|
Name |
Accession |
Description |
Interval |
E-value |
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-394 |
0e+00 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 580.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 1 MKRHKNFNLLLMLVLLVAVGQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGM 80
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 81 SIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWN 160
Cdd:PRK11652 81 SIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 161 WRACFVFLLILCAGVTFSMARWMPETRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGL 240
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 241 SSMSVSILFILPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLA 320
Cdd:PRK11652 241 SSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGMLFPLA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490208724 321 TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMMPQTGQGSLGLLMMLMGLLILLCWLPLASRFHQHQQPV 394
Cdd:PRK11652 321 TSGAMEPFPYLAGTAGALLGGLQNIGSGLAALLSAMLPQTGQFSLGLLMTLMGLLILLCWLPLATRMSHQGQPV 394
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-362 |
6.78e-85 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 263.28 E-value: 6.78e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVL 99
Cdd:cd17320 11 GPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 100 IAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSM 179
Cdd:cd17320 91 LIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMPETRPTGAPRT---RLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAA 256
Cdd:cd17320 171 LLFLPETLPEEKRKPllsSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 257 FFGAWFAGRPNKRF--PTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGT 334
Cdd:cd17320 251 ILGSLLNGRLVRRFgpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGT 330
|
330 340
....*....|....*....|....*...
gi 490208724 335 AGALVGGLQNIGSGVLAWLSAMMPQTGQ 362
Cdd:cd17320 331 ASALLGFLQFLIGALAGALVGLLPNGTA 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-349 |
1.09e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.95 E-value: 1.09e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:COG2814 24 LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMAR 181
Cdd:COG2814 104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPETRPtgAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAFFGAW 261
Cdd:COG2814 184 LLPESRP--AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 262 FAGRPNKRFPtLMWQSVICCLLAGVLMWIPGLLGvmTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVG 340
Cdd:COG2814 262 LAGRLADRFG-RRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYN 338
|
....*....
gi 490208724 341 GLQNIGSGV 349
Cdd:COG2814 339 SAFFLGGPL 347
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-343 |
3.91e-37 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 138.67 E-value: 3.91e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVL 99
Cdd:TIGR00710 17 GPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 100 IAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSM 179
Cdd:TIGR00710 97 LVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMPETRPTGApRTRLITNYKT---LFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAA 256
Cdd:TIGR00710 177 FFILPETLPYEA-RIQISTYFETfllLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAM 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 257 FFGAWFAGRPNKRF--PTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGT 334
Cdd:TIGR00710 256 IFGGFLNGRFIKKWgaKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGT 335
|
....*....
gi 490208724 335 AGALVGGLQ 343
Cdd:TIGR00710 336 ASALFGTLR 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-357 |
1.47e-28 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 114.57 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 28 IPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQG 107
Cdd:cd17324 19 QGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 108 MGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPETR 187
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 188 PTGAPRTRLITNYKTLFGTGAFncYLLMLIGGLAGIAVFEACS--GVLMGAVLGLSSMSVSILFILPIPAAFFGAWFAGR 265
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRL--RLAYLITFLLFGGFFALYTylAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 266 PNKRFPTLMWqSVICCLLAGVLMWIPGLLGVMtvWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNI 345
Cdd:cd17324 257 LADRGGRRAL-LIALLLLAAALLLLTLLGPSP--LLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNL 333
|
330
....*....|..
gi 490208724 346 GSGVLAWLSAMM 357
Cdd:cd17324 334 GGALGAALGGLV 345
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-356 |
4.25e-28 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 113.47 E-value: 4.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 27 YIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQ 106
Cdd:PRK11102 10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 107 GMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPET 186
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 187 RPTGApRTRL-----ITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAFFGAW 261
Cdd:PRK11102 170 LPKER-RQPFhlrttIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFLFVMTI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 262 FAGRPNKRF-PTLMWQ-SVICCLLAGVLMWIPGLLGVmTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALV 339
Cdd:PRK11102 249 INSRFVRRVgALNMLRfGLWIQFIMGIWLVVSALLDL-GFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMAGTASSLA 327
|
330
....*....|....*...
gi 490208724 340 GGLQ-NIGSGVLAWLSAM 356
Cdd:PRK11102 328 GTLRfGIGAIVGALLSLA 345
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-186 |
1.51e-27 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 105.81 E-value: 1.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 52 YLLTYGVSQLFYGPLS----DRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEG 127
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 490208724 128 AQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPET 186
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-349 |
5.15e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.64 E-value: 5.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIA-DMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLI 100
Cdd:pfam07690 10 LGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 101 AASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMA 180
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 181 RWMPET-----RPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEacSGVLMGAVLGLSSMSVSILFILPIPA 255
Cdd:pfam07690 170 LPRPPPeskrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 256 AFFGAWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGT 334
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeERGT 327
|
330
....*....|....*
gi 490208724 335 AGALVGGLQNIGSGV 349
Cdd:pfam07690 328 ASGLYNTAGSLGGAL 342
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-349 |
1.20e-22 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 98.01 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVL 99
Cdd:cd17321 8 AALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 100 IAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSM 179
Cdd:cd17321 88 IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 arwmpetrptgapRTRLITNYKTLFGTGAFNCYLLMLIgglagiavfeacsgVLMGAVLGLSSMSVSILFILPIPAAFFG 259
Cdd:cd17321 168 -------------RTFSGAVLAAFLLGAALGGLLFLLP--------------LYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 260 AWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGTAGAL 338
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKeKAGAASGI 300
|
330
....*....|.
gi 490208724 339 VGGLQNIGSGV 349
Cdd:cd17321 301 LNTARQLGGAL 311
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-322 |
2.69e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.48 E-value: 2.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMAR 181
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPETRPTGAPRT----RLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAF 257
Cdd:cd17325 170 LLPEPRPPPNKRAvsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490208724 258 FGAWFAGRPNKRFPTLMWqSVICCLLAGVLMWIPGLLGvmTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLA 311
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-357 |
2.70e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.48 E-value: 2.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:cd17474 13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILdTLWNWRACFVFLLILCAGVTFSMAR 181
Cdd:cd17474 93 GRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPET-RPTGAPRTRLITNYKTLFGTGAFncyLLMLIGGLAGIAVFEAC---SGVLMGAVLGLSSMSVSILFILPIPAAF 257
Cdd:cd17474 172 LLPEPkEKAKSSSATKLRDLKKALRGRGL---LTFLVSAFLYFFLYFAFltyLPFLLELLYGISPIIIGLLFAGWSVLLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 258 FGAWFAGRPNKRFPTLMWQSVICCLLAGVLMWIpgLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAG 336
Cdd:cd17474 249 LGSLFVGRLLKKRFGARRILVIGLLLYALSLLL--LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPeEERGTAS 326
|
330 340
....*....|....*....|.
gi 490208724 337 ALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd17474 327 SLYNFVRFLGQAVGPLLFGLL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-265 |
4.17e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 89.48 E-value: 4.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:COG0477 28 LDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILcAGVTFSMAR 181
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL-GLLALVLRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPETRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAFFGAW 261
Cdd:COG0477 187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
....
gi 490208724 262 FAGR 265
Cdd:COG0477 267 LLLL 270
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
26-355 |
8.27e-20 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 90.08 E-value: 8.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 26 IYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASAL 105
Cdd:PRK10473 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 106 QGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPE 185
Cdd:PRK10473 101 QGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 186 TRPTGAPRTR-LITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLS----SMSVSILFILPIPAAFFGA 260
Cdd:PRK10473 181 TRPARAPAASsKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSrgeyAIIMALTAGVSMTVSFSTP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 261 WFAGRPNKRfpTLMWQSVICCLLAGVLmwipgLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVG 340
Cdd:PRK10473 261 FALGIFKPR--TLMLTSQVLFLAAGIT-----LALSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLG 333
|
330
....*....|....*
gi 490208724 341 GLQNIGSGVLAWLSA 355
Cdd:PRK10473 334 IAQVCGSSLWIWLAA 348
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-343 |
1.99e-19 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 89.18 E-value: 1.99e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVL 99
Cdd:PRK11043 18 GFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 100 IAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILcAGVTFSM 179
Cdd:PRK11043 98 LVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAI-TLLLILP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMPETRPTGAPRTRLITnYKTLFGTGAFncyllmliggLAGIAVFEACSG-----------VL--MG---AVLGLSSM 243
Cdd:PRK11043 177 TLRLKPSKKARKQSQDALT-FKQLLKSKTY----------LGNVLIFAACSAaffawltgspfILeqMGyspADIGLSYV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 244 SVSILFILpipAAFFGAWFAGR--PNKRFPTLMWQSVICCllagVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLAT 321
Cdd:PRK11043 246 PQTIAFLV---GGYGCRAALQKwgGEQLLPWLLVLFAVSV----IAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVV 318
|
330 340
....*....|....*....|..
gi 490208724 322 SGAMEPFPFLAGTAGALVGGLQ 343
Cdd:PRK11043 319 AQALRPFPQATGKAAALQNTLQ 340
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
20-357 |
3.68e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 84.93 E-value: 3.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVL 99
Cdd:cd17323 11 VTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAML 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 100 IAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSM 179
Cdd:cd17323 91 IILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMPETrptgaprtrlitnyktlfgtgafnCYLLMLIGGLAGI--AVFEACSGVLMGaVLGLSSMSVSILFILPIPAAF 257
Cdd:cd17323 171 FLFLPIV------------------------LLLGLYVGLVYAIlyLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 258 FGAWFAGR------------------PNKRFPTLMWQSVicCLLAGVLM----------WIPGLLGvmtvwtllvpaaLF 309
Cdd:cd17323 226 IGSIIGGRlsdyyyrrlkkknggkpePEARLPPAFIGAF--LFPIGLFIfgwtiyphihWIVPIIG------------SA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 490208724 310 FFGAGMLFPLATSGA--MEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd17323 292 FFGFGLMLIFQSSLTylVDSYPKYAASALAANTLVRSIFAAIFPLFAQPM 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-357 |
2.92e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 2.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 30 AIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMG 109
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 110 TGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVtfsmarwmpetrpt 189
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLL-------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 190 gaprtrlitnykTLFGTGAFNCYLLMLIGGLAGIAVFeacSGVLMGAVLGLSSMSVSILFILP----IPAAFFGAWFAGR 265
Cdd:COG2271 178 ------------ALLRFWLLALAYFLVYFALYGFLTW---LPTYLVEVRGLSLAQAGLLLSLPflagIVGSLLGGWLSDR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 266 PNKRFPTLMwqsVICCLLAGVLMWIPGLLGvmTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQN 344
Cdd:COG2271 243 LGRRRKLVL---AIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGF 317
|
330
....*....|...
gi 490208724 345 IGSGVLAWLSAMM 357
Cdd:COG2271 318 LGGALGPLLVGYL 330
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
20-357 |
9.84e-17 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 81.08 E-value: 9.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVL 99
Cdd:cd17503 8 AILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 100 IAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSM 179
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ArwmpetrptgAPRTRLITNYKTLFGTgafncyLLMLIGGLAGIAVFEACSgVLMGAVLGLSSMSVSILFILPIPAAFFG 259
Cdd:cd17503 168 P----------LLDLRLFKDRNFTLGL------LLSFLLGLGLFGAMFLLP-LYLQNVLGYSAFESGLVLAPGGLASAIL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 260 AWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLF-PLATSGAMEPFPFLAGTAGAL 338
Cdd:cd17503 231 SPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFmPLNTLALNSLPPEQIGDATAL 310
|
330 340
....*....|....*....|
gi 490208724 339 VGGLQNIGSGV-LAWLSAMM 357
Cdd:cd17503 311 FNTIRQLGGSIgTALLATLL 330
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
37-264 |
2.42e-15 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 76.90 E-value: 2.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 37 SLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVM 116
Cdd:PRK15402 42 DFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 117 ARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPETrpTGAPRTR- 195
Cdd:PRK15402 122 GYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPET--AGRVGEKl 199
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490208724 196 ----LITNYKTLFGTGAFNCYLLMLigGLAGIAVFE--ACSGVLMGAVLGLSSMSVSILFIlPIpaafFGAWFAG 264
Cdd:PRK15402 200 slkeLGRDYKLVLKNRRFVAGALAL--GLVSLPLLAwiALSPVILISGEQLSSYEYGLLQV-PV----FGALIAG 267
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-357 |
5.62e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.54 E-value: 5.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDT--LWNWRACFVFLLILCAGVTFSM 179
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMPETRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSG------VLMGAVLGLSSMSVSILFILPI 253
Cdd:cd06174 170 LLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSfstllpLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 254 PAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLvpAALFFFGAGMLFPLATSGAMEPFPF-LA 332
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL--LLLLGFGLGGLLPLSFALIAELFPPeIR 327
|
330 340
....*....|....*....|....*
gi 490208724 333 GTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd06174 328 GTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-357 |
1.45e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.45 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:COG2223 19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMAR 181
Cdd:COG2223 99 LGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPET-RPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSIL-FILPIPAAF-- 257
Cdd:COG2223 179 FLRDPpAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLaALFALLGALgr 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 258 -FGAWFAGRPNKRfPTLMWQSVICCLLAGVLMWIPGllgvmTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:COG2223 259 pLGGWLSDRIGGR-RVLLIVFALMALGLLLLALALG-----SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTkNAGAV 332
|
330 340
....*....|....*....|..
gi 490208724 336 GALVGGLQNIGSGVLAWLSAMM 357
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGAL 354
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
50-347 |
4.70e-13 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 69.51 E-value: 4.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 50 AAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEGAQ 129
Cdd:cd17502 37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 130 LRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILcAGVTFSMARwmpetrptgaprtrlitnyktlfgtGAF 209
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPI-GGLALALLR-------------------------TIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 210 NCYLLMLIGGLAGIAVFeACSGVLMGAVLGLSSMSVSILFILPIPAAFFGAWFAGR---PNKRFPTLMWQSVICCLLAGV 286
Cdd:cd17502 171 LSSIFGFLFGGALFGLI-YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGAlisKTGRYKPLIVIGTILMSVGAG 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490208724 287 LMWIpgLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGS 347
Cdd:cd17502 250 LLTT--LTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPpADVGVATATNTFFRSLGG 309
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
43-251 |
2.21e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.47 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 43 GAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPR 122
Cdd:cd17329 35 SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 123 DLYEGAQLRHANSLLNMGILVSPLLAPLIGGILdTLWNWRACFVFLLILCAGVTFSMARWMPETRPTGAPR--TRLITNY 200
Cdd:cd17329 115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAekTEILRGY 193
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 490208724 201 KTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFIL 251
Cdd:cd17329 194 KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL 244
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-330 |
3.60e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 3.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVS-LNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLI 100
Cdd:cd17473 13 MAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 101 AASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLwNWRACF-VFLLILCAGVTfsM 179
Cdd:cd17473 93 ASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFlVYLLALPVLIL--V 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMPETRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAFFG 259
Cdd:cd17473 170 LLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490208724 260 AWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGLLGvmtVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF 330
Cdd:cd17473 250 ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG---LWVVLLGAILAGLGFGLLLPTLNSWAMSLVPP 317
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-353 |
7.62e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.89 E-value: 7.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 30 AIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMG 109
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 110 TGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRAcfVFLLILCAGVTFSMARWMpetrpt 189
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW--AFIIEGLLGLLLAVLWWF------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 190 gaprtRLITNYKTLFGTGAFNCYLLMLIGGLAGIavfeacsgvlMGAVLGLSSMSVSILFILPIPAAFFGAWFAGRPNKR 269
Cdd:cd17319 177 -----YLRQVWGLALGYFGINYALYGLLTWLPTY----------LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 270 FPTL--MWQSVICCLLAGVlmwipGLLGVMTVWTLLVPAALF---FFGAGMLFPLATSGAMEPFPF-LAGTAGALVGGLQ 343
Cdd:cd17319 242 LLRGarRLVIIIGLLLAAV-----GLLLAYLTTSPVVAVILLslaGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGG 316
|
330
....*....|
gi 490208724 344 NIGSGVLAWL 353
Cdd:cd17319 317 NLGGFVAPLL 326
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-322 |
7.65e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 7.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 43 GAVQSVMAAYLLTYGVSQLFYGPLSDRVG-----RRPVILVGMSIFMLATLIAITTHSLP------VLIAASALQGMGTG 111
Cdd:COG2211 46 ALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 112 VGGVMARTLPRDLYEGAQLR-HANSLLNMGILVSPLLAPLIGGIL------DTLWNWRACFVFLLILCAGVTFSMARWMP 184
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERtRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 185 ETRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAFFGAWFAG 264
Cdd:COG2211 206 ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 490208724 265 RPNKRFPTLMWqSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:COG2211 286 RLAKRFGKKKA-FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-318 |
1.37e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.14 E-value: 1.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 26 IYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASAL 105
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 106 QGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPE 185
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 186 TRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLA--GIAVFEAcsgvLMGAVLGLSsmSVSILFILPIPAAFFGAWFA 263
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAygAISTFLP----LYAAERGIS--NAGLFFTVYAIALLLSRPFS 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 490208724 264 GRPNKRFPTLMwQSVICCLLAGVLMWIPGLLGvmTVWTLLVPAALFFFGAGMLFP 318
