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Conserved domains on  [gi|489959770|ref|WP_003863077|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Enterobacter]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4002925

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-144 4.30e-51

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 159.66  E-value: 4.30e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959770  12 PALTNALSALSMEV-AKTSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRESPLFSAREKAALA 90
Cdd:COG2128    3 PELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAALA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489959770  91 FTEALTQIGvHGVSDALYRSVAEHFSDVEISELNFAIVAINAWNRLGITSRMEP 144
Cdd:COG2128   83 FAEALTRTP-GGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPP 135
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-144 4.30e-51

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 159.66  E-value: 4.30e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959770  12 PALTNALSALSMEV-AKTSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRESPLFSAREKAALA 90
Cdd:COG2128    3 PELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAALA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489959770  91 FTEALTQIGvHGVSDALYRSVAEHFSDVEISELNFAIVAINAWNRLGITSRMEP 144
Cdd:COG2128   83 FAEALTRTP-GGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPP 135
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 12-94 3.80e-16

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 68.88  E-value: 3.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959770   12 PALTNALSALSM-EVAKTSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRESPLFSAREKAALA 90
Cdd:pfam02627   1 PELLAALTALAFgLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 489959770   91 FTEA 94
Cdd:pfam02627  81 AAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 28-77 1.10e-11

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 56.61  E-value: 1.10e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489959770   28 TSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRE 77
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 12-144 4.30e-51

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 159.66  E-value: 4.30e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959770  12 PALTNALSALSMEV-AKTSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRESPLFSAREKAALA 90
Cdd:COG2128    3 PELLKAFLALSGALmAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAALA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489959770  91 FTEALTQIGvHGVSDALYRSVAEHFSDVEISELNFAIVAINAWNRLGITSRMEP 144
Cdd:COG2128   83 FAEALTRTP-GGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPP 135
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 12-94 3.80e-16

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 68.88  E-value: 3.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959770   12 PALTNALSALSM-EVAKTSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRESPLFSAREKAALA 90
Cdd:pfam02627   1 PELLAALTALAFgLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 489959770   91 FTEA 94
Cdd:pfam02627  81 AAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 28-77 1.10e-11

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 56.61  E-value: 1.10e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489959770   28 TSIDPALKHLIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRE 77
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 37-144 2.50e-05

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 42.40  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959770   37 LIDIRVSQLNGCTFCLDMHSKEAKIAGERELRLYHLAAWRESPLFSAREKAALAFTEALTQIGVHGVSDALYRSVAEHFS 116
Cdd:TIGR01926  67 LIAVVVSRANGCVYCAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFAVKLTATPAKVNEADFAALRAAGFS 146

                          90       100
                  ....*....|....*....|....*....
gi 489959770  117 DVEISELnFAIVAINAW-NRLGITSRMEP 144
Cdd:TIGR01926 147 DLDILDL-IHSVAFFNWaNRLMLALGEPP 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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