|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05370 |
PRK05370 |
argininosuccinate synthase; Validated |
1-445 |
0e+00 |
|
argininosuccinate synthase; Validated
Pssm-ID: 235434 Cd Length: 447 Bit Score: 995.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 1 MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRKKGAVPYAYTANLGQPDEDDYEAIPRRAKEYGAEGARLIDCRKQLVAE 80
Cdd:PRK05370 1 MSTILKHLPVGQRVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCRAQLVAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 81 GIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDS 160
Cdd:PRK05370 81 GIAAIQCGAFHISTGGVTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNPELKIYKPWLDQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 161 DFIDELGGRQEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSVKIVNPIMGVKFWDESVKIPAEEVTVR 240
Cdd:PRK05370 161 DFIDELGGRAEMSEFLIAHGFDYKMSVEKAYSTDSNMLGATHEAKDLEHLNSGIKIVNPIMGVAFWDEDVEIKAEEVTVR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 241 FEQGHPVALNGQTFSDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQY 320
Cdd:PRK05370 241 FEQGRPVALNGKTFSDPVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 321 HAHGRQLGRLLYQGRWFDSQALMLRDGLQRWVASQITGEVTLELRRGNDYSILNTVSDNLTYKAERLTMEKG-DSMFSAE 399
Cdd:PRK05370 321 RINGRRLGRLLYQGRWFDPQALMLRESLQRWVASAITGEVTLELRRGNDYSILNTVSPNLTYKPERLSMEKVeSAAFSPD 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 490207692 400 DRIGQLTMRNLDITDTRDKLFGYAQSGLLTASSATGLPQVENLENK 445
Cdd:PRK05370 401 DRIGQLTMRNLDITDTREKLFIYAKTGLLSSGEASGLPQLENLENK 446
|
|
| argG |
TIGR00032 |
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ... |
13-420 |
0e+00 |
|
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987 Cd Length: 394 Bit Score: 599.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 13 RIGIAFSGGLDTSAALLWMRKKGAVPYAYTANLGQPdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAE-GIAAIQCGAFH 91
Cdd:TIGR00032 1 KVVLAYSGGLDTSVCLKWLREKGYEVIAYTADVGQP-EEDIDAIPEKALEYGAENHYTIDAREEFVKDyGFAAIQANAFY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 92 NTTggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDFIdelggRQE 171
Cdd:TIGR00032 80 EGT----YPLSTALARPLIAKKLVEAAKKEGANAVAHGCTGKGNDQERFERSIRLLNPDLKVIAPWRDLNFT-----REE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 172 MSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLnSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNG 251
Cdd:TIGR00032 151 EIEYAIQCGIPYPMSKEKPYSIDENLWGRSIEAGILEDP-STEPPEDIYMWTKFPDEATPDEPEVVTIDFEQGVPVALNG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 252 QTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLL 331
Cdd:TIGR00032 230 VSL-DPVELILEANEIAGKHGVGRIDIIENRIIGLKSREIYEAPGAALLIIAHRDLETLTLTRDVLEFKDIVEEQYSELI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 332 YQGRWFDSQALMLrDGLQRWVASQITGEVTLELRRGNDYSILNTvSDNLTYKAERLTMEKgDSMFSAEDRIGQLTMRNLD 411
Cdd:TIGR00032 309 YQGLWFDPLAEAL-DAFIRKTQERVTGTVRVKLFKGNAIVIGRT-SPYSLYDEELVSMEK-DDVFDPRDAIGFITMRGLQ 385
|
....*....
gi 490207692 412 ITDTRDKLF 420
Cdd:TIGR00032 386 IKDYREKKK 394
|
|
| ArgG |
COG0137 |
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ... |
12-416 |
1.05e-169 |
|
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907 Cd Length: 397 Bit Score: 481.87 E-value: 1.05e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 12 QRIGIAFSGGLDTSAALLWMRKK-GAVPYAYTANLGQpdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAEGIA-AIQCGA 89
Cdd:COG0137 1 KKVVLAYSGGLDTSVIIPWLKEKyGYEVIAVTADVGQ--GEDLEAIEEKALKLGASKAYVVDAREEFVEDYVFpAIKANA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 90 FHnttGGlTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDfideLGGR 169
Cdd:COG0137 79 LY---EG-KYPLGTALARPLIAKKLVEIAREEGADAVAHGCTGKGNDQVRFELAIRALAPDLKIIAPWREWD----LKSR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 170 QEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSVKivNPIMGVKFWDESVKIPAEEVTVRFEQGHPVAL 249
Cdd:COG0137 151 EEEIEYAEEHGIPVPATKEKPYSIDENLWGRSIEGGELEDPWNEPP--EDAYEWTVSPEDAPDEPEYVTITFEKGVPVAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 250 NGQTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGR 329
Cdd:COG0137 229 NGEKL-SPVELIEELNEIGGKHGVGRIDIVENRLVGIKSRGVYEAPGATILITAHRALESLTLDRETLHFKDILDQKYAE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 330 LLYQGRWFDSQALMLRDGLQRwVASQITGEVTLELRRGNdYSILNTVSDNLTYKAERLTMEKGDSmFSAEDRIGQLTMRN 409
Cdd:COG0137 308 LVYNGLWFSPLREALDAFIDE-TQKRVTGTVRLKLYKGN-ATVVGRKSPYSLYDEDLATYEEDDV-FDQKDAEGFIKLFG 384
|
....*..
gi 490207692 410 LDITDTR 416
Cdd:COG0137 385 LPLRVAA 391
|
|
| ASS |
cd01999 |
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ... |
12-411 |
1.57e-142 |
|
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503 Cd Length: 386 Bit Score: 412.70 E-value: 1.57e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 12 QRIGIAFSGGLDTSAALLWMRKK-GAVPYAYTANLGQPDEDdyEAIPRRAKEYGAEGARLIDCRKQLVAEGIA-AIQCGA 89
Cdd:cd01999 1 KKVVLAYSGGLDTSVILKWLKEEyGYEVIAFTADLGQGDEE--EEIEEKALKLGAVKVYVVDLREEFAEDYIFpAIKANA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 90 FHNTTggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDFidelGGR 169
Cdd:cd01999 79 IYEGR----YPLGTALARPLIAKKLVEVAREEGATAVAHGCTGKGNDQVRFELAIKALAPDLKVIAPWRDWNF----LTR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 170 QEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNssvkiVNPIMGVKFWDESVKIP---AEEVTVRFEQGHP 246
Cdd:cd01999 151 AEEIAYAKKHGIPVPVTKKKPYSIDENLWGRSYEGGDLEDPW-----NEPPEDAFEWTVSPEKApdePEYVTIEFEKGVP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 247 VALNGQTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQ 326
Cdd:cd01999 226 VAVNGEKL-DPVELIEKLNEIAGRHGVGRIDIVENRLVGIKSRGVYEAPGATLLIKAHRDLEDLTLDREVLHFKDIVSRK 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 327 LGRLLYQGRWFDSQALMLRDGLQRWVASqITGEVTLELRRGNDYsILNTVSDNLTYKAERLTMEKGDSmFSAEDRIGQLT 406
Cdd:cd01999 305 YAELVYNGLWFDPLREALEAFIDKTQER-VTGEVRLKLYKGNVI-VVGRESPNSLYSEELATYEEGDG-FDQKDAEGFIK 381
|
....*
gi 490207692 407 MRNLD 411
Cdd:cd01999 382 IHGLQ 386
|
|
| Arginosuc_synth |
pfam00764 |
Arginosuccinate synthase; This family contains a PP-loop motif. |
16-394 |
6.55e-59 |
|
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148 Cd Length: 386 Bit Score: 197.95 E-value: 6.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 16 IAFSGGLDTSAALLWMRKKGAVPY-AYTANLGQPdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAEGI-AAIQCGAFHNT 93
Cdd:pfam00764 2 LAYSGGLDTSVCIPWLKEQGGYEViAVAVDVGQG-GEDIDEAREKALKLGAVKHYVIDAKEEFVEDYIfPAIQANALYED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 94 TggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDFIdelggRQEMS 173
Cdd:pfam00764 81 R----YPLGTALARPLIAKKLVEAAKKEGASAVAHGCTGKGNDQVRFEVSFRSLAPDLKVIAPVRDPNLT-----REEEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 174 EFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSvkivnPIMGVKFWDESVKIP---AEEVTVRFEQGHPVALN 250
Cdd:pfam00764 152 EYAEEHGIPIPVTKKSPYSIDENLWGRSIEAGILEDPWNA-----PPEDIYEWTKDPAKApdePDIVEIGFEKGVPVALD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 251 GQTFSDdVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL---HIAYERL-LTG--IHNEDTIEQyhahg 324
Cdd:pfam00764 227 GEPVSP-LELIEKLNEIAGAHGVGRIDIVEDRLVGIKSREIYEAPAATVLitaHRDLENLtLTRevLRFKRIVDQ----- 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490207692 325 rQLGRLLYQGRWFDSqalmLRDGLQRWVAS---QITGEVTLELRRGNDYsILNTVSDNLTYKAERLTMEKGDS 394
Cdd:pfam00764 301 -KWAELVYDGLWFSP----LKEALDAFIDKtqeRVTGTVRVKLHKGSAI-VLGRRSPYSLYDEELVSYDEGDT 367
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05370 |
PRK05370 |
argininosuccinate synthase; Validated |
1-445 |
0e+00 |
|
argininosuccinate synthase; Validated
Pssm-ID: 235434 Cd Length: 447 Bit Score: 995.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 1 MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRKKGAVPYAYTANLGQPDEDDYEAIPRRAKEYGAEGARLIDCRKQLVAE 80
Cdd:PRK05370 1 MSTILKHLPVGQRVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEDDYDAIPRRAMEYGAENARLIDCRAQLVAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 81 GIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDS 160
Cdd:PRK05370 81 GIAAIQCGAFHISTGGVTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNPELKIYKPWLDQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 161 DFIDELGGRQEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSVKIVNPIMGVKFWDESVKIPAEEVTVR 240
Cdd:PRK05370 161 DFIDELGGRAEMSEFLIAHGFDYKMSVEKAYSTDSNMLGATHEAKDLEHLNSGIKIVNPIMGVAFWDEDVEIKAEEVTVR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 241 FEQGHPVALNGQTFSDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQY 320
Cdd:PRK05370 241 FEQGRPVALNGKTFSDPVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 321 HAHGRQLGRLLYQGRWFDSQALMLRDGLQRWVASQITGEVTLELRRGNDYSILNTVSDNLTYKAERLTMEKG-DSMFSAE 399
Cdd:PRK05370 321 RINGRRLGRLLYQGRWFDPQALMLRESLQRWVASAITGEVTLELRRGNDYSILNTVSPNLTYKPERLSMEKVeSAAFSPD 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 490207692 400 DRIGQLTMRNLDITDTRDKLFGYAQSGLLTASSATGLPQVENLENK 445
Cdd:PRK05370 401 DRIGQLTMRNLDITDTREKLFIYAKTGLLSSGEASGLPQLENLENK 446
|
|
| argG |
TIGR00032 |
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ... |
13-420 |
0e+00 |
|
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987 Cd Length: 394 Bit Score: 599.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 13 RIGIAFSGGLDTSAALLWMRKKGAVPYAYTANLGQPdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAE-GIAAIQCGAFH 91
Cdd:TIGR00032 1 KVVLAYSGGLDTSVCLKWLREKGYEVIAYTADVGQP-EEDIDAIPEKALEYGAENHYTIDAREEFVKDyGFAAIQANAFY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 92 NTTggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDFIdelggRQE 171
Cdd:TIGR00032 80 EGT----YPLSTALARPLIAKKLVEAAKKEGANAVAHGCTGKGNDQERFERSIRLLNPDLKVIAPWRDLNFT-----REE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 172 MSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLnSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNG 251
Cdd:TIGR00032 151 EIEYAIQCGIPYPMSKEKPYSIDENLWGRSIEAGILEDP-STEPPEDIYMWTKFPDEATPDEPEVVTIDFEQGVPVALNG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 252 QTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLL 331
Cdd:TIGR00032 230 VSL-DPVELILEANEIAGKHGVGRIDIIENRIIGLKSREIYEAPGAALLIIAHRDLETLTLTRDVLEFKDIVEEQYSELI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 332 YQGRWFDSQALMLrDGLQRWVASQITGEVTLELRRGNDYSILNTvSDNLTYKAERLTMEKgDSMFSAEDRIGQLTMRNLD 411
Cdd:TIGR00032 309 YQGLWFDPLAEAL-DAFIRKTQERVTGTVRVKLFKGNAIVIGRT-SPYSLYDEELVSMEK-DDVFDPRDAIGFITMRGLQ 385
|
....*....
