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Conserved domains on  [gi|490240393|ref|WP_004138656|]
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MULTISPECIES: lipid kinase YegS [Klebsiella]

Protein Classification

lipid kinase YegS( domain architecture ID 11486436)

lipid kinase YegS, a homolog to the mammalian diacylglycerol kinases, phosphorylates phosphatidylglycerol in vitro, but not diacylglycerol

EC:  2.7.1.-
Gene Ontology:  GO:0046872|GO:0001727|GO:0016310
PubMed:  17351295

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK13054 PRK13054
lipid kinase; Reviewed
3-297 0e+00

lipid kinase; Reviewed


:

Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 530.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   3 TFPASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDG 82
Cdd:PRK13054   2 TFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLEG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  83 DM--ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGV 160
Cdd:PRK13054  82 DArpALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGGV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 161 SYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTG-EELIPTLFSTLAN 239
Cdd:PRK13054 162 AYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPApQELLPTLLSTLTG 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490240393 240 P-ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLLR 297
Cdd:PRK13054 242 GsEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
 
Name Accession Description Interval E-value
PRK13054 PRK13054
lipid kinase; Reviewed
3-297 0e+00

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 530.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   3 TFPASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDG 82
Cdd:PRK13054   2 TFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLEG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  83 DM--ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGV 160
Cdd:PRK13054  82 DArpALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGGV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 161 SYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTG-EELIPTLFSTLAN 239
Cdd:PRK13054 162 AYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPApQELLPTLLSTLTG 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490240393 240 P-ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLLR 297
Cdd:PRK13054 242 GsEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
lip_kinase_YegS TIGR03702
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ...
6-296 4.06e-162

lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 163414  Cd Length: 293  Bit Score: 452.64  E-value: 4.06e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393    6 ASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDMA 85
Cdd:TIGR03702   1 KALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   86 --LGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGVSYL 163
Cdd:TIGR03702  81 paLGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  164 IHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEELIPTLFSTLANPENS 243
Cdd:TIGR03702 161 ITGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKN 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 490240393  244 PNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLL 296
Cdd:TIGR03702 241 PEFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
8-292 9.16e-90

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 269.03  E-value: 9.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   8 LLILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDgdM 84
Cdd:COG1597    6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG--P 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  85 ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLI 164
Cdd:COG1597   84 PLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRY-FLNVAGIGFDAEVVERANRALKRRLGKLAYVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 165 HGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGE---ELIPTLFSTLA-NP 240
Cdd:COG1597  163 AALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLsrlRLLRLLPRLLRgRH 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490240393 241 ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKT-FRMELLPAALRCRLPPD 292
Cdd:COG1597  243 LRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATpLEFEVLPGALRVLVPAD 295
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
8-127 2.02e-34

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 121.54  E-value: 2.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393    8 LLILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDM 84
Cdd:pfam00781   3 LVIVNpksGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLATRP 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 490240393   85 ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARV 127
Cdd:pfam00781  83 PLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
8-117 1.33e-16

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 74.26  E-value: 1.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393     8 LLILNGKGANEpSLREAVKLLRDEGIDIHVRVTWEKGDAARfIDEALKL-NVETVIAGGGDGTINEVATALVERDGDM-- 84
Cdd:smart00046   1 LVFVNPKSGGG-KGEKLLRKFRLLLNPRQVFDLTKKGPAVA-LVIFRDVpDFNRVLVCGGDGTVGWVLNALDKRELPLpe 78
                           90       100       110
                   ....*....|....*....|....*....|....
gi 490240393    85 -ALGILPLGTANDFATSVGIPQELASALKLAIVG 117
Cdd:smart00046  79 pPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLR 112
 
Name Accession Description Interval E-value
PRK13054 PRK13054
lipid kinase; Reviewed
3-297 0e+00

