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Conserved domains on  [gi|489958946|ref|WP_003862253|]
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MULTISPECIES: OpgC domain-containing protein [Enterobacter]

Protein Classification

acyltransferase family protein( domain architecture ID 229463)

acyltransferase family protein similar to Curvularia lunata acyltransferase clz18, part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS)

EC:  2.3.1.-
Gene Ontology:  GO:0016747

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
OpgC super family cl44099
Predicted acyltransferase [General function prediction only];
16-396 6.75e-34

Predicted acyltransferase [General function prediction only];


The actual alignment was detected with superfamily member COG4645:

Pssm-ID: 443683  Cd Length: 372  Bit Score: 129.60  E-value: 6.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  16 PTTWRYIASDKRDLRIDFMRGIALVMMVVAHTeVMSIFNIFTWERFGLVTGAEGFVILSGFMLGMLNRVRLQKAVLLTIS 95
Cdd:COG4645    3 APAPAAPAPMGRDLRLDFFRGLALVFIFINHI-PGNVLERLTHRNFGFSDAAEGFVFLSGYAAALAYGRRFARGGFLAAT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  96 WGLYLRAWK--------IYRINIIIILSFLLLGYLPFINVFEVTHFTDRYSGTTWSLypVTPQIKETWFNI----VLYLQ 163
Cdd:COG4645   82 ARILRRAWQlyvahialFVLALALIALLALLFGNPDYLEELNLGPLLADPLGALLGL--LLLTYQPGYFDIlplyIVLLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946 164 IGPhqtqilglyifllllsplFLGMLQKGYVYWLLGLSLLVY--GGWQMWPVRATPSQFEFAFPLLAWQFIFVLGMCSGW 241
Cdd:COG4645  160 LAP------------------LLLWLARRRPWLVLALSVALWlaAQLFGLNLPAYPDGGGWFFNPFAWQLLFVLGLVLGL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946 242 Y-KEDLISFARTPAGKVVLVALVIIALLLGFIAQNHTNPFMPPAllmhslspedfnAFYHTWAAKNGLGPVRVLNDICLM 320
Cdd:COG4645  222 GrARGRRLVPRSRWLVWLALAYLLFSLVLVLFPFWWLVPALLWL------------PALLPLFDKTNLSPLRLLHFLALA 289

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958946 321 VTVYLVLTWCWLPLYRLAGWFLIPLGQHSLYTFILHVYVVFLVsQFVTFDLWRqDWIVNTFIHAAALGVLWLMAKY 396
Cdd:COG4645  290 YLVAWLLPAGWRALRSRLLRPLILLGRHSLPVFCAGVVLSLAG-QIVLDVTGG-GPLLQTAVNLAGIALLLAVAYL 363
 
Name Accession Description Interval E-value
OpgC COG4645
Predicted acyltransferase [General function prediction only];
16-396 6.75e-34

Predicted acyltransferase [General function prediction only];


Pssm-ID: 443683  Cd Length: 372  Bit Score: 129.60  E-value: 6.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  16 PTTWRYIASDKRDLRIDFMRGIALVMMVVAHTeVMSIFNIFTWERFGLVTGAEGFVILSGFMLGMLNRVRLQKAVLLTIS 95
Cdd:COG4645    3 APAPAAPAPMGRDLRLDFFRGLALVFIFINHI-PGNVLERLTHRNFGFSDAAEGFVFLSGYAAALAYGRRFARGGFLAAT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  96 WGLYLRAWK--------IYRINIIIILSFLLLGYLPFINVFEVTHFTDRYSGTTWSLypVTPQIKETWFNI----VLYLQ 163
Cdd:COG4645   82 ARILRRAWQlyvahialFVLALALIALLALLFGNPDYLEELNLGPLLADPLGALLGL--LLLTYQPGYFDIlplyIVLLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946 164 IGPhqtqilglyifllllsplFLGMLQKGYVYWLLGLSLLVY--GGWQMWPVRATPSQFEFAFPLLAWQFIFVLGMCSGW 241
Cdd:COG4645  160 LAP------------------LLLWLARRRPWLVLALSVALWlaAQLFGLNLPAYPDGGGWFFNPFAWQLLFVLGLVLGL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946 242 Y-KEDLISFARTPAGKVVLVALVIIALLLGFIAQNHTNPFMPPAllmhslspedfnAFYHTWAAKNGLGPVRVLNDICLM 320
Cdd:COG4645  222 GrARGRRLVPRSRWLVWLALAYLLFSLVLVLFPFWWLVPALLWL------------PALLPLFDKTNLSPLRLLHFLALA 289

