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Conserved domains on  [gi|489960053|ref|WP_003863360|]
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MULTISPECIES: ornithine carbamoyltransferase [Enterobacter]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479748)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

EC:  2.1.3.3
Gene Ontology:  GO:0005737|GO:0016597|GO:0019546|GO:0004585|GO:0019547
PubMed:  27109103

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-334 0e+00

ornithine carbamoyltransferase; Validated


:

Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 704.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   1 MTINLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  81 SGSQIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSpgKTLPELSF 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 161 AYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGE 240
Cdd:PRK02102 159 AYVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 241 PKEaWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESPNSIVFDEAENR 320
Cdd:PRK02102 239 EDE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYGLKGLEVTDEVFESKYSIVFDEAENR 317

                        330
                 ....*....|....
gi 489960053 321 MHTIKAVMVATLGD 334
Cdd:PRK02102 318 MHTIKAVMVATLGD 331
 
Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-334 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 704.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   1 MTINLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  81 SGSQIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSpgKTLPELSF 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 161 AYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGE 240
Cdd:PRK02102 159 AYVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 241 PKEaWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESPNSIVFDEAENR 320
Cdd:PRK02102 239 EDE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYGLKGLEVTDEVFESKYSIVFDEAENR 317

                        330
                 ....*....|....
gi 489960053 321 MHTIKAVMVATLGD 334
Cdd:PRK02102 318 MHTIKAVMVATLGD 331
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 4-334 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 550.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS 83
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  84 QIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSpgKTLPELSFAYL 163
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHF--GKLKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 164 GDArNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKE 243
Cdd:COG0078  160 GDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 244 AwAERVSLMKPYQINADVMKATGnPNVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESPNSIVFDEAENRMHT 323
Cdd:COG0078  239 A-EERIKAFKPYQVNEELMALAK-PDAIFMHCLPAHRGE-----------------EVTDEVIDGPQSVVFDEAENRLHA 299

                        330
                 ....*....|.
gi 489960053 324 IKAVMVATLGD 334
Cdd:COG0078  300 QKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-333 1.05e-171

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 478.77  E-value: 1.05e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053    8 RNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGH 87
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   88 KESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPGktLPELSFAYLGDAr 167
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGK--LKGVKVVYVGDG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  168 NNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEpKEAWAE 247
Cdd:TIGR00658 158 NNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGE-EDKKEE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  248 RVSLMKPYQINADVMKATgNPNVKFMHCLPAFHnehtkvgreiemayglkGLEVTEEVFESPNSIVFDEAENRMHTIKAV 327
Cdd:TIGR00658 237 RLKLFRPYQVNEELMELA-KPEVIFMHCLPAHR-----------------GEEVTDEVIEGPHSIVFDQAENRLHAQKAV 298


                  ....*.
gi 489960053  328 MVATLG 333
Cdd:TIGR00658 299 MVALLG 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 8.34e-74

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 224.23  E-value: 8.34e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053    9 NFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGHK 88
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   89 ESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLE 148
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-334 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 704.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   1 MTINLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  81 SGSQIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSpgKTLPELSF 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 161 AYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGE 240
Cdd:PRK02102 159 AYVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 241 PKEaWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESPNSIVFDEAENR 320
Cdd:PRK02102 239 EDE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYGLKGLEVTDEVFESKYSIVFDEAENR 317

                        330
                 ....*....|....
gi 489960053 321 MHTIKAVMVATLGD 334
Cdd:PRK02102 318 MHTIKAVMVATLGD 331
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 4-332 0e+00

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 636.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS 83
Cdd:PRK03515   3 QFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  84 QIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPGKTLPELSFAYL 163
Cdd:PRK03515  83 QIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLAYA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 164 GDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKE 243
Cdd:PRK03515 163 GDARNNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 244 AWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYGLK-GLEVTEEVFESPNSIVFDEAENRMH 322
Cdd:PRK03515 243 VWAERIALLRPYQVNSKMMQLTGNPQVKFLHCLPAFHDDQTTLGKKMAEEYGLHgGMEVTDEVFESAHSIVFDQAENRLH 322

