|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-426 |
5.47e-81 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 254.03 E-value: 5.47e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 25 LMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISC 104
Cdd:cd17319 4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 105 GMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHGWQ 184
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPP------LSGWLLLLFGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 185 WMFFIEGLPAIALAFVVWRRLpdkpadarwldshdvqaitavlekeaeetrhtpsrfslktalttRVFLLLVLIYFTHQF 264
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYL--------------------------------------------RQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 265 SVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFA--RTEQRSRSMLMAGYLVMATGMAIGAIAGH-GV 341
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSdrLLRGARRLVIIIGLLLAAVGLLLAYLTTSpVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 342 ALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGAL 421
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
....*
gi 490236148 422 ASLLI 426
Cdd:cd17319 354 LVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
31-426 |
1.04e-66 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 218.36 E-value: 1.04e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 31 VAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVT 110
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 111 GPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllsldgMSGW----HGWQWM 186
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGP----------LVGWilihFSWQWA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 187 FFIEGLPAIALAFVVWRRLPDKPADARWLDShDVQAIT--AVLEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQF 264
Cdd:TIGR00893 151 FIIEGVLGIIWGVLWLKFIPDPPQKAKWLTE-EEKYIVvgGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 265 SVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSR-----SMLMAGYLVMATGMAIGAIAGH 339
Cdd:TIGR00893 230 GLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGkslvfARKTAIIAGLVLSLLMFATNYV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 340 GVALLGFSLAAFMFFAMQSIIFNW--LPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLI 417
Cdd:TIGR00893 310 NIPYAALALVALGFFGLGAGAIGWalISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALAL 389
|
....*....
gi 490236148 418 VGALASLLI 426
Cdd:TIGR00893 390 IGALSYLLL 398
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
20-371 |
5.21e-54 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 185.53 E-value: 5.21e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 20 KIYRHLMPLLIVAYIISFIDRTNIGMAK-ATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMIT 98
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 99 WGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGGLLLSLDGMS 178
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 179 GWHGWQWMFFIEGLPAIALAFVVWRRLPDKPADARWLDSHDVQAITAVLEKEAEETRHTPSRFS-LKTALTTRVFLLLVL 257
Cdd:cd17327 161 GLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKqIKEAFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 258 IYFTHQFSVYGLSYFLPGIIGSWGQLTpLQIGLLTAIPWIAAAAGGIL-LPRFARTEQRSRSMLMAGYLVMATGMAIGAI 336
Cdd:cd17327 241 FFFCSQITNNGISNFLPLILKSLGFYS-LQTNLLSVPIGALGAVSLLIaALLSDRFKKRGLFAIFACVLALVGSIILLAA 319
|
330 340 350
....*....|....*....|....*....|....*
gi 490236148 337 AGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSGH 371
Cdd:cd17327 320 PNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGY 354
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-427 |
5.76e-53 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 181.22 E-value: 5.76e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 15 QRTHKKIYRHLMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIAR 94
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 95 IMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSL 174
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP------LL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 175 DGMSGWHGWQWMFFIEGLPAIALAFVvwrrlpdkpadarwldshdvqaitavlekeaeetrhtpsrfslktalttrVFLL 254
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALL--------------------------------------------------RFWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 255 LVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFA-RTEQRSRSMLMAGYLVMATGMAI 333
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdRLGRRRKLVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 334 GAIAGHG-VALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGaATSGLWFA 412
Cdd:COG2271 265 LALLPSPaLAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLL 343
|
410
....*....|....*
gi 490236148 413 VALLIVGALASLLIK 427
Cdd:COG2271 344 AALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-427 |
1.18e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 160.05 E-value: 1.18e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 27 PLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGM 106
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 107 AFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHGWQWM 186
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAF------LAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 187 FFIEGLPAIALAFVVWRRLPDKPADARwldshdvqaitavlekeaeeTRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSV 266
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAA--------------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 267 YGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMlMAGYLVMATGMAIGAIAGHGVALLGF 346
Cdd:COG2223 222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL-LIVFALMALGLLLLALALGSLWLFLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 347 SLAAFMFF--AMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALASL 424
Cdd:COG2223 301 LFLLLGLAlgGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
...
gi 490236148 425 LIK 427
Cdd:COG2223 381 LLY 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-424 |
7.14e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 113.68 E-value: 7.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 29 LIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAF 108
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 109 VTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglLLSLDGMSGWHGWQWMFF 188
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPL----LGGILASSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 189 IEGLPAIALAFVVWRRLPDKPADARwldshdvqaitavleKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYG 268
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESAR---------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 269 LSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMATGMAIGAIAG-HGVALLGFS 347
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPsLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490236148 348 LAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALASL 424
Cdd:cd06174 302 LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-388 |
2.74e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 105.83 E-value: 2.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 23 RHLMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGII 102
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 103 SCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLgglllsLDGMSGWHG 182
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL------GGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 183 WQWMFFIEGLPAIALAFVVWRRLPdkpadarwldshdvqaitavlekEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTH 262
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLP-----------------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 263 QFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRsRSMLMAGYLVMATGMAIGAIAGHGVA 342
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR-RRLLLIGLLLLALGLLLLALAGSLWL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490236148 343 LL-GFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGG 388
Cdd:COG2814 299 LLlALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-392 |
9.64e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.34 E-value: 9.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 29 LIVAYIISFIDRTNIGMA-KATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMA 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 108 FVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLgglllsLDGMSGWHGWQWMF 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLL------GGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 188 FIEGLPAIALAFVVWRRLPDKPAdarwldshdvqaitavlEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVY 267
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPES-----------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 268 GLSYFLPGIIGSWGqLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMATGMAIGAIAG---HGVALL 344
Cdd:pfam07690 218 GLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlsSLWLLL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490236148 345 GFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGP 392
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
49-426 |
1.93e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 95.71 E-value: 1.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 49 TMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAG 128
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 129 LYPGIIYYLTLWFGREeRAKATGLFLLGVCLANIIGAplggllLSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDK 208
Cdd:COG2807 123 GNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAA------GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 209 PADARwldshdvqaitavlekeaeetrHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQI 288
Cdd:COG2807 196 PAAAA----------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG-LSAATA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 289 GLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFMFFAMQSIIFNWLPSIM 368
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490236148 369 SGHMLAGS-FGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALASLLI 426
Cdd:COG2807 333 RTPAEAAAlSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
50-426 |
2.35e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 77.31 E-value: 2.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 50 MSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYV-MRLLLGAAEAG 128
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLlWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 129 LYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLgglllsLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDK 208
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPL------GAALIEAFGWRTALLVLALLALLVLVPVLLLLRRR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 209 PADArwldshdvqaitavLEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQI 288
Cdd:cd17355 183 PADL--------------ALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG-ISPAAA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 289 GLLTAIPWIAAAAGGILLPRFARteqRSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFMF----FAMQSIIFNWL 364
Cdd:cd17355 248 AVALALIGLFNIVGRLLSGWLGD---RYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFglgwGATVPLTAALA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490236148 365 PSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALASLLI 426
Cdd:cd17355 325 ARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
33-406 |
3.33e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 76.65 E-value: 3.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 33 YIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGP 112
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 113 TSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGGLLLSLDGmsgwhGWQWMFFIEGL 192
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY-----SWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 193 PAIALAFVVWRRLPDKPADARWLDSHDVQAITAVLEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFThqfsVYGLSYF 272
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVF----VYVVRTG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 273 lpgiIGSWGQL--------TPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAgyLVMATGMAIGAI-----AGH 339
Cdd:TIGR00881 235 ----ILDWSPLyltqekgfSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLA--VFFMALIIVSLLvywlnPAA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490236148 340 GVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHM-LAG-SFGLLNCLGLCGGFLGPFILGAFEDRTGAAT 406
Cdd:TIGR00881 309 NPLMDLICLFALGFLVYGPQMLIGVIASELAPKkAAGtAAGFVGFFAYLGGILAGLPLGYLADGFGWAG 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-427 |
6.03e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.08 E-value: 6.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 53 DIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPG 132
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 133 IIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDKPAda 212
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPL------LGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 213 rwldshdvqaitavlEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLT 292
Cdd:cd17325 177 ---------------PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 293 AIPWIAAAAGGILLPRFARTEQRsRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHM 372
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490236148 373 LAG-SFGLLNCLGLCGGFLGPFILGAFEDRTGAATSgLWFAVALLIVGALASLLIK 427
Cdd:cd17325 321 GRGtAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP-FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-424 |
1.44e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.89 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 50 MSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGL 129
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 130 YPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDKP 209
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRP------LGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 210 ADARwldshdvqaitavlekeaeetRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIG 289
Cdd:cd17324 179 PKKP---------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 290 LLTAIPWIAAAAGGILLPRFARTEQRsRSMLMAGYLVMATGMAIGAIAGHG-VALLGFSLAAFMFFAMQSIIFNWLpSIM 368
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGR-RALLIALLLLAAALLLLTLLGPSPlLLLVGLVLWGLGFFAAHSALQTRV-LRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490236148 369 SGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAAtSGLWFAVALLIVGALASL 424
Cdd:cd17324 316 APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA-GVGWVGAALLLLALLLAL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-425 |
1.15e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.27 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 53 DIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPG 132
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 133 IIYYLTLWFGREERAKATGLFLLGVCLANIIGAplggllLSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDKPAda 212
Cdd:cd17475 105 GGRAIMRWFPPRERGLAMGIRQTGVPLGGALAA------ALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 213 rwldshdvqaitAVLEKEAEETRHTpsrfSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLT 292
Cdd:cd17475 177 ------------ASAATESASTLLR----SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 293 AIPWIAAAAGGILLPRFA---RTEQRSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFM-FFAM--QSIIFNWLPS 366
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSdrvFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLgLFAIgwNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490236148 367 IMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGlWFAVALLIVGALASLL 425
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPA-WLALALLLVLAALLLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
85-425 |
1.15e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 85 RIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIg 164
Cdd:cd17473 61 RFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVV- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 165 aplgglllsLDGMSGW---HGWQWMFFIEGLpAIALAFVVWRRLPdkpadarwldshdvqaitavlEKEAEETRHTPSRF 241
Cdd:cd17473 140 ---------FLLLGGAlaeIGWRAPFLVYLL-ALPVLILVLLFLP---------------------EPARKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 242 SLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEqRSRSMLM 321
Cdd:cd17473 189 ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL-GKRRLLA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 322 AGYLVMATGMAIGAIA-GHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFED 400
Cdd:cd17473 268 IGFALMALGFLLLALAsGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVN 347
|
330 340
....*....|....*....|....*
gi 490236148 401 RTGAATSGLWFAVALLIVGALASLL 425
Cdd:cd17473 348 LTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-427 |
1.95e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.42 E-value: 1.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 19 KKIYRHLMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMIT 98
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 99 WGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAK---ATGLFLLGVCLANIIGAPLGGLLLSLd 175
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRlnlLHAFFSLGALLGPLLGGLLILLGLSL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 176 gmsgwhGWQWMFFIEGLPAIALAFVVWR-RLPdkpadarwldshdvqaitavlEKEAEETRHTPSRFSLKTALTTRVFLL 254
Cdd:COG0738 162 ------SWHLPYLILAVLLLLLALLFLRsKLP---------------------EIEEEEEEAAGSAASLKSLLKNPRLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 255 LVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTeqRSRSMLMAGYLVMATGMAIG 334
Cdd:COG0738 215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR--FGPVRLLRLSALLAAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 335 AIAGHG--VALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGsFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFA 412
Cdd:COG0738 293 ALLAPGpwLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAA-VSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371
|
410
....*....|....*
gi 490236148 413 VALLIVGALASLLIK 427
Cdd:COG0738 372 VCYLLILLLALALKR 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
85-424 |
4.63e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 69.94 E-value: 4.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 85 RIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIG 164
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 165 AplGGLLLSLDGMSGWHGWQWMFFIEGLPAIaLAFVVWRRLpdkpadarwldshdvqaitavlekeaeetrhtpsrfslk 244
Cdd:cd17316 142 A--LVASLLIPLLSGDWGWRILFLIGALPAL-LALLLRRRT--------------------------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 245 talttrvfLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSML--MA 322
Cdd:cd17316 180 --------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVigLI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 323 GYLVMATGMAIGAIAGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRT 402
Cdd:cd17316 252 LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
330 340
....*....|....*....|..
