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Conserved domains on  [gi|490214710|ref|WP_004113093|]
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MULTISPECIES: DUF1471 domain-containing protein [Enterobacteriaceae]

Protein Classification

DUF1471 domain-containing protein( domain architecture ID 10538310)

DUF1471 domain-containing protein similar to Escherichia coli multiple stress resistance protein BhsA, which may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 33-89 1.51e-16

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


:

Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 66.78  E-value: 1.51e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490214710  33 LTHVGSISVGpsgGQFSSPSDLHDQLSKLADEKGGKFYVITAAREHGP-NFEATAEVY 89
Cdd:pfam07338  1 LQPIGTVSVS---GVFGSPSDAEAALSKKADAKGAKSYRIISADEPNGgNWHGTAELY 55
 
Name Accession Description Interval E-value
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 33-89 1.51e-16

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 66.78  E-value: 1.51e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490214710  33 LTHVGSISVGpsgGQFSSPSDLHDQLSKLADEKGGKFYVITAAREHGP-NFEATAEVY 89
Cdd:pfam07338  1 LQPIGTVSVS---GVFGSPSDAEAALSKKADAKGAKSYRIISADEPNGgNWHGTAELY 55
ydgH_STM1478 NF040471
DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with ...
 46-90 2.21e-05

DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with three tandem copies of the DUF1471 domain instead of just one. Note that STM1478 from the Salmonella enterica model strain LT2 is also called SssB.


Pssm-ID: 439699 [Multi-domain]  Cd Length: 317  Bit Score: 40.85  E-value: 2.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 490214710  46 GQFSSPSDLHDQLSKLADEKGGKFYVITAA-REHGPNFEATAEVYK 90
Cdd:NF040471 272 GHFSSMTDVSYQVAKRAAKKGAKYYHITRQwQSNGGNLTISADLFK 317
 
Name Accession Description Interval E-value
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 33-89 1.51e-16

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 66.78  E-value: 1.51e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490214710  33 LTHVGSISVGpsgGQFSSPSDLHDQLSKLADEKGGKFYVITAAREHGP-NFEATAEVY 89
Cdd:pfam07338  1 LQPIGTVSVS---GVFGSPSDAEAALSKKADAKGAKSYRIISADEPNGgNWHGTAELY 55
ydgH_STM1478 NF040471
DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with ...
 46-90 2.21e-05

DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with three tandem copies of the DUF1471 domain instead of just one. Note that STM1478 from the Salmonella enterica model strain LT2 is also called SssB.


Pssm-ID: 439699 [Multi-domain]  Cd Length: 317  Bit Score: 40.85  E-value: 2.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 490214710  46 GQFSSPSDLHDQLSKLADEKGGKFYVITAA-REHGPNFEATAEVYK 90
Cdd:NF040471 272 GHFSSMTDVSYQVAKRAAKKGAKYYHITRQwQSNGGNLTISADLFK 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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