|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
1-433 |
0e+00 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 870.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 1 MKKLFVQFYLLLFVCFLVMTMLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPRDWSKTLKELDLNLSFDLHIE 80
Cdd:PRK10604 1 MRKLFIQFYLLLFVCFLVMTLLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPRDWGKTLKEMDLNLSFDLRIE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 81 PISKFKLSESSMQHLRAGDIVALDDQYTFIQRIPRSHYVLSVGPVPYLYFLHEMRLLDVALMAFIAISLAFPVFIWMRPH 160
Cdd:PRK10604 81 PLSKYHLDPASQQRLREGEIVALDDQYTFLQRIPRSHYVLAVGPVPYLYYLHQMRLLDIALLALIGLSLAFPVFLWMRPH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 161 WQDMLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSENL 240
Cdd:PRK10604 161 WQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 241 TEAESQALNRDIGQLEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGNYGALDMRLM 320
Cdd:PRK10604 241 SAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 321 ERVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQA 400
Cdd:PRK10604 321 ERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALA 400
|
410 420 430
....*....|....*....|....*....|...
gi 490253565 401 MGGEVRCEASPLGGARFCFSWPVYHQLPDFTSA 433
Cdd:PRK10604 401 MGGSVNCDESELGGARFSFSWPVWHNLPQFTSA 433
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-423 |
2.37e-56 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 181.09 E-value: 2.37e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQ 399
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 490253565 400 AMGGEVRCEASPLGGARFCFSWPV 423
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
128-423 |
7.51e-56 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 187.81 E-value: 7.51e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 128 LYFLHEMRLLDVALMAFIAISLAFPVFIWMRPHWQDMLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINA 207
Cdd:COG0642 26 LLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 208 LIASKKQLIDGIAHELRTPLVRLRYRLEM-SENLTEAESQALN---RDIGQLEALIEELLTYARLDRPQTELSLTTPDFP 283
Cdd:COG0642 106 ANEAKSRFLANVSHELRTPLTAIRGYLELlLEELDEEQREYLEtilRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 284 AWISDHVEDIQMVNPQREVALATLTHGNYGAL--DMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGP 359
Cdd:COG0642 186 ELLEEVVELFRPLAEEKGIELELDLPDDLPTVrgDPDRLRQVLLNLLSNAIKYTPEggTVTVSVRREGDRVRISVEDTGP 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490253565 360 GIAPEERERVFEPFVRLDPSrdRATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG0642 266 GIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
87-426 |
1.33e-55 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 188.99 E-value: 1.33e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 87 LSESSMQHLRAGDIVALDDQYTFIQRIPRSHYVLSVGPVPYLYFLHEMRLLDVALMAFIAISLAFPVFIWMRPHWQDMLR 166
Cdd:COG5002 40 LLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 167 IETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM----SENLTE 242
Cdd:COG5002 120 LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELlldgAADDPE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 243 AESQALNR---DIGQLEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGNYGAL--DM 317
Cdd:COG5002 200 ERREYLEIileEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlgDP 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 318 RLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVH 395
Cdd:COG5002 280 DRLEQVLTNLLDNAIKYTPEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVK 359
|
330 340 350
....*....|....*....|....*....|.
gi 490253565 396 SIAQAMGGEVRCEASPLGGARFCFSWPVYHQ 426
Cdd:COG5002 360 HIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
197-423 |
2.23e-54 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 180.87 E-value: 2.23e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM---SENLTEAESQAL----NRDIGQLEALIEELLTYARLD 269
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELlldEEDLSPEERRELleiiRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 270 RPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGN--YGALDMRLMERVLDNLVNNALRYSSQ--RVAVSLTL 345
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElpLVYADPELLEQVLANLLDNAIKYSPPggTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490253565 346 QGSRASLLVEDDGPGIAPEERERVFEPFVRLDpsRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
109-425 |
3.02e-46 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 165.88 E-value: 3.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 109 FIQRIPRSHYVLSVG-PV--PYLYFLHemRLLDVALMAFIAISLA-FPVFIWMRphW---QDMLRIETAAQRFGEGHLse 181
Cdd:PRK09470 136 FSVRDGEDNYQLYLIrPAnsPQSDFIN--LLFDRPLLLLLVTMLVsTPLLLWLA--WslaKPARKLKNAADEVAQGNL-- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 182 RIHFD---SMSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRL-------RYRLEMSENLTEAESQALnrd 251
Cdd:PRK09470 210 RQHPEletGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLqlatallRRRQGESKELERIETEAQ--- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 252 igQLEALIEELLTyarLDRPQTELSLTTPDFPA---WiSDHVEDIQMVNPQREVALATLTH-------GNYGALDmrlme 321
Cdd:PRK09470 287 --RLDSMINDLLV---LSRNQQKNHLERETFKAnslW-SEVLEDAKFEAEQMGKSLTVSAPpgpwpinGNPNALA----- 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 322 RVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQAM 401
Cdd:PRK09470 356 SALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
330 340
....*....|....*....|....
gi 490253565 402 GGEVRCEASPLGGARFCFSWPVYH 425
Cdd:PRK09470 436 RGWVKAEDSPLGGLRLTIWLPLYK 459
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
141-419 |
1.22e-41 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 152.76 E-value: 1.22e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 141 LMAFIAISLAFpvfIWMRPHWQD--MLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLIDG 218
Cdd:PRK09467 159 TLAIGLLSVAG---GWLFIRIQNrpLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAG 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 219 IAHELRTPLVRLRYRLEM--SENLTEAESqaLNRDIGQLEALIEELLTYARLDRpqtELSLTTPDfpawISDHVEDIQMV 296
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMmsEEDGYLAES--INKDIEECNAIIEQFIDYLRTGQ---EMPMEMAD----LNALLGEVIAA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 297 NPQREVALATltHGNYGALDMRL----MERVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEP 372
Cdd:PRK09467 307 ESGYEREIET--ALQPGPIEVPMnpiaIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQP 384
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 490253565 373 FVRLDpsRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLGG--ARFCF 419
Cdd:PRK09467 385 FTRGD--SARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGlsARAWL 431
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
136-422 |
6.41e-37 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 140.35 E-value: 6.41e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 136 LLDVALMAFIAISLAFPVFIWMRphwQDMLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQL 215
Cdd:NF012163 167 WLIVALALLLAALAAFLLARGLL---APVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDF 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 216 IDGIAHELRTPLVRLRYRLEMSEN----LTEAESQALNRDIGQLEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVE 291
Cdd:NF012163 244 MADISHELRTPLAVLRAELEAIQDgirkFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGG 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 292 DIQMVNPQREVALATLTHGNYGAL-DMRLMERVLDNLVNNALRY--SSQRVAVSLTLQGSRASLLVEDDGPGIAPEERER 368
Cdd:NF012163 324 AFRERFASAGLELEVSLPDSSLVFgDRDRLMQLFNNLLENSLRYtdSGGSLHISASQRPKEVTLTVADSAPGVSDEQLAR 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 490253565 369 VFEPFVRLDPSRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:NF012163 404 LFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
170-422 |
3.50e-35 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 136.31 E-value: 3.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 170 AAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIAS-------KKQLIDGIAHELRTPLVRLRyrleMSENL-- 240
Cdd:NF040691 222 TAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLTTIR----MAADVih 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 241 ---------TEAESQALNRDIGQLEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGN 311
Cdd:NF040691 298 dsrddfdpaTARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGT 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 312 YGALDM--RLMERVLDNLVNNALRYSSQR-VAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCG 388
Cdd:NF040691 378 PVVAEVdpRRVERVLRNLVVNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTG 457
|
250 260 270
....*....|....*....|....*....|....
gi 490253565 389 LGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:NF040691 458 LGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
147-423 |
1.40e-34 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 133.16 E-value: 1.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 147 ISLAFPVFIWMRPHWQDMLRIetaaQRFGEGHLSERIhfdsmSSFERLG--VAFnqmaDNINALIASKK-----QLIDGI 219
Cdd:COG5000 142 LDLAELLREALERGWQEEIEL----TRDGRRTLLVRA-----SPLRDDGyvIVF----DDITELLRAERlaawgELARRI 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 220 AHELRTPL---------VRLRYRLEMSENLTEAES--QALNRDIGQLEALIEELLTYARLDRPQTELSlttpDFPAWISD 288
Cdd:COG5000 209 AHEIKNPLtpiqlsaerLRRKLADKLEEDREDLERalDTIIRQVDRLKRIVDEFLDFARLPEPQLEPV----DLNELLRE 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 289 HVEDIQMVNPQREVALATLTHGN--YGALDMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPE 364
Cdd:COG5000 285 VLALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLINLLKNAIEAIEEggEIEVSTRREDGRVRIEVSDNGPGIPEE 364
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490253565 365 ERERVFEPFVrldpsrdraT---GGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG5000 365 VLERIFEPFF---------TtkpKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
219-423 |
1.05e-33 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 132.22 E-value: 1.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 219 IAHELRTPLVRLRY---RLEM--SENLTEAESQALNR---DIGQLEALIEELLTYARLDRpqTELSLTTPDFPAWISDHV 290
Cdd:COG4251 289 ASHDLREPLRKISGfsqLLEEdyGDKLDEEGREYLERirdAAERMQALIDDLLAYSRVGR--QELEFEPVDLNELLEEVL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 291 EDIQMVNPQREvalATLTHGNYGAL--DMRLMERVLDNLVNNALRYSSQ----RVAVSLTLQGSRASLLVEDDGPGIAPE 364
Cdd:COG4251 367 EDLEPRIEERG---AEIEVGPLPTVrgDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPE 443
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 490253565 365 ERERVFEPFVRLDPSRDRatGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG4251 444 YAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
99-422 |
1.19e-33 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 131.36 E-value: 1.19e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 99 DIVALDDQYTFiQRIPRSHYVLSVGpvpyLYFLHEMRLLD------VALMAFIAISLAFPVFIWMRPHWQDMLRIETAAQ 172
Cdd:TIGR01386 126 RSILRSVAALP-GGKGRKPVQITVA----LDINAHTHLLDalrkwlILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAA 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 173 RFGEGHLSERIHFDSMSS-FERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRL---------------RYRLEM 236
Cdd:TIGR01386 201 RISPESLDQRLDPSRAPAeLRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLlgqtqvalsqprtgeEYREVL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 237 SENLTEaesqaLNRdigqLEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALatLTHGNYGAL- 315
Cdd:TIGR01386 281 ESNLEE-----LER----LSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRI--RVEGEGLVRg 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAI 393
Cdd:TIGR01386 350 DPQMFRRAISNLLSNALRHTPDggTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAI 429
|
330 340
....*....|....*....|....*....
gi 490253565 394 VHSIAQAMGGEVRCEaSPLGGARFCFSWP 422
Cdd:TIGR01386 430 VRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
316-423 |
1.67e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 121.60 E-value: 1.67e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPsRDRATGGCGLGLAI 393
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 490253565 394 VHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
94-423 |
6.31e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 121.83 E-value: 6.31e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 94 HLRAGDIVALDDQYTFIQRIPRSHYVLSVGPVPYLYFLHEMRLLDVALMAFIAISLAFPVFIWMRPHWQDMLRIETAAQR 173
Cdd:COG4191 12 LALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 174 FGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLID------------GIAHELRTPLVRLRYRLEMSENLT 241
Cdd:COG4191 92 ALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQseklaalgelaaGIAHEINNPLAAILGNAELLRRRL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 242 EAE------SQALNRDIGQLE---ALIEELLTYARLDRPQTElslttpdfPAWISDHVED-IQMVNPQ---REVALATLT 308
Cdd:COG4191 172 EDEpdpeelREALERILEGAEraaEIVRSLRAFSRRDEEERE--------PVDLNELIDEaLELLRPRlkaRGIEVELDL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 309 HGNYGAL--DMRLMERVLDNLVNNAL----RYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVrldpSRDR 382
Cdd:COG4191 244 PPDLPPVlgDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF----TTKP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490253565 383 ATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG4191 320 VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
4.22e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 112.42 E-value: 4.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQ 399
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 490253565 400 AMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
316-423 |
8.33e-29 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 108.99 E-value: 8.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQRVAVSLTL-QGSRASLLVEDDGPGIAPEERERVFEPFVRLDpsrDRATGGCGLGLAIV 394
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLsEGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*....
gi 490253565 395 HSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
170-420 |
1.16e-28 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 115.48 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 170 AAQRFGEGHLSERIHFDSMSSFE--RLGVAFNQMADNI-----NALIASKkqlidGIAHELRTPLVRLRYRLE-MSENLT 241
Cdd:NF012226 94 AAKKISQGDLSARAEDSQIHSAEisELMHNFNDMAQKLessvkNAQVWNA-----AIAHELRTPITILQGRLQgILDGVF 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 242 EAEsQALNRD-IGQLEA---LIEELLTYARLDRPQTELSLTTPDFpawiSDHVED-IQM---------VNPQREVAlATL 307
Cdd:NF012226 169 EPD-PALFKSlLNQVEGlshLVEDLRTLSLVENQQLRLNYESVDL----KDSIEKvLKMfedrleqaqLTIVLNLT-ATP 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 308 THgnygaLDMRLMERVLDNLVNNALRYSSQ-RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGG 386
Cdd:NF012226 243 VF-----CDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGG 317
|
250 260 270
....*....|....*....|....*....|....
