NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|490226929|ref|WP_004125281|]
View 

MULTISPECIES: putative quinol monooxygenase [Klebsiella]

Protein Classification

putative quinol monooxygenase( domain architecture ID 10003583)

monooxygenase similar to Escherichia coli quinol monooxygenase YgiN that can oxidize menadiol to menadione, may be an antibiotic biosynthesis monooxygenase involved in the biosynthesis of antibiotics, such as Streptomyces tetracenomycin-F1 monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  16496224
SCOP:  4000637

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-101 2.46e-20

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 78.07  E-value: 2.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490226929   2 LTVIAEIRTRPGqhHRQAVLDQFAKITPTVLQEEGCHGYAPLVDhaagvsfqTTSPDSIVMVEQWESVAHLEAHLQTPHM 81
Cdd:COG1359    1 ITVIAKLTVKPG--KRDEFLAALRELVEATRAEPGCLSYELYRD--------PDDPNRFVLYERWEDEAALEAHLASPHF 70

                         90       100
                 ....*....|....*....|.
gi 490226929  82 KAYGEAVKGDVLE-MNIRILE 101
Cdd:COG1359   71 KAFLAALAPLLAEpPEVRVYE 91
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-101 2.46e-20

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 78.07  E-value: 2.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490226929   2 LTVIAEIRTRPGqhHRQAVLDQFAKITPTVLQEEGCHGYAPLVDhaagvsfqTTSPDSIVMVEQWESVAHLEAHLQTPHM 81
Cdd:COG1359    1 ITVIAKLTVKPG--KRDEFLAALRELVEATRAEPGCLSYELYRD--------PDDPNRFVLYERWEDEAALEAHLASPHF 70

                         90       100
                 ....*....|....*....|.
gi 490226929  82 KAYGEAVKGDVLE-MNIRILE 101
Cdd:COG1359   71 KAFLAALAPLLAEpPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-84 2.02e-16

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 67.29  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490226929    2 LTVIAEIRTRPGqhHRQAVLDQFAKITPTVLQEEGCHGYAPLVDhaagvsfqTTSPDSIVMVEQWESVAHLEAHLQTPHM 81
Cdd:pfam03992   1 IVVVAEIRVKPG--KAEEFEEALAELVEATRNEPGCLSYELLRS--------LEDPDEYVVLEVWEDEAAFEAHLQSPHF 70


                  ...
gi 490226929   82 KAY 84
Cdd:pfam03992  71 KAA 73
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-101 2.46e-20

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 78.07  E-value: 2.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490226929   2 LTVIAEIRTRPGqhHRQAVLDQFAKITPTVLQEEGCHGYAPLVDhaagvsfqTTSPDSIVMVEQWESVAHLEAHLQTPHM 81
Cdd:COG1359    1 ITVIAKLTVKPG--KRDEFLAALRELVEATRAEPGCLSYELYRD--------PDDPNRFVLYERWEDEAALEAHLASPHF 70

                         90       100
                 ....*....|....*....|.
gi 490226929  82 KAYGEAVKGDVLE-MNIRILE 101
Cdd:COG1359   71 KAFLAALAPLLAEpPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-84 2.02e-16

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 67.29  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490226929    2 LTVIAEIRTRPGqhHRQAVLDQFAKITPTVLQEEGCHGYAPLVDhaagvsfqTTSPDSIVMVEQWESVAHLEAHLQTPHM 81
Cdd:pfam03992   1 IVVVAEIRVKPG--KAEEFEEALAELVEATRNEPGCLSYELLRS--------LEDPDEYVVLEVWEDEAAFEAHLQSPHF 70


                  ...
gi 490226929   82 KAY 84
Cdd:pfam03992  71 KAA 73
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-83 2.25e-03

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 34.58  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490226929   1 MLTVIAEIRTRPGqhHRQAVLDQFAKITPTVLQEEGCHGYAPLVDhaagvsfqTTSPDSIVMVEQWESVAHLEAHLQTPH 80
Cdd:COG2329    1 MIVVINRFRVKPG--QEEEFEEAFAERRELLAEQPGFLGFELLRS--------LEDPGEYLVVSYWESEEAFRAWFRSSE 70


                 ...
gi 490226929  81 MKA 83
Cdd:COG2329   71 HRA 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH