NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489959990|ref|WP_003863297|]
View 

MULTISPECIES: 50S ribosomal protein L18 [Enterobacteriaceae]

Protein Classification

50S ribosomal protein L18( domain architecture ID 17565799)

50S ribosomal protein L18 is part of the 5S rRNA/L5/L18/L25 subcomplex; it contacts 5S and 23S rRNAs

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 19-117 2.47e-44

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


:

Pssm-ID: 440026  Cd Length: 119  Bit Score: 140.23  E-value: 2.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  19 KELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQ 98
Cdd:COG0256   21 GTSERPRLVVFRSNKHIYAQIIDDTGGKTLASASTLEKELRKKLGSGGNTEAAYLVGKLIAERAKAKGIEEVVFDRGGYL 100

                         90
                 ....*....|....*....
gi 489959990  99 YHGRVQALADAAREAGLQF 117
Cdd:COG0256  101 YHGRVKALADGAREAGLKF 119
 
Name Accession Description Interval E-value
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 19-117 2.47e-44

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440026  Cd Length: 119  Bit Score: 140.23  E-value: 2.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  19 KELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQ 98
Cdd:COG0256   21 GTSERPRLVVFRSNKHIYAQIIDDTGGKTLASASTLEKELRKKLGSGGNTEAAYLVGKLIAERAKAKGIEEVVFDRGGYL 100

                         90
                 ....*....|....*....
gi 489959990  99 YHGRVQALADAAREAGLQF 117
Cdd:COG0256  101 YHGRVKALADGAREAGLKF 119
L18_bact TIGR00060
ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not ...
 3-117 8.05e-38

ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not detectable under this model. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 272881  Cd Length: 114  Bit Score: 123.39  E-value: 8.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990    3 KKSARIRRATRARRKLKELG---ATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAiseqLKYTGNKDAAAAVGKAVA 79
Cdd:TIGR00060   1 KKSARLRRHKRIRRKLRGTGeanRPRLVVFRSNRHIYAQVIDDVKGVTLASASTLEKK----LKSTGNKDAAKKVGKLVA 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489959990   80 ERALEKGISNVSFDRSGFQYHGRVQALADAAREAGLQF 117
Cdd:TIGR00060  77 ERLKEKGIKDVVFDRGGYKYHGRVAALAEAAREAGLNF 114
Ribosomal_L18p pfam00861
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large ...
 25-117 2.32e-36

Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.


Pssm-ID: 395691  Cd Length: 116  Bit Score: 119.77  E-value: 2.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990   25 RLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIseQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQYHGRVQ 104
Cdd:pfam00861  26 RLVVFRSNRHIYAQVIDDVKGHTLASASTLEKDL--KGLSGGNQDAAKKVGELIAERAKAKGITAVVFDRGGYKYHGRVA 103

                          90
                  ....*....|...
gi 489959990  105 ALADAAREAGLQF 117
Cdd:pfam00861 104 ALADAAREAGLNF 116
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 17-115 4.49e-33

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 111.09  E-value: 4.49e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  17 KLKELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSG 96
Cdd:cd00432    5 RLGTQERPRLVVRKSNKHIYAQIIDDSGDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIKKVVFDRGG 84

                         90
                 ....*....|....*....
gi 489959990  97 FQYHGRVQALADAAREAGL 115
Cdd:cd00432   85 YRYHGRVKALAKGAREGGL 103
rpl18 CHL00139
ribosomal protein L18; Validated
 25-117 1.38e-29

ribosomal protein L18; Validated


Pssm-ID: 214373  Cd Length: 109  Bit Score: 102.41  E-value: 1.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  25 RLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQYHGRVQ 104
Cdd:CHL00139  17 RLSVFRSNKHIYAQIIDDTNGKTLVACSTLEPDVKSSLSSTSTCDASKLVGQKLAKKSLKKGITKVVFDRGGKLYHGRIK 96

                         90
                 ....*....|...
gi 489959990 105 ALADAAREAGLQF 117
Cdd:CHL00139  97 ALAEAAREAGLQF 109
 
Name Accession Description Interval E-value
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 19-117 2.47e-44

