|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
30-415 |
4.15e-93 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 286.38 E-value: 4.15e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGGLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17502 11 DQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIgavf 189
Cdd:cd17502 91 AIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 hssnkrsqhqidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiiplalfrnRSF 269
Cdd:cd17502 167 -----------------------------------------------------------------------------RTI 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 270 LLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTGMV 349
Cdd:cd17502 170 LLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAG 249
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 350 LLTRITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVAL 415
Cdd:cd17502 250 LLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
30-488 |
1.66e-65 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 216.29 E-value: 1.66e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:cd17503 11 DTTIVNVALPTIMGDLGaSLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIgav 188
Cdd:cd17503 91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 fhssnkrsqhqidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaePIIPLALFRNRS 268
Cdd:cd17503 168 --------------------------------------------------------------------PLLDLRLFKDRN 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 269 FLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGkYRLFPILGTLLGVTGM 348
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG-PRLLLLAGLLLLALGT 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 349 VLLTRITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHVLQSNL 428
Cdd:cd17503 259 LLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHH 338
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 429 QQLlpegavlppgMNPVAVQHLpadirldyLDAFGAAIHAAFLMAAGIMAVAFVLSWLLK 488
Cdd:cd17503 339 SRL----------SELLAQQVQ--------KQALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
30-431 |
4.84e-63 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 213.01 E-value: 4.84e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGG-LDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSsLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAV 188
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 FHSSNKRSQHQIDWLGAIYLSMALLCIILFTSEGGSvHAWNDPQLWCILAF-GIVGIIGFIYEERMAAEPIIPLALFRNR 267
Cdd:TIGR00711 177 LPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPE-RGWFDSNEILILSItGLVAIIAFVVWELTDDNPLVDLRLFKYR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 268 SFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTG 347
Cdd:TIGR00711 256 NFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGF 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 348 MVLLTRITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHVLQSN 427
Cdd:TIGR00711 336 YWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILTNRTQFH 415
|
....
gi 490246860 428 LQQL 431
Cdd:TIGR00711 416 HSQL 419
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-488 |
1.60e-59 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 200.09 E-value: 1.60e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGG-LDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:cd17321 11 DVTIVNVALPTIARDLGAsPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIgav 188
Cdd:cd17321 91 RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 fhssnkrsqhqidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiiplalfrnRS 268
Cdd:cd17321 168 ------------------------------------------------------------------------------RT 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 269 FLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGkYRLFPILGTLLGVTGM 348
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG-PRLVLVAGLLLTAVGL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 349 VLLTRITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHVLQSNL 428
Cdd:cd17321 249 LLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANL 328
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 429 QQLLPEGAVLPPGmnpvavqhlpadirldylDAFGAAIHAAFLMAAGIMAVAFVLSWLLK 488
Cdd:cd17321 329 GDSGVAALLSAAA------------------AAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
32-437 |
3.63e-53 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 187.45 E-value: 3.63e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELGGLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGL 111
Cdd:cd06179 15 TLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 112 QGLGGGGLmVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQ--HASWRWIFYINLPLGLFALLVIGAVF 189
Cdd:cd06179 95 IGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINAIFNALALILLFFFY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 H-------SSNKRSQH--QIDWLGAIYLSMALLCIILFTSEGGSVHAWNDPQLWCILAFGIVGIIGF-IYEERMAAEPI- 258
Cdd:cd06179 174 HppprpqlHGSSTRQKlkRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIAFgLYEWKGTKDGLl 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 259 IPLALFRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPI 338
Cdd:cd06179 254 PPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLV 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 339 LGTLLGVTGMVLLTRITIHSPLWQLyLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGA 418
Cdd:cd06179 334 AGFVLFTAFLALLALITPDNKALAI-AFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTS 412
|
410
....*....|....*....
gi 490246860 419 VFTHVLQSNLQQLLPEGAV 437
Cdd:cd06179 413 ILSNRLSKNLPARVAPAAL 431
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-411 |
4.90e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 145.12 E-value: 4.90e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 7 NPPVQSIRLLFSALLLVMLLSALDQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVA 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 86 IGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHA 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 166 SWRWIFYINLPLGLFALLVIGAVFHSSNKRSQHQIdwlgaiylsmallciilftseggsvhawndpqlwcilafgivgii 245
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARL--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 246 gfiyeermaaePIIPLALFRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGR 325
Cdd:COG2814 197 -----------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 326 IISRTGKYRLFpILGTLLGVTGMVLLtriTIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFR 405
Cdd:COG2814 266 LADRFGRRRLL-LIGLLLLALGLLLL---ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
....*.
gi 490246860 406 SIGGSI 411
Cdd:COG2814 342 FLGGPL 347
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-421 |
1.42e-36 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 138.86 E-value: 1.42e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 31 QTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17504 12 ETMLSPALPTIQREFGtSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 gLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIgavf 189
Cdd:cd17504 92 -ALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 hssnkrsqhqidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaePIIPLALFRNRSF 269
Cdd:cd17504 167 -------------------------------------------------------------------PLIDLRLLRRRNV 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 270 LLCSLIGFVIGMSLFGSVTFLPLYLQVVKEA----TPTEAGLQLIPLMGGLLLTSIISGRIISRTGkYRLFPILGTLLGV 345
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIARVG-PRRVLLIGLVISA 258
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 346 TGMVLLTriTIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFT 421
Cdd:cd17504 259 VGLLLLA--LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| MFS_efflux_LmrA |
NF000031 |
lincomycin efflux MFS transporter Lmr(A); |
30-419 |
3.16e-31 |
|
lincomycin efflux MFS transporter Lmr(A);
Pssm-ID: 411074 [Multi-domain] Cd Length: 484 Bit Score: 125.94 E-value: 3.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:NF000031 46 DVTVVNIALPAIRDSFHvDTRQLTWVVTGYTVVGGGLLMVGGRIADLFGRRRTLLFGAFLFGASSLAAGLAPNLELLVLA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIP-PANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGA 187
Cdd:NF000031 126 RFGQGAGEALSLPAAMSLIALLFPeTAARSKALSVWASVASVGLVLGFLLSGVITQLFSWRWIFLINIPLVSLVLVAVLL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 188 VFHSSNKRSQHQIDWLGAIYLSMALLCIILFTSEGGSVHAWNDPQLWCILAFGIVGiIGFIYEERMAAEPIIPLALFRNR 267
Cdd:NF000031 206 LVKKDETTARNPVDLPGALLFTAAPLLLIFGVIELGEDEPRLPLAVGSLLAAAVCA-AAFVAVERRTAHPLVPLTFFGNR 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 268 SFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLfPILGTLLGVTG 347
Cdd:NF000031 285 VRLVANGATVLLSAALSTSFFLLTMHLQEERDLSPIEAGLSFLPLALSLILASLLVPRLIERIGTTGA-AVLGMALAALG 363
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246860 348 MVLLTRI-TIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAV 419
Cdd:NF000031 364 IGCFALLpSDNSLLTSVFPGMILLACGMATGLVALQNAALHAVTEADAGVASGVQRCADQLGGASGIAVYVSI 436
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
59-434 |
5.65e-29 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 119.72 E-value: 5.65e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 59 ILSSTIAVPlYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPANRGR 138
Cdd:cd17322 48 IVSAVSQPP-YAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGF 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 139 YQGLfggvFGLATVIGPLIGGFLVQ----HASWRW---IFYINLPLGlfALLVIGAVFHSSNKRSQH------------- 198
Cdd:cd17322 127 ASAI----PSLPYIITTWIGGNIAQaalpNSNWRWgygMWAIILPLS--SLPLVLCLLYMQRKARKDgeikelknqetee 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 199 --------------QIDWLGAIYLSMALLCIIL-FTSEGGSVHAWNDPQLWCILAFGIVGIIGF-IYEERMAAEPIIPLA 262
Cdd:cd17322 201 qtgglsqnlvklfwKLDIFGVILLTAGLGLILVpLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFlLWEAKFAKYPFLPFR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 263 LFRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTL 342
Cdd:cd17322 281 LLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVP 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 343 LGVTGMVLLTRITIHSPLW-QLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFT 421
Cdd:cd17322 361 LYIVGMGLLIRYRGGSGSHgGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWT 440
|
410
....*....|...
gi 490246860 422 HVLQSNLQQLLPE 434
Cdd:cd17322 441 QTLPKKLLKNLPD 453
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
30-294 |
1.59e-28 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 114.52 E-value: 1.59e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:COG0477 29 DFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAV 188
Cdd:COG0477 109 RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 FHSSNKRSQHQIDWLGAIYLSMALLCIILFTSEGGSVHAWNDPQLWCILAFGIVGIIGFIYEERMAAEPIIPLALFRNRS 268
Cdd:COG0477 189 PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLL 268
|
250 260
....*....|....*....|....*.
gi 490246860 269 FLLCSLIGFVIGMSLFGSVTFLPLYL 294
Cdd:COG0477 269 LLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
31-422 |
2.44e-26 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 109.97 E-value: 2.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 31 QTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17474 15 VSIVDPILPAIAEALGaSPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHaSWRWIFYINLPLGLFALLVIgAVF 189
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAI-LFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 HSSNKRSQHQIDwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermAAEPIIPLALFRNRSF 269
Cdd:cd17474 173 LPEPKEKAKSSS----------------------------------------------------ATKLRDLKKALRGRGL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 270 LLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRtgKYRLFPILGTLLGVTGMV 349
Cdd:cd17474 201 LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK--RFGARRILVIGLLLYALS 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246860 350 LLTRITIHSpLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd17474 279 LLLLGFVPS-LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-423 |
1.56e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.66 E-value: 1.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 31 QTIVSTALPTIVGELGGLDKL-SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17325 12 YGIIIPILPLYAESLGASVAQiGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAVF 189
Cdd:cd17325 92 FLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 HSSNKRSQHQidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyEERMAAEPIIPLALFRNRSF 269
Cdd:cd17325 172 PEPRPPPNKR--------------------------------------------------AVSAARLRSGLRLLLRDRRL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 270 LLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLLGVTGMV 349
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI-LIGLLLSAVALL 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246860 350 LLTRITihsPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHV 423
Cdd:cd17325 281 LLPLAT---SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
30-343 |
9.10e-24 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 104.04 E-value: 9.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGGLD-KLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:PRK10504 25 DTTIVNTALPSMAQSLGESPlHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPpanRGRYQGLFGGVF---GLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:PRK10504 105 RVLQGVGGAMMVPVGRLTVMKIVP---REQYMAAMTFVTlpgQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 186 GAVFHSSNKRSQhQIDWLGAIYLS--MALLCIILFTSEGGSVHAWndpQLWCILAFGIVGIIGFIYEERMAAEPIIPLAL 263
Cdd:PRK10504 182 LMLMPNYTMQTR-RFDLSGFLLLAvgMATLTLALDGSKGLGLSPL---AIAGLVAVGVVALLLYLLHARNNNRALFSLKL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 264 FRNRSFLLcSLIGFVIGMSLFGSVTFL-PLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGkYRLFPILGTL 342
Cdd:PRK10504 258 FRTRTFSL-GLAGSFAGRIGSGMLPFMtPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFG-YRRVLVATTL 335
|
.
gi 490246860 343 L 343
Cdd:PRK10504 336 G 336
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-412 |
4.44e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.19 E-value: 4.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGGLDK--LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVL 107
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPteIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 108 MRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGA 187
Cdd:pfam07690 91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 188 VFHSSNKRSQHQidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyEERMAAEPIIPLALFRNR 267
Cdd:pfam07690 171 PRPPPESKRPKP--------------------------------------------------AEEARLSLIVAWKALLRD 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 268 SFLLCSLIGFVIGMSLFGSVTFLPLYlQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTG 347
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490246860 348 MVLLTRITIHSPLWQLYLFTgVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIG 412
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALL-LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-422 |
1.26e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.17 E-value: 1.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:COG2271 25 DRSNLSVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVigav 188
Cdd:COG2271 105 RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 fhssnkrsqhqidwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiiplalfrnrS 268
Cdd:COG2271 181 -------------------------------------------------------------------------------R 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 269 FLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTGM 348
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246860 349 VLLTRITihSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:COG2271 262 LLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
32-185 |
5.76e-21 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 94.56 E-value: 5.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRG 110
Cdd:cd17323 16 SIYSPALPQIAEDFHvSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490246860 111 LQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17323 96 LQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
31-420 |
2.46e-20 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 92.64 E-value: 2.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 31 QTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17320 15 IDMYLPALPAIARDLGaSASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlpLGLFALLVIGAVF 189
Cdd:cd17320 95 FLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF---LALLGLLLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 ------HSSNKRSQHQIDWLGAIylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiipLAL 263
Cdd:cd17320 172 lflpetLPEEKRKPLLSSLLRAY------------------------------------------------------KRV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 264 FRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLL 343
Cdd:cd17320 198 LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490246860 344 GVTGMVLL-TRITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPaQMYGVATSGVTLFRSIGGSIGVALFGAVF 420
Cdd:cd17320 278 LAAALVLLlAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
30-483 |
2.98e-20 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 93.64 E-value: 2.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGGL-DKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:PRK14995 21 DATVLHVAAPTLSMTLGASgNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIAT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAV-ADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGA 187
Cdd:PRK14995 101 RALLAIGAAMIVPATLAGIrATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTAR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 188 VFHSSNKRSQHQIDWLGAIYLSMALLciILFTSEGGSVHAWNDP-QLWCILAFGIVGIIGFIYEERMAAEPIIPLALFRN 266
Cdd:PRK14995 181 YVPRQAGRRDQPLNLGHALMLIVAIL--LLVYSAKTALKGFLSLwVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTH 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 267 RSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGkYRLFPILGTLLGVT 346
Cdd:PRK14995 259 RIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG-LRLVATGGMALSAL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 347 GMVLLTRITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH---- 422
Cdd:PRK14995 338 SFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRsysa 417
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246860 423 --VLQSNLQQLLPEGAVLPPGMNPVAVQHLPADIRLDYLDAFGAAIHAAFLMAAGIMAVAFVL 483
Cdd:PRK14995 418 siRLPAGLPAQLIEKASSSIGEAVQLANSLPPTLGQALLDAAKQAFIWSHSVVLSSAGSMLLL 480
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-422 |
1.58e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 1.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 38 LPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGG 116
Cdd:cd17324 22 LPDIARDFGvSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 117 GGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAVFHSSNKRS 196
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 197 QHQIDWLGAIylsmallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiipLALFRNRSFLLCSLIG 276
Cdd:cd17324 182 PGSLGLLSSL------------------------------------------------------LLLLRNPRLRLAYLIT 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 277 FVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLLGVTGMVLLTRITI 356
Cdd:cd17324 208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL-IALLLLAAALLLLTLLGPS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 357 HSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPaqmyGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd17324 287 PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR----GLASSLYLAAYNLGGALGAALGGLVLDH 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-422 |
3.94e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.09 E-value: 3.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:COG2223 20 VWYLWSVLAPPLAEEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlplglfallvigav 188
Cdd:COG2223 100 GLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI--------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 fhssnkrsqhqidwLGAIYLSMALLCIILFTSEGGSVHAwndpqlwcilafgivgiigfiyeeRMAAEPIIPLALFRNRS 268
Cdd:COG2223 165 --------------LGILLLVVAVLAWLFLRDPPAGAAA------------------------AAKASLRDQLEALRDPR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 269 FLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGL--QLIPLMGGLLltSIISGRIISRTGKYRLFPILGTLLGVT 346
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLlaALFALLGALG--RPLGGWLSDRIGGRRVLLIVFALMALG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 347 GMVLLtriTIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:COG2223 285 LLLLA---LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
32-423 |
4.28e-18 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 85.78 E-value: 4.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRG 110
Cdd:cd17476 15 GSVIVILPIIGDSFGtSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 111 LQGLGGGGLMVISMAAVADVIPPANRGRYQ-GLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlplglfallvigavf 189
Cdd:cd17476 95 LQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF---------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 hssnkrsqhqidwlgaiylsMALLCIILFTseggsvhawndpqlwcilafgivgiigfiyeermaaepiipLALFRNRSF 269
Cdd:cd17476 159 --------------------LAILAAIVAV-----------------------------------------AAIFWTSPS 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 270 LLCSLIGFVIGMSLFGSVTF-LPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKyRLFPILGTLLGVTGM 348
Cdd:cd17476 178 FIAVLLAVFLGWASFGIWVFyATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPP-SYIMAISMVAFLVGP 256
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 349 VLLTRITIHSPLWQLYLFTG-VLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHV 423
Cdd:cd17476 257 ILFATMPVHQTYWAQAFPAMiVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTVETSV 332
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-185 |
2.85e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 78.46 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 52 SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVI 131
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 490246860 132 PPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILL 134
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
54-422 |
3.99e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 82.64 E-value: 3.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 54 VVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPP 133
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 134 ANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAVfhSSNKRSQHQIDWLGAIYLSMall 213
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV--KDPPPVAAEEAEAGTRAFRR--- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 214 ciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiiplalFRNRSFLLCSLIGFVIGMSLFGSVTFLPLY 293
Cdd:cd17489 191 --------------------------------------------------LVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 294 lqvVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLLGVTGMVLLTRITihsPLWQLYLFTGVLGAG 373
Cdd:cd17489 221 ---AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVI-IPGLLLLALGLLLLSFAG---SPWMLLLAAVLYGLG 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 490246860 374 LGLVMQVL-VLAVQNAmPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd17489 294 FGLLFPALqALAVDLV-PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL 342
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
35-422 |
3.71e-14 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 75.09 E-value: 3.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 35 STALPTIVGELGGLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGsALCGLAQNMTQLVLMRGLQGL 114
Cdd:pfam06609 64 ASALPNILQDIGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVG-AIVGCTANKFNTLLAAMTLLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 115 GGGGLMVISMAAVADVIppANRGRYQGLFggVFGLATVI----GPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAVFH 190
Cdd:pfam06609 143 VAAGPAGASPLFIGELM--SNKTKFLGLL--IVSAPTIAmngaGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYH 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 191 SSNKRSQH-----------QIDWLGAIYLSMALLCIILFTSEGGSVHA-WNDPQLWCILAFGIVGIIGFIYEERMA--AE 256
Cdd:pfam06609 219 PPSFAQLHgkkarkrdelaKLDWIGIFLVIAGTSLFLLGVSWGGKPNNpWNSAKIIGLISSGAGSLVIFALYEVFGkpEQ 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 257 PIIPLALFRN-RSFLLCSLIGFVIGMSLFGSVTFLPlyLQVVKEATPTEAGLQLIPLMG-----GLLLTSIISGRIISRT 330
Cdd:pfam06609 299 PIIPPALFKDtRGFVCILIISSIMGAMHLCLTIIYP--QQVINIFGSSLKNWEETAWMSatasfGTGAGVMILGNLFHLI 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 331 GKYRLFPILGTL-----LGvtGMVLLTRITIHSPLwQLYLFTGVLgagLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFR 405
Cdd:pfam06609 377 RHIRWQILVGALwltafLG--AMSSINRDNKNAAI-ALSFFSGFV---VAWAQDITMLLVQFITTDEDLGVAFAVVAAAR 450
|
410
....*....|....*..
gi 490246860 406 SIGGSIGVALFGAVFTH 422
Cdd:pfam06609 451 PFAGSIFTAAFISLYSN 467
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-424 |
1.20e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.46 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGGLD-KLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSAsQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQH--ASWRWIFYINLPLGLFALLVIG 186
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 187 AVFHSSNKRSQHQIDwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyEERMAAEPIIPLALFRN 266
Cdd:cd06174 171 LVVPDPPESARAKNE------------------------------------------------EASSKSVLKLLKRVLKN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 267 RSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVT 346
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490246860 347 GMVLLtriTIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHVL 424
Cdd:cd06174 283 GLALL---LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
56-365 |
2.45e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 71.65 E-value: 2.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 56 TAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPAN 135
Cdd:TIGR00710 47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 136 RGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlpLGLFALLVIGAVF------HSSNKRSQHQIDWLGAiyls 209
Cdd:TIGR00710 127 LSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF---LSLAGILLSALIFfilpetLPYEARIQISTYFETF---- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 210 mallciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiipLALFRNRSFLLCSLIGFVIGMSLFGSVTF 289
Cdd:TIGR00710 200 ---------------------------------------------------LLLLKSKMFWGYALIYGASFGGFFAFFSG 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 290 LPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTGMVLLTRITIHSPLWQLYL 365
Cdd:TIGR00710 229 APFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMII 304
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-422 |
3.94e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.68 E-value: 3.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGgLDK--LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVL 107
Cdd:cd17319 18 DRVNISVAAPTIMKDLG-LSPtqYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 108 MRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlplglfallviga 187
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII-------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 188 vfhssnkrsqhqidwlgaiylsmallciilftseggsvhawndpqlwcilaFGIVGIIgfiyeermaaepIIPLALFRNR 267
Cdd:cd17319 163 ---------------------------------------------------EGLLGLL------------LAVLWWFYLR 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 268 SFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISR--TGKYRLFPILGTLLGV 345
Cdd:cd17319 180 QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAA 259
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490246860 346 TGMVLLTRITihsPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd17319 260 VGLLLAYLTT---SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDA 333
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-185 |
5.48e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.30 E-value: 5.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELGGLD--KLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17325 216 GALEPFLPLYAAELGGLSpaQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL 295
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17325 296 ALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
32-185 |
1.99e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 68.37 E-value: 1.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELGGLDKLSWVV----TAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVL 107
Cdd:cd17330 13 GIVFPVLPFYVREFNKLGASGYYVgllqSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490246860 108 MRGLQGLGGGGLMVISmAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17330 93 ARFLDGLTGGNVSVAQ-AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
32-408 |
3.85e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.60 E-value: 3.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELGGLDKL--SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17473 16 AAIAPALPAIAQHFVPNSELlvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHaSWRWIFYINLPLGLFALLVIGAVF 189
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 190 HSSNKRSQHqidwlgaiylsmallciilftseGGSVHAWNDPQLWcilafgivgiigfiyeermaaepiiplalfrnRSF 269
Cdd:cd17473 175 EPARKSKSA-----------------------ASPGAATAAALPW--------------------------------KRV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 270 LLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPIlGTLLGVTGMV 349
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI-GFALMALGFL 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490246860 350 LltrITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIG 408
Cdd:cd17473 279 L---LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-192 |
3.23e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.07 E-value: 3.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGgLDKLS--WVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVL 107
Cdd:TIGR00895 32 DLAAMGFAAPAISAEWG-LDPVQlgFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 108 MRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGA 187
Cdd:TIGR00895 111 LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMR 190
|
....*
gi 490246860 188 VFHSS 192
Cdd:TIGR00895 191 FLPES 195
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
37-189 |
6.39e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 63.78 E-value: 6.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 37 ALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLG 115
Cdd:PRK11102 13 ALPVIAADFGvSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246860 116 GGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlpLGLFALLVIGAVF 189
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAILAAALVF 163
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-423 |
1.04e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.33 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 51 LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMViSMAAVADV 130
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDV-AANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 131 IPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQH---ASWRWIFYInlpLGLFALLVIGAVFHSSNKRSQHQidwlgaiy 207
Cdd:COG0738 124 LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLI---LAVLLLLLALLFLRSKLPEIEEE-------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 208 lsmallciilftseggsvhawndpqlwcilafgivgiigfiyEERMAAEPIIPLALFRNRSFLLCSLIGFVIGMSLFGSV 287
Cdd:COG0738 193 ------------------------------------------EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 288 TFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLLGVTGMVLLtrITIHSPLWQLYLFT 367
Cdd:COG0738 231 DWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RLSALLAAVGLLLA--LLAPGPWLALIGLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490246860 368 GVlGAGLGLVMQVLVLAVQNAMPAQMyGVATSGVTLFRSIGGSIGVALFGAVFTHV 423
Cdd:COG0738 308 LV-GLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAF 361
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
56-188 |
5.93e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.10 E-value: 5.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 56 TAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPAN 135
Cdd:cd17328 41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 490246860 136 RGRYQGLFGGVFGLATVIGPLIGGFLVQHA-SWRWIFYINLPLGLFALLVIGAV 188
Cdd:cd17328 121 RTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
30-187 |
1.07e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.91 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGgLDK--LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVL 107
Cdd:cd17365 14 DLAVMGFVAPALAQDWG-LSPaqLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 108 MRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGA 187
Cdd:cd17365 93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRG 172
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
38-195 |
1.13e-09 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 59.96 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 38 LPTIVGELGGLDK-----LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQ 112
Cdd:cd17388 22 LPTLLREFVGDSAdaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 113 GLGGGGLMViSMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHaSWRWIFYINLPLGLFALLVIGAVFHSS 192
Cdd:cd17388 102 GITGATGAV-AAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLFVLPES 179
|
...
