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Conserved domains on  [gi|489958184|ref|WP_003861491|]
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MULTISPECIES: NADH-quinone oxidoreductase subunit NuoI [Gammaproteobacteria]

Protein Classification

NuoI/complex I 23 kDa subunit family protein( domain architecture ID 11481829)

NuoI/complex I 23 kDa subunit family protein such as bacterial NADH-quinone oxidoreductase subunit I (NuoI), which is part of the connecting domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

EC:  7.1.1.-
Gene Ontology:  GO:0016651|GO:0051539|GO:0016020
PubMed:  23417064|33957129|24059520

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
1-151 1.53e-77

NADH-quinone oxidoreductase subunit NuoI;


:

Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 228.61  E-value: 1.53e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   1 MTLKELLVGFGTQVRsiwmiglHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGSERCVACNLCAVACPVGCISLQKA 80
Cdd:PRK05888   8 MLLKELLKGLGVTLK-------YFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  81 ETVDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKEDLLISG--------PGKYPEYNFY 151
Cdd:PRK05888  81 EREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGdrvereiaPGKAADANYR 159
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
1-151 1.53e-77

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 228.61  E-value: 1.53e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   1 MTLKELLVGFGTQVRsiwmiglHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGSERCVACNLCAVACPVGCISLQKA 80
Cdd:PRK05888   8 MLLKELLKGLGVTLK-------YFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  81 ETVDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKEDLLISG--------PGKYPEYNFY 151
Cdd:PRK05888  81 EREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGdrvereiaPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 16-137 1.46e-67

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 201.88  E-value: 1.46e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   16 SIWMIGLHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGSERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFRIN 95
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 489958184   96 FSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKEDL 137
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 58-129 1.35e-20

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 80.56  E-value: 1.35e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETvdgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPdFELGEYKRQD 129
Cdd:COG1143    2 DKCIGCGLCVRVCPVDAITIEDGEP------GKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 57-136 1.13e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.04  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  57 SERCVACNLCAVACPVGCISLQKAETVdgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKED 136
Cdd:cd10549    5 PEKCIGCGICVKACPTDAIELGPNGAI-----ARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEEK 79
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 60-113 5.29e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.23  E-value: 5.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489958184   60 CVACNLCAVACPVGCISLQKAETVDGRwypEFFRINFSRCIFCGLCEEACPTTA 113
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGT---KTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 57-115 3.04e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 45.62  E-value: 3.04e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  57 SERCVACNLCAVACPVGCISLqkaetVDGRwyPEFfrinFSRCIFCGLCEEACPTTAIQ 115
Cdd:NF038196 184 TDKCIGCGICAKVCPVNNIEM-----EDGK--PVW----GHNCTHCLACIHRCPKEAIE 231
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
1-151 1.53e-77

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 228.61  E-value: 1.53e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   1 MTLKELLVGFGTQVRsiwmiglHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGSERCVACNLCAVACPVGCISLQKA 80
Cdd:PRK05888   8 MLLKELLKGLGVTLK-------YFFKKKVTIQYPEEKLPLSPRFRGRHALRRDPNGEERCIACKLCAAICPADAITIEAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  81 ETVDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKEDLLISG--------PGKYPEYNFY 151
Cdd:PRK05888  81 EREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLLANGdrvereiaPGKAADANYR 159
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 16-137 1.46e-67

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 201.88  E-value: 1.46e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   16 SIWMIGLHAFAKRETRMYPEEPVYLPPRYRGRIVLTRDPDGSERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFRIN 95
Cdd:TIGR01971   1 GLGLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 489958184   96 FSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKEDL 137
Cdd:TIGR01971  81 FGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 30-135 9.50e-24

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 92.02  E-value: 9.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  30 TRMYPEEPVYLPPRYRGRivltrdPD-GSERCVACNLCAVACPVGCISLQKAETVDGR-WypeffRINFSRCIFCGLCEE 107
Cdd:PRK12387  15 TSSYPLEPIAVDKNFRGK------PEyNPQQCIGCAACVNACPSNALTVETDLATGELaW-----EFNLGRCIFCGRCEE 83

                         90       100
                 ....*....|....*....|....*...
gi 489958184 108 ACPTTAIQLTPDFELGEYKRQDLVYEKE 135
Cdd:PRK12387  84 VCPTAAIKLSQEFELAVWKKEDLLQQSE 111
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 58-129 1.35e-20

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 80.56  E-value: 1.35e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETvdgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPdFELGEYKRQD 129
Cdd:COG1143    2 DKCIGCGLCVRVCPVDAITIEDGEP------GKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 30-130 2.21e-18

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 77.87  E-value: 2.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  30 TRMYPEEPVYLPPRYRGRIVLtrDPdgsERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFrinfSRCIFCGLCEEAC 109
Cdd:PRK08222  15 TVKYPFAPLEVSPGFRGKPDL--MP---SQCIACGACTCACPANALTIQTDDQQNSRTWQLYL----GRCIYCGRCEEVC 85

                         90       100
                 ....*....|....*....|.
gi 489958184 110 PTTAIQLTPDFELGEYKRQDL 130
Cdd:PRK08222  86 PTRAIQLTNNFELTVTNKADL 106
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 25-129 3.62e-16

