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Conserved domains on  [gi|490206699|ref|WP_004105118|]
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MULTISPECIES: propanediol diffusion facilitator PduF [Klebsiella]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-254 1.07e-82

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 247.35  E-value: 1.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   4 SLKAQCTAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRK 83
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  84 VFPYIVSQVAGAFGGAVLAYVLYSTMFTEFEsahhiargsvESLQLASIFSTYPAASLSIWHAALVEVVITSMLMGMIMA 163
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 164 LTDDGNgvPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMagwgdiaMTGGRDIPYFIVPIIAPLIGAC 243
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                        250
                 ....*....|.
gi 490206699 244 LGAAIYRYLIG 254
Cdd:COG0580  222 LAALLYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-254 1.07e-82

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 247.35  E-value: 1.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   4 SLKAQCTAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRK 83
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  84 VFPYIVSQVAGAFGGAVLAYVLYSTMFTEFEsahhiargsvESLQLASIFSTYPAASLSIWHAALVEVVITSMLMGMIMA 163
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 164 LTDDGNgvPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMagwgdiaMTGGRDIPYFIVPIIAPLIGAC 243
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                        250
                 ....*....|.
gi 490206699 244 LGAAIYRYLIG 254
Cdd:COG0580  222 LAALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 8-252 8.56e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 242.54  E-value: 8.56e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   8 QCTAEFLGTGLFLFFGIGCLSALKVAG-ASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFP 86
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCGSVLAVKLAGgASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  87 YIVSQVAGAFGGAVLAYVLYSTMFTEFESAHHIARGsveslqlasIFSTYPAASLSIWHAALVEVVITSMLMGMIMALTD 166
Cdd:cd00333   82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG---------IFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 167 DGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMAgwgdiamtggRDIPYFIVPIIAPLIGACLGA 246
Cdd:cd00333  153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA----------RHWHYFWVYWVGPLIGAIAGA 222


                 ....*.
gi 490206699 247 AIYRYL 252
Cdd:cd00333  223 LVYDYV 228
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 8-254 1.15e-58

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 188.41  E-value: 1.15e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   8 QCTAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFPY 87
Cdd:PTZ00016  52 EYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  88 IVSQVAGAFGGAVLAYVLYSTMFTEFESAHHIARGSveSLQLASIFSTYPAASL--SIWHaalvEVVITSMLMGMIMALT 165
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETM--ANGFAGVFATYPREGNfyAIFS----ELILTAILLLVILAIT 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 166 DDGNGVPKGPLaPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMAgWGDIAMTggRDIPYFIVPIIAPLIGACLG 245
Cdd:PTZ00016 206 DPNNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFT--KDNYYFWVPLVAPFVGAVLG 281


                 ....*....
gi 490206699 246 AAIYRYLIG 254
Cdd:PTZ00016 282 MFLYDKFIP 290
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-249 3.65e-58

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 184.83  E-value: 3.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699    4 SLKAQCTAEFLGTGLFLFFGIGCLSALKVAGASL---GLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFP 80
Cdd:pfam00230   6 SFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   81 GRKVFPYIVSQVAGAFGGAVLAYVLYStmftefesahhiargsveSLQLASIFSTYPAASLSIWHAALVEVVITSMLMGM 160
Cdd:pfam00230  86 LLRAIFYIVAQLLGAIAGAALLYGVTV------------------GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYC 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  161 IMALTDDGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWmagwgdiamtggrDIPYFIVPIIAPLI 240
Cdd:pfam00230 148 VFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLW-------------KWDDHWVYWVGPFI 214


                  ....*....
gi 490206699  241 GACLGAAIY 249
Cdd:pfam00230 215 GAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 11-249 1.09e-57

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 183.27  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   11 AEFLGTGLFLFFGIGC-----LSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVF 85
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSalgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   86 PYIVSQVAGAFGGAVLAYVLYSTMFtefESAHHIARGsveslqlasifstyPAASLSIWHAALVEVVITSMLMGMIMALT 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF---PGNLAVNGS--------------ASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  166 DDGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMAGWGDiamtggrdipyFIVPIIAPLIGACLG 245
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN-----------HWVYWVGPIIGAILG 212


                  ....
gi 490206699  246 AAIY 249
Cdd:TIGR00861 213 ALVY 216
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-254 1.07e-82

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 247.35  E-value: 1.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   4 SLKAQCTAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRK 83
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  84 VFPYIVSQVAGAFGGAVLAYVLYSTMFTEFEsahhiargsvESLQLASIFSTYPAASLSIWHAALVEVVITSMLMGMIMA 163
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 164 LTDDGNgvPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMagwgdiaMTGGRDIPYFIVPIIAPLIGAC 243
Cdd:COG0580  151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                        250
                 ....*....|.
gi 490206699 244 LGAAIYRYLIG 254
Cdd:COG0580  222 LAALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 8-252 8.56e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 242.54  E-value: 8.56e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   8 QCTAEFLGTGLFLFFGIGCLSALKVAG-ASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFP 86
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCGSVLAVKLAGgASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  87 YIVSQVAGAFGGAVLAYVLYSTMFTEFESAHHIARGsveslqlasIFSTYPAASLSIWHAALVEVVITSMLMGMIMALTD 166
Cdd:cd00333   82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG---------IFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 167 DGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMAgwgdiamtggRDIPYFIVPIIAPLIGACLGA 246
Cdd:cd00333  153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA----------RHWHYFWVYWVGPLIGAIAGA 222


                 ....*.
gi 490206699 247 AIYRYL 252
Cdd:cd00333  223 LVYDYV 228
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 8-254 1.15e-58

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 188.41  E-value: 1.15e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   8 QCTAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFPY 87
Cdd:PTZ00016  52 EYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  88 IVSQVAGAFGGAVLAYVLYSTMFTEFESAHHIARGSveSLQLASIFSTYPAASL--SIWHaalvEVVITSMLMGMIMALT 165
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETM--ANGFAGVFATYPREGNfyAIFS----ELILTAILLLVILAIT 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 166 DDGNGVPKGPLaPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMAgWGDIAMTggRDIPYFIVPIIAPLIGACLG 245
Cdd:PTZ00016 206 DPNNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFT--KDNYYFWVPLVAPFVGAVLG 281


                 ....*....
gi 490206699 246 AAIYRYLIG 254
Cdd:PTZ00016 282 MFLYDKFIP 290
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-249 3.65e-58

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 184.83  E-value: 3.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699    4 SLKAQCTAEFLGTGLFLFFGIGCLSALKVAGASL---GLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFP 80
Cdd:pfam00230   6 SFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   81 GRKVFPYIVSQVAGAFGGAVLAYVLYStmftefesahhiargsveSLQLASIFSTYPAASLSIWHAALVEVVITSMLMGM 160
Cdd:pfam00230  86 LLRAIFYIVAQLLGAIAGAALLYGVTV------------------GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYC 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  161 IMALTDDGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWmagwgdiamtggrDIPYFIVPIIAPLI 240
Cdd:pfam00230 148 VFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLW-------------KWDDHWVYWVGPFI 214


                  ....*....
gi 490206699  241 GACLGAAIY 249
Cdd:pfam00230 215 GAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 11-249 1.09e-57

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 183.27  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   11 AEFLGTGLFLFFGIGC-----LSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVF 85
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSalgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   86 PYIVSQVAGAFGGAVLAYVLYSTMFtefESAHHIARGsveslqlasifstyPAASLSIWHAALVEVVITSMLMGMIMALT 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF---PGNLAVNGS--------------ASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  166 DDGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWMAGWGDiamtggrdipyFIVPIIAPLIGACLG 245
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN-----------HWVYWVGPIIGAILG 212


                  ....
gi 490206699  246 AAIY 249
Cdd:TIGR00861 213 ALVY 216
PRK05420 PRK05420
aquaporin Z; Provisional
 8-254 4.73e-26

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 101.97  E-value: 4.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   8 QCTAEFLGTgLFLFFGiGCLSALKVAG---ASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKV 84
Cdd:PRK05420   4 KLAAEFFGT-FWLVFG-GCGSAVLAAAfpeLGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  85 FPYIVSQVAGAFGGAVLAYVlystmftefesahhIARGSVESLQLASIFST--YPAAS---LSIWHAALVEVVITSMLMG 159
Cdd:PRK05420  82 VPYIIAQVVGGIAAAAVLYL--------------IASGKAGFDLAGSGFASngYGEHSpggYSLLAALVCEVVLTAFFLL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 160 MIMALTDdgNGVPKGpLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFtwmagwgdiamTGGRDIPYFIVPIIAPL 239
Cdd:PRK05420 148 VILGATD--KRAPAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALF-----------VGGWALEQLWLFWVAPI 213

                        250
                 ....*....|....*
gi 490206699 240 IGACLGAAIYRYLIG 254
Cdd:PRK05420 214 VGAIIGGLIYRLLLE 228
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-259 1.85e-25

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 101.47  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  11 AEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFPYIVS 90
Cdd:PLN00183  50 AEMVGTFILMFCVCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  91 QVAGAFGGAVLAYVLYSTMftefesahhiargsveslqlASIFSTYPAASLSiwHAALVEVVITSMLMGMIMALTDDGNG 170
Cdd:PLN00183 130 QTVGSVLATYVGVSVYGVK--------------------ADLMTTKPAQGCS--SAFWVEFIATFIVMFLAASLTSQPQS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 171 VpkGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWmagwgdiamtggrDIPYFIVPIIAPLIGACLGAAIYR 250
Cdd:PLN00183 188 L--GHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSW-------------DFKDIWIYITAPTIGAVAGALMFH 252


                 ....*....
gi 490206699 251 YLIGNNLPC 259
Cdd:PLN00183 253 LLRLRTQPC 261
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 11-252 1.32e-21

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 91.12  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  11 AEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFPYIVS 90
Cdd:PLN00182  47 AEMIGTYFIIFSGCGVVVVNVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  91 QvagaFGGAVLAYVLYSTMFTEFESAhhiargsveslqlasIFSTYPAASLSiwHAALVEVVITSMLMGMIMALTDDGNG 170
Cdd:PLN00182 127 Q----LTGSLLASLTLRLMFNVTPEA---------------FFGTTPTDSSG--QALVAEIIISFLLMFVISGVATDSRA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 171 VpkGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPklftwmagwgdiAMTGGRdIPYFIVPIIAPLIGACLGAAIYR 250
Cdd:PLN00182 186 V--GELAGIAVGMTIILNVFVAGPISGASMNPARSLGP------------AIVMGR-YKGIWVYIVGPFVGIIAGGFVYN 250


                 ..
gi 490206699 251 YL 252
Cdd:PLN00182 251 LI 252
PLN00184 PLN00184
aquaporin NIP1; Provisional
 11-249 1.19e-19

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 86.23  E-value: 1.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  11 AEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVFPYIVS 90
Cdd:PLN00184  59 AEVLGTYFLVFTGCASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVIS 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  91 QVAGAFGGAVLAYVLYSTMFTEFESAHHIARGSveslqlasifstypAASLSIWHAALVEVVITSMLMGMIMALTDDGNG 170
Cdd:PLN00184 139 QVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGS--------------SPVGSDLQAFVMEFIVTFYLMFIISGVATDNRA 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 171 VpkGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLF--TWMAGWgdiamtggrdipyfiVPIIAPLIGACLGAAI 248
Cdd:PLN00184 205 I--GELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVygCYKGIW---------------IYIVAPTLGAIAGAWV 267


                 .
gi 490206699 249 Y 249
Cdd:PLN00184 268 Y 268
PLN00026 PLN00026
aquaporin NIP; Provisional
 4-249 3.94e-14

