YcaO-like family protein may be involved in azoline formation, macroamidine formation, thioamide formation, and/or potentiation of RimO-dependent methylthiolation; similar to Mycobacterium tuberculosis protein Rv1375
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate ...
66-436
0e+00
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved]
:
Pssm-ID: 273224 Cd Length: 377 Bit Score: 535.58 E-value: 0e+00
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate ...
66-436
0e+00
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved]
Pssm-ID: 273224 Cd Length: 377 Bit Score: 535.58 E-value: 0e+00
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved ...
115-424
2.74e-58
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyses ATP to AMP and pyrophosphate.
Pssm-ID: 426884 Cd Length: 318 Bit Score: 193.66 E-value: 2.74e-58
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate ...
66-436
0e+00
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved]
Pssm-ID: 273224 Cd Length: 377 Bit Score: 535.58 E-value: 0e+00
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved ...
115-424
2.74e-58
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyses ATP to AMP and pyrophosphate.
Pssm-ID: 426884 Cd Length: 318 Bit Score: 193.66 E-value: 2.74e-58
thiazole/oxazole-forming peptide maturase, SagD family component; Members of this protein ...
116-424
2.19e-21
thiazole/oxazole-forming peptide maturase, SagD family component; Members of this protein family include enzymes related to SagD, previously referred to as a scaffold or docking protein involved in the biosynthesis of streptolysin S in Streptococcus pyogenes from the protoxin polypeptide (product of the sagA gene). Newer evidence describes an enzymatic activity, an ATP-dependent cyclodehydration reaction, previously ascribed to the SagC component. This protein family serves as a marker for widely distributed prokaryotic systems for making a general class of heterocycle-containing bacteriocins.
Pssm-ID: 274674 Cd Length: 377 Bit Score: 95.09 E-value: 2.19e-21
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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