gi 490236148 403 GAATSGLWFAVALLIVGALASL 424
Cdd:cd17316 332 GGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-425 |
6.89e-11 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 63.34 E-value: 6.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 26 MPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCG 105
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 106 MAFVTGPT--SFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAplggllLSLDGMSGWHGW 183
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGG------LIGPLLLEYYGW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 184 QWMFFIEGLPAIALAFVVWRRLPDkpadarwldshdvqaitavlekeaeetrhtpsrfslktalttrvFLLLVLIYFTHQ 263
Cdd:cd17380 155 PSVFYFFGLLGLLWALVWLIYLPP--------------------------------------------VWAIIVAHFCMN 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 264 FSVYGLSYFLPgiigSWGQ--LTPLQ-IGLLTAIPWIAAAAGGILLPRFArteqrsRSMLMAGYLVMATGMAIGAIA--G 338
Cdd:cd17380 191 WGFYILLSWLP----TYFHevLVPLAkGWVFNVVPWLVMFPSSNVAGWLA------DHLISRGWTVTSVRKLMQSIGflG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 339 HGVALLGFSLA-------AFMFFAMQSIIFNWlpsimSGHML---------AGS-FGLLNCLGLCGGFLGPFILGAFEDR 401
Cdd:cd17380 261 PALFLLLLSHTdsfslalLCMSVALGLSAFSS-----SGVLVnhqdiapnyAGIvFGISNTAGTIPGIVGVYLTGYILEA 335
|
410 420
....*....|....*....|....
gi 490236148 402 TGAATSGLWFAVALLIVGALASLL 425
Cdd:cd17380 336 TGSWSLVFVLAAVVNLVGAVVFLL 359
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
23-396 |
9.34e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.14 E-value: 9.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 23 RHLMPLLIVAYIISFIDRTN---IGMAKATMSVDIGL---------SATAFGLGAGLFFLTYavleipsnlFLTRIGARR 90
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDlaaMGFAAPAISAEWGLdpvqlgflfSAGLIGMAFGALFFGP---------LADRIGRRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 91 WIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAplggl 170
Cdd:TIGR00895 84 VLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGG----- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 171 llsldGMSGW----HGWQWMFFIEGLPAIALAFVVWRRLPD--------KPADARW-----LDSHDVQAITAVLEKEAEE 233
Cdd:TIGR00895 159 -----FLAGWlipvFGWRSLFYVGGIAPLLLLLLLMRFLPEsidflvskRPETVRRivnaiAPQMQAEAQSALPEQKSTQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 234 TRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPG-IIGSWGQLTplQIGLLTAIPWIAAAAGGILLPRFArt 312
Cdd:TIGR00895 234 GTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKlMVELGFSLS--LAATGGALFNFGGVIGSIIFGWLA-- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 313 EQRSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFMFFA--MQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFL 390
Cdd:TIGR00895 310 DRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVngGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAII 389
|
....*.
gi 490236148 391 GPFILG 396
Cdd:TIGR00895 390 GPILAG 395
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-310 |
2.18e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.37 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 12 TQLQRTHKKIYRHLMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRW 91
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 92 IARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAplggll 171
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 172 LSLDGMSGWHGWQWMFFIeGLPAIALAFVVWRRLPDKPADARWLDSHDVQAITAVLEKEAEETRHTPSRFSLKTALTTRV 251
Cdd:COG0477 156 LLGGLLVAALGWRWIFLI-NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 490236148 252 FLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFA 310
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-425 |
3.40e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 28 LLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMA 107
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 108 FVTGPTSF-----YVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGGLllsldgMSGWHG 182
Cdd:cd06173 83 LLALLGSLslwllLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGL------LVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 183 WQWMFFIEGLPAIALAFVVWRRLPDKPADARwldshdvqaitavlekEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTH 262
Cdd:cd06173 157 PGGAFAINALSFLLSALLLLFIRRPPPAAPG----------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 263 QFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMATGMAIGAIAGHGVA 342
Cdd:cd06173 221 ALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 343 LLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALA 422
Cdd:cd06173 301 LAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
...
gi 490236148 423 SLL 425
Cdd:cd06173 381 LLL 383
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
23-209 |
1.83e-09 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 58.96 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 23 RHLMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGII 102
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 103 SCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVclaNIIGAplgGLLLSLDGMSGWHG 182
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSH---NIGGA---LIPILTGFAALTYG 155
|
170 180
....*....|....*....|....*..
gi 490236148 183 WQWMFFIEGLPAIALAFVVWRRLPDKP 209
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
27-415 |
4.65e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.02 E-value: 4.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 27 PLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGaRRWIARIMIT-WGIISCG 105
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILiWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 106 MAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGGLLLSLDGmsgwhGWQW 185
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 186 MFFIEGLPAIALAFVVWRRLPDKPADARWLDSHDVQAITAVLEkeaeetrhtpsrfSLKTALTTRVFLLLVLIYFTHQFS 265
Cdd:cd17328 156 AFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLA-------------DLKALAKNPSFILSTLGFTAVSFV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 266 VYGLSYFLPG---IIGSWGQLTPLQIGL-LTAIPWIAAAAG----GILLPRFARTEQRSRSMLMAGYLVMATGMAIGAIA 337
Cdd:cd17328 223 TGALAFWAPTfflRAFGVGDLSSADVGLiFGAITCIAGVLGvllgGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 338 GH----GVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLN-CLGLCGGFLGPFILGAFEDRTGAA-TSGLWF 411
Cdd:cd17328 303 LAlsnlLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIlLSHLLGDAGSPYLIGLISDLLRQNkDSPLAE 382
|
....
gi 490236148 412 AVAL 415
Cdd:cd17328 383 AASL 386
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
28-209 |
1.02e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 56.90 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 28 LLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMA 107
Cdd:cd17312 7 GVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 108 FVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGGLLLsldgmsGWHGWQWMF 187
Cdd:cd17312 87 FSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYGWRAAF 160
|
170 180
....*....|....*....|..
gi 490236148 188 FIEGLPAIALAFVVWRRLPDKP 209
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP 182
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
30-422 |
1.17e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 56.49 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 30 IVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRW--IARIMITWGIISCgMA 107
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfiASLLLLLIPLLAL-AL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 108 FVTGPTSFYVMRLLLGAAEAGLYPGiIYYLTLWFGREERAKATGLFL----LGVCLANIIGAPLGGLLLSLDgmsGWHGW 183
Cdd:cd17341 84 AVSSYWGLLVLGFLLGFAGANFASG-QPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFDG---GFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 184 QWMFFIEGLPAIALAFVVW---RRLPDKPADARwldshdvqaitavlekeaeetrhtPSRFSLKTALTTRVFLLLVLIYF 260
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLlfgDDLPTGKASAL------------------------EFLKVQLAVLKNYRTWILSLLYG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 261 THQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAA----AGGILLPRFArteqrSRSMLMAGYLVMATGMAIGAI 336
Cdd:cd17341 216 VTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGAlarpAGGWLSDRFG-----GRRRLWWLFIVMTIGAALLSL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 337 AGH--GVALLGFSLAAFMFFAMQSIIFNWLPSI---MSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWF 411
Cdd:cd17341 291 SLPtsGTNLVLFLALFVALGLGAGAGNGSVFRMvpfIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSL 370
|
410
....*....|.
gi 490236148 412 AVALLIVGALA 422
Cdd:cd17341 371 FGVLAVACTLL 381
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
117-396 |
2.31e-08 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 55.90 E-value: 2.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 117 VMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGGLLLSLdgmsgWHGWQWMFFIEGLPAIA 196
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCES-----WGGWPMIFYVFGIVGCA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 197 LAFVVWRRLPDKPADARWLDSHDVQAITAVLEkeaEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGI 276
Cdd:TIGR00894 211 WSLLWFVFPADDPSIHPCISKFEKKYINSSLQ---GQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTF 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 277 IGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTeqrsrsMLMAGYLVM-ATGMAIGAIAGHGVALLGFSLAAFMFFA 355
Cdd:TIGR00894 288 ISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADF------LKSSKTLSLtAARKIFNGIGGLGPGIFAYALPYLSAAF 361
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 490236148 356 MQSIIFNWLPSIMSGHMLAGS-----------FGLLNCLGLCGGFLGPFILG 396
Cdd:TIGR00894 362 YLTIIILTLANAVSSGPLAGVlinsldlaprfLGFIKGITGLPGFIGGLIAS 413
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
31-209 |
4.12e-08 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 54.94 E-value: 4.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 31 VAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVT 110
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 111 GPTS----FYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFllgVCLANIIGAPLGGLLLSLDGMSGWHGWQWM 186
Cdd:cd17345 90 SATSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIW---NISHNVGGGLVGPLAGLGLAIFGDGWWRGA 166
|
170 180
....*....|....*....|...
gi 490236148 187 FFIEGLPAIALAFVVWRRLPDKP 209
Cdd:cd17345 167 FIFPAIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
50-425 |
6.57e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 54.23 E-value: 6.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 50 MSVDIGLSATAFGLGAGLFFLTYAVLEIpsnlfLTRIGARRWIARIMITWGIISC-----GMAFVTGPTSFYVMRLLLGA 124
Cdd:cd06180 25 MLAELGLSYAQAGWIATANYAGYLVGAL-----LASFLRRRGRARRLIRGGLLLTvlllaAMALTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 125 AEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGApLGGLLLSLDGMSGWHGWQWMffieGLPAIALAFVVWRR 204
Cdd:cd06180 100 ASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSG-LLVPAGLGGGLSWRAGWLAL----ALLSAVLLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 205 LPDKPADarwldshdvqaitavlekeaeetrHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLT 284
Cdd:cd06180 175 LRRGPSA------------------------PTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETG-AG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 285 PLQIGLLTAIPWIAAAAGGILLPRfARTEQRSRSMLMAGYLVMATGMAIgAIAGHGVALLGFS--LAAFMFFAMQSIIFN 362
Cdd:cd06180 230 SLLAGLLWSLFGLAAVPSCFLWGA-LSDRWGTRRALAANLLVQAVGVLL-PLLSPGPAGLVLSavLFGGTFMAITALVMA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490236148 363 wLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALASLL 425
Cdd:cd06180 308 -LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
12-209 |
1.04e-07 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 53.95 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 12 TQLQRTHKKIYRHLMPLLIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRW 91
Cdd:PRK11663 11 HEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 92 IARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAkatGLFLLGVCLANIIGAplgGLL 171
Cdd:PRK11663 91 MGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERG---GWWAIWNTAHNVGGA---LIP 164
|
170 180 190
....*....|....*....|....*....|....*...
gi 490236148 172 LSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDKP 209
Cdd:PRK11663 165 LVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKP 202
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
50-426 |
2.06e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 52.61 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 50 MSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTG-PTSFYVMRLLLGAAEAG 128
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISlPLLFLGYGVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 129 LYPGIIYYLTLWFgREERAKATGLFLLGVCLANIIGAPLGGLLLSLDgmsgwhGWQWMFFIEGLPAIALAFVVWRRLPDK 208
Cdd:cd17353 109 GYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTV------GVPTTFLILGIIFLIIIVIGAFLIRDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 209 PADarwldshDVQAITAVLEKEAEETrhtPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQI 288
Cdd:cd17353 182 PKG-------WVPPGVDPLANNAENS---PRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 289 GLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAgYLVMATGMAIGAIAGHGVAL--LGFSLAAFMFFAMQSIIFNWLPS 366
Cdd:cd17353 252 ALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIA-FLIQGVAMFLLPFIGSVAVLfvLGVALIGFCYGGGFALFPALTAD 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 367 IMSGHMLAGSFGLLNCLGLCGGFLGPFIlGAFEDRTGAATSGLWFAVALLIVGALASLLI 426
Cdd:cd17353 331 FFGTKNAGTNYGLLYTAKGVGGLIGPII-AAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
144-425 |
4.44e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 4.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 144 EERAKATGLFLLGVCLANIIGAPLGGLLLSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPdkpadarwldshdvqai 223
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK----------------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 224 tavlEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGG 303
Cdd:COG2211 206 ----ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 304 ILLPRFARTEQRsRSMLMAGYLVMATGMAIGAIAGHG---VALLGFSLAAFMFFAMQSIIFNWLPSIMSGH--------- 371
Cdd:COG2211 282 PLWPRLAKRFGK-KKAFIIGLLLAALGLLLLFFLGPGnlwLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrre 360
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 490236148 372 -MLAGSFGLLNCLGL-CGGFLGPFILGAFEDRTGAATSG---LWFAVALLIVGALASLL 425