                        330
                 ....*....|
gi 489960053 323 TIKAVMVATL 332
Cdd:PRK03515 323 TIKAVMVATL 332
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 4-334 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 577.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS 83
Cdd:PRK04284   3 NLRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  84 QIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPgKTLPELSFAYL 163
Cdd:PRK04284  83 QMGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHLK-KPYKDIKFTYV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 164 GDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKE 243
Cdd:PRK04284 162 GDGRNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPDE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 244 AWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESPNSIVFDEAENRMHT 323
Cdd:PRK04284 242 VWEERIKLLKPYQVNKEMMKKTGNPNAIFEHCLPSFHDLDTKVGKEIFEKYGLKEMEVTDEVFESKASVVFDEAENRMHT 321

                        330
                 ....*....|.
gi 489960053 324 IKAVMVATLGD 334
Cdd:PRK04284 322 IKAVMVATLGE 332
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 1-332 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 556.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   1 MTINLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGP 80
Cdd:PRK01713   1 MAFNLKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  81 SGSQIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPgKTLPELSF 160
Cdd:PRK01713  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCD-KPLSEISY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 161 AYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGE 240
Cdd:PRK01713 160 VYIGDARNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 241 PKEAWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYG--LKGLEVTEEVFESPNSIVFDEAE 318
Cdd:PRK01713 240 PLETWGERIKLLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKVGRQIAEKYPelANGIEVTEDVFESPMNIAFEQAE 319

                        330
                 ....*....|....
gi 489960053 319 NRMHTIKAVMVATL 332
Cdd:PRK01713 320 NRMHTIKAVMVASL 333
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 4-334 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 550.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS 83
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  84 QIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSpgKTLPELSFAYL 163
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHF--GKLKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 164 GDArNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKE 243
Cdd:COG0078  160 GDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 244 AwAERVSLMKPYQINADVMKATGnPNVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESPNSIVFDEAENRMHT 323
Cdd:COG0078  239 A-EERIKAFKPYQVNEELMALAK-PDAIFMHCLPAHRGE-----------------EVTDEVIDGPQSVVFDEAENRLHA 299

                        330
                 ....*....|.
gi 489960053 324 IKAVMVATLGD 334
Cdd:COG0078  300 QKALLAWLLGG 310
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 4-333 0e+00

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 533.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS 83
Cdd:PRK12562   3 GFYKKHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  84 QIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPGKTLPELSFAYL 163
Cdd:PRK12562  83 QIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 164 GDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKE 243
Cdd:PRK12562 163 GDARNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPKE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 244 AWAERVSLMKPYQINADVMKATGNPNVKFMHCLPAFHNEHTKVGREIEMAYGLK-GLEVTEEVFESPNSIVFDEAENRMH 322
Cdd:PRK12562 243 KWAERIALLRGYQVNSKMMALTGNPQVKFLHCLPAFHDDQTTLGKKMAKEFGLHgGMEVTDEVFESPASIVFDQAENRMH 322

                        330
                 ....*....|.
gi 489960053 323 TIKAVMVATLG 333
Cdd:PRK12562 323 TIKAVMVATLA 333
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-333 1.05e-171

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 478.77  E-value: 1.05e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053    8 RNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGH 87
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   88 KESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPGktLPELSFAYLGDAr 167
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGK--LKGVKVVYVGDG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  168 NNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEpKEAWAE 247
Cdd:TIGR00658 158 NNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGE-EDKKEE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  248 RVSLMKPYQINADVMKATgNPNVKFMHCLPAFHnehtkvgreiemayglkGLEVTEEVFESPNSIVFDEAENRMHTIKAV 327
Cdd:TIGR00658 237 RLKLFRPYQVNEELMELA-KPEVIFMHCLPAHR-----------------GEEVTDEVIEGPHSIVFDQAENRLHAQKAV 298


                  ....*.
gi 489960053  328 MVATLG 333
Cdd:TIGR00658 299 MVALLG 304
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 4-332 1.23e-148

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 420.27  E-value: 1.23e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS 83
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  84 QIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHspGKTLPELSFAYL 163
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEH--RGSLKGLKVAWV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 164 GDArNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQcraIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKE 243
Cdd:PRK00779 159 GDG-NNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 244 AwAERVSLMKPYQINADVMKATgNPNVKFMHCLPAfHnehtkvgreiemayglKGLEVTEEVFESPNSIVFDEAENRMHT 323
Cdd:PRK00779 235 A-EERLKAFAPYQVNEELMALA-KPDAIFMHCLPA-H----------------RGEEVTDEVIDGPQSVVWDEAENRLHA 295


                 ....*....
gi 489960053 324 IKAVMVATL 332
Cdd:PRK00779 296 QKALLAWLL 304
PLN02342 PLN02342
ornithine carbamoyltransferase
 4-333 3.90e-106

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 314.04  E-value: 3.90e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAG-REKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSG 82
Cdd:PLN02342  42 KSKPKHFLHIDDFDKEEILGLLDRAKEVKALLKSGdRSFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  83 SQIGHKESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHS---PGKTLpels 159
Cdd:PLN02342 122 IQLGKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIgrlEGTKV---- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 160 fAYLGDArNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETgarITLTDDVEEGVQGTDFLYTDVWVSMG 239
Cdd:PLN02342 198 -VYVGDG-NNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVEKARAAGISK---IEITNDPAEAVKGADVVYTDVWASMG 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 240 EpKEAWAERVSLMKPYQINADVMKATGnPNVKFMHCLPAFhnehtkvgreiemayglKGLEVTEEVFESPNSIVFDEAEN 319
Cdd:PLN02342 273 Q-KEEAEKRKKAFQGFQVNEALMKLAG-PQAYFMHCLPAE-----------------RGVEVTDGVMEAPNSIVFPQAEN 333

                        330
                 ....*....|....
gi 489960053 320 RMHTIKAVMVATLG 333
Cdd:PLN02342 334 RMHAQNAIMLHQLG 347
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 10-334 2.06e-105

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 311.58  E-value: 2.06e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   10 FLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGHKE 89
Cdd:TIGR04384   2 FIDTNDFTKEEILDIIDLSLKIKEAIKDGYYPPLLKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGHE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   90 SMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSP-GKTLPELSFAYLGDArN 168
Cdd:TIGR04384  82 SIEDTARVLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEHLPaGKKLEDCKVVFVGDA-T 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  169 NMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMGEPKEAWAER 248
Cdd:TIGR04384 161 QVCVSLMFICTKMGMDFVHFGPKGYQIPEEWLAIAEANCKVSGGSVTVTDDVDEAVKGADFIYTDVWYGLYDQELSEEER 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  249 VSLMKP-YQINADVMkATGNPNVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESPNSIVFDEAENRMHTIKAV 327
Cdd:TIGR04384 241 MAIFYPkYQVNPELM-AKAGPHAKFMHCLPASRGE-----------------EVTDEVMDSPQSICFDEAENRLTAIRAL 302


                  ....*..
gi 489960053  328 MVATLGD 334
Cdd:TIGR04384 303 LVYFLYP 309
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 8-333 4.55e-91

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 274.26  E-value: 4.55e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   8 RNFLKLLDYTPAEIQYLIDLAIELKAAKKAGRekQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGH 87
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKANPAEYR--QALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  88 KESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPgkTLPELSFAYLGDAr 167
Cdd:PRK14805  80 RESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFG--DVSKVKLAYVGDG- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 168 NNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEgVQGTDFLYTDVWVSMGEPKeAWAE 247
Cdd:PRK14805 157 NNVTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLTSDIEA-IEGHDAIYTDTWISMGDDT-PLAE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 248 RVSLMKPYQINADVMKATGNPNvkFMHCLPAFhnehtkvgreiemayglKGLEVTEEVFESPNSIVFDEAENRMHTIKAV 327
Cdd:PRK14805 235 IKAKFAPYQVNKALMEKAGATF--VMHCQPAH-----------------RGVEITSEVMDGEGSLILQQAENRMHAQNAV 295


                 ....*.
gi 489960053 328 MVATLG 333
Cdd:PRK14805 296 LVTLLS 301
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 8.34e-74

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 224.23  E-value: 8.34e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053    9 NFLKLLDYTPAEIQYLIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGHK 88
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   89 ESMKDTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLE 148
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
160-331 3.30e-71

