|
Name |
Accession |
Description |
Interval |
E-value |
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-394 |
0e+00 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 565.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 1 MKKQRNVNLLLMLVLLVAVGQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGM 80
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 81 SIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWS 160
Cdd:PRK11652 81 SIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 161 WRACYAFLLVLCIIVTFSMGRWMPETRPKDAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGL 240
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 241 SSMVVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVISCLLAGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLA 320
Cdd:PRK11652 241 SSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGMLFPLA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489957763 321 TSGAMEPFPFLAGTAGALVGGLQNIGSGALAWLSAMMPQTGQASLGLLMTLMGLLILLCWLPLASRVSHHEQPV 394
Cdd:PRK11652 321 TSGAMEPFPYLAGTAGALLGGLQNIGSGLAALLSAMLPQTGQFSLGLLMTLMGLLILLCWLPLATRMSHQGQPV 394
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-362 |
1.61e-82 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 257.12 E-value: 1.61e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVL 99
Cdd:cd17320 11 GPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 100 IAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSM 179
Cdd:cd17320 91 LIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 GRWMPETRPKDAPRT---KLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAA 256
Cdd:cd17320 171 LLFLPETLPEEKRKPllsSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 257 FFGAWFAGRPNKRFS--TLMWQSVISCLLAGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGT 334
Cdd:cd17320 251 ILGSLLNGRLVRRFGprRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGT 330
|
330 340
....*....|....*....|....*...
gi 489957763 335 AGALVGGLQNIGSGALAWLSAMMPQTGQ 362
Cdd:cd17320 331 ASALLGFLQFLIGALAGALVGLLPNGTA 358
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-343 |
8.82e-39 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 142.91 E-value: 8.82e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVL 99
Cdd:TIGR00710 17 GPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 100 IAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSM 179
Cdd:TIGR00710 97 LVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 GRWMPETRPKDAPR--TKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAF 257
Cdd:TIGR00710 177 FFILPETLPYEARIqiSTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 258 FGAWFAGRPNKRFSTL-MWQSVISCLLAGLM-MWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTA 335
Cdd:TIGR00710 257 FGGFLNGRFIKKWGAKsLLRMGLILFAVSAVlLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTA 336
|
....*...
gi 489957763 336 GALVGGLQ 343
Cdd:TIGR00710 337 SALFGTLR 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-349 |
4.90e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.41 E-value: 4.90e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:COG2814 24 LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGR 181
Cdd:COG2814 104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 182 WMPETRPkdAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFGAW 261
Cdd:COG2814 184 LLPESRP--AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 262 FAGRPNKRFStLMWQSVISCLLAGLMMWIPGLFDvmSVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVG 340
Cdd:COG2814 262 LAGRLADRFG-RRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYN 338
|
....*....
gi 489957763 341 GLQNIGSGA 349
Cdd:COG2814 339 SAFFLGGPL 347
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-360 |
1.37e-29 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 117.71 E-value: 1.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 27 YIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQ 106
Cdd:PRK11102 10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 107 GVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPET 186
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 187 RPKDApRTKL-----IASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFGAW 261
Cdd:PRK11102 170 LPKER-RQPFhlrttIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFLFVMTI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 262 FAGRPNKRF-STLMWQSVISC-LLAGLMMWIPGLFDVmSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALV 339
Cdd:PRK11102 249 INSRFVRRVgALNMLRFGLWIqFIMGIWLVVSALLDL-GFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMAGTASSLA 327
|
330 340
....*....|....*....|..
gi 489957763 340 GGLQnIGSGALAW-LSAMMPQT 360
Cdd:PRK11102 328 GTLR-FGIGAIVGaLLSLAPFT 348
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-186 |
1.10e-28 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 108.89 E-value: 1.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 52 YLLTYGVSQLVYGPLS----DRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMYQG 127
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 489957763 128 TQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPET 186
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-357 |
1.24e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 109.18 E-value: 1.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 28 IPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQG 107
Cdd:cd17324 19 QGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 108 VGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPETR 187
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 188 PKDAPRTKLIASYKTLFGNGS-FTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIpAAFFGAWFAGRP 266
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRlRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV-AGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 267 NKRFSTLMWqSVISCLLAGLMMWIPGLFdvMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIG 346
Cdd:cd17324 258 ADRGGRRAL-LIALLLLAAALLLLTLLG--PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLG 334
|
330
....*....|.
