|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
1-478 |
0e+00 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 820.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 1 MNVTSAVRQAVERTSWFKKRQRYRVLYWREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSF 80
Cdd:PRK10189 1 LNISSALRQVVHGTRWYAKRKSYRVLFWREITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDATAQVKDLALTYLELTALSY 160
Cdd:PRK10189 81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAGDATPEVKALALTYLELTVWSY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 161 PAAAIALIGSGALRGAGTTKIPLLINGGMNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNP 240
Cdd:PRK10189 161 PAAAITLIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 241 ALRLSLKGYFKPFNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTI 320
Cdd:PRK10189 241 ALRISLKSYFKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 321 ITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCA 400
Cdd:PRK10189 321 ITGTRLGKGQIAQAERQLRHVFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAG 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490253468 401 FKGARDVRYTMWVSMLGMWGCRVVAGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRWLWKYPRVKASSEES 478
Cdd:PRK10189 401 LKGARDARYAMWVSMLGMWGCRVVAGYILGIMLGFGVVGVWMGMFLDWAVRGVLFYWRMVSGRWLWKYPRPEPQKCEK 478
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-465 |
1.18e-106 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 323.69 E-value: 1.18e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 29 REISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 109 RQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDAtaQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGG 188
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADP--EVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 189 MNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNPalrLSLKGYFKPFNFAIIWEVMGIGIPA 268
Cdd:cd13137 159 VNVLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLP---IKISFKGFRLDRKIIKKLLRIGLPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 269 SIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTII 348
Cdd:cd13137 236 GLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 349 LTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYT 428
Cdd:cd13137 316 MGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395
|
410 420 430
....*....|....*....|....*....|....*..
gi 490253468 429 LGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRWL 465
Cdd:cd13137 396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-465 |
1.49e-82 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 262.05 E-value: 1.49e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLA 113
Cdd:cd13134 8 LAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 114 IMTLFSILLAGVIHAFGQEIIDFvaGDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILN 193
Cdd:cd13134 88 FNLLLGLVFSLLLLFFGAELLRL--MGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 194 ILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNPALRLSlkgYFKPFNFAIIWEVMGIGIPASIESV 273
Cdd:cd13134 166 IVGNYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLK---DLRPFPKKLLKKILKIGLPSAGEEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 274 LFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIA 353
Cdd:cd13134 243 SYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 354 WGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYTLGIVL 433
Cdd:cd13134 323 LLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIVL 402
|
410 420 430
....*....|....*....|....*....|..
gi 490253468 434 GMGVIGVWLGMVLDWAVRGVLFYFRMVSGRWL 465
Cdd:cd13134 403 GLGLLGVWIAFAADEWVRGIIMLWRWRSGKWI 434
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
28-458 |
3.73e-80 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 255.45 E-value: 3.73e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 28 WREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 108 ARQSLAIMTLFSILLAGVIHAFGQEIIDFVagDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLING 187
Cdd:COG0534 87 LGQALLLALLLGLLLTLLGLLFAPPLLRLL--GADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 188 GMNILNILISSVLIYGifswPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNPaLRLSLKGYfkPFNFAIIWEVMGIGIP 267
Cdd:COG0534 165 IGNVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSL-LRLRLRDL--RPDRKILKRILRIGLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 268 ASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTI 347
Cdd:COG0534 238 AGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 348 ILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGY 427
Cdd:COG0534 318 IGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
|
410 420 430
....*....|....*....|....*....|.
gi 490253468 428 TLGIvLGMGVIGVWLGMVLDWAVRGVLFYFR 458
Cdd:COG0534 398 LLAF-LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
28-464 |
2.47e-53 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 184.97 E-value: 2.47e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 28 WREISPLAVPILLENACVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGqFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 107 AARQSLAIMTLFSILLAGVIHAFGQEIIDFVagDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLIN 186
Cdd:cd13138 82 AVGTLLVLFLILGIVLTILGLLFAPPILRLM--NTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 187 GGMNILNILISSVLIYGifswPGLGFVGAGLGLTIARYIGAIATIWVLMVGlNPALRLSLKgYFKpFNFAIIWEVMGIGI 266
Cdd:cd13138 160 IIACVLNIILDLLFIAV----FHMGVAGAALATVIAQAISVLLALYYLRKK-KLPFKLSLK-DFR-FDKEILKEILKIGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 267 PASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLST 346
Cdd:cd13138 233 PSALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 347 IILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAG 426
Cdd:cd13138 313 IIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLA 392
|
410 420 430
....*....|....*....|....*....|....*...
gi 490253468 427 YTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRW 464
Cdd:cd13138 393 YLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-464 |
2.64e-52 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 182.73 E-value: 2.64e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 28 WREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 108 ARQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDatAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLING 187
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHS--PEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 188 GMNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNPALRLSLKGYFkpFNFAIIWEVMGIGIP 267
Cdd:cd13133 162 VMVVVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWR--FDRELLRRILRLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 268 ASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTI 347
Cdd:cd13133 240 SGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 348 ILTLIAWGSAPFAGFIASFYTHEED---VKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCrVV 424
Cdd:cd13133 320 YMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLY-LL 398
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 490253468 425 AGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRW 464
Cdd:cd13133 399 PPAYLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-465 |
1.16e-50 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 178.15 E-value: 1.16e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLA 113
Cdd:cd13142 16 LAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 114 IMTLFSILLAGVIHAFGQEIIDFVAGdATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILN 193
Cdd:cd13142 96 FVIILSLILAVLGYILSRPLLLLLIG-APEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSVLLN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 194 ILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGlNPALRLSLKGyFKPfNFAIIWEVMGIGIPASIESV 273
Cdd:cd13142 175 VILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKG-RVGLKISLRD-LKP-DWEWLKKIFRIGLPSSIEQS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 274 LFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIA 353
Cdd:cd13142 252 ARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 354 WGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYTLGIVL 433
Cdd:cd13142 332 VLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVL 411
|
410 420 430
....*....|....*....|....*....|..
gi 490253468 434 GMGVIGVWLGMVLDWAVRGVLFYFRMVSGRWL 465
Cdd:cd13142 412 GLGVTGIWIAMAISNIVAALIALAWFKRGTWK 443
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
27-460 |
1.91e-45 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 164.21 E-value: 1.91e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 27 YWREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 107 AARQSLAIMTLFSILLAGVI-------HAFGQEiidfvagdatAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTT 179
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLLwlappilPLMGQE----------PEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 180 KIPLLINGGMNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMvgLNPALR-LSLKGYFKPFNFAII 258
Cdd:cd13131 151 RPAMVITLLALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIR--RHKRFRrYRLFARFWRPDWARL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 259 WEVMGIGIPASI----ESVLFNGGKLLtqmfVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQA 334
Cdd:cd13131 229 KELLRLGLPIGLtiffEVSLFAAVALL----MGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 335 EFQAWHVFWLSTIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVS 414
Cdd:cd13131 305 RRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLA 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 490253468 415 MLGMWGCRVVAGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMV 460
Cdd:cd13131 385 LISYWGIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFR 430
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
37-383 |
1.66e-43 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 156.64 E-value: 1.66e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 37 PILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAIMT 116
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 117 LFSILLAGVIHAFGQEIIDFVAGDatAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILNILI 196
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGAD--GEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 197 SSVLIYGIFSWpgLGFVGAGLGLTIARYIGAIATIWVLMVGlnPALRLSLKGYFKPfNFAIIWEVMGIGIPASIESVLFN 276
Cdd:TIGR00797 159 NYILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKA--KKIGLKWEGLLKP-DWEVLKRLLKLGLPIAFRVILES 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 277 GGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIAWGS 356
Cdd:TIGR00797 234 LSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIIL 313
|
330 340
....*....|....*....|....*..
gi 490253468 357 APFAGFIASFYTHEEDVKEVVKQLLWL 383
Cdd:TIGR00797 314 ILFREFIARLFTNDPEVLELAAIYLIF 340
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-464 |
1.72e-39 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 148.14 E-value: 1.72e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 29 REISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 109 RQSLAIMTLFSILLAGVIHAFGQEIIDFVAgdATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGG 188
Cdd:cd13139 94 VQAILLGVALSLILSILGYFFAEDILSLMG--ASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 189 MNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGlNPALRLSLKgYFKPfNFAIIWEVMGIGIPA 268
Cdd:cd13139 172 ANGLNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKG-KGRIQIRRR-HLKL-DWAIIKKIIKIAVGG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 269 SIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTII 348
Cdd:cd13139 249 ILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 349 LTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYT 428
Cdd:cd13139 329 LGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYL 408
|
410 420 430
....*....|....*....|....*....|....*.
gi 490253468 429 LGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRW 464
Cdd:cd13139 409 LARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
35-455 |
5.59e-36 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 137.84 E-value: 5.59e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 35 AVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAI 114
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 115 MTLFSILLAGVIHAFGQEIIDFvaGDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILNI 194
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSL--LGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 195 LISSVLIYGIFSwPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNpalRLSLKGYFKPFNFAIIWEVMGIGIPASIESVL 274
Cdd:cd12082 159 LLDPLLIFGLGP-PELGIAGAALATVISYVIGALLLLIYLRKGKK---ILKFKLSLLKPDLELLRRLLRIGLPSAIQNSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 275 FNGGKLLTQMFVAG-MGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIA 353
Cdd:cd12082 235 LSLGLLIIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 354 WGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYTLGiVL 433
Cdd:cd12082 315 LLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLA-YL 393
|
410 420
....*....|....*....|..
gi 490253468 434 GMGVIGVWLGMVLDWAVRGVLF 455
Cdd:cd12082 394 GLGLYGIWLALVISLILAALVL 415
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
28-461 |
2.66e-32 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 127.68 E-value: 2.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 28 WREISPLAVPILLENACVLLMGVLSTFLVSWLGKEA-MAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:cd13136 2 HREILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 107 AARQSLAIMTLFSILLAgvihAFGQEIIDFVAG--DATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLL 184
Cdd:cd13136 82 LLVRALLLALAIGLLLI----LLQSPLLALALLllGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 185 INGGMNILNILISSVLIYGIfswpGLGFVGAGLGLTIARYIGAIATIWVLMVGLNpalRLSLKGYFKPFNFAIIWEVMGI 264
Cdd:cd13136 158 LQIVGNVVNIVLDPLFVFGL----GWGVAGAALATVIAQYLGALLGLWLLRRRVR---LLGKSLSRRLPSKAALKRLFKL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 265 GIPASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVF-- 342
Cdd:cd13136 231 NRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLqw 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 343 -WLSTIILTLIAWGsapFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGmwgc 421
Cdd:cd13136 311 gLGLGVLLALLFFL---GGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS---- 383
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 490253468 422 rvVAGYTLGIVL---GMGVIGVWLGMVLDWAVRGVLFYFRMVS 461
Cdd:cd13136 384 --LAVFLPLLFLlvpLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-458 |
9.10e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 114.70 E-value: 9.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 29 REISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 109 RQSLAIMTLFSILLAgVIHAFGQEIIdFVAGDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGG 188
Cdd:cd13135 81 ISSIVYNSIIGVILF-LLWLFGARII-FVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 189 MNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLM----VGLNPALRLSLKGYFKPFNFAIiwevmGI 264
Cdd:cd13135 159 KNLLNVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRkikkLTFKLSNTKVLKANIRPYKFTI-----KL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 265 GIPASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWL 344
Cdd:cd13135 234 GLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 345 STIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYtMWVSMLGMWGCRVV 424
Cdd:cd13135 314 GLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKW-MLYTQIIGTIIVVS 392
|
410 420 430
....*....|....*....|....*....|....
gi 490253468 425 AGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFR 458
Cdd:cd13135 393 VALLLIFVFKLGLAGVYITLFIDEIIRAIINFLK 426
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
28-469 |
2.21e-27 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 114.14 E-value: 2.21e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 28 WREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:PRK01766 11 ARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 108 ARQSLAIMTLFSILLAGVIHAFGQEIIDFVagDATAQVKDLALTYLelTALSYpaAAIALIGSGALR----GAGTTKIPL 183
Cdd:PRK01766 91 VRQGLWLALFLSVLIMLVLYNAVPPILNMM--NLEPEVADIAVGYL--HALLW--GIPAYLLYQVLRsfidGLGKTKPTM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 184 LINGGMNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNPAlRLSLKGYFKPFNFAIIWEVMG 263
Cdd:PRK01766 165 VIGFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFR-DFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 264 IGIPASIeSVLFNGGKL-LTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVF 342
Cdd:PRK01766 244 LGLPIGL-AIFFEVSLFaVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 343 WLSTIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFmpiwSLSWTLPC----AFKGARDVRYTMWVSMLGM 418
Cdd:PRK01766 323 AVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALF----QFSDAIQVigsgALRGYKDTRVIFFITFIAY 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 490253468 419 WGCRVVAGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMvsgRWLWKYP 469
Cdd:PRK01766 399 WVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRL---RKLQRQP 446
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
34-446 |
5.37e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 112.64 E-value: 5.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLA 113
Cdd:cd13147 14 LSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 114 IMTLFSILLAGVIHAFGQEIIDFV-AGDataqVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNIL 192
Cdd:cd13147 94 LGLIISIILTIVLLPFLEPILVLMgAGE----VLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 193 NILISSVLIYGIfswpGLGFVGAGLGLTIARYIGAIATIWVLMVGLNPALRLSLKgYFKpFNFAIIWEVMGIGIPASIE- 271
Cdd:cd13147 170 NIILDPIFIYTL----GLGIAGAAWATVISMLISSLVLLYWFFVKKDTYVSLSLK-NFK-FDKKIVKDILKVGIPASLEq 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 272 ---SVLFnggKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTII 348
Cdd:cd13147 244 limSVLM---IILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLII 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 349 LTLIAWGSAPFAGFIASFYTHEEDVKEVVKQL---LWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVA 425
Cdd:cd13147 321 ELIIAILIFIFAPQIAYLFTYSEESAHLAPEIvafLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLF 400
|
410 420
....*....|....*....|.
gi 490253468 426 GYTLGIVLGMGVIGVWLGMVL 446
Cdd:cd13147 401 AYLFAIVLGLGLFGVWWGIVL 421
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
53-468 |
3.51e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 110.31 E-value: 3.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 53 TFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAIMTLFSILLAGVIHAFGQE 132
Cdd:cd13140 29 MFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLLLFAKP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 133 IIDFVAGDAtAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILNILISSVLIYGIFSWPGLGF 212
Cdd:cd13140 109 LIGFFNLGD-AEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIFGFGPFPALGV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 213 VGAGLGLTIARYIGAIATIWVLMVGLnpaLRLSLKGYFKPFNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTN 292
Cdd:cd13140 188 AGAALATVLAQAIVFLLFLYALKKKK---GLFLKIRILKRPDRKYIKEILKLGLPVALQSILFALISMILARIIASFGPV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 293 VIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIAWGSAPFAGFIASFYTHEED 372
Cdd:cd13140 265 AIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPE 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 373 VKEV-VKQLLWLNA--LFMpiwSLSWTLPCAFKGARDVRYTMWVSMLGMwGCRVVAGYTLGIvLGMGVIGVWLGMVLDWA 449
Cdd:cd13140 345 TIAIgVDYLRILGFsqLFM---CLEITTTGAFNGLGRTKPPAIISIVFN-GLRIPLALLLSP-TGLGLNGIWWAISISSI 419
|
410
....*....|....*....