gi 490253565 387 CGLGLAIVHSIAQAMGGEVRCEASplgGARFCFS 420
Cdd:NF012226 318 TGLGLAVVHAIVIAHKGSIEYSNS---QGNSVFT 348
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
219-419 |
2.08e-28 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 114.23 E-value: 2.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 219 IAHELRTPLVRLRYRLEMSENLTEAESQALNRDIGQ-------LEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVE 291
Cdd:TIGR02966 121 VSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEImleqsqrMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRD 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 292 DIQMVNPQREVALATLTHGN---YGALDmRLMErVLDNLVNNALRYS--SQRVAVSLTLQGSRASLLVEDDGPGIAPEER 366
Cdd:TIGR02966 201 EAEALSQGKNHQITFEIDGGvdvLGDED-ELRS-AFSNLVSNAIKYTpeGGTITVRWRRDGGGAEFSVTDTGIGIAPEHL 278
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 490253565 367 ERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCF 419
Cdd:TIGR02966 279 PRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSF 331
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
166-428 |
6.92e-28 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 115.12 E-value: 6.92e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 166 RIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSEN----LT 241
Cdd:PRK10549 194 RLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDgvrkFT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 242 EAESQALNRDIGQLEALIEELltyarldrpqTELSLTTPDFPAWISDHVEDIQMVnpqrEVALATLtHGNYGA----LDM 317
Cdd:PRK10549 274 PESVASLQAEVGTLTKLVDDL----------HQLSLSDEGALAYRKTPVDLVPLL----EVAGGAF-RERFASrgltLQL 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 318 RLMERV------------LDNLVNNALRY--SSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRA 383
Cdd:PRK10549 339 SLPDSAtvfgdpdrlmqlFNNLLENSLRYtdSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRA 418
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 490253565 384 TGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPVYHQLP 428
Cdd:PRK10549 419 SGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-418 |
1.10e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 102.91 E-value: 1.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDraTGGCGLGLAIVHSIAQ 399
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|.
gi 490253565 400 AMGGEVRCEASPLGG--ARFC 418
Cdd:cd16950 79 AHGGSLTLANRAGGGlcARIE 99
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-422 |
1.65e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 102.54 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYS----SQRVAVSLTLQGSRasLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGL 391
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTdtggKLRIRAAQTPQEVR--LDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 490253565 392 AIVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
114-422 |
6.58e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 109.48 E-value: 6.58e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 114 PRSHYVLSVGPVP--YLYFLHEMRLLDVALMAFIAISLAFPVFIWMRPHWQDMLRIETAAQRFGEGHLSERIHFDSMS-S 190
Cdd:PRK09835 161 GKPIYTLLIALSIdfHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiE 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 191 FERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSenLTEAESQALNRDI--------GQLEALIEEL 262
Cdd:PRK09835 241 LEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIA--LSQSRSQKELEDVlysnleelTRMAKMVSDM 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 263 LTYARLDRPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGNYGALDMRLMERVLDNLVNNALRYS--SQRVA 340
Cdd:PRK09835 319 LFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTpaGEAIT 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 341 VSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQAMGGEVRCEaSPLGGARFCFS 420
Cdd:PRK09835 399 VRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVT-SDARGTRFVIS 477
|
..
gi 490253565 421 WP 422
Cdd:PRK09835 478 LP 479
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
323-423 |
1.51e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 99.87 E-value: 1.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 323 VLDNLVNNALRYSSQ-RVAVSLTLQGS-----RASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHS 396
Cdd:cd16922 4 ILLNLLGNAIKFTEEgEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90 100
....*....|....*....|....*..
gi 490253565 397 IAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:cd16922 84 LVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
213-425 |
2.05e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 106.47 E-value: 2.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 213 KQLIDGIAHELRTPLVRLRYRLE-MSENLTEAESQALNRDIGQ----LEALIEELLTYARLDRPQTE-----------LS 276
Cdd:COG3852 136 GELAAGLAHEIRNPLTGIRGAAQlLERELPDDELREYTQLIIEeadrLNNLVDRLLSFSRPRPPEREpvnlhevlervLE 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 277 LTTPDFPAWIS---DHVEDIQMVNpqrevalatlthgnygaLDMRLMERVLDNLVNNALRYSSQ--------RVAVSLTL 345
Cdd:COG3852 216 LLRAEAPKNIRivrDYDPSLPEVL-----------------GDPDQLIQVLLNLVRNAAEAMPEggtitirtRVERQVTL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 346 QGSRASLL----VEDDGPGIAPEERERVFEPFVRldpSRDRATGgcgLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSW 421
Cdd:COG3852 279 GGLRPRLYvrieVIDNGPGIPEEILDRIFEPFFT---TKEKGTG---LGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
....
gi 490253565 422 PVYH 425
Cdd:COG3852 353 PLEQ 356
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-417 |
4.18e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 94.24 E-value: 4.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 319 LMErVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIA 398
Cdd:cd16954 38 LME-LLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIV 112
|
90
....*....|....*....
gi 490253565 399 QAMGGEVRCEASPLGGARF 417
Cdd:cd16954 113 EQYGGELSLSDSPLGGARF 131
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-421 |
4.98e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 93.24 E-value: 4.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 319 LMERVLDNLVNNALRYSSQRVAVSLTLQGSRASLL-VEDDGPGIAPEERERVFEPFVRLDPsrdRATGGCGLGLAIVHSI 397
Cdd:cd16940 13 LLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIrVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 490253565 398 AQAMGGEVRCEASPLGGARFCFSW 421
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
68-423 |
1.13e-22 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 100.87 E-value: 1.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 68 ELDLNLSFDLHIEPISKFKLSESSMQHLRAG-DIVALDDQYtfiQRIPrSHYVLSV---GP-------VPYLYFLHE--- 133
Cdd:PRK15347 218 DINLWLDQNGELLPFSTIPLSSNQLQKILNQlENVKLHDGW---QQIP-DYLVLRTqlkGPgwqqvtlYPRRNLANEalk 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 134 --MRLLDVALMAFIAISLafpVFIWM------RPHWQDMLRIETAAQRFGEGHLSERIHfDSMSSFERlgvAFNQMADNI 205
Cdd:PRK15347 294 paLQQLPFALLILVLLTS---VLFLLlrrylaKPLWRFVDIINKTGPAALEPRLPENRL-DELGSIAK---AYNQLLDTL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 206 N---------------ALIASKKQL----------IDGIAHELRTPLVRLRYRLEMSENLTEAESQALNRDIGQ-----L 255
Cdd:PRK15347 367 NeqydtlenkvaertqALAEAKQRAeqankrksehLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARqctlsL 446
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 256 EALIEELLTYARLDRPQTELSL-TTPDFPAwISDHVEDIQMVNPQREVALATLTHGN---YGALD-MRLmERVLDNLVNN 330
Cdd:PRK15347 447 LAIINNLLDFSRIESGQMTLSLeETALLPL-LDQAMLTIQGPAQSKSLTLRTFVGAHvplYLHLDsLRL-RQILVNLLGN 524
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 331 ALRYSSQ-RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRdratGGCGLGLAIVHSIAQAMGGEVRCEA 409
Cdd:PRK15347 525 AVKFTETgGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHS----QGTGLGLTIASSLAKMMGGELTLFS 600
|
410
....*....|....
gi 490253565 410 SPLGGARFCFSWPV 423
Cdd:PRK15347 601 TPGVGSCFSLVLPL 614
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
197-408 |
3.41e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 96.96 E-value: 3.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSENLTEAESQALNRDIGQLEALIEELLTYARLDRPQTELS 276
Cdd:PRK10755 122 ALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGH 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 277 LTTPDfpaWISDHV----EDIQMVNPQREVAL------ATLT-HGNygALDMRLMERvldNLVNNALRYSSQ--RVAVSL 343
Cdd:PRK10755 202 YQTVK---LLEDVIlpsqDELSEMLEQRQQTLllpesaADITvQGD--ATLLRLLLR---NLVENAHRYSPEgsTITIKL 273
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490253565 344 TLQGSRASLLVEDDGPGIAPEERERVFEPFVRLdpsrDRATGGCGLGLAIVHSIAQAMGGEVRCE 408
Cdd:PRK10755 274 SQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
197-421 |
8.74e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 93.95 E-value: 8.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSEnLTEAESQALNRDIGQLEA-------LIEELLTYARLD 269
Cdd:PRK10337 222 ALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAQ-LSDDDPQARKKALLQLHAgidratrLVDQLLTLSRLD 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 270 rpqtelSLttpdfpawisDHVEDIQMVNPQ---REVALATLTHGNYGALDMR---------------LMERVLDNLVNNA 331
Cdd:PRK10337 301 ------SL----------DNLQDVAEIPLEdllQSAVMDIYHTAQQAGIDVRltlnahpvirtgqplLLSLLVRNLLDNA 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 332 LRYSSQRVAVSLTLqgSRASLLVEDDGPGIAPEERERVFEPFVRldPSRDRATGGcGLGLAIVHSIAQAMGGEVRCEASP 411
Cdd:PRK10337 365 IRYSPQGSVVDVTL--NARNFTVRDNGPGVTPEALARIGERFYR--PPGQEATGS-GLGLSIVRRIAKLHGMNVSFGNAP 439
|
250
....*....|
gi 490253565 412 LGGARFCFSW 421
Cdd:PRK10337 440 EGGFEAKVSW 449
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
219-422 |
9.16e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 93.92 E-value: 9.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 219 IAHELRTPLVRLRYRLEMSENlTEAESQALNRDIG-------QLEALIEELLTYARLD-RPQTELSlTTPDFPAWIsdhv 290
Cdd:PRK11006 211 VSHELRTPLTVLQGYLEMMQD-QPLEGALREKALHtmreqtqRMEGLVKQLLTLSKIEaAPTIDLN-EKVDVPMML---- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 291 ediQMVnpQREVAlaTLTHGNYG---ALDMRLmeRVL----------DNLVNNALRYSSQ--RVAVSLTLQGSRASLLVE 355
Cdd:PRK11006 285 ---RVL--EREAQ--TLSQGKHTitfEVDNSL--KVFgnedqlrsaiSNLVYNAVNHTPEgtHITVRWQRVPQGAEFSVE 355
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 356 DDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIV-HSIAQAmggEVRCE-ASPLG-GARFCFSWP 422
Cdd:PRK11006 356 DNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVkHALSHH---DSRLEiESEVGkGTRFSFVLP 422
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
181-423 |
1.45e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 94.72 E-value: 1.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 181 ERIHFDSMSSFERLGVAFNQMAdniNALIASkkqlidgIAHELRTPLVRLRYRLEM------SENLTEAEsQA--LNRDI 252
Cdd:PRK10490 643 ERLTLTASEEQARLASEREQLR---NALLAA-------LSHDLRTPLTVLFGQAEIltldlaSEGSPHAR-QAseIRQQV 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 253 GQLEALIEELLTYARLDRPQTELSLttpdfpAWISdhVEDI-----QMVNP---QREVALA-----TLTHGnygalDMRL 319
Cdd:PRK10490 712 LNTTRLVNNLLDMARIQSGGFNLRK------EWLT--LEEVvgsalQMLEPglsGHPINLSlpeplTLIHV-----DGPL 778
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQR--VAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDpsRDRATGGCGLGLAIVHSI 397
Cdd:PRK10490 779 FERVLINLLENAVKYAGAQaeIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAI 856
|
250 260
....*....|....*....|....*.
gi 490253565 398 AQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:PRK10490 857 VEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
316-422 |
9.36e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 84.08 E-value: 9.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQRVAVSLTLQ---GSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLA 392
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkfrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 490253565 393 IVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
133-423 |
2.24e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 89.90 E-value: 2.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 133 EMRLLDVALMAFIAISLAFPVFIW--MRPhwqdMLRIETAAQRFGEGhlsERIHFDSMSSFE--RLGVAFNQMADNINAl 208
Cdd:PRK11100 181 ERRILWAGALLLGIALLIGAGVVWwlNRS----IRRLTRYADAVTEG---KPVPLPKLGSSElrELAQALESMRVKLEG- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 209 iaskKQLIDG----IAHELRTPLVRLRYRLE-MSENLTEAESQALNRDI----GQLEALIEELLTYARLDRPQTELSLTT 279
Cdd:PRK11100 253 ----KAYVEQyvqtLTHELKSPLAAIRGAAElLQEDPPPEDRARFTGNIltqsARLQQLIDRLLELARLEQRQELEVLEP 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 280 PDFPAWISDHVEDIQMVNPQREVALATLTHGNYGALDMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDD 357
Cdd:PRK11100 329 VALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEggTITLSAEVDGEQVALSVEDQ 408
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490253565 358 GPGIAPEERERVFEPFVRLdPSRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:PRK11100 409 GPGIPDYALPRIFERFYSL-PRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
209-424 |
4.80e-19 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 88.08 E-value: 4.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 209 IASKKQLIDGIAHELRTPL---------VRLRYRLEMSENLTEAESQALNRDIGQL---EALIEELLTYARldRPQTELS 276
Cdd:PRK09303 148 LKFKDRVLAMLAHDLRTPLtaaslaletLELGQIDEDTELKPALIEQLQDQARRQLeeiERLITDLLEVGR--TRWEALR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 277 L--TTPDFPAWISDHVEDIQMVNPQREVALAT-------LTHGnygalDMRLMERVLDNLVNNALRYS------------ 335
Cdd:PRK09303 226 FnpQKLDLGSLCQEVILELEKRWLAKSLEIQTdipsdlpSVYA-----DQERIRQVLLNLLDNAIKYTpeggtitlsmlh 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 336 --SQRVAVSltlqgsrasllVEDDGPGIAPEERERVFEPFVRLDpsRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLG 413
Cdd:PRK09303 301 rtTQKVQVS-----------ICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQ 367
|
250
....*....|.
gi 490253565 414 GARFCFSWPVY 424
Cdd:PRK09303 368 GSCFHFTLPVY 378
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
210-426 |
5.27e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 89.26 E-value: 5.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 210 ASKKQLIDGIAHELRTPLVRLR-----YRLEMSENLTEAESQALNRDIGQLEALIEELLTYARLDRPQTElslttpdfPA 284
Cdd:PRK11360 388 AALGELVAGVAHEIRNPLTAIRgyvqiWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQ--------PV 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 285 WISDHVED----IQMVNPQREVALATLTHGNYGA--LDMRLMERVLDNLVNNALRYSSQRVAVSLTLQ---GSRASLLVE 355
Cdd:PRK11360 460 SLNALVEEvlqlFQTAGVQARVDFETELDNELPPiwADPELLKQVLLNILINAVQAISARGKIRIRTWqysDGQVAVSIE 539
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490253565 356 DDGPGIAPEERERVFEPFVRLDPSrdratgGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPVYHQ 426
Cdd:PRK11360 540 DNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-419 |
2.70e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 79.81 E-value: 2.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNAL----RYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPsrdrATGGCGLGLAIVH 395
Cdd:cd16976 1 IQQVLMNLLQNALdamgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKP----VGKGTGLGLSISY 76
|
90 100
....*....|....*....|....
gi 490253565 396 SIAQAMGGEVRCEASPLGGARFCF 419
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
4.73e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.98 E-value: 4.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQRVAVS--LTLQGSRA-----SLLVEDDGPGIAPEERERVFEPFVRLDPSrdratgGCGLGLA 392
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERreLTIRTSPAddravTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 490253565 393 IVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
211-428 |
8.04e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.11 E-value: 8.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 211 SKKQLIDGIAHELRTPL------VRLRYRLEMSENlTEAESQALNRDIGQLEALIEELLTYARLDRPQTELSLTTPDF-P 283
Cdd:PRK11466 443 AKSAFLAAMSHEIRTPLygilgtAQLLADNPALNA-QRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSDEPFeP 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 284 AWISDHVedIQMVNPQREVALATLTHGNYGAL------DMRLMERVLDNLVNNALRYSSQ-RVAVSLTLQGSRASLLVED 356
Cdd:PRK11466 522 RPLLEST--LQLMSGRVKGRPIRLATDIADDLptalmgDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVED 599
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490253565 357 DGPGIAPEERERVFEPFVRLDPSRdratGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPVYHQLP 428
Cdd:PRK11466 600 SGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATA 667
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
1.97e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 77.37 E-value: 1.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQRVAVSLTLQGSRA----SLLVEDDGPGIAPEERERVFEPFVRLDPsrDRATGGCGLGLAIVH 395
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 490253565 396 SIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-422 |
8.87e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 75.70 E-value: 8.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 326 NLVNNALRYS--SQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQAMGG 403
Cdd:cd16952 7 NLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 490253565 404 EVRCEASPLGGARFCFSWP 422
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
312-411 |
9.20e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 76.40 E-value: 9.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 312 YGALDMRLMERVLDNLVNNALRYSSQRVAVSLTLQGSRASLL--VEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGL 389
Cdd:cd16947 13 YANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYidIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGL 92
|
90 100
....*....|....*....|..
gi 490253565 390 GLAIVHSIAQAMGGEVRCEASP 411
Cdd:cd16947 93 GLTITKRLAESMGGSIYVNSKP 114
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-404 |
1.07e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.12 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNALRYSSQRVAVSLT--LQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDraTGGCGLGLAIVHSI 397
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITsfLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
....*..
gi 490253565 398 AQAMGGE 404
Cdd:cd16923 79 IELHGGS 85
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
315-418 |
1.07e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 78.35 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 315 LDMRLMERVLDNLVNNALRYSSQ------RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRatggcG 388
Cdd:COG3290 277 LSDTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGEGR-----G 351
|
90 100 110
....*....|....*....|....*....|
gi 490253565 389 LGLAIVHSIAQAMGGEVRCEASPLGGARFC 418
Cdd:COG3290 352 LGLALVKQIVEKYGGTIEVESEEGEGTVFT 381
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
215-423 |
1.73e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 77.90 E-value: 1.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 215 LIDGIAHELRTPLVRL----RYRLEMSENLTEAE--SQALNRDIGQLEALIEELLtyaRLDRPqTELSLTTPDFPAWISD 288
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIkglaKYFAERAPAGGEAHqlAQVMAKEADRLNRVVSELL---ELVKP-THLALQAVDLNDLINH 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 289 HVEDIQMVNPQREVAL-----ATLTHGNygaLDMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGI 361
Cdd:PRK10364 316 SLQLVSQDANSREIQLrftanDTLPEIQ---ADPDRLTQVLLNLYLNAIQAIGQhgVISVTASESGAGVKISVTDSGKGI 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490253565 362 APEERERVFEPFVRLDPSrdratgGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:PRK10364 393 AADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-423 |
1.98e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 71.68 E-value: 1.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 319 LMERVLDNLVNNALRYSSQR--VAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDratgGCGLGLAIVHS 396
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRgrITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYR 78
|
90 100
....*....|....*....|....*..
gi 490253565 397 IAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-422 |
3.00e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 71.28 E-value: 3.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNA------------LRYSSQRvAVSLTLQGSRASLLVE--DDGPGIAPEERERVFEPFVrldPSRDratG 385
Cdd:cd16918 1 LIQVFLNLVRNAaqalagsggeiiLRTRTQR-QVTLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMV---SGRE---N 73
|
90 100 110
....*....|....*....|....*....|....*..
gi 490253565 386 GCGLGLAIVHSIAQAMGGEVRCEASPlGGARFCFSWP 422
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-417 |
3.97e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 70.78 E-value: 3.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 323 VLDNLVNNAL------RYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRatggcGLGLAIVHS 396
Cdd:cd16915 4 IVGNLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQ 78
|
90 100
....*....|....*....|.
gi 490253565 397 IAQAMGGEVRCEASPLGGARF 417
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTF 99
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
319-418 |
5.97e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 76.60 E-value: 5.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 319 LMErVLDNLVNNALRYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIA 398
Cdd:PRK10815 379 FME-VMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREIT 453
|
90 100
....*....|....*....|
gi 490253565 399 QAMGGEVRCEASPLGGARFC 418
Cdd:PRK10815 454 EQYEGKISAGDSPLGGARME 473
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-422 |
1.53e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 69.52 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 322 RVLDNLVNNALRYS---SQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIA 398
Cdd:cd16953 3 QVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 490253565 399 QAMGG----EVRCEASPLGGARFCFSWP 422
Cdd:cd16953 83 EAHGGisvaENHNQPGQVIGARFTVQLP 110
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
205-423 |
2.91e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 75.16 E-value: 2.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 205 INALIAsKKQLIDGIAHELRTPLVRLRYRLEM--SENLTE---AESQALNRDIGQ-LEALIEELLTYARLDRPQTELSLT 278
Cdd:PRK09959 706 INATVA-KSQFLATMSHEIRTPISSIMGFLELlsGSGLSKeqrVEAISLAYATGQsLLGLIGEILDVDKIESGNYQLQPQ 784
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 279 TPDFPAWISDHVEDIQMVNPQREVALA---TLTHGNYGALDMRLMERVLDNLVNNALRYSSQ---RVAVSLT-LQGSRA- 350
Cdd:PRK09959 785 WVDIPTLVQNTCHSFGAIAASKSIALScssTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEgavKITTSLGhIDDNHAv 864
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490253565 351 -SLLVEDDGPGIAPEERERVFEPFVRLDPSRDRAtgGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:PRK09959 865 iKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
219-422 |
4.91e-13 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 70.93 E-value: 4.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 219 IAHELRTPLVRLRYRLEM--SENLTEAESQALNR---DIGQLEALIEELLTYARLDrpQTELSLTTPDFPA--WISDHVE 291
Cdd:TIGR03785 492 LSHELRTPVAVVRSSLENleLQALEQEKQKYLERareGTERLSMILNNMSEATRLE--QAIQSAEVEDFDLseVLSGCMQ 569
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 292 DIQMVNPQREVALatltHGNYGALDMR----LMERVLDNLVNNALRYSSQR--VAVSLTLQGSRASLLVEDDGPGIAPEE 365
Cdd:TIGR03785 570 GYQMTYPPQRFEL----NIPETPLVMRgspeLIAQMLDKLVDNAREFSPEDglIEVGLSQNKSHALLTVSNEGPPLPEDM 645
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 490253565 366 RERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAQAMGGEVRCEASPLG-GARFCFSWP 422
Cdd:TIGR03785 646 GEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-416 |
3.40e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 62.55 E-value: 3.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQR------VAV-SLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSrdratgGCG 388
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRpsdvgeVRIrVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK------GTG 74
|
90 100
....*....|....*....|....*...
gi 490253565 389 LGLAIVHSIAQAMGGEVRCEASPLGGAR 416
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGAC 102
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
158-423 |
3.49e-12 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 67.41 E-value: 3.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 158 RPHWqdmlrIETAAQRFGEGHLseRIHFDSMSSFERLGVAFNQMADNINAliaskKQLIDGIAHELRTPLVRLRYRLEMS 237
Cdd:PRK11073 88 RSHI-----LSLTAQRLPEGMI--LLEMAPMDNQRRLSQEQLQHAQQVAA-----RDLVRGLAHEIKNPLGGLRGAAQLL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 238 EN------LTEAeSQALNRDIGQLEALIEELLTYARLDRPQTE------------LSLTTPDFPAWISDHvediqmvNPq 299
Cdd:PRK11073 156 SKalpdpaLTEY-TKVIIEQADRLRNLVDRLLGPQRPGTHVTEsihkvaervvqlVSLELPDNVRLIRDY-------DP- 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 300 revALATLTHgnygalDMRLMERVLDNLVNNALRYSSQ---------RVAVSLTLQGSR----ASLLVEDDGPGIAPEER 366
Cdd:PRK11073 227 ---SLPELAH------DPDQIEQVLLNIVRNALQALGPeggtitlrtRTAFQLTLHGERyrlaARIDIEDNGPGIPPHLQ 297
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 490253565 367 ERVFEPFVRldpSRDratGGCGLGLAIVHSIAQAMGGEVRCEASPlGGARFCFSWPV 423
Cdd:PRK11073 298 DTLFYPMVS---GRE---GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-414 |
7.02e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 61.71 E-value: 7.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 319 LMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLdPSRDRATGGCGLGLAIVHS 396
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL-PRPHSGQKSTGLGLAFVQE 82
|
90
....*....|....*...
gi 490253565 397 IAQAMGGEVRCEASPLGG 414
Cdd:cd16945 83 VAQLHGGRITLRNRPDGV 100
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-415 |
3.48e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.78 E-value: 3.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQRVAVSLTLQGSRASL--LVEDDGPGIAPEERERVFEPFVRLDPSRDrATGGCGLGLAI 393
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLyfEIWDNGHGFSEQDLKKALELFYRDDTSRR-SGGHYGMGLYI 79
|
90 100
....*....|....*....|..
gi 490253565 394 VHSIAQAMGGEVRCEASPLGGA 415
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGA 101
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
217-423 |
4.87e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 62.71 E-value: 4.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 217 DGIAHELrtplVRLRYRLEMSENLTEAESQALNRDIGQLEALIEELLTYAR----LDRPQTelsLTTPDFPAWISDHVED 292
Cdd:COG4585 63 DGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRrlvrGLRPPA---LDDLGLAAALEELAER 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 293 IQMVNPqreVALATLTHGNYGALDMRLME---RVLDNLVNNALRYS-SQRVAVSLTLQGSRASLLVEDDGPGIAPEerer 368
Cdd:COG4585 136 LLRAAG---IRVELDVDGDPDRLPPEVELalyRIVQEALTNALKHAgATRVTVTLEVDDGELTLTVRDDGVGFDPE---- 208
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 490253565 369 vfepfvrldpsrdrATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG4585 209 --------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
212-423 |
1.72e-10 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 63.04 E-value: 1.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 212 KKQLIDGIAHELRTPL---VRLRyRLEMSENLTEAESQALN-------------RDIGQLEalieelltyaRLDRPQTEL 275
Cdd:PRK11091 283 KTTFISTISHELRTPLngiVGLS-RILLDTELTAEQRKYLKtihvsaitlgnifNDIIDMD----------KMERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 276 SLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGNYGALDM----RLmERVLDNLVNNALRYSsQRVAVSLTL---QGS 348
Cdd:PRK11091 352 DNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHKVItdgtRL-RQILWNLISNAVKFT-QQGGVTVRVryeEGD 429
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490253565 349 RASLLVEDDGPGIAPEERERVFEPFVRLDPSRD--RATGgCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:PRK11091 430 MLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGgkPATG-TGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
218-428 |
2.15e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 62.77 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 218 GIAHELRTPLVRLRYRLEMSENlTEAESQALNRDIGQLEA-------LIEELLTYAR-LDRPQTELSLttpdfpawiSDH 289
Cdd:PRK13837 456 GIAHNFNNILGAILGYAEMALN-KLARHSRAARYIDEIISagararlIIDQILAFGRkGERNTKPFDL---------SEL 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 290 VEDIqmvnpqreVALATLTHGNYGALDMRL-------------MERVLDNLVNNALRYSSQRVAVSLTLQ---------- 346
Cdd:PRK13837 526 VTEI--------APLLRVSLPPGVELDFDQdqepavvegnpaeLQQVLMNLCSNAAQAMDGAGRVDISLSraklrapkvl 597
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 347 -------GSRASLLVEDDGPGIAPEERERVFEPFVRldpsrDRAtGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCF 419
Cdd:PRK13837 598 shgvlppGRYVLLRVSDTGAGIDEAVLPHIFEPFFT-----TRA-GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDV 671
|
....*....
gi 490253565 420 SWPVYHQLP 428
Cdd:PRK13837 672 YLPPSSKVP 680
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
317-422 |
9.43e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 60.63 E-value: 9.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 317 MRLmERVLDNLVNNALRYSSQ-RVAVSLTLQGS---RASLLVE--DDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLG 390
Cdd:PRK11107 407 LRL-QQIITNLVGNAIKFTESgNIDILVELRALsntKVQLEVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLG 485
|
90 100 110
....*....|....*....|....*....|..
gi 490253565 391 LAIVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:PRK11107 486 LVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
317-425 |
1.50e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 59.99 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 317 MRLmERVLDNLVNNALRYS-SQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRATGGCGLGLAIVH 395
Cdd:PRK10841 561 MRL-QQVISNLLSNAIKFTdTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICE 639
|
90 100 110
....*....|....*....|....*....|
gi 490253565 396 SIAQAMGGEVRCEASPLGGARFCFSWPVYH 425
Cdd:PRK10841 640 KLINMMDGDISVDSEPGMGSQFTIRIPLYG 669
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-422 |
1.72e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.98 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 316 DMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRdRATGGCGLGLAI 393
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQggKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 490253565 394 VHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
219-424 |
2.03e-09 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 59.11 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 219 IAHELRTPLVRLRYRLE-MSENLTEAESQ------ALNrDIGQLEALIEELLTYARldrPQTElSLTTPDfpawISDHVE 291
Cdd:COG5806 208 IAHEVRNPLTVVRGFIQlLQEPELSDEKRkqyiriALE-ELDRAEAIITDYLTFAK---PQPE-KLEKID----VSEELE 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 292 D-IQMVNP---QREVALATLTHGNYGAL-DMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRASLLVEDDGPGIAPE 364
Cdd:COG5806 279 HvIDVLSPyanMNNVEIQTELEPGLYIEgDRQKLQQCLINIIKNGIEAMPNggTLTIDVSIDKNKVIISIKDTGVGMTKE 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 365 ERERVFEPFVRLDpsrdraTGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPVY 424
Cdd:COG5806 359 QLERLGEPYFSTK------EKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
214-423 |
3.58e-09 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 58.59 E-value: 3.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 214 QLIDGIAHELRTPLVRLRYRLE-MSENLTEAES--QALNRDIGQLEALIEELLTYARLDRPQTE-----------LSLTT 279
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKGFLQlLQPGIEDKEEyfDIMLSELDRIESIISEFLALAKPQAVNKEkenineliqdvVTLLE 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 280 PDfpA------WISDHVEDIQMVNpqrevalatlthgnygaLDMRLMERVLDNLVNNALRY--SSQRVAVSLTLQGSRAS 351
Cdd:COG5805 369 TE--AilhniqIRLELLDEDPFIY-----------------CDENQIKQVFINLIKNAIEAmpNGGTITIHTEEEDNSVI 429
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490253565 352 LLVEDDGPGIaPEER-ERVFEPFVRLDPSrdratgGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPV 423
Cdd:COG5805 430 IRVIDEGIGI-PEERlKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-422 |
3.95e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 53.33 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 322 RVLDNLVNNALRYSS-QRVAVSLTLQGSRASLLVEDDGPGIAPEERErvfepfvrldpsrdratGGCGLGLAIVHSIAQA 400
Cdd:cd16917 3 RIVQEALTNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAEL 65
|
90 100
....*....|....*....|..