gi 489957763 347 SGALAWLSAMM 357
Cdd:cd17324 335 GALGAALGGLV 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-349 |
2.10e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.02 E-value: 2.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIA-DMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLI 100
Cdd:pfam07690 10 LGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 101 AASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMG 180
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 181 RWMPET-----RPKDAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGA--GLGLSSMVVSILFILPI 253
Cdd:pfam07690 170 LPRPPPeskrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLglSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 254 PAAFFGAWFAGRPNKRFSTLMwqsVISCLLAGLMMWIPGLFDVMSVWTLLIpAALFFFGAGMLFPLATSGAMEPFPF-LA 332
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLL---ALLLLILAALGLLLLSLTLSSLWLLLA-LLLLGFGFGLVFPALNALVSDLAPKeER 325
|
330
....*....|....*..
gi 489957763 333 GTAGALVGGLQNIGSGA 349
Cdd:pfam07690 326 GTASGLYNTAGSLGGAL 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-357 |
8.74e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 92.63 E-value: 8.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:cd17474 13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTvWSWRACYAFLLVLCIIVTFSMGR 181
Cdd:cd17474 93 GRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 182 WMPET-RPKDAPRTKLIASYKTLFGNGSFtcyLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSIL-FILPIPAAFF- 258
Cdd:cd17474 172 LLPEPkEKAKSSSATKLRDLKKALRGRGL---LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIgLLFAGWSVLLa 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 259 -GAWFAGRPNKRFSTLMWQSVISCLLAGLMMWIPGLFDvmSVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAG 336
Cdd:cd17474 249 lGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP--SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPeEERGTAS 326
|
330 340
....*....|....*....|.
gi 489957763 337 ALVGGLQNIGSGALAWLSAMM 357
Cdd:cd17474 327 SLYNFVRFLGQAVGPLLFGLL 347
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-348 |
8.80e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 8.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVL 99
Cdd:cd17321 8 AALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 100 IAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSM 179
Cdd:cd17321 88 IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 grwmpetrpkdapRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEAcsgvllgaglglssmVVSILFILPIPAA-FF 258
Cdd:cd17321 168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSP---------------LQAGLALLPLALAmLV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 259 GAWFAGRPNKRFSTLmWQSVISCLLAGL-MMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGTAG 336
Cdd:cd17321 220 AAPLAGRLADRFGPR-LVLVAGLLLTAVgLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKeKAGAAS 298
|
330
....*....|..
gi 489957763 337 ALVGGLQNIGSG 348
Cdd:cd17321 299 GILNTARQLGGA 310
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-290 |
9.09e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 88.71 E-value: 9.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:COG0477 28 LDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFsMGR 181
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV-LRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 182 WMPETRPKDAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFGAW 261
Cdd:COG0477 187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
250 260
....*....|....*....|....*....
gi 489957763 262 FAGRPNKRFSTLMWQSVISCLLAGLMMWI 290
Cdd:COG0477 267 LLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-322 |
5.07e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.63 E-value: 5.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGR 181
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 182 WMPETRPKDAPRT----KLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAF 257
Cdd:cd17325 170 LLPEPRPPPNKRAvsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489957763 258 FGAWFAGRPNKRFSTLMWqSVISCLLAGLMMWIPGLFDvmSVWTLLIPAALFFFGAGMLFPLATS 322
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLA 311
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-359 |
7.65e-19 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 87.26 E-value: 7.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVL 99
Cdd:PRK11043 18 GFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 100 IAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSM 179
Cdd:PRK11043 98 LVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 GRWMPETRPKDAPRTKLiaSYKTLFGNGSFtcyllmliggLAGIAVFEACSgvllgaglglssmvvsilfilpipAAFFg 259
Cdd:PRK11043 178 LRLKPSKKARKQSQDAL--TFKQLLKSKTY----------LGNVLIFAACS------------------------AAFF- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 260 AWFAGRP----NKRFS-----------TLMW----------------QSVISCLLAG-----LMMWIPGLFDVMSVWTLL 303
Cdd:PRK11043 221 AWLTGSPfileQMGYSpadiglsyvpqTIAFlvggygcraalqkwggEQLLPWLLVLfavsvIAIWLASLLSHPSLVPLL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489957763 304 IPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQ-NIGSGALAWLSAMMPQ 359
Cdd:PRK11043 301 IPFCVMAAANGAIYPIVVAQALRPFPQATGKAAALQNTLQlGLCFLASLLVSALIST 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-357 |
1.25e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.46 E-value: 1.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 30 AIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVG 109
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 110 TGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMpetrpk 189
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLL------ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 190 daprtkLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEAcsgvllgaglglsSMVVSILFILPIPAAFFGAWFAGRPNKR 269
Cdd:COG2271 186 ------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA-------------GLLLSLPFLAGIVGSLLGGWLSDRLGRR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 270 FSTLMwqsVISCLLAGLMMWIPGLFDvmSVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSG 348
Cdd:COG2271 247 RKLVL---AIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGA 321
|
....*....