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 70.63  E-value: 3.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  25 FAKRETRMYPE-EPVYLPPRYRGRIVLTRDpdgseRCVACNLCAVACPVGCISlqkaetvdgrWYPEFFRINF--SRCIF 101
Cdd:PRK08348  13 FKKPATNLFPAtEPVPVPEDFRGKILYDVD-----KCVGCRMCVTVCPAGVFV----------YLPEIRKVALwtGRCVF 77

                         90       100
                 ....*....|....*....|....*...
gi 489958184 102 CGLCEEACPTTAIQLTPDFELGEYKRQD 129
Cdd:PRK08348  78 CGQCVDVCPTGALQMSDDFLLASYDRFD 105
ndhI TIGR00403
NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]
 30-134 2.17e-15

NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]


Pssm-ID: 129498 [Multi-domain]  Cd Length: 183  Bit Score: 70.33  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   30 TRMYPEEPVYLPPRYRGRIVLTRDpdgseRCVACNLCAVACPVgcislqKAETVDGRWYPEF-------FRINFSRCIFC 102
Cdd:TIGR00403  39 TIQYPYEKLIPSERFRGRIHFEFD-----KCIACEVCVRVCPI------NLPVVDWEFNKAIkkkqlknYSIDFGVCIFC 107

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489958184  103 GLCEEACPTTAIQLTPDFELGEYKRQDLVYEK 134
Cdd:TIGR00403 108 GNCVEYCPTNCLSMTEEYELSTYDRHELNYDQ 139
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 57-136 1.13e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.04  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  57 SERCVACNLCAVACPVGCISLQKAETVdgrwyPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYEKED 136
Cdd:cd10549    5 PEKCIGCGICVKACPTDAIELGPNGAI-----ARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEEK 79
ndhI CHL00014
NADH dehydrogenase subunit I
 30-132 1.27e-14

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 67.86  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  30 TRMYPEEPVYLPPRYRGRIVLTRDpdgseRCVACNLCAVACPvgcISLQ----KAETVDGRWYPEFFRINFSRCIFCGLC 105
Cdd:CHL00014  36 TIQYPYEKLITSERFRGRIHFEFD-----KCIACEVCVRVCP---IDLPvvdwKLETDIRKKRLLNYSIDFGVCIFCGNC 107

                         90       100
                 ....*....|....*....|....*..
gi 489958184 106 EEACPTTAIQLTPDFELGEYKRQDLVY 132
Cdd:CHL00014 108 VEYCPTNCLSMTEEYELSTYDRHELNY 134
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
58-121 2.68e-13

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 61.67  E-value: 2.68e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958184  58 ERCVACNLCAVACPVGCISLQKaetvdgrwypEFFRINFSRCIFCGLCEEACPTTAIQLTPDFE 121
Cdd:COG2768   11 EKCIGCGACVKVCPVGAISIED----------GKAVIDPEKCIGCGACIEVCPVGAIKIEWEED 64
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 58-121 6.11e-13

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 62.41  E-value: 6.11e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFrINFSRCIFCGLCEEACPTTAIQLTPDFE 121
Cdd:cd10549   40 DKCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAE-IDEEKCIGCGLCVKVCPVDAITLEDELE 102
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 58-121 4.07e-12

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 58.91  E-value: 4.07e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958184  58 ERCVACNLCAVACPVGCISLqkaetVDGRWYpeffRINFSRCIFCGLCEEACPTTAIQLTPDFE 121
Cdd:COG1144   30 DKCIGCGLCWIVCPDGAIRV-----DDGKYY----GIDYDYCKGCGICAEVCPVKAIEMVPEEK 84
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 58-114 5.42e-12

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 58.14  E-value: 5.42e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  58 ERCVACNLCAVACPVGCISLqkaetVDGRwypefFRINFSRCIFCGLCEEACPTTAI 114
Cdd:COG2221   15 EKCIGCGLCVAVCPTGAISL-----DDGK-----LVIDEEKCIGCGACIRVCPTGAI 61
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 58-117 1.05e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 58.95  E-value: 1.05e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETVdgrwypeffRINFSRCIFCGLCEEACPTTAIQLT 117
Cdd:cd10549   78 EKCIGCGLCVKVCPVDAITLEDELEI---------VIDKEKCIGCGICAEVCPVNAIKLV 128
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 58-119 1.46e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 57.03  E-value: 1.46e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETVdgrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:COG1146    8 DKCIGCGACVEVCPVDVLELDEEGKK-------ALVINPEECIGCGACELVCPVGAITVEDD 62
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 60-113 5.29e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 55.23  E-value: 5.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489958184   60 CVACNLCAVACPVGCISLQKAETVDGRwypEFFRINFSRCIFCGLCEEACPTTA 113
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGT---KTVVIDPERCVGCGACVAVCPTGA 51
NapF COG1145
Ferredoxin [Energy production and conversion];
58-118 4.29e-10

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 57.04  E-value: 4.29e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  58 ERCVACNLCAVACPVGCISLqkaetVDGRWYPEFFRinfSRCIFCGLCEEACPTTAIQLTP 118
Cdd:COG1145  182 EKCIGCGLCVKVCPTGAIRL-----KDGKPQIVVDP---DKCIGCGACVKVCPVGAISLEP 234
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 58-118 4.97e-10

