274 316 AEILTPYGATEALPISSIESREIlfatraatDNGAGIcVGRPVDGVEVRIIAisdapipewDDALRLATGEIGEIVVAGP 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 413 QVMLGYWQRPDATDEI-IKDG----WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:PRK09274 396 MVTRSYYNRPEATRLAkIPDGqgdvWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSALVG 475
                        490       500
                 ....*....|....*....|..
gi 489956626 488 VPSGssGEAVKIFVVKKDPSLT 509
Cdd:PRK09274 476 VGVP--GAQRPVLCVELEPGVA 495
entE PRK10946
(2,3-dihydroxybenzoyl)adenylate synthase;
38-557 2.99e-33

(2,3-dihydroxybenzoyl)adenylate synthase;


Pssm-ID: 236803 [Multi-domain]  Cd Length: 536  Bit Score: 133.19  E-value: 2.99e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGmiVVNVNPLYTPRELEhqL 117
Cdd:PRK10946  38 DAIAVICGERQFSYRELNQASDNLACSLRRQ-GIKPGDTALVQLGNVAEFYITFFALLKLG--VAPVNALFSHQRSE--L 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 N---DSGAAAIVIVSNfahtlekvvektqvKHVILT--RMGDQLSTAKGTLvnfvvkyvkRLVPKYHLPDAISFRRALHA 192
Cdd:PRK10946 113 NayaSQIEPALLIADR--------------QHALFSddDFLNTLVAEHSSL---------RVVLLLNDDGEHSLDDAINH 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 193 GYRMQYVKPEIVSEdLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELvITALPLYHIFALTM-NCLL 271
Cdd:PRK10946 170 PAEDFTATPSPADE-VAFFQLSGGSTGTPKLIPRTHNDYYYSVRRSVEICG--FTPQTRY-LCALPAAHNYPMSSpGALG 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 272 FIELGGQNVLITNPRdiPGLVKEL-AKYPFTaMT-----GVNTLFNALLNNKEFQQLdfSTLHLSAGGGMPVQQAVAERW 345
Cdd:PRK10946 246 VFLAGGTVVLAPDPS--ATLCFPLiEKHQVN-VTalvppAVSLWLQAIAEGGSRAQL--ASLKLLQVGGARLSETLARRI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VKLTGQYLLEGYGLTEcaPLVSV----NPHDIDYHSGsiGLPV-PSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQ 420
Cdd:PRK10946 321 PAELGCQLQQVFGMAE--GLVNYtrldDSDERIFTTQ--GRPMsPDDEVWVADADGNPLPQGEVGRLMTRGPYTFRGYYK 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 421 RPD----ATDEiikDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEA 496
Cdd:PRK10946 397 SPQhnasAFDA---NGFYCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEDELMGEK 473
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489956626 497 VKIFVVKKDPsLTEDALITFCRRQ-LTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKV 557
Cdd:PRK10946 474 SCAFLVVKEP-LKAVQLRRFLREQgIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534
LC_FACS_bac1 cd17641
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...
47-457 3.38e-33

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341296 [Multi-domain]  Cd Length: 569  Bit Score: 133.70  E-value: 3.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  47 EVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLlqyPVALFGILRAGMIVVNVNPLYT---PRELEHQLNDSGAA 123
Cdd:cd17641   10 QEFTWADYADRVRAFALGLLA-LGVGRGDVVAILGDNR---PEWVWAELAAQAIGALSLGIYQdsmAEEVAYLLNYTGAR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 124 AIVivsnfahtlekVVEKTQVKHVIltRMGDQLStakgtLVNFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEI 203
Cdd:cd17641   86 VVI-----------AEDEEQVDKLL--EIADRIP-----SVRYVIYCDPRGMRKYDDPRLISFEDVVALGRALDRRDPGL 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 VS--------EDLAFLQYTGGTTGVAKGAMLTHRNMLANlEQVNATYGPLlHPGKElVITALPL----YHIFALTM---- 267
Cdd:cd17641  148 YErevaagkgEDVAVLCTTSGTTGKPKLAMLSHGNFLGH-CAAYLAADPL-GPGDE-YVSVLPLpwigEQMYSVGQalvc 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 268 -NCLLFIELG----------GQNVLITNPRDIPGLVKEL-------------------------------AKYPFTAMTG 305
Cdd:cd17641  225 gFIVNFPEEPetmmedlreiGPTFVLLPPRVWEGIAADVrarmmdatpfkrfmfelgmklglraldrgkrGRPVSLWLRL 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 306 VNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAeRWVKLTGQYLLEGYGLTECAPLVSVNP-HDIDYHSgsIGLPV 384
Cdd:cd17641  305 ASWLADALLFRPLRDRLGFSRLRSAATGGAALGPDTF-RFFHAIGVPLKQLYGQTELAGAYTVHRdGDVDPDT--VGVPF 381
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489956626 385 PSTEAKLVddednevphgEPGELCVRGPQVMLGYWQRPDATDE-IIKDGWLHTGDIAVMDDEGFLRIVDRKKDM 457
Cdd:cd17641  382 PGTEVRID----------EVGEILVRSPGVFVGYYKNPEATAEdFDEDGWLHTGDAGYFKENGHLVVIDRAKDV 445
PRK05691 PRK05691
peptide synthase; Validated
15-550 9.45e-33

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 134.53  E-value: 9.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   15 AEINPDRYqslielfehSVRRYADQPafvNMGEVMTFRKLEERSRAFAAYLQEGLGLqkGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK05691   19 AAQTPDRL---------ALRFLADDP---GEGVVLSYRDLDLRARTIAAALQARASF--GDRAVLLFPSGPDYVAAFFGC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   95 LRAGMIVVnvnPLYTPREL--EHQLNdsgaaaivIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLVNfvvkyVK 172
Cdd:PRK05691   85 LYAGVIAV---PAYPPESArrHHQER--------LLSIIADAEPRLLLTVADLRDSLLQMEELAAANAPELLC-----VD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  173 RLVPkyhlpdaisfrrALHAGYRmqyvKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPgKEL 252
Cdd:PRK05691  149 TLDP------------ALAEAWQ----EPALQPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNP-DDV 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  253 VITALPLYHIFALTMNCLLFIELGGQNVLITnprdiPGL--------VKELAKYPFTAMTGVN---TLFNALLNNKEFQQ 321
Cdd:PRK05691  212 IVSWLPLYHDMGLIGGLLQPIFSGVPCVLMS-----PAYflerplrwLEAISEYGGTISGGPDfayRLCSERVSESALER 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  322 LDFSTLHLSAGGGMPVQQ----AVAERWVK--LTGQYLLEGYGLTECAPLVSVNPH-------DIDYHS----------G 378
Cdd:PRK05691  287 LDLSRWRVAYSGSEPIRQdsleRFAEKFAAcgFDPDSFFASYGLAEATLFVSGGRRgqgipalELDAEAlarnraepgtG 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  379 SI----GLPVPSTEAKLVDDEDNEV-PHGEPGELCVRGPQVMLGYWQRPDATDEII--KDG--WLHTGDIAVMDDeGFLR 449
Cdd:PRK05691  367 SVlmscGRSQPGHAVLIVDPQSLEVlGDNRVGEIWASGPSIAHGYWRNPEASAKTFveHDGrtWLRTGDLGFLRD-GELF 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  450 IVDRKKDMILVSGFNVYPNEIEDVVMQHSGVL---EVAAVGVP-SGSSGEAVKIFVVKK-DPSLTEDALITFCRRQLTG- 523
Cdd:PRK05691  446 VTGRLKDMLIVRGHNLYPQDIEKTVEREVEVVrkgRVAAFAVNhQGEEGIGIAAEISRSvQKILPPQALIKSIRQAVAEa 525
                         570       580       590
                  ....*....|....*....|....*....|
gi 489956626  524 -YKVPKLVEFRD--ELPKSNVGKILRRELR 550
Cdd:PRK05691  526 cQEAPSVVLLLNpgALPKTSSGKLQRSACR 555
PRK12476 PRK12476
putative fatty-acid--CoA ligase; Provisional
24-552 1.54e-32

putative fatty-acid--CoA ligase; Provisional


Pssm-ID: 171527 [Multi-domain]  Cd Length: 612  Bit Score: 132.17  E-value: 1.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  24 SLIELFEHSVRRYADQPAF-------VNMGEV--MTFRKLEERSRAFAAYLQEGLglQKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK12476  35 TLISLIERNIANVGDTVAYryldhshSAAGCAveLTWTQLGVRLRAVGARLQQVA--GPGDRVAILAPQGIDYVAGFFAA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  95 LRAGMIVVnvnPLYTPRELEHqlndsgaaaivivsnfAHTLEKVVEKTQvKHVILTRmgdqlSTAKGTLVNFVVKYVKRL 174
Cdd:PRK12476 113 IKAGTIAV---PLFAPELPGH----------------AERLDTALRDAE-PTVVLTT-----TAAAEAVEGFLRNLPRLR 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 175 VPKYHLPDAISFRRAlhagyrMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpLLHPGKELVi 254
Cdd:PRK12476 168 RPRVIAIDAIPDSAG------ESFVPVELDTDDVSHLQYTSGSTRPPVGVEITHRAVGTNLVQMILSID-LLDRNTHGV- 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 255 TALPLYHIFALTMncLLFIELGGQNVLITNP----RDIPGLVKELAK---------------YPFTAMTGVntlfnalln 315
Cdd:PRK12476 240 SWLPLYHDMGLSM--IGFPAVYGGHSTLMSPtafvRRPQRWIKALSEgsrtgrvvtaapnfaYEWAAQRGL--------- 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 316 NKEFQQLDFSTLHLsAGGGMPVQQAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPHD-------IDYH---SG- 378
Cdd:PRK12476 309 PAEGDDIDLSNVVL-IIGSEPVSIDAVTTFNKAFAPYGLPrtafkpSYGIAEATLFVATIAPDaepsvvyLDREqlgAGr 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 379 ---------------SIGLPVPSTEAKLVD-DEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEI-------------- 428
Cdd:PRK12476 388 avrvaadapnavahvSCGQVARSQWAVIVDpDTGAELPDGEVGEIWLHGDNIGRGYWGRPEETERTfgaklqsrlaegsh 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 429 -----IKDGWLHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLE---VAAVGVPSGSSGEAVKIF 500
Cdd:PRK12476 468 adgaaDDGTWLRTGDLGVYLD-GELYITGRIADLIVIDGRNHYPQDIEATVAEASPMVRrgyVTAFTVPAEDNERLVIVA 546
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 501 -----VVKKDPSLTEDAL-ITFCRRQLTGYKVPKLVEfRDELPKSNVGKILRRELRDE 552
Cdd:PRK12476 547 eraagTSRADPAPAIDAIrAAVSRRHGLAVADVRLVP-AGAIPRTTSGKLARRACRAQ 603
A_NRPS_PvdJ-like cd17649
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...
38-550 1.64e-32

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341304 [Multi-domain]  Cd Length: 450  Bit Score: 129.80  E-value: 1.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17649    2 DAVALVFGDQSLSYAELDARANRLAHRLRA-LGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAaaivivsnfahtlekvvektqvkHVILTRMGDQLstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17649   81 EDSGA-----------------------GLLLTHHPRQL----------------------------------------- 96
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yvkpeivsedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELvitaLPLYHI-FALTMNCLLFIELG 276
Cdd:cd17649   97 -----------AYVIYTSGSTGTPKGVAVSHGPLAAHCQATAERYG--LTPGDRE----LQFASFnFDGAHEQLLPPLIC 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 277 GQNVLI------TNPRDIPGLVKELakypftamtGVNT-------LFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAE 343
Cdd:cd17649  160 GACVVLrpdelwASADELAEMVREL---------GVTVldlppayLQQLAEEADRTGDGRPPSLRLYIFGGEALSPELLR 230
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 344 RWVKlTGQYLLEGYGLTEC--APLVSVNPHDIDYHSGS--IGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYW 419
Cdd:cd17649  231 RWLK-APVRLFNAYGPTEAtvTPLVWKCEAGAARAGASmpIGRPLGGRSAYILDADLNPVPVGVTGELYIGGEGLARGYL 309
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDATDE-IIKDG-------WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSG 491
Cdd:cd17649  310 GRPELTAErFVPDPfgapgsrLYRTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGA 389
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 492 SSGEAVKIFVVKKDPSLTED--ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd17649  390 GGKQLVAYVVLRAAAAQPELraQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
PRK08279 PRK08279
long-chain-acyl-CoA synthetase; Validated
17-553 5.66e-32

long-chain-acyl-CoA synthetase; Validated


Pssm-ID: 236217 [Multi-domain]  Cd Length: 600  Bit Score: 130.38  E-value: 5.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  17 INPDRYQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK08279  31 ITPDSKRSLGDVFEEAAARHPDRPALLFEDQSISYAELNARANRYAHWAAA-RGVGKGDVVALLMENRPEYLAAWLGLAK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLsTAKGTLVNFvvkyvkrlvp 176
Cdd:PRK08279 110 LGAVVALLNTQQRGAVLAHSLNLVDAKHLIVGEELVEAFEEARADLARPPRLWVAGGDTL-DDPEGYEDL---------- 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 177 KYHLPDAISFRRALHAGyrmqyvkpeIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqvnATYGPLLHPGKELVI-T 255
Cdd:PRK08279 179 AAAAAGAPTTNPASRSG---------VTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKAM----GGFGGLLRLTPDDVLyC 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 256 ALPLYHIFALT--MNCLLfieLGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG 333
Cdd:PRK08279 246 CLPLYHNTGGTvaWSSVL---AAGATLALRRKFSASRFWDDVRRYRATAFQYIGELCRYLLNQPPKPTDRDHRLRLMIGN 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 334 GM-PvqqAVAERWVKLTG-QYLLEGYGLTECaplvSVNPHDIDYHSGSIGLpVPSTEAK---LVD-DEDNE--------- 398
Cdd:PRK08279 323 GLrP---DIWDEFQQRFGiPRILEFYAASEG----NVGFINVFNFDGTVGR-VPLWLAHpyaIVKyDVDTGepvrdadgr 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 399 ---VPHGEPGELC--VRGPQVMLGYWQrPDATDE-IIKDG------WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVY 466
Cdd:PRK08279 395 cikVKPGEVGLLIgrITDRGPFDGYTD-PEASEKkILRDVfkkgdaWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVA 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 467 PNEIEDVVMQHSGVLEVAAVGVP-SGSSGEA--VKIfVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK08279 474 TTEVENALSGFPGVEEAVVYGVEvPGTDGRAgmAAI-VLADGAEFDLAALAAHLYERLPAYAVPLFVRLVPELETTGTFK 552
                        570
                 ....*....|
gi 489956626 544 ILRRELRDEA 553
Cdd:PRK08279 553 YRKVDLRKEG 562
PRK08308 PRK08308
acyl-CoA synthetase; Validated
181-549 7.71e-32

acyl-CoA synthetase; Validated


Pssm-ID: 236231 [Multi-domain]  Cd Length: 414  Bit Score: 127.46  E-value: 7.71e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 181 PDAISFRRALHAG-YRMQYVKPEIVSEDL--------AFLQYTGGTTGVAKgamlTHRNMLANLEQVNATYGPLLH-PGK 250
Cdd:PRK08308  67 PKEAAIRMAKRAGcHGLLYGESDFTKLEAvnylaeepSLLQYSSGTTGEPK----LIRRSWTEIDREIEAYNEALNcEQD 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 251 ELVITALPLYHIFALTMNCLLFIELGGQNVLIT--NPRDIpglVKELAKYPFTAMTGVNTLFNALlnnKEFQQLDFsTLH 328
Cdd:PRK08308 143 ETPIVACPVTHSYGLICGVLAALTRGSKPVIITnkNPKFA---LNILRNTPQHILYAVPLMLHIL---GRLLPGTF-QFH 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 --LSAGGGMPvqqavaERW---VKLTGQYLLEGYGLTEcAPLVSVNPHDIDyhSGSIGLPVPSTEAKLVDDEDNevphge 403
Cdd:PRK08308 216 avMTSGTPLP------EAWfykLRERTTYMMQQYGCSE-AGCVSICPDMKS--HLDLGNPLPHVSVSAGSDENA------ 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 404 PGELCVRgpqvmlgywqrpdatdeiIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEV 483
Cdd:PRK08308 281 PEEIVVK------------------MGDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEA 342
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626 484 AAVGVPSGSSGEAVKIFVVkKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK08308 343 VVYRGKDPVAGERVKAKVI-SHEEIDPVQLREWCIQHLAPYQVPHEIESVTEIPKNANGKVSRKLL 407
PRK12316 PRK12316
peptide synthase; Provisional
24-549 2.00e-31