gi 490246860 193 NKR 195
Cdd:cd17388 180 LPP 182
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
69-199 |
2.03e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.15 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 69 YGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMaaVADVIPPANRGRYQGLFGGVFG 148
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMAL--LADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490246860 149 LATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAVFHSSNKRSQHQ 199
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS 180
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
67-164 |
3.29e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 58.39 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 67 PLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMvISMAAVADVIPPANRGRYQGLFGGV 146
Cdd:cd17390 49 PLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRVLGRFNAA 127
|
90
....*....|....*...
gi 490246860 147 FGLATVIGPLIGGFLVQH 164
Cdd:cd17390 128 SSLGFILGPVVGGHLAET 145
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
68-184 |
3.45e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.38 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 68 LYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVF 147
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGW 134
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 490246860 148 GLATVIGPLIGGFLVQHAS----WRWIFYINLPLGLFALLV 184
Cdd:cd17316 135 ALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLALLL 175
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
68-184 |
1.00e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.31 E-value: 1.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 68 LYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVF 147
Cdd:cd17371 53 LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGW 132
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 490246860 148 ----GLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLV 184
Cdd:cd17371 133 avgwLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFI 173
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
32-422 |
1.35e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.81 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRG 110
Cdd:COG2807 35 TSVGPLLPEIRADLGlSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 111 LQGLGGGGLMVISMAAVADVIpPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAVFH 190
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 191 SSNKRSQHQidwlgaiylsmallciilfTSEGGSVHAWNDPQLWCILAFgivgiigfiyeermaaepiiplalfrnrsFL 270
Cdd:COG2807 194 RRPAAAAAA-------------------PAAASLRSLWRSPLAWLLTLF-----------------------------FG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 271 LCSLIGFVIgmslfgsVTFLPLYLQvVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTGMVL 350
Cdd:COG2807 226 LQSLLYYAV-------VAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLG 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246860 351 LtritIHSPLWQLYLFTGVLGAGLGLVM-QVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:COG2807 298 L----LLAPGSLPWLWAVLLGLGQGGLFpLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDA 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
237-423 |
1.81e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 237 LAFGIVGIIGFIY------EERMAAEPIIPL-----ALFRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEA 305
Cdd:COG2211 187 LIFAVLGLLAFLLtffgtkERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALV 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 306 GLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLLGVTGMVLLTrITIHSPLWQLYLFTGVLGAGLGLVMQVLVLAV 385
Cdd:COG2211 267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAF-IIGLLLAALGLLLLF-FLGPGNLWLLLVLAALAGIGLGAILVLPWAML 344
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 490246860 386 QNAMPAQMY-------GVATSGVTLFRSIGGSIGVALFGAVFTHV 423
Cdd:COG2211 345 ADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
30-419 |
2.22e-08 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 56.19 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:TIGR00893 9 DRANLSFAAPMLQEDLGlSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYIL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVIGAV 188
Cdd:TIGR00893 89 RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLKF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 189 FHSSNKRSqhqidwlgaiylsmallciilftseggsvhAWNDPQLWCIlafgIVGIIGFIYEERMAAEPIIP--LALFRN 266
Cdd:TIGR00893 169 IPDPPQKA------------------------------KWLTEEEKYI----VVGGLLAEQQGKGPSTPKKYqiKELLKD 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 267 RSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLM----GGLLLTSIISGRIISRTGKY---RLFPIL 339
Cdd:TIGR00893 215 RRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGivgfIGMILGGRLSDLLLRRGKSLvfaRKTAII 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 340 GTLLGVTGMVLLTRITIhsplwQLYLFTGVLGAGLGLVMQVLVLAV-QNAMPAQMYGVATSGVTLFRSIGGSIGVALFGA 418
Cdd:TIGR00893 295 AGLVLSLLMFATNYVNI-----PYAALALVALGFFGLGAGAIGWALiSDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGA 369
|
.
gi 490246860 419 V 419
Cdd:TIGR00893 370 I 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-422 |
1.13e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELGGLD-KLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLA-----QNMTQL 105
Cdd:cd06173 16 WIFTVALPWLVLQLTGSAlLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 106 VLMRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 186 GAVFHSSNKRSQHQIDWLGAIylsmallciilftSEGGSVHAWNDPQLWcilafgivgiigfiyeermaaepiiplalfr 265
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRD-------------LREGLRYLRRSPLLR------------------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 266 nRSFLLCSLIGFVIGMslfgSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGV 345
Cdd:cd06173 212 -LLLLALALFALLGGA----LTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490246860 346 TGMVLltriTIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd06173 287 ALLVL----GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
51-382 |
1.17e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 53.79 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 51 LSWV---VTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAV 127
Cdd:PRK15402 47 AEWVptsMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAI 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 128 ADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYinlplgLFALLVIgavfhssnkrsqhqIDWLGaIY 207
Cdd:PRK15402 127 QESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFV------LFAALAA--------------LSFFG-LW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 208 LSMALLCiilfTSEGGSVHawndpqlwcilafgiVGIIGFIYeermaaepiipLALFRNRSFLLCSL-IGFViGMSLFGS 286
Cdd:PRK15402 186 RAMPETA----GRVGEKLS---------------LKELGRDY-----------KLVLKNRRFVAGALaLGLV-SLPLLAW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 287 VTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLLGVTGMVLLTRITIHSPLWQLYLF 366
Cdd:PRK15402 235 IALSPVILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLI-RMGLWPMVAGLLLAALATVISSHAYLWLT 313
|
330
....*....|....*...
