|
Name |
Accession |
Description |
Interval |
E-value |
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
11-280 |
5.04e-80 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 243.30 E-value: 5.04e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 11 LQDEIRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMFKQHLMEETANYT 90
Cdd:COG1737 7 LLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 91 ERARLfrqtttddaTPPETPTEILNMFTMVNTQALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALR 170
Cdd:COG1737 87 RLRRL---------SPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 171 HLDRKAFLIDGLGGMFTEQLSLVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVCFVVREAQ 250
Cdd:COG1737 158 RLGKNVVLLDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEE 237
|
250 260 270
....*....|....*....|....*....|....
gi 490199639 251 VD----GFRSQVASLCLAQTLAVSLALNSSKDAE 280
Cdd:COG1737 238 PTlrssAFSSRVAQLALIDALAAAVAQRDGDKAR 271
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
135-270 |
4.54e-36 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 125.80 E-value: 4.54e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 135 DDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALRHLDRKAFLIDGLGGMFTEQLSLvGPKDVVVAVSFSPYAREVVEL 214
Cdd:cd05013 1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANL-TPGDVVIAISFSGETKETVEA 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 215 VELGAQRKARQIAITDSQVSPLAAFSDVCFVVREAQVD----GFRSQVASLCLAQTLAVS 270
Cdd:cd05013 80 AEIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDfrssAFSSRIAQLALIDALFLA 139
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
143-270 |
4.26e-23 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 91.59 E-value: 4.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 143 LLAEAENIYVIGLRRSFSVASYLTYALRHLDRKAFLIDGLGGMFTEQLSLVGPKDVVVAVSFSPYAREVVELVELGAQRK 222
Cdd:pfam01380 1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490199639 223 ARQIAITDSQVSPLAAFSDVCF---VVREAQVDGFRSQVASLCLAQTLAVS 270
Cdd:pfam01380 81 AKIIAITDSPGSPLAREADHVLyinAGPETGVASTKSITAQLAALDALAVA 131
|
|
| PRK14101 |
PRK14101 |
bifunctional transcriptional regulator/glucokinase; |
13-273 |
1.16e-17 |
|
bifunctional transcriptional regulator/glucokinase;
Pssm-ID: 184507 [Multi-domain] Cd Length: 638 Bit Score: 82.66 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 13 DEIRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMFKQHLMEETANYTER 92
Cdd:PRK14101 345 ERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHSQ 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 93 ARLFRQTTTDDATppetpteILNmftmvNT-QALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYalrH 171
Cdd:PRK14101 425 VHLGDTATDFGAK-------VLD-----NTvSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHY---K 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 172 LDRKAFLIDGLGGMFTEQLS--LVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITdSQVSPLAAFSDVCFVV--- 246
Cdd:PRK14101 490 FFRFGIPTIAYGDLYMQAASaaLLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAIT-SSNTPLAKRATVALETdhi 568
|
250 260
....*....|....*....|....*....
gi 490199639 247 --REAQVDgFRSQVASLCLAQTLAVSLAL 273
Cdd:PRK14101 569 emRESQLS-MISRILHLVMIDILAVGVAI 596
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
11-280 |
5.04e-80 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 243.30 E-value: 5.04e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 11 LQDEIRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMFKQHLMEETANYT 90
Cdd:COG1737 7 LLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 91 ERARLfrqtttddaTPPETPTEILNMFTMVNTQALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALR 170
Cdd:COG1737 87 RLRRL---------SPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 171 HLDRKAFLIDGLGGMFTEQLSLVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVCFVVREAQ 250
Cdd:COG1737 158 RLGKNVVLLDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEE 237
|
250 260 270
....*....|....*....|....*....|....
gi 490199639 251 VD----GFRSQVASLCLAQTLAVSLALNSSKDAE 280
Cdd:COG1737 238 PTlrssAFSSRVAQLALIDALAAAVAQRDGDKAR 271
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
135-270 |
4.54e-36 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 125.80 E-value: 4.54e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 135 DDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALRHLDRKAFLIDGLGGMFTEQLSLvGPKDVVVAVSFSPYAREVVEL 214
Cdd:cd05013 1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANL-TPGDVVIAISFSGETKETVEA 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 215 VELGAQRKARQIAITDSQVSPLAAFSDVCFVVREAQVD----GFRSQVASLCLAQTLAVS 270
Cdd:cd05013 80 AEIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDfrssAFSSRIAQLALIDALFLA 139
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
143-270 |
4.26e-23 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 91.59 E-value: 4.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 143 LLAEAENIYVIGLRRSFSVASYLTYALRHLDRKAFLIDGLGGMFTEQLSLVGPKDVVVAVSFSPYAREVVELVELGAQRK 222
Cdd:pfam01380 1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490199639 223 ARQIAITDSQVSPLAAFSDVCF---VVREAQVDGFRSQVASLCLAQTLAVS 270
Cdd:pfam01380 81 AKIIAITDSPGSPLAREADHVLyinAGPETGVASTKSITAQLAALDALAVA 131
|
|
| PRK14101 |
PRK14101 |
bifunctional transcriptional regulator/glucokinase; |
13-273 |
1.16e-17 |
|
bifunctional transcriptional regulator/glucokinase;
Pssm-ID: 184507 [Multi-domain] Cd Length: 638 Bit Score: 82.66 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 13 DEIRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMFKQHLMEETANYTER 92
Cdd:PRK14101 345 ERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHSQ 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 93 ARLFRQTTTDDATppetpteILNmftmvNT-QALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYalrH 171
Cdd:PRK14101 425 VHLGDTATDFGAK-------VLD-----NTvSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHY---K 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 172 LDRKAFLIDGLGGMFTEQLS--LVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITdSQVSPLAAFSDVCFVV--- 246
Cdd:PRK14101 490 FFRFGIPTIAYGDLYMQAASaaLLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAIT-SSNTPLAKRATVALETdhi 568
|
250 260
....*....|....*....|....*....
gi 490199639 247 --REAQVDgFRSQVASLCLAQTLAVSLAL 273
Cdd:PRK14101 569 emRESQLS-MISRILHLVMIDILAVGVAI 596
|
|
| PRK11337 |
PRK11337 |
MurR/RpiR family transcriptional regulator; |
15-242 |
2.72e-16 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183089 [Multi-domain] Cd Length: 292 Bit Score: 77.11 E-value: 2.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 15 IRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMFKQHLMEETANYTErar 94
Cdd:PRK11337 19 IRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDYFSQSEQVLHS--- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 95 lfrqtttdDATPPETPTEILNMFTMVNTQALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALRHLDR 174
Cdd:PRK11337 96 --------ELSFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGV 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490199639 175 KAFLIDGLGGMFTEQlSLVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDV 242
Cdd:PRK11337 168 RCQAYDDAHIMLMSA-ALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADY 234
|
|
| PRK11302 |
PRK11302 |
DNA-binding transcriptional regulator HexR; Provisional |
13-243 |
6.58e-14 |
|
DNA-binding transcriptional regulator HexR; Provisional
Pssm-ID: 183082 [Multi-domain] Cd Length: 284 Bit Score: 70.02 E-value: 6.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 13 DEIRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEmkqmFKQHLMEETANYTer 92
Cdd:PRK11302 5 EKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPD----FKLHLAQSLANGT-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 93 ARLFRQTTTDDAtpPETPTEILNMFTMVN-TQALQQLAMQTsgddLQRAVALLAEAENIYVIGLRRSFSVAsyltyalrh 171
Cdd:PRK11302 79 PYVNRNVEEDDS--VEAYTGKIFESAMASlDHARQSLDPSA----INRAVDLLTQAKKISFFGLGASAAVA--------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 172 ldrkaflIDGLGGMFTEQLSLV---------------GPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITdSQVSPL 236
Cdd:PRK11302 144 -------HDAQNKFFRFNVPVVyfddivmqrmscmnsSDGDVVVLISHTGRTKSLVELAQLARENGATVIAIT-SAGSPL 215
|
....*..