gi 489957763 349 ALAWLSAMM 357
Cdd:COG2271 322 LGPLLVGYL 330
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
20-357 |
2.59e-16 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 79.54 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVL 99
Cdd:cd17503 8 AILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 100 IAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSm 179
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 grwmpetrpkdAPRTKLiasykTLFGNGSFTcyLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMV-VSILFILPIP-AAF 257
Cdd:cd17503 167 -----------APLLDL-----RLFKDRNFT--LGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAfESGLVLAPGGlASA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 258 FGAWFAGRPNKRFSTLMWQSVISCLLAGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLF-PLATSGAMEPFPFLAGTAG 336
Cdd:cd17503 229 ILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFmPLNTLALNSLPPEQIGDAT 308
|
330 340
....*....|....*....|..
gi 489957763 337 ALVGGLQNIGSG-ALAWLSAMM 357
Cdd:cd17503 309 ALFNTIRQLGGSiGTALLATLL 330
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
20-357 |
7.96e-16 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 78.00 E-value: 7.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVL 99
Cdd:cd17323 11 VTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAML 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 100 IAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSM 179
Cdd:cd17323 91 IILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 GRWMPETRpkdaprtkLIASYkTLFGNGSFTCYLLMLIGGLAGIAVFEacsgvllgaglglsSMVVSILFILPIPAAFFG 259
Cdd:cd17323 171 FLFLPIVL--------LLGLY-VGLVYAILYLFLTAFPYVFGEVYGFS--------------PGEVGLMYLPIGIGALIG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 260 AWFAGRPNKRF--------------STLMWQSVISCLL--AGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATSG 323
Cdd:cd17323 228 SIIGGRLSDYYyrrlkkknggkpepEARLPPAFIGAFLfpIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTY 307
|
330 340 350
....*....|....*....|....*....|....
gi 489957763 324 AMEPFPFLAGTAGALVGGLQNIGSGALAWLSAMM 357
Cdd:cd17323 308 LVDSYPKYAASALAANTLVRSIFAAIFPLFAQPM 341
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-357 |
1.10e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.85 E-value: 1.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDT--VWSWRACYAFLLVLCIIVTFSM 179
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 GRWMPETRPKDAPRTK------LIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPI 253
Cdd:cd06174 170 LLVVPDPPESARAKNEeassksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 254 PAAFFGAWFAGRPNKRFSTLMWQSVISCLLAGLMMWIPGLFDVMSVWTLLipAALFFFGAGMLFPLATSGAMEPFPF-LA 332
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL--LLLLGFGLGGLLPLSFALIAELFPPeIR 327
|
330 340
....*....|....*....|....*
gi 489957763 333 GTAGALVGGLQNIGSGALAWLSAMM 357
Cdd:cd06174 328 GTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
29-223 |
1.25e-15 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 77.67 E-value: 1.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 29 PAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGV 108
Cdd:PRK15402 34 PGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 109 GTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPET-- 186
Cdd:PRK15402 114 GLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETag 193
|
170 180 190
....*....|....*....|....*....|....*...