Cdd:COG2211 361 gLYFGIFTFAIKLGQaLAGALAGLLLALFGYVAGAAQSPsalTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-427 |
4.97e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 4.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 29 LIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAF 108
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 109 VTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLGglllslDGMSGWHGWQWMFF 188
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLG------GLLLELFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 189 IeGLPAIALAFVVwrrlpdkpadarwldshdvqaitavlekeaeetrhtpsrfslktaltTRVFLLLVLIYFTHQFSVYG 268
Cdd:cd17321 155 I-NVPIGLVALLL-----------------------------------------------ARTFSGAVLAAFLLGAALGG 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 269 LSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQrSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSL 348
Cdd:cd17321 187 LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG-PRLVLVAGLLLTAVGLLLLALLGADSSVWLLLP 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 349 AAFMFFA----MQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAF----------------------EDRT 402
Cdd:cd17321 266 GLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALltaglsanlgdsgvaallsaaaAAFA 345
|
410 420
....*....|....*....|....*
gi 490236148 403 GAATSGLWFAVALLIVGALASLLIK 427
Cdd:cd17321 346 AGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-422 |
5.25e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.44 E-value: 5.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 53 DIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPG 132
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 133 IIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHGWQWMFFIEGLpAIALAFVVWRRLPDKPada 212
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPA------LGLFLYQHLGFAVLFIVAAV-LALLALLLVFLVKDPP--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 213 rwldshdvqaitAVLEKEAEETRHTPSRFSLKTALTTRVFLLLVliyfthQFSVYGLSYFLPgiigSWGQLTPL-QIGLL 291
Cdd:cd17489 175 ------------PVAAEEAEAGTRAFRRLVEKKVLPPALILFLA------SIAYGAISTFLP----LYAAERGIsNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 292 TAIPWIAAAAGGILLPRFARTEQRSRsMLMAGYLVMATGM-AIGAIAGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSG 370
Cdd:cd17489 233 FTVYAIALLLSRPFSGKLSDRKGPKT-VIIPGLLLLALGLlLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490236148 371 HMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGaaTSGLWFAVALLIVGALA 422
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVVVLLALV 361
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
34-426 |
7.32e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 7.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 34 IISFIDRTNIGMAKATMSV----DIGLSATAfglgAGLFFLTYAVLEIPSNLF---LT-RIGARRWIARIMITWGIISCG 105
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIylhqQLGLSASI----VGLVLALSAVAGIVASLIggrLAdRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 106 MAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAplgglllsldGMSGW---HG 182
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGP----------LLGGLlllYS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 183 WQWMFFIEGLPAIALAFVVWRRLPDKPADARwldshdvqaitavlekeaeETRHTPSRFSLKTALTTRVFLLLVLIYFTH 262
Cdd:cd17329 152 FRLLFLAAAVLFLLAALVLLFLLPETRPKRR-------------------AAEKTEILRGYKIVLRDRAFLLFLLASFLI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 263 QFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMlMAGYLVMATGMAIGAIAGHGVA 342
Cdd:cd17329 213 SLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKIL-MIGILLFAIGFAVLAFANTLAV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 343 LLG----FSLAAFMFFAMQSIifnWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAatSGLWFAVALLIV 418
Cdd:cd17329 292 LILamivLTLGEMLVFPAVQT---LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGP--GLPWLILAALGL 366
|
....*...
gi 490236148 419 GALASLLI 426
Cdd:cd17329 367 IAAALLLG 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
234-441 |
7.99e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 7.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 234 TRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQIGLLTAIPWIAAAAGGILLPRFARTe 313
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLG-LSATQAGLLTTLPLLAFGLFAPLAPRLARR- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 314 QRSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLA-----AFMFFAMQSIIFNWLPsimsgHMLAGSFGLLNCLGLCGG 388
Cdd:COG2807 80 FGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALigagiAVGNVLLPGLIKRWFP-----DRVGLMTGLYTAAMGLGA 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 490236148 389 FLGPFILGAFEDRTGAATSGLWFAVALLIVGALASLLIKSSSSSTPASAKQAR 441
Cdd:COG2807 155 ALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS 207
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
85-426 |
2.28e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.42 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 85 RIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIG 164
Cdd:cd17365 60 RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 165 AplggllLSLDGMSGWHGWQWMFFIEGLPAIALAfvvwrrlpdkpadarwldshdvqaitavlekeaeetrhtpsrfslk 244
Cdd:cd17365 140 G------FLAAALIPAFGWRSVFLLGGVPPLILL---------------------------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 245 taLTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGY 324
Cdd:cd17365 168 --PLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAG-YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 325 LVMATGMAIGAIAGHGVALLGFSLAAFMF-FAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTG 403
Cdd:cd17365 245 LGAVSLALLGVSPASLVLLYVLVFLAGACvNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGL 324
|
330 340
....*....|....*....|...
gi 490236148 404 AATSGLWFAVALLIVGALASLLI 426
Cdd:cd17365 325 GPESVFLALAIPAALGALAVLLL 347
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-443 |
2.94e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 250 RVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRsRSMLMAGYLVMAT 329
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR-RRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 330 GMAIGAIAGHGVALLGFS-LAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATSG 408
Cdd:COG2814 88 GSLLCALAPSLWLLLAARfLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190
....*....|....*....|....*....|....*
gi 490236148 409 LWFAVALLIVGALASLLIKSSSSSTPASAKQARGE 443
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRE 202
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
85-427 |
4.73e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 4.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 85 RIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIG 164
Cdd:cd17371 60 RFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 165 AplGGLLLSLDGMSGWHGWQWMFFIEGLPAIALAFVVwRRLPDKPadaRWLDShdvqaitavlEKEAEETRHTPSRFSLK 244
Cdd:cd17371 140 T--LLAALLFPLLPPEIAWRVLFLLGALPALLVLFIR-RFVKEPP---QWQAA----------RAARRHFADRPSLRELF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 245 TALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAA----AAGGILLPRFARteqrsRSML 320
Cdd:cd17371 204 SPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGflgyLAGGFLADRIGR-----RNNF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 321 MAGYLVMATGMAI--GAIAGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPFILGAF 398
Cdd:cd17371 279 ALFALGSAISILLyfFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFL 358
|
330 340
....*....|....*....|....*....
