|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
14-468 |
3.71e-140 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 411.05 E-value: 3.71e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:PRK10504 13 WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:PRK10504 93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSsgMELFGEK---IVATWLAlAVILSGILLFLLYIRHARRHP 250
Cdd:PRK10504 173 VGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLT--LALDGSKglgLSPLAIA-GLVAVGVVALLLYLLHARNNN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 251 TPLISLSLFNTRTFSVGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKT 330
Cdd:PRK10504 250 RALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 331 LVGVTIFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVS 410
Cdd:PRK10504 330 LVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIA 409
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489959096 411 AAVLRFYE----GFDGTNTVEQFHYTFITMGALTVVSAVVFMLLKPKDGRNLIKERHKEKAK 468
Cdd:PRK10504 410 GLLLGLFGqqhvSVDSGATHTVFMYTYLCMALIIALPALIFARVPNDTHQNVAISRRKRSAQ 471
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
16-451 |
1.48e-100 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 306.42 E-value: 1.48e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 16 AAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACAL 95
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 96 STSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIG 175
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 176 VAGLIYArkympnfttprrsfdmggfflfglslvlfssgmelfgekivatwlalavilsgillfllyirharrhptPLIS 255
Cdd:cd17503 161 ILALLLA---------------------------------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 256 LSLFNTRTFSVGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVT 335
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 336 IFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAVLR 415
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 489959096 416 FYEGFDGTNTVEQ-------------FHYTFITMGALTVVSAVVFMLLK 451
Cdd:cd17503 332 NRTQFHHSRLSELlaqqvqkqaliiaFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
18-435 |
1.15e-66 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 221.87 E-value: 1.15e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 18 MAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALST 97
Cdd:TIGR00711 9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 98 SLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVA 177
Cdd:TIGR00711 89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 178 GLIYARKYMPNFTTP-RRSFDMGGFFLFGLSLVLFSSGMELFGEKivaTWLALAVILS----GILLFLLYIRHARRHPTP 252
Cdd:TIGR00711 169 VVVVAFFILPRDKPAaSENFDFLGLLLLSVGLGSLLYGLSEGPER---GWFDSNEILIlsitGLVAIIAFVVWELTDDNP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 253 LISLSLFNTRTFSVGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTlv 332
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKL-- 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 333 gVTIFIGLMIAQFSLQSAAL----PIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVA 408
Cdd:TIGR00711 324 -VTIGLILYAVGFYWRAFTFtpdtPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
|
410 420
....*....|....*....|....*..
gi 489959096 409 VSAAVLRFYegfdgtntvEQFHYTFIT 435
Cdd:TIGR00711 403 LITTILTNR---------TQFHHSQLT 420
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-451 |
1.01e-55 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 189.69 E-value: 1.01e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 17 AMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALS 96
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 97 TSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGV 176
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 177 AGLIYArkympnfttprrsfdmggfflfglslvlfssgmelfgekivatwlalavilsgillfllyirharrhptplisl 256
Cdd:cd17321 162 VALLLA-------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 257 slfntRTFSVGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTI 336
Cdd:cd17321 168 -----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 337 FIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAVL-- 414
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLta 322
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489959096 415 -----------RFYEGFDGTNTVEQFHYTFITMGALTVVSAVVFMLLK 451
Cdd:cd17321 323 glsanlgdsgvAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-405 |
5.09e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 150.12 E-value: 5.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 6 ARSMAGLPWIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTL 85
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 86 FTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWH 165
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 166 WIFLINIPIGVAGLIYARKYMPNFTTPRRSFDMGGFFlfglslvlfssgmelfgekivatwlalavilsgillfllyirh 245
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR------------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 246 arrhptplislSLFNTRTFSVGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWF 325
Cdd:COG2814 202 -----------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 326 GYRKTLVGVTIFIGLMIAQFSLqsaALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISL 405
Cdd:COG2814 271 GRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-451 |
2.03e-36 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 137.31 E-value: 2.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 18 MAFFMQALDATILNTALPAIAQSLNRSPLaMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALST 97
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 98 SLTELVIFRVLQGIGGAMMMPVARLALLRAYP---RSELLPVLNFVTMpglVGPILGPVLGGVLVTWASWHWIFLINIPI 174
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPpreRGKYQGYIGAVFG---IASVAGPLIGGAFTDHLSWRWCFYINLPI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 175 gvagliyarkympnfttprrsfdmGGFFLFGLSLVLFSSgmelfgekivatwlALAVILSGILLFLLYirharrhptpli 254
Cdd:cd17502 159 ------------------------GGLALALLRTILLSS--------------IFGFLFGGALFGLIY------------ 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 255 slslfntrtfsvgiagniasrlgtgcvpfLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVL-RWFGYRKTLVG 333
Cdd:cd17502 189 -----------------------------YLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALIsKTGRYKPLIVI 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 334 VTIFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAvsaav 413
Cdd:cd17502 240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA----- 314
|
410 420 430
....*....|....*....|....*....|....*...
gi 489959096 414 lrfyegfdgtntveqFHYTFITMGALTVVSAVVFMLLK 451
Cdd:cd17502 315 ---------------ITDVFLVALALAALAFLLSLFLP 337
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-289 |
2.47e-36 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 135.71 E-value: 2.47e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 1 MTEKKARSMAGLPWIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFM 80
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 81 LAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVT 160
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 161 WASWHWIFLINIPIGVAGLIYARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFL 240
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489959096 241 LYIRHARRHPTPLISLSLFNTRTFSVGIAGNIASRLGTGCVPFLMPLML 289
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-451 |
2.13e-29 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 118.45 E-value: 2.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 17 AMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALS 96
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 97 TSLTELVIFRVLQGIGGAmMMPVArLALLRAYPRSELLPV-LNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIG 175
Cdd:cd17504 82 PNLPVLIAGRALQGIGGA-VFPLA-FALVREEFPPERVPVaQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 176 VAGLIYArkympnfttprrsfdmggfflfglslvlfssgmelfgekivatwlalavilsgillfllyirharrhptPLIS 255
Cdd:cd17504 160 VLLAALV---------------------------------------------------------------------PLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 256 LSLFNTRTFSVGIAGNIASRLGTGCVPFLMPLMLQ----VGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTL 331
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 332 VgvtifIGLMIAQFSLQSAAL---PIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVA 408
Cdd:cd17504 251 L-----IGLVISAVGLLLLALlhsSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPA 325
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 489959096 409 VSAAVLRFYEGFDGTNTV---EQFHYTFITMGALTVVSAVVFMLLK 451
Cdd:cd17504 326 IAGAILTTYTVSITSGGVpteGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-406 |
5.86e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.97 E-value: 5.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 17 AMAFFMQALDATILNTALP-AIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACAL 95
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 96 STSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIG 175
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 176 VAGLIYARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSSGmelfgekiVATWLALAVILSGILLFLLYirharrhptplis 255
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD--------PVLWLLLALLLFGFAFFGLL------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 256 lslfntrtfsvgiagniasrlgtgcvpFLMPLMLQVgFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVT 335
Cdd:pfam07690 221 ---------------------------TYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959096 336 IFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLG 406
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-411 |
1.96e-26 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 110.36 E-value: 1.96e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 12 LPWIAAMAFFMQaLDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSL 91
Cdd:cd17320 1 LLLLALLVALGP-LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 92 ACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLIN 171
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 172 IPIGVAGLIYARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSSGMELFGekivatwLALAVILSGILLFLlyirharrhpt 251
Cdd:cd17320 160 ALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYA-------LALGLSFAGLFAYL----------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 252 plislslfntrtfsvgiagniasrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTL 331
Cdd:cd17320 222 -------------------------------AAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 332 -VGVTIFIGLMIAQFSLQSA-ALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDEnASSGNSVLAVTQQLSISLGVAV 409
Cdd:cd17320 271 rLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHV-AGTASALLGFLQFLIGALAGAL 349
|
..
gi 489959096 410 SA 411
Cdd:cd17320 350 VG 351
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
24-417 |
2.38e-26 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 111.74 E-value: 2.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 24 ALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELV 103
Cdd:PRK14995 19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 104 IFRVLQGIGGAMMMPVA----RLALLRAYPRSELLPVLNFVtmpGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGL 179
Cdd:PRK14995 99 ATRALLAIGAAMIVPATlagiRATFTEEKQRNMALGVWAAV---GSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVM 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 180 IYARKYMPNFTTPRR---SFDMGGFFLFGLSLVLFSSGMELFGEkiVATWLALAVILSGILLFLLYIRHARRHPTPLISL 256
Cdd:PRK14995 176 GLTARYVPRQAGRRDqplNLGHALMLIVAILLLVYSAKTALKGF--LSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 257 SLFNTRTFSVGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKT-----L 331
Cdd:PRK14995 254 RLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVatggmA 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 332 VGVTIFIGLMIAQFSLQSAALPIWMLIlplfvLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSA 411
Cdd:PRK14995 334 LSALSFYGLAMTDFSTQQWQAWGLMAL-----LGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFG 408
|
....*..
gi 489959096 412 AVL-RFY 417
Cdd:PRK14995 409 LLLsRSY 415
|
|
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
21-447 |
1.38e-23 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 102.74 E-value: 1.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 21 FMQALDATILNTALPAIAQSLN-RSPLAMQSAIisYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSL 99
Cdd:NF040895 16 FMAAIETSIISLALPTIKEDLNaGSSISLVFTV--YFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSETF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 100 TELVIFRVLQGIGGAMMMPVARLALLRAYPrselLPvLNFVTMpGLVGP------ILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:NF040895 94 TMLIISRIIQGLGAGVMMSLSQIVPKLAFE----IP-LRYKIM-GIVGSvwgissIIGPLLGGGILEFATWHWLFFINIP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYARKYMpNF----TTPRRSFDMGGFFLFGLSLVLFSSGMELFGekivATWLALAVILSGILLFLLYIRHARRH 249
Cdd:NF040895 168 IAIIAIILVIFTF-HFpeeeTTSKTKFDVKGLTLFYIFIALLMFAVLNQG----HLWLNIISFILAIVVFFLLFKVEKKV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 250 PTPLISLSLFNTRTFSVGIAGNIASRLGTGCVPFlMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGyRK 329
Cdd:NF040895 243 KNPFLPVKEFNKSIILVFFTDFLIAMMLMGYNLY-IPIYLQEHLGLSPLQSGLVIFPLSVAWLILNFNLAKIEAKLT-RK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 330 TLVGVTIFIGLMIAQFSLQSAALPIwMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAV 409
Cdd:NF040895 321 GLYIGAFTLLIVCSILILFGLKLPL-LIAFALILAGLSFGTVYTKDSVIVQEETSPSNMKKMMSFYTLTKNLGSSIGSTI 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 489959096 410 SAAVLRFYEGFDGTNTVEQFHYTFITMGALTVVSAVVF 447
Cdd:NF040895 400 MGYIYALQVGLFGLSIQNILALIIIILIILIILWSTLY 437
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
15-446 |
2.13e-22 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 98.10 E-value: 2.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACA 94
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 95 LSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLP-VLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInip 173
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 igvagliyarkympnfttprrsFDMGGFFLFGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFLLYIRHArrhpTPL 253
Cdd:cd17476 159 ----------------------LAILAAIVAVAAIFWTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGY----SPL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 254 ISlSLFNTRTFSVGIAGNIASRLGTGCVPflmplmlqvgfgyPALIAGCMMAPTAMGSILAKSTVTQVLRWfgyrktlvg 333
Cdd:cd17476 213 LT-SARFIPMAIGGVLAAITVGFLIARLP-------------PSYIMAISMVAFLVGPILFATMPVHQTYW--------- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 334 vtifiglmiaqfslqsaALPIWMLILPLFvlGMAMStqFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:cd17476 270 -----------------AQAFPAMIVAPF--GMDFS--FPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTV 328
|
410 420 430
....*....|....*....|....*....|...
gi 489959096 414 LrFYEGFDGTNTVEQFHYTFITMGALTVVSAVV 446
Cdd:cd17476 329 E-TSVNEDGADLLKGYRAAWYLGIGLAALGLLI 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-450 |
3.94e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 97.64 E-value: 3.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWaSWHWIFLINIP 173
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYARKYMPNFTTPRRSFDMGGFFLFGlslvlfssgmelfgeKIVATWLALAVILSGILLFLLYirharrhptpl 253
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLK---------------KALRGRGLLTFLVSAFLYFFLY----------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 254 islslfntrtfsvgiagniasrlgtGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRW-FGYRKTLV 332
Cdd:cd17474 215 -------------------------FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILV 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 333 GVTIfigLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAA 412
Cdd:cd17474 270 IGLL---LYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL 346
|
410 420 430
....*....|....*....|....*....|....*...
gi 489959096 413 VLRFYegfdgtntveQFHYTFITMGALTVVSAVVFMLL 450
Cdd:cd17474 347 LLEIF----------GLSAPFLVGAAIALAAAVLLALL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-456 |
1.03e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.40 E-value: 1.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInip 173
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYArkympnfttprrsfdmggfflfglslvlfssgmelfgekIVATWLALAVILSGILLFLLYIrharrhptpl 253
Cdd:COG2271 170 LGLPGLLLA---------------------------------------LLRFWLLALAYFLVYFALYGFL---------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 254 islslfntrtfsvgiagniasrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVG 333
Cdd:COG2271 201 -----------------------------TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 334 VTIFIGLMIAqFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:COG2271 252 AIGLLLAALA-LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 489959096 414 LRFYegfdgtntveQFHYTFITMGALTVVSAVVFMLLKPKDGR 456
Cdd:COG2271 331 LDAT----------GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-451 |
1.14e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.25 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 17 AMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALS 96
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 97 TSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGV 176
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 177 AGLIYARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSSGmelfgekivatwlalAVILSGILLFLLYIRHARRHPTplisl 256
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDR---------------RLLALFLAIFVLAFAFGALEPF----- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 257 slfntrtfsvgiagniasrlgtgcvpflMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTI 336
Cdd:cd17325 222 ----------------------------LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 337 FIGLMIAQFSLQSAalpIWMLILPLFVLGMAMSTQFTSMNTItLADLTDENA-SSGNSVLAVTQQLSISLGVAVSAAVLR 415
Cdd:cd17325 274 LSAVALLLLPLATS---FWLLLLLLALLGLGLGLVFPATLAL-LADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
410 420 430
....*....|....*....|....*....|....*.
gi 489959096 416 FYegfdgtntveQFHYTFITMGALTVVSAVVFMLLK 451
Cdd:cd17325 350 AF----------GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
33-450 |
3.45e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.09 E-value: 3.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 33 ALPAIAQSLNRSPLAMQSAIIS-YTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGI 111
Cdd:cd17473 21 ALPAIAQHFVPNSELLVPLLLTlPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 112 GGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWaSWHWIFLI---NIPIGVAGLIYARKYMPN 188
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVyllALPVLILVLLFLPEPARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 189 FTTPRRSfdmggfflfglslvlfSSGMELFGEKIVATWLALAVILSGILLFllyirharrhptplislslfntrtfsvgi 268
Cdd:cd17473 180 SKSAASP----------------GAATAAALPWKRVLPIYFLAFLAMLLFY----------------------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 269 agniasrlgtgCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVgvtIFIGLMIAQFSLQ 348
Cdd:cd17473 215 -----------VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA---IGFALMALGFLLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 349 SAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLavtqQLSISLGVAVSAAVLRFYEgfdgtNTVEQ 428
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV----TSAFFLGQFLSPLVLGPLV-----NLTGG 351
|
410 420
....*....|....*....|..
gi 489959096 429 FHYTFITMGALTVVSAVVFMLL 450
Cdd:cd17473 352 LSGAFLILGVLALVLAIVLLLL 373
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-180 |
6.49e-18 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 85.35 E-value: 6.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 33 ALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIG 112
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489959096 113 GAMMMPVARlALLR-AYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInipIGVAGLI 180
Cdd:PRK11102 93 AAAASVVIN-ALMRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAIL 157
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-187 |
7.91e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 80.00 E-value: 7.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 52 IISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRS 131
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 489959096 132 ELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLIYARKYMP 187
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
14-177 |
1.27e-16 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 81.28 E-value: 1.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:TIGR00710 8 LLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:TIGR00710 88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167
|
....
gi 489959096 174 IGVA 177
Cdd:TIGR00710 168 AGIL 171
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-414 |
2.32e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 80.29 E-value: 2.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYARKYMPNFTTPRRSfdmggfflfglSLVLFSSGMELFGEKIVAtWLALAVILSGILLFLLYirharrhptpl 253
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPG-----------SLGLLSSLLLLLRNPRLR-LAYLITFLLFGGFFALY----------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 254 islslfntrtfsvgiagniasrlgtgcvPFLMPLMLQVGFGYPALIAGCMMApTAMGSILAKSTVTQVLRWFGYRKTLVG 333
Cdd:cd17324 219 ----------------------------TYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLIA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 334 vtiFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTItLADLTDENASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:cd17324 270 ---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALGGLV 345
|
.
gi 489959096 414 L 414
Cdd:cd17324 346 L 346
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-456 |
1.68e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.00 E-value: 1.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYARKYMPNftTPRrsfdmggfFLFGLSLVLFSSGMELFGEKivATWlalavilsgiLLFLLYIrharrhptpl 253
Cdd:COG2223 168 LLLVVAVLAWLFLRD--PPA--------GAAAAAKASLRDQLEALRDP--RFW----------LLSLLYF---------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 254 islslfntRTFSVGIAGNiasrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVG 333
Cdd:COG2223 216 --------GTFGSFIGFS-----------SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 334 VtiFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:COG2223 277 V--FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 489959096 414 lrfyegFDGTNTveqFHYTFITMGALTVVSAVVFMLLKPKDGR 456
Cdd:COG2223 355 ------LDATGS---YTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-415 |
1.95e-15 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 78.44 E-value: 1.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQsAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACA 94
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTW-ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 95 LSTSLTELVIFRVLQGIGGAM--MMPVARLALLRAYPRSELLPVLNFVTMPGLVgpiLGPVLGGVLV--TWASWHWIFLI 170
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTqgLGAAVASELVPNKYRGLVQGVVNLVASPGSA---LGPLIAGALVeaNAAGWRWIFYI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 171 NIPIGVAGLI----------YARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSSGMELFGEkiVATWLALAVI----LSGI 236
Cdd:cd06179 158 NAIFNALALIllfffyhpppRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGN--PYPWSSAHVIaplvIGGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 237 LLFLLYIRHAR-RHPTPLISLSLFNTRTF-SVGIAGNIASRLGTGCVPFLmPLMLQVGFGYPALIAGCMMAPTAMGSILA 314
Cdd:cd06179 236 LLIAFGLYEWKgTKDGLLPPRLLFRGRNFaLILIVAFVEGMIFYSLNIFW-PQQISLLFTTDPLKAGLYQLPFGLGTLFG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 315 KSTVTQVLRWFGYRKTL--VGVTIFIGLMIAQFSLQ--SAALPIWMLILPLFVLGmamSTQFTSMNTITLAdLTDENASS 390
Cdd:cd06179 315 AILAGLLLTKIKHIKWQlvAGFVLFTAFLALLALITpdNKALAIAFSVLAGIGIG---GPLVLAIVIVQLS-VPPEDIGT 390
|
410 420
....*....|....*....|....*
gi 489959096 391 GNSVLAVTQQLSISLGVAVSAAVLR 415
Cdd:cd06179 391 ASGLLGSARALGGAVGTAIFTSILS 415
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-182 |
4.08e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 76.46 E-value: 4.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFM---QALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGS 90
Cdd:cd17319 3 RIIPLLFLAyviNYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 91 LACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170
....*....|..
gi 489959096 171 nipIGVAGLIYA 182
Cdd:cd17319 163 ---EGLLGLLLA 171
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
14-180 |
1.97e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 74.53 E-value: 1.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
....*..
gi 489959096 174 IGVAGLI 180
Cdd:cd17323 162 ISGFCLI 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-447 |
1.21e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.07 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 16 AAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACAL 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 96 STSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTW--ASWHWIFLINIP 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 174 IGVAGLIYARKYMPNFTTPRRSfdmggfflfGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFLLYIrharrhptpl 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARA---------KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS---------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 254 islslfntrtfsvgiagniasrlgtgcVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVG 333
Cdd:cd06174 222 ---------------------------FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 334 vtIFIGLMIAQFSLQSAALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAV 413
Cdd:cd06174 275 --IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
410 420 430
....*....|....*....|....*....|....
gi 489959096 414 LrfyegfdgtNTVEQFHYTFITMGALTVVSAVVF 447
Cdd:cd06174 353 L---------AATFGLTGAFLVLAVLLLLAAILL 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-170 |
1.35e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.39 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSaIISYTLTVAMLIP-VSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:TIGR00895 21 LSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGF-LFSAGLIGMAFGAlFFGPLADRIGRRRVLLWSILLFSVFTLLC 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-450 |
4.46e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 70.72 E-value: 4.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 28 TILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACAL-----STSLTEL 102
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 103 VIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLIN-IPIGVAGLIY 181
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINaLSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 182 ARKYMPNFTTPRRSFDmggfflfglslvLFSSGMELFGEKIVATWLALAVILSGILLFLLYirharrhptplislslfnt 261
Cdd:cd06173 176 LFIRRPPPAAPGESSS------------LLLRDLREGLRYLRRSPLLRLLLLALALFALLG------------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 262 rtfsvgiagniasrlgtGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTIFIGLM 341
Cdd:cd06173 225 -----------------GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 342 IAQFSLqsaALPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAVLRFYEGfd 421
Cdd:cd06173 288 LLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL-- 362
|
410 420
....*....|....*....|....*....
gi 489959096 422 gtntveqfHYTFITMGALTVVSAVVFMLL 450
Cdd:cd06173 363 --------SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-312 |
2.13e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.40 E-value: 2.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIP--VSGWLADRFGTRKVFMLAVTLFTLGSLA 92
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGalLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 93 CALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWAS----WHWIF 168
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 169 LINIPIGVAGLIYARK--------------------YMPNFTTPRRSFD------MGGFFLFGLSLVLFSSG--MELFGE 220
Cdd:cd17316 163 LIGALPALLALLLRRRtlllillwffisfgyyglttFLPTYLQTVLGLSpatsslYLLLISLGALVGALIAGllSDRIGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 221 KIvatWLALAVILSGILLFLLYIRHARRHPTPLISLSLF---------------------NTRTFSVGIAGNIaSRLGTG 279
Cdd:cd17316 243 KK---TLVIGLILSGILALPLFYLLSGSPTLLLLLLFILsffvggvwgalyaylaelfptEVRATGVGLSYNL-GRLGGG 318
|
330 340 350
....*....|....*....|....*....|....*
gi 489959096 280 CVPFLMPLMLQVGFGY--PALIAGCMMAPTAMGSI 312
Cdd:cd17316 319 GAPPLIALLLASTGGTgvPALILALLAIVALIVAL 353
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
28-183 |
2.23e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 68.40 E-value: 2.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 28 TILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRV 107
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 108 LQGIG----GAMMMPVARlallRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWH--WIFLINIPIGVAGLIY 181
Cdd:PRK11652 105 IQGLGtgvgGVMARTLPR----DLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRacYLFLLLLGAGVTFSMA 180
|
..
gi 489959096 182 AR 183
Cdd:PRK11652 181 RW 182
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-182 |
2.51e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 68.00 E-value: 2.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 25 LDATILNTALPAIAQSLNRSPlAMQSAIISYTLtVAMLIP--VSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTEL 102
Cdd:cd17365 13 FDLAVMGFVAPALAQDWGLSP-AQLGPVGSAAL-FGMAIGalLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 103 VIFRVLQGIGGAMMMPVArLALLRAYPRSELLPVLNFVTMPGL-VGPILGPVLGGVLVTWASWHWIFLINipiGVAGLIY 181
Cdd:cd17365 91 ALLRFLTGLGLGAAMPNA-ITLVSEYAPARRRSLAVTLMFCGYpLGAALGGFLAAALIPAFGWRSVFLLG---GVPPLIL 166
|
.
gi 489959096 182 A 182
Cdd:cd17365 167 L 167
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
7-397 |
1.16e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.03 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 7 RSMAGLPWIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLF 86
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 87 TLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSE--LLPVLNFVTMpglVGPILGPVLGGVLVTW--- 161
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAasRLNLLHAFFS---LGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 162 ASWHWIFLIN-IPIGVAGLIYARKYMPNFTTPrrsfdmggfflfglslvlfSSGMELFGEKIVATWLALAVILSGILLFl 240
Cdd:COG0738 161 LSWHLPYLILaVLLLLLALLFLRSKLPEIEEE-------------------EEEAAGSAASLKSLLKNPRLLLGGLAIF- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 241 lyirharrhptplislslfntrtFSVGIAGNIASrlgtgcvpfLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQ 320
Cdd:COG0738 221 -----------------------LYVGAEGAIGD---------WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489959096 321 VLRWFGYRKTLVGVTIFIGLMIAQFSLQSAAlpiWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAV 397
Cdd:COG0738 269 LLKRFGPVRLLRLSALLAAVGLLLALLAPGP---WLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
33-194 |
6.21e-11 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 64.19 E-value: 6.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 33 ALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIG 112
Cdd:PRK15402 35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 113 GAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLIYARKYMPNFTTP 192
Cdd:PRK15402 115 LCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGR 194
|
..
gi 489959096 193 RR 194
Cdd:PRK15402 195 VG 196
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-180 |
9.94e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.00 E-value: 9.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 18 MAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALST 97
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 98 SLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVA 177
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
...
gi 489959096 178 GLI 180
Cdd:cd17489 163 ALL 165
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
32-168 |
3.81e-10 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 61.58 E-value: 3.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 32 TALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGI 111
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959096 112 GGAMMMPVArLALLR----AYPRSELLPVLNFVTmpgLVGPILGPVLGGVLVTWASWHWIF 168
Cdd:PRK10473 104 GAGCCYVVA-FAILRdtldDRRRAKVLSLLNGIT---CIIPVLAPVLGHLIMLKFPWQSLF 160
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-182 |
4.65e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.05 E-value: 4.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLnrspLAMQSAIISYTLTVAMLI-----PVSGWLADRFGTRKVFMLAVTLFTL 88
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAEL----GGLSPAQIGLLFGAQGLAsalsqPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 89 GSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIF 168
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....
gi 489959096 169 LINIPIGVAGLIYA 182
Cdd:cd17325 358 LAAAALLLLAAVLF 371
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
15-112 |
7.35e-10 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 60.66 E-value: 7.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACA 94
Cdd:cd17359 5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
|
90
....*....|....*...
gi 489959096 95 LSTSLTELVIFRVLQGIG 112
Cdd:cd17359 85 FSPNFTIFIIARIIGGLA 102
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-177 |
7.45e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 60.71 E-value: 7.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSP----LAMQSAIISYTLtvamLIPVSGWLADRFGTRKVFMLAVTLFTLG 89
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDslagLLQTVFIISYMV----LSPIFGYLGDRYNRKWILAVGILIWSAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 90 SLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWA-SWHWIF 168
Cdd:cd17328 78 TLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAF 157
|
....*....
gi 489959096 169 LINIPIGVA 177
Cdd:cd17328 158 RVTGVLGVL 166
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
67-180 |
1.48e-09 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 59.84 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 67 GWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLV 146
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110
....*....|....*....|....*....|....
gi 489959096 147 GPILGPVLGGVLVTWASWHWIFLInipIGVAGLI 180
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAI---IAVMGLI 182
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
18-182 |
3.88e-09 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 58.50 E-value: 3.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 18 MAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALST 97
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 98 SLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSE-LLPVLNFVTMPGLVGPILGPVLGGVLVTWaSWHWIFLInipIGV 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASErATAVSIFNSAQGLGGIIGGPLVGWILIHF-SWQWAFII---EGV 156
|
....*.
gi 489959096 177 AGLIYA 182
Cdd:TIGR00893 157 LGIIWG 162
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
8-417 |
9.19e-09 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 57.75 E-value: 9.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 8 SMAGLPWIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQsaiisYTLTVAMLIPVSGWLADRFGtRKVFMLAVTLFT 87
Cdd:pfam06609 45 SFAAFSLNVCATYFVLQASASALPNILQDIGQSENQGLFSTL-----WTMGQAVSILMMGRLTDRFG-RRPFVIATHIIG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 88 L-----GSLACALSTSLTELVIFRVLQGIGGAMMMPVARLAllraYPRSELLPVLnFVTMPGLVGPILGPVLGGVLVTWA 162
Cdd:pfam06609 119 LvgaivGCTANKFNTLLAAMTLLGVAAGPAGASPLFIGELM----SNKTKFLGLL-IVSAPTIAMNGAGPYFGQRLAIQG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 163 SWHWIFLINIPIGVAG--LIYARKYMPNFT------TPRR----SFDMGGFFLFGLSLVLFSSGMElFGEKIVATWLALA 230
Cdd:pfam06609 194 NWRWIFYIYIIMSAIAvlLIIIWYHPPSFAqlhgkkARKRdelaKLDWIGIFLVIAGTSLFLLGVS-WGGKPNNPWNSAK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 231 VI------LSGILLFLLYIRHARRHpTPLISLSLF-NTRTFSVGIAgnIASRLGTG--CVPFLMPLMLQVGFGYP----- 296
Cdd:pfam06609 273 IIglissgAGSLVIFALYEVFGKPE-QPIIPPALFkDTRGFVCILI--ISSIMGAMhlCLTIIYPQQVINIFGSSlknwe 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 297 --ALIAGCMMAPTAMGSILAKSTVTQV--LRWfgyrKTLVG---VTIFIGLMiAQFSLQSAALPIWMLILPLFVLGMAMS 369
Cdd:pfam06609 350 etAWMSATASFGTGAGVMILGNLFHLIrhIRW----QILVGalwLTAFLGAM-SSINRDNKNAAIALSFFSGFVVAWAQD 424
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489959096 370 TQFTSMNTITladlTDENASSGNSVLAVTQQLSislGVAVSAAVLRFY 417
Cdd:pfam06609 425 ITMLLVQFIT----TDEDLGVAFAVVAAARPFA---GSIFTAAFISLY 465
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-182 |
1.09e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 17 AMAFFMQALDATILNTALPAIAQSLNRSpLAMQSAIIS-----YTLTVAmlipVSGWLADRFGTRKVFMLAVTLFtlgSL 91
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWS-KTDQGLVLSsffwgYALTQV----LGGYLADRFGGKKVLLLAVALW---SL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 92 ACAL-----STSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHW 166
Cdd:cd17380 77 ATLLtpllaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
170
....*....|....*.
gi 489959096 167 IFLInipIGVAGLIYA 182
Cdd:cd17380 157 VFYF---FGLLGLLWA 169
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-187 |
3.06e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 55.39 E-value: 3.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPlAMQSAIISYTLTVAMLIPV-SGWLADRFGTRKVFMLAVTLFTLGSLA 92
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDE-AEAGLLGTVTLAGGAIGGIlGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 93 CALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWAS----WHWIF 168
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLF 160
|
170
....*....|....*....
gi 489959096 169 LINIpIGVAGLIYARKYMP 187
Cdd:cd17371 161 LLGA-LPALLVLFIRRFVK 178
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
14-368 |
3.21e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 55.86 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQS----AIISYTLTVAMLipvsGWLADRFGTRKVFMLAVTLFTLG 89
Cdd:PRK03893 23 SAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASlisaAFISRWFGGLLL----GAMGDRYGRRLAMVISIVLFSVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 90 SLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFL 169
Cdd:PRK03893 99 TLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 170 INI-PIGVAglIYARKYMPN---------------------FTTPRRSFDMggfflfGLSLVLFSSGMELFGEKIVATWL 227
Cdd:PRK03893 179 IGIlPIIFA--LWLRKNLPEaedwkekhagkapvrtmvdilYRGEHRIINI------LLTLAAAAALWFCFAGNLQNAAI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 228 --ALAVILSGILLFLLYIRHARRHPTPL-ISLSLFNTRTFSVGIAGniasrlgtgcvpfLMPLMLQVGFGY-PALIAGCM 303
Cdd:PRK03893 251 vaVLGLLCAAIFISFMVQSSGKRWPTGVmLMVVVLFAFLYSWPIQA-------------LLPTYLKTDLGYdPHTVANVL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489959096 304 MAP---TAMGSILAKSTVTqvlrWFGYRKTLVgvtifIGLMIAQFslqsaalpiwmLILPLFVLGMAM 368
Cdd:PRK03893 318 FFSgfgAAVGCCVGGFLGD----WLGTRKAYV-----CSLLISQL-----------LIIPVFAIGGAN 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
64-281 |
8.44e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.16 E-value: 8.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 64 PVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMP 143
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 144 GLVGPILGPVLGGVLVTwASWHWIFLINIPI-GVAGLIYARKYMPNFTTPRRSFDMGG---------------------- 200
Cdd:cd17329 133 INLGVAIGPLLGGLLLL-YSFRLLFLAAAVLfLLAALVLLFLLPETRPKRRAAEKTEIlrgykivlrdrafllfllasfl 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 201 ----FFLFGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFLL--YIRHARRHPTPLISLSLFNTRTFSVGIAGNIAS 274
Cdd:cd17329 212 isliYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVarLVERFRLRKILMIGILLFAIGFAVLAFANTLAV 291
|
....*..
gi 489959096 275 RLGTGCV 281
Cdd:cd17329 292 LILAMIV 298
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
15-112 |
9.72e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 53.73 E-value: 9.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLA-MQSAIISYTLTVAMLIPV-SGWLADRFGTRKVFMLAVTLFTLGSLA 92
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTsLQGLVVSSLLLGAAIGSLfGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100
....*....|....*....|
gi 489959096 93 CALSTSLTELVIFRVLQGIG 112
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLG 100
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-180 |
1.11e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 53.74 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 33 ALPAIAQSLNRSPlamqsAIISYTLTV-----AMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRV 107
Cdd:PRK11043 28 AFKAIQADLQTSA-----SAVSASLSLflagfALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRF 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489959096 108 LQGIGgAMMMPVARLAL-LRAYPRSELLPVlnFVT-MPgLVG--PILGPVLGGVLVTWASWHWIFLINIPIGVAGLI 180
Cdd:PRK11043 103 VQAVG-VCSAAVIWQALvIDRYPAQKANRV--FATiMP-LVAlsPALAPLLGAWLLNHFGWQAIFATLFAITLLLIL 175
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
22-120 |
2.73e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 52.66 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 22 MQALDATILNTALPAIAQSLNRSPLAMQ---SAIISYTLTVAMLipvSGWLADRFGTRKVFMLAVTLFTLGSLACALSTS 98
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGwafSAGILGLLPGALL---GGRLADRIGRKRILIVSVALFGLFSLATAQAWD 102
|
90 100
....*....|....*....|....
gi 489959096 99 LTELVIFRVLQGI--GGAMMMPVA 120
Cdd:PRK11551 103 FPSLLVARLLTGVglGGALPNLIA 126
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
14-171 |
4.90e-07 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 52.06 E-value: 4.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMA----FFMQALDATILNTALPAiaqslnrSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKvFMLAVTLFTLG 89
Cdd:pfam05977 16 WIASLAsnlgTLMQDVAASWLMTSLSA-------SPLMVALVQAAATLPIFLLSIPAGALADNFDRRK-IMLAGQLLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 90 SLACALSTSLTE------LVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWAS 163
Cdd:pfam05977 88 VSTLLTLLAGLGllspwlLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFG 167
|
....*...
gi 489959096 164 WHWIFLIN 171
Cdd:pfam05977 168 PAFTFALN 175
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
15-119 |
6.52e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 51.12 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLA--MQSAIISYTLTVAMLIP-VSGWLADRFGTRKVFMLAVTLFTLGSL 91
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLStgWQELIVSSTVAGAAVGAaIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110
....*....|....*....|....*....|.
gi 489959096 92 ACALSTSLTELVIFRVLQGIG---GAMMMPV 119
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGvgiASMTVPL 111
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-170 |
1.99e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.96 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 13 PWIAAMAFFMQALDATILNTA---LPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLG 89
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 90 SLACALSTSLTELVI-FRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIF 168
Cdd:cd17355 82 LVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
..
gi 489959096 169 LI 170
Cdd:cd17355 162 LV 163
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-176 |
2.29e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 30 LNTALPAIAQS--LNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRV 107
Cdd:TIGR00881 14 FALAMPYLVEEigLSKTDLGLLLSSFSIAYGISKF--VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWA 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 108 LQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWA-SWHWIFLINIPIGV 176
Cdd:TIGR00881 92 LNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAI 161
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-347 |
3.14e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.11 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 52 IISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAmMMPVARLALLRAYPRS 131
Cdd:cd17330 40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 132 ELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLIYARKYMPNFTTPrrsfdMGGFFLFGLSLVLF 211
Cdd:cd17330 119 ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRL-----LLVYFLIALAFAGL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 212 SSGMELFG------EKIVATWLALAVILSGILLFLLYIRHARRHPTP----LISLSLFNTRTFSVGIAGN-----IASRL 276
Cdd:cd17330 194 ESVFSLFLkdrfgfSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGErkllRLGLLLAIIGLLLLPFASSvpllvLAAAI 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489959096 277 GTGCVPFLMPLML-----QVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTIFIGLMIAQFSL 347
Cdd:cd17330 274 LAFGTGIVFPALSallskSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-182 |
3.82e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.80 E-value: 3.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 64 PVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPvARLALLRAY-PRSELLPVLNFVTM 142
Cdd:cd17391 258 PRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLP-AINSLLAKItPKEVAGRIFGYNQS 336
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489959096 143 PGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLIYA 182
Cdd:cd17391 337 FQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-170 |
3.90e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.10 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 6 ARSMAGLPWIAAMAFFMQALDATILNTALPAIAQSLnRSPLAMQSAIISYTLTVAMLI-----PVSGWLADRFGTRKVFM 80
Cdd:COG2807 9 RRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEI-RADLGLSATQAGLLTTLPLLAfglfaPLAPRLARRFGLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 81 LAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRsELLPVLNFVTMPGLVGPILGPVLGGVLVT 160
Cdd:COG2807 88 LALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAA 166
|
170
....*....|
gi 489959096 161 WASWHWIFLI 170
Cdd:COG2807 167 ALGWRGALAV 176
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-188 |
4.77e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 48.75 E-value: 4.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 51 AIISYTLTVAML-IPVsGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIgGAMMMPVarLALLRAYP 129
Cdd:cd17472 37 ALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVV--MALLADLT 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489959096 130 RSE-------LLPVLNFVTMpgLVGPILGPVLGGVLvtwaSWHWIFLINIPIGVAGLIYARKYMPN 188
Cdd:cd17472 113 REEnrtkamaLIGASIGIAF--AISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVPD 172
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-180 |
5.09e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.42 E-value: 5.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 30 LNTALPAIAQS--LNRSPLAMQSAIISYTLTVAMLIpvSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRV 107
Cdd:cd17312 22 FSVAKPPIVEEigLSKDDLGIIGSAFLIAYAVGKFI--SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489959096 108 LQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLI 180
Cdd:cd17312 100 LNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAI 172
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
15-112 |
1.11e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 47.66 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVS-----GWLADRFGTRKVFMLAVTLFTLG 89
Cdd:cd17364 3 IAGMGFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIgqlffGFLGDRFGRKRVYGVELIIMIIG 82
|
90 100
....*....|....*....|....*....
gi 489959096 90 SLACALS------TSLTELVIFRVLQGIG 112
Cdd:cd17364 83 TILSALSpgstplGVMGWLIFFRFLLGIG 111
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-120 |
1.53e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
90 100
....*....|....*....|....*....
gi 489959096 94 ALS--TSLTELVIFRVLQGIGGAMMMPVA 120
Cdd:COG2211 312 FFLgpGNLWLLLVLAALAGIGLGAILVLP 340
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-181 |
1.91e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.86 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 12 LPWIAaMAFFMQALD-ATILNTALPAIAQSLNrsplaMQSAIISYTLTVAMLI-----PVSGWLADRFGTRKVFMLAVTL 85
Cdd:cd17327 7 LPLLC-ILYFLQYLDkSNISNAAVMGMKEDLK-----LVGNQYNWGNTVFYVGyiifeLPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 86 FTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLG-GVLV----- 159
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvg 160
|
170 180
....*....|....*....|....*.
gi 489959096 160 TWASWHWIFLI----NIPIGVAGLIY 181
Cdd:cd17327 161 GLAGWRWLFIIegliTIIIGLVIFFW 186
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
59-180 |
2.06e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.84 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 59 VAMLIPvSGWLADRFGTRKVFMLAV---TLFTLGSLACAlSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLP 135
Cdd:cd17318 70 ILTQIP-GGYLAEKYGAKRVLGYSIlitALLTLLTPLAA-RGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 489959096 136 VLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInipIGVAGLI 180
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI---FGGLGLL 189
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
64-220 |
5.26e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 45.30 E-value: 5.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 64 PVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMpVARLALLRAYPRSELLPVLNFVTMP 143
Cdd:cd17390 49 PLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRVLGRFNAA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 144 GLVGPILGPVLGGVLVTWASWHW--------IFLINipigvAGLIYArkympnftTPRRSFDMGGF-FLFGLSLVLFSSG 214
Cdd:cd17390 128 SSLGFILGPVVGGHLAETDGGFYyvallcsaIFILN-----AGLVWF--------LLSKLWDLLLVrFLMGFSVLLFRSN 194
|
....*.
gi 489959096 215 MELFGE 220
Cdd:cd17390 195 FSLYLE 200
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
55-259 |
7.80e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 55 YTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVA---RLALLRAYPRS 131
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfvlGMEIVGPKYRS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 132 EllpVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIflINIPigvaGLIYARKYMPnftTPRRSFDMgGFFLFGLSLVLF 211
Cdd:cd17317 114 F---VGILFGLFWALGYMLLALLAYLIRDWRWLQLA--ISLP----GLLFLLLLWW---LPRRTIIV-GLIWFVTSLVYY 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 489959096 212 S---SGMELFGEKIVATWLALAV-ILSGILLFLLYIRHARRhptPLISLSLF 259
Cdd:cd17317 181 GlslNSSNLGGNLYLNFFLSGLVeIPAYFLALLLLDRLGRR---WTLSGSLL 229
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
193-465 |
7.92e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 193 RRSFDMGG---FFLFGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFLL---YIRHARRHPTPLISL-SLFNTRTFS 265
Cdd:COG2211 152 RFAFAGLGgllASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGtkeRPVPEEEKVSLKESLkALLKNRPFL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 266 VGIAGNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTL-VGVTIFIGLMIAQ 344
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFiIGLLLAALGLLLL 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 345 FSLQSAALPIWMLILPLFVLGMAMstqFTSMNTITLADLTDE--------NASSGNSVLAVTQQLSISLGVAVSAAVLRF 416
Cdd:COG2211 312 FFLGPGNLWLLLVLAALAGIGLGA---ILVLPWAMLADVVDYdewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLAL 388
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 489959096 417 YeGFDGT-----NTVEQFHYTFITMGALTVVSAVVFMLLKPkdgrnLIKERHKE 465
Cdd:COG2211 389 F-GYVAGaaqspSALTGIRLLFFLLPAVLLLLAALLLLFYP-----LTRERHAE 436
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
14-229 |
9.62e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 44.56 E-value: 9.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLAC 93
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 94 ALSTSLTELVIFRVLQGIGGAMM---MPVARLALLRAYPRsellPVLNFVTMPGLVGPILGPVLGGVLVTW-ASWHWIFL 169
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALdvaMNAQGVAVERAYGR----PIMSSLHAMWSLGGLAGALLGAAAIGAgVSPGVHLL 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 170 INIPIGVAGLIYARKYMP----------NFTTPRRSFDMGGFFLFGLSLVLFSSgmeLFGEKIVATWLAL 229
Cdd:cd17393 158 AAAVLLLLAALVAIRALLpgtgeaaedrPDGAGKPGFLLPNRLLLLLGLLALAA---ALAEGAAADWSAL 224
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
34-180 |
1.41e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.13 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 34 LPAIAQSLNRSPLAMQSAIISYTLTVAML-IPVsGWLADRFGTRKVFMLAVTLFT-LGSLACALSTSLTELVIFRVLQGI 111
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLrIPL-GILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959096 112 GGAM--MMPVARLALlraYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLI 180
Cdd:cd17490 98 AAATwvSFTVLYASY---FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFI 165
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-160 |
1.43e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.11 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPL---AMQSAIISYTLTVAMLI--PVSGWLADRFGTRKVFMLAVTLFTL 88
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTGFglgITEAGLLLLPGALVMLIagPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489959096 89 GSLACAL-STSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVT 160
Cdd:cd17504 260 GLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-187 |
3.66e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 29 ILNTALPAIAQSLNRSpLAMQSAIIS-YTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRV 107
Cdd:cd17478 14 FLPALLPLLIAKLGLS-YAQAGLLVSvFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 108 LQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMpGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGLIYARKYMP 187
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVG-GNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
15-245 |
4.50e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQAldatilntalpaiAQSLNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGTRKVFMLAVTLFTLGSLACA 94
Cdd:cd17475 15 IPALAPFLQE-------------DLHLSLAQVGLLLSALNLGVAVSML--PAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 95 LSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPI 174
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959096 175 GVAGLIYARKYMPNFTTPRRSFDMGGFFLFGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFLLYIRH 245
Cdd:cd17475 160 SILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLG 230
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
15-112 |
5.62e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.26 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPL----AMQSAIISYTLTVAMLIP-------VSGWLADRFGTRKVFMLAV 83
Cdd:pfam00083 4 VAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSksvsSLAALSVLSGLIVSIFSVgcfigslFAGKLGDRFGRKKSLLIAN 83
|
90 100 110
....*....|....*....|....*....|..
gi 489959096 84 TLFTLGSLACALST---SLTELVIFRVLQGIG 112
Cdd:pfam00083 84 VLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIG 115
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
65-211 |
7.82e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 7.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 65 VSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQG--IGGAMMMPVARLALLRAYPRSELLPVLN--FV 140
Cdd:cd17362 58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGvgIGLAMHAAPVYIAETSPSHIRGLLVSLKelFI 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959096 141 TMPGLVGPILGPVLGGVLvtwASWHWIFLINIPIGVAgLIYARKYMPnfTTPRRSFDMGGFFLFGLSLVLF 211
Cdd:cd17362 138 VLGILLGYVSGYAFADVV---GGWRYMYGLAAPPALL-LGIGMWFLP--PSPRWQGNYRKPLIIGLGLVLF 202
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
28-180 |
1.21e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.09 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 28 TILNTALPAIAQSLNRSPLAMQSAIIS-------YTLTVAMLI-------PVSGWLADRFGTRKVFMLAVTLFTLGSL-- 91
Cdd:cd17357 17 GVVNAPQEVFKEFINDTLVDRYGLNLSdseldllWSLIVSIFFiggaigsFISAFLANRFGRKNGLLISNALLVVSSLlm 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 92 ACALSTSLTELVIF-RVLQGIGGAMMMPVARLALLRAYPrSELLPVLNFVTMPGLVGPIL-GPVLG--GVLVTWASWHWI 167
Cdd:cd17357 97 FLSKSAKSPELLIFgRFLVGIACGLSTGFVPMYLQEISP-SELRGALGSLTQIGVTLGILlGQVFGlpSVLGTETLWPYL 175
|
170
....*....|...
gi 489959096 168 FLINIPIGVAGLI 180
Cdd:cd17357 176 LFFPGIPALLQLA 188
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-368 |
2.04e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 51 AIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQG-----IGGAMMMpVARLAll 125
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGvfsgyVPNATAL-IASQT-- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 126 rayPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWaswhwiflinipIGVagliyarkympnfttpRRSFDMGGFFLFG 205
Cdd:cd17391 118 ---PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADL------------FGI----------------RNVFFITGGLLFL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 206 LSLVLFSSGMELFGEKIVATWLALAVILSGIllfllyirharrhPTPLISLSLFNTrTFSVGIAGNIASRLGTGCVPFLM 285
Cdd:cd17391 167 AFLLTLFFVKEDFKPVEKKKMVSTKEVWNSV-------------PNPSLLISLFVT-TFIIQLANQSIEPILTLYIRQLM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 286 PLMLQVgfgypALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTIFIGLMiaqFSLQSAALPIWMLILPLFVLG 365
Cdd:cd17391 233 GDASNL-----AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL---YIPQAFVQTPWQLGILRFLLG 304
|
...
gi 489959096 366 MAM 368
Cdd:cd17391 305 LAT 307
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
7-180 |
2.24e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 40.29 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 7 RSMAGLPWIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMqSAIISYtLTVAMLIPV--SGWLADRFGTRKVFMLAVT 84
Cdd:PRK03699 3 SNRIKLTWISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSM-SNTFTF-LNAGILISIflNAWLMEIIPLKRQLIFGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 85 LFTLGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYP---RSELLPVLN-FVTMPGLVGPILGPVLggvLVT 160
Cdd:PRK03699 81 LMILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEgkqRGSRLLFTDsFFSMAGMIFPIIAAYL---LAR 157
|
170 180
....*....|....*....|
gi 489959096 161 WASWHWIFLInipIGVAGLI 180
Cdd:PRK03699 158 SIEWYWVYAC---IGLVYVA 174
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
15-112 |
2.28e-03 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 40.40 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 15 IAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYT-LTVAMLIP-------VSGWLADRFGTRKVFMLAVTLF 86
Cdd:TIGR00879 32 IAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWgLVVSIFLVggfigalFAGWLSDRFGRKKSLLIIALLF 111
|
90 100
....*....|....*....|....*....
gi 489959096 87 TLGSL---ACALSTSLTELVIFRVLQGIG 112
Cdd:TIGR00879 112 VIGAIlmgLAAFALSVEMLIVGRVLLGIG 140
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
14-398 |
2.43e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSlnrsPLAMQSAIISYTLTVAMLIPV-SGWLADRFGTRKVFMLAVTLFTLGSLA 92
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNL----NVADVSVIFSSQNAGYLIGSLlAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 93 CALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRS--ELLPVLNFVTMpglVGPILGPVLGGVLVTW-ASWHWIFL 169
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESsaTRLNVLHGFFG---LGALIGPLIATSLLTSeLSWSWAYL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 170 INIPIGVAGLIYARkympnfttprrsfdmgGFFLFGLSLVLFSSGMELFGEKIVATWLALAVILSGILLFLLYirharrh 249
Cdd:cd17333 155 IIGLIYLLLAILIL----------------LTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLY------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 250 ptplislslfntrtfsVGIAGNIASrlgtgcvpfLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRK 329
Cdd:cd17333 212 ----------------VGAETAFSS---------WVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT 266
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489959096 330 TLVGVTifIGLMIAQFSLQSAALPIWMLILpLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVT 398
Cdd:cd17333 267 LLVLSG--SGALLGLLILLLAPTLVVGLVA-TALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAG 332
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
49-450 |
2.89e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 49 QSAIISYTLTVAMLI--PVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVI-FRVLQGIGGAMMMPVARLALL 125
Cdd:cd17352 39 DIAWIGSLLLGVSLFsgPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 126 RaYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInipigVAGLIyarkympnfttprrsfdmggfflfg 205
Cdd:cd17352 119 Q-YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI-----LGGLC------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 206 LSLVLFSSGMELFGEKIVatwlaLAVILSGILLFLLYIrharrhpTPLISLSLFntrTFSVGIAGNIASrlgtgcvpFLM 285
Cdd:cd17352 168 LNLCVCGLLLRLLKDPTF-----VLLALGVSFAMLGFF-------VPFVYLPSY---AKSLGIDESDAA--------FLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 286 plmlqvgfgypALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTIFIGLMIAQFslqsaalpiWMLILPLFVLG 365
Cdd:cd17352 225 -----------SIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTY---------VGLIVFSVLFG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 366 MAMSTqFTSMNTITLADLTD-ENASSGNSVLAVTQQLSISLGVAVSAAVLrfyegfDGTNTveqFHYTFITMGALTVVSA 444
Cdd:cd17352 285 FCSGS-YSSLTPVILADLVGlEKLSNAYGLVLLFQGLAALVGPPIAGLLR------DYTGD---YDAAFYFCGACLLLSG 354
|
....*.
gi 489959096 445 VVFMLL 450
Cdd:cd17352 355 VLLFLL 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-180 |
3.76e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.48 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAI---AQSLNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGT---RKVFMLAVTLFT 87
Cdd:cd17319 182 WGLALGYFGINYALYGLLTWLPTYlkqARGFSLKQVGLLAAIPFLAGAIGMI--LGGRLSDRLLRgarRLVIIIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 88 LGSLACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTW-ASWHW 166
Cdd:cd17319 260 VGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTA 339
|
170
....*....|....
gi 489959096 167 IFLINIPIGVAGLI 180
Cdd:cd17319 340 AFLFLAAVALLAAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
289-451 |
6.08e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.68 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 289 LQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVgvtIFIGLMIAQFSLQSAALPIWMLILPLFVLGMAM 368
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL---LGLLLMALGLLLFALAPSYPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 369 STQFTSMNTItLADLTDENASSGNSVLavtqQLSISLGVAVSAAVLRFYEGFDGTNTVeqfHYTFITMGALTVVSAVVFM 448
Cdd:COG0738 111 GLLDVAANPY-VAALGPETAASRLNLL----HAFFSLGALLGPLLGGLLILLGLSLSW---HLPYLILAVLLLLLALLFL 182
|
...
gi 489959096 449 LLK 451
Cdd:COG0738 183 RSK 185
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-152 |
7.11e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 13 PWIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLA 92
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489959096 93 CALSTSLTELVIFR---VLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGP 152
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-385 |
7.22e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 21 FMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLT 100
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 101 ELVIFRVLQGIGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVlvtwaswhwiflinipigvagli 180
Cdd:cd17477 86 VWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL----------------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 181 yarkympnfttprrsFDMGGFFLFGLSlvlfssgmelfgekivatwlALAVILSGILLFLLYIRHARRHPTPLISLSLFn 260
Cdd:cd17477 143 ---------------VGTAGALPFLIA--------------------AVLLLLALVPLLLTRRAAPEIEEAESISLRRL- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 261 TRTFSVGIAGNIASRLGTGCVPFLMPLMLqVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTifIGL 340
Cdd:cd17477 187 LRIAPLALLGAFVAGFLEGAFYSLLPLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA--LLG 263
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489959096 341 MIAQFSLQSAALPIWMLILPLFVLGMAMSTqftsMNTITLADLTD 385
Cdd:cd17477 264 ALAALLLPLVPGLPLALLVLLFLWGGAAGP----LYTLALALAGD 304
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
65-113 |
7.40e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.49 E-value: 7.40e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 489959096 65 VSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGG 113
Cdd:cd17379 52 VIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFG 100
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
57-114 |
7.78e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.84 E-value: 7.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 57 LTVAMLI--PVSGWLADRFGTRKVFMLAVTLFTLGSLACALSTSLTELVIFRVLQGIGGA 114
Cdd:TIGR00898 136 FFVGVLLgsFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIG 195
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-184 |
8.62e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.30 E-value: 8.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 14 WIAAMAFFMQALDATILNTALPAIAQSLNRSPLAMQSAIISYTLtVAMLI--PVSGWLADRFGTRKVFMLAVTLFTLGSL 91
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW-GGMTIgrFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 92 ACALSTSLTELVIFRVLQGIGGAMMMPVARLALLRAYPRSeLLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLIN 171
Cdd:COG0738 292 LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370
|
170
....*....|...
gi 489959096 172 IPIGVAGLIYARK 184
Cdd:COG0738 371 LVCYLLILLLALA 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
270-467 |
9.84e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 270 GNIASRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTAMGSILAKSTVTQVLRWFGYRKTLVGVTIFIGLMIAQFSLQS 349
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959096 350 aalPIWMLILPLFVLGMAMSTQFTSMNTITLADLTDENASSGNSVLAVTQQLSISLGVAVSAAVLRFYEgfdgtntveqF 429
Cdd:pfam07690 84 ---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----------W 150
|
170 180 190
....*....|....*....|....*....|....*...
gi 489959096 430 HYTFITMGALTVVSAVVFMLLKPKDGRNLIKERHKEKA 467
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188
|
|
| |