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440026  Cd Length: 119  Bit Score: 140.23  E-value: 2.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  19 KELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQ 98
Cdd:COG0256   21 GTSERPRLVVFRSNKHIYAQIIDDTGGKTLASASTLEKELRKKLGSGGNTEAAYLVGKLIAERAKAKGIEEVVFDRGGYL 100

                         90
                 ....*....|....*....
gi 489959990  99 YHGRVQALADAAREAGLQF 117
Cdd:COG0256  101 YHGRVKALADGAREAGLKF 119
L18_bact TIGR00060
ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not ...
 3-117 8.05e-38

ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not detectable under this model. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 272881  Cd Length: 114  Bit Score: 123.39  E-value: 8.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990    3 KKSARIRRATRARRKLKELG---ATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAiseqLKYTGNKDAAAAVGKAVA 79
Cdd:TIGR00060   1 KKSARLRRHKRIRRKLRGTGeanRPRLVVFRSNRHIYAQVIDDVKGVTLASASTLEKK----LKSTGNKDAAKKVGKLVA 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489959990   80 ERALEKGISNVSFDRSGFQYHGRVQALADAAREAGLQF 117
Cdd:TIGR00060  77 ERLKEKGIKDVVFDRGGYKYHGRVAALAEAAREAGLNF 114
Ribosomal_L18p pfam00861
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large ...
 25-117 2.32e-36

Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.


Pssm-ID: 395691  Cd Length: 116  Bit Score: 119.77  E-value: 2.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990   25 RLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIseQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQYHGRVQ 104
Cdd:pfam00861  26 RLVVFRSNRHIYAQVIDDVKGHTLASASTLEKDL--KGLSGGNQDAAKKVGELIAERAKAKGITAVVFDRGGYKYHGRVA 103

                          90
                  ....*....|...
gi 489959990  105 ALADAAREAGLQF 117
Cdd:pfam00861 104 ALADAAREAGLNF 116
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 17-115 4.49e-33

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 111.09  E-value: 4.49e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  17 KLKELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSG 96
Cdd:cd00432    5 RLGTQERPRLVVRKSNKHIYAQIIDDSGDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIKKVVFDRGG 84

                         90
                 ....*....|....*....
gi 489959990  97 FQYHGRVQALADAAREAGL 115
Cdd:cd00432   85 YRYHGRVKALAKGAREGGL 103
rpl18 CHL00139
ribosomal protein L18; Validated
 25-117 1.38e-29

ribosomal protein L18; Validated


Pssm-ID: 214373  Cd Length: 109  Bit Score: 102.41  E-value: 1.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  25 RLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVAERALEKGISNVSFDRSGFQYHGRVQ 104
Cdd:CHL00139  17 RLSVFRSNKHIYAQIIDDTNGKTLVACSTLEPDVKSSLSSTSTCDASKLVGQKLAKKSLKKGITKVVFDRGGKLYHGRIK 96

                         90
                 ....*....|...
gi 489959990 105 ALADAAREAGLQF 117
Cdd:CHL00139  97 ALAEAAREAGLQF 109
PTZ00032 PTZ00032
60S ribosomal protein L18; Provisional
 25-117 3.10e-13

60S ribosomal protein L18; Provisional


Pssm-ID: 240235  Cd Length: 211  Bit Score: 62.96  E-value: 3.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489959990  25 RLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAISEQLKYTGNKDAAAAVGKAVA------------ERALEKGISNVSF 92
Cdd:PTZ00032 107 RLTLKNTNNQMYATIVDDYTRHVLCFSCTNFKYLSHIFGTYPTKTTNRVRNNGGTikaayelgkligRKALSKGISKVRF 186

                         90       100
                 ....*....|....*....|....*
gi 489959990  93 DRSGFQYHGRVQALADAAREAGLQF 117
Cdd:PTZ00032 187 DRAHYKYAGKVEALAEGARAVGLQF 211
rpl18p PRK08569
50S ribosomal protein L18P; Reviewed
 17-55 1.10e-03

50S ribosomal protein L18P; Reviewed


Pssm-ID: 236294 [Multi-domain]  Cd Length: 193  Bit Score: 36.83  E-value: 1.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 489959990  17 KLKELGATRLVVHRTPRHIYAQVI--APNGSEVLVAASTVE 55
Cdd:PRK08569  26 KLLLSGKPRLVVRKTNKHVIAQIVkyDPKGDRTLASAHSRE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH