|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-437 |
0e+00 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 571.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 27 RMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 107 VNVGLGFS----TAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGT 182
Cdd:cd17345 81 INILIGFVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 183 EHWQSAsYIVPACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLKTKHNQQapeNMSAFQIFCTYVLRNKNAWYV 262
Cdd:cd17345 161 GWWRGA-FIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQ---ELSAWEIFVKYVLKNKLLWYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 263 SFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIG 342
Cdd:cd17345 237 AIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 343 YWKSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGGFYLL 422
Cdd:cd17345 317 YWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVL 396
|
410
....*....|....*
gi 490203636 423 MGGIVCCILFCYLSH 437
Cdd:cd17345 397 LASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-419 |
9.80e-157 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 449.13 E-value: 9.80e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 35 FLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFS 114
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 115 TAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEHWQsasYIVPA 194
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV---FIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 195 CVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEkvvlKTKHNQQAPENMSAFQIFCTYVLRNKNAWYVSFVDVFVYMVRF 274
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE----PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 275 GMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWK--SESLLMV 352
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 353 TVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLfGVMVDKMGWHGGF 419
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPL-GYLADGFGWAGAF 379
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-455 |
9.05e-110 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 332.06 E-value: 9.05e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 1 MLSLLKKGPSANKVPAEKIQATYGRYRMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQlDLSATQIGLLSSCMLIAYGIS 80
Cdd:PRK11273 1 MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 81 KGVMSSLADKASPKVFMACGLVLCAIVNVGLGF----STAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGA 156
Cdd:PRK11273 80 KFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 157 FWNISHNVGGGIVAPIVgaafaILG---TEHWQSASYiVPACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLKT 233
Cdd:PRK11273 160 VWNCAHNVGGGLPPLLF-----LLGmawFNDWHAALY-MPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 234 KHNQQapenMSAFQIFCTYVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLA 313
Cdd:PRK11273 234 KHEQE----LTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLC 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 314 GWLSDKLFKGRRMPLAMICMALIFICLIGYW----KSESLLMVTVFAaiVGCLIYVPQFLASVQTMEIVPSFAVGSAVGL 389
Cdd:PRK11273 310 GWMSDKVFRGNRGATGVFFMTLVTIATIVYWlnpaGNPTVDMACMIV--IGFLIYGPVMLIGLHALELAPKKAAGTAAGF 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490203636 390 RGFMSYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYLSHRGalELEQQRKITEQEEA 455
Cdd:PRK11273 388 TGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIG--EKRHHEELLQKRNG 451
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
28-431 |
1.58e-80 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 256.90 E-value: 1.58e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 28 MQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:PRK09556 28 MQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAIC 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 108 NVGLGFS-----TAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIvapivGAAFAILGT 182
Cdd:PRK09556 108 MLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAG-----AGGVALWGA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 183 EHWQSAS----YIVPACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKvvlkTKHNQQAPEN-MSAFQIFCTYVLRNK 257
Cdd:PRK09556 183 NYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPI----SEEDKETESTdMTKWQIFVEYVLKNP 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 258 NAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfKGRRMPLAMICMALIF 337
Cdd:PRK09556 259 VIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRALVACIALALII 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 338 ICLIGYWKSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASL--------------GT 403
Cdd:PRK09556 338 FTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFakvglgmiadptknGT 417
|
410 420
....*....|....*....|....*...
gi 490203636 404 SLFGVMVDkmGWHGGFYLLMGGIVCCIL 431
Cdd:PRK09556 418 PIFGYTLT--GWAGTFAALDIAAIGCIC 443
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-433 |
5.53e-80 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 252.19 E-value: 5.53e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 27 RMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 107 VNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehWQ 186
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG---WR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 187 SAsYIVPACVAVVFAIsvlvlgkgspreeglpsleemmpeekVVLKTKHNqqapenmsafqifctyvlRNKNAWYVSFVD 266
Cdd:cd17312 158 AA-FLVPGIVGLVVAI--------------------------ILFFFLRD------------------SPPYVWVLSLAY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 267 VFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKS 346
Cdd:cd17312 193 AFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFF 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 347 -ESLLMVTVFAAIVGCLIYVPQ-FLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFYLLMG 424
Cdd:cd17312 273 pHNKLLSIVLLFLIGFFVGGPInLIGGAAAQDIGRKEAAGTATGFVGLFGYL-GASLAGLPLGYIIDHYGWSTVFYFLIS 351
|
....*....
gi 490203636 425 GIVCCILFC 433
Cdd:cd17312 352 AALLSVLLL 360
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
16-419 |
2.09e-63 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 211.49 E-value: 2.09e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 16 AEKIQATYGRYRMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKV 95
Cdd:PRK11663 10 KHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 96 FMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGA 175
Cdd:PRK11663 90 FMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 176 AFAILGtehWQsASYIVPACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLKTKHNQqapeNMSAFQIFCTYVLR 255
Cdd:PRK11663 170 IALHYG---WR-YGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGA----GLSRKEILTKYVLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 256 NKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMAL 335
Cdd:PRK11663 242 NPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 336 IFICLIGYW--KSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKM 413
Cdd:PRK11663 322 ILLSVGSLWlmPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLEIW 400
|
....*.
gi 490203636 414 GWHGGF 419
Cdd:PRK11663 401 HWTGFF 406
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-438 |
2.66e-63 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 208.96 E-value: 2.66e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 20 QATYGRYRMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMAC 99
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 100 GLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAI 179
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 180 LGtehWQSAsYIVPACVAVVFAISVLvlgkgspreeglpsleemmpeekvvlktkhnqqapenmsafqifctyvlrnkna 259
Cdd:COG2271 161 FG---WRAA-FLILGLPGLLLALLRF------------------------------------------------------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 260 WYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKgRRMPLAMICMALIFIC 339
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-RRKLVLAIGLLLAALA 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 340 LIGYWKSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGF 419
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL-GGALGPLLVGYLLDATGYQAAF 340
|
410
....*....|....*....
gi 490203636 420 YLLMGGIVCCILFCYLSHR 438
Cdd:COG2271 341 LLLAALALLAALLALLLLR 359
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
27-422 |
1.85e-56 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 191.08 E-value: 1.85e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 27 RMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 107 VNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehWQ 186
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG---WR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 187 SASYiVPACVAVVFAISVLVLGKGSPReeglpsleemmpeekvvlktkhnqqapenmsafqifctYVlrnknaWYVSFVD 266
Cdd:cd17488 158 AGMY-VPGIIAILMGIVLCWRLRDRPP--------------------------------------YI------WLLAFCY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 267 VFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYW-- 344
Cdd:cd17488 193 VLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWlv 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490203636 345 KSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYiFGASLGTSLFGVMVDKMGWHGGFYLL 422
Cdd:cd17488 273 PVHSYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAY-LGAALAGYPLAKVIESWGWSGFFIVI 349
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-435 |
3.37e-37 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 139.63 E-value: 3.37e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 25 RYRMQALLsvFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:cd17319 1 RWRIIPLL--FLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 105 AIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGaafAILGTEH 184
Cdd:cd17319 79 SLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG---WLLLLFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 185 WQSAsYIVPACVAVVFAISVLVLGkgspreeglpsleemmpeekvvlktkhnqqapenmsafqifctyvlrnKNAWYVSF 264
Cdd:cd17319 156 WRWA-FIIEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLAL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 265 VDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVaflffeWAAIP------STLLAGWLSDKLFKGRRMPLAMICMALIFI 338
Cdd:cd17319 187 GYFGINYALYGLLTWLPTYLKQARGFSLKQVGL------LAAIPflagaiGMILGGRLSDRLLRGARRLVIIIGLLLAAV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 339 CLIGYWKSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGG 418
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYLVDATGSYTA 339
|
410
....*....|....*..
gi 490203636 419 FYLLMGGIVCCILFCYL 435
Cdd:cd17319 340 AFLFLAAVALLAALLVL 356
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-422 |
1.23e-36 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 139.01 E-value: 1.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17343 5 FASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRErgrVGAFWNI---SHNVGGGiVAPIVGaafAILGTEHWQS 187
Cdd:cd17343 85 FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ---FGTWWSVlstSMNLAGS-LGPILA---TLLALSYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 188 ASYIVPACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLKTKHNQQAPEnmsafqifctyVLRNKNAWYVSFVDV 267
Cdd:cd17343 158 STLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKE-----------LLLSPFLWLLSLGYL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGR--------RMPLAMICMALI--F 337
Cdd:cd17343 227 VVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHgsssrgnpRMPLALVFMAGLtvS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 338 ICLIGYWKSE--SLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYiFGASLGTSLFGVMVDKMGW 415
Cdd:cd17343 307 LHLFRVHITSdsSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAKHYDW 385
|
....*..
gi 490203636 416 HGGFYLL 422
Cdd:cd17343 386 RTAFLLL 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-434 |
2.24e-32 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 126.77 E-value: 2.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 34 VFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGF 113
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 114 STAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGTEHWQSASYIVp 193
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSV-GGILGPLLGGILASSLGFGWRAVFLIA- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 194 ACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLKTkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFVYMVR 273
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKR-------------------VLKNPGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 274 FGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFkgRRMPLAMICMALIFICLIGYWKSESLLMVT 353
Cdd:cd06174 220 YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI--GRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 354 VFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFC 433
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 490203636 434 Y 434
Cdd:cd06174 378 L 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-435 |
3.35e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 126.53 E-value: 3.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 25 RYRMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 105 AIVNVGLGFSTAFWIFAALvvlnGLFQGMGVGPSFI----TIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAIL 180
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLL----GLLLGIGGGGSFAvgiaLVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 181 GtehWQSAsYIVPACVAVVFAISVLVLGKGSPREEglpsleemmpeekvvlktkhNQQAPENMSAFQIfctyVLRNKNAW 260
Cdd:COG2223 157 G---WRNA-FLILGILLLVVAVLAWLFLRDPPAGA--------------------AAAAKASLRDQLE----ALRDPRFW 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 261 YVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICL 340
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 341 IGYWKSESLLMVTVFAAIVGCLIYVPQFLASVqtMEIVPSFAVGSAVGLrGFMSYIFGASLGTSLFGVMVDKMG-WHGGF 419
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALV--PDIFPTKNAGAVYGL-VGAAGGLGGFLGPLLFGALLDATGsYTAAF 365
|
410
....*....|....*.
