|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-398 |
7.94e-107 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 319.12 E-value: 7.94e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 30 ISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLAL 109
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 110 AGSFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYgkGNVAWFVLAALL 189
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF--GGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 190 AIVVLSQISRWYAAQHRMNKGKPKPaIVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKfGLTVQNAQLHL 269
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAK-SSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 270 FAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELLPGRIG 349
Cdd:cd17478 237 SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 490249292 350 MVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIF 398
Cdd:cd17478 317 LASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-348 |
3.47e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 124.32 E-value: 3.47e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 17 PQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVG 96
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 97 MCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPY 175
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 176 GKGNVawFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLifskYFYMASISSYYTFYLM 255
Cdd:COG2814 162 GWRWV--FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLL----GFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 256 HKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWT-GILTVIIGFILASAFS 334
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLlLLALFLLGFGFGLLFP 315
|
330
....*....|....
gi 490249292 335 AILVYAQELLPGRI 348
Cdd:COG2814 316 LLQALVAELAPPEA 329
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-399 |
3.31e-30 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 119.20 E-value: 3.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 21 RTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFT 100
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 101 LCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGN 179
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 180 VawFVLAALLAIVVlsqisrwyaaqhrmnkgkpkpaivnplprkkVILAVGILLMLIFSKYFYMASISSYYTFYLMHKFG 259
Cdd:COG2271 166 A--FLILGLPGLLL-------------------------------ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 260 LTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKY---VIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAI 336
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490249292 337 LVYAQELLPGRI-GMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFL 399
Cdd:COG2271 293 WALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-406 |
5.46e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 105.35 E-value: 5.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 26 ILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLI 105
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 106 LLALAGSFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFV 184
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIAlVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 185 LAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFymaSISSYYTFYLMHKFGLTVQN 264
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI---GFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 265 AQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTG--ILTVIIGFILASAFSAILVYAQE 342
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLflVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490249292 343 LLPGR-IGMVSGLFFGFAFGMGGLGAAVLGLLADHT-SIDLVYKICAFLPLLGFLTIFLPDNRQKA 406
Cdd:COG2223 323 IFPTKnAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-398 |
1.85e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.66 E-value: 1.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 30 ISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLAL 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 110 AGSFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAAL 188
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 189 LAIVVLSQISRWYAAQHRMNKGKPKPA----IVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQN 264
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAssksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 265 AQLHLFAFLFAVAAGTVIGGPVGDK-IGRKYVIWGSILGVAPFTLVLPYASLEWTG-ILTVIIGFILASAFSAILVYAQE 342
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLlLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 490249292 343 LLPGRIGMVSGLFFGFAFGMGGLGAAVLG--LLADHTSIDLVYKICAFLPLLGFLTIF 398
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAgfLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-399 |
7.02e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 90.30 E-value: 7.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 21 RTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFT 100
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 101 LCGLILLALAGSFGMVLLAAALVGTGSSVF----HPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYG 176
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLdvaaNPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 177 KGNVAWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSkyfyMASISSYYTFYLMH 256
Cdd:COG0738 164 HLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGA----EGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 257 KFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIG-RKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSA 335
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490249292 336 ILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYkicaFLPLLGFLTIFL 399
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF----LVPLVCYLLILL 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-347 |
6.10e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.39 E-value: 6.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 30 ISLSHLLNDMIQSLILAIYPL-LQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLA 108
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 109 LAGSFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAA 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 188 LLAIVVLSQISRwYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQL 267
Cdd:pfam07690 161 SLLAAVLLLLPR-PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 268 HLFAFLFAVAAGTVIGGPVGDKIGRKYVIW----GSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQEL 343
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlallLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
....
gi 490249292 344 LPGR 347
Cdd:pfam07690 320 APKE 323
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-399 |
4.58e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.85 E-value: 4.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 30 ISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLAL 109
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 110 AGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKgnVAWFVLAAL 188
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGY--RAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 189 LAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVIL--AVGILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQ 266
Cdd:cd17325 159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRdrRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 267 LHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYA-SLEWTGILTVIIGFILASAFSAILVY-AQELL 344
Cdd:cd17325 239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAtSFWLLLLLLALLGLGLGLVFPATLALlADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490249292 345 PGRIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFL 399
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
49-377 |
1.39e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.91 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSS 128
Cdd:COG2807 42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 129 VFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYG-KGNVAWFVLAALLAIVVLSQISRwyaAQHRM 207
Cdd:COG2807 122 VGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPLLR---RRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 208 NKGKPKPAIVNPLPRKKVILAVGiLLMLIFSKYFY--MASISSYYtfylmHKFGLTVQNAQLHLFAFLFAVAAGTVIGGP 285
Cdd:COG2807 199 AAAAPAAASLRSLWRSPLAWLLT-LFFGLQSLLYYavVAWLPPIL-----RDAGLSAATAGLLLSLFQLAGIPGSLLVPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 286 VGDKIG-RKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELL--PGRIGMVSGLFFGFAFGM 362
Cdd:COG2807 273 LADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLL 352
|
330
....*....|....*
gi 490249292 363 GGLGAAVLGLLADHT 377
Cdd:COG2807 353 AALGPLLVGALHDAT 367
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-395 |
1.83e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 68.00 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 43 LILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAAL 122
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 123 VGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLA-ALLAIVVLSQISRW 200
Cdd:cd17489 94 HGIGWGAFTTAAATlVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVlALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 201 YAAQHrmnKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYfymASISSYYTFYLMHKFgltVQNAQLHLFAFLFAVAAGT 280
Cdd:cd17489 174 PPVAA---EEAEAGTRAFRRLVEKKVLPPALILFLASIAY---GAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 281 VIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGILT-VIIGFILASAFSAILVYAQELLP-GRIGMVSGLFFGF 358
Cdd:cd17489 245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAaVLYGLGFGLLFPALQALAVDLVPpHRRGAANGTFFIF 324
|
330 340 350
....*....|....*....|....*....|....*..
gi 490249292 359 AFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFL 395
Cdd:cd17489 325 FDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
32-399 |
7.07e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 66.19 E-value: 7.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 32 LSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAG 111
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 112 SFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAAL-LA 190
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIyLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 191 IVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQLHLF 270
Cdd:cd17333 163 LAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 271 AFLFAVAAGTVIGGPVGDKIG-RKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELLPGRIG 349
Cdd:cd17333 243 GFWVGITIGRLLGGPISRRIKpHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 490249292 350 MVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFL 399
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
49-400 |
7.64e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 66.17 E-value: 7.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDK----RSMPWSLpvgMCFTLCGLiLLALAGSFGMVLLAAALVG 124
Cdd:cd17371 23 PALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRfgrvRVLVITI---LLFAVFTL-LCGFAQNYWQLLILRALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 125 TGSSVFHPESSRVARMASGGRH-----GLAQSLFQVGGnfgssLGPLLAAVIIAPYGKGNVAW---FVLAALLAIVV--- 193
Cdd:cd17371 99 LGFGGEWAAGAALMAEYVPARHrgkalGYVQSGWAVGW-----LLATLLAALLFPLLPPEIAWrvlFLLGALPALLVlfi 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 194 ---LSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSkYFYMASISSYYTFYLMHKFGLTVQNAQLHLF 270
Cdd:cd17371 174 rrfVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGA-LGGYYGITTWLPSYLTGERGLSFEGSAGYLV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 271 AFLFAVAAGTVIGGPVGDKIGRKYVIW-GSILGVAPFTLVLPY-ASLEWTGILTVIIGFILASAFSAILVYAQELLPGRI 348
Cdd:cd17371 253 VTILGGFLGYLAGGFLADRIGRRNNFAlFALGSAISILLYFFLpLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAV 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490249292 349 -GMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKI-CAFLPLLGFLTIFLP 400
Cdd:cd17371 333 rATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVfAAVYYIAGLVLALLL 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
27-328 |
9.64e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.11 E-value: 9.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 27 LGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLIL 106
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 107 LALAGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFV- 184
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIApTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVt 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 185 -----LAALLAIVVLSQISRWYAAQHRMNKGKPKP--AIVNPLPRKKVIlavgILLMLIFSKYFYMASISSYYT-FYLMH 256
Cdd:cd17328 161 gvlgvLLAILLLLFVREPPRGAAEGGVMAKSTATSflADLKALAKNPSF----ILSTLGFTAVSFVTGALAFWApTFFLR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 257 KFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWG----------SILGVAPFTLVLPYASLEwTGILTVIIG 326
Cdd:cd17328 237 AFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTpradplvcavGLLAAAPFLFLALVLALS-NLLLAWVLL 315
|
..
gi 490249292 327 FI 328
Cdd:cd17328 316 FL 317
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-334 |
1.34e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.69 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 16 PPQKARTSFGILGAISLSHLLNDMIQSLILAIYPL-LQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDK------RS 88
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrtrwgRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 89 MPW----SLPVGMCFTLCGLI-LLALAGSFGMVLLAAALVGTGSSVFH-PESSRVARMASGGR-HGLAQSLFQVGGNFGS 161
Cdd:COG2211 81 RPWiligAIPLALSFVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEeRTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 162 SLGPLLAAVIIAPYGKGNVAWFVLAALL--AIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSK 239
Cdd:COG2211 161 LLASVLPPPLVAAFGGDAALGYRLTALIfaVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 240 YFYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYV-IWGSILGVAPFTL--VLPYASLE 316
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAfIIGLLLAALGLLLlfFLGPGNLW 320
|
330
....*....|....*...
gi 490249292 317 WTGILTVIIGFILASAFS 334
Cdd:COG2211 321 LLLVLAALAGIGLGAILV 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-395 |
1.77e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.95 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 32 LSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAG 111
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 112 SFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKgnVAWFVLAALLA 190
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRaIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGW--RAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 191 IVVLSQISRWYAAQHRMNKGKPKPAIVnpLPRKKVILAVGILLMLIFSKYFYMA---SISSYYTFYLMHKFGLTVQNAQL 267
Cdd:cd17475 161 ILAAVLFWLFYREPPAASAATESASTL--LRSLKEVLRNRDVWLIAIAGALLVApqfALLTFLLLFLHDHLGLSVVAAGA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 268 HLFAFLFAVAAGTVIGGPVGDKIG----RKYVIWGSILGVAPFTLV--LPYASLEWT-GILTVIIGFILASAFSAILVYA 340
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDRVFggrrRPVLVITAAIAAAALLVLslLSPGTPLWLlVLLLILLGLFAIGWNGLYLTLV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490249292 341 QELLP-GRIGMVSGLFFGFAFGMGGLGAAVLGLLADHT-SIDLVYKICAFLPLLGFL 395
Cdd:cd17475 319 AESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAAL 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
35-399 |
2.17e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.94 E-value: 2.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 35 LLNDMIQSLILAIYpLLQAEFSLTFVqiGMITLTFQLTSSLFQPVIGYITD----KRSMPWSLpVGMCFTLCGLILLALA 110
Cdd:cd06173 12 ALGDWIFTVALPWL-VLQLTGSALLV--GLVLAAFFLPFLLFSPFAGVLADrfdrRRLLILAD-LLRALLAAVLALLALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 111 GSFGMVLL--AAALVGTGSSVFHP-ESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWF-VLA 186
Cdd:cd06173 88 GSLSLWLLlvLAFLLGIASAFFGPaRQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAInALS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 187 ALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQ 266
Cdd:cd06173 168 FLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 267 LHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEW-TGILTVIIGFILASAFSAILVYAQELLP 345
Cdd:cd06173 248 LLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWlLLAALFLLGLAGGLFNVPLNTLLQLRVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490249292 346 GRI-GMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFL 399
Cdd:cd06173 328 DELrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-398 |
2.67e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.49 E-value: 2.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 43 LILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAAL 122
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 123 VGTGSSVFHPESSRVA-RMASGGRHGLAQSLFQVGGNFGSSLGPLLAAvIIAPYGKGNVAWFVLAALLAIVVLSQisrWY 201
Cdd:cd17324 97 AGLAHGGFWAIAAAYAaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAFLAIAVLALLAALLL---WR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 202 AAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTV 281
Cdd:cd17324 173 LLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 282 IGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGILTVII-GFILASAFSAILVYAQELLPGRIGMVSGLFFGFAF 360
Cdd:cd17324 253 LAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYN 332
|
330 340 350
....*....|....*....|....*....|....*...
gi 490249292 361 GMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIF 398
Cdd:cd17324 333 LGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-399 |
5.66e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 5.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 27 LGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLIL 106
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 107 LALAGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIiapygkGNVAW--- 182
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL------AAISWryp 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 183 FVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLP--RKKVILAVGILLMLIFSKYFymaSISSYYTFYLMHKFGL 260
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKalRGRGLLTFLVSAFLYFFLYF---AFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 261 TVQNAQLHLFAFLFAVAAGTVIGGP-VGDKIGRKYVIWGSILGVAPFTLVLPYA-SLEWTGILTVIIGFILASAFSAILV 338
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490249292 339 YAQELLPGRI-GMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGFLTIFL 399
Cdd:cd17474 312 LVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
29-336 |
1.00e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 59.86 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 29 AISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPV-GMCFTLCGLILL 107
Cdd:cd17370 3 LLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlGYGLSALAKPLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 108 ALAGSFGMVLLAAALVGTGSSVFHPesSR---VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIApYGKGNV---- 180
Cdd:cd17370 83 ALAGSWQLVLLLRILERLGKGIRTP--PRdalLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLY-LLGGNYrtif 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 181 AWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMAsissyytfYLMHKFGL 260
Cdd:cd17370 160 LLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI--------LRAQELGL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490249292 261 TVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASlewtGILTVIIGFILASAFSAI 336
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS----SLWLLLLGFILWGLYMGA 303
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
45-284 |
3.10e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.01 E-value: 3.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 45 LAIYplLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVG 124
Cdd:cd17329 22 MAIY--LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 125 TGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIApYGKGNVAWFVLAA--LLAIVVLSQISRWY 201
Cdd:cd17329 100 FGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLflLAALVLLFLLPETR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 202 AAQHRMNKGKPKPAIVNPLPRKKVIL--AVGILLMLIFskyfymASISSYYTFYLMHKFGLTVQnaqlhLFAFLFAVAAG 279
Cdd:cd17329 179 PKRRAAEKTEILRGYKIVLRDRAFLLflLASFLISLIY------FQLESTLPVYVVEILGLGES-----LLGLLLALNAL 247
|
....*
gi 490249292 280 TVIGG 284
Cdd:cd17329 248 LIVLL 252
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-399 |
5.85e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.11 E-value: 5.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSS 128
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 129 VFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGkgnvaW---FVLAALLAIVVlsqisrwyaaq 204
Cdd:cd17319 107 GFFPGAIKaLAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-----WrwaFIIEGLLGLLL----------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 205 hrmnkgkpkpAIVnplprkkVILAVGILLMLIFSKYFYMASISSYYTF---YLMHKFGLTVQNAQLHLFAFLFAVAAGTV 281
Cdd:cd17319 171 ----------AVL-------WWFYLRQVWGLALGYFGINYALYGLLTWlptYLKQARGFSLKQVGLLAAIPFLAGAIGMI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 282 IGGPVGDKI---GRKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAIL-VYAQELLPGR-IGMVSGLFF 356
Cdd:cd17319 234 LGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFwSLPADLLPGEaAATAGGLIN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490249292 357 GFAFGMGGLGAAVLGLLADHT-SIDLVYKICAFLPLLGFLTIFL 399
Cdd:cd17319 314 SGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVALLAALLVLL 357
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-378 |
9.84e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.53 E-value: 9.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMcfTLCGLILLALAGSFGMVLLAAALVGTG-- 126
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGL--ILCAIVNLFFGFSTSLWVMAALWALNGif 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 127 -SSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGkGNVAWFVLAALLAIVV------------ 193
Cdd:TIGR00881 97 qGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY-SWHWVFIVPGIIAIIVslicflllrdsp 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 194 ----LSQISRWY------AAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIfskYFYMASISSYYTFYLMHKFGLTVQ 263
Cdd:TIGR00881 176 qscgLPPAEEMPneepdgDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFV---YVVRTGILDWSPLYLTQEKGFSKE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 264 NAQLHLFAFLFAVAAGTVIGGPVGDKI--GRKYVI-----WGSILGVAPFTLVlPYASLEWTGILTVIIGFILASAFSAI 336
Cdd:TIGR00881 253 KASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLavffmALIIVSLLVYWLN-PAANPLMDLICLFALGFLVYGPQMLI 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490249292 337 LVYAQELLPGR-IGMVSGLFFGFAFGMGGLGAAVLGLLADHTS 378
Cdd:TIGR00881 332 GVIASELAPKKaAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-336 |
5.08e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.42 E-value: 5.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 39 MIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLL 118
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 119 AAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLSQI 197
Cdd:cd17503 90 FRILQGFGGGVLIPLAqTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 198 SRWYAAQHRMnkgkpkpaivnplprkkviLAVGILLMLIFSKYFYMASIssYYTFYLMHKFGLTVQNAQLHLFAFLFAVA 277
Cdd:cd17503 170 LDLRLFKDRN-------------------FTLGLLLSFLLGLGLFGAMF--LLPLYLQNVLGYSAFESGLVLAPGGLASA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490249292 278 AGTVIGGPVGDKIG-RKYVIWGSIL---GVAPFTLVLPYASLEWTGILTVIIGFILASAFSAI 336
Cdd:cd17503 229 ILSPLVGRLLDKFGpRLLLLAGLLLlalGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPL 291
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-339 |
6.11e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.07 E-value: 6.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAA-ALVGTGS 127
Cdd:cd17353 27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 128 SVFHPESSRVARMASGGRHGLAQSLfqVGGNFGssLGPLLAAVIIAPYGKGN----------VAWFVLAALLAIVVLSQI 197
Cdd:cd17353 107 GIGYITPVSTAVKWFPDKRGLATGI--VIAGFG--LGSLIFSPLIAYLINTVgvpttflilgIIFLIIIVIGAFLIRDPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 198 SRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFS-KYFYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAV 276
Cdd:cd17353 183 KGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFlNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFN 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490249292 277 AAGTVIGGPVGDKIGRK--YVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVY 339
Cdd:cd17353 263 GGGRPFWGWLSDKIGRKntLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPAL 327
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-348 |
9.03e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 9.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 27 LGAISLSHLLNDMIQSLILAIYPLLQAEFS--LTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGL 104
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 105 ILLALAGSFGMVLLAAALVGTGSSVFHP-ESSRVARMASGGRHGLAQSLFQVGGNFGSSLGpLLAAVIIAPYGKGNVAW- 182
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPgASTYVAEFAPSKRRGFALGLLQSGWALGALLA-ALVASLLIPLLSGDWGWr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 183 --FVLAALLAIVVLsqisrwyaaqhrmnkgkpkpaivnpLPRKKVILAVGILLMLIFSKYFymasISSYYTFYLMHKFGL 260
Cdd:cd17316 160 ilFLIGALPALLAL-------------------------LLRRRTLLLILLWFFISFGYYG----LTTFLPTYLQTVLGL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 261 TVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYA---SLEWTGILTVIIGFILASAFSAIL 337
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALY 290
|
330
....*....|.
gi 490249292 338 VYAQELLPGRI 348
Cdd:cd17316 291 AYLAELFPTEV 301
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
95-398 |
9.35e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 9.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 95 VGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSRVAR----MASGGRHGLAQSLFQVGGNFGSSLGPLLAAV 170
Cdd:cd17471 68 LALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAReyadRSSGRDATLFNSVLRAAFSLAWVIGPPLAFL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 171 IIAPYGKGNVawFVLAALLAIVVLSQISRWYAAQHR-MNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMASISsy 249
Cdd:cd17471 148 LLDVLGFTGL--FLLAALLYLVVALLVLFLLPSVKPpAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMP-- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 250 ytFYLMHKFGLTVQnaqlhLFAFLFAVAAGTVI-----GGPVGDKIG-RKYVIWGSILGVAPFTLVLpyaslewtgILTV 323
Cdd:cd17471 224 --LYVTNELGGSES-----WVGLLFGLAAALEIpimllAGLLAKRFGkRRLLLAGFLAGVLFYLGLA---------LATS 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 324 IIGFILASAFSAI---------LVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFLPLLGF 394
Cdd:cd17471 288 LWQLIALQLLNAIfigitaglgISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLAL 367
|
....
gi 490249292 395 LTIF 398
Cdd:cd17471 368 VLLL 371
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-336 |
1.28e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.94 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 32 LSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAG 111
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 112 -SFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSS----LGPLLAAVIIAP---YGKGNVAWF 183
Cdd:cd17341 86 sSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAvsqlLAPLIAGAIVFDggfVGWRNAFFV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 184 VLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVIlavgILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQ 263
Cdd:cd17341 166 PGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKNYRTW----ILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLV 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490249292 264 NAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYA-SLEWTGILTVIIGFILASAFSAI 336
Cdd:cd17341 242 TAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSlPTSGTNLVLFLALFVALGLGAGA 315
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
50-334 |
4.55e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 48.45 E-value: 4.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 50 LLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAG-SFGMVLLAAALVGTGSS 128
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 129 VFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSL-----GPLLAAVIIAPYGKGNVAW--------FVLAALLAIVVLS 195
Cdd:TIGR00886 107 SFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVaqfvmPPIIGSLIFGGGQPAHLAWgwafvivpAGILLLPALLIFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 196 QISRWYaaqhrmnKGKPKPAIVNPLPRKKVILAVGILLMLIFskyfYMAS------ISSYYTFYLMHKFGLTVQNAQLHL 269
Cdd:TIGR00886 187 VGADTP-------PGKPATGKLSFKEALKVFGNRHTWILALL----YSVTfgsflgVSSIFAMLFKDQFGLSKVQAGAYA 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490249292 270 FAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFS 334
Cdd:TIGR00886 256 SLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFA 320
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-337 |
1.33e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.80 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 52 QAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFH 131
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 132 PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFvlAALLAIVVLSQISRWyaaqhrmnkgk 211
Cdd:cd17330 106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV--AAALALLNLVLVLFF----------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 212 pkpaivnpLPRKKVILAVGILLMLIFskyfymASISSYYTFYLMHKFGLTVQNAQLHLFAF-LFAVAAGTVIGGPVGDKI 290
Cdd:cd17330 173 --------LPPLRRLLLVYFLIALAF------AGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRL 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 490249292 291 GRKYVIWGSILGVAPFTLVLPYAS-LEWTGILTVIIGFILASAFSAIL 337
Cdd:cd17330 239 GERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALS 286
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
219-399 |
1.40e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.89 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 219 PLPRKKVILAVGILLMLIFSKYFYMASISSYytfyLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWG 298
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPL----IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 299 SILGVAPFTLVLPYA-SLEWTGILTVIIGFILASAFSAILVYAQELLPG-RIGMVSGLFFGFAFGMGGLGAAVLGLLADH 376
Cdd:COG2814 81 GLLLFALGSLLCALApSLWLLLAARFLQGLGAGALFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|...
gi 490249292 377 TSIDLVYKICAFLPLLGFLTIFL 399
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-352 |
1.90e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 30 ISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITD----KRSMPWSLPVgmcFTLCGLi 105
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDrfgrKRVFLIGLAL---FGLASL- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 106 LLALAGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFV 184
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIGAAAIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 185 LAALLAIVVLSqisrwyaaqhrmnkgkpkpaivnplprkKVILAVGILLMLIFskyFYMASISSYYTFYLMHKFGLTVQN 264
Cdd:cd17321 157 VPIGLVALLLA----------------------------RTFSGAVLAAFLLG---AALGGLLFLLPLYLQGVLGYSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 265 AQLHLFAFLFAVAAGTVIGGPVGDKIG-RKYVIWGSIL---GVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYA 340
Cdd:cd17321 206 AGLALLPLALAMLVAAPLAGRLADRFGpRLVLVAGLLLtavGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
|
330
....*....|...
gi 490249292 341 QELLP-GRIGMVS 352
Cdd:cd17321 286 LSSVPkEKAGAAS 298
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-398 |
2.96e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.72 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 51 LQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGS-FGMVLLAAALVGTGSSV 129
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 130 FH-PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYG-KGNVAWFVLAALLAIVVLSQISRWYAAQHRM 207
Cdd:cd17355 109 LAaVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 208 NKGKPKPAIVNPLPRKKVILAVGILLMLI--FSKYFYMASISSYYTFYLMHkFGLTVQNAQLHLFAFLFAVAAGTVIGGP 285
Cdd:cd17355 189 RAYDDASPASPGSTLKEALRSASFWLLALafFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGW 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 286 VGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGILTVIIGFILAS----AFSAILVyAQELLPGRIGMVSGLFFGFAFG 361
Cdd:cd17355 268 LGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWgatvPLTAALA-ARYFGARSYGTLFGLVFAPHQL 346
|
330 340 350
....*....|....*....|....*....|....*...
gi 490249292 362 MGGLGAAVLGLLADHT-SIDLVYKICAFLPLLGFLTIF 398
Cdd:cd17355 347 GSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-403 |
4.30e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 4.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 232 LLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLP 311
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 312 YA-SLEWTGILTVIIGFILASAFSAILVYAQELLPG-RIGMVSGLFFGFAFGMGGLGAAVLGLLADHTSIDLVYKICAFL 389
Cdd:pfam07690 81 FAsSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|....
gi 490249292 390 PLLGFLTIFLPDNR 403
Cdd:pfam07690 161 SLLAAVLLLLPRPP 174
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-278 |
5.37e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.80 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 14 AAPPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSL 93
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 94 PVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVII 172
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGAlALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 173 APYGKGNVawFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYMASISSYYTF 252
Cdd:COG0477 163 AALGWRWI--FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260
....*....|....*....|....*.
gi 490249292 253 YLMHKFGLTVQNAQLHLFAFLFAVAA 278
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLL 266
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-194 |
5.94e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 5.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 50 LLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSV 129
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490249292 130 FHPE-SSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVL 194
Cdd:cd17473 303 LLPTlNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAI 368
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
140-348 |
6.57e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 44.59 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 140 MASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNV---AW---FVLAALLAIVVL---SQISRWYAAQHRMNKG 210
Cdd:cd17367 129 VAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMaawGWripFLLGGVLAVVVLwlrRGLEETESFEAIAESN 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 211 KPKPAIVNPLPRKKVILAVGILLMLIFSKYFYmaSISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKI 290
Cdd:cd17367 209 EASAGTLRELRRHPRELLLVVGLTAGGTLAFY--TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRI 286
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490249292 291 GRKYVIWGSILGVAPFT----LVLPYASLEWTGILTVIIGFILASAFSAIL-VYAQELLPGRI 348
Cdd:cd17367 287 GRRPLLLFFGIGGTLATvpllSALDHTDSPYTAFALVLVGLVFLSGYTSINaVVKAELFPTHV 349
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-194 |
8.67e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 8.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 48 YPLLQAEFSLTFVQIGMITLT---FQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVG 124
Cdd:cd17370 219 FAFLILRAQELGLSAALIPLLyalFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWG 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490249292 125 TGSSVFH-PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWF-VLAALLAIVVL 194
Cdd:cd17370 299 LYMGAQEsIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFsAVLALIALLLL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-345 |
1.07e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.27 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMItLTFQLTSSLFQP-VIGYITDK----RSMPWSLPVGMCFTLcgliLLALAGSFGMVLLAAALV 123
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFL-FSAGLIGMAFGAlFFGPLADRigrrRVLLWSILLFSVFTL----LCALATNVTQLLILRFLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 124 GTG-SSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYG------KGNVAWFVLAALLAIVV--- 193
Cdd:TIGR00895 116 GLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGwrslfyVGGIAPLLLLLLLMRFLpes 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 194 --LSQISRWYAAQHRMNKGKPK----PAIVNPLPRKKVILAVGILLMLIFSKY---------FYMASISSYY-----TFY 253
Cdd:TIGR00895 196 idFLVSKRPETVRRIVNAIAPQmqaeAQSALPEQKSTQGTKRSVFKALFQGKTaritvllwlLYFMLLVGVYfltnwLPK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 254 LMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSIL-GVAPFTLVLPYASLEWTGILTVIIGFILASA 332
Cdd:TIGR00895 276 LMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLgAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGG 355
|
330
....*....|...
gi 490249292 333 FSAILVYAQELLP 345
Cdd:TIGR00895 356 QSGLYALMALFYP 368
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
28-335 |
4.50e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 42.30 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 28 GAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVqiGMITLTFQLTSSLFQPVIGYITDKRSMPWS-----LPVGMCFTLC 102
Cdd:pfam13347 3 GSGALAAGIKYAGLATYLLYFYTDVLGLSAAAV--GLVLLVARLVDAFTDPIVGHIIDRTRTRWGrrrpwLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 103 GLILLA------LAGSFGMVLLAAALVGTGSSVFH-PESSRVARMA--SGGRHGLA--QSLFQVGGNFGSSLGPLLAAVI 171
Cdd:pfam13347 81 SFILLFtppelgRAPLFIWLLATYILLRIAYTFFEiPYWSLGPELTrdYDERTSLTsyRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 172 IAPYGKGNVAWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKPAIV--NPLPRKKVILAVG-----ILLMLIFS----KY 240
Cdd:pfam13347 161 LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGqkEAGSLLDMLKEVFrnrafLILLASFLlaalAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 241 FYMASISSYYTFYLMHKFGLtvqnAQLHLFAFLFAVAAGTVIGGPVGDKIGRK-YVIWGSILGVAPFTLV--LPYASLEW 317
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFA----ASAFPLVFTIGALLGIPLWPPLAKRIGKKnTYILGALITIAGFALAllLGPNNTLL 316
|
330
....*....|....*...
gi 490249292 318 TGILTVIIGFILASAFSA 335
Cdd:pfam13347 317 FLVLYIIIGFGYGSSFFL 334
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
41-345 |
4.74e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 41 QSLILAIYPLLQAEFSlTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAA 120
Cdd:cd17502 12 QTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 121 ALVGTGSSVFHPESSRV-ARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLA-ALLAIVVLSQIS 198
Cdd:cd17502 91 AIQGIGGGGLMSLAFIIiADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPiGGLALALLRTIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 199 rwyaaqhrmnkgkpkpaivnplprkkvilavgILLMLIFSKYFYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAA 278
Cdd:cd17502 171 --------------------------------LSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVI 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490249292 279 GTVIGGPVGDKIGR-KYVIWGS----ILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELLP 345
Cdd:cd17502 219 GSIISGALISKTGRyKPLIVIGtilmSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVP 290
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
81-207 |
5.51e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.79 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 81 GYITDK-----RSMPWslpvGMCFTLCGLILLALAG-SFGMVLLAAALVGTGSSVFHPE-SSRVARMASGGRHGL--AQS 151
Cdd:cd17346 61 GWLADKvlgarRTVFI----GGILMALGYLLLALSPfSVSMLYLGLALIIVGNGLFKPNiSSLVGKLYDENDPRRdsGFS 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 490249292 152 LFQVGGNFGSSLGPLLAAVIIAPYGKGNVawFVLAA---LLAIVVLSQISRWYAAQHRM 207
Cdd:cd17346 137 IFYMGINLGAFLAPLLCGTLGDNYGYHYG--FGLAAvgmLLGLLIFLLGRKKLLERKKM 193
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
103-348 |
5.54e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.80 E-value: 5.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 103 GLILLALAGSFGMVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVa 181
Cdd:cd17365 77 FTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAiTLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSV- 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 182 wFVLAALLAIVVLsqisrwyaaqhrmnkgkpkpaivnPLPRKKVILAVGILlMLIFSKYFYMAsissyYTFYLMHKFGLT 261
Cdd:cd17365 156 -FLLGGVPPLILL------------------------PLLRGTLLLWVTFF-MGLLLVYLLNS-----WLPKLMVEAGYS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 262 VQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYASLEWTGILTVI--IGFILASAFSAILVY 339
Cdd:cd17365 205 LSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVflAGACVNGAQVGLYAL 284
|
....*....
gi 490249292 340 AQELLPGRI 348
Cdd:cd17365 285 AARFYPTEV 293
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
62-333 |
5.63e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.82 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 62 IGMITLTFQLTSSLFQPVIGYITDK------RSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALV-----GTGSSVF 130
Cdd:cd17332 37 AGTIFLVARIIDAINDPLMGYLIDRtrsrwgRFRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALItyillDLLYTLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 131 H-PESSRVARMA--SGGRHGLaQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVA--WFVLAALLAIV-VLSQISRWYAAQ 204
Cdd:cd17332 117 NiPYTALIPELTddPEERTSL-TSWRMFFATIGGLLVTVLPPPLVAYFGGGNASrgYFLTALIIGIIgIILLLICFFGTR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 205 HRMNKGKPKPAIVNPLPRKKVILAVGILLMLIFSKYFYM---ASISSYYTFYLMHKFGLTvQNAQLHLFAFLFAVAAGTV 281
Cdd:cd17332 196 ERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFlafNIVNTVLVYYFKYVLGGR-AELVLLLLLILSGALLALL 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 490249292 282 IGGPVGDKIGRKYVIWGSILGVAPFTL---VLPYASLEWTGILTVIIGFILASAF 333
Cdd:cd17332 275 PWPPLKKRFGKKKAFFIGLLLAILGLLllfFLPPGNLVLILVLAVLAGIGYGGAN 329
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
29-110 |
7.19e-04 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 41.47 E-value: 7.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 29 AISLSHLLNDMIQSLiLAIYPLLQAEFSLTF--VQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLIL 106
Cdd:cd17491 3 AYGVGHVLNDLCASM-WFTYLLVYFHLVLGFssALAGILLLIGQVADAISTPLVGYESDRTNGCGKYGRRKSWHLIGTIC 81
|
....
gi 490249292 107 LALA 110
Cdd:cd17491 82 VLLS 85
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
48-399 |
8.11e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.09 E-value: 8.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 48 YPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGS 127
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 128 SV----FHPESSRVARmaSGGRHGLA--QSLFQVGGNFGSSLGPLLAAVIIAPYgkgnvAWFVLAALLAIVVLSQISRWY 201
Cdd:cd17393 102 GAldvaMNAQGVAVER--AYGRPIMSslHAMWSLGGLAGALLGAAAIGAGVSPG-----VHLLAAAVLLLLAALVAIRAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 202 AAQHRMNK--GKPKPAIVNPLPRKKVILAVGILlmlIFSKYFYMASISSYYTFYLMHKFGLTVQNAQLHLFAFLFAVAAG 279
Cdd:cd17393 175 LPGTGEAAedRPDGAGKPGFLLPNRLLLLLGLL---ALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 280 TVIGGPVGDKIGRKYVI-WGSILGVAPFTLVLPYASLEWTGILTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGF 358
Cdd:cd17393 252 RLFGDRLVDRFGDVAVLrAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490249292 359 AFGMGGLGAAVLGLLADHTSIDLVYkicAFLPLLGFLTIFL 399
Cdd:cd17393 332 GYLGFLVGPPLIGFLADATGLRTAF---LVVALLALLVALL 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
71-199 |
8.18e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 8.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 71 LTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLA 149
Cdd:cd17329 247 LLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTlVAALAPPDKRGSY 326
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 490249292 150 QSLFQVGGNFGSSLGPLLAAVIIAPYGkGNVAWFVLAALLAIVVLSQISR 199
Cdd:cd17329 327 MGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
77-199 |
1.08e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 77 QPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAG-SFGMVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQ 154
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPfPPLALLLFAALFGLGWGATVPLTAAlAARYFGARSYGTLFGLVF 341
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 490249292 155 VGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLSQISR 199
Cdd:cd17355 342 APHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
254-347 |
1.22e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.65 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 254 LMHKFGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYA-SLEWTGILTVIIGFILASA 332
Cdd:cd17365 25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAqSVLQLALLRFLTGLGLGAA 104
|
90
....*....|....*
gi 490249292 333 FSAILVYAQELLPGR 347
Cdd:cd17365 105 MPNAITLVSEYAPAR 119
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
39-336 |
1.65e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 39 MIQSLILAIYPLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITD---KRSMpwsLPVGMCFTLCGLILLALAGSFGM 115
Cdd:cd17504 10 LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDlygRKKV---LLIVLAIYTAGSLLAAFAPNLPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 116 VLLAAALVGTGSSVFhPESSRVARMA-SGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVL 194
Cdd:cd17504 87 LIAGRALQGIGGAVF-PLAFALVREEfPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 195 SQISRWYAAQHRMnkgkpkpaivnplprkkVILAVGILLMLIFSKYFYMASIssyyTFYLMHKFGLTVQNAQLHLFAFLF 274
Cdd:cd17504 166 VPLIDLRLLRRRN-----------------VLLANITALLAGFGMFMVFQLL----PQLLQLPTPTGFGLGITEAGLLLL 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490249292 275 AVAAGTVIGGPVGDKIGRKY-----VIWGSILGVAPFTLVLPY-ASLEWTGILTVIIGFILASAFSAI 336
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVgprrvLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASL 292
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
16-194 |
3.00e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.54 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 16 PPQKARTSFGILGAISLSHLLNDMIQSLILAIYPLL-QAEFSLTFVQIGMITLTFQLTSSLFQP-VIGYITDKRSMPWSL 93
Cdd:cd17388 197 GSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFtEDRFDWSPTMVGLSLAVFGLLHALFQAfVTGPIAKRLGEKRAI 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 94 PVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIA 173
Cdd:cd17388 277 LLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFA 356
|
170 180
....*....|....*....|...
gi 490249292 174 --PYGKGNVAWFVLAALLAIVVL 194
Cdd:cd17388 357 asPATWPGLAWIIGAALYLICLV 379
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-346 |
3.15e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 61 QIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAGSFGMVLLAAALVGTGSSVFHPES-SRVAR 139
Cdd:cd17477 32 LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 140 MASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIiapyGKGNVAWFVLAA---LLAIVVLSQISRWYAAQHRMNKGKPKpai 216
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLALV----GTAGALPFLIAAvllLLALVPLLLTRRAAPEIEEAESISLR--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 217 vnplprkKVILAVGILLMLIFSKYFYMASISSYYTFYLMHKfGLTVQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVI 296
Cdd:cd17477 185 -------RLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 490249292 297 WGSILGVAPFTLVLPYASLE--WTGILTVIIGFILASAFSAILVYAQELLPG 346
Cdd:cd17477 257 LGCALLGALAALLLPLVPGLplALLVLLFLWGGAAGPLYTLALALAGDRLPG 308
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-348 |
3.84e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 64 MITLTFqLTSSLFQPVIGYITDK---RSMPWSLPVGMCFTLcglILLALAGSFGMVLLAAALVGTGSSVFHPESSRVARM 140
Cdd:cd17391 41 AFSSTF-LVSAIFSPIWGRLADRygrKPMLLRASLGMAIVI---GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 141 ASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVaWFVLAALLAIVVLSQISRWYAAQHRMNKGKPKP--AIVN 218
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNV-FFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVStkEVWN 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 219 PLPRKKVILAVGILLMLIfskYFYMASISSYYTFYLMHkfgLTVQNAQLHLFAFLFAVAAG------TVIGGPVGDKIGR 292
Cdd:cd17391 196 SVPNPSLLISLFVTTFII---QLANQSIEPILTLYIRQ---LMGDASNLAFISGLVFSATGvssllsAPRLGKLGDRIGH 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 490249292 293 KYVIWGSILGVAPFTLVLPYASLEWT-GILTVIIGFILASAFSAILVYAQELLPGRI 348
Cdd:cd17391 270 HRILLGALLASALLYIPQAFVQTPWQlGILRFLLGLATGGLLPAINSLLAKITPKEV 326
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
39-195 |
5.53e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 5.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 39 MIQSLILAIYplLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMCFTLCGLILLALAG---SFGM 115
Cdd:cd17321 185 GGLLFLLPLY--LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadsSVWL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 116 VLLAAALVGTGSSVFHPESSRVARMASG-GRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVL 194
Cdd:cd17321 263 LLPGLVLLGLGLGLFATPLTNAALSSVPkEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAA 342
|
.
gi 490249292 195 S 195
Cdd:cd17321 343 A 343
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
272-347 |
5.74e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.33 E-value: 5.74e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490249292 272 FLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYA-SLEWTGILTVIIGFILASAFSAILVYAQELLPGR 347
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSpSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPK 110
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
49-193 |
6.66e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 38.49 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITD----KRSMPWSLPV-GMCFTLCGLILLALAGSFGMVLLAAALV 123
Cdd:PRK09556 53 NDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADgkntKQFLPFLLILsAICMLGFGASLGSGSVSLGLMIALWALS 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490249292 124 GTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLgpllaAVIIAPYG-----KGNVA-WFVLAALLAIVV 193
Cdd:PRK09556 133 GFFQSTGGPCSySTITRWTPRRKRGRFLGFWNISHNLGGAG-----AGGVALWGanyffDGHVIgMFIFPSIIALII 204
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
49-193 |
7.50e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.38 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490249292 49 PLLQAEFSLTFVQIGMITLTFQLTSSLFQPVIGYITDKRSMPWSLPVGMcfTLCGLILLALA------GSFGMVLLAAAL 122
Cdd:cd17345 27 PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGL--ILSAIINILIGfvpsatSSVGLMFILLFL 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490249292 123 VGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAVIIAPYGKGNVAW-FVLAALLAIVV 193
Cdd:cd17345 105 NGWFQGMGWPPSGRtMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGaFIFPAIIAIIV 177
|
|
| |