gi 490253468 450 VRGVLFYFrmvsgrWLWKY 468
Cdd:cd13140 420 LKGIILTI------WFLLY 432
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-386 |
4.98e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 103.92 E-value: 4.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 28 WREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 108 ARQSLAIMTLFSILLAGVIHAFGQEIidFVAGDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLING 187
Cdd:cd13149 88 ATDSLILSLLLSVIVSLLGLFTIPPL--FSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVML 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 188 GMNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVglnpALRLSLKGYFKPFNFAIIW-EVMGIGI 266
Cdd:cd13149 166 GAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFLHY----HHRLIDFSEPSLKALFRSWkDILSIGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 267 PASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEfQAWHVFWLST 346
Cdd:cd13149 242 PAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQ-EGLKISLKFS 320
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490253468 347 IILTLIAW-GSAPFAGFIASFYTHEEDVKEVVKQLLWLNAL 386
Cdd:cd13149 321 LIYGAILGiVLALFAGWLASLFSAEPEVIELITLYLLIVPI 361
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
37-197 |
1.19e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 94.17 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 37 PILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAIMT 116
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 117 LFSILLAGVIHAFGQEIIDFVAGDATaqVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILNILI 196
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEE--VLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPL 158
|
.
gi 490253468 197 S 197
Cdd:pfam01554 159 N 159
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
50-446 |
2.02e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 93.43 E-value: 2.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 50 VLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAIMTLFSILLAGVIHAF 129
Cdd:cd13145 30 VVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 130 GQEIIDFVAGDATAQvkDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILNILISSVLIYGIFSWPG 209
Cdd:cd13145 110 APPLFRLLGAEGDYL--DLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFGGGGIPA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 210 LGFVGAGLGLTIARYIGAIATIW-VLMVGLNPALRLSlkgYFKPfNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAG 288
Cdd:cd13145 188 MGVSGIALATIISQFIGMFYLLYkVRKSGIISGCRLR---DFIP-RLDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQ 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 289 MGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQ---IGQAEFQAWHVFWLSTIILTLIAWgsaPFAGFIAS 365
Cdd:cd13145 264 FGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKydrVRETYKKALKYGFVIMVVATVFLL---FFAEPLMS 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 366 FYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLgmwgcRVVAG-----YTLGIVLGMGVIGV 440
Cdd:cd13145 341 LFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLY-----RQLVGpalvfWLLVNVLGLGVTGI 415
|
....*.
gi 490253468 441 WLGMVL 446
Cdd:cd13145 416 WWGIFT 421
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
54-446 |
9.46e-20 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 91.03 E-value: 9.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 54 FLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLAIMTLFSILLAGVIHAFGQEI 133
Cdd:cd13143 30 FVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFSTALLLSLILGLLLTILGLLFLDPL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 134 IDFVAgdATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILNILISSVLIYgifsWPGLGFV 213
Cdd:cd13143 110 LRLLG--ASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIF----VLGLGIA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 214 GAGLGLTIARYIGAIATIWVLMVGlNPALRLSLKgyFKPFNFAIIWEVMGIGIPASIESVLFN-GGKLLTQMFVAGMGTN 292
Cdd:cd13143 184 GAALATVIAQLISLLLLLLYFFRG-KSLLKLSLL--RFKLSLKIIKEILALGFPSFLMQLSSSvVTIVLNLTLLGYGGDI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 293 VIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIAWGSAPFAGFIASFYTHEED 372
Cdd:cd13143 261 GVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPE 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490253468 373 VKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYTLGIVlgMGVIGVWLGMVL 446
Cdd:cd13143 341 LIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRL--FGLDGIWLAFPL 412
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
29-446 |
1.08e-19 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 91.09 E-value: 1.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 29 REISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSF-NMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFaNVTGFSILLGLASALDTLCGQAFGAKNYKLVGVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 108 ARQSLAIMTLFSILLAgVIHAFGQEIIDFVAGDAtaQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLING 187
Cdd:cd13132 83 LQRALVILLLCCVPIS-LLWLNTEPILLLLGQDP--EIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 188 GMNILNILISSVLIYGifswPGLGFVGAGLGLTIARYIGAIATIWVLMVGlnpALRLSLKGYFKPFNFAIIWEVMGIGIP 267
Cdd:cd13132 160 VALLLNILLNYLLVFV----LGLGFIGAALATSISYWLIVVLLLLYIFFS---KGHKATWGGFSREAFRGWGPFLKLAIP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 268 ASI----ESVLFNGGKLLTQMFVagmGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFW 343
Cdd:cd13132 233 SALmlclEWWAFEILVLLAGLLP---GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALI 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 344 LSTIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRV 423
Cdd:cd13132 310 LSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGL 389
|
410 420
....*....|....*....|...
gi 490253468 424 VAGYTLGIVLGMGVIGVWLGMVL 446
Cdd:cd13132 390 PVGLLLAFVLGLGLKGLWIGLIA 412
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-381 |
1.61e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 87.76 E-value: 1.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLA 113
Cdd:cd13141 16 MALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 114 IMTLFSILLAGVIHAFGQEIIDFVAGDatAQVKDLALTYLE--LTALSYPAAAIALigSGALRGAGTTKIPLLINGGMNI 191
Cdd:cd13141 96 LAAVLGLVVLVLGYLFGRLYLETLAAD--AATVEAATTYLYwfIPSLALQFILTVL--GAALRGTGIVKPFMVIQILAVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 192 LNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLM-----VGLNPALrlslkgyFKPfNFAIIWEVMGIGI 266
Cdd:cd13141 172 LNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLrlekyLRLDLAL-------WRP-DLPTWKRLLKIGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 267 PASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLST 346
Cdd:cd13141 244 PSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTT 323
|
330 340 350
....*....|....*....|....*....|....*
gi 490253468 347 IILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLL 381
Cdd:cd13141 324 ALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFL 358
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-463 |
2.12e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 87.33 E-value: 2.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVI-MSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSL 112
Cdd:cd13148 17 LALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTqMMSNGAMGGGVSSAIARALGAGDRERAEALVWHAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 113 AIMTLFSILLAGVIHAFGQEIIDFVAGdaTAQVKDLALTYleltALSYPAAAIAL----IGSGALRGAGTTKIPLLINGG 188
Cdd:cd13148 97 VIALAGGLVFSLLFLLFGPALYRLLGG--RGEALDAALAY----SNVLFSGAILIwlvnLLAAALRGTGNMRVPALVTLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 189 MNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMVGLNpalRLSLKGYFKPFNFAIIWEVMGIGIPA 268
Cdd:cd13148 171 GAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRS---RLRLRLRALRLERRLFRDILRVGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 269 SIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTII 348
Cdd:cd13148 248 ALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 349 LTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMwGCRVVAGYT 428
Cdd:cd13148 328 AGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGTLRL-LIAAGGGWI 406
|
410 420 430
....*....|....*....|....*....|....*
gi 490253468 429 LGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGR 463
Cdd:cd13148 407 AVALFGAGLAGLFAAAAAAMVAYGLVTAAAVKLGA 441
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
18-232 |
7.62e-18 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 85.58 E-value: 7.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 18 KKRQRYRVLYWREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLG 97
Cdd:COG0534 218 LRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLG 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 98 KRDRRRARAAARQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDatAQVKDLALTYLELTALSYPAAAIALIGSGALRGAG 177
Cdd:COG0534 298 AGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDD--PEVIALAATYLRIAALFQPFDGLQFVLSGALRGAG 375
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 490253468 178 TTKIPLLInggmNILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIW 232
Cdd:COG0534 376 DTRFPMII----SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLL 426
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
267-418 |
1.99e-14 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 70.67 E-value: 1.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 267 PASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLST 346
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490253468 347 IILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGM 418
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL 152
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-446 |
1.53e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 72.43 E-value: 1.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEA---MAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQ 110
Cdd:cd13146 13 LALPILIGQLFQLLYNITDTIWISMIDPSDpalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 111 SLAIMTLFSILLAGVIHAFGQEIIDFVAGdataqvKDLALTY-LELTALSYPAAAIALIGS---GALRGAGTTKIPLLIN 186
Cdd:cd13146 93 GLALALLAATVIVVLGYIFAEPLLQLLGA------KGLLLEYaLEYFYYSLPGVPFIMLIGvlmGVLQGEGRTKYMMMAM 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 187 GGMNILNILISSVLIYGIfswpGLGFVGAGLGLTIARYIGAIATIWVLMVGlnpALRLSLKGYFKPFNFAIIWEVMGIGI 266
Cdd:cd13146 167 LIGTVVNIVLDPILIFVF----DMGVKGAALATVLAQAISLLYLLYVFLIG---KSNVTIHIKLSNISSSVIVEILRVGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 267 PASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAeFQAWHV-FWLS 345
Cdd:cd13146 240 PQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRM-LQILMTaVILG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 346 TIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVA 425
Cdd:cd13146 319 IVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPV 398
|
410 420
....*....|....*....|.
gi 490253468 426 GYTLGIVLGMGVIGVWLGMVL 446
Cdd:cd13146 399 VYLLAYVFGKGITGVYFGIVS 419
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
257-470 |
1.26e-12 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 69.40 E-value: 1.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 257 IIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEF 336
Cdd:COG0534 6 ILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 337 QAWHVFWLSTIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSML 416
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 490253468 417 GMwGCRVVAGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRWLWKYPR 470
Cdd:COG0534 166 GN-VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRL 218
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-454 |
4.72e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 67.64 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLA 113
Cdd:cd13144 13 MSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 114 iMTLFSILLAGVIHAFGQEIIdFVAGDATAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILN 193
Cdd:cd13144 93 -LALLSYLLFLLLGLFGVKPF-FRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIIN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 194 ILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATIWVLMvGLNPALRLSLKGyFKPfNFAIIWEVMGIGIPASIESV 273
Cdd:cd13144 171 IILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLL-RKNKDVQPDLRL-FRP-SLRIIKEIYAVGLPSIIMQA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 274 LFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLSTIILTLIA 353
Cdd:cd13144 248 ISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 354 WGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMWGCRVVAGYTLGIVL 433
Cdd:cd13144 328 LLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWLLAKMF 407
|
410 420
....*....|....*....|.
gi 490253468 434 gmGVIGVWLGMVLDWAVRGVL 454
Cdd:cd13144 408 --GLNGVWWSFPIAEIVSFLL 426
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
34-457 |
1.53e-07 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 53.60 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 34 LAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGL-ADSFNMVIMSFFAAID-LGTTVVVAFSLGKRDRRRARAAARQS 111
Cdd:PRK00187 15 LAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVSIFCVGVIAaVGTLVAIRHGAGDIEGATRLAQAGLW 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 112 LA-IMTLFSIL----LAGVIHAFGQeiidfvagdaTAQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLIN 186
Cdd:PRK00187 95 LAwLLALVAALllwnLKPLLLLFGQ----------APQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVIS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 187 GGMNILNILISSVLIYGIFSWPGLGFvgAGLGLTIARYIGAIATIWVLMVGLNPALRLS--LKGYFKPfNFAIIWEVMGI 264
Cdd:PRK00187 165 LAGAVANLLLNYALIEGWFGLPKLGL--MGIGLVTALVSNGMALALALYIRRHPAYAAYplRKGLSRP-SRAALRELWRL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 265 GIPA----SIESVLFNGGKLLtqmfVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWH 340
Cdd:PRK00187 242 GLPIggtyAVEVGLFTFAALC----MGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 341 VFWLSTIILTLIAWGSAPFAGFIASFYTHEED-----VKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSM 415
Cdd:PRK00187 318 GIGFGAVVMLLFAGLFWLLPEAIIGLFLDRNDpafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGL 397
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 490253468 416 LGMWGCRVVAGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYF 457
Cdd:PRK00187 398 ACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
267-417 |
1.96e-07 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 53.02 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 267 PASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLST 346