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958946 321 VTVYLVLTWCWLPLYRLAGWFLIPLGQHSLYTFILHVYVVFLVsQFVTFDLWRqDWIVNTFIHAAALGVLWLMAKY 396
Cdd:COG4645  290 YLVAWLLPAGWRALRSRLLRPLILLGRHSLPVFCAGVVLSLAG-QIVLDVTGG-GPLLQTAVNLAGIALLLAVAYL 363
OpgC_C pfam10129
OpgC protein; This domain, found in various hypothetical and OpgC prokaryotic proteins. It is ...
 27-396 3.67e-32

OpgC protein; This domain, found in various hypothetical and OpgC prokaryotic proteins. It is likely to act as an acyltransferase enzyme.


Pssm-ID: 431075  Cd Length: 358  Bit Score: 124.64  E-value: 3.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946   27 RDLRIDFMRGIALVMMVVAHTeVMSIFNIFTWERFGLVTGAEGFVILSGFMLGM--LNRVRLQKAVLLTISwgLYLRAWK 104
Cdd:pfam10129   1 RDLRLDFFRGLALVFIFVDHI-PGNVLSWLTLRNFGFSDAAEVFVFLSGYAAGMayGRAMARRGWLAAAAR--ILRRAWQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  105 IYRINIIIILSFLLLGYLPFINVFEvthfTDRYSGTTWSLYPVTPQikETWFNIVLyLQIGPHQTQILGLYIFLLLLSPL 184
Cdd:pfam10129  78 LYVAHIALFVLVLALIALLALLFDN----PDYIDEFNLAPLLAQPL--ETLVGILL-LRYQPGYLDILPLYVVLLLLFPL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  185 FLGMLQKGyVYWLLGLSLLVYGGWQM--WPVRATPSQFEFAFPLLAWQFIFVLGMCSGWYKEDLISFARTPAGKVVL-VA 261
Cdd:pfam10129 151 ILWLALRG-PWLVLALSVLLWALAQLfgWNLPAYPSGGGWYFNPFAWQLLFVLGLWCGAGGRTGRRPLPGSRWLVWLaAA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  262 LVIIALLLGFIAQNHTNPFMPPALLMHSLSPEDfnafyhtwaaKNGLGPVRVLNDICLMVTVYLVLTWCWLPLYRLAGWF 341
Cdd:pfam10129 230 YLLFALVLTLAWLWPLLAALLPEALPQALYPID----------KTNLAPLRLLHFLALAYLVARLVPAGWRGLRRRWLRP 299

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489958946  342 LIPLGQHSLYTFILHVYVVFLVsQFVTFDLwRQDWIVNTFIHAAALGVLWLMAKY 396
Cdd:pfam10129 300 LILLGRHSLPVFCVGVVLSFLG-HSLLDTT-GGGLWMQLAVSAVGIALLAAVAYL 352
 
Name Accession Description Interval E-value
OpgC COG4645
Predicted acyltransferase [General function prediction only];
16-396 6.75e-34

Predicted acyltransferase [General function prediction only];