gi 490207692 412 ITDTRDKLF 420
Cdd:TIGR00032 386 IKDYREKKK 394
|
|
| ArgG |
COG0137 |
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ... |
12-416 |
1.05e-169 |
|
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907 Cd Length: 397 Bit Score: 481.87 E-value: 1.05e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 12 QRIGIAFSGGLDTSAALLWMRKK-GAVPYAYTANLGQpdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAEGIA-AIQCGA 89
Cdd:COG0137 1 KKVVLAYSGGLDTSVIIPWLKEKyGYEVIAVTADVGQ--GEDLEAIEEKALKLGASKAYVVDAREEFVEDYVFpAIKANA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 90 FHnttGGlTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDfideLGGR 169
Cdd:COG0137 79 LY---EG-KYPLGTALARPLIAKKLVEIAREEGADAVAHGCTGKGNDQVRFELAIRALAPDLKIIAPWREWD----LKSR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 170 QEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSVKivNPIMGVKFWDESVKIPAEEVTVRFEQGHPVAL 249
Cdd:COG0137 151 EEEIEYAEEHGIPVPATKEKPYSIDENLWGRSIEGGELEDPWNEPP--EDAYEWTVSPEDAPDEPEYVTITFEKGVPVAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 250 NGQTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGR 329
Cdd:COG0137 229 NGEKL-SPVELIEELNEIGGKHGVGRIDIVENRLVGIKSRGVYEAPGATILITAHRALESLTLDRETLHFKDILDQKYAE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 330 LLYQGRWFDSQALMLRDGLQRwVASQITGEVTLELRRGNdYSILNTVSDNLTYKAERLTMEKGDSmFSAEDRIGQLTMRN 409
Cdd:COG0137 308 LVYNGLWFSPLREALDAFIDE-TQKRVTGTVRLKLYKGN-ATVVGRKSPYSLYDEDLATYEEDDV-FDQKDAEGFIKLFG 384
|
....*..
gi 490207692 410 LDITDTR 416
Cdd:COG0137 385 LPLRVAA 391
|
|
| ASS |
cd01999 |
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ... |
12-411 |
1.57e-142 |
|
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503 Cd Length: 386 Bit Score: 412.70 E-value: 1.57e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 12 QRIGIAFSGGLDTSAALLWMRKK-GAVPYAYTANLGQPDEDdyEAIPRRAKEYGAEGARLIDCRKQLVAEGIA-AIQCGA 89
Cdd:cd01999 1 KKVVLAYSGGLDTSVILKWLKEEyGYEVIAFTADLGQGDEE--EEIEEKALKLGAVKVYVVDLREEFAEDYIFpAIKANA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 90 FHNTTggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDFidelGGR 169
Cdd:cd01999 79 IYEGR----YPLGTALARPLIAKKLVEVAREEGATAVAHGCTGKGNDQVRFELAIKALAPDLKVIAPWRDWNF----LTR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 170 QEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNssvkiVNPIMGVKFWDESVKIP---AEEVTVRFEQGHP 246
Cdd:cd01999 151 AEEIAYAKKHGIPVPVTKKKPYSIDENLWGRSYEGGDLEDPW-----NEPPEDAFEWTVSPEKApdePEYVTIEFEKGVP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 247 VALNGQTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQ 326
Cdd:cd01999 226 VAVNGEKL-DPVELIEKLNEIAGRHGVGRIDIVENRLVGIKSRGVYEAPGATLLIKAHRDLEDLTLDREVLHFKDIVSRK 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 327 LGRLLYQGRWFDSQALMLRDGLQRWVASqITGEVTLELRRGNDYsILNTVSDNLTYKAERLTMEKGDSmFSAEDRIGQLT 406
Cdd:cd01999 305 YAELVYNGLWFDPLREALEAFIDKTQER-VTGEVRLKLYKGNVI-VVGRESPNSLYSEELATYEEGDG-FDQKDAEGFIK 381
|
....*
gi 490207692 407 MRNLD 411
Cdd:cd01999 382 IHGLQ 386
|
|
| Arginosuc_synth |
pfam00764 |
Arginosuccinate synthase; This family contains a PP-loop motif. |
16-394 |
6.55e-59 |
|
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148 Cd Length: 386 Bit Score: 197.95 E-value: 6.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 16 IAFSGGLDTSAALLWMRKKGAVPY-AYTANLGQPdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAEGI-AAIQCGAFHNT 93
Cdd:pfam00764 2 LAYSGGLDTSVCIPWLKEQGGYEViAVAVDVGQG-GEDIDEAREKALKLGAVKHYVIDAKEEFVEDYIfPAIQANALYED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 94 TggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDSDFIdelggRQEMS 173
Cdd:pfam00764 81 R----YPLGTALARPLIAKKLVEAAKKEGASAVAHGCTGKGNDQVRFEVSFRSLAPDLKVIAPVRDPNLT-----REEEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 174 EFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSvkivnPIMGVKFWDESVKIP---AEEVTVRFEQGHPVALN 250
Cdd:pfam00764 152 EYAEEHGIPIPVTKKSPYSIDENLWGRSIEAGILEDPWNA-----PPEDIYEWTKDPAKApdePDIVEIGFEKGVPVALD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 251 GQTFSDdVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL---HIAYERL-LTG--IHNEDTIEQyhahg 324
Cdd:pfam00764 227 GEPVSP-LELIEKLNEIAGAHGVGRIDIVEDRLVGIKSREIYEAPAATVLitaHRDLENLtLTRevLRFKRIVDQ----- 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490207692 325 rQLGRLLYQGRWFDSqalmLRDGLQRWVAS---QITGEVTLELRRGNDYsILNTVSDNLTYKAERLTMEKGDS 394
Cdd:pfam00764 301 -KWAELVYDGLWFSP----LKEALDAFIDKtqeRVTGTVRVKLHKGSAI-VLGRRSPYSLYDEELVSYDEGDT 367
|
|
| PRK00509 |
PRK00509 |
argininosuccinate synthase; Provisional |
13-400 |
9.84e-57 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 234785 Cd Length: 399 Bit Score: 192.20 E-value: 9.84e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 13 RIGIAFSGGLDTSAALLWMRKK-GAVPYAYTANLGQpdEDDYEAIPRRAKEYGAEGARLIDCRKQLVAEGIA-AIQCGAF 90
Cdd:PRK00509 4 KVVLAYSGGLDTSVIIKWLKETyGCEVIAFTADVGQ--GEELEPIREKALKSGASEIYVEDLREEFVRDYVFpAIRANAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 91 hnttggltYFNTTPLG----RAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERF---YrYGLltNAELKIYKPWLDSDFi 163
Cdd:PRK00509 82 --------YEGKYPLGtalaRPLIAKKLVEIARKEGADAVAHGCTGKGNDQVRFelgI-AAL--APDLKVIAPWREWDL- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 164 delGGRQEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSSVK------IVNPimgVKFWDEsvkipAEEV 237
Cdd:PRK00509 150 ---KSREELIAYAEEHGIPIPVTKKSPYSIDANLWHRSIEGGILEDPWNEPPedvyewTVSP---EDAPDE-----PEYV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 238 TVRFEQGHPVALNGQTFSDdVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL--LT----GI 311
Cdd:PRK00509 219 EIEFEKGVPVAINGEALSP-AELIEELNELAGKHGIGRIDIVENRLVGIKSRGVYETPGGTILIKAHRALesLTldreVA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 312 HNEDTIEQYHAHgrqlgrLLYQGRWFDS-----QALMlrDGLQRWVasqiTGEVTLELRRGNDYsILNTVSDNLTYKAER 386
Cdd:PRK00509 298 HFKDELEPKYAE------LVYNGLWFSPlrealQAFI--DETQEHV----TGEVRLKLYKGNAI-VVGRKSPNSLYDEDL 364
|
410
....*....|....