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 130.46  E-value: 2.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   24 SLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK12316  512 GVHRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIE-RGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVP 590
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  104 VNPLYTPRELEHQLNDSGAAAIVivsnfahtlekvvekTQvkhvilTRMGDQLSTAKGtlvnfvvkyVKRLVpkyhLPDA 183
Cdd:PRK12316  591 LDPEYPAERLAYMLEDSGVQLLL---------------SQ------SHLGRKLPLAAG---------VQVLD----LDRP 636
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  184 ISFRralhAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGkelVITALPLYHIF 263
Cdd:PRK12316  637 AAWL----EGYSEENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGLGVGDT---VLQKTPFSFDV 709
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  264 ALTMnclLFIELGGQNVLITNPrdiPGLVKELAKYP-FTAMTGVNTL------FNALLNNKEFQQLDFSTLHLSAGGGMP 336
Cdd:PRK12316  710 SVWE---FFWPLMSGARLVVAA---PGDHRDPAKLVeLINREGVDTLhfvpsmLQAFLQDEDVASCTSLRRIVCSGEALP 783
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  337 ---VQQAVAERWVklTGQYLLegYGLTECAPLVSvnpHDIDYHSG----SIGLPVPSTEAKLVDDEDNEVPHGEPGELCV 409
Cdd:PRK12316  784 adaQEQVFAKLPQ--AGLYNL--YGPTEAAIDVT---HWTCVEEGgdsvPIGRPIANLACYILDANLEPVPVGVLGELYL 856
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  410 RGPQVMLGYWQRPDATDE-----IIKDG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLE 482
Cdd:PRK12316  857 AGRGLARGYHGRPGLTAErfvpsPFVAGerMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVRE 936
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626  483 VAAVGVpsgsSGEAVKIFVVKKDPS-LTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12316  937 AAVLAV----DGKQLVGYVVLESEGgDWREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDRKAL 1000
PTZ00216 PTZ00216
acyl-CoA synthetase; Provisional
49-455 3.51e-31

acyl-CoA synthetase; Provisional


Pssm-ID: 240316 [Multi-domain]  Cd Length: 700  Bit Score: 128.56  E-value: 3.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIV 128
Cdd:PTZ00216 122 ITYAELWERIVNFGRGLAE-LGLTKGSNVAIYEETRWEWLASIYGIWSQSMVAATVYANLGEDALAYALRETECKAIVCN 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 129 SNFAHTLEKVVEKTQVKHVILTRMGD---QLSTAKGTLVNF--VVkyvkrlvpkyhlpdAISFRRALHAGYRMQYVKpei 203
Cdd:PTZ00216 201 GKNVPNLLRLMKSGGMPNTTIIYLDSlpaSVDTEGCRLVAWtdVV--------------AKGHSAGSHHPLNIPENN--- 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 vsEDLAFLQYTGGTTGVAKGAMLTHRNMLANL----EQVNATYGPLlHPGkELVITALPLYHIFALT-MNCLLFielggQ 278
Cdd:PTZ00216 264 --DDLALIMYTSGTTGDPKGVMHTHGSLTAGIlaleDRLNDLIGPP-EED-ETYCSYLPLAHIMEFGvTNIFLA-----R 334
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 279 NVLIT--NPRDIPGLVK----ELAKYPFTAMTGVNTLFN------------------------------ALLNNKE---F 319
Cdd:PTZ00216 335 GALIGfgSPRTLTDTFArphgDLTEFRPVFLIGVPRIFDtikkaveaklppvgslkrrvfdhayqsrlrALKEGKDtpyW 414
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 320 QQLDFST--------LHLSAGGGMPVQQAVAErWVKLTGQYLLEGYGLTECaplVSVNPHDI--DYHSGSIGLPVPSTEA 389
Cdd:PTZ00216 415 NEKVFSApravlggrVRAMLSGGGPLSAATQE-FVNVVFGMVIQGWGLTET---VCCGGIQRtgDLEPNAVGQLLKGVEM 490
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 390 KLVDDEdnEVPHG---EP-GELCVRGPQVMLGYWQRPDATDEII-KDGWLHTGDIAVMDDEGFLRIVDRKK 455
Cdd:PTZ00216 491 KLLDTE--EYKHTdtpEPrGEILLRGPFLFKGYYKQEELTREVLdEDGWFHTGDVGSIAANGTLRIIGRVK 559
FACL_like_1 cd05910
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
49-553 1.04e-30

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341236 [Multi-domain]  Cd Length: 457  Bit Score: 124.88  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIViv 128
Cdd:cd05910    3 LSFRELDERSDRIAQGLTA-YGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQEAEPDAFI-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 129 snfahtlekvvektqvkhviltrmgdqlstakGtlvnfvvkyvkrlVPKYHLPDAISFrralhagyrmqyvkpeivsedl 208
Cdd:cd05910   80 --------------------------------G-------------IPKADEPAAILF---------------------- 92
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 209 aflqyTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllHPGkELVITALPLYHIFALTMNCLLFI-ELGGQNVLITNPRD 287
Cdd:cd05910   93 -----TSGSTGTPKGVVYRHGTFAAQIDALRQLYGI--RPG-EVDLATFPLFALFGPALGLTSVIpDMDPTRPARADPQK 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 288 ipgLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH--LSAGGgmPVQQAVAERWVKLT--GQYLLEGYGLTECA 363
Cdd:cd05910  165 ---LVGAIRQYGVSIVFGSPALLERVARYCAQHGITLPSLRrvLSAGA--PVPIALAARLRKMLsdEAEILTPYGATEAL 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 364 PLVSVNPHDI--------DYHSGS-IGLPVPSTEAKLV--DDED-------NEVPHGEPGELCVRGPQVMLGYWQRPDAT 425
Cdd:cd05910  240 PVSSIGSRELlatttaatSGGAGTcVGRPIPGVRVRIIeiDDEPiaewddtLELPRGEIGEITVTGPTVTPTYVNRPVAT 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 426 D-EIIKDG----WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVpsGSSGEAVKIF 500
Cdd:cd05910  320 AlAKIDDNsegfWHRMGDLGYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV--GKPGCQLPVL 397
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489956626 501 VVKKDPSLTED------ALITFCRRQLTGYKVPKLVeFRDELP---KSNvGKILRRELRDEA 553
Cdd:cd05910  398 CVEPLPGTITPrarleqELRALAKDYPHTQRIGRFL-IHPSFPvdiRHN-AKIFREKLAVWA 457
PRK12316 PRK12316
peptide synthase; Provisional
7-549 2.23e-30

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 127.38  E-value: 2.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626    7 NRYPADVPAEInpdryqSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQ 86
Cdd:PRK12316 1993 DRTPEAYPRGP------GVHQRIAEQAARAPEAIAVVFGDQHLSYAELDSRANRLAHRLRA-RGVGPEVRVAIAAERSFE 2065
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   87 YPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVEKTQVKHVILTRMGDQlstakgtlvn 165
Cdd:PRK12316 2066 LVVALLAVLKAGGAYVPLDPNY-PAErLAYMLEDSGAALLLTQR---HLLERLPLPAGVARLPLDRDAEW---------- 2131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  166 fvvkyvkrlvpkyhlpdaisfrralhAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpl 245
Cdd:PRK12316 2132 --------------------------ADYPDTAPAVQLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYE-- 2183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  246 LHPGK-ELVITALPlyhiFALTMNCLLFIELGGQNVLITNP--RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQ-- 320
Cdd:PRK12316 2184 LSPADcELQFMSFS----FDGAHEQWFHPLLNGARVLIRDDelWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAERDgr 2259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  321 QLDFSTLHLsagGGMPVQQAVAER-WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTEAKLVDDE 395
Cdd:PRK12316 2260 PPAVRVYCF---GGEAVPAASLRLaWEALRPVYLFNGYGPTEAVVTPLLWKCRPQDPCGAayvpIGRALGNRRAYILDAD 2336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  396 DNEVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKDGWLH-------TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYP 467
Cdd:PRK12316 2337 LNLLAPGMAGELYLGGEGLARGYLNRPGLTAErFVPDPFSAsgerlyrTGDLARYRADGVVEYLGRIDHQVKIRGFRIEL 2416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  468 NEIEDVVMQHSGVLEvAAVGVPSGSSGEAVKIFVVKKDP-SLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:PRK12316 2417 GEIEARLQAHPAVRE-AVVVAQDGASGKQLVAYVVPDDAaEDLLAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDR 2495

                  ...
gi 489956626  547 REL 549
Cdd:PRK12316 2496 KAL 2498
PRK07768 PRK07768
long-chain-fatty-acid--CoA ligase; Validated
201-548 2.90e-30

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236091 [Multi-domain]  Cd Length: 545  Bit Score: 124.72  E-value: 2.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 201 PEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITALPLYH------IFALTMNCllfie 274
Cdd:PRK07768 147 VETGEDDLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAE--FDVETDVMVSWLPLFHdmgmvgFLTVPMYF----- 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 275 lGGQNVLITnPRDI---PGLVKEL-AKYPFTAMTGVN---TLFNALLNNK-EFQQLDFSTLHLSAGGGMPVQQAVAERWV 346
Cdd:PRK07768 220 -GAELVKVT-PMDFlrdPLLWAELiSKYRGTMTAAPNfayALLARRLRRQaKPGAFDLSSLRFALNGAEPIDPADVEDLL 297
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 347 ------KLTGQYLLEGYGLTECAPLVSVNPHD----IDY---------------HSG------SIGLPVPSTEAKLVDDE 395
Cdd:PRK07768 298 dagarfGLRPEAILPAYGMAEATLAVSFSPCGaglvVDEvdadllaalrravpaTKGntrrlaTLGPPLPGLEVRVVDED 377
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 396 DNEVPHGEPGELCVRGPQVMLGYwQRPD----ATDEiikDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIE 471
Cdd:PRK07768 378 GQVLPPRGVGVIELRGESVTPGY-LTMDgfipAQDA---DGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIE 453
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 472 DVVMQHSGVLE--VAAVGVPSGSSGEAVKIFVVKKDPSltEDALITFCRRQLTgYKVPKLVEFRDE---------LPKSN 540
Cdd:PRK07768 454 RAAARVEGVRPgnAVAVRLDAGHSREGFAVAVESNAFE--DPAEVRRIRHQVA-HEVVAEVGVRPRnvvvlgpgsIPKTP 530

                 ....*...
gi 489956626 541 VGKiLRRE 548
Cdd:PRK07768 531 SGK-LRRA 537
PRK12467 PRK12467
peptide synthase; Provisional
5-549 2.97e-30

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 126.81  E-value: 2.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626    5 WlNRYPADVPAEinpdryQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNL 84
Cdd:PRK12467 1563 W-NATHTGYPLA------RLVHQLIEDQAAATPEAVALVFGEQELTYGELNRRANRLAHRLIA-LGVGPEVLVGIAVERS 1634
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVEKTQVKHVILTRMGDQLstakgtlv 164
Cdd:PRK12467 1635 LEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQS---HLQARLPLPDGLRSLVLDQEDDWL-------- 1703
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  165 nfvvkyvkrlvpkyhlpdaisfrralhAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGp 244
Cdd:PRK12467 1704 ---------------------------EGYSDSNPAVNLAPQNLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEAYQ- 1755
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  245 lLHPGKelvitALPLYHIFALTMNC--LLFIELGGQNVLITNP---RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEF 319
Cdd:PRK12467 1756 -LSAAD-----VVLQFTSFAFDVSVweLFWPLINGARLVIAPPgahRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQ 1829
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  320 QQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTEAKLVDDE 395
Cdd:PRK12467 1830 VEHPLSLRRVVCGGEALEVEALRPWLERLPDTGLFNLYGPTETAVDVTHWTCRRKDLEGRdsvpIGQPIANLSTYILDAS 1909
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  396 DNEVPHGEPGELCVRGPQVMLGYWQRPDATDEII-------KDGWLH-TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYP 467
Cdd:PRK12467 1910 LNPVPIGVAGELYLGGVGLARGYLNRPALTAERFvadpfgtVGSRLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRIEL 1989
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  468 NEIEDVVMQHSGVLEvAAVGVPSGSSGEAVKIFVVKKDPSLTEDAL-ITFCRRQLTG--------YKVPKLVEFRDELPK 538
Cdd:PRK12467 1990 GEIEARLREQGGVRE-AVVIAQDGANGKQLVAYVVPTDPGLVDDDEaQVALRAILKNhlkaslpeYMVPAHLVFLARMPL 2068
                         570
                  ....*....|.
gi 489956626  539 SNVGKILRREL 549
Cdd:PRK12467 2069 TPNGKLDRKAL 2079
PRK05857 PRK05857
fatty acid--CoA ligase;
200-549 4.59e-30

fatty acid--CoA ligase;


Pssm-ID: 180293 [Multi-domain]  Cd Length: 540  Bit Score: 123.97  E-value: 4.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 200 KPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLA--------NLEQVNATYGpllhpgkELVITALPLYHIFAL--TMNC 269
Cdd:PRK05857 163 NADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAvpdilqkeGLNWVTWVVG-------ETTYSPLPATHIGGLwwILTC 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 270 LLFielGGqnVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmpvQQAVAE--RWVK 347
Cdd:PRK05857 236 LMH---GG--LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGG---SRAIAAdvRFIE 307
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 348 LTGQYLLEGYGLTE------CAPLVSVNPHDIDyhSGSIGLPVPSTEAKLVDDE--DNEVPHGEP----GELCVRGPQVM 415
Cdd:PRK05857 308 ATGVRTAQVYGLSEtgctalCLPTDDGSIVKIE--AGAVGRPYPGVDVYLAATDgiGPTAPGAGPsasfGTLWIKSPANM 385
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 416 LGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGE 495
Cdd:PRK05857 386 LGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGA 465
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 496 AVKIFVVKKdPSLTEDALITFCRRQLTGYK-------VPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05857 466 LVGLAVVAS-AELDESAARALKHTIAARFRresepmaRPSTIVIVTDIPRTQSGKVMRASL 525
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
23-549 4.77e-30

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 125.93  E-value: 4.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK10252  458 TTLSALVAQQAAKTPDAPALADARYQFSYREMREQVVALANLLRE-RGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWL 536
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLekvvektqvkhviltrMGDQLSTakgtlvnfvvkyvkrlVPKYHLPD 182
Cdd:PRK10252  537 PLDTGYPDDRLKMMLEDARPSLLITTADQLPRF----------------ADVPDLT----------------SLCYNAPL 584
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  183 AISFRRALHAGyrmqyvKPEivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYG------------------- 243
Cdd:PRK10252  585 APQGAAPLQLS------QPH----HTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPltaddvvlqktpcsfdvsv 654
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  244 -----PLLhPGKELVItALPLYHifaltmncllfielggqnvlitnpRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKE 318
Cdd:PRK10252  655 weffwPFI-AGAKLVM-AEPEAH------------------------RDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLT 708
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  319 FQQLDFSTLHLS----AGGGMPVQQAvaERWVKLTGQYLLEGYGLTECAPLVSVNP---HDIDYHSGS---IGLPVPSTE 388
Cdd:PRK10252  709 PEGARQSCASLRqvfcSGEALPADLC--REWQQLTGAPLHNLYGPTEAAVDVSWYPafgEELAAVRGSsvpIGYPVWNTG 786
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  389 AKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKDGWL------HTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:PRK10252  787 LRILDARMRPVPPGVAGDLYLTGIQLAQGYLGRPDLTASrFIADPFApgermyRTGDVARWLDDGAVEYLGRSDDQLKIR 866
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  462 GFNVYPNEIEDVVMQHSGVLEVAAVGV-------PSGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRD 534
Cdd:PRK10252  867 GQRIELGEIDRAMQALPDVEQAVTHACvinqaaaTGGDARQLVGYLVSQSGLPLDTSALQAQLRERLPPHMVPVVLLQLD 946
                         570
                  ....*....|....*
gi 489956626  535 ELPKSNVGKILRREL 549
Cdd:PRK10252  947 QLPLSANGKLDRKAL 961
PRK07867 PRK07867
acyl-CoA synthetase; Validated
38-553 1.61e-29

acyl-CoA synthetase; Validated


Pssm-ID: 236120 [Multi-domain]  Cd Length: 529  Bit Score: 122.48  E-value: 1.61e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK07867  18 DDRGLYFEDSFTSWREHIRGSAARAAALRARLDPTRPPHVGVLLDNTPEFSLLLGAAALSGIVPVGLNPTRRGAALARDI 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAKGTLVNFVVkyvkrlvpkyhlPDAisfrralhagyrmq 197
Cdd:PRK07867  98 AHADCQLVLTESAHAELLDGLDPGVRVINVDSPAWADELAAHRDAEPPFRV------------ADP-------------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yvkpeivsEDLAFLQYTGGTTGVAKGAMLTHR------NMLAnleqvnATYGplLHPGkELVITALPLYHIFALtMNCLL 271
Cdd:PRK07867 152 --------DDLFMLIFTSGTSGDPKAVRCTHRkvasagVMLA------QRFG--LGPD-DVCYVSMPLFHSNAV-MAGWA 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 272 FIELGGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG--GGMPVQQAVAERWvklt 349
Cdd:PRK07867 214 VALAAGASIALRRKFSASGFLPDVRRYGATYANYVGKPLSYVLATPERPDDADNPLRIVYGneGAPGDIARFARRF---- 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 350 GQYLLEGYGLTECAPLVSVNPhdiDYHSGSIGLPVPSTeaKLVD-DEDNEVPHGEP------------GELC-VRGPQVM 415
Cdd:PRK07867 290 GCVVVDGFGSTEGGVAITRTP---DTPPGALGPLPPGV--AIVDpDTGTECPPAEDadgrllnadeaiGELVnTAGPGGF 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 416 LGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGE 495
Cdd:PRK07867 365 EGYYNDPEADAERMRGGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGD 444
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 496 AVKIFVV-KKDPSLTEDALITFCRRQ--LTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK07867 445 QVMAALVlAPGAKFDPDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQLSAEG 505
MACS_like_1 cd05974
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
49-550 4.87e-29

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341278 [Multi-domain]  Cd Length: 432  Bit Score: 119.59  E-value: 4.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLnDSGAAAIVIV 128
Cdd:cd05974    1 VSFAEMSARSSRVANFLRS-IGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLRDRV-DRGGAVYAAV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 129 SNFAHtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivSEDL 208
Cdd:cd05974   79 DENTH-----------------------------------------------------------------------ADDP 87
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 209 AFLQYTGGTTGVAKGAMLTHRNMLANleQVNATYGPLLHPGKELVITALPLYHIFALTmnCLLFIELGGQNVLITN-PR- 286
Cdd:cd05974   88 MLLYFTSGTTSKPKLVEHTHRSYPVG--HLSTMYWIGLKPGDVHWNISSPGWAKHAWS--CFFAPWNAGATVFLFNyARf 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 DIPGLVKELAKYPFTAMTGVNTLFNALLnnkefqQLDFSTLHLS----AGGGMPVQQAVAERWVKLTGQYLLEGYGLTEC 362
Cdd:cd05974  164 DAKRVLAALVRYGVTTLCAPPTVWRMLI------QQDLASFDVKlrevVGAGEPLNPEVIEQVRRAWGLTIRDGYGQTET 237
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 363 APLVSVNPHDIdYHSGSIGLPVPSTEAKLVDDEDNEVphgEPGELCV-----RGPQVMLGYWQRPDATDEIIKDGWLHTG 437
Cdd:cd05974  238 TALVGNSPGQP-VKAGSMGRPLPGYRVALLDPDGAPA---TEGEVALdlgdtRPVGLMKGYAGDPDKTAHAMRGGYYRTG 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 438 DIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-----KKDPSLTEDa 512
Cdd:cd05974  314 DIAMRDEDGYLTYVGRADDVFKSSDYRISPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVlragyEPSPETALE- 392
                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 489956626 513 LITFCRRQLTGYKVPKLVEFRdELPKSNVGKILRRELR 550
Cdd:cd05974  393 IFRFSRERLAPYKRIRRLEFA-ELPKTISGKIRRVELR 429
A_NRPS_ApnA-like cd17644
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...
27-549 1.83e-28

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341299 [Multi-domain]  Cd Length: 465  Bit Score: 118.31  E-value: 1.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  27 ELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17644    4 QLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQS-LGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLDP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 107 LYtPRElehqlndsgaaaivivsnfahTLEKVVEKTQVKhVILTRmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisf 186
Cdd:cd17644   83 NY-PQE---------------------RLTYILEDAQIS-VLLTQ----------------------------------- 104
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 187 rralhagyrmqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMlanleqVNATYGPLlhpgKELVITAlplyhifalT 266
Cdd:cd17644  105 ------------------PENLAYVIYTSGSTGKPKGVMIEHQSL------VNLSHGLI----KEYGITS---------S 147
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 267 MNCLLFIEL---------------GGQNVLITNP--RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF-STLH 328
Cdd:cd17644  148 DRVLQFASIafdvaaeeiyvtllsGATLVLRPEEmrSSLEDFVQYIQQWQLTVLSLPPAYWHLLVLELLLSTIDLpSSLR 227
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 LSAGGGMPVQQAVAERWVKLTGQY--LLEGYGLTECAPLVSV----NPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHG 402
Cdd:cd17644  228 LVIVGGEAVQPELVRQWQKNVGNFiqLINVYGPTEATIAATVcrltQLTERNITSVPIGRPIANTQVYILDENLQPVPVG 307
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 403 EPGELCVRGPQVMLGYWQRPDATDE-IIKDGWLH--------TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:cd17644  308 VPGELHIGGVGLARGYLNRPELTAEkFISHPFNSseserlykTGDLARYLPDGNIEYLGRIDNQVKIRGFRIELGEIEAV 387
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 474 VMQHSGVlEVAAVGVPSGSSGEA--VKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17644  388 LSQHNDV-KTAVVIVREDQPGNKrlVAYIVPHYEESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKIDRRAL 464
PRK12467 PRK12467
peptide synthase; Provisional
7-551 2.35e-28

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 121.04  E-value: 2.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626    7 NRYPADVPAEinpdryQSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFA-AYLQEGLGlqkGDR-VALMMPNL 84
Cdd:PRK12467 3085 NATAAAYPSE------RLVHQLIEAQVARTPEAPALVFGDQQLSYAELNRRANRLAhRLIAIGVG---PDVlVGVAVERS 3155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   85 LQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVivsnfahTLEKVVEKTQVKHVILTRMGDQLSTAkgtl 163
Cdd:PRK12467 3156 VEMIVALLAVLKAGGAYVPLDPEY-PRErLAYMIEDSGVKLLL-------TQAHLLEQLPAPAGDTALTLDRLDLN---- 3223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  164 vnfvvkyvkrlvpkyhlpdaisfrralhaGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHrNMLANLEQVNATYG 243
Cdd:PRK12467 3224 -----------------------------GYSENNPSTRVMGENLAYVIYTSGSTGKPKGVGVRH-GALANHLCWIAEAY 3273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  244 PLLHPGKELVITALPlyhiFALTMNCLLFIEL-GGQNVLITNP-RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:PRK12467 3274 ELDANDRVLLFMSFS----FDGAQERFLWTLIcGGCLVVRDNDlWDPEELWQAIHAHRISIACFPPAYLQQFAEDAGGAD 3349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  322 LDFSTLHLSAGGGMPVQqAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTEAKLVDDEDN 397
Cdd:PRK12467 3350 CASLDIYVFGGEAVPPA-AFEQVKRKLKPRGLTNGYGPTEAVVTVTLWKCGGDAVCEApyapIGRPVAGRSIYVLDGQLN 3428
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  398 EVPHGEPGELCVRGPQVMLGYWQRPDATDE-IIKD------GWLH-TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PRK12467 3429 PVPVGVAGELYIGGVGLARGYHQRPSLTAErFVADpfsgsgGRLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 3508
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  470 IEDVVMQHSGVLEVAAVGVPsGSSGEAVKIFVVKKDPSLT-EDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:PRK12467 3509 IEARLLQHPSVREAVVLARD-GAGGKQLVAYVVPADPQGDwRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKA 3587

                  ...
gi 489956626  549 LRD 551
Cdd:PRK12467 3588 LPD 3590
ttLC_FACS_like cd05915
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
50-550 6.58e-28

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.


Pssm-ID: 213283 [Multi-domain]  Cd Length: 509  Bit Score: 117.53  E-value: 6.58e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd05915   26 TYAEVYQRARRLMGGLRA-LGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVLLFDP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 NFAHTLEKVVEktqvkhvILTRMGDQLSTAKgtlvnfvvkyvkrlvpKYHlpdaiSFRRALHAGY-RMQYVKPEIVSEDL 208
Cdd:cd05915  105 NLLPLVEAIRG-------ELKTVQHFVVMDE----------------KAP-----EGYLAYEEALgEEADPVRVPERAAC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 209 AfLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPgKELVITALPLYHIFALtmnCLLFI--ELGGQNVLITNPR 286
Cdd:cd05915  157 G-MAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSE-KDVVLPVVPMFHVNAW---CLPYAatLVGAKQVLPGPRL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 287 DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS-TLHLSAGGGMPVQqaVAERWVKLTGQYLLEGYGLTEC--- 362
Cdd:cd05915  232 DPASLVELFDGEGVTFTAGVPTVWLALADYLESTGHRLKtLRRLVVGGSAAPR--SLIARFERMGVEVRQGYGLTETspv 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 363 ------APLVSVNPHDIDYH-SGSIGLPVPSTEAKLVDDEDNEVPHGEPG--ELCVRGPQVMLGYWQRPDATDEI-IKDG 432
Cdd:cd05915  310 vvqnfvKSHLESLSEEEKLTlKAKTGLPIPLVRLRVADEEGRPVPKDGKAlgEVQLKGPWITGGYYGNEEATRSAlTPDG 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 433 WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDA 512
Cdd:cd05915  390 FFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEE 469
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 489956626 513 LITFCRRQLTGYK-VPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05915  470 LNEHLLKAGFAKWqLPDAYVFAEEIPRTSAGKFLKRALR 508
A_NRPS_PpsD_like cd17650
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...
38-549 1.11e-27

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341305 [Multi-domain]  Cd Length: 447  Bit Score: 116.03  E-value: 1.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17650    2 DAIAVSDATRQLTYRELNERANQLARTLRG-LGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhLPdaisfrralhagyrmq 197
Cdd:cd17650   81 EDSGAKLLLT----------------------------------------------------QP---------------- 92
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVITALPLYHIFALTMNCLLFielGG 277
Cdd:cd17650   93 --------EDLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDSFPVRLLQMASFSFDVFAGDFARSLLN---GG 161
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 278 QNVLITNPR--DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG--GMPVQQAVAERWVKLTGQYL 353
Cdd:cd17650  162 TLVICPDEVklDPAALYDLILKSRITLMESTPALIRPVMAYVYRNGLDLSAMRLLIVGsdGCKAQDFKTLAARFGQGMRI 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 354 LEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEII 429
Cdd:cd17650  242 INSYGVTEATIDSTYYEEGRDPLGDSanvpIGRPLPNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERF 321
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 430 KDGWL-------HTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEvAAVGVPSGSSGEAVKIFVV 502
Cdd:cd17650  322 VENPFapgermyRTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDE-AVVAVREDKGGEARLCAYV 400
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 489956626 503 KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17650  401 VAAATLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447
PRK07824 PRK07824
o-succinylbenzoate--CoA ligase;
175-550 1.36e-27

o-succinylbenzoate--CoA ligase;


Pssm-ID: 236108 [Multi-domain]  Cd Length: 358  Bit Score: 113.99  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 175 VPKYHLPDAISFRRALHAGyrmqyvkpEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvnATYGPLLHPGKELVi 254
Cdd:PRK07824  12 VPAQDERRAALLRDALRVG--------EPIDDDVALVVATSGTTGTPKGAMLTAAALTASAD---ATHDRLGGPGQWLL- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 255 tALPLYHIFAltMNCLLFIELGGQNVLIT------NPRDIPGLVKELA---KYpfTAMTGVNtLFNALLNNKEFQQLDFS 325
Cdd:PRK07824  80 -ALPAHHIAG--LQVLVRSVIAGSEPVELdvsagfDPTALPRAVAELGggrRY--TSLVPMQ-LAKALDDPAATAALAEL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 326 TLHLSAGGGMPVQqaVAERWVKLtGQYLLEGYGLTECAplvsvnphdidyhSGSI--GLPVPSTEAKLVDdednevphge 403
Cdd:PRK07824 154 DAVLVGGGPAPAP--VLDAAAAA-GINVVRTYGMSETS-------------GGCVydGVPLDGVRVRVED---------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 404 pGELCVRGPQVMLGYwQRPDATDEIIKDGWLHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEV 483
Cdd:PRK07824 208 -GRIALGGPTLAKGY-RNPVDPDPFAEPGWFRTDDLGALDD-GVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADC 284
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 484 AAVGVPSGSSGEAVKIFVVKK-DPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07824 285 AVFGLPDDRLGQRVVAAVVGDgGPAPTLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRALV 352
FATP_FACS cd05940
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...
46-553 2.92e-27

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341263 [Multi-domain]  Cd Length: 449  Bit Score: 114.76  E-value: 2.92e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05940    1 DEALTYAELDAMANRYARWLK-SLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIvsnfahtlekvvektqvkhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmqyvkpeivs 205
Cdd:cd05940   80 VV------------------------------------------------------------------------------ 81
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 eDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVnatYGPLLHPGKELVITALPLYHIFALTMnCLLFIELGGQNVLITNP 285
Cdd:cd05940   82 -DAALYIYTSGTTGLPKAAIISHRRAWRGGAFF---AGSGGALPSDVLYTCLPLYHSTALIV-GWSACLASGATLVIRKK 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 286 RDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqqavAERWVKLTGQY----LLEGYGLTE 361
Cdd:cd05940  157 FSASNFWDDIRKYQATIFQYIGELCRYLLNQPPKPTERKHKVRMIFGNGLR-----PDIWEEFKERFgvprIAEFYAATE 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 362 CApLVSVNphdIDYHSGSIG----LPVPSTEAKLVD-DEDN------------EVPHGEPGELCVR--GPQVMLGYWQrP 422
Cdd:cd05940  232 GN-SGFIN---FFGKPGAIGrnpsLLRKVAPLALVKyDLESgepirdaegrciKVPRGEPGLLISRinPLEPFDGYTD-P 306
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 423 DATDEIIK-------DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVP-SGSSG 494
Cdd:cd05940  307 AATEKKILrdvfkkgDAWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQvPGTDG 386
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 495 EA-VKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05940  387 RAgMAAIVLQPNEEFDLSALAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLRNEG 446
hsFATP4_like cd05939
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...
46-553 2.78e-26

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341262 [Multi-domain]  Cd Length: 474  Bit Score: 112.13  E-value: 2.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQeGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05939    1 DRHWTFRELNEYSNKVANFFQ-AQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VivsnfahtlekvvektqvkhvilTRMGDQLSTAKGTlvnfvvkyvkrlvpkyHLP--DAISFRRALhagyrmqyvkpei 203
Cdd:cd05939   80 I-----------------------FNLLDPLLTQSST----------------EPPsqDDVNFRDKL------------- 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 vsedlaFLQYTGGTTGVAKGAMLTHRNMLanLEQVNATYGPLLHPgKELVITALPLYHIFALTM---NCLLFielgGQNV 280
Cdd:cd05939  108 ------FYIYTSGTTGLPKAAVIVHSRYY--RIAAGAYYAFGMRP-EDVVYDCLPLYHSAGGIMgvgQALLH----GSTV 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 281 LITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqqavAERWVKLTGQY----LLEG 356
Cdd:cd05939  175 VIRKKFSASNFWDDCVKYNCTIVQYIGEICRYLLAQPPSEEEQKHNVRLAVGNGLR-----PQIWEQFVRRFgipqIGEF 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 357 YGLTECaplvSVNPHDIDYHSGSIGLpVPSTEAKL-------VDDEDNE------------VPhGEPGELCVRGPQ---- 413
Cdd:cd05939  250 YGATEG----NSSLVNIDNHVGACGF-NSRILPSVypirlikVDEDTGElirdsdglcipcQP-GEPGLLVGKIIQndpl 323
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 414 -VMLGYWQRPDATDEIIKDGWLH------TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAV 486
Cdd:cd05939  324 rRFDGYVNEGATNKKIARDVFKKgdsaflSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVY 403
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 487 GVP-SGSSGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05939  404 GVEvPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQKEG 471
PRK13383 PRK13383
acyl-CoA synthetase; Provisional
35-549 4.54e-26

acyl-CoA synthetase; Provisional


Pssm-ID: 139531 [Multi-domain]  Cd Length: 516  Bit Score: 112.01  E-value: 4.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTprele 114
Cdd:PRK13383  47 RWPGRTAIIDDDGALSYRELQRATESLARRLTRD-GVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFR----- 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 115 hqlNDSGAAAIVivsnfAHTLEKVVEKTQvkhviltrMGDQLSTAKgtlvnfvvkyvkrlvpkyhlpDAISFRRALHAGY 194
Cdd:PRK13383 121 ---SDALAAALR-----AHHISTVVADNE--------FAERIAGAD---------------------DAVAVIDPATAGA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 195 RMQYVKPEIVSEDLAFLqYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPLLHPGKELVItALPLYHIFALTMnCLLFIE 274
Cdd:PRK13383 164 EESGGRPAVAAPGRIVL-LTSGTTGKPKGVPRAPQLRSAVGVWVTILDRTRLRTGSRISV-AMPMFHGLGLGM-LMLTIA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 275 LGGqNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQY 352
Cdd:PRK13383 241 LGG-TVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILElpPRVRARNPLPQLRVVMSSGDRLDPTLGQRFMDTYGDI 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 LLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYwqrPDATDEIIKDG 432
Cdd:PRK13383 320 LYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRY---TDGGGKAVVDG 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 433 WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPS-LTED 511
Cdd:PRK13383 397 MTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSgVDAA 476
                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 489956626 512 ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK13383 477 QLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKEL 514
PLN02387 PLN02387
long-chain-fatty-acid-CoA ligase family protein
2-458 2.41e-25

long-chain-fatty-acid-CoA ligase family protein


Pssm-ID: 215217 [Multi-domain]  Cd Length: 696  Bit Score: 110.59  E-value: 2.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   2 KKVWLNRYPADVPAE----INPDRYQSLIE-----------LFEHSVRRYADQP----------AFVNMGEVMTFRKLE- 55
Cdd:PLN02387  22 KKGKKRGVPVDVGGEpgyaIRNARFPELVEtpwegattlaaLFEQSCKKYSDKRllgtrklisrEFETSSDGRKFEKLHl 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  56 ------------ERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAA 123
Cdd:PLN02387 102 geyewitygqvfERVCNFASGLVA-LGHNKEERVAIFADTRAEWLIALQGCFRQNITVVTIYASLGEEALCHSLNETEVT 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 124 AIVIVSNFAHTLEKVVEK-TQVKHVI-LTRMGDQLSTAKGTLVNFVVkyvkrlvpkyhlpdaISFRRALHAGyRMQYVKP 201
Cdd:PLN02387 181 TVICDSKQLKKLIDISSQlETVKRVIyMDDEGVDSDSSLSGSSNWTV---------------SSFSEVEKLG-KENPVDP 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 202 EI-VSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVnATYGPLLHPgKELVITALPLYHIFALTMNCLLF-----IEL 275
Cdd:PLN02387 245 DLpSPNDIAVIMYTSGSTGLPKGVMMTHGNIVATVAGV-MTVVPKLGK-NDVYLAYLPLAHILELAAESVMAavgaaIGY 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 276 GGQNVLITNPRDIP----GLVKELAKypfTAMTGV----------------------NTLFN-------ALLNNKEF--- 319
Cdd:PLN02387 323 GSPLTLTDTSNKIKkgtkGDASALKP---TLMTAVpaildrvrdgvrkkvdakgglaKKLFDiaykrrlAAIEGSWFgaw 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 320 -------QQLDFSTLHLSAG--------GGMPVQqAVAERWVKLT-GQYLLEGYGLTE-CAPLVSVNPHDIDYhsGSIGL 382
Cdd:PLN02387 400 glekllwDALVFKKIRAVLGgrirfmlsGGAPLS-GDTQRFINIClGAPIGQGYGLTEtCAGATFSEWDDTSV--GRVGP 476
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 383 PVPSTEAKLVDDE-------DNEVPHGEpgeLCVRGPQVMLGYWQRPDATDEIIKDG-----WLHTGDIAVMDDEGFLRI 450
Cdd:PLN02387 477 PLPCCYVKLVSWEeggylisDKPMPRGE---IVIGGPSVTLGYFKNQEKTDEVYKVDergmrWFYTGDIGQFHPDGCLEI 553

                 ....*...
gi 489956626 451 VDRKKDMI 458
Cdd:PLN02387 554 IDRKKDIV 561
PRK12316 PRK12316
peptide synthase; Provisional
7-549 3.22e-25

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 111.20  E-value: 3.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626    7 NRYPADVPAEINPDRyqslieLFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQ 86
Cdd:PRK12316 3047 NATAAEYPLERGVHR------LFEEQVERTPDAVALAFGEQRLSYAELNRRANRLAHRLIE-RGVGPDVLVGVAVERSLE 3119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   87 YPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAaaivivsnfahtlekvvektqvkHVILTRMGDQLSTAKGtlvnf 166
Cdd:PRK12316 3120 MVVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSGA-----------------------QLLLSQSHLRLPLAQG----- 3171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  167 vvkyVKRLVPKYHLPDAISFRRALHagyrmqyvkpeIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplL 246
Cdd:PRK12316 3172 ----VQVLDLDRGDENYAEANPAIR-----------TMPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYG--L 3234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  247 HPGKELVITALPLYHIFALTMNCLLfieLGGQNVLITNPR---DIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLD 323
Cdd:PRK12316 3235 GVGDRVLQFTTFSFDVFVEELFWPL---MSGARVVLAGPEdwrDPALLVELINSEGVDVLHAYPSMLQAFLEEEDAHRCT 3311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  324 FSTLHLSAGGGMPVQqaVAERWVklTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS-IGLPVPSTEAKLVDDEDNEVPHG 402
Cdd:PRK12316 3312 SLKRIVCGGEALPAD--LQQQVF--AGLPLYNLYGPTEATITVTHWQCVEEGKDAVpIGRPIANRACYILDGSLEPVPVG 3387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  403 EPGELCVRGPQVMLGYWQRPDATDE-------IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK12316 3388 ALGELYLGGEGLARGYHNRPGLTAErfvpdpfVPGERLYRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLL 3467
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489956626  476 QHSGVLEVAAVGVpsgsSGEAVKIFVVKKDPSLT-EDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12316 3468 EHPWVREAVVLAV----DGRQLVAYVVPEDEAGDlREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKAL 3538
PLN02614 PLN02614
long-chain acyl-CoA synthetase
190-476 1.48e-24

long-chain acyl-CoA synthetase


Pssm-ID: 166255 [Multi-domain]  Cd Length: 666  Bit Score: 108.18  E-value: 1.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 190 LHAGYRMQYVKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLA-------NLEQVNATYGPllhpgKELVITALPLYHI 262
Cdd:PLN02614 207 LKLGEGKQYDLPIKKKSDICTIMYTSGTTGDPKGVMISNESIVTliagvirLLKSANAALTV-----KDVYLSYLPLAHI 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 263 FALTMN-CllFIELGGQ--------NVLITN------------PRDI----PGLVKELA--------------KYPFTAM 303
Cdd:PLN02614 282 FDRVIEeC--FIQHGAAigfwrgdvKLLIEDlgelkptifcavPRVLdrvySGLQKKLSdggflkkfvfdsafSYKFGNM 359
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 304 ------TGVNTLFNALLNNKEFQQLDfSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYh 376
Cdd:PLN02614 360 kkgqshVEASPLCDKLVFNKVKQGLG-GNVRIILSGAAPLASHVESFLRVVACCHVLQGYGLTEsCAGTFVSLPDELDM- 437
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 377 SGSIGLPVPSTEAKL--VDDEDNEVPHGEP-GELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDR 453
Cdd:PLN02614 438 LGTVGPPVPNVDIRLesVPEMEYDALASTPrGEICIRGKTLFSGYYKREDLTKEVLIDGWLHTGDVGEWQPNGSMKIIDR 517
                        330       340
                 ....*....|....*....|....
gi 489956626 454 KKDMI-LVSGFNVYPNEIEDVVMQ 476
Cdd:PLN02614 518 KKNIFkLSQGEYVAVENIENIYGE 541
PRK12582 PRK12582
acyl-CoA synthetase; Provisional
69-452 1.63e-24

acyl-CoA synthetase; Provisional


Pssm-ID: 237144 [Multi-domain]  Cd Length: 624  Bit Score: 107.82  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  69 LGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH----QLNDSGAAAIVIVSN---FAHTLEkVVEK 141
Cdd:PRK12582 100 LGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYSLMSHDHaklkHLFDLVKPRVVFAQSgapFARALA-ALDL 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 142 TQVKHVILTRMGD-QLSTAKGTLVNFVVKyvkrlvpkyhlpDAIsfrRALHAGyrmqyVKPEIVSEDLaflqYTGGTTGV 220
Cdd:PRK12582 179 LDVTVVHVTGPGEgIASIAFADLAATPPT------------AAV---AAAIAA-----ITPDTVAKYL----FTSGSTGM 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 221 AKGAMLTHRNMLANLEQVNATYGPLLHPGKELVITALPLYHIFA--LTMNCLLFielGGQNVLITNPRDIPGLVKELAK- 297
Cdd:PRK12582 235 PKAVINTQRMMCANIAMQEQLRPREPDPPPPVSLDWMPWNHTMGgnANFNGLLW---GGGTLYIDDGKPLPGMFEETIRn 311
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 298 -------YPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERW----VKLTGQY--LLEGYGLTECAP 364
Cdd:PRK12582 312 lreisptVYGNVPAGYAMLAEAMEKDDALRRSFFKNLRLMAYGGATLSDDLYERMqalaVRTTGHRipFYTGYGATETAP 391
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 365 lVSVNPHDIDYHSGSIGLPVPSTEAKLvddedneVPHGEPGELCVRGPQVMLGYWQRPDATDeiikdgwlhtgdiAVMDD 444
Cdd:PRK12582 392 -TTTGTHWDTERVGLIGLPLPGVELKL-------APVGDKYEVRVKGPNVTPGYHKDPELTA-------------AAFDE 450

                 ....*...
gi 489956626 445 EGFLRIVD 452
Cdd:PRK12582 451 EGFYRLGD 458
PRK05691 PRK05691
peptide synthase; Validated
23-549 2.60e-24

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 108.33  E-value: 2.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK05691 1131 AWLPELLNEQARQTPERIALVWDGGSLDYAELHAQANRLAHYLRD-KGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYV 1209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  103 NVNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVEKTQVKHVILtrmgDQLStakgtLVNFVVKyvkrlVPKYHLPD 182
Cdd:PRK05691 1210 PLDPDYPAERLAYMLADSGVELLLTQS---HLLERLPQAEGVSAIAL----DSLH-----LDSWPSQ-----APGLHLHG 1272
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  183 aisfrralhagyrmqyvkpeivsEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITA-----L 257
Cdd:PRK05691 1273 -----------------------DNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYA--LDDSDVLMQKApisfdV 1327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  258 PLYHIF-ALTMNCLLFIELGGQNvliTNPRDIPGLVKElakYPFTAMTGVNTLFNALLNnkEFQQLDFSTLHLSAGGGMP 336
Cdd:PRK05691 1328 SVWECFwPLITGCRLVLAGPGEH---RDPQRIAELVQQ---YGVTTLHFVPPLLQLFID--EPLAAACTSLRRLFSGGEA 1399
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  337 VQQAVAERWVKLTGQYLLEG-YGLTECAPLVSvnpH----DIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRG 411
Cdd:PRK05691 1400 LPAELRNRVLQRLPQVQLHNrYGPTETAINVT---HwqcqAEDGERSPIGRPLGNVLCRVLDAELNLLPPGVAGELCIGG 1476
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  412 PQVMLGYWQRPDAT------DEIIKDG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVlEV 483
Cdd:PRK05691 1477 AGLARGYLGRPALTaerfvpDPLGEDGarLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGV-AQ 1555
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626  484 AAVGVPSGSSG-EAVKIFVVKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691 1556 AAVLVREGAAGaQLVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRAL 1622
PRK08180 PRK08180
feruloyl-CoA synthase; Reviewed
23-452 3.47e-24

feruloyl-CoA synthase; Reviewed


Pssm-ID: 236175 [Multi-domain]  Cd Length: 614  Bit Score: 106.89  E-value: 3.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFVNMG-----EVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRA 97
Cdd:PRK08180  39 RRLTDRLVHWAQEAPDRVFLAERGadggwRRLTYAEALERVRAIAQALLD-RGLSAERPLMILSGNSIEHALLALAAMYA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  98 GMIVVNVNPLYT-----PRELEHQLN---------DSGAA---AIVIVSnFAHTlEKVVEKTQVKHVILTRMGDQLSTAK 160
Cdd:PRK08180 118 GVPYAPVSPAYSlvsqdFGKLRHVLElltpglvfaDDGAAfarALAAVV-PADV-EVVAVRGAVPGRAATPFAALLATPP 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 161 GTLVNfvvkyvkrlvpkyhlpdaisfrrALHAGyrmqyVKPEivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNA 240
Cdd:PRK08180 196 TAAVD-----------------------AAHAA-----VGPD----TIAKFLFTSGSTGLPKAVINTHRMLCANQQMLAQ 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 241 TYgPLLHPGKELVITALPLYHIFALTMNCLLFIELGGqNVLITNPRDIPGLVKE----LAKYPFTAMTGVNTLFNALLN- 315
Cdd:PRK08180 244 TF-PFLAEEPPVLVDWLPWNHTFGGNHNLGIVLYNGG-TLYIDDGKPTPGGFDEtlrnLREISPTVYFNVPKGWEMLVPa 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 316 ---NKEFQQLDFSTLHLS--AGGGMPvqQAVAERWVKLTGQYLLE------GYGLTECAPLVSvNPHDIDYHSGSIGLPV 384
Cdd:PRK08180 322 lerDAALRRRFFSRLKLLfyAGAALS--QDVWDRLDRVAEATCGErirmmtGLGMTETAPSAT-FTTGPLSRAGNIGLPA 398
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 385 PSTEAKLVddednevPHGEPGELCVRGPQVMLGYWQRPDATDEiikdgwlhtgdiaVMDDEGFLRIVD 452
Cdd:PRK08180 399 PGCEVKLV-------PVGGKLEVRVKGPNVTPGYWRAPELTAE-------------AFDEEGYYRSGD 446
PRK13388 PRK13388
acyl-CoA synthetase; Provisional
353-553 3.97e-24

acyl-CoA synthetase; Provisional


Pssm-ID: 237374 [Multi-domain]  Cd Length: 540  Bit Score: 106.26  E-value: 3.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 LLEGYGLTECAPLVSVNPhdiDYHSGSIGLPVPSTE----------AKLVDDEDNEVPHGEP--GELCVR-GPQVMLGYW 419
Cdd:PRK13388 291 VEDGYGSSEGAVIVVREP---GTPPGSIGRGAPGVAiynpetltecAVARFDAHGALLNADEaiGELVNTaGAGFFEGYY 367
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKI 499
Cdd:PRK13388 368 NNPEATAERMRHGMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPDERVGDQVMA 447
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489956626 500 FVVKKDP-SLTEDALITFCRRQ--LTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK13388 448 ALVLRDGaTFDPDAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKRELIAQG 504
PRK06334 PRK06334
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
74-499 1.10e-23

long chain fatty acid--[acyl-carrier-protein] ligase; Validated


Pssm-ID: 180533 [Multi-domain]  Cd Length: 539  Bit Score: 104.90  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  74 GDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGaaaivivsnfahtlekvvektqVKHVILTR-M 152
Cdd:PRK06334  67 DQHIGIMMPASAGAYIAYFATLLSGKIPVMINWSQGLREVTACANLVG----------------------VTHVLTSKqL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 153 GDQLSTAKGtlvnFVVKYVKRLVPKYHLPDAISFRRALHAGYRMQYVKPEIV---------SEDLAFLQYTGGTTGVAKG 223
Cdd:PRK06334 125 MQHLAQTHG----EDAEYPFSLIYMEEVRKELSFWEKCRIGIYMSIPFEWLMrwfgvsdkdPEDVAVILFTSGTEKLPKG 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 224 AMLTHRNMLANLEQVNATYGPLlhpGKELVITALPLYHIFALTmNCLLFIELGGQNVLIT-NPRDIPGLVKELAKYPFTA 302
Cdd:PRK06334 201 VPLTHANLLANQRACLKFFSPK---EDDVMMSFLPPFHAYGFN-SCTLFPLLSGVPVVFAyNPLYPKKIVEMIDEAKVTF 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 303 MTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERWVKLTGQYLL-EGYGLTECAPLVSVNPHDIDYHSGSIG 381
Cdd:PRK06334 277 LGSTPVFFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIQLrQGYGTTECSPVITINTVNSPKHESCVG 356
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 382 LPVPSTEAKLVDDEDN-EVPHGEPGELCVRGPQVMLGYWQRpDATDEIIK---DGWLHTGDIAVMDDEGFLRIVDRKKDM 457
Cdd:PRK06334 357 MPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYLGE-DFGQGFVElggETWYVTGDLGYVDRHGELFLKGRLSRF 435
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 489956626 458 ILVSGFNVYPNEIEDVVMQHSGVLEVAAVG--VPSGSSGEAVKI 499
Cdd:PRK06334 436 VKIGAEMVSLEALESILMEGFGQNAADHAGplVVCGLPGEKVRL 479
FCS cd05921
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...
201-452 2.01e-23

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.


Pssm-ID: 341245 [Multi-domain]  Cd Length: 561  Bit Score: 104.05  E-value: 2.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 201 PEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpllHPGKE--LVITALPLYHIFALTMNCLLFIELGGq 278
Cdd:cd05921  160 AAVGPDTVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTYP---FFGEEppVLVDWLPWNHTFGGNHNFNLVLYNGG- 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 279 NVLITNPRDIPGLVKELAK--------YPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQQAVAERW----V 346
Cdd:cd05921  236 TLYIDDGKPMPGGFEETLRnlreisptVYFNVPAGWEMLVAALEKDEALRRRFFKRLKLMFYAGAGLSQDVWDRLqalaV 315
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 347 KLTGQY--LLEGYGLTECAPLvSVNPHDIDYHSGSIGLPVPSTEAKLVddednevPHGEPGELCVRGPQVMLGYWQRPDA 424
Cdd:cd05921  316 ATVGERipMMAGLGATETAPT-ATFTHWPTERSGLIGLPAPGTELKLV-------PSGGKYEVRVKGPNVTPGYWRQPEL 387
                        250       260
                 ....*....|....*....|....*...
gi 489956626 425 TdeiikdgwlhtgdIAVMDDEGFLRIVD 452
Cdd:cd05921  388 T-------------AQAFDEEGFYCLGD 402
PRK05691 PRK05691
peptide synthase; Validated
201-549 2.63e-23

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 105.25  E-value: 2.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  201 PEIVS--EDLAFLQYTGGTTGVAKGAMLTHRNMLAN-LEQVnatygPLLHPGKELVItALPLYHIFALTMNCLLFIELGG 277
Cdd:PRK05691 3862 PGIYSgpDNLAYVIYTSGSTGLPKGVMVEQRGMLNNqLSKV-----PYLALSEADVI-AQTASQSFDISVWQFLAAPLFG 3935
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  278 QNVLITnPRDIP----GLVKELAKYPFTAMTGVNTLFNALLNNKEfQQLDFSTLHLSAGGGMPVQqaVAERWVKLTGQY- 352
Cdd:PRK05691 3936 ARVEIV-PNAIAhdpqGLLAHVQAQGITVLESVPSLIQGMLAEDR-QALDGLRWMLPTGEAMPPE--LARQWLQRYPQIg 4011
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  353 LLEGYGLTECAPLVSVNPHDIDYHSGS---IGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQRPDATDEI- 428
Cdd:PRK05691 4012 LVNAYGPAECSDDVAFFRVDLASTRGSylpIGSPTDNNRLYLLDEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAf 4091
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  429 -------IKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEvAAVGVPSGSSGEAVKIFV 501
Cdd:PRK05691 4092 vphpfgaPGERLYRTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVRE-AAVAVQEGVNGKHLVGYL 4170
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489956626  502 VKKDPSLTEDALITFCRRQLTG----YKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691 4171 VPHQTVLAQGALLERIKQRLRAelpdYMVPLHWLWLDRLPLNANGKLDRKAL 4222
PRK05851 PRK05851
long-chain-fatty acid--ACP ligase MbtM;
205-550 1.42e-22

long-chain-fatty acid--ACP ligase MbtM;


Pssm-ID: 180289 [Multi-domain]  Cd Length: 525  Bit Score: 101.38  E-value: 1.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 SEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITALPLYHIFALTMncLLFIELGGQnvlitn 284
Cdd:PRK05851 151 SGGPAVLQGTAGSTGTPRTAILSPGAVLSNLRGLNARVG--LDAATDVGCSWLPLYHDMGLAF--LLTAALAGA------ 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 285 prdipglvkELAKYPFTA-----------MTGVNTLFNALLN---------NKEFQQLDFSTLHLSAGGGMPVQQAVAER 344
Cdd:PRK05851 221 ---------PLWLAPTTAfsaspfrwlswLSDSRATLTAAPNfaynligkyARRVSDVDLGALRVALNGGEPVDCDGFER 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 345 WVKLTGQY------LLEGYGLTE--CAPLVSVnP------HDIDYHSGS-------IGLPVPSTEAKLV-DDEDNEVPHG 402
Cdd:PRK05851 292 FATAMAPFgfdagaAAPSYGLAEstCAVTVPV-PgiglrvDEVTTDDGSgarrhavLGNPIPGMEVRISpGDGAAGVAGR 370
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 403 EPGELCVRGPQVMLGYWqrpdATDEIIKDGWLHTGDIAVMDDEGfLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLE 482
Cdd:PRK05851 371 EIGEIEIRGASMMSGYL----GQAPIDPDDWFPTGDLGYLVDGG-LVVCGRAKELITVAGRNIFPTEIERVAAQVRGVRE 445
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489956626 483 --VAAVGVPSGS--SGEAVKIFVVKKDPSLTEDALITFCRRQlTGYkVPKLVEFRD--ELPKSNVGKILRRELR 550
Cdd:PRK05851 446 gaVVAVGTGEGSarPGLVIAAEFRGPDEAGARSEVVQRVASE-CGV-VPSDVVFVApgSLPRTSSGKLRRLAVK 517
PRK00174 PRK00174
acetyl-CoA synthetase; Provisional
37-553 2.25e-22

acetyl-CoA synthetase; Provisional


Pssm-ID: 234677 [Multi-domain]  Cd Length: 637  Bit Score: 101.37  E-value: 2.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  37 ADQPAFVNMGE------VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMI--VVNVNplY 108
Cdd:PRK00174  81 GDKVAIIWEGDdpgdsrKITYRELHREVCRFANALKS-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVhsVVFGG--F 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 109 TPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVEK-----TQVKHVIltrmgdqlstakgtlvnfVVKYVKRLVP-- 176
Cdd:PRK00174 158 SAEALADRIIDAGAKLVITADEGvrggkPIPLKANVDEalancPSVEKVI------------------VVRRTGGDVDwv 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 177 -----KYHlpDAISFRRAlhagyrmqYVKPEIV-SEDLAFLQYTGGTTGVAKG-----------AMLTHRNML------- 232
Cdd:PRK00174 220 egrdlWWH--ELVAGASD--------ECEPEPMdAEDPLFILYTSGSTGKPKGvlhttggylvyAAMTMKYVFdykdgdv 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 233 ----ANLEQVNA----TYGPLLHPGKELVITALPLY-------HIfaltmncllfIELGGQNVLITNPRDIPGLVKELAK 297
Cdd:PRK00174 290 ywctADVGWVTGhsyiVYGPLANGATTLMFEGVPNYpdpgrfwEV----------IDKHKVTIFYTAPTAIRALMKEGDE 359
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 298 YPftamtgvntlfnallnnkefQQLDFSTLHLSAGGGMPV--------QQAV-AER-------WVKLTGQYLLegyglte 361
Cdd:PRK00174 360 HP--------------------KKYDLSSLRLLGSVGEPInpeawewyYKVVgGERcpivdtwWQTETGGIMI------- 412
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 362 cAPLvsvnPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRG--PQVMLGYWQRPD-------ATdeiIKDG 432
Cdd:PRK00174 413 -TPL----PGATPLKPGSATRPLPGIQPAVVDEEGNPLEGGEGGNLVIKDpwPGMMRTIYGDHErfvktyfST---FKGM 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 433 WLhTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDA 512
Cdd:PRK00174 485 YF-TGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVGRPDDIKGQGIYAFVTLKGGEEPSDE 563
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 489956626 513 LIT----FCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK00174 564 LRKelrnWVRKEIGPIAKPDVIQFAPGLPKTRSGKIMRRILRKIA 608
A_NRPS_ACVS-like cd17648
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...
38-549 3.02e-22

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.


Pssm-ID: 341303 [Multi-domain]  Cd Length: 453  Bit Score: 99.78  E-value: 3.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17648    2 DRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIRPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFIL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 118 NDSGAAAIVivsnfahtlekvvekTQVKhviltrmgdqlstakgtlvnfvvkyvkrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17648   82 EDTGARVVI---------------TNST---------------------------------------------------- 94
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 198 yvkpeivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGpLLHPGKElVITALPLYhIFALTMNCLLFIELGG 277
Cdd:cd17648   95 ---------DLAYAIYTSGTTGKPKGVLVEHGSVVNLRTSLSERYF-GRDNGDE-AVLFFSNY-VFDFFVEQMTLALLNG 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 278 QNVLITNPR---DIPGLVKELAKYPFTAMTGVNTLFnallnnkefQQLDFSTL-HL----SAGggmpvQQAVAERWVKLT 349
Cdd:cd17648  163 QKLVVPPDEmrfDPDRFYAYINREKVTYLSGTPSVL---------QQYDLARLpHLkrvdAAG-----EEFTAPVFEKLR 228
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 350 GQY---LLEGYGLTEcaplVSVNPHDIDYHSG-----SIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGPQVMLGYWQR 421
Cdd:cd17648  229 SRFaglIINAYGPTE----TTVTNHKRFFPGDqrfdkSLGRPVRNTKCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNR 304
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 422 PD-----------ATDEIIKDG----WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAV 486
Cdd:cd17648  305 PEltaerflpnpfQTEQERARGrnarLYKTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVV 384
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489956626 487 G--VPSGSSGEAVKIFV---VKKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17648  385 AkeDASQAQSRIQKYLVgyyLPEPGHVPESDLLSFLRAKLPRYMVPARLVRLEGIPVTINGKLDVRAL 452
prpE PRK10524
propionyl-CoA synthetase; Provisional
31-550 7.01e-22

propionyl-CoA synthetase; Provisional


Pssm-ID: 182517 [Multi-domain]  Cd Length: 629  Bit Score: 99.64  E-value: 7.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  31 HSVRRyADQPAFV------NMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:PRK10524  62 HLAKR-PEQLALIavstetDEERTYTFRQLHDEVNRMAAMLRS-LGVQRGDRVLIYMPMIAEAAFAMLACARIGAIHSVV 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 105 NPLYTPRELEHQLNDsgAAAIVIVS-----------NFAHTLEKVVEKTQVK--HVILTRMGdqlsTAKGTLVNfvvkyv 171
Cdd:PRK10524 140 FGGFASHSLAARIDD--AKPVLIVSadagsrggkvvPYKPLLDEAIALAQHKprHVLLVDRG----LAPMARVA------ 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 172 KRLVPKYHLpdaisfrRALHAGYRmqyVKPEIV-SEDLAFLQYTGGTTGVAKGAmltHRNMlanleqvnatygpllhpGK 250
Cdd:PRK10524 208 GRDVDYATL-------RAQHLGAR---VPVEWLeSNEPSYILYTSGTTGKPKGV---QRDT-----------------GG 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 251 ELVITALPLYHIF----ALTMNCLLFIE-------------LGGQNVLI---TNPRDIPGLVKEL-AKYpftamtGVNTL 309
Cdd:PRK10524 258 YAVALATSMDTIFggkaGETFFCASDIGwvvghsyivyaplLAGMATIMyegLPTRPDAGIWWRIvEKY------KVNRM 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 310 FNA-----LLNNKEFQQL---DFSTLHLSAGGGMPVQQAVAeRWVKLT-GQYLLEGYGLTECA-PLVSVNP--HDIDYHS 377
Cdd:PRK10524 332 FSAptairVLKKQDPALLrkhDLSSLRALFLAGEPLDEPTA-SWISEAlGVPVIDNYWQTETGwPILAIARgvEDRPTRL 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 378 GSIGLPVPSTEAKLVDDEDNE-VPHGEPGELCVRGP---QVMLGYWqRPDatDEIIKDGWLH-------TGDIAVMDDEG 446
Cdd:PRK10524 411 GSPGVPMYGYNVKLLNEVTGEpCGPNEKGVLVIEGPlppGCMQTVW-GDD--DRFVKTYWSLfgrqvysTFDWGIRDADG 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 447 FLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDA---------LITFC 517
Cdd:PRK10524 488 YYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVGVKDALKGQVAVAFVVPKDSDSLADRearlalekeIMALV 567
                        570       580       590
                 ....*....|....*....|....*....|...
gi 489956626 518 RRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK10524 568 DSQLGAVARPARVWFVSALPKTRSGKLLRRAIQ 600
PLN02430 PLN02430
long-chain-fatty-acid-CoA ligase
327-461 7.08e-22

long-chain-fatty-acid-CoA ligase


Pssm-ID: 178049 [Multi-domain]  Cd Length: 660  Bit Score: 99.89  E-value: 7.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 327 LHLSAGGGMPVQQAVaERWVKLTG-QYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLvdDEDNEV---PHG 402
Cdd:PLN02430 385 LRLLISGGAPLSTEI-EEFLRVTScAFVVQGYGLTETLGPTTLGFPDEMCMLGTVGAPAVYNELRL--EEVPEMgydPLG 461
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626 403 EP--GELCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:PLN02430 462 EPprGEICVRGKCLFSGYYKNPELTEEVMKDGWFHTGDIGEILPNGVLKIIDRKKNLIKLS 522
hsFATP2a_ACSVL_like cd05938
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ...
46-536 7.28e-22

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341261 [Multi-domain]  Cd Length: 537  Bit Score: 99.29  E-value: 7.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  46 GEVMTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05938    3 GETYTYRDVDRRSNQAARALLAHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 VIVSNFAHTLEKVVEKTQVKHVILTRMGDQLSTAK-GTLVNFVVKYVKRLVPKYhLPDAISFRralhagyrmqyvkpeiv 204
Cdd:cd05938   83 VVAPELQEAVEEVLPALRADGVSVWYLSHTSNTEGvISLLDKVDAASDEPVPAS-LRAHVTIK----------------- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 205 seDLAFLQYTGGTTGVAKGAMLTHRNMLanleQVNATYgPLLHPGKELVI-TALPLYHIFALTMNCLLFIELGGQNVLIT 283
Cdd:cd05938  145 --SPALYIYTSGTTGLPKAARISHLRVL----QCSGFL-SLCGVTADDVIyITLPLYHSSGFLLGIGGCIELGATCVLKP 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 284 nprdipglvK--------ELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmpVQQAVAERWVKLTGQ-YLL 354
Cdd:cd05938  218 ---------KfsasqfwdDCRKHNVTVIQYIGELLRYLCNQPQSPNDRDHKVRLAIGNG--LRADVWREFLRRFGPiRIR 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 355 EGYGLTECaplvsvNPHDIDY--HSGSIG-------LPVP-------STEAKLVDDEDN---EVPHGEPGELC--VRGPQ 413
Cdd:cd05938  287 EFYGSTEG------NIGFFNYtgKIGAVGrvsylykLLFPfelikfdVEKEEPVRDAQGfciPVAKGEPGLLVakITQQS 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 414 VMLGYWQRPDATD-----EIIKDG--WLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAV 486
Cdd:cd05938  361 PFLGYAGDKEQTEkkllrDVFKKGdvYFNTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVNVY 440
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489956626 487 GVP-SGSSGEAVKIFVVKKDP-SLTEDALITFCRRQLTGYKVPKLVEFRDEL 536
Cdd:cd05938  441 GVTvPGHEGRIGMAAVKLKPGhEFDGKKLYQHVREYLPAYARPRFLRIQDSL 492
PRK05691 PRK05691
peptide synthase; Validated
23-549 2.54e-21

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 99.09  E-value: 2.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQE-GLGLQKgdRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK05691 2188 QTLHGLFAAQAARTPQAPALTFAGQTLSYAELDARANRLARALRErGVGPQV--RVGLALERSLEMVVGLLAILKAGGAY 2265
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  102 VNVNPLYTPRELEHQLNDSGaaaIVIVSNFAHTLEKVVE-KTQVKHVILTRMGDQLSTakgtlvnfvvkYVKRLVPKYHL 180
Cdd:PRK05691 2266 VPLDPEYPLERLHYMIEDSG---IGLLLSDRALFEALGElPAGVARWCLEDDAAALAA-----------YSDAPLPFLSL 2331
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  181 PDaisfrralhagyrmqyvkpeivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKelviTALPLY 260
Cdd:PRK05691 2332 PQ------------------------HQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFG--MRADD----CELHFY 2381
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  261 HI-FALTMNCLLFIELGGQNVLIT-----NPRDIPGLVKELAkypfTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:PRK05691 2382 SInFDAASERLLVPLLCGARVVLRaqgqwGAEEICQLIREQQ----VSILGFTPSYGSQLAQWLAGQGEQLPVRMCITGG 2457
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  335 mpvQQAVAERWVKLTG----QYLLEGYGLTECA--PLVSVNPHDIDYHSGS--IGLPVPSTEAKLVDDEDNEVPHGEPGE 406
Cdd:PRK05691 2458 ---EALTGEHLQRIRQafapQLFFNAYGPTETVvmPLACLAPEQLEEGAASvpIGRVVGARVAYILDADLALVPQGATGE 2534
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  407 LCVRGPQVMLGYWQRPDATDE-IIKDGWLH-------TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHS 478
Cdd:PRK05691 2535 LYVGGAGLAQGYHDRPGLTAErFVADPFAAdggrlyrTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLEHP 2614
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  479 GVLE--VAAVGVPsgsSGEAVKIFVVKKDPSLTED-------ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691 2615 AVREavVLALDTP---SGKQLAGYLVSAVAGQDDEaqaalreALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRAL 2691
PRK04813 PRK04813
D-alanine--poly(phosphoribitol) ligase subunit DltA;
23-555 1.23e-20

D-alanine--poly(phosphoribitol) ligase subunit DltA;


Pssm-ID: 235313 [Multi-domain]  Cd Length: 503  Bit Score: 95.35  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  23 QSLIELFEHSVRRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVAL---MMPNLLqypVALFGILRAGM 99
Cdd:PRK04813   2 MDIIETIEEFAQTQPDFPAYDYLGEKLTYGQLKEDSDALAAFIDS-LKLPDKSPIIVfghMSPEML---ATFLGAVKAGH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 100 IVVNVNpLYTPRELEHQLNDSGAAAIVIvsnfaHTLEKVVEKTQVKHVILtrmgDQLSTAKGTLVNFVVKyvkrlvpkyh 179
Cdd:PRK04813  78 AYIPVD-VSSPAERIEMIIEVAKPSLII-----ATEELPLEILGIPVITL----DELKDIFATGNPYDFD---------- 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 180 lpdaisfrralhagyrmQYVKPEivseDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGPllhpGKELVITALPL 259
Cdd:PRK04813 138 -----------------HAVKGD----DNYYIIFTSGTTGKPKGVQISHDNLVSFTNWMLEDFAL----PEGPQFLNQAP 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 260 YHiFALT-MN---CLLfieLGGQNV-----LITNPRDipgLVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLH 328
Cdd:PRK04813 193 YS-FDLSvMDlypTLA---SGGTLValpkdMTANFKQ---LFETLPQLPINVWVSTPSFADMCLLDPSFneEHLPNLTHF 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 329 LSAGGGMPVQ--QAVAERWVKLTgqyLLEGYGLTECAPLVS---VNPHDID-YHSGSIGLPVPSTEAKLVDDEDNEVPHG 402
Cdd:PRK04813 266 LFCGEELPHKtaKKLLERFPSAT---IYNTYGPTEATVAVTsieITDEMLDqYKRLPIGYAKPDSPLLIIDEEGTKLPDG 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 403 EPGELCVRGPQVMLGYWQRPDATDEIIK--DGW--LHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHS 478
Cdd:PRK04813 343 EQGEIVISGPSVSKGYLNNPEKTAEAFFtfDGQpaYHTGDAGYLED-GLLFYQGRIDFQIKLNGYRIELEEIEQNLRQSS 421
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 479 GVLEvaAVGVPSGSSGEAVKI--FVVKKDPSLTEDALITFCRRQ-----LTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK04813 422 YVES--AVVVPYNKDHKVQYLiaYVVPKEEDFEREFELTKAIKKelkerLMEYMIPRKFIYRDSLPLTPNGKIDRKALIE 499

                 ....
gi 489956626 552 EARA 555
Cdd:PRK04813 500 EVNK 503
PLN02861 PLN02861
long-chain-fatty-acid-CoA ligase
207-511 5.66e-20

long-chain-fatty-acid-CoA ligase


Pssm-ID: 178452 [Multi-domain]  Cd Length: 660  Bit Score: 93.75  E-value: 5.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnleQVNATYGPLLHPGK-----ELVITALPLYHIFALTMNcLLFIELGG---- 277
Cdd:PLN02861 221 DICTIMYTSGTTGEPKGVILTNRAIIA---EVLSTDHLLKVTDRvateeDSYFSYLPLAHVYDQVIE-TYCISKGAsigf 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 278 ---------QNVLITNPR---DIP------------------GLVKELAKYPFTAMTG----------VNTLFNALLNNK 317
Cdd:PLN02861 297 wqgdirylmEDVQALKPTifcGVPrvydriytgimqkissggMLRKKLFDFAYNYKLGnlrkglkqeeASPRLDRLVFDK 376
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 318 EFQQLDfSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVD---- 393
Cdd:PLN02861 377 IKEGLG-GRVRLLLSGAAPLPRHVEEFLRVTSCSVLSQGYGLTESCGGCFTSIANVFSMVGTVGVPMTTIEARLESvpem 455
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 394 --DEDNEVPHGEpgeLCVRGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS-GFNVYPNEI 470
Cdd:PLN02861 456 gyDALSDVPRGE---ICLRGNTLFSGYHKRQDLTEEVLIDGWFHTGDIGEWQPNGAMKIIDRKKNIFKLSqGEYVAVENL 532
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 489956626 471 EDVVMQHSgvlEVAAVGVpSGSSGEAVKIFVVKKDPSLTED 511
Cdd:PLN02861 533 ENTYSRCP---LIASIWV-YGNSFESFLVAVVVPDRQALED 569
PRK07445 PRK07445
O-succinylbenzoic acid--CoA ligase; Reviewed
357-551 1.24e-19

O-succinylbenzoic acid--CoA ligase; Reviewed


Pssm-ID: 236019 [Multi-domain]  Cd Length: 452  Bit Score: 91.59  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 357 YGLTECAPLVSV-NPHDIDYHSGSIGLPVPstEAKLvddednEVPHGEPGELCVRGPQVMLGYWqrPDATDeiiKDGWLH 435
Cdd:PRK07445 261 YGMTETASQIATlKPDDFLAGNNSSGQVLP--HAQI------TIPANQTGNITIQAQSLALGYY--PQILD---SQGIFE 327
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 436 TGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVVKKDPSLTEDALIT 515
Cdd:PRK07445 328 TDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLVQDVCVLGLPDPHWGEVVTAIYVPKDPSISLEELKT 407
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489956626 516 FCRRQLTGYKVPK---LVEfrdELPKSNVGKILRRELRD 551
Cdd:PRK07445 408 AIKDQLSPFKQPKhwiPVP---QLPRNPQGKINRQQLQQ 443
PRK09029 PRK09029
O-succinylbenzoic acid--CoA ligase; Provisional
35-560 6.16e-19

O-succinylbenzoic acid--CoA ligase; Provisional


Pssm-ID: 236363 [Multi-domain]  Cd Length: 458  Bit Score: 89.55  E-value: 6.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPlytprele 114
Cdd:PRK09029  15 VRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQ-QGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNP-------- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 115 hQLNDSgaaaivivsnfahTLEKVVEKTQVKHvILTRMGDQLSTAKGTLvnfvvkyvkrLVPKYHLPDAISFRralhagy 194
Cdd:PRK09029  86 -QLPQP-------------LLEELLPSLTLDF-ALVLEGENTFSALTSL----------HLQLVEGAHAVAWQ------- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 195 rmqyvkpeivSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNA--TYGP----LLhpgkelvitALPLYHI------ 262
Cdd:PRK09029 134 ----------PQRLATMTLTSGSTGLPKAAVHTAQAHLASAEGVLSlmPFTAqdswLL---------SLPLFHVsgqgiv 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 263 ----FAltmncllfielGGQNVLitnpRDIPGLVKELAKypFTAMTGVNTLFNALLNNKefqQLDFSTLHLSAGGGM-PV 337
Cdd:PRK09029 195 wrwlYA-----------GATLVV----RDKQPLEQALAG--CTHASLVPTQLWRLLDNR---SEPLSLKAVLLGGAAiPV 254
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 338 ---QQAVA---ERWVkltgqylleGYGLTECAPLVSVNPhdIDYHSGsIGLPVPSTEAKLVDDEdnevphgepgeLCVRG 411
Cdd:PRK09029 255 eltEQAEQqgiRCWC---------GYGLTEMASTVCAKR--ADGLAG-VGSPLPGREVKLVDGE-----------IWLRG 311
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 412 PQVMLGYWQ----RPdATDEiikDGWLHTGDIAVMDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVG 487
Cdd:PRK09029 312 ASLALGYWRqgqlVP-LVND---EGWFATRDRGEWQN-GELTILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFVVP 386
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 488 VPSGSSGE---AvkifVVKKDPSLTEDALITFCRRQLTGYKVPklVEF---RDELPKSNVgKILRRELRDEARAKVDNK 560
Cdd:PRK09029 387 VADAEFGQrpvA----VVESDSEAAVVNLAEWLQDKLARFQQP--VAYyllPPELKNGGI-KISRQALKEWVAQQLGNN 458
Dip2 cd05905
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of ...
50-485 1.14e-18

Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of the adenylate forming enzyme family, including insect luciferase, acetyl CoA ligases and the adenylation domain of nonribosomal peptide synthetases (NRPS). However, its function may have diverged from other members of the superfamily. In mouse embryo, Dip2 homolog A plays an important role in the development of both vertebrate and invertebrate nervous systems. Dip2A appears to regulate cell growth and the arrangement of cells in organs. Biochemically, Dip2A functions as a receptor of FSTL1, an extracellular glycoprotein, and may play a role as a cardiovascular protective agent.


