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Conserved domains on  [gi|489997671|ref|WP_003900676|]
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MULTISPECIES: sensor histidine kinase [Mycobacterium]

Protein Classification

sensor histidine kinase( domain architecture ID 11428750)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
408-633 2.79e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 99.60  E-value: 2.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 408 EETRLRLLVNEMFETMSRRSRSlvdqQLSVI----DQLERNEE--DPARLDSLFRLDHLAARLRRNSANLLVLAG--AQI 479
Cdd:COG2205    8 ELEELERLKSEFLANVSHELRT----PLTSIlgaaELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRleSGK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 480 TRDHREPVPLSTVISAAVSEVED-----YRRVDIARVPDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIgSE 554
Cdd:COG2205   84 LSLELEPVDLAELLEEAVEELRPlaeekGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR-EG 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489997671 555 GSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG2205  163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIW----VESEPGGGTTFTVTLPLA 237
COG4251 super family cl34744
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
171-633 1.16e-07

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4251:

Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 55.18  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 171 LLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAG 250
Cdd:COG4251   16 LLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 251 SPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIA 330
Cdd:COG4251   96 LLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAAL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 331 TAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVDELHTRALLLAGEET 410
Cdd:COG4251  176 AELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 411 RLRLLVNEMFETMSRRSRSLVD--QQL-------------------SVIDQLERNEEDpaRLDSlfRLDHLAARLRRNSA 469
Cdd:COG4251  256 ELRLELEELEEELEERTAELERsnEELeqfayvashdlreplrkisGFSQLLEEDYGD--KLDE--EGREYLERIRDAAE 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 470 -------NLLVLAGAQITRDHREPVPLSTVISAAVSEVE---DYRRVDIaRVPDCAVVGAAAGGVIHLLAELIDNALRYS 539
Cdd:COG4251  332 rmqalidDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEpriEERGAEI-EVGPLPTVRGDPTLLRQVFQNLISNAIKYS 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 540 SPTTPVRVA-AAIGSEGSVLLRISDSGLG--MTDADR------RMANMRLRAG-GevtpdsarhMGLFVVGRLAGRHGIR 609
Cdd:COG4251  411 RPGEPPRIEiGAEREGGEWVFSVRDNGIGidPEYAEKifeifqRLHSRDEYEGtG---------IGLAIVKKIVERHGGR 481
                        490       500
                 ....*....|....*....|....
gi 489997671 610 VGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG4251  482 IW----VESEPGEGATFYFTLPKA 501
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
408-633 2.79e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 99.60  E-value: 2.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 408 EETRLRLLVNEMFETMSRRSRSlvdqQLSVI----DQLERNEE--DPARLDSLFRLDHLAARLRRNSANLLVLAG--AQI 479
Cdd:COG2205    8 ELEELERLKSEFLANVSHELRT----PLTSIlgaaELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRleSGK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 480 TRDHREPVPLSTVISAAVSEVED-----YRRVDIARVPDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIgSE 554
Cdd:COG2205   84 LSLELEPVDLAELLEEAVEELRPlaeekGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR-EG 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489997671 555 GSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG2205  163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIW----VESEPGGGTTFTVTLPLA 237
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
526-633 7.44e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 71.14  E-value: 7.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671   526 HLLAELIDNALRYSSPTTPVRVAAAIgSEGSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSARH-MGLFVVGRLAG 604
Cdd:smart00387   8 QVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTgLGLSIVKKLVE 86
                           90       100
                   ....*....|....*....|....*....
gi 489997671   605 RHGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:smart00387  87 LHGGEIS----VESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
526-633 5.74e-13

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 65.85  E-value: 5.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671  526 HLLAELIDNALRYSSPTTPVRVaaAIGSEGSVLLRISDSGLGMTDADRRMANMRLrAGGEVTPDSARHMGLFVVGRLAGR 605
Cdd:pfam02518   8 QVLSNLLDNALKHAAKAGEITV--TLSEGGELTLTVEDNGIGIPPEDLPRIFEPF-STADKRGGGGTGLGLSIVRKLVEL 84
                          90       100
                  ....*....|....*....|....*...
gi 489997671  606 HGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:pfam02518  85 LGGTIT----VESEPGGGTTVTLTLPLA 108
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
171-633 1.16e-07

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 55.18  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 171 LLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAG 250
Cdd:COG4251   16 LLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 251 SPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIA 330
Cdd:COG4251   96 LLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAAL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 331 TAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVDELHTRALLLAGEET 410
Cdd:COG4251  176 AELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 411 RLRLLVNEMFETMSRRSRSLVD--QQL-------------------SVIDQLERNEEDpaRLDSlfRLDHLAARLRRNSA 469
Cdd:COG4251  256 ELRLELEELEEELEERTAELERsnEELeqfayvashdlreplrkisGFSQLLEEDYGD--KLDE--EGREYLERIRDAAE 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 470 -------NLLVLAGAQITRDHREPVPLSTVISAAVSEVE---DYRRVDIaRVPDCAVVGAAAGGVIHLLAELIDNALRYS 539
Cdd:COG4251  332 rmqalidDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEpriEERGAEI-EVGPLPTVRGDPTLLRQVFQNLISNAIKYS 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 540 SPTTPVRVA-AAIGSEGSVLLRISDSGLG--MTDADR------RMANMRLRAG-GevtpdsarhMGLFVVGRLAGRHGIR 609
Cdd:COG4251  411 RPGEPPRIEiGAEREGGEWVFSVRDNGIGidPEYAEKifeifqRLHSRDEYEGtG---------IGLAIVKKIVERHGGR 481
                        490       500
                 ....*....|....*....|....
gi 489997671 610 VGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG4251  482 IW----VESEPGEGATFYFTLPKA 501
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
527-630 7.09e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 48.56  E-value: 7.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 527 LLAELIDNALRYSSPTTpvRVAAAIGSEGSVLLRISDSGLGMTDADRRMANMRL-RAGGEVTPDSArhMGLFVVGRLAGR 605
Cdd:cd16940   17 LLRNLVDNAVRYSPQGS--RVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFyRSDGQNYGGSG--LGLSIVKRIVEL 92
                         90       100
                 ....*....|....*....|....*
gi 489997671 606 HGIRVGLrGPVtgeQGTGTTAEVYL 630
Cdd:cd16940   93 HGGQIFL-GNA---QGGGLEAWVRL 113
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
408-633 2.79e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 99.60  E-value: 2.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 408 EETRLRLLVNEMFETMSRRSRSlvdqQLSVI----DQLERNEE--DPARLDSLFRLDHLAARLRRNSANLLVLAG--AQI 479
Cdd:COG2205    8 ELEELERLKSEFLANVSHELRT----PLTSIlgaaELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRleSGK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 480 TRDHREPVPLSTVISAAVSEVED-----YRRVDIARVPDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIgSE 554
Cdd:COG2205   84 LSLELEPVDLAELLEEAVEELRPlaeekGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR-EG 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489997671 555 GSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG2205  163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIW----VESEPGGGTTFTVTLPLA 237
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
317-633 9.79e-17

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 82.26  E-value: 9.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 317 AAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVD 396
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 397 ELHTRALLLAGEETRLRLLVNEMFETMSRRSRSLVD------QQLSVID---QLERNEEDPARLDSLFRLDHLAARLRRN 467
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANvshelrTPLTAIRgylELLLEELDEEQREYLETILRSADRLLRL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 468 SANLLVLA--GAQITRDHREPVPLSTVISAAVSEVEDY---RRVDIA-RVPDCAVVGAAAGGVIH-LLAELIDNALRYSS 540
Cdd:COG0642  161 INDLLDLSrlEAGKLELEPEPVDLAELLEEVVELFRPLaeeKGIELElDLPDDLPTVRGDPDRLRqVLLNLLSNAIKYTP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 541 PTTPVRVAAAIgSEGSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGlrgpVTGEQ 620
Cdd:COG0642  241 EGGTVTVSVRR-EGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIE----VESEP 315
                        330
                 ....*....|...
gi 489997671 621 GTGTTAEVYLPLA 633
Cdd:COG0642  316 GKGTTFTVTLPLA 328
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
526-633 7.44e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 71.14  E-value: 7.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671   526 HLLAELIDNALRYSSPTTPVRVAAAIgSEGSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSARH-MGLFVVGRLAG 604
Cdd:smart00387   8 QVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTgLGLSIVKKLVE 86
                           90       100
                   ....*....|....*....|....*....
gi 489997671   605 RHGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:smart00387  87 LHGGEIS----VESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
526-633 5.74e-13

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 65.85  E-value: 5.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671  526 HLLAELIDNALRYSSPTTPVRVaaAIGSEGSVLLRISDSGLGMTDADRRMANMRLrAGGEVTPDSARHMGLFVVGRLAGR 605
Cdd:pfam02518   8 QVLSNLLDNALKHAAKAGEITV--TLSEGGELTLTVEDNGIGIPPEDLPRIFEPF-STADKRGGGGTGLGLSIVRKLVEL 84
                          90       100
                  ....*....|....*....|....*...
gi 489997671  606 HGIRVGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:pfam02518  85 LGGTIT----VESEPGGGTTVTLTLPLA 108
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
257-633 9.59e-09

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 58.41  E-value: 9.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 257 LQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVV 336
Cdd:COG5002   15 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 337 LVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVDELHTRALllagEETRLRLLV 416
Cdd:COG5002   95 LLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERL----EQMRREFVA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 417 N------------EMF-ETMSRRSRSLVDQQLSVIDQLERNeedparldslfrldhlAARLRRNSANLLVLA--GAQITR 481
Cdd:COG5002  171 NvshelrtpltsiRGYlELLLDGAADDPEERREYLEIILEE----------------AERLSRLVNDLLDLSrlESGELK 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 482 DHREPVPLSTVISAAVSEVEDY---RRVDI-ARVPDCAVVGAAAGGVIH-LLAELIDNALRYSSPTTPVRVAAAIgSEGS 556
Cdd:COG5002  235 LEKEPVDLAELLEEVVEELRPLaeeKGIELeLDLPEDPLLVLGDPDRLEqVLTNLLDNAIKYTPEGGTITVSLRE-EDDQ 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 557 VLLRISDSGLGMTDADRRmanmRL-----RAggevtpDSARH-------MGLFVVGRLAGRHGIRVGlrgpVTGEQGTGT 624
Cdd:COG5002  314 VRISVRDTGIGIPEEDLP----RIferfyRV------DKSRSretggtgLGLAIVKHIVEAHGGRIW----VESEPGKGT 379

                 ....*....
gi 489997671 625 TAEVYLPLA 633
Cdd:COG5002  380 TFTITLPLA 388
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
171-633 1.16e-07

