|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-376 |
5.31e-84 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 260.56 E-value: 5.31e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL 84
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 85 AWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVS 164
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 165 LLGVIALVASLLLVPSSIPGRASAS--LSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLglLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAvPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAery 322
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGR-RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA--- 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489959941 323 tPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17324 317 -PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
3-381 |
4.48e-65 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 212.06 E-value: 4.48e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:PRK03545 9 LRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:PRK03545 89 VLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVASLLLVPsSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:PRK03545 169 IGGGALITLLLLIKLLP-LLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASI-QYAALVTVLVMGIFAFGnvPGLQVYVVQKAer 321
Cdd:PRK03545 248 LLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEwHLSVLSIFWGIAIMCIG--LAMQVKVLKLA-- 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 322 ytPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGLSGR 381
Cdd:PRK03545 324 --PDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSILIFR 381
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
1-384 |
4.58e-64 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 209.56 E-value: 4.58e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 1 MPLALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTA 80
Cdd:PRK10091 1 MKKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 81 GNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETF 160
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 161 LAVSLLGVIALVASLLLVPsSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSW 240
Cdd:PRK10091 161 LLIAVFNIAVLASIYFWVP-DIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 241 ILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAE 320
Cdd:PRK10091 240 IMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFICCAGLFALSAPLQILLLQNAK 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 321 rytPNAVDVASGLNIaAFNIGIALGSVIGGQTVEH-VGLTQTPWIGAVIVLVAFLLIGLSGRLDK 384
Cdd:PRK10091 320 ---GGELLGAAGGQI-AFNLGSAIGAYCGGMMLTLgLAYNYVALPAALLSFAAMSSLLLYGRYKR 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-344 |
7.22e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 7.22e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVASLLLVPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIqYAALVTVLVMGIFAFGNVPGLQVYVvqkAERY 322
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFPLLQALV---AELA 325
|
330 340
....*....|....*....|..
gi 489959941 323 TPNAVDVASGLNIAAFNIGIAL 344
Cdd:COG2814 326 PPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-376 |
5.32e-33 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 126.92 E-value: 5.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLG 167
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 168 VIALVASLLLVPSSIPGRASASLSDQVK------VLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWI 241
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLrsglrlLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 242 LLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIqYAALVTVLVMGIFAFGNVPGLQVYVvqkAER 321
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF-WLLLLLLALLGLGLGLVFPATLALL---ADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 322 YTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-389 |
5.34e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.22 E-value: 5.34e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 6 LALTISAFAIGTTEFVIVG-LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL 84
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 85 AWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVS 164
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 165 LLGVIALVASLLLV---PSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWI 241
Cdd:COG2223 167 ILLLVVAVLAWLFLrdpPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 242 LLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvqkAER 321
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV---PDI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489959941 322 YTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTP-WIGAVIVLVAFLLIGLSGRLDKPARVA 389
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
4-376 |
3.72e-27 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 111.16 E-value: 3.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 4 ALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNI 83
Cdd:PRK10213 21 AVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 84 LAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAV 163
Cdd:PRK10213 101 LVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 164 SLLGVIALVASLLLVPsSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILL 243
Cdd:PRK10213 181 AVMGVLCIFWIIKSLP-SLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 244 GYGISVAIGNIWGGKLAdKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGiFAFGNVP-GLQVYVVqkaeRY 322
Cdd:PRK10213 260 SFGIASFVGTSLSSFIL-KRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWG-LTFALVPvGWSTWIT----RS 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489959941 323 TPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:PRK10213 334 LADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLV 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-381 |
1.26e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.19 E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVAslllvpssipgrasaslsdqvkvlthpRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:COG2271 170 LGLPGLLLALL---------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAVPALKFIFAALV-VLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvqkAER 321
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLaALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALA---AEL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 322 YTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGLSGR 381
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-376 |
2.56e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 105.73 E-value: 2.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQhFGWRETFLAVSLLGVIALVASLLLVPSSIPGRA 186
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 187 SAS---LSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKH 263
Cdd:cd17474 182 SSSatkLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 264 -GAVPALKFIFAALVVLLMIFQFTASiQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVdvaSGLNIAAFNIGI 342
Cdd:cd17474 262 fGARRILVIGLLLYALSLLLLGFVPS-LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTA---SSLYNFVRFLGQ 337
|
330 340 350
....*....|....*....|....*....|....
gi 489959941 343 ALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17474 338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-350 |
6.74e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 104.58 E-value: 6.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVfFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLG 167
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 168 VIALVASLLLVpssipgrasaslsdqVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQE----LAGFSPGAVSWILL 243
Cdd:cd17504 160 VLLAALVPLID---------------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 244 GYGISVAIGNIWGGKLADKHGAVPALKF--IFAALVVLLMIFQFTASIQYAALVTVLVMGI-FAFGNVPGLQVYVVQKAE 320
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPRRVLLIglVISAVGLLLLALLHSSLWALVVALLLIGIGLgLAFASLPNIVVESVPPDR 304
|
330 340 350
....*....|....*....|....*....|
gi 489959941 321 RytpnavDVASGLNIAAFNIGIALGSVIGG 350
Cdd:cd17504 305 T------GIATGMNTVLRTIGSAIGPAIAG 328
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
27-307 |
5.14e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 101.88 E-value: 5.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSSIPG-- 184
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEek 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 185 ---RASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLAD 261
Cdd:cd17320 183 rkpLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVR 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489959941 262 KHGAVPALKFIFAALVV-LLMIFQFTASIQYAALVTVLVMGIFAFGN 307
Cdd:cd17320 263 RFGPRRLLRLGLLLLLAaALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-346 |
1.88e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.80 E-value: 1.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLG 167
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 168 VIALVASLLLVPSSIPGRASASLSDQVKVLTHPRLL-----LIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALlrdpvLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAVPALKF--IFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvqkAE 320
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLalLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV---SD 318
|
330 340
....*....|....*....|....*.
gi 489959941 321 RYTPNAVDVASGLNIAAFNIGIALGS 346
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
8-375 |
6.21e-23 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 98.82 E-value: 6.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLG 167
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 168 VIALVASLLL-VPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAvswILLGYG 246
Cdd:cd17489 161 LLALLLVFLVkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL---FFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 247 ISVAIGNIWGGKLADKHG----AVPALKFIFAALVVLLMIFQFTasiqyAALVTVLVMGIfAFGNV-PGLQVYVVQKAEr 321
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGpktvIIPGLLLLALGLLLLSFAGSPW-----MLLLAAVLYGL-GFGLLfPALQALAVDLVP- 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489959941 322 ytPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLL 375
Cdd:cd17489 311 --PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-350 |
3.72e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 93.78 E-value: 3.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:cd17321 20 PTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASlllvpssipgra 186
Cdd:cd17321 100 AIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 187 saslsdqvkvlthPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAV 266
Cdd:cd17321 168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 267 P--ALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAErytPNAVDVASGLNIAAFNIGIAL 344
Cdd:cd17321 235 LvlVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVP---KEKAGAASGILNTARQLGGAL 311
|
....*.
gi 489959941 345 GSVIGG 350
Cdd:cd17321 312 GVALLG 317
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
26-374 |
7.94e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 89.94 E-value: 7.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 26 VPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAH 105
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 106 GVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLvpssipgr 185
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL-------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 186 asaslsdQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGA 265
Cdd:cd17503 171 -------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 266 VPALKFIFAALVV-LLMIFQFTASIQYAALVTVL-VMGI-FAFGNVPGLQVYVVQKAERYTPNAVDVASGLNIAAFNIGI 342
Cdd:cd17503 244 RLLLLAGLLLLALgTLLLAFLTPDTSLWLIILPLfIRGLgMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGT 323
|
330 340 350
....*....|....*....|....*....|..
gi 489959941 343 ALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFL 374
Cdd:cd17503 324 ALLATLLTNRTQFHHSRLSELLAQQVQKQALI 355
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-376 |
9.59e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 9.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQH--FGWRETFLAVSL 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 166 LGVIALVASLLLVPS--------SIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGA 237
Cdd:cd06174 161 LALLAAILLLLVVPDppesarakNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 238 VSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvq 317
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI-- 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489959941 318 kAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd06174 319 -AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-383 |
1.15e-19 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 89.18 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLA 104
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFlavsLLGVIALVASLLLVPSSipg 184
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----LLGGVPPLILLPLLRGT--- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 185 rasaslsdqvkvlthprlLLIYAVTALGYGGVFTAFTFLAPMMQElAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHG 264
Cdd:cd17365 174 ------------------LLLWVTFFMGLLLVYLLNSWLPKLMVE-AGYSLSQALTITLLLNIGGVIGSLLLGWLADRFG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 265 AVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvqkAERYTPNAVDVASGLNIAAFNIGIAL 344
Cdd:cd17365 235 PKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALA---ARFYPTEVRATGVGWALGVGRLGAIL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489959941 345 GSVIGGQTVE-HVGLTQTPWIGAVIVLVAFLLIGLSGRLD 383
Cdd:cd17365 312 GPLLGGLLLAaGLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-378 |
4.25e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.01 E-value: 4.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKeKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVASLLLVPSSIPGRASASLSDQVK-VLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQElAGFSPGAVSWI 241
Cdd:COG2807 177 WALLALLALLLWLPLLRRRPAAAAAAPAAASLRsLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 242 LLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFqFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAEr 321
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLG-LLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR- 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489959941 322 yTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:COG2807 334 -TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
41-181 |
1.61e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 81.16 E-value: 1.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLV 120
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959941 121 PKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS 181
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-378 |
2.31e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 85.31 E-value: 2.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSsipgra 186
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 187 saslsdqvkvlthprlLLIYAVTALGYGGVFTAF-TFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGA 265
Cdd:cd17319 181 ----------------VWGLALGYFGINYALYGLlTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 266 VPALKFIFAALVVLLMIFQFTASIQyAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVDVASGLNIAAFNIGIALG 345
Cdd:cd17319 245 GARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA 323
|
330 340 350
....*....|....*....|....*....|...
gi 489959941 346 SVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17319 324 PLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-378 |
1.21e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.39 E-value: 1.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 40 AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSL 119
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 120 VPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQhFGWRETFLaVSLLGVIALVASLLLVPSSIP--GRASASLSDQVKVL 197
Cdd:cd17473 117 FEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFL-VYLLALPVLILVLLFLPEPARksKSAASPGAATAAAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 198 THPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADK--HGAVPALKFIFAA 275
Cdd:cd17473 195 PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRlgKRRLLAIGFALMA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 276 LVVLLMifqFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAeryTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEH 355
Cdd:cd17473 275 LGFLLL---ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV---PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|...
gi 489959941 356 VGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
3-376 |
1.36e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 83.44 E-value: 1.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTtefvivgLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:cd17475 3 LAQAAASLVAQGIPA-------LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:cd17475 76 LLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVASLLL-----VPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGA 237
Cdd:cd17475 156 AGLVSILAAVLFWLFyreppAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 238 VSWILLGYGISVAIGNIWGGKLADKHGA---VPALKFIFAALVVLLMIFQF-TASIQYAALVTVL-VMGIFAFGNVPglq 312
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLlSPGTPLWLLVLLLiLLGLFAIGWNG--- 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 313 VYVVQKAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIG-AVIVLVAFLLI 376
Cdd:cd17475 313 LYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLAlALLLVLAALLL 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-386 |
2.10e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.98 E-value: 2.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPkEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVASLLLVPSSIPG------RASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPG 236
Cdd:COG0738 167 YLILAVLLLLLALLFLRSKLPEieeeeeEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 237 AVSWILLGYGISVAIGNIWGGKLADKHGAVPALkFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVV 316
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 317 QKAERYTPNAVdvaSGLNIAAFnIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGLSGRLDKPA 386
Cdd:COG0738 326 DGLGKRTAAAV---SAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
21-375 |
1.42e-16 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 79.91 E-value: 1.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 21 VIVGLVPTIAEQLAiSLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLL 100
Cdd:cd17502 14 IVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 101 TGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVasllLVPS 180
Cdd:cd17502 93 QGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALA----LLRT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 181 SipgrasaslsdqvkvlthprlLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLA 260
Cdd:cd17502 169 I---------------------LLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 261 DKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVDVAsglnIAAFNI 340
Cdd:cd17502 228 SKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVA----TATNTF 303
|
330 340 350
....*....|....*....|....*....|....*
gi 489959941 341 GIALGSVIGgqtvehVGLTQTPWIGAVIVLVAFLL 375
Cdd:cd17502 304 FRSLGGTLG------VAITDVFLVALALAALAFLL 332
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
27-350 |
2.20e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 77.01 E-value: 2.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSSI---- 182
Cdd:TIGR00895 121 GLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIdflv 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 183 ----------------------------PGRASASLSDQVKVLTHPRL----LLIYAVTALGYGGVFTAFTFLAPMMQEl 230
Cdd:TIGR00895 201 skrpetvrrivnaiapqmqaeaqsalpeQKSTQGTKRSVFKALFQGKTaritVLLWLLYFMLLVGVYFLTNWLPKLMVE- 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 231 AGFSPGAVSWILLGYGISVAIGNIWGGKLADKHG-AVPALKFIFAALVVLLMIFQFTASIqyAALVTVLVMGIFAFGNVP 309
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGpRVTALLLLLGAVFAVLVGSTLFSPT--LLLLLGAIAGFFVNGGQS 357
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 489959941 310 GLQVYVvqkAERYTPNAVDVASGLNIAAFNIGIALGSVIGG 350
Cdd:TIGR00895 358 GLYALM---ALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-378 |
2.44e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 76.49 E-value: 2.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTIAE--QLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFG----GLTVALVTGVPLGTFIGQHFGWRE 158
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 159 TFLAVSLLGVIALVAslllvpssipgrasaslsdqvkvltHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAV 238
Cdd:cd17316 161 LFLIGALPALLALLL-------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 239 SWILLGYGISVAIGNIWGGKLADKHGAVPALkFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQk 318
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGRKKTL-VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYL- 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 319 AERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17316 294 AELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-283 |
9.91e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.08 E-value: 9.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 163 VSLLGVIALVASLLLVPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIF 283
Cdd:COG0477 254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
26-375 |
1.39e-14 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 74.56 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 26 VPTI---AEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFT-AGNILAWQAPDYTTLVIARLLT 101
Cdd:cd17490 16 VPFLspyAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 102 GLAHGVFFSIGSTIAtSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLV-PS 180
Cdd:cd17490 96 GIAAATWVSFTVLYA-SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKeER 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 181 SIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVF-TAFTFLAPMMQELaGFSPGAVSWILLGYGISVAIGNIWGG-K 258
Cdd:cd17490 175 REKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFsTTFGFTPLIAKQL-GASSFQLGLLSIIYLLPNALASLLSGtL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 259 LADKHGAVPALKFIFAALVVLLMIFQFTASIqYAALVTVLVMGI---FAFGNVPGLQVYVVQKAERYTpnavdvASGLNI 335
Cdd:cd17490 254 FYKKLGERNTIIIGFLLLGAYCFLIPFAPNL-TLLYLLQALNGFgtgILFPLLMSLSIEGVPAEQRST------AMGFFQ 326
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489959941 336 AAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLL 375
Cdd:cd17490 327 AIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
21-262 |
8.07e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 72.22 E-value: 8.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 21 VIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLL 100
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 101 TGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPS 180
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 181 SIpgrasaslsdqvkvlthprLLLIYavTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLA 260
Cdd:cd17323 177 VL-------------------LLGLY--VGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLS 235
|
..
gi 489959941 261 DK 262
Cdd:cd17323 236 DY 237
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
24-376 |
1.39e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 71.53 E-value: 1.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 24 GLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGL 103
Cdd:cd17355 24 VFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 104 AHGVFFSIGST-IATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLL----- 177
Cdd:cd17355 104 GGAGTLAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLlrrrp 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 178 -----VPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMmqELAGFSPGAVSWILLGYGISVAIG 252
Cdd:cd17355 184 adlalRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL--ADRGISPAAAAVALALIGLFNIVG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 253 NIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvqkAERYTPNAVDVASG 332
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALA---ARYFGARSYGTLFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489959941 333 LNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALL 382
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
53-308 |
7.61e-13 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 69.25 E-value: 7.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 53 VGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTT--------LVIARLLTGLAHGVFFSIGSTIATSLVPKEK 124
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 125 ---AASAIAI-MFGGLTVALVTGVPLGTFIGQH----FGWRETFLAVSLLGVIALVASLLLVPS----SIPGRASASLSD 192
Cdd:cd17367 135 rgfYSSFQYVtLIGGQLLALGVLLVLQHTLGEDqmaaWGWRIPFLLGGVLAVVVLWLRRGLEETesfeAIAESNEASAGT 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 193 QVKVLTHPR-LLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKF 271
Cdd:cd17367 215 LRELRRHPReLLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLF 294
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 489959941 272 IFAALVVLLMIFQFTASIQ---YAALVTVLVMGIFAFGNV 308
Cdd:cd17367 295 FGIGGTLATVPLLSALDHTdspYTAFALVLVGLVFLSGYT 334
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-376 |
8.62e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 68.74 E-value: 8.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 21 VIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLL 100
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 101 TGLAHGVFFSIGSTIAtSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPS 180
Cdd:cd17478 94 AGIGSAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 181 S--IPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGK 258
Cdd:cd17478 173 KkpEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 259 LADKHGAVPALKFIFAALVVLLMIFQFTASIqyAALVTVLVMGIFAFGNVPGLQVYvvqkAERYTPNAVDVASGLNIAAF 338
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGI--WSYILLVLAGFLLFASFPVTVVL----AQELLPGNVGLASGLMMGLS 326
|
330 340 350
....*....|....*....|....*....|....*...
gi 489959941 339 NIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17478 327 FGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
10-375 |
3.54e-12 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 66.94 E-value: 3.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 10 ISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAP 89
Cdd:cd06180 6 ALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 90 DYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVA-LVTGVPLGTFIGQHFGWRETFLAVSLLGV 168
Cdd:cd06180 86 GFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGiALSGLLVPAGLGGGLSWRAGWLALALLSA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 169 IALVASLLLVPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAfTFLAPMMQELAGFSPGAVSWILLGyGIS 248
Cdd:cd06180 166 VLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITA-TFLPLIARETGAGSLLAGLLWSLF-GLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 249 VAIGNIWGGKLADKHGAVPALkfifaALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVD 328
Cdd:cd06180 244 AVPSCFLWGALSDRWGTRRAL-----AANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAP 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489959941 329 VASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTP-WIGAVIVLVAFLL 375
Cdd:cd06180 319 RALALMTASFGVGQILGPLLAGWLADATGGFAPAlILAAAALVVAALL 366
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
8-376 |
4.49e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 66.81 E-value: 4.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGvPLGTFIGQHFGWReTFLAVSLLG 167
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGAL-PFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 168 VIALVAsLLLVPSSIPGRASASLSDQVKVLTHPRLLLiyaVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGI 247
Cdd:cd17477 159 LLALVP-LLLTRRAAPEIEEAESISLRRLLRIAPLAL---LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 248 SVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPglqVYVVQKAERYTPNAV 327
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT---LALALAGDRLPGDEL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489959941 328 DVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
10-375 |
9.12e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 65.81 E-value: 9.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 10 ISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAP 89
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 90 DYTTLVIARLLTGLAHGVFFSIGSTIATSLVPkEKAASAIAIMFGGLTVALVTGVPLGTFIG-QHFGWRETFLAVSLLGV 168
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 169 IALVASLL-----LVPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAF-TFLAPMMQELAGFSPGAVSWIL 242
Cdd:cd17333 162 LLAILILLtlfpeLPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFsSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADKHGAvPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERY 322
Cdd:cd17333 242 SGFWVGITIGRLLGGPISRRIKP-HTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489959941 323 TPNAVDVAsglnIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLL 375
Cdd:cd17333 321 KGKGTSVL----LAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
40-377 |
1.22e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 65.36 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 40 AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGvFFSIGSTIATSL 119
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 120 VPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVP---SSIPGRASASLSDQVKV 196
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKedfKPVEKKKMVSTKEVWNS 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 197 LTHPRLLL-IYAVTALGYGGVFTAFTFLAPMMQELAGFSPGA--VSWILLGY-GISVAIGNIWGGKLADKHGAvPALKFI 272
Cdd:cd17391 197 VPNPSLLIsLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLafISGLVFSAtGVSSLLSAPRLGKLGDRIGH-HRILLG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 273 FAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVqkaeRYTPNAV-DVASGLNIAAFNIGIALGSVIGGQ 351
Cdd:cd17391 276 ALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA----KITPKEVaGRIFGYNQSFQYLGNVAGPLLGSA 351
|
330 340
....*....|....*....|....*.
gi 489959941 352 TVEHVGltqtpwIGAVIVLVAFLLIG 377
Cdd:cd17391 352 IAAHFG------YRAVFVVTALLVLL 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
40-378 |
2.15e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 64.54 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 40 AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLahGVFFSIGSTIATSL 119
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 120 VPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS--IPGRASASLSDQVKVL 197
Cdd:cd17472 112 TREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPpkIVQISEKEKKKLKKLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 198 THPRLLLIYAVTALGYGGVFTAFTFLaPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAvpaLKFIFAALV 277
Cdd:cd17472 192 KNKRLLRLDFSIFILHFVLMAFFYIL-PLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGK---MKQVFVSSI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 278 VLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAvdvASGLNIAAFN----IGIALGSVIGGQTV 353
Cdd:cd17472 268 LLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKE---YRGTAMGIYNtsqfLGSFLGGALGGLLW 344
|
330 340
....*....|....*....|....*
gi 489959941 354 EHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17472 345 GLLGYSSVFLTILILALLWLLVSFL 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
29-375 |
2.28e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 2.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 29 IAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVF 108
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 109 FSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQhFGWRETFLAVSLLGVIALVASLLLVPSSIPGRASA 188
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 189 SLSDQVK----VLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKhg 264
Cdd:cd17329 185 EKTEILRgykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVER-- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 265 avPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFG---NVPGLQVYVVQKAErytPNAVDVASGLNIAAFNIG 341
Cdd:cd17329 263 --FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAP---PDKRGSYMGFYALAWGLG 337
|
330 340 350
....*....|....*....|....*....|....
gi 489959941 342 IALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLL 375
Cdd:cd17329 338 RAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-375 |
3.87e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.15 E-value: 3.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTI-AEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFA-----RKKLLVALMVLF 78
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 79 TAGNILAWQAPD--YTTLVIARLLTGLAHGVFFSIGSTIATSLVP--------KEKAASAIAIM-FGGLTVALVTGVPLG 147
Cdd:COG2211 92 ALSFVLLFTAPDlsPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdyeeRTRLSSWRFAFaGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 148 TFIG--QHFGWRETFLAVSLLGVIALVASLLLVPSSI-PGRASASLSDQVKVLTHPR-LLLIYAVTALGYGGVFTAFTFL 223
Cdd:COG2211 172 AAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKERPvPEEEKVSLKESLKALLKNRpFLLLLLAYLLFFLALALVAALL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 224 APMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIF 303
Cdd:COG2211 252 LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 304 AFG----NVPGLQVYVVQKAERYTPNAVD-VASGLNIAAFNIGIALGSVIGGQTVEHVG----LTQTPWIGAVIVLVAFL 374
Cdd:COG2211 332 GLGailvLPWAMLADVVDYDEWKTGRRREgLYFGIFTFAIKLGQALAGALAGLLLALFGyvagAAQSPSALTGIRLLFFL 411
|
.
gi 489959941 375 L 375
Cdd:COG2211 412 L 412
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
27-306 |
9.01e-11 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 63.06 E-value: 9.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSSIPGRA 186
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 187 SASLSDQ----VKVLTHPRLLLIYAVTALGYGGVFTAFTFLA---PMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKL 259
Cdd:PRK11551 199 AAGAGKQrapvLRALFGEGRATATLLLWISYFFTLIVLYFLLnwlPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGAL 278
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489959941 260 ADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVtVLVMGIFAFG 306
Cdd:PRK11551 279 MDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLA-GFAAGLFVVG 324
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
4-378 |
3.48e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 4 ALLALTISAFAIGTTeFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNI 83
Cdd:cd17330 1 LFLVVFLDALGFGIV-FPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 84 LAWQAPDYTTLVIARLLTGLAHGVfFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAV 163
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 164 SLLGVIALVASLLLVPSSipgrasaslsdqvkvlthPRLLLIYAVTALGYGGVFTAFTFLAPmmqELAGFSPGAVSWILL 243
Cdd:cd17330 159 AALALLNLVLVLFFLPPL------------------RRLLLVYFLIALAFAGLESVFSLFLK---DRFGFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 244 GYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVvqkAERYT 323
Cdd:cd17330 218 LVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALL---SKSVP 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 324 PNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17330 295 SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
40-376 |
5.00e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.71 E-value: 5.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 40 AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL-----AWQAPDYTTLVIARLLTGLAHGVFFSIGST 114
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVlallaLLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 115 IATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLL-------VPSSIPGRAS 187
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIrrpppaaPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 188 ASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVP 267
Cdd:cd06173 196 DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 268 ALKFIFAALVVLLMIFQFTASIqYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVdvaSGLNIAAFNIGIALGSV 347
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSL-WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV---FSVYNALNSGAMPLGAL 351
|
330 340
....*....|....*....|....*....
gi 489959941 348 IGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd06173 352 LAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-179 |
6.54e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 6.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 1 MPLALLALTISAFAIGTTEFVIVGLVPTI-AEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFAR--KKLLVALMVL 77
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 78 FTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWR 157
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|..
gi 489959941 158 ETFLAVSLLGVIALVASLLLVP 179
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLR 359
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-328 |
7.63e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 59.94 E-value: 7.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 19 EFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIAR 98
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 99 LLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHF-GWRETFLAVSLLGVIALVASLLL 177
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 178 VPSSIPGRA----------SASLSDQVKVLTHPRLLLI----YAVTALGYGGVFTAFTFLApMMQELAGFSPGAVSWILL 243
Cdd:cd17328 175 VREPPRGAAeggvmakstaTSFLADLKALAKNPSFILStlgfTAVSFVTGALAFWAPTFFL-RAFGVGDLSSADVGLIFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 244 GY-GISVAIGNIWGGKLADKHGA--------VPALKFIFAALVVLLMIFQFTASIqYAALVTVLVMGIFAFGN---VPGL 311
Cdd:cd17328 254 AItCIAGVLGVLLGGILADRLRRktpradplVCAVGLLAAAPFLFLALVLALSNL-LLAWVLLFLGEFLLSLNwapVFAI 332
|
330
....*....|....*..
gi 489959941 312 QVYVVQKAERYTPNAVD 328
Cdd:cd17328 333 LLYVVIPTRRSTASAIQ 349
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
25-378 |
2.94e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.03 E-value: 2.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQA-PDYTTLVIARLLTGL 103
Cdd:cd17341 21 LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLLGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 104 AHGVfFSIGSTIATSLVPKEKAASAIAIMFG----GLTVALVTGVPL---GTFIGQHFGWRETFLAVSLLGVIALVASLL 176
Cdd:cd17341 101 AGAN-FASGQPWASFWFPKEKIGGAAGGIAGagnmGVAVSQLLAPLIagaIVFDGGFVGWRNAFFVPGILLAIAAVLVLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 177 LVPSSIPGRASA--SLSDQVKVLTHPR---LLLIYAVTAlgygGVFTAFTFLAPM-MQELAGFSPGAVSWILLGYGISVA 250
Cdd:cd17341 180 FGDDLPTGKASAleFLKVQLAVLKNYRtwiLSLLYGVTF----GSFVGFSNVLPTyFKTRFGLPLVTAGILAALFPLAGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 251 IGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVDVA 330
Cdd:cd17341 256 LARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRRELGAV 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489959941 331 SGLNIAAFNIGIALGSVIGGQTVEHVGLTQT-PWIGAVIVLVAFLLIGL 378
Cdd:cd17341 336 TGLVGAIGGLGGFFLPLLFGSSALMTGSGVGaFSLFGVLAVACTLLVWL 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
25-376 |
3.88e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 58.01 E-value: 3.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLViarlltgLA 104
Cdd:cd17353 25 FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF-------LG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVFFSIGS----TIATSLVPK---EKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLL-GVIALVASLL 176
Cdd:cd17353 98 YGVLGGIGAgigyITPVSTAVKwfpDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIfLIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 177 L-------VPSSIPGRASASLSDQVKV-----LTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLG 244
Cdd:cd17353 178 IrdppkgwVPPGVDPLANNAENSPRDYtpremLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 245 YGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIqyaALVTVLVMGIFAFGNVPGLQVYVVQKAERYTP 324
Cdd:cd17353 258 LSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSV---AVLFVLGVALIGFCYGGGFALFPALTADFFGT 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489959941 325 NAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17353 335 KNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALA 386
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-178 |
5.93e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.22 E-value: 5.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 9 TISAFAIGTTEFVIVGLVPTIAEQLAISlpSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQA 88
Cdd:cd17489 200 ALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 89 PDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGV 168
Cdd:cd17489 278 GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
170
....*....|
gi 489959941 169 IALVASLLLV 178
Cdd:cd17489 358 LALVLYIFLL 367
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-378 |
8.29e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.93 E-value: 8.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLA 104
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFI----GQHFGWRETFLAVSLLGVIALVASLLLVPS 180
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfpllPPEIAWRVLFLLGALPALLVLFIRRFVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 181 SIPGRASASLS-----DQVKVLTHPRLLLIYAVTAL----GYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAI 251
Cdd:cd17371 181 PQWQAARAARRhfadrPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 252 GNIWGGKLADKHGAVPALKFIFA-ALVVLLMIFQFTASIQyAALVTVLVMGIFAFGNVPGLQVYVvqkAERYTPNAVDVA 330
Cdd:cd17371 261 GYLAGGFLADRIGRRNNFALFALgSAISILLYFFLPLSPT-LILILGFPLGFFASGPFSGMGAYL---TELFPTAVRATA 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489959941 331 SGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17371 337 QGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLAL 384
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
2-180 |
1.82e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 56.18 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 2 PLALLALTISAFAIGTT--EFVIVGLVPTIAEQLAISLPSA---GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMV 76
Cdd:TIGR00898 86 PLKLSDLGLAATEPCLDgwEYSYDTFSSTIVTEWDLVCEDAwkvDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 77 LFTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQhfgW 156
Cdd:TIGR00898 166 VTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---W 242
|
170 180
....*....|....*....|....
gi 489959941 157 RETFLAVSLLGVIALVASLLLVPS 180
Cdd:TIGR00898 243 RWLQLAVSLPTFLFFLLSWFVPES 266
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
64-376 |
8.92e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 53.71 E-value: 8.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 64 RFARKKLLVALMVLFTAGNIL-AWQAPDYTTLVIARLLTGLAHGVF---FSIGSTIATSlVPKEKAASAIAIMFGGLTVA 139
Cdd:cd17471 59 GGDRKPLILLALLAGALGYLLfAFLRNYWVLLLVGVVLLSLGAAAFpqlFALAREYADR-SSGRDATLFNSVLRAAFSLA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 140 LVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS-IPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFT 218
Cdd:cd17471 138 WVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVkPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSM 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 219 AFTFLAP-MMQELAgfspGAVSWILLGYGISVAIG---NIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQyaAL 294
Cdd:cd17471 218 YIIAMPLyVTNELG----GSESWVGLLFGLAAALEipiMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLW--QL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 295 VTVLVMGIFAFGNVPGLQVYVVQKaerYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFL 374
Cdd:cd17471 292 IALQLLNAIFIGITAGLGISYFQD---LMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
..
gi 489959941 375 LI 376
Cdd:cd17471 369 LL 370
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
21-376 |
1.96e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.57 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 21 VIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLL 100
Cdd:cd17359 19 VINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARII 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 101 TGLAHGVFFSIGSTIATSLVPKEKAASA-----IAIMFGGLTVALVT---GVPLGTFIGQHFGWReTFLAVSLLGVIALV 172
Cdd:cd17359 99 GGLAVGGASALVPMYIAEVAPAEIRGRLvslnqLMIVFGQLLAYIVNyliANAGGADWLGAEGWR-WMLGLEAIPAILFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 173 ASLLLVPSSipgrasaslsdqvkvlthPRLLLIYAVTALGYGGVFTAF---------TFLAPMMQELAGFSPGAVSWILL 243
Cdd:cd17359 178 LGMLFIPES------------------PRWLVSKGKPILIIGIGLAIFqqfvginviFYYGPEIFQNAGFSENAALLQTI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 244 GYGISVAIGNIWGGKLADKHGAVPALKF----IFAALVVLLMIFQFTASIQYAALVTVLVMGIF--AFGNVPGLQVYVVQ 317
Cdd:cd17359 240 GIGVVNVIFTIIAILLVDKVGRKPLLLIgsigMAISLLLIGTAFYFAPGSQASGIVALVLILLFvaFFAMSWGPVTWVLL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489959941 318 kAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:cd17359 320 -SEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLFV 377
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
2-185 |
2.49e-07 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 52.25 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 2 PLALLALTISAFAIGttefVIVGLVPTIAEQLAISLPSA----GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVL 77
Cdd:cd17388 2 IFILVTVLLDAMGIG----LIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 78 FTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIAtSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHfGWR 157
Cdd:cd17388 78 AALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIA-DVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPR 155
|
170 180
....*....|....*....|....*...
gi 489959941 158 ETFLAVSLLGVIALVASLLLVPSSIPGR 185
Cdd:cd17388 156 APFLVAAGLNGLNFLLGLFVLPESLPPE 183
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-178 |
6.06e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 6.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 7 ALTISAFAIGTTEFVIVGLVPTI----AEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLplyaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLA 162
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 489959941 163 VSLLGVIALVASLLLV 178
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
27-378 |
6.47e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.05 E-value: 6.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTA--GNILAWQAPDYTTLVIARLLTGLA 104
Cdd:cd17335 21 SVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVlfFLSLFFVAQIFWLLLLLVILGAFF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVFFSIGSTIATSLVPKEKAASAIAIMFGGL---TVALVTGvPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS 181
Cdd:cd17335 101 SAPVVPLVDSITLQYLGEERERYGKQRLWGSIgfgIAALLVG-ILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 182 IPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELaGFSPGAVSWILLGYGISVAIGNIWGGKLAD 261
Cdd:cd17335 180 KHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL-GGSKTLIGLLWTVGVVSEIPFFFFSSRLIQ 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 262 KHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAfgnvpGLQVYVVQKAERYTPNAVDVASG--LNIAAFN 339
Cdd:cd17335 259 RFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFA-----LVWAAAVSYASAAAPPGLRATAQglLQGLYFG 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 489959941 340 IGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17335 334 LGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
26-179 |
8.09e-07 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 50.89 E-value: 8.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 26 VPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAH 105
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGG 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489959941 106 GVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVP 179
Cdd:PRK10504 113 AMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMP 186
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-177 |
9.55e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 9.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 2 PLALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAG 81
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 82 NILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFL 161
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 489959941 162 AVSLLGVIALVASLLL 177
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
201-387 |
1.43e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 201 RLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLL 280
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 281 MIFQFTASIqYAALVTVLVMGIFAFGNVPGLQVYVvqkAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQ 360
Cdd:COG2814 90 LLCALAPSL-WLLLAARFLQGLGAGALFPAALALI---ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|....*..
gi 489959941 361 TPWIGAVIVLVAFLLIGLSGRLDKPAR 387
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAA 192
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
27-357 |
1.62e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHG 106
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTF-IGQHFGWRETFLAVSLLGVI-ALVASLLLVPSSI-- 182
Cdd:TIGR00881 99 MGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIvSLICFLLLRDSPQsc 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 183 --------PGRASASLSDQVK------------VLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWIL 242
Cdd:TIGR00881 179 glppaeemPNEEPDGDAEKKEeeltkkqiflqyVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 243 LGYGISVAIGNIWGGKLADK--HGAVPALKFIFAALVV--LLMIFQFTASIQYAALVTVLVMGIFAFGNVpglQVYVVQK 318
Cdd:TIGR00881 259 TLYELGGLVGTLLAGWLSDKlfNGRRGPLAVFFMALIIvsLLVYWLNPAANPLMDLICLFALGFLVYGPQ---MLIGVIA 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 489959941 319 AERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVG 357
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-182 |
1.87e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.12 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 45 SIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEK 124
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 125 --AASAIAIMFGGLTVALVTGvpLGTFIGQhfgWRETFLAVSLLGVIaLVASLLLVPSSI 182
Cdd:cd17317 112 rsFVGILFGLFWALGYMLLAL--LAYLIRD---WRWLQLAISLPGLL-FLLLLWWLPRRT 165
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
19-171 |
3.40e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 48.93 E-value: 3.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 19 EFVIVGLVPT-IAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIA 97
Cdd:PRK03893 35 DFVLITLVLTeVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIA 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489959941 98 RLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIAL 171
Cdd:PRK03893 115 RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFAL 188
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
41-301 |
3.74e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 48.61 E-value: 3.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLVA----LMVLFTAGniLAWQAPDYTTLVIARLLTGLahgVFFSIGSTIA 116
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKKPFLAfftlLGVLATAA--LFFVAPGGLWLGLLLFVLAN---IGFEGSLVFY 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 117 ----TSLVPKEK--AASAIAIMFGGLTVALVTGVPLGTFI-GQHFGWRETFLAVSLLGVIA----LVASLLLV------- 178
Cdd:COG2270 130 naflPDIATPEEigRVSGLGWALGYLGGVLLLLINLALFLkPEAFGLPDAGEAVRISFLLTalwwLLFALPLFlflperp 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 179 ------PSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGY-GGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAI 251
Cdd:COG2270 210 rpgpapPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYFFYrDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAAL 289
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489959941 252 GNIWGGKLADKHGAVPALKF-IFAALVVLLMIFQFTASIQY--AALVTVLVMG 301
Cdd:COG2270 290 GALLFGRLDDRIGPKRVILVsLVIWIVVCLAAYFLTTALAFwiLGLLIGLVMG 342
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
21-181 |
4.34e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 48.34 E-value: 4.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 21 VIVGLVPTIAEQLAISLPS--AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIAR 98
Cdd:cd17315 15 VINGALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 99 LLTGLAHGVFFSIGSTIATSLVPKEKAAsAIAIMF-----GGLTVALVTGVPLGTfigQHFGWRETFLAVSLLGVIALVA 173
Cdd:cd17315 95 FLLGLGVGLASVLVPLYISEIAPAKIRG-ALGTLNqlmitFGILLAYLLGLALSL---SPPGWWRLMFALAAVPALLQLL 170
|
....*...
gi 489959941 174 SLLLVPSS 181
Cdd:cd17315 171 LMFFLPES 178
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
25-298 |
4.46e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPdyttlvIARLLTGla 104
Cdd:cd17339 21 LLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGG------IALLFLG-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 hGVFFSIGSTIATSLVP---KEKAASAIAIMFGGLTVALVTGVPLGTFI------GQHFGWRETFLAVSLLGVIALVASL 175
Cdd:cd17339 93 -TALAGAGIAVGNVLLPsliKRDFPRRVGLMTGLYTTSMNLGAALASGLsvplaqALGGGWRGALAIWALPALLALLIWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 176 LLVPSSIPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQElAGFSPGAVSWILLGYGISVAIGNIW 255
Cdd:cd17339 172 PQLRRRKRAAAAAAPLTKISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLL 250
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489959941 256 GGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVL 298
Cdd:cd17339 251 VPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVL 293
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
3-179 |
4.67e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 48.34 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAF----AIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLF 78
Cdd:cd17358 2 LATFVANLGSFsfgiAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 79 TAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMfgglTVALVTGVPLGTFIGQHFGWRe 158
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLN----QLLVNIGILLGYVLGSFLPWR- 156
|
170 180
....*....|....*....|.
gi 489959941 159 tflAVSLLGVIALVASLLLVP 179
Cdd:cd17358 157 ---TLALIGAIPPVVFLILLF 174
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
22-251 |
4.90e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 48.09 E-value: 4.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 22 IVGLvPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLT 101
Cdd:PRK10473 23 LVGL-PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQ 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 102 GLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS 181
Cdd:PRK10473 102 GIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKET 181
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 182 IPGRASASLS---DQVKVLTHPRLLLIYAVTALGYGGVFTaFTFLAPM-MQELAGFSPGAVSWILLGY-GISVAI 251
Cdd:PRK10473 182 RPARAPAASSkprENSESLLNRFFLSRLVITTLSVTVILT-FVNTSPVlLMEQMGFSRGEYAIIMALTaGVSMTV 255
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-173 |
1.10e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 30 AEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVFF 109
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489959941 110 SIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVA 173
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
205-376 |
1.23e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.64 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 205 IYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQ 284
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 285 FTASIqYAALVTVLVMGIFAFGNVPGLQVYVvqkAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWI 364
Cdd:pfam07690 81 FASSL-WLLLVLRVLQGLGAGALFPAALALI---ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|..
gi 489959941 365 GAVIVLVAFLLI 376
Cdd:pfam07690 157 LAILSLLAAVLL 168
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
28-283 |
1.49e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 46.81 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 28 TIAEQLAISLpsagllvSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGL---A 104
Cdd:PRK11043 38 TSASAVSASL-------SLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVgvcS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVffsIGSTIATSLVPKEKAASAIA-IM-FGGLTVALVtgvP-LGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS 181
Cdd:PRK11043 111 AAV---IWQALVIDRYPAQKANRVFAtIMpLVALSPALA---PlLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 182 IPGRASASLSDQVKVLTHPRLL---LIYAVTAlgygGVFTAFTFLAPMMQELAGFSPGA---------VSWILLGYGISV 249
Cdd:PRK11043 185 KARKQSQDALTFKQLLKSKTYLgnvLIFAACS----AAFFAWLTGSPFILEQMGYSPADiglsyvpqtIAFLVGGYGCRA 260
|
250 260 270
....*....|....*....|....*....|....
gi 489959941 250 AIGNIWGGKLadkhgaVPALKFIFAALVVLLMIF 283
Cdd:PRK11043 261 ALQKWGGEQL------LPWLLVLFAVSVIAIWLA 288
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
5-375 |
1.55e-05 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 46.44 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL 84
Cdd:cd17385 1 LISLALANFSSMICYSILAPFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 85 AW---QAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASaIAIMFGGLTV----ALVTGVPLGTFIGQHFGWR 157
Cdd:cd17385 81 FGfldRVPDGTVFIALCFLVRIVEAVGFAAFITASFAIIAKEFPNN-IATVLGTLETfsglGLMLGPPLGGFLYQAGGYE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 158 ETFLAVSLLGVIALVASLLLVPSSiPGRASASLSDQVKVLTHPR-LLLIYAVTALGyggvfTAFTFLAPMMQ---ELAGF 233
Cdd:cd17385 160 LPFLVLGCLLLLTVPLNMFILPRY-DDDPSPKSGSMLKLLKIPSvLLLCLSIVSGS-----VSLGFLDPTLSphlRQFKL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 234 SPGAVSWILLGYGISVAIGNIWGGKLADKHGA---VPALKFIFAALVVLLM----IFQFTASIQYAALVTVLVMGIFAFG 306
Cdd:cd17385 234 SPGQVGLMFLILAGSYAISAPLWGWLSDKKKIpkwLMVIGSIITGVGFLLLgpapLLPIKSELWMVIIGLVLLGLSLGAA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489959941 307 NVPGLQVYVVQKAERYTPNAVD---VASGLNIAAFNIGIALGSVIGGQTVEHVGLtqtPWIGAVIVLVAFLL 375
Cdd:cd17385 314 LVPTFPELLNCAREYGFPDNLStygLVSGLFNAAFSLGAFIGPTLGGFLLERLGF---EWAATIQAGLAFVV 382
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
10-211 |
2.72e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.07 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 10 ISAFAIGTTEFVIVGLVPTIAEQLAISLPSA-----GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL 84
Cdd:PRK09874 21 LGCFLTGAAFSLVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 85 AWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSlVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVS 164
Cdd:PRK09874 101 MGLAQNIWQFLILRALLGLLGGFVPNANALIATQ-VPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITA 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 489959941 165 LLGVIALVASLLLVPSS---IPGRASASLSDQVKVLTHPRLLLIYAVTAL 211
Cdd:PRK09874 180 SVLFLCFLVTLFCIRENfqpVSKKEMLHMREVVTSLKNPKLVLSLFVTTL 229
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-139 |
3.89e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 2 PLALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAG 81
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 489959941 82 NILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVA 139
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
29-306 |
4.09e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 45.30 E-value: 4.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 29 IAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVF 108
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 109 FSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLaVSLLGVIALVASLLLVPSS------- 181
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFF-VGLLPVLLVIYIRARAPESkeweeak 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 182 IPGRASASLSDQ-------VKVLTHPRL---LLIYAVTALGYGGVFTAFTFLaPMMQELAGFSPGAVSWILLGYGISVAI 251
Cdd:PRK12307 203 LSGKGKHSQSAWsvfslsmKGLFNRAQFpltLCVFIVLFSIFGANWPIFGLL-PTYLAGEGFDTGVVSNLMTAAAFGTVL 281
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 252 GNIWGGKLADKHGavpaLKFIFAalVVLLMIFQFTASIQYAALVTVLVMGIFAFG 306
Cdd:PRK12307 282 GNIVWGLCADRIG----LKKTFS--IGLLMSFLFIFPLFRIPQDNYLLLGACLFG 330
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-177 |
5.61e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.87 E-value: 5.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTI-AEQLAISLPSAGLLVSIYALGVAVG---APVLTALTGRFARKKLLVALMVLFTA 80
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLAAIPFLAGAIGmilGGRLSDRLLRGARRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 81 GNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIM-----FGGLTVALVTGVPLGTFIGQHFG 155
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLInsggnLGGFVAPLLIGYLVDATGSYTAA 340
|
170 180
....*....|....*....|..
gi 489959941 156 wretFLAVSLLGVIALVASLLL 177
Cdd:cd17319 341 ----FLFLAAVALLAALLVLLL 358
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
26-306 |
8.69e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.19 E-value: 8.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 26 VPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAH 105
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 106 GVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLavsLLGVIALVASLLLVpssipgr 185
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFL---VPGIVGLVVAIILF------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 186 asaslsdqVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPM-MQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHG 264
Cdd:cd17312 176 --------FFLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLyLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLF 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 489959941 265 A---VPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFG 306
Cdd:cd17312 248 GgrrAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGG 292
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
3-181 |
1.06e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 44.58 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 3 LALLALTISAFAIGtteFVIvglvPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGN 82
Cdd:TIGR01299 174 LALMADGVEVFVVG---FVL----PSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFA 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGlahgvfFSIGSTIAT------SLVPKEKAASAIA-----IMFGGLTVAlvtgvPLGTFIG 151
Cdd:TIGR01299 247 FFSSFVQGYGFFLFCRLLSG------FGIGGAIPIvfsyfaEFLAQEKRGEHLSwlcmfWMIGGIYAA-----AMAWAII 315
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 489959941 152 QHFGWR------------ETFLAVSLLGVIALVASLLLVPSS 181
Cdd:TIGR01299 316 PHYGWSfqmgsayqfhswRVFVIVCAFPCVFAIGALTFMPES 357
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
38-306 |
1.11e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.05 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 38 PSAGLLVSIYALGVA-----VGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTT--------LVIARLLTGLA 104
Cdd:cd17369 39 PAAGTLAAFATFGVGflarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVFFSIGSTIATSLVPKEK---------AASAIAIMFGGLTVALVTGVPLGTFIgQHFGWRETFLAVSLLGVIALVASL 175
Cdd:cd17369 119 LGGEWGGAVLMAVEHAPPKRrgfygsfpqLGAPVGLLLATGVFLLLSALLSDEAF-LSWGWRIPFLLSAVLVAVGLYIRL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 176 LLVPSSI-----PGRASASLSDQVKVLTHPR-LLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISV 249
Cdd:cd17369 198 RLEETPVfrrakEAGQVVRAPLVEVLRRHWRaLLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVA 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 489959941 250 AIGNIWGGKLADKHGAVPAlkFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFG 306
Cdd:cd17369 278 AITIPLFGWLSDRVGRRPV--YLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLG 332
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
5-177 |
1.35e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGttEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAG--N 82
Cdd:cd17352 187 LLALGVSFAMLG--FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGlsL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 83 ILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPL-GTFIGQHFGWRETFL 161
Cdd:cd17352 265 LAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIaGLLRDYTGDYDAAFY 344
|
170
....*....|....*.
gi 489959941 162 AVSLLGVIALVASLLL 177
Cdd:cd17352 345 FCGACLLLSGVLLFLL 360
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
2-240 |
1.96e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 43.28 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 2 PLALLALTISAFAigTTEFVIVGLVPTIAE-QLAISLPSAGllVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTA 80
Cdd:PRK15403 18 PMALILYDFAAYL--TTDLIQPGIINVVRDfNADVSLAPAS--VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 81 GNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETF 160
Cdd:PRK15403 94 ACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 161 LAVSLLGVIALVASLLLVPSSI-----PGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSP 235
Cdd:PRK15403 174 AIIAVMGLIAFVGLLLAMPETVkrgavPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTT 253
|
....*
gi 489959941 236 GAVSW 240
Cdd:PRK15403 254 SQFAW 258
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
41-376 |
2.28e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.03 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTT---LVIARLLTGLAHGVFFSIGSTIAT 117
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 118 SLVPKEKAasaiAIMFGGLTVALVTGVPLGTFIGQHF-------GWReTFLAVSLLGVIALVASLLLVPSS-----IPGR 185
Cdd:pfam00083 129 EIAPKKLR----GALGSLYQLAITFGILLAYIFGLGLnktsnsdGWR-IPLGLQLVPALLLIIGLLFLPESprwlvEKGR 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 186 ---ASASLSDQVKVL-------------------------------THPRLLLIYAVTALG--YGGVFtAFTFLAPMMQE 229
Cdd:pfam00083 204 leeAREVLAKLRGVPdvdreldeikdsleagqeaekaswkelfstkTRRQRLLIGVMLQIFqqLTGIN-AIFYYSTTIFE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 230 LAGFSPGAVSWILLgyGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTA--------SIQYAALVTVLVMg 301
Cdd:pfam00083 283 NLGLSDSFLVTIIV--GVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVAllgvsksdWAGIVAIVFIALF- 359
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489959941 302 IFAFGNVPGLQVYVVQkAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLI 376
Cdd:pfam00083 360 IAFFAMGWGPVPWVIV-SELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFV 433
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
40-172 |
3.33e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.25 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 40 AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSL 119
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489959941 120 VPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALV 172
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
4-175 |
3.37e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 4 ALLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNI 83
Cdd:cd17478 196 ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 84 LAWQAPDYTTLVIArLLTGLAHGVFFSIGSTIATSLVPkEKAASAIAIMFG-GLTVALVTGVPLGtFIGQHFGWRETFLA 162
Cdd:cd17478 276 LFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGlSFGLGGIGAPVLG-ALADAFGLESVLLI 352
|
170
....*....|...