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 53.19  E-value: 4.97e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  58 ERCVACNLCAVACPVGCISLqkaetVDGRWYpeffRINFSRCIFCGLCEEACPTTAIQLTP 118
Cdd:COG1149   11 EKCIGCGLCVEVCPEGAIKL-----DDGGAP----VVDPDLCTGCGACVGVCPTGAITLEE 62
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 58-116 9.72e-10

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 52.74  E-value: 9.72e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  58 ERCVACNLCAVACPVGCISLQKaetvdgrwypEFFRINFSRCIFCGLCEEACPTTAIQL 116
Cdd:COG4231   22 DKCTGCGACVKVCPADAIEEGD----------GKAVIDPDLCIGCGSCVQVCPVDAIKL 70
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
45-121 1.45e-09

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 55.45  E-value: 1.45e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  45 RGRIVLTRDPDgseRCVACNLCAVACPVGCISLQKaetvdgrwypeffRINFSRCIFCGLCEEACPTTAIQLTPDFE 121
Cdd:COG0348  200 LSTLRVRYDRG---DCIDCGLCVKVCPMGIDIRKG-------------EINQSECINCGRCIDACPKDAIRFSSRGE 260
PRK13984 PRK13984
putative oxidoreductase; Provisional
 25-120 1.69e-08

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 52.85  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  25 FAKRETRMYPEEPVYLPPRYRGRIVltrdpDGSERCVACNLCAVACPVGCISLQKAETVDGRW--YPEFFRINFSRCIFC 102
Cdd:PRK13984  17 FRKPVTIKVPNVKREAAERYRGFHI-----NDWEKCIGCGTCSKICPTDAITMVEVPDLPQEYgkKPQRPVIDYGRCSFC 91

                         90
                 ....*....|....*...
gi 489958184 103 GLCEEACPTTAIQLTPDF 120
Cdd:PRK13984  92 ALCVDICTTGSLKMTREY 109
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 58-117 2.58e-08

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 50.32  E-value: 2.58e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489958184  58 ERCVACNLCAVACPVGCISLQkaetVDGrwYPEffrINFSR--CIFCGLCEEACPTTAIQLT 117
Cdd:cd10564   13 DLCTRCGDCVEACPEGIIVRG----DGG--FPE---LDFSRgeCTFCGACAEACPEGALDPA 65
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
58-116 9.25e-08

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 50.63  E-value: 9.25e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  58 ERCVACNLCAVACPVGCISlqkaetVDGRWYPEffrINFSRCIFCGLCEEACPTTAIQL 116
Cdd:COG1148  496 EKCTGCGRCVEVCPYGAIS------IDEKGVAE---VNPALCKGCGTCAAACPSGAISL 545
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 57-116 1.20e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 48.80  E-value: 1.20e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958184  57 SERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFRINFsRCIFCG------LCEEACPTTAIQL 116
Cdd:cd10554   84 EERCIGCKLCVLACPFGAIEMAPTTVPGVDWERGPRAVAV-KCDLCAgreggpACVEACPTKALTL 148
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 41-119 2.05e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 47.77  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  41 PPRYRGRIVLTRDPDGSERCVACNLC-----AVACPVGCISLQKAETVdgrwypeffRINFSRCIFCGLCEEACPTTAIQ 115
Cdd:cd04410   28 PDWSRIKVIEGGGLERAFLPVSCMHCedppcVKACPTGAIYKDEDGIV---------LIDEDKCIGCGSCVEACPYGAIV 98


                 ....
gi 489958184 116 LTPD 119
Cdd:cd04410   99 FDPE 102
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
58-121 2.16e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 49.64  E-value: 2.16e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETvdgrwypeffRINFSRCIFCGLCEEACPTTAIQLTPDFE 121
Cdd:COG4624   91 EKCKNCYPCVRACPVKAIKVDDGKA----------EIDEEKCISCGQCVAVCPFGAITEKSDIE 144
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
50-117 2.27e-07

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 47.73  E-value: 2.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958184  50 LTRDPDG----SERCVACNLCAVACPVGCIslqkaetvdgRWYPEFFRINFSRCIFCG------LCEEACPTTAIQLT 117
Cdd:COG1142   69 ITRDDGAvvvdEEKCIGCGLCVLACPFGAI----------TMVGEKSRAVAVKCDLCGgreggpACVEACPTGALRLV 136
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 59-121 2.42e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 48.02  E-value: 2.42e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  59 RCVACNLCAVACPVGCISLQKAET-VDGRWYPeffRINFSR--CIFCG-LCEEACPTTAIQLTPDFE 121
Cdd:cd16373   15 LCIRCGLCVEACPTGVIQPAGLEDgLEGGRTP---YLDPREgpCDLCCdACVEVCPTGALRPLDLEE 78
Fer4_9 pfam13187
4Fe-4S dicluster domain;
59-114 2.44e-07

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 45.62  E-value: 2.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489958184   59 RCVACNLCAVACPVGCISLQKAETVDgrwypeFFRINFSRCIFCGLCEEACPTTAI 114
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTI------RGDIAGLACIGCGACVDACPRGAI 50
PRK13795 PRK13795
hypothetical protein; Provisional
 57-110 3.64e-07