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 55.18  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 171 LLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAG 250
Cdd:COG4251   16 LLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 251 SPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIA 330
Cdd:COG4251   96 LLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAAL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 331 TAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVDELHTRALLLAGEET 410
Cdd:COG4251  176 AELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 411 RLRLLVNEMFETMSRRSRSLVD--QQL-------------------SVIDQLERNEEDpaRLDSlfRLDHLAARLRRNSA 469
Cdd:COG4251  256 ELRLELEELEEELEERTAELERsnEELeqfayvashdlreplrkisGFSQLLEEDYGD--KLDE--EGREYLERIRDAAE 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 470 -------NLLVLAGAQITRDHREPVPLSTVISAAVSEVE---DYRRVDIaRVPDCAVVGAAAGGVIHLLAELIDNALRYS 539
Cdd:COG4251  332 rmqalidDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEpriEERGAEI-EVGPLPTVRGDPTLLRQVFQNLISNAIKYS 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 540 SPTTPVRVA-AAIGSEGSVLLRISDSGLG--MTDADR------RMANMRLRAG-GevtpdsarhMGLFVVGRLAGRHGIR 609
Cdd:COG4251  411 RPGEPPRIEiGAEREGGEWVFSVRDNGIGidPEYAEKifeifqRLHSRDEYEGtG---------IGLAIVKKIVERHGGR 481
                        490       500
                 ....*....|....*....|....
gi 489997671 610 VGlrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG4251  482 IW----VESEPGEGATFYFTLPKA 501
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
527-630 7.09e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 48.56  E-value: 7.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 527 LLAELIDNALRYSSPTTpvRVAAAIGSEGSVLLRISDSGLGMTDADRRMANMRL-RAGGEVTPDSArhMGLFVVGRLAGR 605
Cdd:cd16940   17 LLRNLVDNAVRYSPQGS--RVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFyRSDGQNYGGSG--LGLSIVKRIVEL 92
                         90       100
                 ....*....|....*....|....*
gi 489997671 606 HGIRVGLrGPVtgeQGTGTTAEVYL 630
Cdd:cd16940   93 HGGQIFL-GNA---QGGGLEAWVRL 113
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
318-633 6.78e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 49.46  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 318 AIRDAVLVLAAIATaIVVVLVVARTLVG-----------PMRVLRDGALKVAHTDLDGEIAAVRAgdePIpeplaVYTTE 386
Cdd:COG3290   92 SIREGVIAVDRDGR-ITLINDAARRLLGldaigrpidevLAEVLETGERDEEILLNGRVLVVNRV---PI-----RDDGR 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 387 EIGQVAHAVDelHTRALLLAGEETRLRLLVNEMfetmsrrsRSlvdQ------QLSVID---QLERNEEDPARLDSLFR- 456
Cdd:COG3290  163 VVGAVATFRD--RTELERLEEELEGVKELAEAL--------RA---QrhdfrnHLHTISgllQLGEYDEALEYIDEISEe 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 457 LDHLAARLRRNSANLlVLAGaqitrdhrepvplstVISAAVSEVEDYR-RVDIARVPDCAVVGAAAGGVIHLLAELIDNA 535
Cdd:COG3290  230 LQELIDSLLSRIGNP-VLAA---------------LLLGKAARARERGiDLTIDIDSDLPDLPLSDTDLVTILGNLLDNA 293
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 536 LRY--SSPTTPVRVAAAIGSEGS-VLLRISDSGLGMTDADRRmanmRLRAGGEVTPDSARH-MGLFVVGRLAGRHGIRVG 611
Cdd:COG3290  294 IEAveKLPEEERRVELSIRDDGDeLVIEVEDSGPGIPEELLE----KIFERGFSTKLGEGRgLGLALVKQIVEKYGGTIE 369
                        330       340
                 ....*....|....*....|..
gi 489997671 612 lrgpVTGEQGTGTTAEVYLPLA 633
Cdd:COG3290  370 ----VESEEGEGTVFTVRLPKE 387
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
323-632 1.04e-05