gi 489957763 187 -RPKDAPRTKLIASYKTLFGNGSFTCYLLMLigGLAGI 223
Cdd:PRK15402 194 rVGEKLSLKELGRDYKLVLKNRRFVAGALAL--GLVSL 229
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
26-355 |
1.83e-14 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 74.29 E-value: 1.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 26 IYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASAL 105
Cdd:PRK10473 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 106 QGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPE 185
Cdd:PRK10473 101 QGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 186 TRPKDAPRTKLIASYKT-LFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLS----SMVVSILFILPIPAAFFGA 260
Cdd:PRK10473 181 TRPARAPAASSKPRENSeSLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSrgeyAIIMALTAGVSMTVSFSTP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 261 WFAGRPNKRfsTLMWQSVISCLLAGLMMWIPGLFDVmsvwtLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVG 340
Cdd:PRK10473 261 FALGIFKPR--TLMLTSQVLFLAAGITLALSPSHAV-----SLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLG 333
|
330
....*....|....*
gi 489957763 341 GLQNIGSGALAWLSA 355
Cdd:PRK10473 334 IAQVCGSSLWIWLAA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-357 |
2.36e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 73.76 E-value: 2.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:COG2223 19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGR 181
Cdd:COG2223 99 LGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 182 WMPET-RPKDAPRTKLIASYKTLFGNGSF-TCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAF-- 257
Cdd:COG2223 179 FLRDPpAGAAAAAKASLRDQLEALRDPRFwLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALgr 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 258 -FGAWFAGRPNKRfSTLMWQSVISCLLAGLMMWIPGlfdvmSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:COG2223 259 pLGGWLSDRIGGR-RVLLIVFALMALGLLLLALALG-----SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTkNAGAV 332
|
330 340
....*....|....*....|..
gi 489957763 336 GALVGGLQNIGSGALAWLSAMM 357
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGAL 354
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-165 |
2.24e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.51 E-value: 2.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 28 IPAIADMAKDLSvregAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQG 107
Cdd:cd17502 19 LPTIVAEFGGLS----LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQG 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 489957763 108 VGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACY 165
Cdd:cd17502 95 IGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF 152
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
28-186 |
1.19e-09 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 59.45 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 28 IPAIADMAKDLSVREGAVQSVMAAYLltygVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQG 107
Cdd:PRK15403 40 INVVRDFNADVSLAPASVSLYLAGGM----ALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQG 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489957763 108 VGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPET 186
Cdd:PRK15403 116 TSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
34-320 |
1.64e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.78 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 34 MAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVG 113
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 114 GVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLdTVWSWRACYAFLLVLCIIVTFSMGRWMPETRPKDAPR 193
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 194 TK--LIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFGAWFAGRPNKRFS 271
Cdd:cd17329 185 EKteILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489957763 272 TLMWQSVISCLLAGLMMWIPGlfdVMSVWTLLIPAALFFFGAGMLFPLA 320
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAF---ANTLAVLILAMIVLTLGEMLVFPAV 310
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-322 |
2.54e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.76 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 43 GAVQSVMAAYLLTYGVSQLVYGPLSDRVG-----RRPVILVGMSIFMVATMIAITTHSLT------VLIAASALQGVGTG 111
Cdd:COG2211 46 ALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 112 VGGVMARTLPRDMYQGTQLR-HANSLLNMGILVSPLLAPLIGGLL------DTVWSWRACYAFLLVLCIIVTFSMGRWMP 184
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERtRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 185 ETRPKDAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFGAWFAG 264
Cdd:COG2211 206 ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489957763 265 RPNKRFSTLMWqSVISCLLAGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATS 322
Cdd:COG2211 286 RLAKRFGKKKA-FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-348 |
2.99e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 57.97 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 21 QMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLI 100
Cdd:cd17504 9 MLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 101 AASALQgVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSmg 180
Cdd:cd17504 89 AGRALQ-GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL-- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 181 rwmpetrpkdAP--RTKLIASYKTLFGNGSftcYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFF 258
Cdd:cd17504 166 ----------VPliDLRLLRRRNVLLANIT---ALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 259 GAWFAGRPNKRFS--TLMWQSVISCLLAGLMMwipgLFDVMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:cd17504 233 AGPLAGRLIARVGprRVLLIGLVISAVGLLLL----ALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPdRTGIA 308
|
330
....*....|...