gi 490199639 237 AAFSDVC 243
Cdd:PRK11302 216 AREATLA 222
|
|
| PRK11557 |
PRK11557 |
MurR/RpiR family transcriptional regulator; |
15-271 |
1.45e-10 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183195 [Multi-domain] Cd Length: 278 Bit Score: 60.55 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 15 IRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMFKQHLMEETAnyTERAR 94
Cdd:PRK11557 3 IRQRYPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPE--PPSVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 95 LFRQTTTDDatPPETPTEILnmfTMVNTQALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALRHLDR 174
Cdd:PRK11557 81 VHNQIRGDD--PLRLVGEKL---IKENTAAMRATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 175 KAFLIDGLGGMFTEQLSLvGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVC-FVVREAQVDg 253
Cdd:PRK11557 156 NAVAERDMHALLATVQAL-SPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHClYTIAEEQAT- 233
|
250
....*....|....*...
gi 490199639 254 fRSQVASLCLAQTLAVSL 271
Cdd:PRK11557 234 -RSAAISSTHAQGMLTDL 250
|
|
| HTH_6 |
pfam01418 |
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ... |
15-88 |
1.09e-09 |
|
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.
Pssm-ID: 334531 [Multi-domain] Cd Length: 77 Bit Score: 53.87 E-value: 1.09e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490199639 15 IRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEmkqmFKQHLMEETAN 88
Cdd:pfam01418 7 IQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPE----LKLALAGELAN 76
|
|
| PRK15482 |
PRK15482 |
HTH-type transcriptional regulator MurR; |
14-241 |
1.22e-09 |
|
HTH-type transcriptional regulator MurR;
Pssm-ID: 185379 [Multi-domain] Cd Length: 285 Bit Score: 57.79 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 14 EIRRRYDTLSKRLKQVARYILDNSNSVAFDTVASIAQQADVPPSTLIRFANAFGFSGFNEMKQMfkqhLMEETANYTERA 93
Cdd:PRK15482 6 KIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMA----LIGEYSASREKT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 94 R-----LFRQTTTDDATppETPTEILNMFTMVntqALQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYA 168
Cdd:PRK15482 82 NatalhLHSSITSDDSL--EVIARKLNREKEL---ALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFK 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490199639 169 LRHLD-RKAFLIDGLGGMFTEQLSLVGpkDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSD 241
Cdd:PRK15482 157 LMKIGyRVACEADTHVQATVSQALKKG--DVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAH 228
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
123-285 |
1.05e-08 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 55.29 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 123 QALQQLAMQtSGDDLQRAVALLAEA--ENIYVIGLRRSFSVASYLTYALRHLDRKAFLIDGLGGMFTEQLSLVGPKDVVV 200
Cdd:COG2222 9 EAWRRALAA-LAAAIAALLARLRAKppRRVVLVGAGSSDHAAQAAAYLLERLLGIPVAALAPSELVVYPAYLKLEGTLVV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 201 AVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVCFVVREAQVDGF---RSQVASLCLAQTLAVSLALNSSK 277
Cdd:COG2222 88 AISRSGNSPEVVAALELAKARGARTLAITNNPDSPLAEAADRVLPLPAGPEKSVaatKSFTTMLLALLALLAAWGGDDAL 167
|
....*...
gi 490199639 278 DAETKQLA 285
Cdd:COG2222 168 LAALDALP 175
|
|
| SIS_PHI |
cd05005 |
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
125-261 |
1.14e-08 |
|
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.
Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 53.73 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 125 LQQLAMQTSGDDLQRAVALLAEAENIYVIGLRRSFSVASYLTYALRHLDRKAFLIdglGGMFTEQLslvGPKDVVVAVSF 204
Cdd:cd05005 11 IENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVV---GETTTPAI---GPGDLLIAISG 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490199639 205 SPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVCFVVREAQVDGFRSQVASL 261
Cdd:cd05005 85 SGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSI 141
|
|
| SIS_Kpsf |
cd05014 |
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ... |
190-270 |
2.76e-08 |
|
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.
Pssm-ID: 240145 [Multi-domain] Cd Length: 128 Bit Score: 51.39 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 190 LSLVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDV---CFVVREAQVDGFR---SQVASLCL 263
Cdd:cd05014 42 LGMVTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSDVvldLPVEEEACPLGLApttSTTAMLAL 121
|
....*..
gi 490199639 264 AQTLAVS 270
Cdd:cd05014 122 GDALAVA 128
|
|
| SIS |
cd04795 |
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
150-230 |
1.58e-05 |
|
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240112 [Multi-domain] Cd Length: 87 Bit Score: 42.36 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 150 IYVIGLRRSFSVASYLTYALRHLDRK-AFLIDGLGGMFTEQLSLVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAI 228
Cdd:cd04795 1 IFVIGIGGSGAIAAYFALELLELTGIeVVALIATELEHASLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80
|
..
gi 490199639 229 TD 230
Cdd:cd04795 81 TD 82
|
|
| GutQ |
COG0794 |
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ... |
123-249 |
5.04e-05 |
|
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440557 [Multi-domain] Cd Length: 317 Bit Score: 44.20 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 123 QALQQLAmQTSGDDLQRAVALLAEAEN-IYVIGLRRSFSVASYLTYALRHLDRKAFLIDG-------LGgmfteqlsLVG 194
Cdd:COG0794 20 EALAALA-ERLDESFEKAVELILNCKGrVVVTGMGKSGHIARKIAATLASTGTPAFFLHPaeashgdLG--------MIT 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 490199639 195 PKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVCF---VVREA 249
Cdd:COG0794 91 PGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLdlpVEREA 148
|
|
| SIS_1 |
cd05710 |
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ... |
193-245 |
5.62e-05 |
|
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240214 [Multi-domain] Cd Length: 120 Bit Score: 41.79 E-value: 5.62e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 490199639 193 VGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAITDSQVSPLAAFSDVCFV 245
Cdd:cd05710 45 LTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDEDSPLAKLADYVIV 97
|
|
| SIS_PGI_PMI_1 |
cd05017 |
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ... |
193-229 |
6.38e-04 |
|
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.
Pssm-ID: 240148 [Multi-domain] Cd Length: 119 Bit Score: 38.79 E-value: 6.38e-04
10 20 30
....*....|....*....|....*....|....*..
gi 490199639 193 VGPKDVVVAVSFSPYAREVVELVELGAQRKARQIAIT 229
Cdd:cd05017 41 VDRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVAIT 77
|
|
| SIS_GlmS_GlmD_1 |
cd05008 |
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
149-272 |
1.49e-03 |
|
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.
Pssm-ID: 240141 [Multi-domain] Cd Length: 126 Bit Score: 37.86 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 149 NIYVIGLRRSFSVASYLTYAL-RHLDRKAFLIdgLGGMFTEQLSLVGPKDVVVAVSFSPYAREVVELVELGAQRKARQIA 227
Cdd:cd05008 1 RILIVGCGTSYHAALVAKYLLeRLAGIPVEVE--AASEFRYRRPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVA 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490199639 228 ITDSQVSPLAAFSDVCFVVR---EAQVD---GFRSQVASLCLaqtLAVSLA 272
Cdd:cd05008 79 ITNVVGSTLAREADYVLYLRagpEISVAatkAFTSQLLALLL---LALALA 126
|
|
| gutQ |
PRK11543 |
arabinose-5-phosphate isomerase GutQ; |
134-271 |
7.69e-03 |
|
arabinose-5-phosphate isomerase GutQ;
Pssm-ID: 183186 [Multi-domain] Cd Length: 321 Bit Score: 37.44 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490199639 134 GDDLQRAVALLAEAE-NIYVIGLRRSFSVASYLTYALRHLDRKAFLI---DGLGGmfteQLSLVGPKDVVVAVSFSPYAR 209
Cdd:PRK11543 28 GDDFVRAANIILHCEgKVVVSGIGKSGHIGKKIAATLASTGTPAFFVhpaEALHG----DLGMIESRDVMLFISYSGGAK 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490199639 210 EVVELVELGAQRKARQIAITDSQVSPLA----AFSDVCfVVREA---QVDGFRSQVASLCLAQTLAVSL 271
Cdd:PRK11543 104 ELDLIIPRLEDKSIALLAMTGKPTSPLGlaakAVLDIS-VEREAcpmHLAPTSSTVNTLMMGDALAMAV 171
|
|
| |