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 49.22  E-value: 3.64e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489958184  57 SERCVACNLCAVACPVGCISLqKAETVDgrwypefFRINFSRCIFCGLCEEACP 110
Cdd:PRK13795 580 AAECVGCGVCVGACPTGAIRI-EEGKRK-------ISVDEEKCIHCGKCTEVCP 625
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 60-118 1.96e-06

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 46.53  E-value: 1.96e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  60 CVACNLCAVACPVGCISlqkaetVDGRWYPeffRINFSRCIFCGLCEEACPTTAIQLTP 118
Cdd:COG2878  139 CIGCGDCIKACPFDAIV------GAAKGMH---TVDEDKCTGCGLCVEACPVDCIEMVP 188
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 58-110 2.52e-06

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 43.01  E-value: 2.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489958184   58 ERCVACNLCAVACPVGCISLQKAEtvdGRWYPEFFRINFSRCIFCGLCEEACP 110
Cdd:pfam13237   7 DKCIGCGRCTAACPAGLTRVGAIV---ERLEGEAVRIGVWKCIGCGACVEACP 56
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 57-115 3.04e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 45.62  E-value: 3.04e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  57 SERCVACNLCAVACPVGCISLqkaetVDGRwyPEFfrinFSRCIFCGLCEEACPTTAIQ 115
Cdd:NF038196 184 TDKCIGCGICAKVCPVNNIEM-----EDGK--PVW----GHNCTHCLACIHRCPKEAIE 231
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
35-118 3.05e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 44.65  E-value: 3.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  35 EEPVYLPPRYRGRIVLTRDPDGSERCVACNL--CAVACPVGCISLQkaetvDGRWYpeffrINFSRCIFCGLCEEACPTT 112
Cdd:COG1142   27 EGEEGEPFLPRIRVVRKAGVSAPVQCRHCEDapCAEVCPVGAITRD-----DGAVV-----VDEEKCIGCGLCVLACPFG 96


                 ....*.
gi 489958184 113 AIQLTP 118
Cdd:COG1142   97 AITMVG 102
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 57-122 3.10e-06

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 43.78  E-value: 3.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958184   57 SERCVACNLCAVACPVGCISLQKAEtvdgrwYPEFfRINFSRCIFCGLCEEACPTTAiqLTPDFEL 122
Cdd:TIGR00402  33 SAVCTRCGECASACENNILQLGQQG------QPTV-EFDNAECDFCGKCAEACPTNA--FHPRFPG 89
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
60-117 3.51e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 45.69  E-value: 3.51e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489958184  60 CVACNLCAVACPVGCISLqkaetVDGRWYpeffrINFSRCIFCGLCEEACPTTAIQLT 117
Cdd:PRK07118 215 CIGCGKCVKACPAGAITM-----ENNLAV-----IDQEKCTSCGKCVEKCPTKAIRIL 262
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-119 6.41e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 43.71  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  57 SERCVACNLCAVAC------PVGcISLQKAETVDGRWYPEFFRINFS--------------------------------- 97
Cdd:cd16371    6 QERCIGCKACEIACkdkndlPPG-VNWRRVYEYEGGEFPEVFAYFLSmscnhcenpacvkvcptgaitkredgivvvdqd 84

                         90       100
                 ....*....|....*....|..
gi 489958184  98 RCIFCGLCEEACPTTAIQLTPD 119
Cdd:cd16371   85 KCIGCGYCVWACPYGAPQYNPE 106
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 60-118 7.09e-06

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 45.25  E-value: 7.09e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  60 CVACNLCAVACPVGCISLQKAetvdGRWYpeffRINFSRCIFCGLCEEACPTTAIQLTP 118
Cdd:PRK12771 512 CFECDNCYGACPQDAIIKLGP----GRRY----HFDYDKCTGCHICADVCPCGAIEMGP 562
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 58-118 7.75e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 43.78  E-value: 7.75e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  58 ERCVA------CNLCAVACPVGCISLQKaetVDGRWYPEffrINFSRCIFCGLCEEACPTT---AIQLTP 118
Cdd:cd16373   91 DRCLAwqggtdCGVCVEACPTEAIAIVL---EDDVLRPV---VDEDKCVGCGLCEYVCPVEppkAIVVEP 154
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 58-116 8.01e-06

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 42.71  E-value: 8.01e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  58 ERCVACNLCAVACPVGCISLqkaetvDGRWYPEFfriNFSRCIFCGLCEEACPTTAIQL 116
Cdd:PRK09624  51 DKCVRCYLCYIYCPEPAIYL------DEEGYPVF---DYDYCKGCGICANECPTKAIEM 100
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 50-145 1.07e-05

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 43.74  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  50 LTRDPDG-----SERCVACNLCAVACPVGCISLQkaetvdgrWYPEFFRInfSRCIFC------GL---CEEACPTTAIQ 115
Cdd:cd10561   86 LRKTPEGpvtydEDKCIGCRYCMVACPFNIPKYE--------WDSANPKI--RKCTMCydrlkeGKqpaCVEACPTGALL 155

                         90       100       110
                 ....*....|....*....|....*....|
gi 489958184 116 ltpdFelGeyKRQDLVYEKEDLLISGPGKY 145
Cdd:cd10561  156 ----F--G--KREELLAEAKRRIAANPGRY 177
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 59-114 1.11e-05

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 42.40  E-value: 1.11e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  59 RCVACNLCAVACPVGCISL-QKAETVDGRW----YPEffrinfsRCIFCGLCEEACPTTAI 114
Cdd:PRK09626  17 RCKACDICVSVCPAGVLAMrIDPHAVLGKMikvvHPE-------SCIGCRECELHCPDFAI 70
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 61-118 1.27e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 43.00  E-value: 1.27e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489958184  61 VACNLCAVACPVGCISLQkaETVDGRWYPEffrINFSRCIFCGLCEEACPTTAIQLTP 118
Cdd:cd10564   86 VECRSCQDACPTQAIRFR--PRLGGIALPE---LDADACTGCGACVSVCPVGAITLTP 138
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 59-116 1.28e-05

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 44.22  E-value: 1.28e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  59 RCVACNLCAVACPVGCI--SLQKAETVDGRWY-PEFFRINFSRCIFCGLCEEACPTTAIQL 116
Cdd:PRK14028 248 KCIMCRKCWLYCPDDAIieAWREAEGPRGRKFrMKMIDFDYQYCKGCGVCAEVCPTGAIQM 308
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 49-116 1.42e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 42.71  E-value: 1.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489958184  49 VLTRDPDGSER-----CVACNLCAVACPVGciSLQKAETvdgrwypeffRINFSRCIFCGLCEEACPTTAIQL 116
Cdd:cd16372   63 AITRDANGVVMinkklCVGCLMCVGFCPEG--AMFKHED----------YPEPFKCIACGICVKACPTGALEL 123
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 50-116 1.48e-05

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 42.76  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  50 LTRDPDG-----SERCVACNLCAVACPVGCISLQKAETVDgrwypeffrinfSRCIFCG---------LCEEACPTTAIQ 115
Cdd:cd04410   67 IYKDEDGivlidEDKCIGCGSCVEACPYGAIVFDPEPGKA------------VKCDLCGdrldeglepACVKACPTGALT 134


                 .
gi 489958184 116 L 116
Cdd:cd04410  135 F 135
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 66-143 1.51e-05

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 43.02  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  66 CAVACPVGCISLQkaetvDGRwypefFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQDLVYE--KEDLLISGPG 143
Cdd:cd10554   64 CANVCPVGAISQE-----DGV-----VQVDEERCIGCKLCVLACPFGAIEMAPTTVPGVDWERGPRAVavKCDLCAGREG 133
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 50-127 1.83e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 42.65  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  50 LTRDPDGS-----ERCVACNLCAVACPVGCISLQKAETVdgrwypeffrinFSRCIFCG---------LCEEACPTTAIQ 115
Cdd:cd16374   60 IYRDEDGAvlvdpDKCIGCGMCAMACPFGVPRFDPSLKV------------AVKCDLCIdrrregklpACVEACPTGALK 127

                         90
                 ....*....|..
gi 489958184 116 LTPDFELGEYKR 127
Cdd:cd16374  128 FGDIEELLKEKR 139
PRK09898 PRK09898
ferredoxin-like protein;
59-118 2.26e-05

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 43.29  E-value: 2.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  59 RCVACNLCAVACPVGcislqkAETVDgrwyPEFFRInfSRCIFCGLCEEACPTTAIQLTP 118
Cdd:PRK09898 155 RCIGCSACTTACPWM------MATVN----TESKKS--SKCVLCGECANACPTGALKIIE 202
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 57-115 2.47e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 43.06  E-value: 2.47e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  57 SERCVACNLCAVACPVGCISLQ--KAETVDGRWYPEFFRINFSRCIfcGLCEEACPTTAIQ 115
Cdd:COG2878  166 EDKCTGCGLCVEACPVDCIEMVpvSPTVVVSSWDKGKAVRKVVGCI--GLCCKKCCPAAAI 224
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 44-119 2.88e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 41.79  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  44 YRGRI-VLTRDPDGSERCVACN-----LCAVACPVGCISLQKAetvDGRWypeffRINFSRCIFCGLCEEACPTTAIQLT 117
Cdd:cd10550   29 SLSRIrVVRFEPEGLDVPVVCRqcedaPCVEACPVGAISRDEE---TGAV-----VVDEDKCIGCGMCVEACPFGAIRVD 100


                 ..
gi 489958184 118 PD 119
Cdd:cd10550  101 PE 102
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 52-114 4.63e-05

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 42.13  E-value: 4.63e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  52 RDPDG-----SERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFRINFSRCIFC------GL---CEEACPTTAI 114
Cdd:cd10551   72 KREDGivlvdYDKCIGCRYCMAACPYGARYFNPEEPHEFGEVPVRPKGVVEKCTFCyhrldeGLlpaCVEACPTGAR 148
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 58-128 5.24e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 42.81  E-value: 5.24e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETVDGRwypefFRINFSRCIFCG------LCEEACPTTAIQLTPDFELGEYKRQ 128
Cdd:PRK12769  85 QKCIGCKSCVVACPFGTMQIVLTPVAAGK-----VKATAHKCDLCAgrengpACVENCPADALQLVTEQALSGMAKS 156
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 63-123 5.46e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 41.47  E-value: 5.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  63 CNLCAVACPVGCI---SLQKAETVDGRwypefFRINFSRCI------FCGLCEEACPTTAIQLTPDFELG 123
Cdd:cd16373   59 CDACVEVCPTGALrplDLEEQKVKMGV-----AVIDKDRCLawqggtDCGVCVEACPTEAIAIVLEDDVL 123
PRK06273 PRK06273
ferredoxin; Provisional
 57-110 9.63e-05