gi 490207692 387 LTMEKGDSmFSAED 400
Cdd:PRK00509 365 ATYEEDDV-YDQKD 377
|
|
| PLN00200 |
PLN00200 |
argininosuccinate synthase; Provisional |
16-410 |
6.36e-52 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 177791 Cd Length: 404 Bit Score: 179.94 E-value: 6.36e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 16 IAFSGGLDTSAALLWMRKK-GAVPYAYTANLGQPDEDdYEAIPRRAKEYGAEGARLIDCRKQLVAEGI-AAIQCGAFHNT 93
Cdd:PLN00200 10 LAYSGGLDTSVILKWLRENyGCEVVCFTADVGQGIEE-LEGLEAKAKASGAKQLVVKDLREEFVRDYIfPCLRANAIYEG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 94 TggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYR--YGLltNAELKIYKPWLDSDFIdelgGRQE 171
Cdd:PLN00200 89 K----YLLGTSMARPLIAKAMVDIAKEVGADAVAHGATGKGNDQVRFELtfFAL--NPELKVVAPWREWDIK----GRED 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 172 MSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLE----------FLNSsvkiVNPimgvkfwdESVKIPAEEVTVRF 241
Cdd:PLN00200 159 LIEYAKKHNIPVPVTKKSIYSRDRNLWHISYEGDILEdpanepkedmFMMS----VSP--------EAAPDQPEYIEIEF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 242 EQGHPVALNGQTFSDdVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYH 321
Cdd:PLN00200 227 EKGLPVAINGKTLSP-ATLLTKLNEIGGKHGIGRIDMVENRFVGMKSRGVYETPGGTILFAAHRELESLTLDRETMQVKD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 322 AHGRQLGRLLYQGRWFDSQALMLRDGLQRwVASQITGEVTLELRRGNdYSILNTVSDNLTYKAERLTMEKGDSMFSAED- 400
Cdd:PLN00200 306 SLALKYAELVYNGFWFDPERESMDAFMEK-ITETTTGSVRLKLYKGN-VSVAGRKSPYSLYRQDISSFEEGGGIYNQADa 383
|
410
....*....|....
gi 490207692 401 ----RIGQLTMRNL 410
Cdd:PLN00200 384 agfiRLYALRLRTR 397
|
|
| PRK13820 |
PRK13820 |
argininosuccinate synthase; Provisional |
13-385 |
3.30e-33 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 237521 Cd Length: 394 Bit Score: 128.89 E-value: 3.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 13 RIGIAFSGGLDTSAALLWMRKKgavpYAY------TANLGQPDEDDYEAiPRRAKEYGAEgARLIDCRKQLVAEGIA-AI 85
Cdd:PRK13820 4 KVVLAYSGGLDTSVCVPLLKEK----YGYdevitvTVDVGQPEEEIKEA-EEKAKKLGDK-HYTIDAKEEFAKDYIFpAI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 86 QCGAFHNTtggltYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERF---YRyglltNAELKIYKPwldsdf 162
Cdd:PRK13820 78 KANALYEG-----YPLGTALARPLIAEKIVEVAEKEGASAIAHGCTGKGNDQLRFeavFR-----ASDLEVIAP------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 163 IDELG-GRQEMSEFMISCGFDYKMSVEKAYSTDSNMLGATHEAKDLEflNSSVKIVNPIMGvkfWDES---VKIPAEEVT 238
Cdd:PRK13820 142 IRELNlTREWEIEYAKEKGIPVPVGKEKPWSIDENLWSRSIEGGKLE--DPAFEPPEEIYA---WTVSpedAPDEPEIVE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 239 VRFEQGHPVALNGQTFsDDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL---HIAYERL-LTG--IH 312
Cdd:PRK13820 217 IEFEEGVPVAINGEKM-DGVELIRKLNEIAGKHGVGRTDMMEDRVLGLKSRENYEHPAATVLltaHKALEQLvLTReeLK 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490207692 313 NEDTIEQyhahgrQLGRLLYQGRWFDSqalmLRDGLQRWVA---SQITGEVTLELRRGNdYSILNTVSDNLTYKAE 385
Cdd:PRK13820 296 FKEIVDS------KWAELAYEGLVDEP----LREDLNAFIDktqERVTGTVTVKLYKGS-ARVVGRESPYALYSEE 360
|
|
| PRK04527 |
PRK04527 |
argininosuccinate synthase; Provisional |
12-382 |
8.51e-25 |