gi 489957763 336 GALVGGLQNIGSG 348
Cdd:cd17504 309 TGMNTVLRTIGSA 321
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-322 |
1.70e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 55.68 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 49 MAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMArtLPRDMYQGT 128
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMA--LLADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 129 QLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACY---AFLLVLCIIVTFSMgrwMPETRPKDAPRTKLIASYKTLFG 205
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFlitAILSLVSLLILLFF---VPDPPKIVQISEKEKKKLKKLLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 206 NGSFTC-YLLMLIGGLAGIAVFEACSGVLLGAGLGLSSM------VVSILFILPIPAAFFGawfagrpNKRFStlMWQSV 278
Cdd:cd17472 193 NKRLLRlDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLwkvylpAILIGFILMVPFVIYA-------EKKGK--MKQVF 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489957763 279 ISCLLAGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATS 322
Cdd:cd17472 264 VSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPS 307
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-318 |
2.39e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 26 IYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASAL 105
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 106 QGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIvTFSMGRWMPE 185
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-ALLLVFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 186 TRPKDAPRTKLIASYKTLFGNGSFT--CYLLMLIG-GLAGIAVFEACSGVLLGAGLGLSSMVVSILFILpIPAAFFGAWF 262
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLppALILFLASiAYGAISTFLPLYAAERGISNAGLFFTVYAIALL-LSRPFSGKLS 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 489957763 263 AGRPNKRFstlmwqSVISCLLAGLMMWIpgLFDVMSVWTLLIPAALFFFGAGMLFP 318
Cdd:cd17489 252 DRKGPKTV------IIPGLLLLALGLLL--LSFAGSPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-330 |
3.91e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKD-LSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLI 100
Cdd:cd17473 13 MAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 101 AASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVwSWRacYAFLL-VLCIIVTFSM 179
Cdd:cd17473 93 ASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWR--APFLVyLLALPVLILV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 GRWMPETRPKDAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFG 259
Cdd:cd17473 170 LLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489957763 260 AWFAGRPNKRFSTLMWQSVISCLLAG--LMMWIPGlfdvmSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF 330
Cdd:cd17473 250 ALLFGRLKRRLGKRRLLAIGFALMALgfLLLALAS-----GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPP 317
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
51-177 |
4.28e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 54.94 E-value: 4.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 51 AYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASAL----QGVGTGVGGVMARTLPRdMYQ 126
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALigigAGTQGLGAAVASELVPN-KYR 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489957763 127 GTqlrhANSLLNMGILVSPLLAPLIGGLL--DTVWSWRACYAFLLVLCIIVTF 177
Cdd:cd06179 119 GL----VQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALI 167
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-353 |
1.14e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.34 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 30 AIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASAL---- 105
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLlgva 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 106 -QGVGTGVGGVMARTLPRDmYQGTqlrhANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMP 184
Cdd:cd17319 105 eAGFFPGAIKALAEWFPAR-ERGR----ATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 185 ETrpkdaprtkliasYKTLFGNGSFTCYLLMLIGGLAGIAVfeacsgvllgAGLGLSSMVVSILFILPIPAAFFGAWFAG 264
Cdd:cd17319 180 QV-------------WGLALGYFGINYALYGLLTWLPTYLK----------QARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 265 RPNKRFSTLMWQSVISCLLAGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGTAGALVGGLQ 343
Cdd:cd17319 237 RLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGG 316
|
330
....*....|
gi 489957763 344 NIGSGALAWL 353
Cdd:cd17319 317 NLGGFVAPLL 326
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-353 |
1.03e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYQGTQlRHANSLLNMGILVSPLLAPLIGGLL---DTVWSWRACYAFLLVLCIIVTFS 178
Cdd:COG0738 102 ALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 179 MGRW-MPETRPKDAPRTKLIASYKTLFGNGSFtcyLLMLIGGLAGIAVFEACSGVLLGAGLGLSSM---VVSILFILPIP 254
Cdd:COG0738 181 FLRSkLPEIEEEEEEAAGSAASLKSLLKNPRL---LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLseaTAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 255 AAFFGAWFAGRPNKRFS---TLMWQSVISCLLAGLMMWIPGLfdvmsvWTLLIPAALFFFGAGMLFPLATSGAMEPFPFL 331
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGpvrLLRLSALLAAVGLLLALLAPGP------WLALIGLALVGLGLSLMFPTIFSLALDGLGKR 331
|
330 340
....*....|....*....|..
gi 489957763 332 AGTAGALVGGLQNIGSGALAWL 353
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPL 353
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
21-347 |
1.13e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.95 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 21 QMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLI 100
Cdd:cd17476 11 QAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 101 AASALQGVGTGVGGVMARTLPRDMYQGTQLRH-ANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVtfsm 179
Cdd:cd17476 91 ICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIV---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 180 grwmpetrpkdaprtkLIASYktLFGNGSFTCYLLMLIGGLAGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAAFFG 259
Cdd:cd17476 167 ----------------AVAAI--FWTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 260 AWFAGR--PNKRFSTLMWQSVISCLLAGLMmwipglFDVMSV----WTLLIPAALFF-FGAGMLFPLAT---SGAMEpfP 329
Cdd:cd17476 229 AITVGFliARLPPSYIMAISMVAFLVGPIL------FATMPVhqtyWAQAFPAMIVApFGMDFSFPAATiiaSNAVP--R 300
|
330
....*....|....*...
gi 489957763 330 FLAGTAGALVGGLQNIGS 347
Cdd:cd17476 301 EYQGLAGSLVNTVVNYGI 318
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
48-187 |
1.16e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.79 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 48 VMAAYLLTYGVSQLVYGPLSDRVGRR--PVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMY 125
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489957763 126 QGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPETR 187
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
22-329 |
1.82e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.45 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYlltyGVSQLVY----GPLSDRVGRR-PVILVGMSIFMVATMIAITTHSL 96
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAY----GISQMLLriplGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 97 TVLIAASALqGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRacYAFLL-----VL 171
Cdd:cd17490 86 WGLLIARFL-SGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMR--APFLLaalagVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 172 CIIVTFSMgrwmPETRPKDAPRTKLIASYKTLFGNGSftcylLMLIGGLAGIAVFEACSGVLLGAGLGLSSM-------- 243
Cdd:cd17490 163 GFILSLFI----KEERREKKPVLTELKELLSVLKDKK-----LLFFSLLAILQQMITFSTTFGFTPLIAKQLgassfqlg 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 244 VVSILFILP-IPAAFFGAWFAGRPNKRFSTLMWQSVISCLLAGLMMWIPGLfdvmsvWTLLIPAALFFFGAGMLFPLATS 322
Cdd:cd17490 234 LLSIIYLLPnALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNL------TLLYLLQALNGFGTGILFPLLMS 307
|
....*..
gi 489957763 323 GAMEPFP 329
Cdd:cd17490 308 LSIEGVP 314
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-182 |
3.42e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 3.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 48 VMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMYQG 127
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 489957763 128 TQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRW 182
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
25-184 |
3.57e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 45.49 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 25 TIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASA 104
Cdd:PRK10504 27 TIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 105 LQGVGTGVGGVMAR-----TLPRDMYQGtqlrhANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSM 179
Cdd:PRK10504 107 LQGVGGAMMVPVGRltvmkIVPREQYMA-----AMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIAT 181
|
....*
gi 489957763 180 GRWMP 184
Cdd:PRK10504 182 LMLMP 186
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-357 |
5.21e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.90 E-value: 5.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 48 VMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTL----PRD 123
Cdd:cd17316 41 LFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYvaefAPS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 124 MYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFsmgrwmpetrpkdAPRTKLIASYKTL 203
Cdd:cd17316 121 KRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALL-------------LRRRTLLLILLWF 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 204 FGNGSFTCYLLMLIGGLAGIAVFeacsgvllgaGLGLSSMVVSILFILPIPAAFFGAWFAGRPNKRfstlmWQSVISCLL 283
