|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13054 |
PRK13054 |
lipid kinase; Reviewed |
3-297 |
0e+00 |
|
lipid kinase; Reviewed
Pssm-ID: 237281 [Multi-domain] Cd Length: 300 Bit Score: 530.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 3 TFPASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDG 82
Cdd:PRK13054 2 TFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 83 DM--ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGV 160
Cdd:PRK13054 82 DArpALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 161 SYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTG-EELIPTLFSTLAN 239
Cdd:PRK13054 162 AYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPApQELLPTLLSTLTG 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 490240393 240 P-ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLLR 297
Cdd:PRK13054 242 GsEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
|
|
| lip_kinase_YegS |
TIGR03702 |
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ... |
6-296 |
4.06e-162 |
|
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 163414 Cd Length: 293 Bit Score: 452.64 E-value: 4.06e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 6 ASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDMA 85
Cdd:TIGR03702 1 KALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 86 --LGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGVSYL 163
Cdd:TIGR03702 81 paLGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 164 IHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEELIPTLFSTLANPENS 243
Cdd:TIGR03702 161 ITGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKN 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 490240393 244 PNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLL 296
Cdd:TIGR03702 241 PEFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
|
|
| TIGR00147 |
TIGR00147 |
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ... |
1-289 |
6.22e-124 |
|
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161732 [Multi-domain] Cd Length: 293 Bit Score: 355.66 E-value: 6.22e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 1 MSTFPASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVER 80
Cdd:TIGR00147 1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 81 DGDMALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGV 160
Cdd:TIGR00147 81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYCFINMAGGGFGTEITTETPEKLKAALGSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 161 SYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEELIPTLFSTLANP 240
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 490240393 241 E----NSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRL 289
Cdd:TIGR00147 241 EgkhtDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
|
|
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
8-292 |
9.16e-90 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 269.03 E-value: 9.16e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 8 LLILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDgdM 84
Cdd:COG1597 6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG--P 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 85 ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLI 164
Cdd:COG1597 84 PLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRY-FLNVAGIGFDAEVVERANRALKRRLGKLAYVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 165 HGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGE---ELIPTLFSTLA-NP 240
Cdd:COG1597 163 AALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLsrlRLLRLLPRLLRgRH 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 490240393 241 ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKT-FRMELLPAALRCRLPPD 292
Cdd:COG1597 243 LRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATpLEFEVLPGALRVLVPAD 295
|
|
| PRK13337 |
PRK13337 |
putative lipid kinase; Reviewed |
20-269 |
2.00e-46 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183982 [Multi-domain] Cd Length: 304 Bit Score: 158.29 E-value: 2.00e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 20 SLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDMALGILPLGTANDFAT 99
Cdd:PRK13337 20 NLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENRPKLGIIPVGTTNDFAR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 100 SVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIHGLMRMDALKPDRCE 179
Cdd:PRK13337 100 ALHVPRDIEKAADVIIEGHTVPVDIGKANNRY-FINIAGGGRLTELTYEVPSKLKTMLGQLAYYLKGIEMLPSLKATDVR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 180 IRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTG---EELIPtlFSTLA---NPENSPNIIDGVSSW 253
Cdd:PRK13337 179 IEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKanlAELIH--IATLAlrgEHIKHPKVIYTKANR 256
|
250
....*....|....*.
gi 490240393 254 FEITAPHEMTFNLDGE 269
Cdd:PRK13337 257 IKVSSFDKMQLNLDGE 272
|
|
| PRK13057 |
PRK13057 |
lipid kinase; |
8-292 |
2.80e-38 |
|
lipid kinase;
Pssm-ID: 183857 [Multi-domain] Cd Length: 287 Bit Score: 136.59 E-value: 2.80e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 8 LLILNGKGAN-EPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIdEALKLNVETVIAGGGDGTINEVATALVERDgdMAL 86
Cdd:PRK13057 1 LLLVNRHARSgRAALAAARAALEAAGLELVEPPAEDPDDLSEVI-EAYADGVDLVIVGGGDGTLNAAAPALVETG--LPL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 87 GILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIHG 166
Cdd:PRK13057 78 GILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHY-FFNVASLGLSAELARRLTKELKRRWGTLGYAIAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 167 LMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLH---LRIFTGEELIPTLFSTLANPE-N 242
Cdd:PRK13057 157 LRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDlysLEVAHWWRLLALLPALRRGRHgE 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 490240393 243 SPNIIDGVSSWFEITAPHEMTFNLDGEpLTGKT-FRMELLPAALRCRLPPD 292
Cdd:PRK13057 237 WPDVRAFRTTELELRTRKPRPINTDGE-LTTYTpAHFRVLPKALRVLAPPP 286
|
|
| PRK13059 |
PRK13059 |
putative lipid kinase; Reviewed |
38-287 |
5.01e-37 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183858 Cd Length: 295 Bit Score: 133.24 E-value: 5.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 38 RVTWEKGDAARF--IDEALKLnvetVIAGGGDGTINEVATALVERDGDMALGILPLGTANDFATSVGIPQELASALKLAI 115
Cdd:PRK13059 39 RISLEYDLKNAFkdIDESYKY----ILIAGGDGTVDNVVNAMKKLNIDLPIGILPVGTANDFAKFLGMPTDIGEACEQIL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 116 VGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIG 195
Cdd:PRK13059 115 KSKPKKVDLGKINDKY-FINVASTGLFTDVSQKTDVNLKNTIGKLAYYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLML 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 196 IGNGRQAgGGQQLCPEALINDGLLHLRIFTG---EELIPTLFSTLANP--ENSPNIIDGVSSWFEITAPHEMTFNLDGEp 270
Cdd:PRK13059 194 VFNGQTA-GNFNLAYKAEVDDGLLDVIIIKAcpiIDLIPLFIKVLKGEhlEDVNGLIYFKTDKLEIESNEEIVTDIDGE- 271
|
250
....*....|....*..