Pssm-ID: 443683  Cd Length: 372  Bit Score: 129.60  E-value: 6.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  16 PTTWRYIASDKRDLRIDFMRGIALVMMVVAHTeVMSIFNIFTWERFGLVTGAEGFVILSGFMLGMLNRVRLQKAVLLTIS 95
Cdd:COG4645    3 APAPAAPAPMGRDLRLDFFRGLALVFIFINHI-PGNVLERLTHRNFGFSDAAEGFVFLSGYAAALAYGRRFARGGFLAAT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  96 WGLYLRAWK--------IYRINIIIILSFLLLGYLPFINVFEVTHFTDRYSGTTWSLypVTPQIKETWFNI----VLYLQ 163
Cdd:COG4645   82 ARILRRAWQlyvahialFVLALALIALLALLFGNPDYLEELNLGPLLADPLGALLGL--LLLTYQPGYFDIlplyIVLLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946 164 IGPhqtqilglyifllllsplFLGMLQKGYVYWLLGLSLLVY--GGWQMWPVRATPSQFEFAFPLLAWQFIFVLGMCSGW 241
Cdd:COG4645  160 LAP------------------LLLWLARRRPWLVLALSVALWlaAQLFGLNLPAYPDGGGWFFNPFAWQLLFVLGLVLGL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946 242 Y-KEDLISFARTPAGKVVLVALVIIALLLGFIAQNHTNPFMPPAllmhslspedfnAFYHTWAAKNGLGPVRVLNDICLM 320
Cdd:COG4645  222 GrARGRRLVPRSRWLVWLALAYLLFSLVLVLFPFWWLVPALLWL------------PALLPLFDKTNLSPLRLLHFLALA 289

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489958946 321 VTVYLVLTWCWLPLYRLAGWFLIPLGQHSLYTFILHVYVVFLVsQFVTFDLWRqDWIVNTFIHAAALGVLWLMAKY 396
Cdd:COG4645  290 YLVAWLLPAGWRALRSRLLRPLILLGRHSLPVFCAGVVLSLAG-QIVLDVTGG-GPLLQTAVNLAGIALLLAVAYL 363
OpgC_C pfam10129
OpgC protein; This domain, found in various hypothetical and OpgC prokaryotic proteins. It is ...
 27-396 3.67e-32

OpgC protein; This domain, found in various hypothetical and OpgC prokaryotic proteins. It is likely to act as an acyltransferase enzyme.


Pssm-ID: 431075  Cd Length: 358  Bit Score: 124.64  E-value: 3.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946   27 RDLRIDFMRGIALVMMVVAHTeVMSIFNIFTWERFGLVTGAEGFVILSGFMLGM--LNRVRLQKAVLLTISwgLYLRAWK 104
Cdd:pfam10129   1 RDLRLDFFRGLALVFIFVDHI-PGNVLSWLTLRNFGFSDAAEVFVFLSGYAAGMayGRAMARRGWLAAAAR--ILRRAWQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  105 IYRINIIIILSFLLLGYLPFINVFEvthfTDRYSGTTWSLYPVTPQikETWFNIVLyLQIGPHQTQILGLYIFLLLLSPL 184
Cdd:pfam10129  78 LYVAHIALFVLVLALIALLALLFDN----PDYIDEFNLAPLLAQPL--ETLVGILL-LRYQPGYLDILPLYVVLLLLFPL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  185 FLGMLQKGyVYWLLGLSLLVYGGWQM--WPVRATPSQFEFAFPLLAWQFIFVLGMCSGWYKEDLISFARTPAGKVVL-VA 261
Cdd:pfam10129 151 ILWLALRG-PWLVLALSVLLWALAQLfgWNLPAYPSGGGWYFNPFAWQLLFVLGLWCGAGGRTGRRPLPGSRWLVWLaAA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958946  262 LVIIALLLGFIAQNHTNPFMPPALLMHSLSPEDfnafyhtwaaKNGLGPVRVLNDICLMVTVYLVLTWCWLPLYRLAGWF 341
Cdd:pfam10129 230 YLLFALVLTLAWLWPLLAALLPEALPQALYPID----------KTNLAPLRLLHFLALAYLVARLVPAGWRGLRRRWLRP 299

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489958946  342 LIPLGQHSLYTFILHVYVVFLVsQFVTFDLwRQDWIVNTFIHAAALGVLWLMAKY 396
Cdd:pfam10129 300 LILLGRHSLPVFCVGVVLSFLG-HSLLDTT-GGGLWMQLAVSAVGIALLAAVAYL 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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