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 40.85  E-value: 9.63e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  57 SERCVACNLCAVACPVGCISLQKAETV---DGRWYPEFFRINFSRCIFCGLCEEACP 110
Cdd:PRK06273  48 EELCIGCGGCANVCPTKAIEMIPVEPVkitEGYVKTKIPKIDYEKCVYCLYCHDFCP 104
PRK09898 PRK09898
ferredoxin-like protein;
66-110 1.09e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 40.97  E-value: 1.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 489958184  66 CAVACPVGCISLQKAEtvdGRWYpeffrINFSRCIFCGLCEEACP 110
Cdd:PRK09898 131 CMNVCPIGAITWQQKE---GCIT-----VDHKRCIGCSACTTACP 167
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 57-111 1.24e-04

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 40.12  E-value: 1.24e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489958184  57 SERCVACNLCAVACPVGCIsLQKAETVDGrwypeffrINFSRCIFCGLCEEACPT 111
Cdd:PRK09625  58 NEICINCFNCWVYCPDAAI-LSRDKKLKG--------VDYSHCKGCGVCVEVCPT 103
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
58-82 1.26e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 41.47  E-value: 1.26e-04
                         10        20
                 ....*....|....*....|....*.
gi 489958184  58 ERCVACNLCAVACPV-GCISLQKAET 82
Cdd:PRK08318 377 EECVGCNLCAHVCPVeGCITMGEVKF 402
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 94-115 1.48e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 37.61  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|..
gi 489958184   94 INFSRCIFCGLCEEACPTTAIQ 115
Cdd:pfam00037   3 IDEEKCIGCGACVEVCPVGAIT 24
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 83-116 1.94e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 38.11  E-value: 1.94e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 489958184  83 VDGRWYPeffRINFSRCIFCGLCEEACPTTAIQL 116
Cdd:COG2221    4 IIGTWPP---KIDEEKCIGCGLCVAVCPTGAISL 34
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 58-119 2.13e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.93  E-value: 2.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  58 ERCVACNLCAVAC------PVGcISLQKAETVDGRWYPEFFRINFSR-CIFCG--LCEEACPTTAIQLTPD 119
Cdd:COG0437   13 TKCIGCRACVVACkeennlPVG-VTWRRVRRYEEGEFPNVEWLFVPVlCNHCDdpPCVKVCPTGATYKRED 82
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 50-115 2.26e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.93  E-value: 2.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  50 LTRDPDG-----SERCVACNLCAVACPVGCISLQKAETVdgrwypeffrinFSRCIFCG---------LCEEACPTTAIQ 115
Cdd:COG0437   77 TYKREDGivlvdYDKCIGCRYCVAACPYGAPRFNPETGV------------VEKCTFCAdrldegllpACVEACPTGALV 144
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 66-119 2.66e-04

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 39.59  E-value: 2.66e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489958184  66 CAVACPVGCISLQKAETVDgrwypeffrINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:cd10562   78 CVKVCPTGALYKTENGAVV---------VDEDKCIGCGYCVAACPFDVPRYDET 122
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
58-116 2.98e-04

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 38.39  E-value: 2.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489958184  58 ERCVACNLCAVACPVGCISLQKaetvDGrwypeFFRINFSRCIFCGLCEEACPTTAIQL 116
Cdd:PRK09623  51 SKCVKCYICWKFCPEPAIYIKE----DG-----YVAIDYDYCKGCGICANECPTKAITM 100
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 60-119 3.02e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 38.86  E-value: 3.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  60 CVACNLCAVACPVGCISLQKAETVdgrwypeffRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:cd16372   49 CNQCGECIDVCPTGAITRDANGVV---------MINKKLCVGCLMCVGFCPEGAMFKHED 99
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 60-134 3.38e-04

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 39.68  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  60 CVACNLCAVACPVGCISLQKAetvDGRWYpeffrinfsRCIFC------GL---CEEACPTTAIQLTPDFELGE--YKRQ 128
Cdd:cd10560  110 CNGCGYCVAACPFGVIDRNEE---TGRAH---------KCTLCydrlkdGLepaCAKACPTGSIQFGPLEELREraRARV 177


                 ....*.
gi 489958184 129 DLVYEK 134
Cdd:cd10560  178 EQLHEQ 183
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
58-118 4.71e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 39.93  E-value: 4.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489958184  58 ERCVACNLCAVACPVG---CISLqkaeTVDGRWYPEffrINFSRCIFCGLCEEACPT-TAIQLTP 118
Cdd:PRK08318 342 DKCIGCGRCYIACEDTshqAIEW----DEDGTRTPE---VIEEECVGCNLCAHVCPVeGCITMGE 399
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 80-119 5.18e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 37.34  E-value: 5.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489958184  80 AETVDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:COG1144   13 AAYKTGGWRVERPVVDEDKCIGCGLCWIVCPDGAIRVDDG 52
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 94-119 5.31e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 38.15  E-value: 5.31e-04
                         10        20
                 ....*....|....*....|....*.
gi 489958184  94 INFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:cd10549    3 YDPEKCIGCGICVKACPTDAIELGPN 28
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 57-131 5.87e-04