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490253468 347 IILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLG 417
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIG 151
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
266-465 |
6.10e-07 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 51.56 E-value: 6.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 266 IPASIESVLFNGGKLLTQMFVAGMGTNVIAGNFIAFSVASLINLPGNALGSASTIITGKRLGKGQIGQAEFQAWHVFWLS 345
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 346 TIILTLIAWGSAPFAGFIASFYTHEEDVKEVVKQLLWLNALFMPIWSLSWTLPCAFKGARDVRYTMWVSMLGMwGCRVVA 425
Cdd:cd12082 82 ILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSN-LLNILL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 490253468 426 GY---TLGIVLGMGVIGVWLGMVLDWAVRGVLFYFRMVSGRWL 465
Cdd:cd12082 161 DPlliFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKI 203
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
27-231 |
2.75e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 46.55 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 27 YWREISPLAVPILLENACVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRAR 105
Cdd:cd12082 217 LLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAaFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRAR 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 106 AAARQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDAtaQVKDLALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLI 185
Cdd:cd12082 297 RITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDP--EFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIV 374
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 490253468 186 NggmnILNILISSVLIYGIFSWPGLGFVGAGLGLTIARYIGAIATI 231
Cdd:cd12082 375 S----LLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLL 416
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
7-221 |
1.13e-04 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 44.47 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 7 VRQAVERTSWFKKRQRYRVLYWREISPLAVPILLENACVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDL 86
Cdd:cd13136 203 LRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAY 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 87 GTTVVVAFSLGKRDRRRARAAARQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDATaqVKDLALTYLELTALSYPAAAIA 166
Cdd:cd13136 283 AAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPA--VLALAATYLPWLALLPPIGALA 360
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 490253468 167 LIGSGALRGAGTTKIpllinggmnILNILISSVLIYGIFSW---PGLGFVGAGLGLTI 221
Cdd:cd13136 361 FVLDGIFIGATDTRY---------LRNSMLVSLAVFLPLLFllvPLWGNHGLWLALIL 409
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-234 |
1.96e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 40.60 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 13 RTSWFKKRQRYRVLYWREISPLAVPILLENACVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMSFFAAIdlGTTVV 91
Cdd:cd13128 190 KKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGyFLGDAAVGIYNAAYRIAELLLFIPSAI--STALF 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 92 VAFS-LGKRDRRRARAAARQSLAIMTLFSILLAGVIHAFGQEIIDFVAGDATAQvkdlALTYLELTALSYPAAAIALIGS 170
Cdd:cd13128 268 PRISeLYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP----AALVLQILAWGFLFIFLNGIFG 343
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490253468 171 GALRGAGTTKIPLLINGGMNILNILISSVLIygifswPGLGFVGAGLGLTIARYIGAIATIWVL 234
Cdd:cd13128 344 SILQAIGKQKLTLKILLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
35-231 |
4.04e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 39.55 E-value: 4.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 35 AVPILLENACVLLMGVLSTFLVSWLGKEAMAGV-GLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLA 113
Cdd:COG2244 179 SLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALR 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253468 114 IMTLFSILLAGVIHAFGQEIIDFVAGDATAQvkdlALTYLELTALSYPAAAIALIGSGALRGAGTTKIPLLINGGMNILN 193
Cdd:COG2244 259 LLLLLGLPLALGLALLAPPLLSLLFGPEYAE----AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLN 334
|
170 180 190
....*....|....*....|....*....|....*...
gi 490253468 194 ILISSVLIygifswPGLGFVGAGLGLTIARYIGAIATI 231
Cdd:COG2244 335 LVLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| |