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 530.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   3 TFPASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDG 82
Cdd:PRK13054   2 TFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLEG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  83 DM--ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGV 160
Cdd:PRK13054  82 DArpALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGGV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 161 SYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTG-EELIPTLFSTLAN 239
Cdd:PRK13054 162 AYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPApQELLPTLLSTLTG 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490240393 240 P-ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLLR 297
Cdd:PRK13054 242 GsEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
lip_kinase_YegS TIGR03702
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ...
6-296 4.06e-162

lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 163414  Cd Length: 293  Bit Score: 452.64  E-value: 4.06e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393    6 ASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDMA 85
Cdd:TIGR03702   1 KALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   86 --LGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGVSYL 163
Cdd:TIGR03702  81 paLGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  164 IHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEELIPTLFSTLANPENS 243
Cdd:TIGR03702 161 ITGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKN 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 490240393  244 PNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPDCPLL 296
Cdd:TIGR03702 241 PEFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
1-289 6.22e-124

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 355.66  E-value: 6.22e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393    1 MSTFPASLLILNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVER 80
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   81 DGDMALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGV 160
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYCFINMAGGGFGTEITTETPEKLKAALGSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  161 SYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEELIPTLFSTLANP 240
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 490240393  241 E----NSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRL 289
Cdd:TIGR00147 241 EgkhtDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
8-292 9.16e-90

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 269.03  E-value: 9.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   8 LLILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDgdM 84
Cdd:COG1597    6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG--P 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  85 ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLI 164
Cdd:COG1597   84 PLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRY-FLNVAGIGFDAEVVERANRALKRRLGKLAYVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 165 HGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGE---ELIPTLFSTLA-NP 240
Cdd:COG1597  163 AALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLsrlRLLRLLPRLLRgRH 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490240393 241 ENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKT-FRMELLPAALRCRLPPD 292
Cdd:COG1597  243 LRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATpLEFEVLPGALRVLVPAD 295
PRK13337 PRK13337
putative lipid kinase; Reviewed
20-269 2.00e-46

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 158.29  E-value: 2.00e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  20 SLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDMALGILPLGTANDFAT 99
Cdd:PRK13337  20 NLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENRPKLGIIPVGTTNDFAR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 100 SVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIHGLMRMDALKPDRCE 179
Cdd:PRK13337 100 ALHVPRDIEKAADVIIEGHTVPVDIGKANNRY-FINIAGGGRLTELTYEVPSKLKTMLGQLAYYLKGIEMLPSLKATDVR 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 180 IRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTG---EELIPtlFSTLA---NPENSPNIIDGVSSW 253
Cdd:PRK13337 179 IEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKanlAELIH--IATLAlrgEHIKHPKVIYTKANR 256
                        250
                 ....*....|....*.
gi 490240393 254 FEITAPHEMTFNLDGE 269
Cdd:PRK13337 257 IKVSSFDKMQLNLDGE 272
PRK13057 PRK13057
lipid kinase;
8-292 2.80e-38

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 136.59  E-value: 2.80e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   8 LLILNGKGAN-EPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIdEALKLNVETVIAGGGDGTINEVATALVERDgdMAL 86
Cdd:PRK13057   1 LLLVNRHARSgRAALAAARAALEAAGLELVEPPAEDPDDLSEVI-EAYADGVDLVIVGGGDGTLNAAAPALVETG--LPL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  87 GILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIHG 166
Cdd:PRK13057  78 GILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHY-FFNVASLGLSAELARRLTKELKRRWGTLGYAIAA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 167 LMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLH---LRIFTGEELIPTLFSTLANPE-N 242
Cdd:PRK13057 157 LRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDlysLEVAHWWRLLALLPALRRGRHgE 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490240393 243 SPNIIDGVSSWFEITAPHEMTFNLDGEpLTGKT-FRMELLPAALRCRLPPD 292
Cdd:PRK13057 237 WPDVRAFRTTELELRTRKPRPINTDGE-LTTYTpAHFRVLPKALRVLAPPP 286
PRK13059 PRK13059
putative lipid kinase; Reviewed
38-287 5.01e-37

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 133.24  E-value: 5.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  38 RVTWEKGDAARF--IDEALKLnvetVIAGGGDGTINEVATALVERDGDMALGILPLGTANDFATSVGIPQELASALKLAI 115
Cdd:PRK13059  39 RISLEYDLKNAFkdIDESYKY----ILIAGGDGTVDNVVNAMKKLNIDLPIGILPVGTANDFAKFLGMPTDIGEACEQIL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 116 VGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIHGLMRMDALKPDRCEIRGENFHWHGDALVIG 195
Cdd:PRK13059 115 KSKPKKVDLGKINDKY-FINVASTGLFTDVSQKTDVNLKNTIGKLAYYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLML 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 196 IGNGRQAgGGQQLCPEALINDGLLHLRIFTG---EELIPTLFSTLANP--ENSPNIIDGVSSWFEITAPHEMTFNLDGEp 270
Cdd:PRK13059 194 VFNGQTA-GNFNLAYKAEVDDGLLDVIIIKAcpiIDLIPLFIKVLKGEhlEDVNGLIYFKTDKLEIESNEEIVTDIDGE- 271
                        250
                 ....*....|....*..
gi 490240393 271 ltgktfRMELLPAALRC 287
Cdd:PRK13059 272 ------RGPDFPLNIEC 282
PRK00861 PRK00861
putative lipid kinase; Reviewed
9-292 3.03e-36

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 131.28  E-value: 3.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   9 LILN---GKGANEPSLREAVKLLRDEgIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVErdGDMA 85
Cdd:PRK00861   7 LIFNpvaGQGNPEVDLALIRAILEPE-MDLDIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIG--TDIP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  86 LGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARVNDKTgFINMATGGFGTRITTETPEKLKAALGGVSYLIH 165
Cdd:PRK00861  84 LGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCNGQP-MILLAGIGFEAETVEEADREAKNRFGILAYILS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 166 GLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQ-----AGGGQQLCPEalinDGLLHLRIFTGE---ELIPT---LF 234
Cdd:PRK00861 163 GLQQLRELESFEVEIETEDQIITTNAVAVTVANAAPptsvlAQGPGAVIPD----DGLLDVTIVAPKnlaEAVAAsyhLL 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 235 ST--LANPENSPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPPD 292
Cdd:PRK00861 239 QTalQGNPAERDDIGYLRAKQVKITTDPPQKVVIDGEVVGTTPIEIECLPRSLKVFAPLQ 298
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
8-127 2.02e-34

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 121.54  E-value: 2.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393    8 LLILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVERDGDM 84
Cdd:pfam00781   3 LVIVNpksGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLATRP 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 490240393   85 ALGILPLGTANDFATSVGIPQELASALKLAIVGRDVAIDIARV 127
Cdd:pfam00781  83 PLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
PRK13055 PRK13055
putative lipid kinase; Reviewed
9-269 6.38e-30

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 115.47  E-value: 6.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   9 LILN---GKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDE-ALKLNVETVIAGGGDGTINEVATALVERDGDM 84
Cdd:PRK13055   7 LIYNptsGQEIMKKNVADILDILEQAGYETSAFQTTPEPNSAKNEAKrAAEAGFDLIIAAGGDGTINEVVNGIAPLEKRP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  85 ALGILPLGTANDFATSVGIPQ-ELASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKLKAALGGVSYL 163
Cdd:PRK13055  87 KMAIIPAGTTNDYARALKIPRdNPVEAAKVILKNQTIKMDIGRANEDKYFINIAAGGSLTELTYSVPSQLKSMFGYLAYL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 164 IHGLMRMDALKPDRCEIRGENFHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLLHLRIFTGEEL--IPTLFSTLANPE 241
Cdd:PRK13055 167 AKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLfeLLHLMALILNGG 246
                        250       260       270
                 ....*....|....*....|....*....|...
gi 490240393 242 ---NSPNIIDGVSSWFEIT--APHEMTFNLDGE 269
Cdd:PRK13055 247 khiDDPRVIYIKTSKLTIEplGDDRLMVNLDGE 279
PRK12361 PRK12361
hypothetical protein; Provisional
34-291 1.81e-17

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 82.36  E-value: 1.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  34 DIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVerDGDMALGILPLGTANDFA------TSVGIPqeL 107
Cdd:PRK12361 274 DLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELV--NTDITLGIIPLGTANALShalfglGSKLIP--V 349
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 108 ASALKLAIVGRDVAIDIARVNDKTGFINMATGGFGTRITTETPEKlKAALGGVSYLiHGLMR-MDALKP-------DRCE 179
Cdd:PRK12361 350 EQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRER-KNALGQLAYL-DGLWRaVNENETltltvtlDDAE 427
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393 180 IRGENFHwhgdALVigIGNGRQA------GGGQqlcPEalINDGLLHL-----------RIFTGEELIptlFSTLANPEN 242
Cdd:PRK12361 428 PQTISTH----SLV--VANAAPFtsllaqGGGE---PN--MTDGLLDItwldsggepgeQLLSLAELA---LSGLGKEPE 493
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 490240393 243 SPNIIDGVSSWFEITAPHEMTFNLDGEPLTGKTFRMELLPAALRCRLPP 291
Cdd:PRK12361 494 ANKVHHAHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQPASLKVFVPY 542
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
8-117 1.33e-16

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 74.26  E-value: 1.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393     8 LLILNGKGANEpSLREAVKLLRDEGIDIHVRVTWEKGDAARfIDEALKL-NVETVIAGGGDGTINEVATALVERDGDM-- 84
Cdd:smart00046   1 LVFVNPKSGGG-KGEKLLRKFRLLLNPRQVFDLTKKGPAVA-LVIFRDVpDFNRVLVCGGDGTVGWVLNALDKRELPLpe 78
                           90       100       110
                   ....*....|....*....|....*....|....
gi 490240393    85 -ALGILPLGTANDFATSVGIPQELASALKLAIVG 117
Cdd:smart00046  79 pPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLR 112
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
11-219 2.84e-16

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 77.52  E-value: 2.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  11 LNGKGANEPSLREAVKLLRDEGIDIHVRVTWEKGDAARFIDEALKLNVETVIAGGGDGTINEVATALVErdGDMALGILP 90
Cdd:PRK11914  18 LSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVISNALQVLAG--TDIPLGIIP 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  91 LGTANDFATSVGIPQELASALKLAIV-GRDVAIDIARVNDKTG----FINMATGGFGTRITTETpEKLKAALGGVSYLIH 165
Cdd:PRK11914  96 AGTGNDHAREFGIPTGDPEAAADVIVdGWTETVDLGRIQDDDGivkwFGTVAATGFDSLVTDRA-NRMRWPHGRMRYNLA 174
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490240393 166 GLMRMDALK--PDRCEIRGENfHWHGDALVIGIGNGRQAGGGQQLCPEALINDGLL 219
Cdd:PRK11914 175 MLAELSKLRplPFRLVLDGTE-EIVTDLTLAAFGNTRSYGGGMLICPNADHTDGLL 229
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
177-286 8.73e-05

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 42.18  E-value: 8.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  177 RCEIRGENFHWHGdALVIgIGNGRQAGGGQQLCPEALINDGLLHLRIFTGE------ELIPTLFST--LANPEnsPNIID 248
Cdd:pfam19279  44 RVTVDGEVREFSA-ALVA-VANSGYYGGGMRIAPDARVDDGLLDVVVIEAAsrrtllRLLPKVYDGrhVRLPQ--VEVLR 119
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 490240393  249 GVSswFEITAPHEMTFNLDGEPLTGKTFRMELLPAALR 286
Cdd:pfam19279 120 GRE--VRIEADRPLPAGADGEVLGPLPVRVEVLPGALR 155
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
5-174 1.54e-04

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 42.93  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393   5 PASLLIL----NGKGANEPSLREAVK-LLRDEGIDIHVRVTWEKGDAaRFIDEALKLN-VETVIAGGGDGTINEVATALV 78
Cdd:PLN02958 111 PKRLLVFvnpfGGKKSASKIFFDVVKpLLEDADIQLTIQETKYQLHA-KEVVRTMDLSkYDGIVCVSGDGILVEVVNGLL 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490240393  79 ERDG-----DMALGILPLGTANDFATS----VGIPQELASALKLAIVGRDVAIDIARV-NDKTGFIN--MATGGFGTRIT 146
Cdd:PLN02958 190 EREDwktaiKLPIGMVPAGTGNGMAKSlldsVGEPCSATNAVLAIIRGHKCSLDVATIlQGETKFFSvlMLAWGLVADID 269
                        170       180
                 ....*....|....*....|....*...
gi 490240393 147 TETpEKLKaALGGVSYLIHGLMRMDALK 174
Cdd:PLN02958 270 IES-EKYR-WMGSARLDFYGLQRILCLR 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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