gi 490236148 399 EDRTGAATSGLWFAVALLIVGALASLLIK 427
Cdd:cd17371 359 ATSGSLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
48-421 |
7.44e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 7.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 48 ATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGaRRWIARIMITWGIISC-GMAFVTGPTSFYVMRLLLGAAE 126
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFG-RRPVLLAGLLLFILASlLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 127 AGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIgAPLGGLLLSLdgmsgWHGWQWMFFIEGLPAIALAFVVWRRLP 206
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPAL-APLLGGLLLL-----FFGWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 207 DkpadarwldshdvqaiTAVLEKEAEETRHTPSRFslKTALTTRVFLLLVLIY---FTHQFSVYGLSyflPGIIGSWGQL 283
Cdd:cd17320 176 E----------------TLPEEKRKPLLSSLLRAY--KRVLKNRRFLGYALALglsFAGLFAYLAAA---PFIYIEQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 284 TPLQIGLLTAIPWIAAAAGGILLPRFARTeQRSRSMLMAG--YLVMATGMAIGAIAGHGVALLGFSLAAFMFFAMQSIIF 361
Cdd:cd17320 235 SPAQFGLLFALNAIALILGSLLNGRLVRR-FGPRRLLRLGllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIF 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490236148 362 nwlPSIMSGHM-----LAGSFG-LLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGAL 421
Cdd:cd17320 314 ---PNATSLALepfphVAGTASaLLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-205 |
9.20e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.49 E-value: 9.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 27 PLLIVAYIISFIDRTNIGMAKATMSV----DIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGII 102
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLyaaeLGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 103 SCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHG 182
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL------LGGFLYDAFG 352
|
170 180
....*....|....*....|...
gi 490236148 183 WQWMFFIEGLPAIALAFVVWRRL 205
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
49-333 |
1.03e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 49 TMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAG 128
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 129 LYPGIIYYLTLWFGREERAKATGLFL----LGVCLANIIGAplgglllsldgMSGWHGWQWMFFIEGLpAIALAFVVWRR 204
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEaalgLGIAVGPLLGG-----------LLAAISWRYPFFLLAA-LIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 205 LPDKPadarwldshdvqaitavleKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLT 284
Cdd:cd17474 172 LLPEP-------------------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 490236148 285 PLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMATGMAI 333
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLL 281
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
66-207 |
1.07e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.25 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 66 GLFFLTYAVLEI----PSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWF 141
Cdd:TIGR00880 1 GLLLAGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490236148 142 GREERAKATGLFLLGVCLANIIGAPLGGLllsldgMSGWHGWQWMFFIEGLPAIALAFVVWRRLPD 207
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGV------LAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
92-259 |
1.81e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.92 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 92 IARIMITWGIISCGMAfvTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAplgglL 171
Cdd:PRK03893 90 ISIVLFSVGTLACGFA--PGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAA-----Q 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 172 LSLDGMSGWhGWQWMFFIeGLPAIALAFVVWRRLPDKPA-DARWLDSHDVQAITAVLekeaeetrHTPSRFSLKTALTTR 250
Cdd:PRK03893 163 VYSLVVPVW-GWRALFFI-GILPIIFALWLRKNLPEAEDwKEKHAGKAPVRTMVDIL--------YRGEHRIINILLTLA 232
|
....*....
gi 490236148 251 VFLLLVLIY 259
Cdd:PRK03893 233 AAAALWFCF 241
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
49-213 |
3.08e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 42.67 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 49 TMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGP-TSFYVMRLLLGAAEA 127
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSySVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 128 GLYPGiIYYLTLWFGREERAKATGLFL----LGVCLANIIGAPLGGLLLSLDGMSGWHGWQWMFFIEG-----LPAIALA 198
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPagillLPALLIF 185
|
170
....*....|....*
gi 490236148 199 FVVWRRLPDKPADAR 213
Cdd:TIGR00886 186 FVGADTPPGKPATGK 200
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
85-277 |
3.20e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 43.10 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 85 RIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERakatGLFLLGVCLANIIG 164
Cdd:cd17439 60 RIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKR----GEHLSWLCMFWMIG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 165 APLGGLLL-SLDGMSGW----------HGWQWMFFIEGLPAIAlAFVVWRRLPDKPADARWLDSHD-VQAITAVLEKEAE 232
Cdd:cd17439 136 GIYASAMAwAIIPHYGWsfqmgsayqfHSWRVFVLVCAFPSVF-AIGALTTMPESPRFFLENGKHDeAWMVLKQVHDTNM 214
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 490236148 233 ETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGII 277
Cdd:cd17439 215 RAKGHPERVFSVTHIKRRITLMMMAVWFTMSFSYYGLTVWFPDMI 259
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
250-443 |
4.23e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 4.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 250 RVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQIGLLTAIPWIAAAAG----GILLPRFARteqrsRSMLMAGYL 325
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFG-LSAAQLGLLFAIPVLVGALLriplGFLVDRFGP-----RRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 326 VMATGMAIGAIAGHGVALLGFSL-----AAFMFFAMQSIIFNWLPSIMSGHMLagsfGLLNCLGLCGGFLGPFILGAFED 400
Cdd:COG2223 79 LLGIGLLLLALAVSYWLLLLLGLllgigGGGSFAVGIALVSKWFPPDRRGLAL----GLAAGGGNLGAAVAAFLAPLLIA 154
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 490236148 401 RTGAATSGLWFAVALLIVGALASLLIKSSSSSTPASAKQARGE 443
Cdd:COG2223 155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD 197
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
55-424 |
5.75e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 5.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 55 GLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGII 134