gi 490246860 367 TG--VLGAGLGLVMQVLV 382
Cdd:PRK15402 314 AGlsLYAFGIGLANAGLY 331
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
30-182 |
2.64e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 53.16 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLM 108
Cdd:PRK03893 35 DFVLITLVLTEVQGEFGlTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIA 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246860 109 RGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFAL 182
Cdd:PRK03893 115 RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFAL 188
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
54-185 |
4.75e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 4.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 54 VVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPP 133
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 490246860 134 ANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
30-185 |
7.23e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 51.42 E-value: 7.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELG-GLDKL--SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLV 106
Cdd:cd17315 12 DLGVINGALLYIAKDLGfGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 107 LMRGLQGLGGGGLMVISMAAVADVIPPANRGRYqglfGGVFGLATVIGPLIGGFL------VQHASWRWIFYINLPLGLF 180
Cdd:cd17315 92 VGRFLLGLGVGLASVLVPLYISEIAPAKIRGAL----GTLNQLMITFGILLAYLLglalslSPPGWWRLMFALAAVPALL 167
|
....*
gi 490246860 181 ALLVI 185
Cdd:cd17315 168 QLLLM 172
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
30-171 |
9.91e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 50.73 E-value: 9.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 30 DQTIVSTALPTIVGELGGLDKLSW----VVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQL 105
Cdd:cd17360 12 DTGVISGALLYIKDDLGEVVLSTGwqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246860 106 VLMRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLF-----GGVFgLATVIGpliGGFLVQHASWRWIF 171
Cdd:cd17360 92 IVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINvlfitGGQF-VAYVIN---GAFSYLPGGWRWML 158
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
34-185 |
1.61e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 50.35 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 34 VSTALPTIVGELG-GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQ 112
Cdd:PRK11551 34 AGVAAPRMAQEFGlDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLT 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490246860 113 GLGGGGLMVISMAAVADVIPPANRGR-----YQGL-FGGVfgLATVIGPLIGGflvqHASWRWIFYINlplGLFALLVI 185
Cdd:PRK11551 114 GVGLGGALPNLIALTSEAVGPRLRGTavslmYCGVpFGGA--LASVIGVLAAG----DAAWRHIFYVG---GVGPLLLV 183
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
53-171 |
4.38e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 48.72 E-value: 4.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 53 WVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIP 132
Cdd:cd17359 40 LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAP 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 490246860 133 PANRGRYQGL--FGGVFGLATV------IGPLIGGFLVQHASWRWIF 171
Cdd:cd17359 120 AEIRGRLVSLnqLMIVFGQLLAyivnylIANAGGADWLGAEGWRWML 166
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-423 |
5.59e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.32 E-value: 5.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 31 QTIVSTALPTIVGELGGLDKL-SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMr 109
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQaGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 glqglggggLMVISM---------AAVADVIPPANRGRYQGLF--GGVFGLAtvIGPLIGGFLVQhaswRWIFYINLPLG 178
Cdd:cd17478 91 ---------VALAGIgsaafhpegARLASQAAGGRRGLAMSIFsvGGNLGFA--LGPLIAAALVA----LFGGLGLLILL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 179 LFALLVIGAVFHSSNKRSQHQIdwlgaiylsmallciilftseggsvhawndpqlwcilafgivgiigfiyEERMAAEPI 258
Cdd:cd17478 156 IIPGLAVALLLLRLRPLKKPEA-------------------------------------------------KKAAAKSSA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 259 IPLALFRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLqVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLfpI 338
Cdd:cd17478 187 RSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV--I 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 339 LGTLLGVTGMVLLtriTIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMyGVAtSGVTLFRSIG-GSIGVALFG 417
Cdd:cd17478 264 IASLLLAAPFLLL---FLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLA-SGLMMGLSFGlGGIGAPVLG 338
|
....*.
gi 490246860 418 AVFTHV 423
Cdd:cd17478 339 ALADAF 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-422 |
6.05e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.42 E-value: 6.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 51 LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISM-AAVAD 129
Cdd:cd17355 40 ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 130 VIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlpLGLFALLVIGAVfhssnkrsqhqidwlgaiyls 209
Cdd:cd17355 120 WWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV---LALLALLVLVPV--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 210 mALLCIILFTSEGGSVHAWNDPQLWcilafgivgiigfiyeermaaePIIPLALFRNRSFLLCSLIGFVIGMSLFGSVTF 289
Cdd:cd17355 176 -LLLLRRRPADLALRAYDDASPASP----------------------GSTLKEALRSASFWLLALAFFLCGFAVVGLIVH 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 290 LPLYLqVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLfpiLGTLLGVTGMVLLTRITIHSPLWQLYLFTGV 369
Cdd:cd17355 233 LVPYL-ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRL---LAASYALRALGLALLLLLPFPPLALLLFAAL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490246860 370 LGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd17355 309 FGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-213 |
6.90e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 48.09 E-value: 6.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 36 TALPTIVGELGGLD-KLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGL 114
Cdd:PRK10473 24 VGLPRIAADLNASEaQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 115 GGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFY----INLPLGLFALLVI----- 185
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYtmaaMGILVLLLSLFILketrp 183
|
170 180
....*....|....*....|....*...