gi 490203636 420 YLLMGGIVCCILFCYL 435
Cdd:COG2223 366 LVFAVLALVALVLTLL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-403 |
3.48e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 122.91 E-value: 3.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 34 VFLGYLAYYIVRNNFTLSTP-YLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLG 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 113 FSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehWQSAsYIV 192
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---WRAA-FLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 193 PACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVlktkhnqqapenmsafqifcTYVLRNKNAWYVsFVDVFVYMV 272
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW--------------------KALLRDPVLWLL-LALLLFGFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 273 RFGMISWLPIYlLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSESLLMV 352
Cdd:pfam07690 216 FFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490203636 353 TVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGT 403
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL-GGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-399 |
6.19e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.00 E-value: 6.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 25 RYRMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 105 AIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGteh 184
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 185 WQSASYIVPACVAVVFAISVLVLgkgspreeglpsleemmPEEKVVLKTKHNQQAPEnmsafqifctyVLRNKNAWYVSF 264
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL-----------------PESRPAARARLRGSLRE-----------LLRRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 265 VDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkgRRMPLAMICMALIFICLIGYW 344
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---GRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490203636 345 KSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGA 399
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-435 |
1.16e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 110.74 E-value: 1.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVRNNFtlstPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17325 2 SLALFLDMLGYGIIIPIL----PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehwQSASY 190
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG----YRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 191 IVpaCVAVVFAISVLVLGkgspreeglpsleeMMPEEKVVLKTKHNQQAPENMSAFQIfctyvLRNKNAWYVSFVDVFVY 270
Cdd:cd17325 154 LV--CAALALLALVLALL--------------LLPEPRPPPNKRAVSAARLRSGLRLL-----LRDRRLLALFLAIFVLA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 271 MVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLIGYWKSESLL 350
Cdd:cd17325 213 FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI--GRK-PLILIGLLLSAVALLLLPLATSFW 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 351 MVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCI 430
Cdd:cd17325 290 LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPFLAAAALLLLAA 368
|
....*
gi 490203636 431 LFCYL 435
Cdd:cd17325 369 VLFLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-424 |
3.99e-24 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 103.47 E-value: 3.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 35 FLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFS 114
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 115 TAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVApivgAAFAILGTEHWQSASYIVPA 194
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAA----ALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 195 CVAVVFAISVLVLgkgsPREEGLPSLEEMMPEEKVVLKTKhnqqapenmsafqifctyVLRNKNAWYVSFVDVFVYMVRF 274
Cdd:cd17475 158 LVSILAAVLFWLF----YREPPAASAATESASTLLRSLKE------------------VLRNRDVWLIAIAGALLVAPQF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 275 GMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMP----LAMICMALIFICLIGYWKSESLL 350
Cdd:cd17475 216 ALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPvlviTAAIAAAALLVLSLLSPGTPLWL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490203636 351 MVTVFAAI-VGCLIYVPQFLAsvQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKM-GWHGGFYLLMG 424
Cdd:cd17475 296 LVLLLILLgLFAIGWNGLYLT--LVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDAThSYAPAWLALAL 368
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-438 |
9.25e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 99.54 E-value: 9.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 25 RYRMQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 105 AIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRV---GAFWNIshnvgGGIVAPIVGAAFAILG 181
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnllHAFFSL-----GALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 182 TEHWQSASYIVpacVAVVFAISVLVLGKGSpreeglpsleemMPEekvvLKTKHNQQAPENMSAFQIFctyvlRNKNAWY 261
Cdd:COG0738 159 LSLSWHLPYLI---LAVLLLLLALLFLRSK------------LPE----IEEEEEEAAGSAASLKSLL-----KNPRLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 262 VSFVdVFVYM-VRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFICL 340
Cdd:COG0738 215 GGLA-IFLYVgAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLAAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 341 IGYWKSESLLMVTVFAAIVGCLIYVPQFLASvqTMEIVPSFAvGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFY 420
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSL--ALDGLGKRT-AAAVSAVLIMGIV-GGAIGPPLIGFLADAFGLRAAFL 368
|
410
....*....|....*...
gi 490203636 421 LLMGGIVCCILFCYLSHR 438
Cdd:COG0738 369 VPLVCYLLILLLALALKR 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
53-442 |
3.77e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 98.02 E-value: 3.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:COG2807 42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRReRGRVGAFWNISHNVGGGIVApivGAAFAILGTEHWQSAsYIVPACVAVVFAISVLVLGKGSP 212
Cdd:COG2807 122 VGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAA---GLTVPLAAALGWRGA-LAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 213 REEGLPSLEEMMPEekvvlktkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTvKHFSK 292
Cdd:COG2807 197 AAAAAAPAAASLRS--------------------------LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIGYW--KSESLLMVTVFAAIVGCLIYVpqfLA 370
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLlaPGSLPWLWAVLLGLGQGGLFP---LA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490203636 371 SVQTMEIVPSFA-VGSAVGLRGFMSYIfGASLGTSLFGVMVDKMG-WHGGFYLLMGGIVCCILFCYLSHRGALE 442
Cdd:COG2807 325 LTLIGLRARTPAeAAALSGMAQSVGYL-LAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-421 |
7.25e-19 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 88.06 E-value: 7.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIvAPIVGAAFAILgTEHWQSAsY 190
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGL-GYVVGGLVAQA-TGGWRWA-F 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 191 IVPACVAVVFAISVLVLGKGSPREEglpsleemmpEEKVVLKTKHNQQAPENMSafqifctYVLRNKNAWYVSFVDVFVY 270
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVREPPRGA----------AEGGVMAKSTATSFLADLK-------ALAKNPSFILSTLGFTAVS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 271 MVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPS----TLLAGWLSDKLFKGRRMPLAMIC-----MALIFICLI 341
Cdd:cd17328 221 FVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKTPRADPLVCavgllAAAPFLFLA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 342 GYWKSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGGFYL 421
Cdd:cd17328 301 LVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDSPL 380
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-435 |
4.04e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 4.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRRERGRVGAFWnISHNVGGGIVAPIVGAAFAILGteHWQSASYIVPACVAVVFAISVLVLGKGSP 212
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLGQLL--GWRAAFLAIAVLALLAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 213 REEGLPSLEEMMPEekvvlktkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd17324 180 KKPGSLGLLSSLLL--------------------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFICLIGYWKSESLLMVTVFaaIVGCLIYVPQFLASV 372
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADR-GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV--LWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490203636 373 QTMEIVPSfAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFYlLMGGIVCCILFCYL 435
Cdd:cd17324 311 RVLRLAPE-ARGLASSLYLAAYNL-GGALGAALGGLVLDHGGWAGVGW-VGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-435 |
5.52e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.18 E-value: 5.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVrnnftLST-PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17489 2 LLANFFFFLSFYLL-----LPVlPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGFSTAFWIFAALVVLNGLFQGMgVGPSFITIANWF-PRRERGRVGAFWNISHNVgGGIVAPIVGAAFailgtehWQSA 188
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGA-FTTAAATLVADIiPPSRRGEGIGYYGLATTL-AMALGPALGLFL-------YQHL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 189 SYIVPACVAVVFAISVLVLGKGspreeglpsleemMPEEKVVLKTKHNQQAPENMsafqifctyVLRNKNAWYVSFVDVF 268
Cdd:cd17489 148 GFAVLFIVAAVLALLALLLVFL-------------VKDPPPVAAEEAEAGTRAFR---------RLVEKKVLPPALILFL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 269 VYMVRFGMISWLPIYlltvkhFSKEQMSVAFLFFEWAAIPSTL---LAGWLSDKlfKGRRMpLAMICMALIFICLIGYWK 345
Cdd:cd17489 206 ASIAYGAISTFLPLY------AAERGISNAGLFFTVYAIALLLsrpFSGKLSDR--KGPKT-VIIPGLLLLALGLLLLSF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 346 SESLLMVTVFAAI--VGCLIYVPQFLAsvQTMEIVPSFAVGSAVGLRgFMSYIFGASLGTSLFGVMVDKMGWhGGFYLLM 423
Cdd:cd17489 277 AGSPWMLLLAAVLygLGFGLLFPALQA--LAVDLVPPHRRGAANGTF-FIFFDLGIGLGGLLLGLVAELFGY-RAMFLLA 352
|
410
....*....|..
gi 490203636 424 GGIVCCILFCYL 435
Cdd:cd17489 353 AVVVLLALVLYI 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-435 |
5.98e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.15 E-value: 5.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRRERGRVGAFwNISHNVGGGIVAPIVGaafAILGTEHWQSASYIVPACVAVVFAisvlvlgkgsp 212
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGL-YEAALGLGIAVGPLLG---GLLAAISWRYPFFLLAALIPVAFL----------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 213 reeglpsleemmpeekVVLKTKHNQQAPENMSAFQIFCTYVLRNKNAW-YVSFVDVFVYM-VRFGMISWLPIYLLTVKHF 290
Cdd:cd17474 168 ----------------AILFLLPEPKEKAKSSSATKLRDLKKALRGRGlLTFLVSAFLYFfLYFAFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 291 SKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRR-MPLAMICMALIFIcLIGYWksESLLMVTVFAAIVGCLIYVpqFL 369
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRiLVIGLLLYALSLL-LLGFV--PSLALLLIAIVLFGLGLGL--NL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490203636 370 ASVQT--MEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYL 435
Cdd:cd17474 307 PLLTTlvTELAPEEERGTASSLYNFVRFL-GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
53-414 |
2.21e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 77.21 E-value: 2.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLfqg 132
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI--- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 mGVG---PSFITIANWFPRRERGRVGAFWNISHNVGGGIvAPIVGAAFAilgTEHWQSASYIVPACVAVVFAISVLVLGK 209
Cdd:cd17478 97 -GSAafhPEGARLASQAAGGRRGLAMSIFSVGGNLGFAL-GPLIAAALV---ALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 210 GSPREeglpsleemmpeekvvlkTKHNQQAPENMSAFQIFctyvlrNKNAWYVSFVDVFVYMVRFGMISWLPIYlLTVKH 289
Cdd:cd17478 172 LKKPE------------------AKKAAAKSSARSTLKGV------WRALLLLLIIVFLRSWVLSSLTTFLPFY-LVQRG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 290 FSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLIGYWKSESLLMVtVFAAIVGCLIYVPQFL 369
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF--GRR-RVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFASFPV 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490203636 370 ASVQTMEIVPSFaVGSAVGLrgFMSYIFG-ASLGTSLFGVMVDKMG 414
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGL--MMGLSFGlGGIGAPVLGALADAFG 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
31-431 |
1.96e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 74.57 E-value: 1.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAyGISKGVMS-SLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17329 5 LIGSFLNRLGFFMV---WPFMAIYLHQQLGLSASIVGLVLALSAVA-GIVASLIGgRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIvAPIVGAAFAILGtehwQSAS 189
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGLLLLYS----FRLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 190 YIVPACVAVVFAISVLVLgkgsPREEGLPSLEEMMPEEKVVLKTkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFV 269
Cdd:cd17329 156 FLAAAVLFLLAALVLLFL----LPETRPKRRAAEKTEILRGYKI-------------------VLRDRAFLLFLLASFLI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 270 YMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFfewAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSESL 349
Cdd:cd17329 213 SLIYFQLESTLPVYVVEILGLGESLLGLLLAL---NALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 350 LMVTVFAAI--VGCLIYVPqfLASVQTMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKmgwHGGFYLLMGGIV 427
Cdd:cd17329 290 AVLILAMIVltLGEMLVFP--AVQTLVAALAPPDKRGSYMGFYA-LAWGLGRAIGPLVGGLLLDL---LGPGLPWLILAA 363
|
....