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 217.86  E-value: 3.30e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  160 FAYLGDARNNMGNSLMVGAAKMGMDIRLVAPKSFWPEAGLVEQCRAIAKETGARITLTDDVEEGVQGTDFLYTDVWVSMG 239
Cdd:pfam00185   2 IAYVGDGHNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSMG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  240 EPKEaWAERVSLMKPYQINADVMKATGnPNVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESPNSIVFDEAEN 319
Cdd:pfam00185  82 QEKE-REERLKAFKPYQVNEELMKLAK-KDAIFMHCLPAHRGE-----------------EVTDDVFDGPRSVVFDQAEN 142

                         170
                  ....*....|..
gi 489960053  320 RMHTIKAVMVAT 331
Cdd:pfam00185 143 RLHAQKALLALL 154
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 15-332 3.79e-50

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 169.44  E-value: 3.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  15 DYTPAEIQYLIDLAIELKAAK--KAGRekqtLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIgHKESMK 92
Cdd:PRK14804  14 DWSDSEILDLLDFAVHVKKNRvnYAGH----MSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNF-QLSDID 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  93 DTARVLGRMYDGIEYRGYGQAIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHSPGKTLPELSFAYLGdARNNMGN 172
Cdd:PRK14804  89 LEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIALDSPEIPLNQKQLTYIG-VHNNVVN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 173 SLMVGAAKMGMDIRLVAP----KSFWPEAglVEqcRAIAKETgarITLTDDVEEGVQGTDFLYTDVWVSM---GEPKEA- 244
Cdd:PRK14804 168 SLIGITAALGIHLTLVTPiaakENIHAQT--VE--RAKKKGT---LSWEMNLHKAVSHADYVYTDTWLDMeffNDPSYAd 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 245 -WAERVSLMKPYQINADVMKATgnpNVKFMHCLPaFHnehtkvgreiemayglKGLEVTEEVFESPNSIVFDEAENRMHT 323
Cdd:PRK14804 241 kKKQRMELMMPYQINSSLMEKT---NAKVMHDMP-IH----------------AGYEITREVVLSDRSIIFQQAENRLDA 300


                 ....*....
gi 489960053 324 IKAVMVATL 332
Cdd:PRK14804 301 QKAVILKLL 309
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 8-328 2.70e-46

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 159.91  E-value: 2.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   8 RNFLKLLDYTPAEIQYLIDLAielkAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGS--QI 85
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQA----AAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPGKDawPI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  86 GHK----------ESMKDTARVLGRMYDGIEYRGYGQ----------AIVEELGEYAGVPVWNGLTDEfHPTQILADLMT 145
Cdd:PRK04523  80 EFElgavmdgeteEHIREVARVLSRYVDLIGVRAFPKfvdwskdrqdQVLNSFAKYSTVPVINMETIT-HPCQELAHALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 146 MLEH----SPGKTLPeLSFAY----LGDArnnMGNSLMVGAAKMGMDIRLVAPK-SFWPEAGLVEQCRAIAKETGARITL 216
Cdd:PRK04523 159 LQEHfgttLRGKKYV-LTWTYhpkpLNTA---VANSALLIATRLGMDVTLLCPTpDYILDERYMDWAEQNAAESGGSLTV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 217 TDDVEEGVQGTDFLYTDVWvsmGEPK--EAWAERVSLMKPYQ---INADVMKATGNpnVKFMHCLPAFHNehtkvgreie 291
Cdd:PRK04523 235 SHDIDSAYAGADVVYAKSW---GALPffGNWEPEKPIRDQYQhfiVDERKMALTNN--GVFSHCLPLRRN---------- 299

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489960053 292 mayglkgLEVTEEVFESPNSIVFDEAENRMHTIKAVM 328
Cdd:PRK04523 300 -------VKVTDAVMDSPNCIAIDEAENRLHVQKAIM 329
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
4-328 1.03e-34