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 70.66  E-value: 3.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   4 SLKAQCTAEFLGTGLFLFFGIGCLSALKVAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRK 83
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAGPIVNQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKH 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  84 VFPYIVSQVAGAFGGAVLAYVLYstmftefesaHHIARGSVeslqlasifsTYPAASLSiwHAALVEVVITSMLMGMIMA 163
Cdd:PLN00026 149 VPAYIAAQVSASICASFALKGVF----------HPFMSGGV----------TVPSVSTG--QAFALEFIITFNLLFVVTA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 164 LTDDGNGVpkGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKlftwmagwgdIAMTGGRDIPYFIVpiiAPLIGAC 243
Cdd:PLN00026 207 VATDTRAV--GELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPA----------VAAGNYRAIWIYLV---APTLGAL 271


                 ....*.
gi 490206699 244 LGAAIY 249
Cdd:PLN00026 272 AGAGTY 277
PLN00166 PLN00166
aquaporin TIP2; Provisional
 4-249 1.07e-12

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 66.11  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   4 SLKAQCTaEFLGTGLFLFFGIGCLSALK--VAGASL---GLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFAC 78
Cdd:PLN00166  17 SLKAYLS-EFIATLLFVFAGVGSAIAFAklTSDAALdpaGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGN 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  79 FPGRKVFPYIVSQVAGAFGGAVLAYVLYSTmftefesahhiargsveslqlASIFSTYPAASLSIWHAALVEVVITSMLM 158
Cdd:PLN00166  96 ITIITGFFYWIAQCLGSIVACLLLVFVTNG---------------------ESVPTHGVAAGLGAIEGVVMEIVVTFALV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 159 GMIMALTDDGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPklftwmagwgdiAMTGGrDIPYFIVPIIAP 238
Cdd:PLN00166 155 YTVYATAADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGP------------AVVSG-DFSQIWIYWVGP 221

                        250
                 ....*....|.
gi 490206699 239 LIGACLGAAIY 249
Cdd:PLN00166 222 LVGGALAGLIY 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 3-249 1.27e-11

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 62.88  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699   3 DSLKAqCTAEFLGTGLFLFFGIG---CLSALKVAGASL--GLWEICIIWGLGISLAVYLTSGISGGHLNPAVTvalwlFA 77
Cdd:PLN00027  18 DALKA-ALAEFISTLIFVFAGEGsgmAFNKLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVT-----FG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  78 CFPGRKV--FPYIVSQVAGAFGGAVLAYVLystmftefesahHIARGSVESlqlaSIFSTypAASLSIWHAALVEVVITS 155
Cdd:PLN00027  92 AFIGGNItlLRGILYWIAQLLGSVVACLLL------------KFSTGGLET----SAFSL--SSGVGVWNAFVFEIVMTF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 156 MLMGMIMALTDDGNGVPKGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPKLFTWmagwgdiamtggrDIPYFIVPI 235
Cdd:PLN00027 154 GLVYTVYATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSW-------------TWTNHWVYW 220

                        250
                 ....*....|....
gi 490206699 236 IAPLIGACLGAAIY 249
Cdd:PLN00027 221 AGPLIGGGIAGLVY 234
PLN00167 PLN00167
aquaporin TIP5; Provisional
 11-249 3.24e-09

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 56.06  E-value: 3.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  11 AEFLGTGLFLFFGIGCLSALK-----VAGASLGLWEICIIWGLGISLAVYLTSGISGGHLNPAVTVALWLFACFPGRKVF 85
Cdd:PLN00167  27 AEFISTFFFVFAAVGSAMSSRklmpdAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTAM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699  86 PYIVSQvagafggaVLAYVLYSTMFTEFESAHHIARGSVeslqlasifstypAASLSIWHAALVEVVITSMLMGMIMALT 165
Cdd:PLN00167 107 FYWISQ--------MLASVMACLFLKVTTVGQHVPTYKI-------------AEEMTGFGASVLEGVLTFGLVYTVYAAG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490206699 166 DDGNGVPkGPLAPLLIGLLVAVIGASTGPLTGFAMNPARDFGPklftwmagwgdiAMTGGRdIPYFIVPIIAPLIGACLG 245
Cdd:PLN00167 166 DPRRGLL-GAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGS------------AVVAGS-FKNQAVYWVGPLLGGAVA 231


                 ....
gi 490206699 246 AAIY 249
Cdd:PLN00167 232 GLLY 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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