gi 490203636 428 CCIL 431
Cdd:cd17329 364 LGLI 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-431 |
3.12e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 73.79 E-value: 3.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVRNNFTLSTPYLKE--QLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVN 108
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 109 VGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEH-WQs 187
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgWR- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 188 asyivpacvaVVFAISvlvlgkgspreeGLPSLeemmpeekvvlktkhnqqapenmsafqifCTYVLRnKNAWYVSFVDV 267
Cdd:cd17316 160 ----------ILFLIG------------ALPAL-----------------------------LALLLR-RRTLLLILLWF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKgRRMPLAMICMALIFICLIGYWKSE 347
Cdd:cd17316 188 FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILSGILALPLFYLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 348 SLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIV 427
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....
gi 490203636 428 CCIL 431
Cdd:cd17316 347 VALI 350
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
53-435 |
3.86e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 73.76 E-value: 3.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAafAILGTEHWQSASYIVPACVAVVFAISVLVLGKGSP 212
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAI-APALAPLLGG--LLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 213 REEGLPSLEEMmpeekvvlktkhnqqapenmsaFQIFcTYVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd17320 180 EEKRKPLLSSL----------------------LRAY-KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSESL----LMVTVFAAIVGCLIYVPQF 368
Cdd:cd17320 237 AQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLslwpLVAPLFLIFFGFGLIFPNA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 369 LAsvQTMEIVPSFAvGSAVGLRGFMSYIFGAsLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYL 435
Cdd:cd17320 317 TS--LALEPFPHVA-GTASALLGFLQFLIGA-LAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-213 |
5.69e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.98 E-value: 5.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVRNNFTL-STPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADK--ASPKVFMACGLVLCAI 106
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 107 VNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTehwq 186
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY---- 336
|
170 180
....*....|....*....|....*..
gi 490203636 187 SASYIVPACVAVVFAISVLVLGKGSPR 213
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-207 |
1.94e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.45 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17325 204 LFLAIFVLAFAFGAL---EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTehwqSAS 189
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF----ATP 356
|
170
....*....|....*...
gi 490203636 190 YIVPACVAVVFAISVLVL 207
Cdd:cd17325 357 FLAAAALLLLAAVLFLLL 374
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
62-431 |
2.76e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 71.15 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 62 SATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIF-AALVVLNGLFQGMGVGPSFI 140
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLyLLWGLLGGGGAGTLAAVAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 141 TIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehWQSAsYIVPACVAVVFAISVLVLGKGSPREEGLPSl 220
Cdd:cd17355 116 TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG---WRTA-LLVLALLALLVLVPVLLLLRRRPADLALRA- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 221 eemmpeekvvlkTKHNQQAPENMSAFQIFctyvlRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTvKHFSKEQMSVAFL 300
Cdd:cd17355 191 ------------YDDASPASPGSTLKEAL-----RSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 301 FFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIgyWKSESLLMVTVFAAIVGCLIYVPQFLASVQTMEIVPS 380
Cdd:cd17355 253 LIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLL--LLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGA 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490203636 381 FAVGSAVGLrGFMSYIFGASLGTSLFGVMVDkmgwHGGFYLLM--GGIVCCIL 431
Cdd:cd17355 331 RSYGTLFGL-VFAPHQLGSALGPWLGGLLYD----RTGSYTAAwaLAVALGLI 378
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-432 |
4.05e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 70.28 E-value: 4.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 57 EQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVvlngLFQGMGVG 136
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR----FVMGIGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 137 PSFITIANWF----PRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGtehwqsasYIVPACVAVVFAISVLVLGkgsp 212
Cdd:cd17477 100 GLFVVSESWLnalaTNENRGRVLGLYSTV-LGLGFALGPLLLALVGTAG--------ALPFLIAAVLLLLALVPLL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 213 reeglpsleemmpeekVVLKTKHNQQAPENMSAFQIFctyvlrnKNAWyVSFVDVFVY-MVRFGMISWLPIYLLTVkHFS 291
Cdd:cd17477 167 ----------------LTRRAAPEIEEAESISLRRLL-------RIAP-LALLGAFVAgFLEGAFYSLLPLYGLRL-GLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 292 KEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIGYWKSESLLMVTVFAAIVGCLIYVPQFLAS 371
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRF--DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLAL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490203636 372 VQTMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILF 432
Cdd:cd17477 300 ALAGDRLPGDELVAANAALL-LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
30-432 |
7.13e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 69.97 E-value: 7.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIvrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17341 4 SWLSFFLGFMVWFL----FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGFSTA-FWIFAALvvlnGLFQGMGvGPSFIT----IANWFPRRERGRVGAFWNISHNVGGGI---VAPIVGAAFAILG 181
Cdd:cd17341 80 ALALAVSsYWGLLVL----GFLLGFA-GANFASgqpwASFWFPKEKIGGAAGGIAGAGNMGVAVsqlLAPLIAGAIVFDG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 182 TEHWQSASYIVPACVAVVFAISVLVLGKGSPreeglpsleemmpeekvvlktKHNQQAPENMSAFQifctYVLRNKNAWY 261
Cdd:cd17341 155 GFVGWRNAFFVPGILLAIAAVLVLLFGDDLP---------------------TGKASALEFLKVQL----AVLKNYRTWI 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 262 VSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFICLI 341
Cdd:cd17341 210 LSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR-FGGRRRLWWLFIVMTIGAALL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 342 GYWKSESLLMVTVFAAIVGCLIYVPQFlASVQTMEIVPSF---AVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGG 418
Cdd:cd17341 289 SLSLPTSGTNLVLFLALFVALGLGAGA-GNGSVFRMVPFIfrrELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGA 367
|
410
....*....|....
gi 490203636 419 FYLLMGGIVCCILF 432
Cdd:cd17341 368 FSLFGVLAVACTLL 381
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-410 |
1.09e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.12 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVrnnfTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17321 2 LLAVFLAALDVTIV----NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAafAILGTEHWQSASY 190
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAV-VGIGAALGPLLGG--LLLELFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 191 I-VPACVAVVFAISVLVLGkgspreeglpsleemmpeekvvlktkhnqqapenmsafqifctyvlrnknawyvSFVDVFV 269
Cdd:cd17321 155 InVPIGLVALLLARTFSGA------------------------------------------------------VLAAFLL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 270 YMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSESL 349
Cdd:cd17321 181 GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSV 260
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490203636 350 LMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMV 410
Cdd:cd17321 261 WLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL-GGALGVALLGALL 320
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
52-418 |
2.00e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.78 E-value: 2.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 52 TPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPK-----VFMACGLVLCAIVNV------GLGFSTAFWIF 120
Cdd:COG2211 34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVllftapDLSPTGKLIYA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 121 AALVVLNGLFQGMGVGPSFITIANWFP-RRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEHWQSASYIVpACVAVV 199
Cdd:COG2211 114 LVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTA-LIFAVL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 200 FAISVLVLGKGSPReeglpsleemmpeekvvlktkHNQQAPENMSAFQIFCTyVLRNKNAWYVSFVDVFVYMVRFGMISW 279
Cdd:COG2211 193 GLLAFLLTFFGTKE---------------------RPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 280 LPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLIGYW--KSESLLMVTVFAA 357
Cdd:COG2211 251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKK-KAFIIGLLLAALGLLLLFflGPGNLWLLLVLAA 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490203636 358 IVGCLIYVPQFLASVQTMEIVPS-------FAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGG 418
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKL-GQALAGALAGLLLALFGYVAG 394
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
66-433 |
3.18e-12 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 68.11 E-value: 3.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 66 IGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVN--VGLGFST---AFWIFAALVVLNGLFQGMGvGPSFI 140
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTalFGLGYYWnihSLWYFVVVQILAGLFQSTG-WPSVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 141 T-IANWFPRRERGRVGAFWNiSHNVGGGIVAPIVGAAFAILGtehWqSASYIVPACVAVVFAISVLVLGKGSPreeglPS 219
Cdd:cd17344 143 AcVGNWFGKGKRGLIMGIWN-SHTSVGNILGSLIAGIFVSSA---W-GLSFIVPGIIIAAMGVLVFLFLVEHP-----PG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 220 LEEMmpeekvvlktkhnqqapenmsafqifctyvlrnknawyvSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAF 299
Cdd:cd17344 213 VIEF---------------------------------------SLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 300 LFFEWAAIPSTLLAGWLSDKlFKGRrmplAMICMALIFIC-----LIGYWKSESLLMVTVFAAIVGCLIYVPQFL----- 369
Cdd:cd17344 254 TLFDVGGIVGGILAGYISDY-TGGR----ATTCAAMLILAapmlfIYNYFGQVSMTTNIVLLIVCGLLVNGPYALittav 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 370 -ASVQTMEIVPsfavGSAVGLRGFMSYI-----FGASLGTSLFGVMVDKmGWHGGFYLLMGGIVCCILFC 433
Cdd:cd17344 329 sADLGTHKSLK----GNARALATVTAIIdgtgsIGAALGPLLAGLISSR-GWNNVFYMLIAADVCAGLLL 393
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
30-204 |
1.68e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.83 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVrnnfTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:COG0477 19 LALGTFLEGLDFTIV----NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGTEHWQSAS 189
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170
....*....|....*
gi 490203636 190 YIVPACVAVVFAISV 204
Cdd:COG0477 174 NAPLGLLALVLRLRL 188
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
32-362 |
1.03e-10 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 63.09 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 32 LSVFLGYLAYYIVRnnfTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGL 111
Cdd:TIGR00886 8 FGFFLSFLVWFAFS---PLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 112 GFSTA-FWIFAALVVLNGlFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEH------ 184
Cdd:TIGR00886 85 GLAVQsYSVLLLIRLFIG-IAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGgqpahl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 185 -WQSASYIVPACVAVVFAISVLVlgkgspreeglpsleemmpeekVVLKTKHNQQAPENMSAFQIFctYVLRNKNAWYVS 263
Cdd:TIGR00886 164 aWGWAFVIVPAGILLLPALLIFF----------------------VGADTPPGKPATGKLSFKEAL--KVFGNRHTWILA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 264 FVdvfvYMVRFG----MISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFkGRRMPLAMICMALIFI- 338
Cdd:TIGR00886 220 LL----YSVTFGsflgVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLG-GARKLLMNFLGVAMGAf 294
|
330 340
....*....|....*....|....
gi 490203636 339 CLIGYWKSESLLMVTVFAAIVGCL 362
Cdd:TIGR00886 295 LVVLGLVSDGSLAAFIVLFVALFF 318
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
1-207 |
3.70e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 1 MLSLLKKGPSANKVPAEKIQAT----YGRYRMQ--ALLSVFLGYLAYYIVRNNFTLSTPYL-KEQLDLSATQIGLLSSCM 73
Cdd:cd06173 174 LLLFIRRPPPAAPGESSSLLLRdlreGLRYLRRspLLRLLLLALALFALLGGALTVLLPLLaKEVLGGGAAGYGLLLAAF 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 74 LIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGR 153
Cdd:cd06173 254 GVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 490203636 154 VGAFWNISHNVGGGIVAPIVGAAFAILGTehwqSASYIVPACVAVVFAISVLVL 207
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGL----SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-203 |
5.13e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.03 E-value: 5.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17321 173 AVLAAFLLGAALGGL---LFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGF---STAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEHWQ 186
Cdd:cd17321 250 LLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329
|
170
....*....|....*..
gi 490203636 187 SASYIVPACVAVVFAIS 203
Cdd:cd17321 330 DSGVAALLSAAAAAFAA 346
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
48-433 |
7.22e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 60.40 E-value: 7.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLN 127
Cdd:cd06180 18 YTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 128 GLFQGMGVGPSFITIANWFPRRERGRVGAFwnISHNVGGGIVAPIVGAAFAILGTEHWQSASYIVPACVAVVFAISVLVL 207
Cdd:cd06180 98 GAASAFVFVFGSNLVLHHATAAGRGHLIGL--LFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 208 GKGSPREEGLPSLEemmpeekvvlktkhnQQAPENMSAFQIFCTYVLRNknawyvsfvdvFVYMVrfgMISWLPIYLLtV 287
Cdd:cd06180 176 RRGPSAPTEASAAE---------------SAPGLNRPLWRLALAYGLFG-----------FGYII---TATFLPLIAR-E 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 288 KHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIgywkseSLLMVTVFAAIVGCLIYVPQ 367
Cdd:cd06180 226 TGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRW--GTRRALAANLLVQAVGVLL------PLLSPGPAGLVLSAVLFGGT 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490203636 368 FLASVQ-TMEIVPSFAVGSAVGLRGFM--SYIFGASLGTSLFGVMVDKmgwHGGF----YLLMGGIVCCILFC 433
Cdd:cd06180 298 FMAITAlVMALARELAPPAAPRALALMtaSFGVGQILGPLLAGWLADA---TGGFapalILAAAALVVAALLA 367
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
53-431 |
1.40e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.52 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17365 23 PALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 mGVGPSFITI-ANWFPRRERGRVGAFWNISHNVGGGIVAPIvgaAFAILGTEHWQSASYI--VPACVAVVFAISVLVLgk 209
Cdd:cd17365 103 -AAMPNAITLvSEYAPARRRSLAVTLMFCGYPLGAALGGFL---AAALIPAFGWRSVFLLggVPPLILLPLLRGTLLL-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 210 gspreeglpsleemmpeekvvlktkhnqqapenmsafqifctyvlrnknaWYVSFVDVFVYmvrFGMISWLPiYLLTVKH 289
Cdd:cd17365 177 --------------------------------------------------WVTFFMGLLLV---YLLNSWLP-KLMVEAG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 290 FSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFICLIGYwKSESLLMVTVFAAIVGCLIYVPQFL 369
Cdd:cd17365 203 YSLSQALTITLLLNIGGVIGSLLLGWLADR-FGPKRVLALFFALGAVSLALLGV-SPASLVLLYVLVFLAGACVNGAQVG 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490203636 370 ASVQTMEIVPSFAVGSAVGLRGFMSYiFGASLGTSLFGVMVDkMGW--HGGFYLLMGGIVCCIL 431
Cdd:cd17365 281 LYALAARFYPTEVRATGVGWALGVGR-LGAILGPLLGGLLLA-AGLgpESVFLALAIPAALGAL 342
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-410 |
1.65e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.68 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 25 RYRMQALLSVFLGYL--AYYIVRNNFTLstPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLV 102
Cdd:TIGR00895 13 RYQWRAIILSFLIMLmdGYDLAAMGFAA--PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 103 LCAIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVG---GGIVAPIVGAAFAi 179
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaavGGFLAGWLIPVFG- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 180 lgtehWQSASYI---VPACVAVVFAISV------LVLGKG-SPREEGLPSLEEMMPEEKVVLKTKHNQQAPENMSAFQIF 249
Cdd:TIGR00895 170 -----WRSLFYVggiAPLLLLLLLMRFLpesidfLVSKRPeTVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 250 C-TYVLRNKNAWYVSFVDVFVYmvrFGMISWLPiYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPL 328
Cdd:TIGR00895 245 QgKTARITVLLWLLYFMLLVGV---YFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL--GPRVTA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 329 AMICMALIFICLIGYWKSESLLMVTvFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVglrGFMSYI--FGASLGTSLF 406
Cdd:TIGR00895 319 LLLLLGAVFAVLVGSTLFSPTLLLL-LGAIAGFFVNGGQSGLYALMALFYPTAIRATGV---GWAIGIgrLGAIIGPILA 394
|
....
gi 490203636 407 GVMV 410
Cdd:TIGR00895 395 GYLL 398
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
262-435 |
2.57e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 2.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 262 VSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLI 341
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 342 GYWKSESLLMVTVFAAIVGCLIYVpqfLASVQTMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKMGWHGGFYL 421
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFP---AALALIADWFPPEERGRALGLVS-AGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|....
gi 490203636 422 LMGGIVCCILFCYL 435
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
48-432 |
4.24e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.08 E-value: 4.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALvvln 127
Cdd:cd17371 18 LGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL---- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 128 GLFQGMGVGPSF----ITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEH-WQSASY--IVPACVAVVF 200
Cdd:cd17371 94 RALAGLGFGGEWaagaALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIaWRVLFLlgALPALLVLFI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 201 AISVlvlgkgspreeglpsleemmPEEKVVLKTKHNQQAPENMSAFQIFCTYVLRNKNAwYVSFVDVFVYMVRFGMISWL 280
Cdd:cd17371 174 RRFV--------------------KEPPQWQAARAARRHFADRPSLRELFSPPLLRTTL-LASLLATGALGGYYGITTWL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 281 PIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMI-CMALIFICLIGYWKSESLLMVTVFAAIV 359
Cdd:cd17371 233 PSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI--GRRNNFALFaLGSAISILLYFFLPLSPTLILILGFPLG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490203636 360 GCLIYVPQFLASVQTmEIVPSFAVGSAVGLrgfmSYIFG---ASLGTSLFGVMVDKMGWHGGFyLLMGGIVCCILF 432
Cdd:cd17371 311 FFASGPFSGMGAYLT-ELFPTAVRATAQGF----CYNVGriiGALFPFLVGFLATSGSLGTAI-AVFAAVYYIAGL 380
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
66-432 |
4.87e-09 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 58.09 E-value: 4.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 66 IGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAF------WIFAALVVLNGLFQGMGvGPSF 139
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWlhfynkYLYCILWVLNGLLQSTG-WPCV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 140 ITI-ANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGTEHwqsaSYIVPAcvAVVFAISVLVLGKGSPREEGLp 218
Cdd:cd17342 144 VAImGNWFGKSSRGFVLGLWSACASV-GNIIGALLASSVLDYGYEY----AFLVTS--SLLFAGAIVVFFGLLSSPPGV- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 219 sleemmpeekvvlktkhnqqapenmsafqIFCtyvlrnknawyvSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVA 298
Cdd:cd17342 216 -----------------------------IPY------------SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 299 FLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIGYWKSES-------LLMVTVF----------AAIVGC 361
Cdd:cd17342 255 SIWYDVGGIIGGIVAGYISDRM--GSRSPVVVVMLLLAIPSLFVYSHSPSdkvlnafVMTITGFfiggpanlisSAISAD 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490203636 362 LIYVPQFLASVQTMEIVPSFAVGSAVglrgfmsyiFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILF 432
Cdd:cd17342 333 LGRQPQLRGSSEALATVTGIIDGTGS---------IGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVC 394
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-207 |
5.81e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.58 E-value: 5.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVRNNFTLSTP-YLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADK----ASPKVFMACGLVLCA 105
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPtYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrgARRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 106 IVnVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTehw 185
Cdd:cd17319 261 GL-LLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGS--- 336
|
170 180
....*....|....*....|..
gi 490203636 186 QSASYIVPACVAVVFAISVLVL 207
Cdd:cd17319 337 YTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
34-344 |
1.17e-08 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 56.87 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 34 VFLGYLAYYIVRNNFTLSTPY-LKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLG 112
Cdd:cd17327 10 LCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 113 FSTAFWIFAALVVLNGLFQGmGVGPSFI-TIANWFPRRERGRVGAFWNISHNVG---GGIVAPIVGAAFAILGTEHWQSA 188
Cdd:cd17327 90 AVKNFGGLIALRFFLGLFES-GVFPGFIlYLGMWYKREEQAKRIAFFYAAAGLGsifGGLLAYGVFKILGVGGLAGWRWL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 189 sYIVPACVAVVFAISVLVLGKGSPREEGLPSLEEmmpEEKVVLKTKHNQQAPENMSAFQIFCTYVLRNKNAWYVSFVDVF 268
Cdd:cd17327 169 -FIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEE---KELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFC 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 269 VYMVRFGMISWLPIYLLTVKHFSKE--QMSVAFLFFEWAAIpstLLAGWLSDKLfkGRRMPLA--MICMALIFICLIGYW 344
Cdd:cd17327 245 SQITNNGISNFLPLILKSLGFYSLQtnLLSVPIGALGAVSL---LIAALLSDRF--KKRGLFAifACVLALVGSIILLAA 319
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
30-189 |
1.61e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.43 E-value: 1.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17503 183 GLLLSFLLGLGLFGA---MFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 110 GLGFSTAFWIFAALVVLNgLFQGMGVGPSFITIANWF----PRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEHW 185
Cdd:cd17503 260 LLAFLTPDTSLWLIILPL-FIRGLGMGLVFMPLNTLAlnslPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHH 338
|
....
gi 490203636 186 QSAS 189
Cdd:cd17503 339 SRLS 342
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
28-209 |
1.89e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 28 MQALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:COG2211 231 LLLLLAYLLFFLALALV---AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 108 NVGLGFSTA--FWIFAALVVLNGLFQGMGVGPSFITIAN-------WFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFA 178
Cdd:COG2211 308 LLLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190
....*....|....*....|....*....|....*....
gi 490203636 179 ILG--TEHWQSASYIVP------ACVAVVFAISVLVLGK 209
Cdd:COG2211 388 LFGyvAGAAQSPSALTGirllffLLPAVLLLLAALLLLF 426
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
31-208 |
3.92e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 3.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17473 203 YFLAFLAMLLFYVI---PIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNvGGGIVAPIVGAAFAILGTEHwqSASY 190
Cdd:cd17473 280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFF-LGQFLSPLVLGPLVNLTGGL--SGAF 356
|
170
....*....|....*...
gi 490203636 191 IVPACVAVVFAISVLVLG 208
Cdd:cd17473 357 LILGVLALVLAIVLLLLR 374
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
48-431 |
1.56e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 53.35 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLN 127
Cdd:cd17323 18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 128 GLF--QGMGVGPSfiTIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAafAILGTEHWQSASYIVPACVAVVFAISVL 205
Cdd:cd17323 98 GFFgsSPLAIGAG--TIADLFTPEERGKAMGVYSLGPLL-GPALGPIIGG--FITQSLGWRWIFWFLAIISGFCLILIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 206 VLgkgspreeglpsleemmPEekvvlktkhnqqapenmsafqIFCTyvlrnknAWYVSFVDVFVYMVRFGmiswLPIYLL 285
Cdd:cd17323 173 FL-----------------PI---------------------VLLL-------GLYVGLVYAILYLFLTA----FPYVFG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 286 TVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGR------------RMPLAMICMALIFICLIGY-W---KSESL 349
Cdd:cd17323 204 EVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkkknggkpepeaRLPPAFIGAFLFPIGLFIFgWtiyPHIHW 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 350 LMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVgSAVGLRGFMSYIFGAslGTSLFGV-MVDKMGWHGGFYLLmgGIVC 428
Cdd:cd17323 284 IVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAA-SALAANTLVRSIFAA--IFPLFAQpMFNNLGVGWAFTLL--AFIS 358
|
...
gi 490203636 429 CIL 431
Cdd:cd17323 359 LAM 361
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-436 |
2.05e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 58 QLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAF-----WIFAALVVLNGLFQG 132
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLgslslWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGTEhwqsasyIVPACVAVVFAISVLVLGkgsp 212
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG-------GAFAINALSFLLSALLLL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 213 reeGLPSLEEMMPEEKvvlktkhnqqAPENMSAFQIFCTYVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd06173 177 ---FIRRPPPAAPGES----------SSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFIcLIGYWKSESLLMVTVFAAIVGCLIYVPQFLASV 372
Cdd:cd06173 244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL-VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490203636 373 QtmEIVPSFAVGSAVGLRGFMSYIFgASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYLS 436
Cdd:cd06173 323 Q--LRVPDELRGRVFSVYNALNSGA-MPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-205 |
3.49e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.04 E-value: 3.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVRNNF-TLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASP-KVFMACGLVLCAIV 107
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFsTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGrKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 108 NVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGaafAILGTEHWQS 187
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG---FLLAATFGLT 360
|
170
....*....|....*...
gi 490203636 188 ASYIVPACVAVVFAISVL 205
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-205 |
5.84e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.45 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 21 ATYGRYRM-QALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMAC 99
Cdd:cd17316 172 ALLLRRRTlLLILLWFFISFGYYGL---TTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 100 GLVLCAIVNVGLGF--STAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGR-VGAFWNIShNVGGGIVAPIVGaa 176
Cdd:cd17316 249 GLILSGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATgVGLSYNLG-RLGGGGAPPLIA-- 325
|
170 180
....*....|....*....|....*....
gi 490203636 177 fAILGTEHWQSASYIVPACVAVVFAISVL 205
Cdd:cd17316 326 -LLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
289-435 |
2.33e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 289 HFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLIGYWKSESLLMVTVFAAIVGCLIYVPQF 368
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRR-RVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 369 LASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYL 435
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-436 |
3.08e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.11 E-value: 3.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSAT--QIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:cd17330 1 LFLVVFLDALGFGIV---FPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 108 NVGLGFSTAFWIFAALVVLNGLFQGmGVGPSFITIANWFPRRER----GRVGAFWNIshnvgGGIVAPIVGAAFAilgte 183
Cdd:cd17330 78 YVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERakafGIISAAFGL-----GFILGPALGGFLS----- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 184 hwQSASYIVPACVAVVFAISVLVLGKgspreEGLPSLeemmpeekvvlktkhnqqapenmsafqifctyvlrnknaWYVS 263
Cdd:cd17330 147 --TPYGYALPFLVAAALALLNLVLVL-----FFLPPL---------------------------------------RRLL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 264 FVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGY 343
Cdd:cd17330 181 LVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPF 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 344 WKSESLLMVTVFAAIVGCLIYVPQFLASVQtmEIVPSFAVGSAVGLRGFM---SYIFGASLGTSLFGVmvdkmgWHGGFY 420
Cdd:cd17330 261 ASSVPLLVLAAAILAFGTGIVFPALSALLS--KSVPSKEQGKAQGIIQSLqslARIIGPLLAGPLYSF------LGPGVP 332
|
410
....*....|....*.
gi 490203636 421 LLMGGIVCCILFCYLS 436
Cdd:cd17330 333 FLLAAGLLLIALFLLS 348
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
55-432 |
3.33e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 55 LKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGlfqGMG 134
Cdd:cd17339 25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGTALAGA---GIA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 135 VG----PSFITiaNWFPRReRGRVGAFWNISHNVGGGIvAPIVGAAFAILGTEHWQSA--SYIVPACVAVVFAISVLVLG 208
Cdd:cd17339 102 VGnvllPSLIK--RDFPRR-VGLMTGLYTTSMNLGAAL-ASGLSVPLAQALGGGWRGAlaIWALPALLALLIWLPQLRRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 209 KGSPreeglpsleemmpeekvvlkTKHNQQAPENmsafqifctyVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLltVK 288
Cdd:cd17339 178 KRAA--------------------AAAAPLTKIS----------VWRSPLAWQVTLFMGLQSLLFYTLMAWLPTIL--ID 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 289 H-FSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfKGRRmPLAMICMALIFICLIG--YWKSESLLMVTVFAAIVG----- 360
Cdd:cd17339 226 AgLSAATAGWLLSLFQLVGIPASLLVPILATRL-KNQR-PIVVLLAVLFIIGVLGllFAPTALALLWAVLLGLGGgaafs 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 361 -CLIYVPQFLASVQTmeivpsfavgsAVGLRGFMS---YIFgASLGTSLFGVMVDKMG-WHGGFYLLMGGIVCCILF 432
Cdd:cd17339 304 lALTLISLRSSDPAE-----------AAALSGMAQsvgYLL-AALGPLLFGVLHDLTGsWTAPLVLLLALTVLQLVA 368
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
53-416 |
6.06e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 6.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17503 20 PTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRRERGRVGAFWNIshnvgGGIVAPIVGAAFAILGTEH--WQSASYI-VPACVAVVFAISVLVLGk 209
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGL-----VILLAPAIGPTLGGWLTDNlsWRWIFYInLPIGILALLLAPLLDLR- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 210 gspreeglpsleemmpeekvvlktkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKH 289
Cdd:cd17503 174 -------------------------------------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 290 FSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSESLLMVTVFAAIVGC---LIYVP 366
Cdd:cd17503 211 YSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLgmgLVFMP 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 490203636 367 qflASVQTMEIVPSFAVGSAVGLRGFMSyIFGASLGTSLFGVMVDKMGWH 416
Cdd:cd17503 291 ---LNTLALNSLPPEQIGDATALFNTIR-QLGGSIGTALLATLLTNRTQF 336
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
13-202 |
7.01e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 48.29 E-value: 7.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 13 KVPAEKIQATYGRYRMQALLSVFLGYLAYYIVrNNFTLStpYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKAS 92
Cdd:cd17369 216 RAPLVEVLRRHWRALLLAIGLRLAENVLFYLF-TTFALS--YATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 93 PKVFMACGLVLCAIVNV----GLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRER-GRVGAFWNISHNVGGG 167
Cdd:cd17369 293 RRPVYLAGALLAALFAFpffwLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRyTGASLGYQLGAILGGG 372
|
170 180 190
....*....|....*....|....*....|....*
gi 490203636 168 IvAPIVGAAFAILGTEHWQSASYIVPACVAVVFAI 202
Cdd:cd17369 373 F-APLIATALVAATGSWWPVALYLAALAVISLVAA 406
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-432 |
8.07e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.99 E-value: 8.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWifaALVVLN 127
Cdd:cd17353 22 WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLP---LLFLGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 128 GLFQGMGVGPSFITIAN----WFPRReRGRVGAFWNISHNVGGGIVAPIvgaAFAILGTEHWQSASYIVPACVAVVFAIS 203
Cdd:cd17353 99 GVLGGIGAGIGYITPVStavkWFPDK-RGLATGIVIAGFGLGSLIFSPL---IAYLINTVGVPTTFLILGIIFLIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 204 VLVLGkgspreeglpsleemMPEEKVVLKTKHNQQAPENMSAFQIFCTYVLRNKNAW--YVSFVdvFVYMVRFGMISWLP 281
Cdd:cd17353 175 AFLIR---------------DPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWllWLMFF--LNATAGLMLIGQAK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 282 IYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIGYWKSESLLMVTVFAAIV-- 359
Cdd:cd17353 238 PIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI--GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIgf 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490203636 360 ---GCLIYVPQFLASVqtmeivpsFAVGSAVGLRGFM--SYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILF 432
Cdd:cd17353 316 cygGGFALFPALTADF--------FGTKNAGTNYGLLytAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
83-436 |
1.09e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 83 VMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWifaaLVVLNGLFQGMGVG---PSFIT-IANWFPRRERGRVGAFW 158
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY----ALLASRALLGIGVAgimTLATAlIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 159 NISHNVGGGIVAPIVGAafaiLGTEHWQS--ASYIVPACVAVVFAISVlvlgkgspreeglpsleemmpEEKVVLKTKHN 236
Cdd:cd17473 130 SAAMSLGGVVFLLLGGA----LAEIGWRApfLVYLLALPVLILVLLFL---------------------PEPARKSKSAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 237 QQAPENMSAFqifctyvlRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWL 316
Cdd:cd17473 185 SPGAATAAAL--------PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 317 SDKLFKGRRMPLAMICMALIFIcLIGYWKSESLLMVTVFAAIVGCLIYVPqfLASVQTMEIVPSFAVGSAVGLRGfMSYI 396
Cdd:cd17473 257 KRRLGKRRLLAIGFALMALGFL-LLALASGLWVVLLGAILAGLGFGLLLP--TLNSWAMSLVPPELRGRAMGIVT-SAFF 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 490203636 397 FGASLGTSLFGVMVDKMGWHGGFYLLMGGI--VCCILFCYLS 436
Cdd:cd17473 333 LGQFLSPLVLGPLVNLTGGLSGAFLILGVLalVLAIVLLLLR 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
131-405 |
1.91e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 131 QGMGVGP----SFITIANWFPRRERGRVGAFWNISHNVGGgIVAPIVGAAFAILGTEHWqsasyivpacvavVFAISvlv 206
Cdd:cd17502 93 QGIGGGGlmslAFIIIADLVPPRERGKYQGYIGAVFGIAS-VAGPLIGGAFTDHLSWRW-------------CFYIN--- 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 207 lgkgspreegLPsleemmpeekvvlktkhnqqapenmsaFQIFCTYVLRNknAWYVSFVDVFVYMVRFGMISWLPIYLLT 286
Cdd:cd17502 156 ----------LP---------------------------IGGLALALLRT--ILLSSIFGFLFGGALFGLIYYLPLYFQL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 287 VKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRR-MPLAMICMALIFICLIGYWKSESLLMVTVFAAIVGCL--I 363
Cdd:cd17502 197 VLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPlIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGlgI 276
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 490203636 364 YVPQFLASVQtmEIVPSFAVGSAVGLRGFMSYIfGASLGTSL 405
Cdd:cd17502 277 GFQQPLVAVQ--NAVPPADVGVATATNTFFRSL-GGTLGVAI 315
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
254-435 |
2.77e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 254 LRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFK--GRRMPLAMI 331
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 332 CMALIFICLIGYWKSESLLMVTVFAAIVGCLIyvpqFLASVQTMEIVPSFAVG-----------SAVGLRGFMSYIfGAS 400
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGKLIYALVTYL----LLGLAYTLVNIPYSALGaeltpdyeertRLSSWRFAFAGL-GGL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 490203636 401 LGTSLFGVMVDKM------GWHGGFYLLMGGIVCCILFCYL 435
Cdd:COG2211 162 LASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFF 202
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
53-418 |
4.25e-05 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 45.70 E-value: 4.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADK--ASPKVFMACGLVlCAIVNVGLGFSTAFWIFAALVVLNGLF 130
Cdd:cd06177 22 GYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRffAAEKVLAVLHLI-GAAALFYAATVTDFSVFFWVMLLYSLC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 131 Q----GMGVGPSFITIANwfPRRERGRVGAFWNIshnvgGGIVApivGAAFAILGTE--HWQsasYIVPACVAVVFAISV 204
Cdd:cd06177 101 YmptlALTNSIAFSNLED--PVKDFPPIRVWGTI-----GWIAA---GWPVGFLGWEasNLQ---FYIAAGASLLLGLYS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 205 LVLGKGSPREEGLP-SLEEMMPEEKVVLKTKhnqqapENMSAFQIfCTYVLRNKNAWYVSFVDVFVYmvRFGMISWLPIY 283
Cdd:cd06177 168 LTLPHTPPKKAGKGvSKRSLLGLDAFVLLKN------PFFAVFFI-FSFLLGAPLQFYYTFANPFLN--DFGMIVKNPAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 284 LLTVKHFSKeqmsvaFLFFewAAIPSTLlagwlsDKLFKGRRMPLAMICMALIFICLIgyWKSESLLMVTVFAAIVGCLI 363
Cdd:cd06177 239 IMSLGQISE------ILFM--LAIPFFL------KRLGIKKVMLIGMLAWVLRFGLFA--YGDPSPGVWMLVLSIILHGV 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 364 YVPQFLASVQ--TMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGG 418
Cdd:cd06177 303 CYDFFFVTGYiyVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEG 359
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
37-435 |
5.47e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.34 E-value: 5.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 37 GYLAYYIVRNNFTLSTPYlkEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFST- 115
Cdd:pfam00083 21 AFLTLIDFFKNFGLSKSV--SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKg 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 116 --AFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGgIVAPIVGAAFAILGtehwQSASYIVP 193
Cdd:pfam00083 99 kwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGI-LLAYIFGLGLNKTS----NSDGWRIP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 194 ACVAVVFAISVLVLG---KGSPR--------EEGLPSLEEMMPEEKVVLKTKHNQQA-PENMSAFQIFCTYVLRNKNAWY 261
Cdd:pfam00083 174 LGLQLVPALLLIIGLlflPESPRwlvekgrlEEAREVLAKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 262 VSFVDVFVYMVRF--GM--ISWLPIYLLTVKHFSKEQMsVAFLFFEWAAIpSTLLAGWLSDKLfkGRRMPL------AMI 331
Cdd:pfam00083 254 RLLIGVMLQIFQQltGInaIFYYSTTIFENLGLSDSFL-VTIIVGVVNFV-FTFIAIFLVDRF--GRRPLLllgaagMAI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 332 CMALIFICLIGYWKSESllmVTVFAAIVGCLIYVPQFLASVQTM------EIVPSFAVGSAVGLRGFMSYIFGAsLGTSL 405
Cdd:pfam00083 330 CFVILGIVALLGVSKSD---WAGIVAIVFIALFIAFFAMGWGPVpwvivsELFPLSVRSKAMALATAANWLANF-LIGFL 405
|
410 420 430
....*....|....*....|....*....|
gi 490203636 406 FGVMVDKMGWHGGFYLLMGGIVCCILFCYL 435
Cdd:pfam00083 406 FPIITDAIGLGYTFFIFAGLLVLFIIFVFF 435
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
34-433 |
6.02e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 6.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 34 VFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGF 113
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 114 STAFWIFAALVVLNGLFQGM---GVGPSFITIANWFPRRERGRVGAFWNIshnvgGGIVAPIVGAAFaiLGTEHWQSASY 190
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGIldtGANTFVGALFEESSATRLNVLHGFFGL-----GALIGPLIATSL--LTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 191 IVPACVAVVFAIsVLVLGKGSPREEGLPSLEEMMPEEKVVLKTKHNQQApeNMSAFQIFCTYVlrnknawyvsfvdvfvy 270
Cdd:cd17333 154 LIIGLIYLLLAI-LILLTLFPELPSARNPQQSVGAFSASASRLLRNPSI--ILGALALFLYVG----------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 271 mVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIgywkseSLL 350
Cdd:cd17333 214 -AETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI--KPHTLLVLSGSGALLGLLI------LLL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 351 MVTVFAAIVGCLIY----VPQFLASVQTMEIVPSFAVGSAVGLrgfmsYIFGASLGTSLFGVMVDKMGWHGGFY--LLMG 424
Cdd:cd17333 285 APTLVVGLVATALLglfmAALFPTILSLGISNLPYAKGKGTSV-----LLAAGSIGGAIIPFIMGFIAEAVGIQtaMLLI 359
|
....*....
gi 490203636 425 GIVCCILFC 433
Cdd:cd17333 360 TILYAIIFV 368
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
264-438 |
6.46e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.92 E-value: 6.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 264 FVDVFVYMVRFGMISWLPiYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLA--MICMALIFIcli 341
Cdd:cd17475 3 LAQAAASLVAQGIPALAP-FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRF--GERRVLAvgLLLMGAAAL--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 342 gywkseSLLMVTVFAAIVGCLIYVPQFLASVQ------TMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKMGW 415
Cdd:cd17475 77 ------LMALVGSYPVLLVLLFLVGAGYGSVQpgggraIMRWFPPRERGLAMGIRQ-TGVPLGGALAAALLPPLALHYGW 149
|
170 180
....*....|....*....|...
gi 490203636 416 HGGFYLLMGGIVCCILFCYLSHR 438
Cdd:cd17475 150 RAAFVVAGLVSILAAVLFWLFYR 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-432 |
7.29e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 7.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 48 FTLSTPYLKEqLDLSATQIGLLSSCM-LIAYgISKGVMSSLADK-ASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVV 125
Cdd:cd17370 19 RSILPLFLVV-LGASAAAVGLIEGLAeALGS-LLRLFSGYLSDRtGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 126 LNGLFQGMGVGPSFITIANWFPRRERGRvgAF-WNISHNVGGGIVAPIVGAAFAILGTEHWQSASYI--VPACVAVVfai 202
Cdd:cd17370 97 LERLGKGIRTPPRDALLADATPPSGRGK--AFgLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLaaIPALLALL--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 203 svlvlgkgspreeglpsleemmpeekVVLKTKHNQQAPENMSAFQIFCTYVLRNKNAWYVSFVdVFVYMvrFGMISW-LP 281
Cdd:cd17370 172 --------------------------ILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLA-VALFA--LGNFSFaFL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 282 IYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSESLLMVTVFAAIvgc 361
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL--- 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 362 liyvpqFLASVQTME------IVPSFAVGSAVGLRGFMsYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILF 432
Cdd:cd17370 300 ------YMGAQESIEraavadLVPAELRGTAYGLFNTV-VGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
54-206 |
9.72e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.50 E-value: 9.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 54 YLKeQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKAS-PKVFMACGLVLCAIVNVGLGF-STAFWIFAALVVLNGLFQ 131
Cdd:cd17335 23 YLK-QLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFvAQIFWLLLLLVILGAFFS 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490203636 132 GMGVgPSFITIANWFPRRERGRVGA--FWNishNVGGGIVAPIVGAAFAILGTEHWQSASYIVpacVAVVFAISVLV 206
Cdd:cd17335 102 APVV-PLVDSITLQYLGEERERYGKqrLWG---SIGFGIAALLVGILIDRSSTYKNYTIAFYV---FAVLMLLALLL 171
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-435 |
1.02e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 52 TPYLKEqLDLSATQIGLlsscMLIAYGISK-------GVMSSLADKAspKVFMACGLVLCAIVNVGLGFSTAFWIFAALV 124
Cdd:cd17490 20 SPYAES-LGASLSMIGI----ILGAYGISQmllriplGILSDRIGKR--KLFIIIGLLFTVLASLIMILFPSPWGLLIAR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 125 VLNGLFQGMGVgpSF-ITIANWFPRRERGRVGAFWNISHNVGGgIVAPIVGAAFAilgtEHW-QSASYIVPACVAVV-FA 201
Cdd:cd17490 93 FLSGIAAATWV--SFtVLYASYFPPDEAAKAMGLINLVNNLGQ-LIAFLIGGLIA----EHFgMRAPFLLAALAGVLgFI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 202 ISVLVlgkgspREEglpsleemmpeekvvlKTKHNQQAPENMSAFQifctyVLRNKNAWYVSFVDVFVYMVRFGMI-SWL 280
Cdd:cd17490 166 LSLFI------KEE----------------RREKKPVLTELKELLS-----VLKDKKLLFFSLLAILQQMITFSTTfGFT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 281 PIYL--LTVKHFSKEQMSVAFLFFewaAIPSTLLAGWLSDKLFKGRRmpLAMICMALIFIC--LIGYWKSESLLMVTVFA 356
Cdd:cd17490 219 PLIAkqLGASSFQLGLLSIIYLLP---NALASLLSGTLFYKKLGERN--TIIIGFLLLGAYcfLIPFAPNLTLLYLLQAL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 357 AIVGCLIYVPQFLASVqtMEIVPSFAVGSAVGLrgFMS-YIFGASLGTSLFGVMVDKMGWHGGFYLL-MGGIVCCILFCY 434
Cdd:cd17490 294 NGFGTGILFPLLMSLS--IEGVPAEQRSTAMGF--FQAiYALGMFLGPVLVGIISEAFGLQTGFFVIgVIALLAAILSLA 369
|
.
