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Conserved domains on  [gi|490236661|ref|WP_004134970|]
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MoxR family ATPase [Gardnerella greenwoodii]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 60-361 7.00e-121

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 351.01  E-value: 7.00e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661  60 LRSRFAQTLVGQEALRESLILTLIAGGHILIESVPGLAKTTAAQTLATAMSGSFRRVQCTPDLMPADLVGTQVFDFASQR 139
Cdd:COG0714    6 LRAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 140 FTTQIGPIHANIILLDEINRSNAKTQSAMLEAMAEGATTIGGERIALPQPFMVIATQNPIEEEGTFNLPEAQMDRFMVKA 219
Cdd:COG0714   86 FEFRPGPLFANVLLADEINRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 220 IMTYPNPDEEVRMLQLLTQRGSDVVDPAtlstqrISLQDVVFMRAAARHIHVSEAVMKYAVDIVATSRGEGShplatint 299
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRHLAEVEPV------LSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPD-------- 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490236661 300 lVRMGASPRASIALIRIAQAHALLSGRDYVIPEDVKLFAHEVLRHRILLTFEALADSITTDQ 361
Cdd:COG0714  232 -LRKGPSPRASIALLRAARALALLDGRDYVTPDDVKAVAGPVLKHRLILSPEADAEGVTADD 292
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 60-361 7.00e-121

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 351.01  E-value: 7.00e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661  60 LRSRFAQTLVGQEALRESLILTLIAGGHILIESVPGLAKTTAAQTLATAMSGSFRRVQCTPDLMPADLVGTQVFDFASQR 139
Cdd:COG0714    6 LRAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 140 FTTQIGPIHANIILLDEINRSNAKTQSAMLEAMAEGATTIGGERIALPQPFMVIATQNPIEEEGTFNLPEAQMDRFMVKA 219
Cdd:COG0714   86 FEFRPGPLFANVLLADEINRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 220 IMTYPNPDEEVRMLQLLTQRGSDVVDPAtlstqrISLQDVVFMRAAARHIHVSEAVMKYAVDIVATSRGEGShplatint 299
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRHLAEVEPV------LSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPD-------- 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490236661 300 lVRMGASPRASIALIRIAQAHALLSGRDYVIPEDVKLFAHEVLRHRILLTFEALADSITTDQ 361
Cdd:COG0714  232 -LRKGPSPRASIALLRAARALALLDGRDYVTPDDVKAVAGPVLKHRLILSPEADAEGVTADD 292
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 87-216 1.08e-65

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 204.33  E-value: 1.08e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   87 HILIESVPGLAKTTAAQTLATAMSGSFRRVQCTPDLMPADLVGTQVFDFASQRFTTQIGPIHANIILLDEINRSNAKTQS 166
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGTEVFDQKTREFEFRPGPVFANVLLADEINRAPPKTQS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 490236661  167 AMLEAMAEGATTIGGERIALPQPFMVIATQNPIEEEGTFNLPEAQMDRFM 216
Cdd:pfam07726  81 ALLEAMQERQVTIDGETHPLPEPFFVLATQNPIEQEGTYPLPEAQLDRFL 130
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 125-344 3.99e-10

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 60.43  E-value: 3.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 125 ADLVGTQVFDFASQRFTTQIG---PIHANIILLDEINRSNAKTQSAMLEAMAEGATTI--GGERIALPQPFMVIATQNPI 199
Cdd:cd17706   79 AGLTAAVVRDSETGEWYLEAGalvLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIakAGIVTTLNARCSILAAANPK 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 200 EeeGTFN----------LPEAQMDRF-MVKAIMTYPNP--DEEVRMLQLLTQRGSDVVDPATLSTQRISLqDVVFMR--- 263
Cdd:cd17706  159 G--GRYNpklspieninLPSPLLSRFdLIFVIRDDPDEerDEELAEHIIDLHRGSDPEEQVKPEEDGIPI-DIELLRkyi 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 264 AAARHIH--VSEAVMKYAVDIVATSRGEGshplatiNTLVRMGASPRASIALIRIAQAHALLSGRDYVIPEDVKLfAHEV 341
Cdd:cd17706  236 LYARQIHpkISEEAREKLVRWYVELRKES-------ERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEE-AIRL 307


                 ...
gi 490236661 342 LRH 344
Cdd:cd17706  308 VRH 310
MCM smart00350
minichromosome maintenance proteins;
151-334 1.21e-04

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 43.79  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   151 IILLDEINRSNAKTQSAMLEAMAEGATTIGGERI--ALPQPFMVIATQNPIE--------EEGTFNLPEAQMDRF-MVKA 219
Cdd:smart00350 303 VCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGIttTLNARCSVLAAANPIGgrydpkltPEENIDLPAPILSRFdLLFV 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   220 IMTYPNPDEEVRMLQLLTqrGSDVVDPATLSTQRISLQDVVFMR---AAARH-IH--VSEAVMKYAVDIVATSRGEGShp 293
Cdd:smart00350 383 VLDEVDEERDRELAKHVV--DLHRYSHPEEDEAFEPPLSQEKLRkyiAYAREkIKpkLSEEAADKLVKAYVDLRKEDS-- 458

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 490236661   294 laTINTLVRMGASPRASIALIRIAQAHALLSGRDYVIPEDV 334
Cdd:smart00350 459 --QTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADV 497
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 60-361 7.00e-121

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 351.01  E-value: 7.00e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661  60 LRSRFAQTLVGQEALRESLILTLIAGGHILIESVPGLAKTTAAQTLATAMSGSFRRVQCTPDLMPADLVGTQVFDFASQR 139
Cdd:COG0714    6 LRAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 140 FTTQIGPIHANIILLDEINRSNAKTQSAMLEAMAEGATTIGGERIALPQPFMVIATQNPIEEEGTFNLPEAQMDRFMVKA 219
Cdd:COG0714   86 FEFRPGPLFANVLLADEINRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 220 IMTYPNPDEEVRMLQLLTQRGSDVVDPAtlstqrISLQDVVFMRAAARHIHVSEAVMKYAVDIVATSRGEGShplatint 299
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRHLAEVEPV------LSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPD-------- 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490236661 300 lVRMGASPRASIALIRIAQAHALLSGRDYVIPEDVKLFAHEVLRHRILLTFEALADSITTDQ 361
Cdd:COG0714  232 -LRKGPSPRASIALLRAARALALLDGRDYVTPDDVKAVAGPVLKHRLILSPEADAEGVTADD 292
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 87-216 1.08e-65

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 204.33  E-value: 1.08e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   87 HILIESVPGLAKTTAAQTLATAMSGSFRRVQCTPDLMPADLVGTQVFDFASQRFTTQIGPIHANIILLDEINRSNAKTQS 166
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGTEVFDQKTREFEFRPGPVFANVLLADEINRAPPKTQS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 490236661  167 AMLEAMAEGATTIGGERIALPQPFMVIATQNPIEEEGTFNLPEAQMDRFM 216
Cdd:pfam07726  81 ALLEAMQERQVTIDGETHPLPEPFFVLATQNPIEQEGTYPLPEAQLDRFL 130
AAA_lid_2 pfam17863
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 294-366 4.95e-18

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465538 [Multi-domain]  Cd Length: 73  Bit Score: 77.64  E-value: 4.95e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490236661  294 LATIN-TLVRMGASP-RASIALIRIAQAHALLSGRDYVIPEDVKLFAHEVLRHRIllTFEALADSITTDQVIDAL 366
Cdd:pfam17863   1 LATRAhLAIALGVSPrRADLALLRAARALAALEGRDYVTPEDVKEAAPLVLAHRL--RREPEAEGETAEEILEEI 73
ChlI COG1239
Mg-chelatase subunit ChlI [Coenzyme transport and metabolism];
148-346 2.76e-11

Mg-chelatase subunit ChlI [Coenzyme transport and metabolism];


