|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
1-457 |
0e+00 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 709.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 1 MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGR 80
Cdd:PRK01766 4 TQKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 81 RERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPG 160
Cdd:PRK01766 84 RERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 161 MVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQ 240
Cdd:PRK01766 164 MVIGFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 241 LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVG 320
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 321 VGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGL 400
Cdd:PRK01766 324 VGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGL 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 490250554 401 PSGYLLALTDmivpRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR 457
Cdd:PRK01766 404 PLGYILALTD----PMGPFGFWIGLIIGLTAAAILLLLRLRKLQRQPSAIILQRAAR 456
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
7-445 |
3.92e-177 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 502.80 E-value: 3.92e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 7 EARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAP 86
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 87 QVRQGFWLAGFVSVLIMVVLWNAGYIISSMhNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLLWLAPPILPLM-GQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 167 GLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQLGLPIA 246
Cdd:cd13131 160 ALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 247 LALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLA 326
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 327 VFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLL 406
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399
|
410 420 430
....*....|....*....|....*....|....*....
gi 490250554 407 ALTDmivpRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQR 445
Cdd:cd13131 400 AFTT----GLGAFGVWIGLIIGLALAAILLLWRFRRLQR 434
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
17-362 |
3.21e-100 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 303.40 E-value: 3.21e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 17 PVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQGFWLAG 96
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 97 FVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNY 176
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 177 IFIYGHFGMpeLGGVGCGVATASVYWVMFASMLWWVRRARTMRdiRCAERFSGPDFAVLLRLVQLGLPIALALFFEVTLF 256
Cdd:TIGR00797 161 ILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAKKIG--LKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 257 AVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVFTAIFTVLM 336
Cdd:TIGR00797 237 ALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330 340
....*....|....*....|....*.
gi 490250554 337 RKQIALLYNDNPEVVTLASHLMLLAA 362
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
9-439 |
1.33e-93 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 289.35 E-value: 1.33e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVV-LWNAGYIISSMhNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIG 167
Cdd:COG0534 88 GQALLLALLLGLLLTLLgLLFAPPLLRLL-GADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 168 LLVNIPVNYIFIYGhfgmPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERfsGPDFAVLLRLVQLGLPIAL 247
Cdd:COG0534 167 NVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDL--RPDRKILKRILRIGLPAGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 248 ALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAV 327
Cdd:COG0534 241 QQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 328 FTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLA 407
Cdd:COG0534 321 LLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLA 400
|
410 420 430
....*....|....*....|....*....|..
gi 490250554 408 LTDmivprMGPAGFWCGFIIGLTSAAIMMMLR 439
Cdd:COG0534 401 FLG-----LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-441 |
3.75e-72 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 234.34 E-value: 3.75e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13133 85 WQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 169 LVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRaRTMRDIRCAERFSGPDFAVLLRLVQLGLPIALA 248
Cdd:cd13133 165 VVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFR-RKNRRRFGLRRAWRFDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 249 LFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVF 328
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 329 TAIFTVLMRKQIALLYNDNP---EVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYL 405
Cdd:cd13133 324 LGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYL 403
|
410 420 430
....*....|....*....|....*....|....*.
gi 490250554 406 LaltdmIVPRMGPAGFWCGFIIGLTSAAIMMMLRMR 441
Cdd:cd13133 404 L-----VVLGAGLAGAWTVETVYVIVLALIFLLRFR 434
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
5-446 |
9.72e-68 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 223.47 E-value: 9.72e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 5 FVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERI 84
Cdd:PRK00187 6 TTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 85 APQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNiDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMG 164
Cdd:PRK00187 86 TRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQ-APQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVIS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 165 FIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQLGLP 244
Cdd:PRK00187 165 LAGAVANLLLNYALIEGWFGLPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAALRELWRLGLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 245 IALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVG-V 323
Cdd:PRK00187 245 IGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGaV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 324 CLAVFTAIFTVLMRKQIALLYN----DNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLG 399
Cdd:PRK00187 325 VMLLFAGLFWLLPEAIIGLFLDrndpAFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVG 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 490250554 400 LPSGYLLALTdmivPRMGPAGFWCGFIIGLTSAAIMMML----RMRFLQRQ 446
Cdd:PRK00187 405 APLAWLLAFT----LGWGAVGVWWGLALGLACAAVALTLafewKTARLLRK 451
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
7-438 |
1.64e-60 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 203.57 E-value: 1.64e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 7 EARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIwlpAILFGHGLLL----ALTPVVAQLNGSGRRE 82
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSF---ANVTGFSILLglasALDTLCGQAFGAKNYK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 83 RIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHnIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMV 162
Cdd:cd13132 78 LVGVYLQRALVILLLCCVPISLLWLNTEPILLLLG-QDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 163 MGFIGLLVNIPVNYIFIYGHfgmpELGGVGCGVATASVYWVMFASMLWWVRRARTMRDirCAERFSGPDFAVLLRLVQLG 242
Cdd:cd13132 157 ISLVALLLNILLNYLLVFVL----GLGFIGAALATSISYWLIVVLLLLYIFFSKGHKA--TWGGFSREAFRGWGPFLKLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 243 LPIALALFFEVTLFAVVALLVSPL-GIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGV 321
Cdd:cd13132 231 IPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALIL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 322 GVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLP 401
Cdd:cd13132 311 SLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLP 390
|
410 420 430
....*....|....*....|....*....|....*..
gi 490250554 402 SGYLLALtdmiVPRMGPAGFWCGFIIGLTSAAIMMML 438
Cdd:cd13132 391 VGLLLAF----VLGLGLKGLWIGLIAGLILQAVILLL 423
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-441 |
8.76e-59 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 198.89 E-value: 8.76e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 169 LVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMrdIRCAERFSGPDFAVLLRLVQLGLPIALA 248
Cdd:cd13137 161 VLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLP--IKISFKGFRLDRKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 249 LFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVF 328
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 329 TAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLAl 408
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLG- 397
|
410 420 430
....*....|....*....|....*....|...
gi 490250554 409 tdmIVPRMGPAGFWCGFIIGLTSAAIMMMLRMR 441
Cdd:cd13137 398 ---FVLGLGLTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
15-439 |
7.79e-48 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 169.81 E-value: 7.79e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 15 AIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQGFWL 94
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 95 AGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPV 174
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 175 NYIFIYGhFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCaeRFSGPDFAVLLRLVQLGLPIALALFFEVT 254
Cdd:cd12082 161 DPLLIFG-LGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKL--SLLKPDLELLRRLLRIGLPSAIQNSLLSL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 255 LFAVVALLVSPL-GIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVFTAIFT 333
Cdd:cd12082 238 GLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 334 VLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLALTDmiv 413
Cdd:cd12082 318 LLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG--- 394
|
410 420
....*....|....*....|....*.
gi 490250554 414 prMGPAGFWCGFIIGLTSAAIMMMLR 439
Cdd:cd12082 395 --LGLYGIWLALVISLILAALVLLLF 418
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-441 |
2.67e-45 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 163.06 E-value: 2.67e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGapgyLFFQVARNQCEGL----AKTKPGMVMG 164
Cdd:cd13134 83 GVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGS----LFLQALSLTLSAIlrshGRTKIPMYVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 165 FIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATAsVYWVMFASMLWWVRRaRTMRDIRCAERFSGPDFAVLLRLVQLGLP 244
Cdd:cd13134 159 LIMNILNIVGNYLLIFGWFGLPKLGVAGVAISTV-ISRAVGLVLLFILLF-RKLKIRFRLKDLRPFPKKLLKKILKIGLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 245 IALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVC 324
Cdd:cd13134 237 SAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 325 LAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGY 404
Cdd:cd13134 317 VSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAY 396
|
410 420 430
....*....|....*....|....*....|....*..
gi 490250554 405 LLAltdmIVPRMGPAGFWCGFIIGLTSAAIMMMLRMR 441
Cdd:cd13134 397 LLG----IVLGLGLLGVWIAFAADEWVRGIIMLWRWR 429
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-446 |
1.36e-37 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 142.21 E-value: 1.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATD-MAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQ 87
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAaLAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 88 VRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAP---GYLFFQVARNqceGLAKTKPGMVMG 164
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPfifGYNAYSAILR---GLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 165 FIGLLVNIPVNYIFIYGhFGMpelGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRcaERFSGPDFAVLLRLVQLGLP 244
Cdd:cd13138 160 IIACVLNIILDLLFIAV-FHM---GVAGAALATVIAQAISVLLALYYLRKKKLPFKLS--LKDFRFDKEILKEILKIGLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 245 IALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVC 324
Cdd:cd13138 234 SALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 325 LAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGY 404
Cdd:cd13138 314 IGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAY 393
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 490250554 405 LLaltdMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQ 446
Cdd:cd13138 394 LL----SRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-438 |
8.15e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 134.63 E-value: 8.15e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 8 ARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQ 87
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 88 VRQGFWLAGFVSVLIMVV-LWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13142 90 AGQTFSFVIILSLILAVLgYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 167 GLLVNIPVNYIFIYGHFGMPELGGVGCGVATA---SVYWVMFASMLWWVRRA--RTMRDIRcaerfsgPDFAVLLRLVQL 241
Cdd:cd13142 170 SVLLNVILDPLLIFGIGPFPGLGVAGAALATVisrGIAAVIGLYLLFKGRVGlkISLRDLK-------PDWEWLKKIFRI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 242 GLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGV 321
Cdd:cd13142 243 GLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 322 GVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLP 401
Cdd:cd13142 323 IFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIP 402
|
410 420 430
....*....|....*....|....*....|....*..
gi 490250554 402 SGYLLALtdmiVPRMGPAGFWCGFIIGLTSAAIMMML 438
Cdd:cd13142 403 LAYLLAY----VLGLGVTGIWIAMAISNIVAALIALA 435
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
17-177 |
6.21e-32 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 119.59 E-value: 6.21e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 17 PVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQGFWLAG 96
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 97 FVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNY 176
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 490250554 177 I 177
Cdd:pfam01554 161 L 161
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
9-441 |
1.51e-31 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 125.37 E-value: 1.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGY-SATDMAAVAIGTSI-----WLPAIlfghgLLLALTPVVAQLNGSGRRE 82
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLgSAAYLGAVALGTTIfntlfWLFGF-----LRMGTTGLVAQALGAGDRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 83 RIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMV 162
Cdd:cd13136 78 EAIALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 163 MGFIGLLVNIPVNYIFIYGhFGMpelgGVGcGVATASVY--WVMFASMLWWVRraRTMRDIRCAERFSGPDFAVLLRLVQ 240
Cdd:cd13136 158 LQIVGNVVNIVLDPLFVFG-LGW----GVA-GAALATVIaqYLGALLGLWLLR--RRVRLLGKSLSRRLPSKAALKRLFK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 241 LGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVG 320
Cdd:cd13136 230 LNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 321 VGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRsiffitFTAYWVLGL 400
Cdd:cd13136 310 WGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTR------YLRNSMLVS 383
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 490250554 401 PSGYLLALTdMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMR 441
Cdd:cd13136 384 LAVFLPLLF-LLVPLWGNHGLWLALILFMLLRGLTLALRLP 423
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
244-405 |
3.72e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 111.89 E-value: 3.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 244 PIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGV 323
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 324 CLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYwVLGLPSG 403
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
..
gi 490250554 404 YL 405
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-441 |
3.05e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 110.07 E-value: 3.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 11 LLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQ 90
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 91 GFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLR--ALLWGAPGYLFFQVARNQceGLAKTKPGMVMGFIGL 168
Cdd:cd13135 83 SIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRifSIYLLLLGILFTFSSILQ--GIGETKPIMYGGIIKN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 169 LVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQLGLPIALA 248
Cdd:cd13135 161 LLNVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTIKLGLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 249 LFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVF 328
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 329 TAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFIT-FTAYWVLGlpsgylLA 407
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQiIGTIIVVS------VA 394
|
410 420 430
....*....|....*....|....*....|....
gi 490250554 408 LTDMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMR 441
Cdd:cd13135 395 LLLIFVFKLGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-431 |
1.96e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 104.91 E-value: 1.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 8 ARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAV-AIGTSIWLpailfghGLLLALTPV------VAQLNGSGR 80
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgTAGFFVWL-------AYALALLSKigaqvkVSQSIGAKD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 81 RERIAPQVRQGFWLAGFVSVLIMVVLWNAG-YIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKP 159
Cdd:cd13140 77 EKEARKYARNALQLNLLLGILYGLLLLLFAkPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 160 GMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARtmRDIRCAERFSGPDFAVLLRLV 239
Cdd:cd13140 157 PFIINAIGLVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKK--GLFLKIRILKRPDRKYIKEIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 240 QLGLPIAL--ALFfevTLFAVV-ALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSAR 316
Cdd:cd13140 235 KLGLPVALqsILF---ALISMIlARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 317 TGVGVGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTR--SIFFITFTA 394
Cdd:cd13140 312 TALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKppAIISIVFNG 391
|
410 420 430
....*....|....*....|....*....|....*..
gi 490250554 395 ywvLGLPSGYLLaltdmIVPRMGPAGFWcgFIIGLTS 431
Cdd:cd13140 392 ---LRIPLALLL-----SPTGLGLNGIW--WAISISS 418
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-445 |
3.80e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 95.36 E-value: 3.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 14 LAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQGFW 93
Cdd:cd13145 14 LAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 94 LAGFVSVLIMVV-LWNAGYIISSMHNIDPLLAEkAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNI 172
Cdd:cd13145 94 FGIILAILLTVIgLFAAPPLFRLLGAEGDYLDL-ALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 173 PVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCaeRFSGPDFAVLLRLVQLGLPIALALFFE 252
Cdd:cd13145 173 ILDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRL--RDFIPRLDVYKEILKQGFPASLNMMTI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 253 VTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVFTAIF 332
Cdd:cd13145 251 GLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 333 TVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLALtdmi 412
Cdd:cd13145 331 LLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVN---- 406
|
410 420 430
....*....|....*....|....*....|....
gi 490250554 413 VPRMGPAGFWCG-FIIGLTSAAIMMMLRMRFLQR 445
Cdd:cd13145 407 VLGLGVTGIWWGiFTIVWSAAIIALLYTRRVLKK 440
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-401 |
8.45e-20 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 91.03 E-value: 8.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAvAIGTSIWLPAILFGHGLLLAL--TPVVAQLNGSGRRERIAP 86
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALA-AVNLVFPIIMLLMALGLMIGVggASLISRRLGAGDREKANR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 87 QVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQ--CEGLAKTkpGMVMG 164
Cdd:cd13143 83 IFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLlrAEGKPKL--AMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 165 FIGLLVNIPVNYIFIYGhFGMpelGGVGCGVATASVYWVMFASMLWWVRRARTMrdIRCAERFSGPDFAVLLRLVQLGLP 244
Cdd:cd13143 161 LIGAVLNIILDPLFIFV-LGL---GIAGAALATVIAQLISLLLLLLYFFRGKSL--LKLSLLRFKLSLKIIKEILALGFP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 245 IALA-LFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGV 323
Cdd:cd13143 235 SFLMqLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVAL 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490250554 324 CLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLP 401
Cdd:cd13143 315 IYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIP 392
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
9-449 |
3.42e-19 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 89.79 E-value: 3.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:PRK10189 29 REITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAG-YIISSMHN-IDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:PRK10189 109 RQSLVIMTLFAVLLAVLIHFFGeQIIDLVAGdATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 167 GLLVNIPVNYIFIYGHFGMPELGGVGCGVA-TASVYWVMFASMLWWVRRARTMRDIRCAERFSGPDFAVLLRLVQLGLPI 245
Cdd:PRK10189 189 MNILNIIISSILIYGLFSWQGLGFVGAGLGlTISRYIGAVAIIWVLMIGFNPALRISLKSYFKPLNFAIIWEVMGIGIPA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 246 ALalffEVTLFAVVALL----VSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGV 321
Cdd:PRK10189 269 SI----ESVLFNGGKLLtqmfVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRHVFWL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 322 GVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLL-AAIYQISDSIQVIGSGiLRGYKDTRSIFFITFTAYWVLGL 400
Cdd:PRK10189 345 STLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLnALFMPIWAASWVLPAG-LKGARDARYAMWVSMLGMWGCRV 423
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 490250554 401 PSGYLLAltdmIVPRMGPAGFWCGFIIGLTSAAIMMMLRM---RFLQRQPSS 449
Cdd:PRK10189 424 VAGYILG----IMLGFGVVGVWMGMFLDWAVRGVLFYWRMvsgRWLWKYPRP 471
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-434 |
7.27e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 76.50 E-value: 7.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13139 94 VQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLAN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 169 LVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMrdIRCAERFSGPDFAVLLRLVQLGLPIALA 248
Cdd:cd13139 174 GLNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGR--IQIRRRHLKLDWAIIKKIIKIAVGGILQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 249 LFFEVTLFAVVALLVSPLGIIDVAGHQIALNFssLMFVLPLS--LAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLA 326
Cdd:cd13139 252 FLIASSSWIFLVRIIAEFGSTALAGYTIAIRI--IMFALLPAwgLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 327 VFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLL 406
Cdd:cd13139 330 GIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLL 409
|
410 420
....*....|....*....|....*...
gi 490250554 407 AltdmIVPRMGPAGFWCGFIIGLTSAAI 434
Cdd:cd13139 410 A----RHLNLGPKGVFIAIPIAETVLAI 433
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-443 |
4.29e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 73.81 E-value: 4.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGyLFFQVARN---QCEGlaKTKPGMVMGF 165
Cdd:cd13144 88 NNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFG-MFFQILCEkvlQSTG--NTITPMIAQL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 166 IGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCaeRFSGPDFAVLLRLVQLGLPI 245
Cdd:cd13144 165 IGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDL--RLFRPSLRIIKEIYAVGLPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 246 ALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQG------STIDAQVSARTGV 319
Cdd:cd13144 243 IIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGnkdrirEAIKYAILIAVVI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 320 GVGVCLAVFtaiftvLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLG 399
Cdd:cd13144 323 MLAGGLLFQ------LFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVL 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 490250554 400 LPSGYLLALTdmivprMGPAGFWCGFIIGLTSAAIMMMLRMRFL 443
Cdd:cd13144 397 LPLAWLLAKM------FGLNGVWWSFPIAEIVSFLLSLLFLKRL 434
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-326 |
3.84e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 70.76 E-value: 3.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 11 LLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIW-LPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVR 89
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLmLTQMMSNGAMGGGVSSAIARALGAGDRERAEALVW 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 90 QGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLL 169
Cdd:cd13148 94 HALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 170 VNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRART-MRDIRCAERFSGPDFAVLLRlvqLGLPIALA 248
Cdd:cd13148 174 VQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSrLRLRLRALRLERRLFRDILR---VGLLAALS 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490250554 249 LFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLA 326
Cdd:cd13148 251 PLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVLA 328
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-405 |
3.86e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 70.80 E-value: 3.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 8 ARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQ 87
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 88 VRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTK-PGMVMGFI 166
Cdd:cd13149 88 ATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKrPSLVMLGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 167 GLlVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVrrARTMRDIRCAERFSGPDFAVLLRLVQLGLPIA 246
Cdd:cd13149 168 AL-VNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFL--HYHHRLIDFSEPSLKALFRSWKDILSIGIPAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 247 LALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQ----VSARTGVGVG 322
Cdd:cd13149 245 LSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQeglkISLKFSLIYG 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 323 VCLAVFTAIFTvlmrKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPS 402
Cdd:cd13149 325 AILGIVLALFA----GWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPL 400
|
...
gi 490250554 403 GYL 405
Cdd:cd13149 401 AYV 403
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
7-200 |
1.08e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 66.33 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 7 EARQLLALAIPVILAQVAqTAMGFVD-TVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIA 85
Cdd:cd13138 223 ILKEILKIGLPSALQQSL-VSISFLIiNSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAK 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 86 PQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGF 165
Cdd:cd13138 302 KGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISI 381
|
170 180 190
....*....|....*....|....*....|....*.
gi 490250554 166 IGL-LVNIPVnyIFIYGHFGMPELGGVGCGVATASV 200
Cdd:cd13138 382 LRLwLVRIPL--AYLLSRLTGLGLFGIWLAMPISNI 415
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
8-210 |
3.00e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 64.84 E-value: 3.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 8 ARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQ 87
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRY 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 88 VRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIG 167
Cdd:cd13137 305 GKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLIS 384
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 490250554 168 L-LVNIPVNYIFIYgHFGMPELGgvgcgvatasVYWVMFASMLW 210
Cdd:cd13137 385 MwLVRLPLAYLLGF-VLGLGLTG----------IWLAMFVDTIV 417
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
11-446 |
4.54e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 64.49 E-value: 4.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 11 LLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQ 90
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 91 GFWLAGFVSVLIMVVLwnagyiissMHNIDPLL--------AEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMV 162
Cdd:cd13147 91 SILLGLIISIILTIVL---------LPFLEPILvlmgagevLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 163 MGFIGLLVNIPVNYIFIYGhFGMpelgGVGcGVATASVYWVMFASML---WWVRRARTMRDIRcaERFSGPDFAVLLRLV 239
Cdd:cd13147 162 AMVAGSILNIILDPIFIYT-LGL----GIA-GAAWATVISMLISSLVllyWFFVKKDTYVSLS--LKNFKFDKKIVKDIL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 240 QLGLPIALALF-FEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTG 318
Cdd:cd13147 234 KVGIPASLEQLiMSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 319 VGVGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHL---MLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAY 395
Cdd:cd13147 314 IKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIvafLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRE 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 490250554 396 WVLGLPSGYLLAltdmIVPRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQ 446
Cdd:cd13147 394 LIFQVLFAYLFA----IVLGLGLFGVWWGIVLGNAIGSIVGYLWARLYIKR 440
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
9-214 |
3.25e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 55.54 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIW-LPAILFGHGLLLALTPVVAQLNGSGRRERIAPQ 87
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYqLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 88 VRQGFWLAGFVSVLIMVVLW-NAGYIISSMH---NIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVM 163
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIvLAEPIVRLLFergAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRI 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 490250554 164 GFIGLLVNIPVNYIFiyghfgMPELGGVGCGVATASVYWVMFASMLWWVRR 214
Cdd:COG0728 382 AVIAVVVNIVLNLLL------VPPLGHAGLALATSLSALVNALLLLVLLRR 426
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
8-264 |
9.49e-08 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 54.40 E-value: 9.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 8 ARQLLALAIPVILAQVAQTAMGFVDTV------MAGGYSAtDMAAVAIG-------TSIWLPAIlFGHGLLLALTPVVAQ 74
Cdd:COG5841 232 LKELLRIAIPITLSSLVLPLFQLIDSFtvprrlQAAGLSA-SEATSLYGilsgmaqPLVNLPTV-LATALATSLVPAISE 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 75 LNGSGRRERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSM--HNidpllaEKAVGYLRALLWGAPGYLFFQVARNQCE 152
Cdd:COG5841 310 AFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLlfGN------PEGGGILAILAPSAIFLSLQQVTTGILQ 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 153 GLAKTKPGMVMGFIGLLVNIPVNYIFIyghfgmPELGGVGCGVATASVYWVMFASMLWWVRRaRTMRDIRCAERFSGPDF 232
Cdd:COG5841 384 GLGKQKIPVINLLIGLLVKIILNYLLV------PLFGIYGAALATVIGYLVAAILNLAALKK-YTGFKLDLRRRLLKPLL 456
|
250 260 270
....*....|....*....|....*....|....
gi 490250554 233 AVLLR--LVQLGLPIALALFFEVTLFAVVALLVS 264
Cdd:COG5841 457 ASLIMgiVVLLLYRLLSLFLPESRLGALLATLIA 490
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
9-214 |
1.25e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 53.63 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTV------MAGGYSaTDMAAVAIG-------TSIWLPAIlFGHGLLLALTPVVAQL 75
Cdd:cd13124 224 KELLSYAIPITLSSLILPLLQLIDSFtvprrlQAAGLS-ESEATALYGiltgraqPLVQLPTV-IATALSTSLVPAISEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 76 NGSGRRERIAPQVRQGF---WLAGFVSVLIMVVLwnAGYIISSMHNIDPllaekAVGYLRALLWGAPGYLFFQVARNQCE 152
Cdd:cd13124 302 YAKGDKKELRRRINQALrltLLIGLPAAVGLAVL--AEPINTLLFGDSE-----GGLILQILAPSILFLSLQQVTAAILQ 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490250554 153 GLAKTKPGMVMGFIGLLVNIPVNYIFIYGhfgmpeLGGVGCGVATASVYWVMFASMLWWVRR 214
Cdd:cd13124 375 GLGKVKIPVINLLIGLLVKIVLNYVLIPI------FGIYGAAIATVIGFLVAALLNLRALKK 430
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
11-209 |
9.10e-07 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 50.72 E-value: 9.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 11 LLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAV-AIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVR 89
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 90 QGFWLAGFVSVLIMVVLWNAGYIIssmhnIDPLLAEK---AVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPL-----LSLLFGPEyaeAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLI 329
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 490250554 167 GLLVNIPVNYIFIyghfgmPELGGVGCGVATASVYWVMFASML 209
Cdd:COG2244 330 GAVLNLVLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-438 |
9.32e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 50.86 E-value: 9.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 11 LLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAiGTSIWLPAIL----FGHGLLLALTPVVAQLNGSGRRERIAP 86
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVG-GIGLVFPLGMiflaLGNGIQVGVSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 87 QVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13146 89 AADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 167 GLLVNIPVNYIFIYGhFGMpelGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCaeRFSGPDFAVLLRLVQLGLPIA 246
Cdd:cd13146 169 GTVVNIVLDPILIFV-FDM---GVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHI--KLSNISSSVIVEILRVGLPQM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 247 LALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLA 326
Cdd:cd13146 243 LLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 327 VFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLL 406
Cdd:cd13146 323 LVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLL 402
|
410 420 430
....*....|....*....|....*....|..
gi 490250554 407 AltdmIVPRMGPAGFWCGFIIGLTSAAIMMML 438
Cdd:cd13146 403 A----YVFGKGITGVYFGIVSANFFTALLAMF 430
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
9-214 |
2.22e-06 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 49.76 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIW-LPAILFGHGLLLALTPVVAQLNGSGRRERIAPQ 87
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYqLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRT 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 88 VRQGFWLAGFVSVLIMVVLWNAGYIISSMH----NIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVM 163
Cdd:cd13123 295 LSRGLRLVLFLLLPAAVGLIVLAEPIVRLLfergAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKI 374
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 490250554 164 GFIGLLVNIPVNYIFiyghfgMPELGGVGCGVATASVYWVMFASMLWWVRR 214
Cdd:cd13123 375 AVIAVAVNILLNLLL------IKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-411 |
3.26e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 49.24 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQlnGSGRRERIAPQV 88
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSH--AVGRKDQGEANA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 89 --RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13141 89 vfNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 167 GLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCAErfSGPDFAVLLRLVQLGLPIA 246
Cdd:cd13141 169 AVLLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLAL--WRPDLPTWKRLLKIGLPSG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 247 LALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLA 326
Cdd:cd13141 247 GEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 327 VFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLL 406
Cdd:cd13141 327 LVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALPVIWLS 406
|
....*
gi 490250554 407 ALTDM 411
Cdd:cd13141 407 AQPDF 411
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
9-135 |
6.73e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 48.01 E-value: 6.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 9 RQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQV 88
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVA 295
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 490250554 89 RQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALL 135
Cdd:TIGR00797 296 RVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
8-213 |
1.81e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 46.77 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 8 ARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDM-----AAVAIGTSIWLPAILFGhgllLALTPVVAQLNGSgRRE 82
Cdd:cd13128 205 AKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAvgiynAAYRIAELLLFIPSAIS----TALFPRISELYKN-DKD 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 83 RIAPQVRQGFWLAGFVSVLIMVVLWN-AGYIISSMHNIDPLlaeKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGM 161
Cdd:cd13128 280 ELKKLLKKSFKYLFLISLPIAIGLFLfAEPIITLLFGEEYL---PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTL 356
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 490250554 162 VMGFIGLLVNIPVNYIFIyghfgmPELGGVGCGVATASVYWVMFASMLWWVR 213
Cdd:cd13128 357 KILLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-185 |
2.00e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 46.91 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 5 FVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERI 84
Cdd:cd13149 230 FRSWKDILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERV 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 85 ApQVRQGFWLAGFVSVLIM-VVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVM 163
Cdd:cd13149 310 Q-EGLKISLKFSLIYGAILgIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGL 388
|
170 180
....*....|....*....|....*
gi 490250554 164 GFIG-LLVNIPVNYI--FIYGHFGM 185
Cdd:cd13149 389 NLIRvFLLYIPLAYVgsHLLGFAGV 413
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
234-385 |
1.19e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 41.06 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490250554 234 VLLRLVQLGLPIALALFFEvTLFAVV-ALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQ 312
Cdd:cd13144 6 VLRLLLTMSIPAMISMLFQ-ALYNIVdSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEAN 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490250554 313 VSARTGVGVGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTR 385
Cdd:cd13144 85 KAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTI 157
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