gi 490203636 435 L 435
Cdd:cd17490 370 Y 370
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
9-177 |
1.23e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.08 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 9 PSANKVPAEKIQATYGRYRMQALLSVFLGYLAYYIVRNNFTLSTP-YLKEQLDLSATQIGLLSSC--------MLIAygi 79
Cdd:cd17471 179 VKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPlYVTNELGGSESWVGLLFGLaaaleipiMLLA--- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 80 skGVmssLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG--MGVGpsfITIANWFPRRERGRVGAF 157
Cdd:cd17471 256 --GL---LAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGitAGLG---ISYFQDLMPGQPGLATTL 327
|
170 180
....*....|....*....|...
gi 490203636 158 WNISHNVG---GGIVAPIVGAAF 177
Cdd:cd17471 328 YSNASRIGsllGGLLAGVIAQYF 350
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
53-178 |
1.64e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 43.75 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17390 20 STHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKH 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490203636 133 -MGVGPSFitIANWFPRRER----GRVGAFWNIshnvgGGIVAPIVGAAFA 178
Cdd:cd17390 100 tQSLCKAY--LSDLVSEQERsrvlGRFNAASSL-----GFILGPVVGGHLA 143
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
53-213 |
3.50e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.55 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQG 132
Cdd:cd17359 25 PFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGTEHWQSAS---YIVPACV--AVVFAISVLVL 207
Cdd:cd17359 105 GASALVPMYIAEVAPAEIRGRLVSLNQLM-IVFGQLLAYIVNYLIANAGGADWLGAEgwrWMLGLEAipAILFLLGMLFI 183
|
....*.
gi 490203636 208 GKgSPR 213
Cdd:cd17359 184 PE-SPR 188
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
83-360 |
7.03e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 83 VMSSLAD-KASPKVFMACGLVLCAIVNVGLGFST--AFWIFAALVVLnGLFqGMGVGPSFI-----TIAnwfPRRERGRV 154
Cdd:COG2270 71 VLGAIADrSGRKKPFLAFFTLLGVLATAALFFVApgGLWLGLLLFVL-ANI-GFEGSLVFYnaflpDIA---TPEEIGRV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 155 GAFwnishnvG------GGIVAPIVGAAFAI----LGTEHWQSASYIVPACVAVVFAISVLVL------GKGSPREEGLP 218
Cdd:COG2270 146 SGL-------GwalgylGGVLLLLINLALFLkpeaFGLPDAGEAVRISFLLTALWWLLFALPLflflpeRPRPGPAPPRG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 219 SLEEMMPEEKVVLKTkhnqqapenmsafqifctyVLRNKNAWY--VSFvdvFVY-MVRFGMISWLPIYLLTVKHFSKEQM 295
Cdd:COG2270 219 AVRAGFRELRRTLRE-------------------LRRYRDLLRflLAY---FFYrDGVQTVIAFAGIYAAGVLGFSTTEL 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490203636 296 SVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFICLIGYWkSESLLMVTVFAAIVG 360
Cdd:COG2270 277 IVFGLLVQIVAALGALLFGRLDDRI--GPKRVILVSLVIWIVVCLAAYF-LTTALAFWILGLLIG 338
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
32-140 |
8.02e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 41.43 E-value: 8.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 32 LSVFLGYLayyivrnNFTLStPYLkEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKAS-PKVFMACGLVLCAIVNVG 110
Cdd:cd17385 213 GSVSLGFL-------DPTLS-PHL-RQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITGVGFLL 283
|
90 100 110
....*....|....*....|....*....|....*.
gi 490203636 111 LG------FSTAFWIFAALVVLNGLFQGMGVGPSFI 140
Cdd:cd17385 284 LGpapllpIKSELWMVIIGLVLLGLSLGAALVPTFP 319
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
62-355 |
8.08e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 8.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 62 SATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFIT 141
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 142 IANWFPRRERGRVG----AFWNIshnvgGGIVAPIVgaAFAIlgtEHWQsASYIVPACVAVVFAISVLVLGKgSPR---- 213
Cdd:TIGR00898 205 NTEFLPKKQRAIVGtliqVFFSL-----GLVLLPLV--AYFI---PDWR-WLQLAVSLPTFLFFLLSWFVPE-SPRwlis 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 214 ----EEGLPSLEE--------MMPEEKVVLKTKHNQQAPENMSAFQIFCTYVLRNKN--AWYVSFVDVFVYmvrFGMisw 279
Cdd:TIGR00898 273 qgriEEALKILQRiakingkkLPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTlcLMMLWFTTAFSY---YGL--- 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 280 lpIYLLTVKHFSkeqMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLA-------MICMALIFICLIGYWKSESLLMV 352
Cdd:TIGR00898 347 --VLDLGNLGGN---IYLDLFISGLVELPAKLITLLLIDRL--GRRYTMAaslllagVALLLLLFVPVDLYFLRTALAVL 419
|
...
gi 490203636 353 TVF 355
Cdd:TIGR00898 420 GKF 422
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
280-459 |
1.16e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 280 LPIYLLTVKHfSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMAL--IFICLIGYWKSESLLMVTVFAA 357
Cdd:cd06173 22 LPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALlaAVLALLALLGSLSLWLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 358 IVGCL--IYVPQFLASVQtmEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYL 435
Cdd:cd06173 101 LLGIAsaFFGPARQALLP--ELVPKEQLVRANALNS-LATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLF 177
|
170 180
....*....|....*....|....
gi 490203636 436 SHRGALELEQQRKITEQEEARLAL 459
Cdd:cd06173 178 IRRPPPAAPGESSSLLLRDLREGL 201
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
53-212 |
1.29e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 41.07 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNvglgFSTAFWIFAALVVLNGLFQG 132
Cdd:PLN00028 60 PIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAV----FCMSLVSSATGFIAVRFFIG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 133 MGvGPSFITIANW----FPRRERGRVGAF---WNishNVGGG---IVAPIVGAAFAILG---TEHWQSAsYIVPACVAVV 199
Cdd:PLN00028 136 FS-LATFVSCQYWmstmFNGKIVGTANGIaagWG---NLGGGvtqLLMPLVFPLIKDAGapsFTAWRIA-FFVPGLLHII 210
|
170
....*....|...
gi 490203636 200 FAISVLVLGKGSP 212
Cdd:PLN00028 211 MGILVLTLGQDLP 223
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
262-453 |
1.61e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 262 VSFVDVFVYMVRFGMISWLPIYLLTvKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLI 341
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF--GRK-RLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 342 GYWKSESLLMVTVFAAIVGclIYVPQFLASVQT--MEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGF 419
Cdd:cd17489 77 LYLLATSVALLLVLRLIHG--IGWGAFTTAAATlvADIIPPSRRGEGIGYYGLATTL-AMALGPALGLFLYQHLGFAVLF 153
|
170 180 190
....*....|....*....|....*....|....
gi 490203636 420 YLLMGGIVCCILFCYLSHRGALELEQQRKITEQE 453
Cdd:cd17489 154 IVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRA 187
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
32-432 |
1.68e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.70 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 32 LSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKA-SPKVFMACGLVLCAIVnVG 110
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFgSRRVTRLGALLLLLAL-LL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFWIFAALVVLNGLFQGMG---VGPSFITIANWFPRRERGRVGAFWNIshnvgGGIVAPIVGAAFAILGTEHWqs 187
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGALdvaMNAQGVAVERAYGRPIMSSLHAMWSL-----GGLAGALLGAAAIGAGVSPG-- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 188 ASYIVpacVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLktkhnqqapenmsafqifctyVLRNKNAWYVSFVDV 267
Cdd:cd17393 154 VHLLA---AAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGF---------------------LLPNRLLLLLGLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFICLIgywkse 347
Cdd:cd17393 210 AAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDR-FGDVAVLRAGALLAALGLLLA------ 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 348 sLLMVTVFAAIVGCLIY-------VPQFLASVQTMeivPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFY 420
Cdd:cd17393 283 -LLAPSVWVALAGFALMglglsvvVPLAFSAAGAL---PGLAAGIAVARVATLGYL-GFLVGPPLIGFLADATGLRTAFL 357
|
410
....*....|..
gi 490203636 421 LLMGGIVCCILF 432
Cdd:cd17393 358 VVALLALLVALL 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
28-209 |
2.64e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 28 MQALLSVFLGYLAYYIVRNNFTLstpYLKEQLDLSATQIGLLSSCMLIAYGISKG-VMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17330 177 RRLLLVYFLIALAFAGLESVFSL---FLKDRFGFSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 107 VNVGLGFSTAFWIFAALVVLNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehwq 186
Cdd:cd17330 254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG----- 328
|
170 180
....*....|....*....|...
gi 490203636 187 saSYIVPACVAVVFAISVLVLGK 209
Cdd:cd17330 329 --PGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
54-432 |
3.26e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 54 YLKEQLDLSATQIGLLSSCM-LIAYGISKgVMSSLADKASP-KVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLnglFQ 131
Cdd:cd17471 22 FLTEELGASPLQIGIFMTLSaLSGIVVSQ-WLGRLSDRGGDrKPLILLALLAGALGYLLFAFLRNYWVLLLVGVV---LL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 132 GMGvGPSF---ITIANWFPRRERGRVGAFWN------IShnvgggiVAPIVG--AAFAILGteHWQ-SASYIVPACVAVV 199
Cdd:cd17471 98 SLG-AAAFpqlFALAREYADRSSGRDATLFNsvlraaFS-------LAWVIGppLAFLLLD--VLGfTGLFLLAALLYLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 200 FAISVLVlgkgspreeglpsleeMMPEEKVVLKTKHNQQAPENmsafqifctyVLRNKNAWYVSFVDVFVYMVRFGMISW 279
Cdd:cd17471 168 VALLVLF----------------LLPSVKPPAQKATPASSLVK----------APVNRRLLLLFAAFTLLFAANSMYIIA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 280 LPIYLLTVKHFSKEQMSVAF---LFFEwaaIPSTLLAGWLSDKLFKGRRMPLAMICMALIFiclIGYWKSESLLMV---- 352
Cdd:cd17471 222 MPLYVTNELGGSESWVGLLFglaAALE---IPIMLLAGLLAKRFGKRRLLLAGFLAGVLFY---LGLALATSLWQLialq 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 353 ----TVFAAIVGCLIYVPQFLASVQtmeivpsfaVGSAVGLRGFMSYIfGASLGTSLFGVMVDKMGWHGGFYLLMGGIVC 428
Cdd:cd17471 296 llnaIFIGITAGLGISYFQDLMPGQ---------PGLATTLYSNASRI-GSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
|
....
gi 490203636 429 CILF 432
Cdd:cd17471 366 ALVL 369
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
83-165 |
3.87e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.10 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 83 VMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQ-GMGVGPSFITIANWFPRReRGRVGAFWNIS 161
Cdd:cd17317 44 LFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSaGIFTVGFVLGMEIVGPKY-RSFVGILFGLF 122
|
....
gi 490203636 162 HNVG 165
Cdd:cd17317 123 WALG 126
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
262-435 |
4.07e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 262 VSFVDVFVYMVRFGMISWLPIYLlTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLI 341
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF--GRR-PVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 342 GYWKSESLLMVTVFAAIVGcLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVD--KMGWHGGF 419
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLG-LGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVF 155
|
170
....*....|....*.
gi 490203636 420 YLLMGGIVCCILFCYL 435
Cdd:cd06174 156 LIAAALALLAAILLLL 171
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
31-431 |
5.84e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 31 LLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17352 5 VFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 111 LGFSTAFW-IFAALVVLNGLFQGMGVGPSFITIANWFPRReRGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehWQSAS 189
Cdd:cd17352 85 SSFATSLWqLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKK-RGLATGIAVAGSGVGTFVFPPLLRYLLDNYG---WRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 190 YIVPACVAVVFAISVLVLgkgspreeglpsleemmpeekvvlktkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFV 269
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR---------------------------------------------LLKDPTFVLLALGVSFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 270 YMVRFGMISWLPIYLLTVKhFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFICLIGYWKSESL 349
Cdd:cd17352 196 MLGFFVPFVYLPSYAKSLG-IDESDAAFLLSIIGISDIVGRILLGLLADK-PRIGRLYLYIFTLLILGLSLLAFPLATTY 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 350 LMVTVFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGL-RGFMSyiFGASLGTSLFGVMVDKMG-WHGGFY----LLM 423
Cdd:cd17352 274 VGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLvLLFQG--LAALVGPPIAGLLRDYTGdYDAAFYfcgaCLL 351
|
....*...
gi 490203636 424 GGIVCCIL 431
Cdd:cd17352 352 LSGVLLFL 359
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
51-433 |
6.30e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 51 STPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVgLGFSTAFWIFAALVV---LN 127
Cdd:cd17318 43 TLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL-LTPLAARGGYGALIVlriLQ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 128 GLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGtehWQSASYIVpACVAVVFAISVLVL 207
Cdd:cd17318 122 GLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG---WPSIFYIF-GGLGLLWCLLWFFL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 208 GkgspreeglpsleemmpeekvvlktkhnqqapenMSAFQIFCTYVLRNknawyvsfvdvFVYMVrfgMISWLPIYLLTV 287
Cdd:cd17318 198 V----------------------------------LPVWAIVVAHFGHN-----------WGFYT---LLTELPTYMSDV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 288 KHFSKEqmSVAFL----FFewAAIPSTLLAGWLSDKLFKGRRMPL-----AMICMALI----FICLIGYWKSESLLMVTV 354
Cdd:cd17318 230 LHFNIK--SNGFLsslpYL--AMWICSIVGGYLADWLRSRGILSTttvrkLFTSIGFLgpgvFLIALGYLGSNATLAVVF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 355 FAAIVGCL-IYVPQFLASVQtmEIVPSFAvGSAVGLRGFMSYIFGAsLGTSLFGVMV----DKMGWHGGFYLLMG-GIVC 428
Cdd:cd17318 306 LTLSVGLSgACYSGFLVNHL--DLAPNYA-GTLMGITNTAATIAGI-ISPLIVGAIVkndqTIGQWRIVFFISAAiYILG 381
|
....*
gi 490203636 429 CILFC 433
Cdd:cd17318 382 AIFYL 386
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
307-435 |
7.24e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.71 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 307 IPSTLLAGWLSDKLfkGRRmPLAMICMALIFICLI------GYWKSESLLMVTVFAAIVGCLIYVPQFLASVQTM----- 375
Cdd:cd17358 288 VVGTLVATLLVDRL--GRR-PLLLVSAIGMGIGLLalglyfYLQEHGALLSSVSWLPLVGLVIYIISFSIGLGPLpwvim 364
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490203636 376 -EIVPSFAVGSAVGLRGFMSYIFgASLGTSLFGVMVDKMGWHGGFYLLMGGIVCCILFCYL 435
Cdd:cd17358 365 sEIFPAKIKGLAGSLVTLVNWLF-AFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLL 424
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
35-419 |
8.43e-03 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 38.21 E-value: 8.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 35 FLGYLAYYIVRNNFTLSTPYLKEQLdLSATQIGLLSSCMLIAYGISKGVMSSLADK--ASPKVFMACGLVlCAIVNVGLG 112
Cdd:pfam03825 9 VMMFLQFFIWGAWLVTLGSYMFVTG-FDGASIGAVYSSLGIAAIFMPALLGIIADRwfSAERVLAVCHLI-GAITLFMAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 113 FSTAFWIFAALVVLNGLFQ----GMGVGPSFITIANwfPRRERGRVGAFWNISHNVGGGIVAPIVGaAFAILGTEHWQsa 188
Cdd:pfam03825 87 QVTTFEAFFLVILVNSLAYmptlALTNSIAFANLQD--PVTDFPPIRVWGTIGWIMASWPFVMWVV-SLAGFELSHMQ-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 189 sYIVPACVAVVFAISVLVLGKGSPREEGLPSLEEMMPEEKVVLKTKhnqqapENMSAFqIFCTYVLRNKNAWYVSFVDVF 268
Cdd:pfam03825 162 -LLIAAGLSALLVLFALTLPHTPAKQKANQSWTTLLGLDAFALLKN------KRMAVF-FIFSFLLGAELQIYNVFANTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 269 VYMvRFGMISWLPIYLLTVKHFSKeqmsvaflffewaaIPSTLLAGWLSDKLFKGRRMPLAMICMALIFICLIGYWKSES 348
Cdd:pfam03825 234 LTS-FDKFIVKHASIIMSLGQISE--------------ILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGADPTP 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490203636 349 LLMVTVFAAIV--GCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKMGWHGGF 419
Cdd:pfam03825 299 FGTALLLLSMIvhGVAYDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGIT 371
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
99-363 |
8.64e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.35 E-value: 8.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 99 CGLVLCAIVNVGLGFSTAFWIFAALVVLnglfqGMGVGPSFITI--ANWFPR-----RERGRVGAFWNISHNVGGGIVAP 171
Cdd:cd17332 80 LALLFVLLFTTPDGSGTGKLIYALITYI-----LLDLLYTLVNIpyTALIPEltddpEERTSLTSWRMFFATIGGLLVTV 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 172 IVGAAFAILGTEHWQSASYIVPACVAVVFAISVLVLGKGSpREEGLPSleemmpeekvvlktkhnQQAPENMSAFQIFCt 251
Cdd:cd17332 155 LPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT-RERVVPP-----------------EEEKSKLPLLKSLK- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 252 YVLRNKNAWYVSFVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFewAAIPSTLLAGWLSDKLFKGRRmpLAMI 331
Cdd:cd17332 216 ALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLIL--SGALLALLPWPPLKKRFGKKK--AFFI 291
|
250 260 270
....*....|....*....|....*....|..
gi 490203636 332 CMALIFICLIGYWKSESLLMVTVFAAIVGCLI 363
Cdd:cd17332 292 GLLLAILGLLLLFFLPPGNLVLILVLAVLAGI 323
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
67-338 |
9.35e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 9.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 67 GLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSTAFWIFAALVVLNGLFQGMgVGPSFITIANWF 146
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGY-VPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 147 PRRERGRV-GAFWNIShnVGGGIVAPIVGAAFA-ILGTehwQSASYIVPACVAVVFAISVLVLgkgspREEGLPSLEEMM 224
Cdd:cd17391 118 PKEKSGWAlGTLSTGV--VAGTLIGPLLGGFLAdLFGI---RNVFFITGGLLFLAFLLTLFFV-----KEDFKPVEKKKM 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490203636 225 PEEKVVLKtkhnqqapenmsafqifctyVLRNKNAWYVSFVDVFVymVRFGMISWLPIYLLTVKHFSKEQMSVAF---LF 301
Cdd:cd17391 188 VSTKEVWN--------------------SVPNPSLLISLFVTTFI--IQLANQSIEPILTLYIRQLMGDASNLAFisgLV 245
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 490203636 302 FEWAAIPSTLLAGW---LSDKLFKGRRMPLAMICMALIFI 338
Cdd:cd17391 246 FSATGVSSLLSAPRlgkLGDRIGHHRILLGALLASALLYI 285
|
|
| |