Cdd:cd17478 27 GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 135 YYLTLwFGREERAKATGLFL----LGVCLANIIGAPLGGLLlsldgmsGWHGWQWMFFIeglPAIALAFVVWRRLPDKPa 210
Cdd:cd17478 107 RLASQ-AAGGRRGLAMSIFSvggnLGFALGPLIAAALVALF-------GGLGLLILLII---PGLAVALLLLRLRPLKK- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 211 darwldshdvqaitavlekEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQlTPLQIGL 290
Cdd:cd17478 175 -------------------PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGY-SLVFAGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 291 LTAIPWIAAAAGGILLPRFARTEQRsRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSG 370
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGR-RRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490236148 371 HMLAGSfGLLNCLGLCGGFLGPFILGAFEDRTGAATSgLWFAVALLIVGALASL 424
Cdd:cd17478 314 NVGLAS-GLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
53-425 |
5.87e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 5.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 53 DIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRW--IARIMITwGIISCGMAFVTGPTSFYVMRLLLGAAEAGLY 130
Cdd:cd17490 25 SLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLfiIIGLLFT-VLASLIMILFPSPWGLLIARFLSGIAAATWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 131 PGIIYYLTLwFGREERAKATGLFLLGVCLANIIGAPLGGLLLSLDgmsGWHGWQWMFFIEGLPAIALAFvvwrrlpdkpa 210
Cdd:cd17490 104 SFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHF---GMRAPFLLAALAGVLGFILSL----------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 211 darwldshdvqaitAVLEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGL 290
Cdd:cd17490 169 --------------FIKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 291 LTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMA-------------TGMAIGAIAGHGvalLGFSLAAFMFFAMQ 357
Cdd:cd17490 235 LSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGaycflipfapnltLLYLLQALNGFG---TGILFPLLMSLSIE 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490236148 358 SIifnwlpsimSGHMLAGSFGLLNCLGLCGGFLGPFILGAFEDRTGAATsGLWFAVALLIVGALASLL 425
Cdd:cd17490 312 GV---------PAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT-GFFVIGVIALLAAILSLA 369
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
250-391 |
5.90e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.23 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 250 RVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMAT 329
Cdd:cd06179 262 RNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTA 341
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490236148 330 GMAIGAIAGHG--VALLGFS-LAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLG 391
Cdd:cd06179 342 FLALLALITPDnkALAIAFSvLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVG 406
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
43-277 |
9.79e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 41.45 E-value: 9.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 43 IGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLL 122
Cdd:cd17438 18 VGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLIS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 123 GAAEAGLYPGIIYYLTLWFGREERakatGLFLLGVCLANIIGAPLGGLLL-SLDGMSGW----------HGWQWMFFIEG 191
Cdd:cd17438 98 GFGIGGSLPIVFAYFSEFLAREKR----GEHLSWLCMFWMIGGLYASAMAwSIIPHYGWgfsmgtnyhfHSWRVFVIICA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 192 LPAIAlAFVVWRRLPDKPADARWLDSHD-VQAITAVLEKEAEETRHTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLS 270
Cdd:cd17438 174 LPCIA-SIIALKFMPESPRFLLEMGKHDeAWMILKNIHDTNMRAKGTPEKVFTVSNIKRKNTLFLAVVWFTMAFSYYGLT 252
|
....*..
gi 490236148 271 YFLPGII 277
Cdd:cd17438 253 VWFPDMI 259
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-424 |
1.61e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 53 DIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPG 132
Cdd:cd17477 25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 133 IIYYLTLWFGREERAKATGLFLLGVCLANIIGAplgglllSLDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDKPADA 212
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALGP-------LLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 213 rwldshdvqaitavlekeaeetrhTPSRFSLKTALTTRVFLLLVLIYFTHQFSVYGLsyfLPgIIGSWGQLTPLQIGLLT 292
Cdd:cd17477 178 ------------------------AESISLRRLLRIAPLALLGAFVAGFLEGAFYSL---LP-LYGLRLGLSVAQAALLL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 293 AIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMATGMAIGAIAGHGVALLGFS-LAAFMFFAMQSIIFNWLPSIMSGH 371
Cdd:cd17477 230 AAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLfLWGGAAGPLYTLALALAGDRLPGD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490236148 372 -MLAGSFGLLNCLGLcGGFLGPFILGAFEDRTGaaTSGLWFAVALLIVGALASL 424
Cdd:cd17477 310 eLVAANAALLLLYGL-GSVIGPLLAGALMDAFG--PHGLFLFLAAVALLFLLFL 360
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
29-216 |
1.72e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.44 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 29 LIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLeIPSNLFL-TRIGARR--WIARIMITWGIISCG 105
Cdd:TIGR00711 7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAIS-IPLTGWLaKRFGTRRlfLISTFAFTLGSLLCG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 106 MAfvTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAplgglllsldGMSGW----H 181
Cdd:TIGR00711 86 VA--PNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGP----------TLGGWiienY 153
|
170 180 190
....*....|....*....|....*....|....*.
gi 490236148 182 GWQWMFFIEGLPAIALAFVVWRRLP-DKPADARWLD 216
Cdd:TIGR00711 154 HWRWIFLINVPIGIIVVVVAFFILPrDKPAASENFD 189
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-361 |
2.39e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 29 LIVAYIISFIDRTNIGMAKATMSVDIGLSATAFGLGAGLFFLTYAVLEIPSNLFLTRIGARRWIARIMITWGIISCGMAF 108
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 109 VTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGVCLANIIGAPLgglllsLDGMSGWHGWQWMFF 188
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL------GGWLTDNLSWRWIFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 189 IEgLPAIALAFVvwrrlpdkpadarwldshdvqaITAVLekeaeetrhtpsRFSLktaLTTRVFLLLVLIYFTHQFSVYG 268
Cdd:cd17503 155 IN-LPIGILALL----------------------LAPLL------------DLRL---FKDRNFTLGLLLSFLLGLGLFG 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 269 LSYFLPGIIGSWGQLTPLQIGLLTA----IPWIAAAAGGILLPRFArteqrSRSMLMAGYLVMATGMAIGAIAGHGVALL 344
Cdd:cd17503 197 AMFLLPLYLQNVLGYSAFESGLVLApgglASAILSPLVGRLLDKFG-----PRLLLLAGLLLLALGTLLLAFLTPDTSLW 271
|
330
....*....|....*..
gi 490236148 345 GFSLAAFMFFAMQSIIF 361
Cdd:cd17503 272 LIILPLFIRGLGMGLVF 288
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
46-417 |
3.03e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 46 AKATMSVDIGLSATAFGLGA--GLFFLTYAVleipsnlflTRIGaRRWIARIMITWGII-SCGMAFVTGPTSFYVmrLLL 122
Cdd:pfam00083 40 SLAALSVLSGLIVSIFSVGCfiGSLFAGKLG---------DRFG-RKKSLLIANVLFVIgAVLQGAAKGKWSVYQ--LIV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 123 GAAEAGLYPGIIYYLTLWFGRE-----ERAKATGLFLLGVCLANIIGAplgGLLLSLDGMSGWHGWQWMFFIEGLPAIAL 197
Cdd:pfam00083 108 GRVLVGIGVGGASVLAPMYISEiapkkLRGALGSLYQLAITFGILLAY---IFGLGLNKTSNSDGWRIPLGLQLVPALLL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 198 AFVVWrRLPDKPadaRWL---------------------DSHDVQAITAVLEKEAEETRHTPSRFsLKTALTTRVFLLLV 256
Cdd:pfam00083 185 IIGLL-FLPESP---RWLvekgrleearevlaklrgvpdVDRELDEIKDSLEAGQEAEKASWKEL-FSTKTRRQRLLIGV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 257 LIYFTHQFS-VYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILL-PRFARteqrsRSMLMAGYLVMATGMAIG 334
Cdd:pfam00083 260 MLQIFQQLTgINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLvDRFGR-----RPLLLLGAAGMAICFVIL 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 335 AI------AGHGVALLGFSLAAFMFFAMQSIIFNWLPSIMSGHMLAGSF-GLLNCLGLCGGFLGPFILGAFE----DRTG 403
Cdd:pfam00083 335 GIvallgvSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVrSKAMALATAANWLANFLIGFLFpiitDAIG 414
|
410
....*....|....
gi 490236148 404 AATSGLWFAVALLI 417
Cdd:pfam00083 415 LGYTFFIFAGLLVL 428
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
377-426 |
3.09e-03 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 39.94 E-value: 3.09e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 490236148 377 FGLLNCLGLCGGFLGPFILGAFEDRTGAATSGLWFAVALLIVGALASLLI 426
Cdd:pfam11700 420 FSLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAILLVVPLPLLLLV 469
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
36-356 |
5.39e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.17 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 36 SFIDRTNIGMAKATMSVDIGLSATAFGLGA--GLFFltyavleipSNLFLTRIGaRRWIARIMITWGIISCGMAFVTGPT 113
Cdd:cd17357 33 TLVDRYGLNLSDSELDLLWSLIVSIFFIGGaiGSFI---------SAFLANRFG-RKNGLLISNALLVVSSLLMFLSKSA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 114 SFYVMrLLLGAAEAGLYPGIIYYLTLWFGREERAK----ATGLFL-LGVCLANIIGAplggLLLSLDGMSGWHGWQWMFF 188
Cdd:cd17357 103 KSPEL-LIFGRFLVGIACGLSTGFVPMYLQEISPSelrgALGSLTqIGVTLGILLGQ----VFGLPSVLGTETLWPYLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 189 IEGLPAIaLAFVVWRRLPDKPadaRWL--DSHDVQAITAVL---------------EKEAEETRHTPSRF-SLKTALT-- 248
Cdd:cd17357 178 FPGIPAL-LQLAALPFFPESP---KFLliSKGDEEEAEKSLkflrgieddvdqeleEIKKESEQMGDQKQvSLMQLLRdp 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 249 --TRVFLLLVLIYFTHQFS-VYGLSYFLPGIIGSWG------QLTPLQIGLLTAipwIAAAAGGILLPRFARteqrsRSM 319
Cdd:cd17357 254 slRLPLLLVLVVSASQQFSgINAIFFYSTFIFENAGfspqlaEWANLGIGIVNV---LSTIVGPFLIEKVGR-----RPL 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 490236148 320 LMAGYLVMA---TGMAIGAIAGHGVALLGFSLAAF-----MFFAM 356
Cdd:cd17357 326 LLISLSVCAvalLLMSVFLFLSEQNSWMSYGCIVAiflfiFFFAI 370
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
85-426 |
6.15e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.79 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 85 RIGARRWIARIMITWGIISCGMAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLWFGREERAKATGLFLLGV----CLA 160
Cdd:PRK11551 76 RIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVpfggALA 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 161 NIIGaplgglllslDGMSGWHGWQWMFFIEGLPAIALAFVVWRRLPDKPADARwldshdvqaitavlEKEAEETRHTPSR 240
Cdd:PRK11551 156 SVIG----------VLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ--------------AAGAGKQRAPVLR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 241 --FSLKTALTTrvfLLLVLIYFTHQFSVYGLSYFLPGIIGSWGqLTPLQIGLLTAIPWIAAAAG----GILLPRFarteq 314
Cdd:PRK11551 212 alFGEGRATAT---LLLWISYFFTLIVLYFLLNWLPSLLVGQG-LSRSQAGLVQIAFNIGGALGslliGALMDRL----- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 315 RSRSMLMAGYLVMATGMAIGAIAGHGVALLGFSLAAFMFF-AMQSIIFNWLPSIMSGHMLAGSFGLLNCLGLCGGFLGPF 393
Cdd:PRK11551 283 RPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVvGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPL 362
|
330 340 350
....*....|....*....|....*....|....
gi 490236148 394 ILGAFEdRTGAATSGLWFAVA-LLIVGALASLLI 426
Cdd:PRK11551 363 LAGQLL-ALGRSTVGVIGASIpVILVAALAALLL 395
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
250-425 |
7.10e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 7.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 250 RVFLLLVLIYFTHQFSVYGLSYFLPGIIGSWGQLTPLQIGLLTAIPWIAAAAGGILLPRFARTEQRSRSMLMAGYLVMAT 329
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 330 GMAIGAIAGHGVALLgfsLAAFMFFAMQSIIFNWLPSIMSGHMLAGSFGLLN----CLGLCGGFLGPFILGAFEDRTGAA 405
Cdd:cd17330 254 GLLLLPFASSVPLLV---LAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQgiiqSLQSLARIIGPLLAGPLYSFLGPG 330
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170 180
....*....|....*....|
gi 490236148 406 TSgLWFAVALLIVGALASLL 425
Cdd:cd17330 331 VP-FLLAAGLLLIALFLLSL 349
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| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
68-202 |
7.29e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.37 E-value: 7.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236148 68 FFLTYAVLEIPSNLFLTRIGARRwiariMITWGIISCG-------MAFVTGPTSFYVMRLLLGAAEAGLYPGIIYYLTLW 140
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKR-----VLGYSILITAlltlltpLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKW 139
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490236148 141 FGREERAKATGLFLLGVCLANIIGAPlgglllSLDGMSGWHGWQWMFFIEGlpAIALA-FVVW 202
Cdd:cd17318 140 APPLERSRLTSIAYSGSQFGTVIAMP------LSGFLCESLGWPSIFYIFG--GLGLLwCLLW 194
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