gi 490240393 271 ltgktfRMELLPAALRC 287
Cdd:PRK13059 272 ------RGPDFPLNIEC 282
|
|
| PRK00861 |
PRK00861 |
putative lipid kinase; Reviewed |
9-292 |
3.03e-36 |
|
putative lipid kinase; Reviewed
Pssm-ID: 234850 [Multi-domain] Cd Length: 300 Bit Score: 131.28 E-value: 3.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 9 LILN---GKGANEPSLREAVKLLRDEgIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVErdGDMA 85
Cdd:PRK00861 7 LIFNpvaGQGNPEVDLALIRAILEPE-MDLDIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIG--TDIP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 86 LGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIH 165
Cdd:PRK00861 84 LGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCNGQP-MILLAGIGFEAETVEEADREAKNRFGILAYILS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 166 GLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQ-----AGGGQQLCPEalinDGLLHLRIFTGE---ELIPT---LF 234
Cdd:PRK00861 163 GLQQLRELESFEVEIETEDQIITTNAVAVTVANAAPptsvlAQGPGAVIPD----DGLLDVTIVAPKnlaEAVAAsyhLL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 235 ST--LANPENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPD 292
Cdd:PRK00861 239 QTalQGNPAERDDIGYLRAKQVKITTDPPQKVVIDGEVVGTTPIEIECLPRSLKVFAPLQ 298
|
|
| DAGK_cat |
pfam00781 |
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ... |
8-127 |
2.02e-34 |
|
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Pssm-ID: 425868 [Multi-domain] Cd Length: 125 Bit Score: 121.54 E-value: 2.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 8 LLILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDM 84
Cdd:pfam00781 3 LVIVNpksGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLATRP 82
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 490240393 85 ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARV 127
Cdd:pfam00781 83 PLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
|
|
| PRK13055 |
PRK13055 |
putative lipid kinase; Reviewed |
9-269 |
6.38e-30 |
|
putative lipid kinase; Reviewed
Pssm-ID: 237282 [Multi-domain] Cd Length: 334 Bit Score: 115.47 E-value: 6.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 9 LILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDE-ALKLNVETVIAGGGDGTINEVATALVERDGDM 84
Cdd:PRK13055 7 LIYNptsGQEIMKKNVADILDILEQAGYETSAFQTTPEPNSAKNEAKrAAEAGFDLIIAAGGDGTINEVVNGIAPLEKRP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 85 ALGILPLGTANDFATSVGIPQ-ELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGVSYL 163
Cdd:PRK13055 87 KMAIIPAGTTNDYARALKIPRdNPVEAAKVILKNQTIKMDIGRANEDKYFINIAAGGSLTELTYSVPSQLKSMFGYLAYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 164 IHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEEL--IPTLFSTLANPE 241
Cdd:PRK13055 167 AKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLfeLLHLMALILNGG 246
|
250 260 270
....*....|....*....|....*....|...