Cdd:cd17316 188 FISFGYYGLTTFLPTYLQTVLGL----------SPATSSLYLLLISLGALVGALIAGLLSDRIGRK-----KTLVIGLIL 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489957763 284 AGLMMWIPGLFDVMSVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSGALAWLSAMM 357
Cdd:cd17316 253 SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-346 |
7.22e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 7.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 22 MAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 102 ASALQGVGTGVGGVMARTLPRDMYqGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGR 181
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 182 WMPEtRPKDAPRTKLIASYKTLFGNGSFtcYLLMLIGGL-----AGIAVFEACSGVLLGAGLGLSSMVVSILFILPIPAA 256
Cdd:COG2807 191 LLRR-RPAAAAAAPAAASLRSLWRSPLA--WLLTLFFGLqsllyYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 257 FFGAWFAGRPNKRFSTLMWQSVISCLLAGLMMWIPGlfdvmsvWTLLIPAALFFFGAGMLFPLATSGAMEPFPfLAGTAG 336
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG-------SLPWLWAVLLGLGQGGLFPLALTLIGLRAR-TPAEAA 339
|
330
....*....|
gi 489957763 337 ALVGGLQNIG 346
Cdd:COG2807 340 ALSGMAQSVG 349
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
37-174 |
3.64e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 37 DLSVREGAVqsVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVM 116
Cdd:cd17313 277 GAGVRMGAW--GLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININ 354
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 117 ARTLPRDMY------QGTQLrhanSLLNMGILVSPLLAPLIGGLLD------TVWSWRACYAFLLVLCII 174
Cdd:cd17313 355 PYPLVSDYHsesgrgQGTDT----GLLNLAISLAQILVSLLAGPIIdvkgygTVFPVAAVASFLSLVGAL 420
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-174 |
4.70e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 4.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 35 AKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGG 114
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 115 VMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCII 174
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
23-357 |
5.81e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 5.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 23 AQTIYIPAIADMAKDLSVregaVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAA 102
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAV----ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 103 SALQGVGTGVGGVMARTLPRDMYQ-GTQLRHANSLLNMGI-LVSPLLAPLIGGLLDTvWSWRACY----AFLLVLCIIVT 176
Cdd:cd17355 98 WGLLGGGGAGTLAAVAFATVAAWWfERRRGLALGILTAGGgLGSLVFLPLGAALIEA-FGWRTALlvlaLLALLVLVPVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 177 FSMGRWMPETRPKDAPRTKLIASYKTLFGNGSFTCYLLMLIG------GLAGIAVFEACSGVLLGAGLGLSSMVVSILFI 250
Cdd:cd17355 177 LLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAfflcgfAVVGLIVHLVPYLADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 251 LPIPAAFFGAWFAGRPNKRfstlmWQSVISCLLAGLMMWIPGLFDVMSVWTLLIpAALFFFGAGMLFPLATSGAMEPFP- 329
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPR-----RLLAASYALRALGLALLLLLPFPPLALLLF-AALFGLGWGATVPLTAALAARYFGa 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489957763 330 --------------FLAGTAGALVGGLQN--IGSGALAWLSAMM 357
Cdd:cd17355 331 rsygtlfglvfaphQLGSALGPWLGGLLYdrTGSYTAAWALAVA 374
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-355 |
9.46e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 9.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 64 GPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMYQGTQ---LRHANSLLNMG 140
Cdd:cd17333 52 GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSatrLNVLHGFFGLG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 141 ILVSPLlapLIGGLLDTVWSWRACY------AFLLVLCIIVTFSMgrWMPETRPKDAPRTKLIASYKTLFGN---GSFTC 211
Cdd:cd17333 132 ALIGPL---IATSLLTSELSWSWAYliigliYLLLAILILLTLFP--ELPSARNPQQSVGAFSASASRLLRNpsiILGAL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 212 YLLMLIGGLAGIAVF-EACSGVLLGAGLGLSSMVVSILFILPIPAAFFGAWFAGRpnKRFSTLMWQSVISCLLAGLMMWI 290
Cdd:cd17333 207 ALFLYVGAETAFSSWvPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRR--IKPHTLLVLSGSGALLGLLILLL 284
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489957763 291 PGLFDVMSVWTLLIpaalfFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGALAWLSA 355
Cdd:cd17333 285 APTLVVGLVATALL-----GLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-185 |
1.26e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.80 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 34 MAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGM---SIFMVATMIAITTHSLTVL--IAASALQGV 108