Cdd:cd17489 248 GKLSDRKGPKT-VIIPGLLLLALGLLLLSFAG--SPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-360 |
1.76e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 58.74 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 21 QMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLI 100
Cdd:cd17504 9 MLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 101 AASALQgMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMA 180
Cdd:cd17504 89 AGRALQ-GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 181 rwMPETRPTGAPRTRLITNYKTLFGTGAFncyllMLIGGLAGIAVFEACSGVLMGAVL-GLSSMSVSIlfilpipAAFFG 259
Cdd:cd17504 168 --LIDLRLLRRRNVLLANITALLAGFGMF-----MVFQLLPQLLQLPTPTGFGLGITEaGLLLLPGAL-------VMLIA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 260 AWFAGRPNKRF---PTLMWQSVICCLLAGVLMWIPGllgvmTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:cd17504 234 GPLAGRLIARVgprRVLLIGLVISAVGLLLLALLHS-----SLWALVVALLLIGIGLGLAFASLPNIVVESVPPdRTGIA 308
|
330 340
....*....|....*....|....*
gi 490208724 336 GALVGGLQNIGSGVLAWLSAMMPQT 360
Cdd:cd17504 309 TGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
60-318 |
1.60e-08 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 55.99 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 60 QLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNM 139
Cdd:PRK15403 68 QWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 140 GILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPET-----RPTGAPRT-----RLITNYKTLFGTGAF 209
Cdd:PRK15403 148 IVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETvkrgaVPFSAKSVlrdfrNVFRNRLFLTGAATL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 210 NCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVsilFILPIPAAFFGAWFAGRPNKrfPTLMWQSVICCLLAGVLMW 289
Cdd:PRK15403 228 SLSYIPMMSWVAVSPVILIDAGGMTTSQFAWTQVPV---FGAVIVANAIVARFVKDPTE--PRFIWRAVPIQLVGLALLI 302
|
250 260
....*....|....*....|....*....
gi 490208724 290 IPGLLGVMTVWTLLVPAALFFFGAGMLFP 318
Cdd:PRK15403 303 VGNLLWPHVWLWSVLGTSLYAFGIGLIFP 331
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-322 |
4.51e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.53 E-value: 4.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 49 MAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMArtLPRDLYEGA 128
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMA--LLADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 129 QLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPETRPTGAPRTRLITNYKTLFGTGA 208
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 209 FNC-YLLMLIGGLAGIAVFEACSGVLMGAVLGLSSM------SVSILFILPIPAAFfgawFAGRPNKRFPTLMwQSVICC 281
Cdd:cd17472 196 LLRlDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLwkvylpAILIGFILMVPFVI----YAEKKGKMKQVFV-SSILLI 270
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 490208724 282 LLAGVLMWipglLGVMTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:cd17472 271 AVGFLLLL----FAATSLWLLIIGLIIFFIGFNLLEALLPS 307
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
21-349 |
7.25e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 53.81 E-value: 7.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 21 QMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLI 100
Cdd:cd17476 11 QAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 101 AASALQGMGTGVGGVMARTLPRDLYEGAQLRH-ANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAgVTFSM 179
Cdd:cd17476 91 ICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAA-IVAVA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 180 ARWMpetrptgaprtrlitnyktlfGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAAFFG 259
Cdd:cd17476 170 AIFW---------------------TSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 260 AWFAGRPNKRFPT--LMWQSVICCLLAGVLMWIPglLGVMTVWTLLVPAALFF-FGAGMLFPLAT---SGAMEpfPFLAG 333
Cdd:cd17476 229 AITVGFLIARLPPsyIMAISMVAFLVGPILFATM--PVHQTYWAQAFPAMIVApFGMDFSFPAATiiaSNAVP--REYQG 304
|
330
....*....|....*.
gi 490208724 334 TAGALVGGLQNIGSGV 349
Cdd:cd17476 305 LAGSLVNTVVNYGISI 320
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
51-173 |
1.80e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.01 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 51 AYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMArTLPRDLYEGAQL 130
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGA-AVASELVPNKYR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 490208724 131 RHANSLLNMGILVSPLLAPLIGGIL--DTLWNWRACFVFLLILCA 173
Cdd:cd06179 119 GLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNA 163
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-353 |
2.13e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.55 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEgaqlRHANSLLNM-------GILVSPLL-APLIGGILDTLWNWRACFVFLLILCA 173
Cdd:COG0738 102 ALFLLGLGLGLLDVAANPYVAALGP----ETAASRLNLlhaffslGALLGPLLgGLLILLGLSLSWHLPYLILAVLLLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 174 GVTFSMARwMPETRPTGAPRTRLITNYKTLFGTGAFncyLLMLIGGLAGIAVFEAC---SGVLMGAVLGLSSMSVSILFI 250
Cdd:COG0738 178 ALLFLRSK-LPEIEEEEEEAAGSAASLKSLLKNPRL---LLGGLAIFLYVGAEGAIgdwLPLYLKDVLGLSEATAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 251 LPIPAAFFGAWFAGRPNKRF---PTLMWQSVICCLLAGVLMWIPGLlgvmtvWTLLVPAALFFFGAGMLFPLATSGAMEP 327
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFgpvRLLRLSALLAAVGLLLALLAPGP------WLALIGLALVGLGLSLMFPTIFSLALDG 327
|
330 340
....*....|....*....|....*.
gi 490208724 328 FPFLAGTAGALVGGLQNIGSGVLAWL 353
Cdd:COG0738 328 LGKRTAAAVSAVLIMGIVGGAIGPPL 353
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
25-183 |
6.14e-07 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 51.27 E-value: 6.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 25 TIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASA 104
Cdd:PRK10504 27 TIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490208724 105 LQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRacFVFLLILCAGVTFSMARWM 183
Cdd:PRK10504 107 LQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWH--WIFLINIPVGIIGAIATLM 183
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
22-329 |
1.37e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.91 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYlltyGVSQLFY----GPLSDRVGRR-PVILVGMSIFMLATLIAITTHSl 96
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAY----GISQMLLriplGILSDRIGKRkLFIIIGLLFTVLASLIMILFPS- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 97 PVLIAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRacFVFLLILCAGVT 176
Cdd:cd17490 85 PWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMR--APFLLAALAGVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 177 -FSMARWMPETRPTGAPRTRLITNYKTLFGTGafncyLLMLIGGLAGIAVFEACSGV-----LMGAVLGLSSMSVSILFI 250
Cdd:cd17490 163 gFILSLFIKEERREKKPVLTELKELLSVLKDK-----KLLFFSLLAILQQMITFSTTfgftpLIAKQLGASSFQLGLLSI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 251 LPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGV-LMWIPGllgVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP 329
Cdd:cd17490 238 IYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAyCFLIPF---APNLTLLYLLQALNGFGTGILFPLLMSLSIEGVP 314
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-317 |
2.21e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 20 GQMAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFM-----LATLIAITTH 94
Cdd:cd06173 11 SALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAllaavLALLALLGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 95 SLPVLIAASALQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACF---VFLLIL 171
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFainALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 172 CAGVTFSMARWMPETRPTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAG--IAVFEACSGVLMGAVLGLSSMSVSILF 249
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAllGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490208724 250 ILPIPAAFFGAWFAGRPNKRFPTLMWqSVICCLLAGVLMWIpglLGVMTVWTLLVPAALFFFGAGMLF 317
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRL-LLIGALLLGLALLV---LGLSPSLWLLLAALFLLGLAGGLF 314
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-351 |
3.65e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.72 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYeGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMAR 181
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPETR------PTGAPRTRLITNYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAvlglSSMSVSILFILPIPA 255
Cdd:COG2807 191 LLRRRPaaaaaaPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAAT----AGLLLSLFQLAGIPG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 256 AFFGAWFAGRPNKRFPTLMWQSVICCLLAGVLMWIPGllgvmtvWTLLVPAALFFFGAGMLFPLATSGAMEPFPfLAGTA 335
Cdd:COG2807 267 SLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG-------SLPWLWAVLLGLGQGGLFPLALTLIGLRAR-TPAEA 338
|
330
....*....|....*.
gi 490208724 336 GALVGGLQNIGSGVLA 351
Cdd:COG2807 339 AALSGMAQSVGYLLAA 354
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-357 |
1.70e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 37 SLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVM 116
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 117 ARTL----PRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVtfsmarwmpetrptgap 192
Cdd:cd17316 110 ASTYvaefAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLA----------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 193 rtrLITNYKTLFGTGaFNCYLLMLIGGLAGIAVfeacsgVLMGAVLGLSSMSVSILFILPIPAAFFGAWFAGRPNKRFPT 272
Cdd:cd17316 173 ---LLLRRRTLLLIL-LWFFISFGYYGLTTFLP------TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 273 LmWQSVICCLLAGVLMWIPGLLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSGVLA 351
Cdd:cd17316 243 K-KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLSYNLGRLGGGGAP 321
|
....*.
gi 490208724 352 WLSAMM 357
Cdd:cd17316 322 PLIALL 327
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
48-187 |
2.79e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 48 VMAAYLLTYGVSQLFYGPLSDRVGRR--PVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLY 125
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490208724 126 EGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPETR 187
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
146-317 |
4.98e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.14 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 146 LLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPETRPTGAPRTR--LITNYKTLFGT--------------GAF 209
Cdd:COG2270 168 FLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPRgaVRAGFRELRRTlrelrryrdllrflLAY 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 210 NCYllmlIGGLAGIAVFeacSGVLMGAVLGLSSMSVSILFILPIPAAFFGAWFAGRPNKRFPTLMwqsvicCLLAGVLMW 289
Cdd:COG2270 248 FFY----RDGVQTVIAF---AGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKR------VILVSLVIW 314
|
170 180
....*....|....*....|....*...
gi 490208724 290 IpgllgVMTVWTLLVPAALFFFGAGMLF 317
Cdd:COG2270 315 I-----VVCLAAYFLTTALAFWILGLLI 337
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-171 |
1.80e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 48 VMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEG 127
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 490208724 128 AQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLIL 171
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-356 |
3.09e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.36 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 48 VMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEG 127
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 128 AQLRHANSLLNMGILVS-PLLAPLIGGILDTLWNWRACFVFLLILCAGVTF----------------SMARWMPETRPTG 190
Cdd:TIGR00881 115 SERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLicflllrdspqscglpPAEEMPNEEPDGD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 191 APRTRLITNYKTLFGTGAFNCYLLMLIGgLAGIAVFEACSGVL------MGAVLGLSSMSVSILFILPIPAAFFGAWFAG 264
Cdd:TIGR00881 195 AEKKEEELTKKQIFLQYVLLNKVLWYIS-LGYVFVYVVRTGILdwsplyLTQEKGFSKEKASWAFTLYELGGLVGTLLAG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 265 ------RPNKRFPTLMWQSVICCLLAGVLMWIPGLLGVMTVWTLLVpAALFFFGAGMLFPLATSGAMepFPFLAGTAGAL 338
Cdd:TIGR00881 274 wlsdklFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFA-LGFLVYGPQMLIGVIASELA--PKKAAGTAAGF 350
|
330
....*....|....*...
gi 490208724 339 VGGLQNIGSGVLAWLSAM 356
Cdd:TIGR00881 351 VGFFAYLGGILAGLPLGY 368
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
47-185 |
3.40e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.34 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 47 SVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDlYE 126
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE-YA 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 127 GAQLR-HANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMARWMPE 185
Cdd:TIGR00895 135 PKRFRgTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPE 194
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-318 |
7.28e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAvqSVMAAYLL-TYGVSQLFYGP----LSDRVGRRPVILVGMSIFMLATLIAITTHSL 96
Cdd:cd17330 10 LGFGIVFPVLPFYVREFNKLGAS--GYYVGLLQsSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 97 PVLIAASALQgMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVT 176
Cdd:cd17330 88 WLLFLARFLD-GLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 177 FSMARWMPETRPTGaprtrlitnyktlfgtgafncyLLMLIGGLAGIAvFEACSGVLMGAVLGLSSMSVSILFIL-PIPA 255
Cdd:cd17330 167 VLVLFFLPPLRRLL----------------------LVYFLIALAFAG-LESVFSLFLKDRFGFSPSQIGLLLALvGIAG 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490208724 256 AFFGAWFAGRPNKRFPTlmwqsvICCLLAGVLMWIPGLLGVMTVWT---LLVPAALFFFGAGMLFP 318
Cdd:cd17330 224 ILAQLLLIPRLAKRLGE------RKLLRLGLLLAIIGLLLLPFASSvplLVLAAAILAFGTGIVFP 283
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
23-193 |
7.36e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.49 E-value: 7.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 23 AQTIYIPAIADMAVSLnvreGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAA 102
Cdd:cd17355 22 FGVFIIPIIAEFGWSR----AVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 103 SALQGMGTGVGGVMAR--TLPRDLYEGAQLRHANSLLNMGILVSPLLAPLIGGILDTlWNWRACFVFLLILCAGVTFSMA 180
Cdd:cd17355 98 WGLLGGGGAGTLAAVAfaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEA-FGWRTALLVLALLALLVLVPVL 176
|
170
....*....|...