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 48.86  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 323 VLVLAAIATAIVVVLVVARTLVGPMRVLRDGALKVAHTDLdgeiaavragdepipEPLAVYTTEEIGQVAHAVDELHTRA 402
Cdd:COG2972  161 LIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL---------------VRLEVSGNDEIGILARSFNEMVERI 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 403 LLLAGEETRLRLLVNEMfetmsrRSRSLvDQQ---------LSVIDQLERnEEDPARLDSLfrLDHLAARLRRNsanllv 473
Cdd:COG2972  226 KELIEEVYELELEKKEA------ELKAL-QAQinphflfntLNSIRWLAE-LEDPEEAEEM--LEALSKLLRYS------ 289
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 474 lagaqiTRDHREPVPLSTVISAAVS--EVEDYR-------RVDI------ARVPdcavvgaaaggvIHLLAELIDNALRY 538
Cdd:COG2972  290 ------LSKGDELVTLEEELELIKSylEIQKLRfgdrlevEIEIdeelldLLIP------------KLILQPLVENAIEH 351
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 539 S-SPTTP---VRVAAAIgSEGSVLLRISDSGLGMTDADRRmanmRLRAGGEVTPDSaRHMGLF-VVGRLAGRHGIRVGLR 613
Cdd:COG2972  352 GiEPKEGggtIRISIRK-EGDRLVITVEDNGVGMPEEKLE----KLLEELSSKGEG-RGIGLRnVRERLKLYYGEEYGLE 425
                        330
                 ....*....|....*....
gi 489997671 614 gpVTGEQGTGTTAEVYLPL 632
Cdd:COG2972  426 --IESEPGEGTTVTIRIPL 442
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
112-628 9.19e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 46.26  E-value: 9.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 112 AQKNFTARKYELQTRLADTDVIADVRSGVNTLLNGGQALLDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIR 191
Cdd:COG2770    5 LLALLLLLLLLLLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 192 TQVQGLSRAVGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDP 271
Cdd:COG2770   85 VALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAAL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 272 AVALVNNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVLR 351
Cdd:COG2770  165 ALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 352 DGALKVAHTDLDGEIaavragdepipeplAVYTTEEIGQVAHAVDELhTRALLLAGEETRLRLLVNEMFETMSRRSRSLV 431
Cdd:COG2770  245 EAARRIAAGDLDVRI--------------PVSRKDEIGELARAFNRM-ADSLRESIEEAEEEEELAEAELARLLEALLEL 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 432 DQQLSVIDQLERNEEDPARLDSLFRLDHLAARLRRNSANLLVLAGAQITRDHREPVPLSTVISAAVSEVEDYRRVDIARV 511
Cdd:COG2770  310 LLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELA 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 512 PDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIGSEGSVLLRISDSGLGMTDADRRMANMRLRAGGEVTPDSA 591
Cdd:COG2770  390 AVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAA 469
                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 489997671 592 RHMGLFVVGRLAGRHGIRVGLRGPVTGEQGTGTTAEV 628
Cdd:COG2770  470 EALLLLAALLLLAALGALELLLLEEEEEAGAAAEELA 506
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
525-631 3.11e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 40.73  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 525 IHLLAELIDNALRYSSPTTPV--RVAAAIGSEGS-VLLRISDSGLGMTDADRRMANMRlraGGEVTPDSARHMGLFVVGR 601
Cdd:cd16915    2 ITIVGNLIDNALDALAATGAPnkQVEVFLRDEGDdLVIEVRDTGPGIAPELRDKVFER---GVSTKGQGERGIGLALVRQ 78
                         90       100       110
                 ....*....|....*....|....*....|
gi 489997671 602 LAGRHGIRVglrgPVTGEQGTGTTAEVYLP 631
Cdd:cd16915   79 SVERLGGSI----TVESEPGGGTTFSIRIP 104
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
141-398 9.96e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 42.70  E-value: 9.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 141 NTLLNGGQALLDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGADL 220
Cdd:COG0840    4 LLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 221 AEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTT 300
Cdd:COG0840   84 LLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 301 EAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGdepipepl 380
Cdd:COG0840  164 AALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKD-------- 235
                        250
                 ....*....|....*...
gi 489997671 381 avytteEIGQVAHAVDEL 398
Cdd:COG0840  236 ------EIGQLADAFNRM 247
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
126-636 3.06e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 41.04  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 126 RLADTDVIADVRSGVNTLLNGGQALLDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARG 205
Cdd:COG3920   19 LAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAAL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 206 QMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSI 285
Cdd:COG3920   99 ALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 286 QITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGE 365
Cdd:COG3920  179 LLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLL 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 366 IAAVRAGDEPIpeplavytteEIGQVAHAVDELHTRALLLAGEETRLRLLVNEmfetMSRRSR-------SLVDQQLsvi 438
Cdd:COG3920  259 LLLLLLRALLL----------LAAGIRLVITERKRAEEELEASLEEKELLLRE----LHHRVKnnlqvvsSLLRLQA--- 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 439 dqleRNEEDPARLDSlfrLDHLAARLRrnsanllVLAGAQ---ITRDHREPVPLSTVISAAVSEVED-YRRVDIARVPDC 514
Cdd:COG3920  322 ----RRADDPEAREA---LEESQNRIQ-------ALALVHellYQSEDWEGVDLRDYLRELLEPLRDsYGGRGIRIELDG 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997671 515 AVVGAAAGGVIHL---LAELIDNALRYSSPTTP---VRVAAAIgSEGSVLLRISDSGLGMTDadrrmanmrlraggEVTP 588
Cdd:COG3920  388 PDVELPADAAVPLgliLNELVTNALKHAFLSGEggrIRVSWRR-EDGRLRLTVSDNGVGLPE--------------DVDP 452
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 489997671 589 DSARHMGLFVVGRLAGRhgirvgLRGPVTGEQGTGTTAEVYLPLAVLE 636
Cdd:COG3920  453 PARKGLGLRLIRALVRQ------LGGTLELDRPEGTRVRITFPLAELA 494
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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