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 39.10  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  57 SERCVACNLCAVACPVGCISLQKAETVDGRWYPeffrinfsrCIFCGLCEEACPTTAIQLTPD-----FEL---GEYKRQ 128
Cdd:PRK00783 168 SEDCDECEKCVEACPRGVLELKEGKLVVTDLLN---------CSLCKLCERACPGKAIRVSDDenkfiFTVesdGSLPVE 238


                 ...
gi 489958184 129 DLV 131
Cdd:PRK00783 239 EIL 241
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 58-119 8.39e-04

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 38.28  E-value: 8.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958184  58 ERCVACNLCAVAC------PVGcISLQKAETVDGRWYPEFFRINFSR-CIFCG--LCEEACPTTAIQLTPD 119
Cdd:cd10551    6 RKCIGCGACVVACkaennvPPG-VFRNRVLEYEVGEYPNVKRTFLPVlCNHCEnpPCVKVCPTGATYKRED 75
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 93-119 9.01e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 36.24  E-value: 9.01e-04
                         10        20
                 ....*....|....*....|....*..
gi 489958184  93 RINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:COG1149    7 VIDEEKCIGCGLCVEVCPEGAIKLDDG 33
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 52-111 9.25e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 37.38  E-value: 9.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184   52 RDPDGSERCVACNLCAVACPVGcISLQKAETVDgrwypeffrinfsrCIFCGLCEEACPT 111
Cdd:pfam13746  53 RQQKGVGDCIDCESCVQVCPTG-IDIRKGLQLE--------------CINCGLCIDACNT 97
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 44-116 1.04e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 37.67  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  44 YRGRIVLTRDPDgseRCVACNLCAVAC----------------------PVGCISLQKAETVDG------RWYPE-FFRI 94
Cdd:cd16367    8 IQGTNLLVIDLD---RCIRCDNCEKACadthdghsrldrnglrfgnllvPTACRHCVDPVCMIGcptgaiHRDDGgEVVI 84

                         90       100
                 ....*....|....*....|..
gi 489958184  95 NfSRCIFCGLCEEACPTTAIQL 116
Cdd:cd16367   85 S-DACCGCGNCASACPYGAIQM 105
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 50-116 1.05e-03

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 37.62  E-value: 1.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958184  50 LTRDP-DG-----SERCVACNLCAVACPVGCISLQKAETVdgrwypeffrinFSRCIFCG-----LCEEACPTTAIQL 116
Cdd:cd10563   74 MHKDPeTGivihdEEKCVGCWMCVMVCPYGAIRPDKERKV------------ALKCDLCPdretpACVEACPTGALVL 139
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 57-119 1.21e-03