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 128.65  E-value: 1.03e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKAGREK-QTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSG 82
Cdd:PRK00856   2 PLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKvPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  83 SQIGHKESMKDTARVLGRMY-DGIEYR----GYgqaiVEELGEYAGVPVWNGlTD---EfHPTQILADLMTMLEHspGKT 154
Cdd:PRK00856  82 SSVSKGETLADTIRTLSAMGaDAIVIRhpqsGA----ARLLAESSDVPVINA-GDgshQ-HPTQALLDLLTIREE--FGR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 155 LPELSFAYLGD------ARnnmgnSLMVGAAKMGMDIRLVAPKSFWPEAglVEQCRaiaketgaritLTDDVEEGVQGTD 228
Cdd:PRK00856 154 LEGLKVAIVGDikhsrvAR-----SNIQALTRLGAEVRLIAPPTLLPEG--MPEYG-----------VHTDLDEVIEDAD 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 229 FLYTdvw--vsMGEPKEAWAERVSlmKPYQINADVMKATgNPNVKFMHCLPafhnehtkVGREIEMAYglkglevteEVF 306
Cdd:PRK00856 216 VVMMlrvqkerMDGGLLPSYEEYK--RSYGLTAERLALA-KPDAIVMHPGP--------VNRGVEIAS---------DVA 275

                        330       340
                 ....*....|....*....|....*.
gi 489960053 307 ESPNSIVFDEAEN----RMhtikAVM 328
Cdd:PRK00856 276 DGPQSVIFEQVTNgvavRM----AVL 297
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 4-330 2.14e-21

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 93.65  E-value: 2.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053   4 NLKNRNFLKLLDYTPAEIQYLIDLAIELKAAKKagREKQTLV---GKNIALiFEKTSTRTRCAFEVGAFDQGAQVTYLGP 80
Cdd:PRK07200  17 HMHEKDFLLTWEKTPDELKAVLDVADALRALRE--ENISTKVfnsGLGISV-FRDNSTRTRFSYASACNLLGLEVQDLDE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  81 SGSQIGHKESMKDTARVLGRMYDGIEYR-----GYGQAIVEELGEY------AGV----PVWNGL-TDEFHPTQILADLM 144
Cdd:PRK07200  94 GKSQIAHGETVRETANMISFMADVIGIRddmyiGKGNAYMREVGAAvddgykQGVlpqrPTLVNLqCDIDHPTQSMADLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 145 TMLEHS------PGKTLPeLSFAYlgdaRNNMGNSLMV--GAA----KMGMDIRLVAPKSF--WPEagLVEQCRAIAKET 210
Cdd:PRK07200 174 HLIEHFgglenlKGKKIA-MTWAY----SPSYGKPLSVpqGIIglmtRFGMDVTLAHPEGYdlMPE--VVEVAKKNAKAS 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 211 GARITLTDDVEEGVQGTDFLYTDVWVsmgePKEAWAERVSLM----------------------KPYQINADVMKATGNP 268
Cdd:PRK07200 247 GGSFRQVNSMEEAFKDADIVYPKSWA----PYKVMEERTELYragdhegikalekellaqnaqhKDWHCTEEMMKLTKDG 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489960053 269 NVKFMHCLPAfhnEHTKVGREiemayglKGlEVTEEVFESPNSIVFDEAENRMHTIKAVMVA 330
Cdd:PRK07200 323 KALYMHCLPA---DISGVSCK-------EG-EVTESVFDRYRIALYKEASWKPYIIAAMIFL 373
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 37-277 2.26e-15

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 75.92  E-value: 2.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  37 AGREKQTLV--GKNIALIFEKTSTRTRCAFEVgAFDQ-GAQVT-YLGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYGQ 112
Cdd:PRK08192  33 ALREKRTRVleGAILGNLFFEPSTRTRVSFGC-AFNLlGGHVReTTGMASSSLSKGESLYDTARVLSTYSDVIAMRHPDA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 113 AIVEELGEYAGVPVWNG--LTDEfHPTQILADLMTM---LEHSpGKTLPELSFAYLGDARNnmGNSLMVGAAKMGM--DI 185
Cdd:PRK08192 112 GSVKEFAEGSRVPVINGgdGSNE-HPTQALLDLFTIqkeLAHA-GRGIDGMHIAMVGDLKF--GRTVHSLSRLLCMykNV 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 186 R--LVAPKSFWPEAGLVEQCRAiakeTGARITLTDDVEEGVQGTDFLYTdvwVSMGEPKEAWAERVSLMK-PYQINADVM 262
Cdd:PRK08192 188 SftLVSPKELAMPDYVISDIEN----AGHKITITDQLEGNLDKADILYL---TRIQEERFPSQEEANKYRgKFRLNQSIY 260