gi 489959941 163 VSLLGVIALVASL 175
Cdd:cd17478 353 LALLPLLGALLAF 365
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
11-378 |
3.50e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 42.36 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 11 SAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGApvLTALTGRFARKKLLVAL---MVLFTAGNILA-W 86
Cdd:pfam06779 1 LTVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGA--LLASFAWRHGASRLRPAllaGLLATVLLLLAmA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 87 QAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRET-FLAVSL 165
Cdd:pfam06779 79 ATSSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSlWYGAGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 166 LGVIALVASLLLVPSSIPGRASASL-SDQVKVLTHPRLLLIYAVTALGYGGVFTAfTFLaPMMQELAGFSPGAVSWILLG 244
Cdd:pfam06779 159 LSAVLTLAVFPLLPRRAPRHASAPApAAKPLQRSLPLWILTLAYGLAGFGYIITA-TFL-PAMARDGFGGPAAAALFWSL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 245 YGISVAIGNIWGGKLADKHGAVPALKFIFA--ALVVLLMIFQFTAsiqYAALVTVLVMGIFAFGNVPglqvYVVQKAERY 322
Cdd:pfam06779 237 FGLAAALGVLVWLRAAKRWGTRPALTAALLiqALGVLLSLLSPSP---AGLAVSSLLFGGTFMAITS----LVMQLAREL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489959941 323 TPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:pfam06779 310 APPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
5-181 |
3.78e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 42.60 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL 84
Cdd:cd17438 1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 85 AWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIA-----IMFGGLTVALVT---------GVPLGTFI 150
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSwlcmfWMIGGLYASAMAwsiiphygwGFSMGTNY 160
|
170 180 190
....*....|....*....|....*....|.
gi 489959941 151 GQHfGWReTFLAVSLLGVIALVASLLLVPSS 181
Cdd:cd17438 161 HFH-SWR-VFVIICALPCIASIIALKFMPES 189
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
29-178 |
4.88e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 4.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 29 IAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVF 108
Cdd:cd17329 227 VVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLV 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 109 FSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLV 178
Cdd:cd17329 307 FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
8-181 |
5.83e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 41.94 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd17439 4 LGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWR---------- 157
Cdd:cd17439 84 VQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSfqmgsayqfh 163
|
170 180
....*....|....*....|....*.
gi 489959941 158 --ETFLAVSLLGVIALVASLLLVPSS 181
Cdd:cd17439 164 swRVFVLVCAFPSVFAIGALTTMPES 189
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
10-172 |
8.19e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 8.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 10 ISAFAIGTTEFVIVGLVPTIAEQLAISLPS--AGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSsnSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGStIATSLVPKEKAASAIAIMfgglTVALVTGVPLGTFIGQHF------GWRETFL 161
Cdd:cd06179 82 AKSVNMLIGGQALIGIGAGTQGLGAA-VASELVPNKYRGLVQGVV----NLVASPGSALGPLIAGALveanaaGWRWIFY 156
|
170
....*....|.
gi 489959941 162 AVSLLGVIALV 172
Cdd:cd06179 157 INAIFNALALI 167
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
221-375 |
9.27e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.95 E-value: 9.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 221 TFLAPMMQELaGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYAALVTVLVM 300
Cdd:cd17337 18 GFLSPYLVDL-GFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVLFLAFGLPSHNYPLMLLTY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 301 GI-------FAFGNVpglqVYVVQKAErytPNAVDVASGLNIAAFNIGI-ALGSVIGGQTVEHVGLTQTPWIGAVIVLVA 372
Cdd:cd17337 97 GLrgfgyplFAYSFL----VWITYRTP---AERLGSAVGWFWFAFTGGLpVLGSYLASFTIPVIGEIGTLWLSLVFVALG 169
|
...
gi 489959941 373 FLL 375
Cdd:cd17337 170 GLI 172
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-221 |
9.58e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.05 E-value: 9.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLtglaHG 106
Cdd:PRK11102 15 PVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFL----HG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLV----PKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSS- 181
Cdd:PRK11102 91 LAAAAASVVINALMrdmfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETl 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 489959941 182 -----IPGRASASLSDQVKVLTHPRLLLIYAVTALGYGGVFTAFT 221
Cdd:PRK11102 171 pkerrQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLT 215
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
9-107 |
9.61e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.10 E-value: 9.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 9 TISAFAIGTTEFVIVGLVPTIAEQLAISLPSAG---LLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILA 85
Cdd:cd17360 3 GIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVM 82
|
90 100
....*....|....*....|..
gi 489959941 86 WQAPDYTTLVIARLLTGLAHGV 107
Cdd:cd17360 83 AAAPNKEVLIVGRVLVGLGVGI 104
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
5-150 |
1.34e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 40.69 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 5 LLALTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL 84
Cdd:cd17336 5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFL 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489959941 85 aWQAPDYttLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFI 150
Cdd:cd17336 85 -LALPHF--LFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFL 147
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
25-307 |
1.62e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.36 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQA-PDYTTLVIARLLTGL 103
Cdd:TIGR00886 24 AVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 104 AhGVFFSIGSTIATSLVPKEKAASAIAIM-----FGGLTVALVTGVPLGTFI-----GQHFGWRETFLAVS----LLGVI 169
Cdd:TIGR00886 104 A-GGSFASCMPWISFFFPKKIQGTALGLAagwgnMGGGVAQFVMPPIIGSLIfgggqPAHLAWGWAFVIVPagilLLPAL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 170 ALVASLLLVPSSIPGRASASLSDQVKVLTHPR---LLLIYAVTAlgygGVFTAFTFLAPMM-QELAGFSPGAVSWILLGY 245
Cdd:TIGR00886 183 LIFFVGADTPPGKPATGKLSFKEALKVFGNRHtwiLALLYSVTF----GSFLGVSSIFAMLfKDQFGLSKVQAGAYASLG 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489959941 246 GISVAIGNIWGGKLADKHGA--VPALKFIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGN 307
Cdd:TIGR00886 259 GFLGSLARPAGGAISDRLGGarKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGA 322
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
23-378 |
1.69e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 23 VGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTG 102
Cdd:cd17393 19 ATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 103 LAHGV----FFSIGSTIAT----SLVPKEKAASAIAIMFGGLTVALVTGvpLGTFIGQHFGwretfLAVSLLGVIALVAS 174
Cdd:cd17393 99 AANGAldvaMNAQGVAVERaygrPIMSSLHAMWSLGGLAGALLGAAAIG--AGVSPGVHLL-----AAAVLLLLAALVAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 175 LLLVPSSIPGRASASLSDQVK--VLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIG 252
Cdd:cd17393 172 RALLPGTGEAAEDRPDGAGKPgfLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 253 NIWGGKLADKHGAVPALKfIFAALVVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVDVASG 332
Cdd:cd17393 252 RLFGDRLVDRFGDVAVLR-AGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVAT 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489959941 333 LNIAAFNIGIALGSVIGgqtvEHVGLTQTPWIGAVIVLVAFLLIGL 378
Cdd:cd17393 331 LGYLGFLVGPPLIGFLA----DATGLRTAFLVVALLALLVALLARA 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
215-390 |
1.84e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.25 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 215 GVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIqYAAL 294
Cdd:COG2223 19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY-WLLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 295 VTVLVMGIFAFGNVPGLQVYVvqkAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQTPWIGAVI-----V 369
Cdd:COG2223 98 LLGLLLGIGGGGSFAVGIALV---SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILllvvaV 174
|
170 180
....*....|....*....|.
gi 489959941 370 LVAFLLIGLSGRLDKPARVAL 390
Cdd:COG2223 175 LAWLFLRDPPAGAAAAAKASL 195
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-180 |
1.98e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.85 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 26 VPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTT--LVIARLLTGL 103
Cdd:cd17380 22 IVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLplLILSRILLGL 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489959941 104 AHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPS 180
Cdd:cd17380 102 GEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPP 178
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
41-178 |
2.07e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.95 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVfFSIGSTIATSLV 120
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGN-VSLSTAIVADVT 145
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 489959941 121 PKEKAASAIAImfggLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLV 178
Cdd:cd17389 146 SPKKRSKGMAL----IGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFALVLAL 199
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
41-177 |
2.21e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.93 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQA-PDYTTLVIARLLTGLAHGVFFSIGSTIATSL 119
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEV 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489959941 120 VPKEKAASAIAIMFGGLTVALVTG--VPLGT-FIGQHFGWRETFLAVSLLGVIALVASLLL 177
Cdd:cd17356 128 APKHIRGTLVSLYQLAITIGILVAycINYGThKLDGSAQWRIPLGLQIVWGLLLLIGMFFL 188
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
8-181 |
2.45e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 39.78 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 8 LTISAFAIGTTEFVIVGLVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQ 87
Cdd:cd17363 4 LGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 88 APDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIA-----IMFGGLTVALVT---------GVPLGTFIGQH 153
Cdd:cd17363 84 VQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSwlcmfWMIGGLYASAMAwaiiphygwGFSMGTAYQFH 163
|
170 180
....*....|....*....|....*...
gi 489959941 154 fGWReTFLAVSLLGVIALVASLLLVPSS 181
Cdd:cd17363 164 -SWR-VFVIVCALPSVASVVALTFMPES 189
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
41-310 |
2.97e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.55 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNIL---AWQAPDYTTLVIARLLTGLAhgvffsigSTIAT 117
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLmflSKSAKSPELLIFGRFLVGIA--------CGLST 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 118 SLVPKEKAASAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETF---------LAVSLLGVIALVASLLLVPSSIP----- 183
Cdd:cd17357 124 GFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLgtetlwpylLFFPGIPALLQLAALPFFPESPKfllis 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 184 -GRASASLS------------DQV--------------------KVLTHP----RLLLIYAVTALGYGGVFTAFTFLAPM 226
Cdd:cd17357 204 kGDEEEAEKslkflrgieddvDQEleeikkeseqmgdqkqvslmQLLRDPslrlPLLLVLVVSASQQFSGINAIFFYSTF 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 227 MQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLMIFQFTASIQYA------ALVTVLVM 300
Cdd:cd17357 284 IFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQnswmsyGCIVAIFL 363
|
330
....*....|
gi 489959941 301 GIFAFGNVPG 310
Cdd:cd17357 364 FIFFFAIGLG 373
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
41-185 |
3.40e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 39.38 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 41 GLLVSIYALGVAVGAPVLTALTGRFARKKLLV---ALMVLFTAGNILAwqaPDYTTLVIARLLTGLAHGvffsiGSTIAT 117
Cdd:cd17377 42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLtglALDILFAYFNALA---PSYEFFAVSRFLVGVMNG-----GMSLVA 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489959941 118 SLVPKE---KAASAIAIMFGGLTVALvtGVPLGTFIGQHF-GWRETFLAVSLLGVIALVASLLlvpssIPGR 185
Cdd:cd17377 114 FVLLNEcvgKSYWALAGSLGGLFFAV--GIAQYALLGYFIrSWRTLAVVVNLQGTLVFLLSLF-----IPGR 178
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
45-104 |
3.63e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.94 E-value: 3.63e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 45 SIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLA 104
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMA 99
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
27-350 |
5.49e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 5.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 27 PTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAG-NILAWQAPDYTTLVIARLLTGLAH 105
Cdd:cd17314 27 QPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGyTYLSYVFNSFPLSYACFVFIGAGT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 106 GVFFSIGSTIATSLVPKEKAAsAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLVPSSiPGR 185
Cdd:cd17314 107 GILYGSAVLVTTQYFPDTKGL-ALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKE-PPD 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 186 ASASLSDQVK-------VLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGK 258
Cdd:cd17314 185 NQARLHVQKKktqtmgeIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGI 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 259 LADKHGAVPALKFIFAALvVLLMIFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVDVASGLNIAAF 338
Cdd:cd17314 265 VADFFGGRLSTLSILLTI-LGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAP 343
|
330
....*....|..
gi 489959941 339 NIGIALGSVIGG 350
Cdd:cd17314 344 AIGSILGPMLGA 355
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
42-354 |
5.79e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 38.58 E-value: 5.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 42 LLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIA-RLLTGLAHGVFFSIGSTIATSLV 120
Cdd:cd17422 42 WIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYLTiGIISGLGYCFTFLPTVTILSQYF 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 121 PKEKAAsAIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLLvpssipgrasaslsdqvKVLTHP 200
Cdd:cd17422 122 KKRRSL-VTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVCGALL-----------------RVLKEP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 201 RLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAvSWILLGYGISVAIGNIWGGKLADKHgavPALKFIFAALVVLL 280
Cdd:cd17422 184 GFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWA-AYMLSAMAIAELFGRISAGWVLNKC---PIRKIYIELICVIL 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489959941 281 M---IFQFTASIQYAALVTVLVMGIFAFGNVPGLQVYVVQKAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVE 354
Cdd:cd17422 260 LcvvLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVD 336
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
25-292 |
6.78e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.40 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 25 LVPTIAEQLAISLPSAGLLVSIYALGVAVGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLA 104
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 105 HGVFFSIGSTIATSLVPKEKAAS-AIAIMFGGLTVALVTGVPLGTFIGQHFGWRETFLAVSLLGVIALVASLLlvpssip 183
Cdd:cd17476 100 PAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 184 grasaslsdqvkvLTHPRLLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKh 263
Cdd:cd17476 173 -------------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIAR- 238
|
250 260
....*....|....*....|....*....
gi 489959941 264 gaVPAlkfifAALVVLLMIFQFTASIQYA 292
Cdd:cd17476 239 --LPP-----SYIMAISMVAFLVGPILFA 260
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
70-177 |
7.14e-03 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 38.24 E-value: 7.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 70 LLVALMVLFTAGNILAWQAPDYTTLVIARLLTGLAHGVFFSIGSTIATSLVPKEKAASAIAIMFGGLTVALVTGVPLGTF 149
Cdd:cd17465 258 LQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGL 337
|
90 100
....*....|....*....|....*...
gi 489959941 150 IGQHFGwrETFLAVSLLGVIALVASLLL 177
Cdd:cd17465 338 LHDYFG--SYHVAFYLAGVPPIIGGTVL 363
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
40-306 |
7.61e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.12 E-value: 7.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 40 AGLLVSIYALGVA-----VGAPVLTALTGRFARKKLLVALMVLFTAGNILAWQAPDYTT--------LVIARLLTGLAHG 106
Cdd:cd17368 37 ASLLLTFATFGVGffmrpIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 107 VFFSIGSTIATSLVPKEK---------AASAIAIMFGGLTVALVTGVpLGTFIGQHFGWRETFLAVSLLGVIALVASLLL 177
Cdd:cd17368 117 GEVGGVTAYLVEAAPPGRrgfytswqsASQQVAIVAGALVGYLLSLT-LTAEALAEWGWRIPFFIGLLIIPLGLWLRRSL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 178 V-PSSIPGRASASLSDQV--KVLTHPRLLLIYAVTALGYGGVFTAFTFLAPM-MQELAGFSPGAVSWILLGYGISVAIGN 253
Cdd:cd17368 196 EeTEAFLERKARPTRRELfaLLANNRRIILLGMLLVAGSTVTFYFTTVYTPTyAKTVLGLSARDSFLVTLLAGVANFIWA 275
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 489959941 254 IWGGKLADKHGAVPALkfIFAALVVLLMIFQ----FTASIQYAALVTVLVMGIFAFG 306
Cdd:cd17368 276 PLGGALSDRIGRRPVL--LVITLAALVTLYPvfawLTAAPSFGRLLLVLLVLSFFFG 330
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
202-389 |
9.82e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 37.93 E-value: 9.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 202 LLLIYAVTALGYGGVFTAFTFLAPMMQELAGFSPGAVSWILLGYGISVAIGNIWGGKLADKHGAVPALKFIFAALVVLLM 281
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959941 282 IFQFTASIQYAALVTVLVMGIFAFGNVPGLQVyvvqkAERYTPNAVDVASGLNIAAFNIGIALGSVIGGQTVEHVGLTQT 361
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGL-----IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180
....*....|....*....|....*...
gi 489959941 362 PWIGAVIVLVAFLLIGLSGRLDKPARVA 389
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAA 201
|
|
| |