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 38.40  E-value: 1.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489958184  57 SERCVACNLCAVACPVGCISLQKAETVDGRWYPeffrinfsrCIFCGLCEEACPTTAIQLTPD 119
Cdd:cd07030  168 DEDCDGCGKCVEECPRGVLELEEGKVVVEDLED---------CSLCKLCERACDAGAIRVGWD 221
NapF COG1145
Ferredoxin [Energy production and conversion];
60-119 1.30e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 38.17  E-value: 1.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  60 CVACNLCAVACPVGCISLQKAETVDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:COG1145  145 AILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDG 204
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 58-128 1.53e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 38.47  E-value: 1.53e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958184  58 ERCVACNLCAVACPVGCIslqkaETVDGRwypeffrinFSRCIFCG-------LCEEACPTTAIQLTPDFELGEYKRQ 128
Cdd:PRK12809  85 QKCIGCKRCAIACPFGVV-----EMVDTI---------AQKCDLCNqrssgtqACIEVCPTQALRLMDDKGLQQIKVA 148
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 91-129 1.56e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.46  E-value: 1.56e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 489958184  91 FFRINFSRCIFCGLCEEACPTTAIQLTPDFELGEYKRQD 129
Cdd:COG1146    2 MPVIDTDKCIGCGACVEVCPVDVLELDEEGKKALVINPE 40
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 58-111 1.61e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 35.33  E-value: 1.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489958184   58 ERCVACNLCAVACPVGCIslqKAETVDGRWYpefFRINFSRCIFCGLCEEACPT 111
Cdd:pfam14697   6 DTCIGCGKCYIACPDTSH---QAIVGDGKRH---HTVIEDECTGCNLCVSVCPV 53
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-116 1.72e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.87  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489958184  40 LPPRYRGRIVLTRDpdgseRCVACNLCAVACPVGCIslqkaetvdgRWYPEFFRINFsrCIFCGLCEEACPTTAIQL 116
Cdd:cd16370   70 LEPRKGGGVVLDKE-----KCIGCGNCVKACIVGAI----------FWDEETNKPII--CIHCGYCARYCPHDVLAM 129
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
60-119 2.35e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 37.61  E-value: 2.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  60 CVACNLCAVACPVGCISLqkaetVDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:PRK07118 141 CLGLGSCVAACPFDAIHI-----ENG-----LPVVDEDKCTGCGACVKACPRNVIELIPK 190
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 60-120 2.52e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.48  E-value: 2.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489958184  60 CVACNL--CAVACPVGCISLQKAETVdgrwypeffRINFSRCIFCGLCEEACPTTAIQLTPDF 120
Cdd:cd16370   53 CRACEDppCAEACPTGALEPRKGGGV---------VLDKEKCIGCGNCVKACIVGAIFWDEET 106
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 48-110 2.75e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 37.43  E-value: 2.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958184  48 IVLTRD--PDGSER-CVACNLCAVACPVGCISLQKAETVDGRWYPEFFRINFSRCIFCGLCEEACP 110
Cdd:COG4656  351 LALTKEevPPPEEQpCIRCGRCVDACPMGLLPQQLYWYARAGDFDKAEEYNLMDCIECGCCSYVCP 416
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-116 3.16e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 36.13  E-value: 3.16e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958184  52 RDPDG----SERCVACNLCAVACPVGCISLQKAetvdgrwypeffrinfSRCIFCG-----LCEEACPTTAIQL 116
Cdd:cd16367   76 RDDGGevviSDACCGCGNCASACPYGAIQMVRA----------------VKCDLCAgyagpACVSACPTGAAIR 133
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 50-115 3.70e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 36.22  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  50 LTRDPDG-----SERCVACNLCAVACPVGCISLQKaetVDGRWYpeffrinfsRCIFC------GL---CEEACPTTAIQ 115
Cdd:cd16366   87 IIRTETGtvvvdPETCIGCGYCVNACPFDIPRFDE---ETGRVA---------KCTLCydrisnGLqpaCVKTCPTGALT 154
PRK06991 PRK06991
electron transport complex subunit RsxB;
58-118 3.77e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 36.70  E-value: 3.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489958184  58 ERCVACNLCAVACPVGCI--SLQKAETVDGRWypeffrinfsrCIFCGLCEEACPTTAIQLTP 118
Cdd:PRK06991  85 QLCIGCTLCMQACPVDAIvgAPKQMHTVLADL-----------CTGCDLCVPPCPVDCIDMVP 136
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 58-76 3.90e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 33.38  E-value: 3.90e-03
                          10
                  ....*....|....*....
gi 489958184   58 ERCVACNLCAVACPVGCIS 76
Cdd:pfam00037   6 EKCIGCGACVEVCPVGAIT 24
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 58-110 5.02e-03

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 36.59  E-value: 5.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958184  58 ERCVACNLCAVACPV------------GCISLQKA---ETVDGRWYPEFFRInFSRCIFCGLCEEACP 110
Cdd:COG0247   78 DACVGCGFCRAMCPSykatgdekdsprGRINLLREvleGELPLDLSEEVYEV-LDLCLTCKACETACP 144
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 59-111 5.16e-03

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 36.62  E-value: 5.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489958184  59 RCVACNLCAVACPVGC-ISLQKAETVDGRWYPefFRINFSRCIFCGLCEEACPT 111
Cdd:cd01916  366 KCTDCGWCTRACPNSLrIKEAMEAAKEGDFSG--LADLFDQCVGCGRCEQECPK 417
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 66-119 5.28e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 36.08  E-value: 5.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489958184  66 CAVACPVGCISlqKAEtvDGrwypeFFRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:COG0437   68 CVKVCPTGATY--KRE--DG-----IVLVDYDKCIGCRYCVAACPYGAPRFNPE 112
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
28-115 6.49e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.54  E-value: 6.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958184  28 RETRMYPEEPVYLPPRYRGRIVLTRDPDGSERCVACNLCAVACPVGCISLQKAETVDGRwyPEFFRINFSRCIFCGLCEE 107
Cdd:COG4624   24 EAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKR--GPSIIRDKEKCKNCYPCVR 101


                 ....*...
gi 489958184 108 ACPTTAIQ 115
Cdd:COG4624  102 ACPVKAIK 109
PRK10330 PRK10330
electron transport protein HydN;
58-114 8.27e-03

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 35.64  E-value: 8.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958184  58 ERCVACNLCAVACPVGCISLQKAETVDGRWYPEFFRINFSRCIFCGLCE---------EACPTTAI 114
Cdd:PRK10330  87 ERCIGCKTCVVACPYGAMEVVVRPVIRNSGAGLNVRAEKAEANKCDLCNhredgpacmAACPTHAL 152
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 49-85 8.77e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 33.53  E-value: 8.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 489958184  49 VLTRDPDGS-------ERCVACNLCAVACPVGCISLQKAETVDG 85
Cdd:COG1146   24 VLELDEEGKkalvinpEECIGCGACELVCPVGAITVEDDEPEEQ 67
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
89-119 8.79e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 35.99  E-value: 8.79e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 489958184  89 PEFFRINFSRCIFCGLCEEACPTTAIQLTPD 119
Cdd:COG1148  488 PSVAEVDPEKCTGCGRCVEVCPYGAISIDEK 518
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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