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIllfSVFTLLCALATNVTQLLILrfLAGLGLGGL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489957763 109 GTGVGGVMARTLPrDMYQGTQLrhanSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRWMPE 185
Cdd:TIGR00895 123 MPNLNALVSEYAP-KRFRGTAV----GLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPE 194
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-356 |
1.68e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.05 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 48 VMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMYQG 127
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 128 TQLRHANSLLNMGILVS-PLLAPLIGGLLDTVWSWRACYAFLLVLCIIVTF----------------SMGRWMPETRPKD 190
Cdd:TIGR00881 115 SERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLicflllrdspqscglpPAEEMPNEEPDGD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 191 AP-----RTKLIASYKTLFGN----GSFTCYLL---MLIGGLAGIAVFeacsgvlLGAGLGLSSMVVSILFILPIPAAFF 258
Cdd:TIGR00881 195 AEkkeeeLTKKQIFLQYVLLNkvlwYISLGYVFvyvVRTGILDWSPLY-------LTQEKGFSKEKASWAFTLYELGGLV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 259 GAWFAG------RPNKRFSTLM-WQSVISCLLAGLMMwIPGLFDVMsVWTLLIPAALFFFGAGMLFPLATSGAMepFPFL 331
Cdd:TIGR00881 268 GTLLAGwlsdklFNGRRGPLAVfFMALIIVSLLVYWL-NPAANPLM-DLICLFALGFLVYGPQMLIGVIASELA--PKKA 343
|
330 340
....*....|....*....|....*
gi 489957763 332 AGTAGALVGGLQNIGSGALAWLSAM 356
Cdd:TIGR00881 344 AGTAAGFVGFFAYLGGILAGLPLGY 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-325 |
2.37e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 20 GQMAQTIYIPAIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAI-----TTH 94
Cdd:cd06173 11 SALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAllallGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 95 SLTVLIAASALQGVGTGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACY---AFLLVL 171
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFainALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 172 CIIVTFSMGRWMPETRPKDAPRTKLIASYKTLFGNGSFTCYLLMLIGGLAG--IAVFEACSGVLLGAGLGLSSMVVSILF 249
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAllGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489957763 250 ILPIPAAFFGAWFAGRPNKRFSTLMWqSVISCLLAGLMMWIPGLfdvmSVWTLLIPAALFFFGAGMLFPLATSGAM 325
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRL-LLIGALLLGLALLVLGL----SPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
51-211 |
3.33e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.14 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 51 AYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVGTGVGGVMARTLPRDMYQGTQL 130
Cdd:cd17328 42 VFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 131 RHANSLLNMGILVSPLLAPLIGGLLDTVW-SWRACYAFLLVLCIIVTFSMGRWMPETRPKDAPR--------TKLIASYK 201
Cdd:cd17328 122 TRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGgvmakstaTSFLADLK 201
|
170
....*....|
gi 489957763 202 TLFGNGSFTC 211
Cdd:cd17328 202 ALAKNPSFIL 211
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
57-182 |
5.19e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.88 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 57 GVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALqgvgTGVGGVMARTLPrdMYQGTQLRHANSL 136
Cdd:pfam06609 92 AVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTL----LGVAAGPAGASP--LFIGELMSNKTKF 165
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 489957763 137 LNMGILVSPLLA-----PLIGGLLDTVWSWRACYAFLLVLCIIVTFSMGRW 182
Cdd:pfam06609 166 LGLLIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIW 216
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
58-101 |
8.95e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.02 E-value: 8.95e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 489957763 58 VSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIA 101
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIV 93
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
30-176 |
9.65e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 37.95 E-value: 9.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489957763 30 AIADMAKDLSVREGAVQSVMAAYLLTYGVSQLVYGPLSDRVGRRPVILVGMSIFMVATMIAITTHSLTVLIAASALQGVG 109
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489957763 110 TGVGGVMARTLPRDMYQGTQLRHANSLLNMGILVSPLLAPLIGGLLDTVWSWRACYAFLLVLCIIVT 176
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL 167
|
|
| |