Pssm-ID: 440852 [Multi-domain]  Cd Length: 344  Bit Score: 64.00  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 148 HANIILLDEINR-----SNAktqsaMLEAMAEGATTIggER----IALPQPFMVIATQNPieEEGtfNLPEAQMDRF--- 215
Cdd:COG1239  136 HRGILYVDEVNLlddhlVDV-----LLDAAAMGRNTV--ERegvsVSHPARFVLVGTMNP--EEG--ELRPQLLDRFgls 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 216 -MVKAIMtypnpDEEVRMlQLLTQRGSDVVDPATLS----------TQRISLqdvvfMRAAARHIHVSEAVMKYAVDIVa 284
Cdd:COG1239  205 vEVEGPR-----DPEERV-EIVRRRLAFEADPEAFAaeyaeeqaelRERIAA-----ARELLPEVTIPDELLRYIAELC- 272

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490236661 285 tsrgegshplatintlVRMG-ASPRASIALIRIAQAHALLSGRDYVIPEDVKLFAHEVLRHRI 346
Cdd:COG1239  273 ----------------IALGvDGHRADIVIARAARALAALEGRTEVTAEDIRRAAELALPHRL 319
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 125-344 3.99e-10

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 60.43  E-value: 3.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 125 ADLVGTQVFDFASQRFTTQIG---PIHANIILLDEINRSNAKTQSAMLEAMAEGATTI--GGERIALPQPFMVIATQNPI 199
Cdd:cd17706   79 AGLTAAVVRDSETGEWYLEAGalvLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIakAGIVTTLNARCSILAAANPK 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 200 EeeGTFN----------LPEAQMDRF-MVKAIMTYPNP--DEEVRMLQLLTQRGSDVVDPATLSTQRISLqDVVFMR--- 263
Cdd:cd17706  159 G--GRYNpklspieninLPSPLLSRFdLIFVIRDDPDEerDEELAEHIIDLHRGSDPEEQVKPEEDGIPI-DIELLRkyi 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 264 AAARHIH--VSEAVMKYAVDIVATSRGEGshplatiNTLVRMGASPRASIALIRIAQAHALLSGRDYVIPEDVKLfAHEV 341
Cdd:cd17706  236 LYARQIHpkISEEAREKLVRWYVELRKES-------ERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEE-AIRL 307


                 ...
gi 490236661 342 LRH 344
Cdd:cd17706  308 VRH 310
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 151-334 4.32e-05

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 44.71  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 151 IILLDEINRSNAKTQSAMLEAMAEGATTI--GGERIALPQPFMVIATQNP--------IEEEGTFNLPEAQMDRF-MVKA 219
Cdd:cd17758  107 ICCIDEFDKMDESDRTAIHEVMEQQTISIakAGITTTLNARTSILAAANPaygrynprRSPEQNINLPAALLSRFdLLFL 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 220 IMTYPNPDEEVRMLQLLTQRGSDVVDPATlstqRISLQDVVFMRA---AARHIH--VSEAVMKYAVDIVATSRGEGSHPL 294
Cdd:cd17758  187 ILDKPDRDNDLRLAEHVTYVHQHNKQPDS----DFEPLDPKLLRAyiaLAKRKRptVPPALADYIVQAYVEMRQEAKRSK 262

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 490236661 295 ATINTlvrmgaSPRASIALIRIAQAHALLSGRDYVIPEDV 334
Cdd:cd17758  263 DFTFT------TPRTLLAILRLSQALARLRLSDSVEIDDV 296
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 87-215 1.05e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 41.89  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   87 HILIESVPGLAKTTAAQTLATAMSG-SFRRVQCTPDLMPADLVG-----TQVFDFASQRFTTQIgpIHANIILLDEINRS 160
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNrPVFYVQLTRDTTEEDLFGrrnidPGGASWVDGPLVRAA--REGEIAVLDEINRA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 490236661  161 NAKTQSAMLEAMAEGATTI--GGERIALPQP-FMVIATQNPIEEEGtFNLPEAQMDRF 215
Cdd:pfam07728  79 NPDVLNSLLSLLDERRLLLpdGGELVKAAPDgFRLIATMNPLDRGL-NELSPALRSRF 135
MCM smart00350
minichromosome maintenance proteins;
151-334 1.21e-04

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 43.79  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   151 IILLDEINRSNAKTQSAMLEAMAEGATTIGGERI--ALPQPFMVIATQNPIE--------EEGTFNLPEAQMDRF-MVKA 219
Cdd:smart00350 303 VCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGIttTLNARCSVLAAANPIGgrydpkltPEENIDLPAPILSRFdLLFV 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   220 IMTYPNPDEEVRMLQLLTqrGSDVVDPATLSTQRISLQDVVFMR---AAARH-IH--VSEAVMKYAVDIVATSRGEGShp 293
Cdd:smart00350 383 VLDEVDEERDRELAKHVV--DLHRYSHPEEDEAFEPPLSQEKLRkyiAYAREkIKpkLSEEAADKLVKAYVDLRKEDS-- 458

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 490236661   294 laTINTLVRMGASPRASIALIRIAQAHALLSGRDYVIPEDV 334
Cdd:smart00350 459 --QTESRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADV 497
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 151-334 2.22e-04

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 42.81  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 151 IILLDEINRSNAKTQSAMLEAMAEGATTIGGERI--ALPQPFMVIATQNPIEEE--------GTFNLPEAQMDRFMVKAI 220
Cdd:cd17755  109 ICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIitTLNARTSILASANPIGSRynpkltvvENIDLPPTLLSRFDLIYL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661 221 MTyPNPDEE---------VRMLQLLTQRGS--DVVDPATLSTqrislqdvvFMRAAARHIH--VSEAVMKYAVDIVATSR 287
Cdd:cd17755  189 VL-DKVDEKydrrlakhlVSLYLEDTPEHIqdEVLDVEVLTD---------YISYAREHIHpkLSEEAAQELVQAYVDMR 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 490236661 288 GEGSHPLATINtlvrmgASPRASIALIRIAQAHALLSGRDYVIPEDV 334
Cdd:cd17755  259 KMGSDARKRIT------ATPRQLESLIRLAEAHAKMRLSNVVEAEDV 299
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 265-344 4.97e-03

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 35.60  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661  265 AARHIH--VSEAVMKYAVDIVATSRGEGSHPLATINTLVRMGASprasiaLIRIAQAHALLSGRDYVIPEDVKlFAHEVL 342
Cdd:pfam17855  10 AREKIKpkLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLES------LIRLSEAHAKMRLSEIVTEEDVE-EAIRLL 82


                  ..
gi 490236661  343 RH 344
Cdd:pfam17855  83 KE 84
bpMoxR pfam20030
MoxR domain in the MoxR-vWA-beta-propeller ternary systems; Core MoxR component domain of the ...
 66-234 8.66e-03

MoxR domain in the MoxR-vWA-beta-propeller ternary systems; Core MoxR component domain of the MoxR-vWA-beta-propeller ternary systems, a class of NTP-dependent biological conflict systems.


Pssm-ID: 437862 [Multi-domain]  Cd Length: 205  Bit Score: 37.22  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661   66 QTLVGQEALRESLILTLIAGGHILIESVPGlakttaaqtlaTAMSGSFRRVqctpdlmpADLVGTQVFDFASQRFT--TQ 143
Cdd:pfam20030  12 TGFVGKDEIIDLLGLALVARENLFLLGPPG-----------TAKSALVRRL--------AARLGGRYFEYLLTRFTepNE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490236661  144 I-GPI-------------------HANIILLDEINRSNAKTQSAMLEAMAEGATTIGGERIALPQpFMVIATQNPIEEEG 203
Cdd:pfam20030  73 LfGPFdirklregelvtntegmlpEASLVFLDELFNANSAILNSLLMVLNERIFRRGKETRKLPA-LMFVGASNHLPEDE 151

                         170       180       190
                  ....*....|....*....|....*....|.
gi 490236661  204 TFNlpeAQMDRFMVKAIMTYPNPDEEVRMLQ 234
Cdd:pfam20030 152 ALA---ALFDRFLLRVKCDNVPPDQLEAVLA 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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