gi 490240393 242 ---NSPNIIDGVSSWFEIT--APHEMTFNLDGE 269
Cdd:PRK13055 247 khiDDPRVIYIKTSKLTIEplGDDRLMVNLDGE 279
|
|
| PRK12361 |
PRK12361 |
hypothetical protein; Provisional |
34-291 |
1.81e-17 |
|
hypothetical protein; Provisional
Pssm-ID: 183473 [Multi-domain] Cd Length: 547 Bit Score: 82.36 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 34 DIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVerDGDMALGILPLGTANDFA------TSVGIPqeL 107
Cdd:PRK12361 274 DLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELV--NTDITLGIIPLGTANALShalfglGSKLIP--V 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 108 ASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKlKAALGGVSYLiHGLMR-MDALKP-------DRCE 179
Cdd:PRK12361 350 EQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRER-KNALGQLAYL-DGLWRaVNENETltltvtlDDAE 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 180 IRGENFHwhgdALVigIGNGRQA------GGGQqlcPEalINDGLLHL-----------RIFTGEELIptlFSTLANPEN 242
Cdd:PRK12361 428 PQTISTH----SLV--VANAAPFtsllaqGGGE---PN--MTDGLLDItwldsggepgeQLLSLAELA---LSGLGKEPE 493
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 490240393 243 SPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPP 291
Cdd:PRK12361 494 ANKVHHAHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQPASLKVFVPY 542
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
8-117 |
1.33e-16 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 74.26 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 8 LLILNGKGANEpSLREAVKLLRDEGIDIHVRVTWEKGDAARfIDEALKL-NVETVIAGGGDGTINEVATALVERDGDM-- 84
Cdd:smart00046 1 LVFVNPKSGGG-KGEKLLRKFRLLLNPRQVFDLTKKGPAVA-LVIFRDVpDFNRVLVCGGDGTVGWVLNALDKRELPLpe 78
|
90 100 110
....*....|....*....|....*....|....
gi 490240393 85 -ALGILPLGTANDFATSVGIPQELASALKLAIVG 117
Cdd:smart00046 79 pPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLR 112
|
|
| PRK11914 |
PRK11914 |
diacylglycerol kinase; Reviewed |
11-219 |
2.84e-16 |
|
diacylglycerol kinase; Reviewed
Pssm-ID: 237021 [Multi-domain] Cd Length: 306 Bit Score: 77.52 E-value: 2.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 11 LNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVErdGDMALGILP 90
Cdd:PRK11914 18 LSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVISNALQVLAG--TDIPLGIIP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 91 LGTANDFATSVGIPQELASALKLAIV-GRDVAIDIARVNDKTG----FINMATGGFGTRITTETpEKLKAALGGVSYLIH 165
Cdd:PRK11914 96 AGTGNDHAREFGIPTGDPEAAADVIVdGWTETVDLGRIQDDDGivkwFGTVAATGFDSLVTDRA-NRMRWPHGRMRYNLA 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 490240393 166 GLMRMDALK--PDRCEIRGENfHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLL 219
Cdd:PRK11914 175 MLAELSKLRplPFRLVLDGTE-EIVTDLTLAAFGNTRSYGGGMLICPNADHTDGLL 229
|
|
| YegS_C |
pfam19279 |
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ... |
177-286 |
8.73e-05 |
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YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.
Pssm-ID: 437111 Cd Length: 158 Bit Score: 42.18 E-value: 8.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 177 RCEIRGENFHWHGdALVIgIGNGRQAGGGQQLCPEALINDGLLHLRIFTGE------ELIPTLFST--LANPEnsPNIID 248
Cdd:pfam19279 44 RVTVDGEVREFSA-ALVA-VANSGYYGGGMRIAPDARVDDGLLDVVVIEAAsrrtllRLLPKVYDGrhVRLPQ--VEVLR 119
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90 100 110
....*....|....*....|....*....|....*...
gi 490240393 249 GVSswFEITAPHEMTFNLDGEPLTGKTFRMELLPAALR 286
Cdd:pfam19279 120 GRE--VRIEADRPLPAGADGEVLGPLPVRVEVLPGALR 155
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| PLN02958 |
PLN02958 |
diacylglycerol kinase/D-erythro-sphingosine kinase |
5-174 |
1.54e-04 |
|
diacylglycerol kinase/D-erythro-sphingosine kinase
Pssm-ID: 215517 [Multi-domain] Cd Length: 481 Bit Score: 42.93 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 5 PASLLIL----NGKGANEPSLREAVK-LLRDEGIDIHVRVTWEKGDAaRFIDEALKLN-VETVIAGGGDGTINEVATALV 78
Cdd:PLN02958 111 PKRLLVFvnpfGGKKSASKIFFDVVKpLLEDADIQLTIQETKYQLHA-KEVVRTMDLSkYDGIVCVSGDGILVEVVNGLL 189
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 79 ERDG-----DMALGILPLGTANDFATS----VGIPQELASALKLAIVGRDVAIDIARV-NDKTGFIN--MATGGFGTRIT 146
Cdd:PLN02958 190 EREDwktaiKLPIGMVPAGTGNGMAKSlldsVGEPCSATNAVLAIIRGHKCSLDVATIlQGETKFFSvlMLAWGLVADID 269
|
170 180
....*....|....*....|....*...
gi 490240393 147 TETpEKLKaALGGVSYLIHGLMRMDALK 174
Cdd:PLN02958 270 IES-EKYR-WMGSARLDFYGLQRILCLR 295
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