|
argininosuccinate synthase; Provisional
Pssm-ID: 235305 Cd Length: 400 Bit Score: 105.30 E-value: 8.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 12 QRIGIAFSGGLDTSAALLWMRKKGAVPYAYTANLGQPDEDDYEAIPRRAKEYGAEGARLIDCrKQLVAEGIAA--IQcga 89
Cdd:PRK04527 3 KDIVLAFSGGLDTSFCIPYLQERGYAVHTVFADTGGVDAEERDFIEKRAAELGAASHVTVDG-GPAIWEGFVKplVW--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 90 fhnttGGLTYFNTTPLGRAVTGTMLVAAMK---EDGVNIWGDGSTYKGNDIERFYRyGLLTNAELKIYKPWldSDFIDEL 166
Cdd:PRK04527 79 -----AGEGYQGQYPLLVSDRYLIVDAALKraeELGTRIIAHGCTGMGNDQVRFDL-AVKALGDYQIVAPI--REIQKEH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 167 GG-RQEMSEFMISCGFDYKMSvEKAYSTDSNMLGATHEAKDLEflnssvKIVNPIMGVKFW-DESVKIPAEEVTVR--FE 242
Cdd:PRK04527 151 TQtRAYEQKYLEERGFGVRAK-QKAYTINENLLGVTMSGGEID------RWEAPGEGARGWcAPRSAWPTEALTVTikFV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490207692 243 QGHPVALNGQTFSdDVELMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERL----LTGIHNedtie 318
Cdd:PRK04527 224 EGEAVALDGKPLP-GAQILAKLNKLFAQYGVGRGVYTGDTVIGLKGRIVFEAPGLVSLLTAHRALedavLTKQQN----- 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490207692 319 QYHAH-GRQLGRLLYQGRWFDSqalmLRDGLQRWVAS---QITGEVTLELRRG-------NDYSILNtvSDNLTY 382
Cdd:PRK04527 298 RFKPDvARKWVELVYEGFYHDP----LKTDIEAFLKSsqaKVNGEVTLETRGGrvdavavRSPHLLN--SKGATY 366
|
|
| TilS |
COG0037 |
tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]; tRNA ... |
3-64 |
1.28e-03 |
|
tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]; tRNA(Ile)-lysidine synthase TilS/MesJ is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 439807 [Multi-domain] Cd Length: 235 Bit Score: 40.20 E-value: 1.28e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490207692 3 TILKH--LPVGQRIGIAFSGGLDtSAALL-----WMRKKGAVPYAYTANLGQPDE--DDYEAIPRRAKEYG 64
Cdd:COG0037 5 AIRDYrlLEPGDRILVAVSGGKD-SLALLhllakLRRRLGFELVAVHVDHGLREEsdEDAEFVAELCEELG 74
|
|
| QueC-like |
cd01995 |
7-cyano-7-deazaguanine synthase QueC and similar proteins; 7-cyano-7-deazaguanine synthase (EC ... |
18-72 |
3.09e-03 |
|
7-cyano-7-deazaguanine synthase QueC and similar proteins; 7-cyano-7-deazaguanine synthase (EC 6.3.4.20) is also called 7-cyano-7-carbaguanine synthase, preQ(0) synthase, or queuosine biosynthesis protein QueC. It catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)), as part of the biosynthesis pathway of queuosine (Q). Q is one of the most complex modifications occurring at the wobble position of tRNAs with GUN anticodons, and is implicated in a number of biological activities, including accuracy of decoding, virulence, and cellular differentiation. This subfamily belongs to the adenine nucleotide alpha hydrolase (AANH) superfamily that also includes other N-type ATP PPases and ATP sulfurylases. It forms an alpha/beta/alpha fold which binds to the adenosine group.
Pssm-ID: 467499 [Multi-domain] Cd Length: 208 Bit Score: 38.75 E-value: 3.09e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 490207692 18 FSGGLDTSAALLWMRKKGAVPYAYTANLGQPDEDDYEAIPRRAKEYGAEGARLID 72
Cdd:cd01995 7 LSGGLDSTTLLYWALKEGYEVHALTFDYGQRHAKEELEAAKLIAKLLGIEHKVID 61
|
|
| |