gi 490208724 181 RWMPETRPTGAPR 193
Cdd:cd17355 177 LLLRRRPADLALR 189
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
30-355 |
8.64e-04 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 41.15 E-value: 8.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 30 AIADMAVSLNVREGAVQ-SVMA----AYLLTYGVSQLFYGPLSDRVGRRPVI-----LVGMSIFMLATLIAITTHSLP-V 98
Cdd:TIGR00900 16 AITQVALPLYVLAGTGSaSVLSlaalAGMLPYVVLSPIAGALADRYDRKKVMigadlIRAVLVAVLPFVALLGGLNIWqV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 99 LIAASALQGMGTGVGGVMARTLPRDLYEgAQLRHANSLLNMGILVSPLLAPLIGGILDTLW--NWRACFVFLLILCAGVT 176
Cdd:TIGR00900 96 YVLAGILAIAQAFFTPAYQAMLPDLVPE-EQLTQANSLSQAVRSLFYIVGPGIGGLMYATLgiKWAIWVDAVGFAISALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 177 FSMARWMPETRPTGAPRT-----------RLITNYKTLFGTGAFNcyllmLIGGLAGIAVFEACSGVLMGAVLGLSSMSV 245
Cdd:TIGR00900 175 IVSVRIPELAASEIQALSnavlrdtregiKFVLKNPLLRTLLLLA-----LLFNLVFAPAIVALFPYVQSKYLGRGSTHY 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 246 SILFILPIPAAFFGAWFAGRPNKRFPTLMWQSvICCLLAGVLMWIPGLLGVMtVWTLLVPAALFFFGAGMLFP-----LA 320
Cdd:TIGR00900 250 GWVLAAFGLGALLGALLLGLLGRYFKRMALMT-GAIFVIGLAILVVGLTPPN-FPLFLVLWFAIGVGYGPINVpqgtlLQ 327
|
330 340 350
....*....|....*....|....*....|....*
gi 490208724 321 TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSA 355
Cdd:TIGR00900 328 RRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLAD 362
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
61-355 |
1.33e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.38 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 61 LFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEGAQ---LRHANSLL 137
Cdd:cd17333 49 LLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSatrLNVLHGFF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 138 NMGILVSPLLAPLIGGILDTlWNWRACFVFLLILCAGVTFSMARWMPetRPTGAPRTRLITNYKTLFGTGAFNCYLLML- 216
Cdd:cd17333 129 GLGALIGPLIATSLLTSELS-WSWAYLIIGLIYLLLAILILLTLFPE--LPSARNPQQSVGAFSASASRLLRNPSIILGa 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 217 IGGLAGIAVFEACSGVLMGAVLGLSSMSVSILFIlpIPAAFFGAWFAGR----PNKRFPTLMWQSVICCLLAGVLMWIpg 292
Cdd:cd17333 206 LALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGY--LLSGFWVGITIGRllggPISRRIKPHTLLVLSGSGALLGLLI-- 281
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490208724 293 LLGVMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSA 355
Cdd:cd17333 282 LLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
22-353 |
5.63e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 22 MAQTIYIPAIADMAVSLNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIA 101
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 102 ASALQGMGTGVGGVMARTLPRDLYEGAQLRhANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLILCAGVTFSMAR 181
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGGRRGL-AMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 182 WMPETRPTGAPRTRLITNYKTLFGTgAFNCYLLMLIGGL-----AGIAVFEACSGVLMGAVLGLSSMSVSILFILPIPAA 256
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARSTLKGV-WRALLLLLIIVFLrswvlSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 257 FFGAWFAGRPNKRfpTLMWQSVICCLLAGVLMWIPGLlgvmtVWTLLVpAALFFFGAGMLFPLATSGAMEPFPFLAGTAG 336
Cdd:cd17478 248 LIGGPLSDRFGRR--RVIIASLLLAAPFLLLFLLTPG-----IWSYIL-LVLAGFLLFASFPVTVVLAQELLPGNVGLAS 319
|
330
....*....|....*..
gi 490208724 337 ALVGGLQNIGSGVLAWL 353
Cdd:cd17478 320 GLMMGLSFGLGGIGAPV 336
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
57-182 |
6.12e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.88 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 57 GVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALqgmgTGVGGVMARTLPrdLYEGAQLRHANSL 136
Cdd:pfam06609 92 AVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTL----LGVAAGPAGASP--LFIGELMSNKTKF 165
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490208724 137 LNMGILVSPLLA-----PLIGGILDTLWNWRACFVFLLILCAGVTFSMARW 182
Cdd:pfam06609 166 LGLLIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIW 216
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
48-171 |
1.00e-02 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 37.57 E-value: 1.00e-02
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490208724 48 VMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMLATLIAITTHSLPVLIAASALQGMGTGVGGVMARTLPRDLYEG 127
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPA 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 490208724 128 AQLRHANSLLNMGILVSPLLAPLIGGILDTLWNWRACFVFLLIL 171
Cdd:cd17365 119 RRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
|
| |