                        250
                 ....*....|....*
gi 489960053 263 KATGNPNVKFMHCLP 277
Cdd:PRK08192 261 TQHCKSNTVIMHPLP 275
pyrB PRK13814
aspartate carbamoyltransferase;
42-196 3.70e-14

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 72.06  E-value: 3.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  42 QTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSGSQIGHKESMKDTARVLGRMydGIEY---RGYGQAIVEEL 118
Cdd:PRK13814  41 ETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISKGETLFDTIKTLEAM--GVYFfivRHSENETPEQI 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 119 GEY--AGVPVWNGLTDEFHPTQILADLMTMLEHSPGKTlpELSFAYLGDARNN-MGNSLMVGAAKMGM-DIRLVAPKSFW 194
Cdd:PRK13814 119 AKQlsSGVVINAGDGNHQHPSQALIDLMTIKQHKPHWN--KLCVTIIGDIRHSrVANSLMDGLVTMGVpEIRLVGPSSLL 196


                 ..
gi 489960053 195 PE 196
Cdd:PRK13814 197 PD 198
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 37-277 7.64e-14

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 71.82  E-value: 7.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  37 AGREKQT--LVGKNIALIFEKTSTRTRCAFEvGAFDQ--GAQVTYLGPSGSQIGHKESMKDTARVLGRMYDGIEYRGYGQ 112
Cdd:PRK11891 115 ARRQKISrvLEGAVLGNLFFEASTRTRVSFG-AAFCRlgGSVCDTTGFTFSSMAKGESIYDTSRVMSGYVDALVIRHPEQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 113 AIVEELGEYAGVPVWNGLTDEF-HPTQILADLMTML-EHSP-GKTLPELSFAYLGDARNNMG-NSLM-VGAAKMGMDIRL 187
Cdd:PRK11891 194 GSVAEFARATNLPVINGGDGPGeHPSQALLDLYTIQrEFSRlGKIVDGAHIALVGDLKYGRTvHSLVkLLALYRGLKFTL 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 188 VAPKSFWPEAGLVEQcraiAKETGARITLTDDVEEGVQGTDFLY-TDVwvsmgePKEAWA--ERVSLMKPYQINADVMKA 264
Cdd:PRK11891 274 VSPPTLEMPAYIVEQ----ISRNGHVIEQTDDLAAGLRGADVVYaTRI------QKERFAdeSFEGYTPDFQINQALVDA 343

                        250
                 ....*....|...
gi 489960053 265 TGNPNVKFMHCLP 277
Cdd:PRK11891 344 VCKPDTLIMHPLP 356
PLN02527 PLN02527
aspartate carbamoyltransferase
 24-334 5.62e-10

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 59.38  E-value: 5.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053  24 LIDLAIELKAAKKAGREKQTLVGKNIALIFEKTSTRTRCAFEVGAFDQGAQVTYLGPSG--SQIGHKESMKDTARVLGRM 101
Cdd:PLN02527  17 LFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAGefSSAAKGETLEDTIRTVEGY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 102 YDGIEYRGYGQAIVEELGEYAGVPVWN-GLTDEFHPTQILADLMTmLEHSPGKtLPELSFAYLGDARNNMG-NSLMVGAA 179
Cdd:PLN02527  97 SDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYT-IQREIGR-LDGIKVGLVGDLANGRTvRSLAYLLA 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 180 KM-GMDIRLVAPKSFWPEAGLVEQCRAiakeTGARITLTDDVEEGVQGTDFLY-TDVwvsmgePKEAWAERVSLMKP--- 254
Cdd:PLN02527 175 KYeDVKIYFVAPDVVKMKDDIKDYLTS----KGVEWEESSDLMEVASKCDVLYqTRI------QRERFGERIDLYEAarg 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489960053 255 -YQINADVMKATgNPNVKFMHCLPAFHnehtkvgreiemayglkglEVTEEVFESPNSIVFDEAENRMHTIKAVMVATLG 333
Cdd:PLN02527 245 kYIVDKKVMDVL-PKHAVVMHPLPRLD-------------------EITTDVDSDPRAAYFRQAKNGLFIRMALLKLLLG 304


                 .
gi 489960053 334 D 334
Cdd:PLN02527 305 G 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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