gi 490246860 186 GAVFHSSNKRSQHQIDWLGAIYLSMALL 213
Cdd:PRK10473 184 ARAPAASSKPRENSESLLNRFFLSRLVI 211
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
64-189 |
1.46e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 47.27 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 64 IAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMvISMAAVADVIPPANRGRYQGLF 143
Cdd:cd17389 79 LSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPKKRSKGMALI 157
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 490246860 144 GGVFGLATVIGPLIGG-FLVQHASWRWIFYINLPLGLFALLVIGAVF 189
Cdd:cd17389 158 GVAFSLGFIIGPMIGAyFASFTRSLGEVFFSMPALFALVLALADLLF 204
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
34-184 |
1.74e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 34 VSTALPTIVGELGGL--DKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGL 111
Cdd:cd17329 219 LESTLPVYVVEILGLgeSLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIV 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246860 112 QGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLV 184
Cdd:cd17329 299 LTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
51-162 |
1.81e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 51 LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQ--NMTQLVLMRGLQGLGGGGLMVISMAAVA 128
Cdd:COG2211 266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLA 345
|
90 100 110
....*....|....*....|....*....|....*..
gi 490246860 129 DVIPPA---NRGRYQGLFGGVFGLATVIGPLIGGFLV 162
Cdd:COG2211 346 DVVDYDewkTGRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
32-184 |
2.76e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.45 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELG-----GLDKLSWVV-TAYILSSTIAVPLYGKFGDLFGRKIVL-QVAIGLFLVgSALCGLAQNMTQ 104
Cdd:PRK09874 31 SLVMPFLPLYVEQLGvtghsALNMWSGLVfSITFLFSAIASPFWGGLADRKGRKIMLlRSALGMGIV-MVLMGLAQNIWQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 105 LVLMRgLQGLGGGGLMVISMAAVADVIPPANRGRYQGLF--GGVFGlaTVIGPLIGGFLVQHASWRWIFYINLPLGLFAL 182
Cdd:PRK09874 110 FLILR-ALLGLLGGFVPNANALIATQVPRNKSGWALGTLstGGVSG--ALLGPLAGGLLADSYGLRPVFFITASVLFLCF 186
|
..
gi 490246860 183 LV 184
Cdd:PRK09874 187 LV 188
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
68-199 |
5.38e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 45.65 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 68 LYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPanrGRYQGLFGGVF 147
Cdd:PRK11043 60 LWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPA---QKANRVFATIM 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 490246860 148 ---GLATVIGPLIGGFLVQHASWRWIFYINLPLGLfaLLVIGAVFHSSNKRSQHQ 199
Cdd:PRK11043 137 plvALSPALAPLLGAWLLNHFGWQAIFATLFAITL--LLILPTLRLKPSKKARKQ 189
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
38-173 |
8.22e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 8.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 38 LPTIVGELGGLDKLS---W---VVTAYILSSTIAVPLYGKFGDLFGRK-IVLQVAIGLFLVGSALcGLAQNMTQLVLMRG 110
Cdd:cd17391 19 LPLYIEQLGVTSGGLvelWsglAFSSTFLVSAIFSPIWGRLADRYGRKpMLLRASLGMAIVIGLM-AFVTNVWQLLILRL 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246860 111 LQGLGGGGLMViSMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYI 173
Cdd:cd17391 98 LQGVFSGYVPN-ATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
34-198 |
8.64e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.87 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 34 VSTALPTIVGELGGLDKL--SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQ-NMTQLVLMRG 110
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAAtaGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 111 LQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHA-SWRWIFYINLPLGLFALLVIGAVF 189
Cdd:COG2223 304 LLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
....*....
gi 490246860 190 HSSNKRSQH 198
Cdd:COG2223 384 RRPRRAAAA 392
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-185 |
8.74e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 8.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 54 VVTAYILSSTIAVPLYGKFGDLFG--RKIVLQVAIGLFLVgsALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVI 131
Cdd:cd17391 245 VFSATGVSSLLSAPRLGKLGDRIGhhRILLGALLASALLY--IPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 490246860 132 PPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
35-184 |
9.38e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.01 E-value: 9.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 35 STALPTIVGELGGLDKLSWVV----TAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRG 110
Cdd:TIGR00898 109 DTFSSTIVTEWDLVCEDAWKVdltqSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRL 188
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490246860 111 LQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIgGFLVQHasWRWI-FYINLPLGLFALLV 184
Cdd:TIGR00898 189 LVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIPD--WRWLqLAVSLPTFLFFLLS 260
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
52-422 |
9.63e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 9.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 52 SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVI 131
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 132 PPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHaSWRWIFyinlplglfallvigavfhssnkrsqhqidWLGAIYLSMA 211
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLF------------------------------LAAAVLFLLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 212 LLciilftseggsvhawndpqlwcILAFGIVGIIGFIYEERMAAEPIIPLALFRNRSFLLCSLIGFVIGMSLFGSVTFLP 291
Cdd:cd17329 167 AL----------------------VLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 292 LYLQVVKEATPTEAGLqLIPLMGglLLTSIISGRIISRTGKYRLFPIL--GTLLGVTGMVLLTRITIhspLWQLYLFTGV 369
Cdd:cd17329 225 VYVVEILGLGESLLGL-LLALNA--LLIVLLQFPVARLVERFRLRKILmiGILLFAIGFAVLAFANT---LAVLILAMIV 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490246860 370 LGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTH 422
Cdd:cd17329 299 LTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
52-189 |
1.05e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.57 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 52 SWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLA---QNMTQLVLMRGLQGLGGGGLMVISMAAVA 128
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490246860 129 DVIPPANRGRyqglFGGVFGLATVIGPLIGGFL-------VQHASWRWIFYINLPLGLfaLLVIGAVF 189
Cdd:pfam00083 129 EIAPKKLRGA----LGSLYQLAITFGILLAYIFglglnktSNSDGWRIPLGLQLVPAL--LLIIGLLF 190
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
264-423 |
4.47e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 264 FRNRSFLLCSLIGFVIGMSLFGSVTFLPLYLQVVkEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFpILGTLL 343
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-LLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 344 GVTGMVLLTritIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHV 423
Cdd:COG2814 85 FALGSLLCA---LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-190 |
7.42e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 7.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 59 ILSSTIAVPLYGKFgdlFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPANRGR 138
Cdd:cd17474 248 ALGSLFVGRLLKKR---FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 490246860 139 YQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlpLGLFALLVIGAVFH 190
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV---GAAIALAAAVLLAL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-184 |
1.67e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 31 QTIVSTALPTIVGELGGLDKLS--WVVTAYILSSTIAVPLYGKFGD-LFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVL 107
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVagLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLL 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490246860 108 MRGLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFL-VQHASWRWIFYINLPLGLFALLV 184
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
51-185 |
2.52e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 51 LSWVVTAYILSSTIAVPLYGKfgdLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADV 130
Cdd:cd17331 249 MSYAGVLGMVVQGLLVGPLTK---RFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKA 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 490246860 131 IPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17331 326 VPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYL 380
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
59-191 |
2.55e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 59 ILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPPANRGR 138
Cdd:cd17330 221 IAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGK 300
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 490246860 139 YQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlplgLFALLVIGAVFHS 191
Cdd:cd17330 301 AQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL-----AAGLLLIALFLLS 348
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
54-179 |
2.58e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 40.03 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 54 VVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADVIPP 133
Cdd:cd17362 44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPS 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 490246860 134 ANRGRYQGLFGGVFGLATVIGPLIGGFLVQ-HASWRWIFYINLPLGL 179
Cdd:cd17362 124 HIRGLLVSLKELFIVLGILLGYVSGYAFADvVGGWRYMYGLAAPPAL 170
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
273-423 |
2.97e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 273 SLIGFVIGMSLFGSVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTGKYRLFPILGTLLGVTGMVLLt 352
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL- 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246860 353 ritIHSPLWQLYLFTGVLGAGLGLVMQVLVLAVQNAMPAQMYGVATSGVTLFRSIGGSIGVALFGAVFTHV 423
Cdd:pfam07690 81 ---FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
32-198 |
3.77e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.51 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 32 TIVSTALPTIVGELGgldkLSWVVTAYiLSSTIAV------PLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQL 105
Cdd:cd17331 17 WLQQPVLPYLTKKLG----VDSVVFGY-LQTTFSVlqlvggPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPML 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 106 VLMRGLQGLGGGglMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYINLPLGLFALLVI 185
Cdd:cd17331 92 FLSRLPSVFMHA--MQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLV 169
|
170
....*....|...
gi 490246860 186 GAVFHSSNKRSQH 198
Cdd:cd17331 170 ILLIPSNTKSKRE 182
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
54-191 |
5.53e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 5.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 54 VVTAYILSSTIAVP---LYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAAVADV 130
Cdd:COG2270 276 LIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARL 355
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490246860 131 IPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHA-SWRWIFyinlpLGLFALLVIGAVFHS 191
Cdd:COG2270 356 IPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTgSQRLGI-----LSLIVFFVIGLVLLL 412
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-415 |
6.00e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 6.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 47 GLDKLSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGLQGLGGGGLMVISMAA 126
Cdd:cd17333 29 NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 127 VADVIPpANRGRYQGLFGGVFGLATVIGPLIGGFLV-QHASWRWIFYINLPLGLFALLVIGAVFHSSNKRSQHQIDWLGA 205
Cdd:cd17333 109 VGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 206 IYLSMAllciilftseggsvhawndpqlwcilafgivgiigfiyeermaaepiiplALFRNRSFLLCSLIGFVIGMSLFG 285
Cdd:cd17333 188 FSASAS--------------------------------------------------RLLRNPSIILGALALFLYVGAETA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 286 SVTFLPLYLQVVKEATPTEAGLQLIPLMGGLLLTSIISGRIISRTgKYRLFPILGTLLGVTGMVLLtrITIHSPLWQLYL 365
Cdd:cd17333 218 FSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI-KPHTLLVLSGSGALLGLLIL--LLAPTLVVGLVA 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 490246860 366 FtgvlgAGLGLVMQVLVLAVqNAMPAQMYGVATSGVTLFRSIGGSIGVAL 415
Cdd:cd17333 295 T-----ALLGLFMAALFPTI-LSLGISNLPYAKGKGTSVLLAAGSIGGAI 338
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
35-189 |
6.97e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 6.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 35 STALPTIVGELGGLD--KLSWVVTAYILSSTIAVPLYGKFGDLF---GRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMR 109
Cdd:cd17319 199 LTWLPTYLKQARGFSlkQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 110 GLQGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQH-ASWRWIFYInlpLGLFALLVIGAV 188
Cdd:cd17319 279 SLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLF---LAAVALLAALLV 355
|
.
gi 490246860 189 F 189
Cdd:cd17319 356 L 356
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
263-371 |
8.15e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 38.37 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 263 LFRNRSFLLCsLIGFVIGMSLFGSV-TFL-PLYLQVVKEATPTEAGLQLIPLMGGLLlTSIISGRIISRTGKYRLFPILG 340
Cdd:cd17398 222 LFKNKGFLLL-LITYGINTGVYYAIsTLLnQMVLEYFPNEEVNAGWIGLTLVIAGLV-GSVVAGIWLDKTKKYKETTIIV 299
|
90 100 110
....*....|....*....|....*....|..
gi 490246860 341 TLLGVTGMVLLTrITIHS-PLWQLYLFTGVLG 371
Cdd:cd17398 300 YILSFIGMVAFT-FTLDLgSIWVVFLTAGALG 330
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|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-189 |
9.22e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 9.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246860 34 VSTALPTIVGELGGLDK--LSWVVTAYILSSTIAVPLYGKFGDLFGRKIVLQVAIGLFLVGSALCGLAQNMTQLVLMRGL 111
Cdd:cd06173 227 LTVLLPLLAKEVLGGGAagYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFL 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490246860 112 QGLGGGGLMVISMAAVADVIPPANRGRYQGLFGGVFGLATVIGPLIGGFLVQHASWRWIFYInlpLGLFALLVIGAVF 189
Cdd:cd06173 307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL---AGALLLLAALLLL 381
|
|
| |