Pssm-ID: 341231 [Multi-domain]  Cd Length: 571  Bit Score: 89.33  E-value: 1.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEhqlndsgaaaiVIVS 129
Cdd:cd05905   16 TWGKLLSRAEKIAAVLQKKVGLKPGDRVALMYPDPLDFVAAFYGCLYAGVVPIPIEPPDISQQLG-----------FLLG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 130 NFAHTLEKVVEKTQVKHVILTRmgdqLSTAKGTLVNfvvkyvKRLVPKYHLPDAISFRRALHAgyRMQYVKPEIVSEDLA 209
Cdd:cd05905   85 TCKVRVALTVEACLKGLPKKLL----KSKTAAEIAK------KKGWPKILDFVKIPKSKRSKL--KKWGPHPPTRDGDTA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 210 FLQYTGGTTGVAKGAMLTHRNMLA---NLEQVNATYgpllhpGKELVITALPLYHIFALTMNCLLFIELGGQNVLI---- 282
Cdd:cd05905  153 YIEYSFSSDGSLSGVAVSHSSLLAhcrALKEACELY------ESRPLVTVLDFKSGLGLWHGCLLSVYSGHHTILIppel 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 283 --TNPrdiPGLVKELAKYP-FTAMTGVNTLFNALLN-NKEFQQLDFSTLHLS------AGGGMPVQQAVAERWVKL---- 348
Cdd:cd05905  227 mkTNP---LLWLQTLSQYKvRDAYVKLRTLHWCLKDlSSTLASLKNRDVNLSslrmcmVPCENRPRISSCDSFLKLfqtl 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 349 ----------------------------TGQYLLEGYGLTECAP-LVSVN-PHDIDYHSGsiGLPVPSTEAKLVDDEdnE 398
Cdd:cd05905  304 glspravstefgtrvnpficwqgtsgpePSRVYLDMRALRHGVVrLDERDkPNSLPLQDS--GKVLPGAQVAIVNPE--T 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 399 VPH---GEPGELCVRGPQVMLGYWQRPDATDEIIKD-------------GWLHTGDI----------AVMDDEGFLRIVD 452
Cdd:cd05905  380 KGLckdGEIGEIWVNSPANASGYFLLDGETNDTFKVfpstrlstgitnnSYARTGLLgflrptkctdLNVEEHDLLFVVG 459
                        490       500       510
                 ....*....|....*....|....*....|....
gi 489956626 453 RKKDMILVSGFNVYPNEIEDVVMQ-HSGVLEVAA 485
Cdd:cd05905  460 SIDETLEVRGLRHHPSDIEATVMRvHPYRGRCAV 493
AMP-binding_C pfam13193
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...
469-543 1.23e-18

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.


Pssm-ID: 463804 [Multi-domain]  Cd Length: 76  Bit Score: 80.28  E-value: 1.23e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489956626  469 EIEDVVMQHSGVLEVAAVGVPSGSSGEAVKIFVV-KKDPSLTEDALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:pfam13193   1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVlKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
FATP_chFAT1_like cd05937
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...
206-552 2.14e-17

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.


Pssm-ID: 341260 [Multi-domain]  Cd Length: 468  Bit Score: 84.79  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANlEQVNATYgplLHPGKEL-VITALPLYHIFAL---TMNCLLFielGGQNVL 281
Cdd:cd05937   87 DDPAILIYTSGTTGLPKAAAISWRRTLVT-SNLLSHD---LNLKNGDrTYTCMPLYHGTAAflgACNCLMS---GGTLAL 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 282 -------------ITNPRDIPGLVKELAKYpftamtgvntLFNALLNNKEFQQldfsTLHLSAGGGM--PVQQAVAERW- 345
Cdd:cd05937  160 srkfsasqfwkdvRDSGATIIQYVGELCRY----------LLSTPPSPYDRDH----KVRVAWGNGLrpDIWERFRERFn 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 346 VKLTGQYllegYGLTEcAPLVSVNPHDIDYHSGSIGL--------------PV---PSTEAKLVDDEDN---EVPHGEPG 405
Cdd:cd05937  226 VPEIGEF----YAATE-GVFALTNHNVGDFGAGAIGHhglirrwkfenqvvLVkmdPETDDPIRDPKTGfcvRAPVGEPG 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 406 ELCVRGPQVML----GYWQRPDATD-EIIK------DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:cd05937  301 EMLGRVPFKNReafqGYLHNEDATEsKLVRdvfrkgDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVL 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 475 MQHSGVLEVAAVGVP-SGSSGEAVKIFVVKKDPSLTEDALI-----TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:cd05937  381 GAHPDIAEANVYGVKvPGHDGRAGCAAITLEESSAVPTEFTksllaSLARKNLPSYAVPLFLRLTEEVATTDNHKQQKGV 460

                 ....
gi 489956626 549 LRDE 552
Cdd:cd05937  461 LRDE 464
AFD_CAR-like cd17632
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ...
35-461 6.91e-17

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.


Pssm-ID: 341287 [Multi-domain]  Cd Length: 588  Bit Score: 84.04  E-value: 6.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  35 RYADQPAF------VNMGEV--------------MTFRKLEERSRAFAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGI 94
Cdd:cd17632   34 GYADRPALgqrateLVTDPAtgrttlrllprfetITYAELWERVGAVAAAHDPEQPVRPGDFVAVLGFTSPDYATVDLAL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  95 LRAGMIVVnvnPLYT---PRELEHQLNDSGAAAI-VIVSNFAHTLEKVVEKTQVKHVI-------LTRMGDQLSTAKGTL 163
Cdd:cd17632  114 TRLGAVSV---PLQAgasAAQLAPILAETEPRLLaVSAEHLDLAVEAVLEGGTPPRLVvfdhrpeVDAHRAALESARERL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 164 VNFVVKYVkrlvpkyhLPDAISFR-RALHAGYRMqyvKPEIVSEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATY 242
Cdd:cd17632  191 AAVGIPVT--------TLTLIAVRgRDLPPAPLF---RPEPDDDPLALLIYTSGSTGTPKGAMYTERLVATFWLKVSSIQ 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 243 GPllHPGKELVITALPLYHIfaltmncllfielGGQNVLITnprdipGLVKELAKYpFTAMTGVNTLFN--ALLNNKE-- 318
Cdd:cd17632  260 DI--RPPASITLNFMPMSHI-------------AGRISLYG------TLARGGTAY-FAAASDMSTLFDdlALVRPTElf 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 319 ---------FQQLDFSTLHLSAGGGMPV---QQAVAE-RWVKLTGQY-------------------------LLEGYGLT 360
Cdd:cd17632  318 lvprvcdmlFQRYQAELDRRSVAGADAEtlaERVKAElRERVLGGRLlaavcgsaplsaemkafmeslldldLHDGYGST 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 361 EcAPLVSVNphdidyhsGSIGLPvPSTEAKLVDDED-----NEVPHgeP-GELCVRGPQVMLGYWQRPDATDEII-KDGW 433
Cdd:cd17632  398 E-AGAVILD--------GVIVRP-PVLDYKLVDVPElgyfrTDRPH--PrGELLVKTDTLFPGYYKRPEVTAEVFdEDGF 465
                        490       500
                 ....*....|....*....|....*...
gi 489956626 434 LHTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:cd17632  466 YRTGDVMAELGPDRLVYVDRRNNVLKLS 493
PLN02654 PLN02654
acetate-CoA ligase
49-558 1.81e-16

acetate-CoA ligase


Pssm-ID: 215353 [Multi-domain]  Cd Length: 666  Bit Score: 82.64  E-value: 1.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAIVIV 128
Cdd:PLN02654 121 LTYSELLDRVCQLANYLKD-VGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDC-KPKVVIT 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 129 SNFAHTLEKVVEKTQVKHVILTRmgdqlSTAKGTLVNFVVKY-----VKRLVPKYHLPDAISFRRALhAGYRMQYVKPEI 203
Cdd:PLN02654 199 CNAVKRGPKTINLKDIVDAALDE-----SAKNGVSVGICLTYenqlaMKREDTKWQEGRDVWWQDVV-PNYPTKCEVEWV 272
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 204 VSEDLAFLQYTGGTTGVAKGAMLTHRNML----------------------ANLEQVNA----TYGPLLHPGKELVITAL 257
Cdd:PLN02654 273 DAEDPLFLLYTSGSTGKPKGVLHTTGGYMvytattfkyafdykptdvywctADCGWITGhsyvTYGPMLNGATVLVFEGA 352
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 258 PLYhifaltmncllfielggqnvlitnPRdiPGLVKELA-KYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG--G 334
Cdd:PLN02654 353 PNY------------------------PD--SGRCWDIVdKYKVTIFYTAPTLVRSLMRDGDEYVTRHSRKSLRVLGsvG 406
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 335 MPVQQAvAERWV-KLTG-----------QYLLEGYGLTecaPLVSVNPHDidyhSGSIGLPVPSTEAKLVDDEDNEVPHG 402
Cdd:PLN02654 407 EPINPS-AWRWFfNVVGdsrcpisdtwwQTETGGFMIT---PLPGAWPQK----PGSATFPFFGVQPVIVDEKGKEIEGE 478
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 403 EPGELCVRGP-----QVMLGYWQRPDATDEIIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQH 477
Cdd:PLN02654 479 CSGYLCVKKSwpgafRTLYGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSH 558
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 478 SGVLEVAAVGVPSGSSGEAVKIFVVKKDP-SLTED---ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PLN02654 559 PQCAEAAVVGIEHEVKGQGIYAFVTLVEGvPYSEElrkSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILRKIA 638

                 ....*
gi 489956626 554 RAKVD 558
Cdd:PLN02654 639 SRQLD 643
PTZ00342 PTZ00342
acyl-CoA synthetase; Provisional
194-461 4.12e-16

acyl-CoA synthetase; Provisional


Pssm-ID: 240370 [Multi-domain]  Cd Length: 746  Bit Score: 81.69  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 194 YRMQYVKPEIVSEdlafLQYTGGTTGVAKGAMLTHRNMLANL-----EQVNATYGPLLHpgkelvITALPLYHIFALTMN 268
Cdd:PTZ00342 296 YKIQNEDPDFITS----IVYTSGTSGKPKGVMLSNKNLYNTVvplckHSIFKKYNPKTH------LSYLPISHIYERVIA 365
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 269 CLLFIeLGGQnVLITNpRDIPGLVKELAKYPFTAMTGVNTLFNALL----------------------------NNKEFQ 320
Cdd:PTZ00342 366 YLSFM-LGGT-INIWS-KDINYFSKDIYNSKGNILAGVPKVFNRIYtnimteinnlpplkrflvkkilslrksnNNGGFS 442
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 321 QLDFSTLHLSA---------------GGGMPVQQAVAERWVKLTGQYLlEGYGLTECAPLVSVNPHDiDYHSGSIGLPV- 384
Cdd:PTZ00342 443 KFLEGITHISSkikdkvnpnlevilnGGGKLSPKIAEELSVLLNVNYY-QGYGLTETTGPIFVQHAD-DNNTESIGGPIs 520
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489956626 385 PSTEAKLVDDEDNEVPHGEP-GELCVRGPQVMLGYWQRPDATDE-IIKDGWLHTGDIAVMDDEGFLRIVDRKKDMILVS 461
Cdd:PTZ00342 521 PNTKYKVRTWETYKATDTLPkGELLIKSDSIFSGYFLEKEQTKNaFTEDGYFKTGDIVQINKNGSLTFLDRSKGLVKLS 599
PTZ00237 PTZ00237
acetyl-CoA synthetase; Provisional
210-546 2.66e-11

acetyl-CoA synthetase; Provisional


Pssm-ID: 240325 [Multi-domain]  Cd Length: 647  Bit Score: 66.30  E-value: 2.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 210 FLQYTGGTTGVAKGAMlthRNMLANLEQVNATYGPLLHPGKELVItaLPLYHIFALTMNCLLFIELGGQNVL------IT 283
Cdd:PTZ00237 258 YILYTSGTTGNSKAVV---RSNGPHLVGLKYYWRSIIEKDIPTVV--FSHSSIGWVSFHGFLYGSLSLGNTFvmfeggII 332
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 284 NPRDIP-GLVKELAKYPFT-AMTGVNTLFNALLNNKEFQQL----DFSTLHLSAGGGMPVQQAVAERWVKLTGQYLLEGY 357
Cdd:PTZ00237 333 KNKHIEdDLWNTIEKHKVThTLTLPKTIRYLIKTDPEATIIrskyDLSNLKEIWCGGEVIEESIPEYIENKLKIKSSRGY 412
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 358 GLTE--CAPLVSVNPHDIDYHSgsIGLPVPSTEAKLVDDEDNEVPHGEPGELCVR---GPQVMLGYWQRpdatDEIIKD- 431
Cdd:PTZ00237 413 GQTEigITYLYCYGHINIPYNA--TGVPSIFIKPSILSEDGKELNVNEIGEVAFKlpmPPSFATTFYKN----DEKFKQl 486
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 432 -----GWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGSSGEA-VKIFVVKKD 505
Cdd:PTZ00237 487 fskfpGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSIGIYDPDCYNVpIGLLVLKQD 566
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 489956626 506 PSLTEDALITF-------CRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:PTZ00237 567 QSNQSIDLNKLkneinniITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
PaaK COG1541
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...
320-480 1.12e-07

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];


Pssm-ID: 441150 [Multi-domain]  Cd Length: 423  Bit Score: 54.38  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 320 QQLDFSTLHLSAG--GGMPV----QQAVAERW-VKLtgqylLEGYGLTECAPLVSVNPHDIDyhsgsiGLPVPS----TE 388
Cdd:COG1541  196 EGIDPRDLSLKKGifGGEPWseemRKEIEERWgIKA-----YDIYGLTEVGPGVAYECEAQD------GLHIWEdhflVE 264
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 389 akLVDDEDNE-VPHGEPGELCV----RGPQVMLGYwqrpdatdeiikdgwlHTGDIAVMDDEG---------FLRIVDRK 454
Cdd:COG1541  265 --IIDPETGEpVPEGEEGELVVttltKEAMPLIRY----------------RTGDLTRLLPEPcpcgrthprIGRILGRA 326
                        170       180
                 ....*....|....*....|....*.
gi 489956626 455 KDMILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:COG1541  327 DDMLIIRGVNVFPSQIEEVLLRIPEV 352
PLN03052 PLN03052
acetate--CoA ligase; Provisional
49-552 2.93e-07

acetate--CoA ligase; Provisional


Pssm-ID: 215553 [Multi-domain]  Cd Length: 728  Bit Score: 53.54  E-value: 2.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  49 MTFRKLEERSRAfAAYLQEGLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI--- 125
Cdd:PLN03052 209 MTLSELRSQVSR-VANALDALGFEKGDAIAIDMPMNVHAVIIYLAIILAGCVVVSIADSFAPSEIATRLKISKAKAIftq 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 126 -VIV-SNFAHTL-EKVVEKTQVKHVILtrmgdqlsTAKGTLVNFVVKyVKRLVPKYHLPDAISFRRAlhagyrMQYVKPE 202
Cdd:PLN03052 288 dVIVrGGKSIPLySRVVEAKAPKAIVL--------PADGKSVRVKLR-EGDMSWDDFLARANGLRRP------DEYKAVE 352
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 203 IVSEDLAFLQYTGGTTGVAKGAMLTHRNML-------ANLE-QVNATY----------GPLLHPGKELVITALPLYHIFA 264
Cdd:PLN03052 353 QPVEAFTNILFSSGTTGEPKAIPWTQLTPLraaadawAHLDiRKGDIVcwptnlgwmmGPWLVYASLLNGATLALYNGSP 432
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 265 LTMNCLLFIELGGQNVLITnprdIPGLVKelakypftamTGVNTlfNALLNnkefqqLDFSTLHL--SAGGGMPVQQAVa 342
Cdd:PLN03052 433 LGRGFAKFVQDAKVTMLGT----VPSIVK----------TWKNT--NCMAG------LDWSSIRCfgSTGEASSVDDYL- 489
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 343 erWVKLTGQY--LLEGYGLTECAPlvsvnphdiDYHSGSIGLP-------VPSTEAKLV--DDEDNEVPHGEP--GElCV 409
Cdd:PLN03052 490 --WLMSRAGYkpIIEYCGGTELGG---------GFVTGSLLQPqafaafsTPAMGCKLFilDDSGNPYPDDAPctGE-LA 557
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 410 RGPQvMLG-------------YWQ-RPDATDEIIKDgwlHtGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PLN03052 558 LFPL-MFGasstllnadhykvYFKgMPVFNGKILRR---H-GDIFERTSGGYYRAHGRADDTMNLGGIKVSSVEIERVCN 632
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 476 Q-HSGVLEVAAVGVPSGSSG-EAVKIFVVKKDPSLTEDAL----ITFCR---RQLTG-YKVPKLVEFrDELPKSNVGKIL 545
Cdd:PLN03052 633 AaDESVLETAAIGVPPPGGGpEQLVIAAVLKDPPGSNPDLnelkKIFNSaiqKKLNPlFKVSAVVIV-PSFPRTASNKVM 711

                 ....*..
gi 489956626 546 RRELRDE 552
Cdd:PLN03052 712 RRVLRQQ 718
PLN03051 PLN03051
acyl-activating enzyme; Provisional
92-554 6.39e-07

acyl-activating enzyme; Provisional


Pssm-ID: 215552 [Multi-domain]  Cd Length: 499  Bit Score: 52.13  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  92 FGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI-----VIVSNFAHTL-EKVVEKTQVKHVILTRMGDQLSTAkgtLVN 165
Cdd:PLN03051  12 LAIVLAGCVVVSVADSFSAKEIATRLDISGAKGVftqdvVLRGGRALPLySKVVEAAPAKAIVLPAAGEPVAVP---LRE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 166 FVVKYVKRLVPKYHLPDAisfrRALHagYRMQYVKPEIVSEDLaflqYTGGTTGVAKGAMLTHRNML-------ANLE-Q 237
Cdd:PLN03051  89 QDLSWCDFLGVAAAQGSV----GGNE--YSPVYAPVESVTNIL----FSSGTTGEPKAIPWTHLSPLrcasdgwAHMDiQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 238 VNATY----------GPLLHPGKELVITALPLYHIFALTMNCLLFIELGGQNVLITnprdIPGLVKELAKYPFTAMTGVN 307
Cdd:PLN03051 159 PGDVVcwptnlgwmmGPWLLYSAFLNGATLALYGGAPLGRGFGKFVQDAGVTVLGL----VPSIVKAWRHTGAFAMEGLD 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 308 -TLFNALLNNKEFQQLDfSTLHLSAGGGM--PVQQAVAErwVKLTGQYLLeGYGLTECAPlvsvnphdidyhsGSIGLPV 384
Cdd:PLN03051 235 wSKLRVFASTGEASAVD-DVLWLSSVRGYykPVIEYCGG--TELASGYIS-STLLQPQAP-------------GAFSTAS 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 385 PSTEAKLVDDEDNEVPHGEP--GELCVRGPqvMLGYWQR--PDATDEIIKDG---WLHT-------GDIAVMDDEGFLRI 450
Cdd:PLN03051 298 LGTRFVLLNDNGVPYPDDQPcvGEVALAPP--MLGASDRllNADHDKVYYKGmpmYGSKgmplrrhGDIMKRTPGGYFCV 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 451 VDRKKDMILVSGFNVYPNEIEDVVMQ-HSGVLEVAAVGV-PSGSSGEAVKIFVVKKDPSLT-----EDALITFCRRQLTG 523
Cdd:PLN03051 376 QGRADDTMNLGGIKTSSVEIERACDRaVAGIAETAAVGVaPPDGGPELLVIFLVLGEEKKGfdqarPEALQKKFQEAIQT 455
                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 489956626 524 -----YKVPKlVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PLN03051 456 nlnplFKVSR-VKIVPELPRNASNKLLRRVLRDQLK 490
ac_ac_CoA_syn TIGR01217
acetoacetyl-CoA synthase; This enzyme catalyzes the first step of the mevalonate pathway of ...
30-560 1.48e-06

acetoacetyl-CoA synthase; This enzyme catalyzes the first step of the mevalonate pathway of IPP biosynthesis. Most bacteria do not use this pathway, but rather the deoxyxylulose pathway. [Central intermediary metabolism, Other]


Pssm-ID: 273507 [Multi-domain]  Cd Length: 652  Bit Score: 51.03  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626   30 EHSVRRYADQPAFVNMGEV-----MTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:TIGR01217  91 ENLLRAAGTEPALLYVDEThepapVTWAELRRQVASLAAALRA-LGVRPGDRVSGYLPNIPQAVVAMLATASVGAIWSSC 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  105 NPLYTPRELEHQLNDSGAAAIVIVSNFAHTlekvvEKTQVKHVILTRMGDQLSTAKGTLVNFVVKYVKRLVPKyhLPDAI 184
Cdd:TIGR01217 170 SPDFGARGVLDRFQQIEPKLLFTVDGYRYN-----GKEHDRRDKVAEVRKELPTLRAVVHIPYLGPRETEAPK--IDGAL 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  185 sFRRALHAGYRmqyvKPEIVSEDLAF-----LQYTGGTTGVAKgAMlthrnmlanleqVNATYGPLLHPGKELVITA--- 256
Cdd:TIGR01217 243 -DLEDFTAAAQ----AAELVFEQLPFdhplwILFSSGTTGLPK-CI------------VHSAGGTLVQHLKEHGLHCdlg 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  257 ----LPLYHIFALTM-NCLLFIELGGQNVLITNPRdiPGLVKELAKYPFTAMTGVnTLFNA------LLNNKEF---QQL 322
Cdd:TIGR01217 305 pgdrLFYYTTTGWMMwNWLVSGLATGATLVLYDGS--PGFPATNVLWDIAERTGA-TLFGTsakyvmACRKAGVhpaRTH 381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  323 DFSTLHLSAGGGMPVqQAVAERWV----KLTGQYLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTEAKLVDDEDNE 398
Cdd:TIGR01217 382 DLSALQCVASTGSPL-PPDGFRWVydeiKADVWLASISGGTDICSCFAGANP-TLPVHIGEIQAPGLGTAVQSWDPEGKP 459
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  399 VpHGEPGEL-CVRG-PQVMLGYWQRPDATD------EIIKDGWLHtGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEI 470
Cdd:TIGR01217 460 V-TGEVGELvCTNPmPSMPIRFWNDPDGSKyrdayfDTYPGVWRH-GDWITLTPRGGIVIHGRSDSTLNPQGVRMGSAEI 537
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  471 EDVVMQHSGVLEVAAVGVPSGSSGEAVKIFV-----VKKDPSLTeDALITFCRRQLTGYKVPKLVEFRDELPKSNVGKIL 545
Cdd:TIGR01217 538 YNAVERLDEVRESLCIGQEQPDGGYRVVLFVhlapgATLDDALL-DRIKRTIRAGLSPRHVPDEIIEVPGIPHTLTGKRV 616
                         570
                  ....*....|....*.
gi 489956626  546 RRELRDEARAK-VDNK 560
Cdd:TIGR01217 617 EVAVKRVLQGTpVDNP 632
PRK07868 PRK07868
acyl-CoA synthetase; Validated
276-539 1.93e-06

acyl-CoA synthetase; Validated


Pssm-ID: 236121 [Multi-domain]  Cd Length: 994  Bit Score: 50.87  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 276 GGQNVLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqqavAERWVKLTGQY--- 352
Cdd:PRK07868 671 GGSRIALSRGLDPDRFVQEVRQYGVTVVSYTWAMLREVVDDPAFVLHGNHPVRLFIGSGMP-----TGLWERVVEAFapa 745
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 353 -LLEGYGLTEC-APLVSVNPHDIdyhsGSIGLPVPST-----------EAKLVDDEDNEVPHGEPGElcvrgPQVMLGYW 419
Cdd:PRK07868 746 hVVEFFATTDGqAVLANVSGAKI----GSKGRPLPGAgrvelaaydpeHDLILEDDRGFVRRAEVNE-----VGVLLARA 816
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 420 QRP-DATDEIIK------DGWLHTGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAVGVPSGS 492
Cdd:PRK07868 817 RGPiDPTASVKRgvfapaDTWISTEYLFRRDDDGDYWLVDRRGSVIRTARGPVYTEPVTDALGRIGGVDLAVTYGVEVGG 896
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489956626 493 SGEAVKIFVVKKDPSLTEDALITFCRRQLTGYKvPKLVEFRDELPKS 539
Cdd:PRK07868 897 RQLAVAAVTLRPGAAITAADLTEALASLPVGLG-PDIVHVVPEIPLS 942
PaaK cd05913
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic ...
392-480 4.50e-06

Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.


Pssm-ID: 341239 [Multi-domain]  Cd Length: 425  Bit Score: 49.16  E-value: 4.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 392 VDDEDNE-VPHGEPGE-----LCVRGPQVmLGYWqrpdatdeiikdgwlhTGDIAVMDDEG---------FLRIVDRKKD 456
Cdd:cd05913  262 IDPETGEpVPPGEVGElvfttLTKEAMPL-IRYR----------------TRDITRLLPGPcpcgrthrrIDRITGRSDD 324
                         90       100
                 ....*....|....*....|....
gi 489956626 457 MILVSGFNVYPNEIEDVVMQHSGV 480
Cdd:cd05913  325 MLIIRGVNVFPSQIEDVLLKIPGL 348
AACS cd05943
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...
50-545 5.02e-06

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.


Pssm-ID: 341265 [Multi-domain]  Cd Length: 629  Bit Score: 49.19  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626  50 TFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPlytprelehqlnDSGAAAIV--- 126
Cdd:cd05943  100 TWAELRRRVARLAAALRA-LGVKPGDRVAGYLPNIPEAVVAMLATASIGAIWSSCSP------------DFGVPGVLdrf 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 127 --IVSNFAHTLEKVVEKTQVKHVI--LTRMGDQLSTAKGTLvnfVVKYvkrlVPKYHLPDAISFRRALH-AGYRMQYVKP 201
Cdd:cd05943  167 gqIEPKVLFAVDAYTYNGKRHDVRekVAELVKGLPSLLAVV---VVPY----TVAAGQPDLSKIAKALTlEDFLATGAAG 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 202 EIVSEDLAF-----LQYTGGTTGVAKGAMLTHRNMLanLEQVNATygpLLH----PGKELvitalplyHIFALTM----N 268
Cdd:cd05943  240 ELEFEPLPFdhplyILYSSGTTGLPKCIVHGAGGTL--LQHLKEH---ILHcdlrPGDRL--------FYYTTCGwmmwN 306
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 269 CLL-FIELGGQNVLITNPrdiPGLVKELAKYPFTAMTGVNTL-----FNALLNNKEFQQ---LDFSTLH--LSAGGGMPV 337
Cdd:cd05943  307 WLVsGLAVGATIVLYDGS---PFYPDTNALWDLADEEGITVFgtsakYLDALEKAGLKPaetHDLSSLRtiLSTGSPLKP 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 338 QQAvaeRWV--KLTGQYLLEGY-GLTE-CAPLVSVNPhDIDYHSGSIGLPVPSTEAKLVDDEDNEVPhGEPGEL-CVRG- 411
Cdd:cd05943  384 ESF---DYVydHIKPDVLLASIsGGTDiISCFVGGNP-LLPVYRGEIQCRGLGMAVEAFDEEGKPVW-GEKGELvCTKPf 458
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 412 PQVMLGYWQRPDATD------EIIKDGWLHtGDIAVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAA 485
Cdd:cd05943  459 PSMPVGFWNDPDGSRyraayfAKYPGVWAH-GDWIEITPRGGVVILGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLV 537
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489956626 486 VGVPSGSSGEAVKIFVVKKDPSLTEDALI----TFCRRQLTGYKVPKLVEFRDELPKSNVGKIL 545
Cdd:cd05943  538 VGQEWKDGDERVILFVKLREGVELDDELRkrirSTIRSALSPRHVPAKIIAVPDIPRTLSGKKV 601
PRK03584 PRK03584
acetoacetate--CoA ligase;
30-84 1.07e-05

acetoacetate--CoA ligase;


Pssm-ID: 235134 [Multi-domain]  Cd Length: 655  Bit Score: 48.25  E-value: 1.07e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489956626  30 EHSVR-RYADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLQKGDRVALMMPNL 84
Cdd:PRK03584  90 ENLLRhRRDDRPAIIFRGEdgprrELSWAELRRQVAALAAALRA-LGVGPGDRVAAYLPNI 149
A_NRPS_acs4 cd17654
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...
206-549 2.44e-05

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341309 [Multi-domain]  Cd Length: 449  Bit Score: 47.08  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVNATYGplLHPGKELVITALPLYHIFALTmnclLFIELGGQNVLITNP 285
Cdd:cd17654  118 ECLAYVIHTSGTTGTPKIVAVPHKCILPNIQHFRSLFN--ITSEDILFLTSPLTFDPSVVE----IFLSLSSGATLLIVP 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 286 RDIPGLVKELAKYPF-----TAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMP-VQQAVAERWV-KLTGQYLLEG 356
Cdd:cd17654  192 TSVKVLPSKLADILFkrhriTVLQATPTLFRRFGSqsIKSTVLSATSSLRVLALGGEPfPSLVILSSWRgKGNRTRIFNI 271
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 357 YGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDEDNEVPHGEPGELCVRGpQVMLGYWQRPDATdeiikdgWLHT 436
Cdd:cd17654  272 YGITEVSCWALAYKVPEEDSPVQLGSPLLGTVIEVRDQNGSEGTGQVFLGGLNRV-CILDDEVTVPKGT-------MRAT 343
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489956626 437 GDIaVMDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVLEVAAvgvpSGSSGEAVKIFVVkkdpSLTEDALItF 516
Cdd:cd17654  344 GDF-VTVKDGELFFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAV----TLSDQQRLIAFIV----GESSSSRI-H 413
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 489956626 517 CRRQLTG---YKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17654  414 KELQLTLlssHAIPDTFVQIDKLPLTSHGKVDKSEL 449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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