gi 490253565 401 MGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16917 66 LGGTLTIGSRPGGGTRVTARLP 87
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
214-424 |
7.12e-09 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 57.68 E-value: 7.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 214 QLIDGIAHELRTPLVRLRYRLE-MSENLTEAESQALN---RDIGQLEALIEELLTyarLDRPQtELSLTTPDfpawISDH 289
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKGFIQlLKDTIDEEQKTYLDimlSELDRIESIISEFLV---LAKPQ-AIKYEPKD----LNTL 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 290 VED-IQMVNPQrevalATLTH-----GNYGALDMRLME-----RVLDNLVNNALRY--SSQRVAVSLTLQ-GSRASLLVE 355
Cdd:COG5809 344 IEEvIPLLQPQ-----ALLKNvqielELEDDIPDILGDenqlkQVFINLLKNAIEAmpEGGNITIETKAEdDDKVVISVT 418
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490253565 356 DDGPGIaPEER-ERVFEPFvrldpsrdrAT---GGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPVY 424
Cdd:COG5809 419 DEGCGI-PEERlKKLGEPF---------YTtkeKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
320-422 |
8.62e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 53.15 E-value: 8.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 320 MERVLDNLVNNA-----------LRYSSQRVAVSLTLQ------GSRASLLVEDDGPGIAPEERERVFEPFVRLDPsrdr 382
Cdd:cd16919 1 LELAILNLAVNArdampeggrltIETSNQRVDADYALNyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE---- 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 490253565 383 ATGGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWP 422
Cdd:cd16919 77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
211-269 |
4.32e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 49.52 E-value: 4.32e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490253565 211 SKKQLIDGIAHELRTPLVRLRYRLEMSENLTEAESQA-----LNRDIGQLEALIEELLTYARLD 269
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQReyletILRSAERLLRLINDLLDLSRIE 64
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
327-423 |
9.79e-08 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 54.14 E-value: 9.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 327 LVNNALRYSSQR------VAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFVRLDPSRDRatgGCGLGLAIVHSIAQA 400
Cdd:TIGR02938 395 LVDNAIEAMNIKgwkrreLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK---HIGMGLSVAQEIVAD 471
|
90 100
....*....|....*....|...
gi 490253565 401 MGGEVRCEASPLGGARFCFSWPV 423
Cdd:TIGR02938 472 HGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
211-269 |
1.13e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 48.33 E-value: 1.13e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490253565 211 SKKQLIDGIAHELRTPLVRLRYRLEM--SENLTEAESQALN---RDIGQLEALIEELLTYARLD 269
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELllDTELSEEQREYLEtilREAERLLRLINDLLDLSRIE 64
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
207-415 |
4.69e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.00 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 207 ALIASKKQLIDGIAHELRTPLVRLRYRLEMSENLTEAESQALNRD-IGQLEALIE-------ELLTYAR-LDRPQTELSL 277
Cdd:COG4192 428 AKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTsLDKIEGLIErmdkiikSLRQFSRkSDTPLQPVDL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 278 TTPDFPAW----ISDHVEDIQMVNPQREVALAtlthgnygalDMRLMERVLDNLVNNALRYSSQ--RVAVSLTLQGSRAS 351
Cdd:COG4192 508 RQVIEQAWelveSRAKPQQITLHIPDDLMVQG----------DQVLLEQVLVNLLVNALDAVATqpQISVDLLSNAENLR 577
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490253565 352 LLVEDDGPGIApeERERVFEPFVrldpsrDRATGGCGLGLAIVHSIAQAMGGEVRCeASPL-GGA 415
Cdd:COG4192 578 VAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYL-ASTLeRGA 633
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
1-423 |
4.71e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 51.94 E-value: 4.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 1 MKKLFVQFYLLLFVCFLVMTMLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPRDWSKTLKELDLNLSFDLHIE 80
Cdd:COG2972 21 VLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 81 PISKFKLSESSMQHLRAGDIVALDDQYTFIQRIPRSHYVLSVGPVPYLYF-LHEMRLLDVALMAFIAISLAFPVFIWMRP 159
Cdd:COG2972 101 LLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRgLFSLRRLILLIILLLLLLALLLSYLLSRS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 160 HWQDMLRIETAAQRFGEGHLSeRIHFDSMSSFERLGVAFNQMADNINALIASKKQLidgiahELRtpLVRLRYR-LEMSE 238
Cdd:COG2972 181 ITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYEL------ELE--KKEAELKaLQAQI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 239 N-------LTEAESQALNRDIGQLEALIEELLTYAR--LDRPQTELSLTtpdfpawisdhvEDIQMVnpQREVALATLTH 309
Cdd:COG2972 252 NphflfntLNSIRWLAELEDPEEAEEMLEALSKLLRysLSKGDELVTLE------------EELELI--KSYLEIQKLRF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 310 GN---------YGALDMRLMERVLDNLVNNALRYS------SQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEPFV 374
Cdd:COG2972 318 GDrleveieidEELLDLLIPKLILQPLVENAIEHGiepkegGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELS 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 490253565 375 RLDPSRdratggcGLGLAIVHSIAQAMGGE---VRCEASPLGGARFCFSWPV 423
Cdd:COG2972 398 SKGEGR-------GIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
209-267 |
5.93e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 46.44 E-value: 5.93e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490253565 209 IASKKQLIDGIAHELRTPLVRLRYRLEMSENLTEAES------QALNRDIGQLEALIEELLTYAR 267
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEeqreylERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
323-413 |
1.18e-06 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 46.49 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 323 VLDNLVNNALRY-----SSQRVAVSLTLQGSRASLLVEDDGPGiapeerervFEPFVRLDPSRDRATGGcgLGLAIVHSI 397
Cdd:cd16936 4 AVSEAVTNAVRHayrhdGPGPVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREGG--RGLALIRAL 72
|
90
....*....|....*.
gi 490253565 398 AQamggEVRCEASPLG 413
Cdd:cd16936 73 MD----EVGYRRTPGG 84
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
327-402 |
1.58e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.22 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 327 LVNNALRY-----SSQRVAVSLTLQGSRASLLVEDDGPGIAPEERErvfepfvrlDPSRDRATGgcGLGLAIVHSIAQAM 401
Cdd:COG2172 42 AVTNAVRHayggdPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEG--GRGLFLIRRLMDEV 110
|
.
gi 490253565 402 G 402
Cdd:COG2172 111 E 111
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
166-205 |
2.36e-06 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 43.97 E-value: 2.36e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 490253565 166 RIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNI 205
Cdd:cd06225 6 RLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
323-411 |
2.50e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.53 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 323 VLDNLVNNALRYSSQ----RVAVSLTLQGSRASLLVEDDGPGIAPEERERVFEpfvrldpsRDRATGGC--GLGLAIVHS 396
Cdd:PRK11086 437 ILGNLIENALEAVGGeeggEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD--------KGYSTKGSnrGVGLYLVKQ 508
|
90
....*....|....*
gi 490253565 397 IAQAMGGEVRCEASP 411
Cdd:PRK11086 509 SVENLGGSIAVESEP 523
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
347-426 |
2.94e-06 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 49.28 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 347 GSRASLLVEDDGPGIAPEERERVFEPFVrldPSRDRATgGCGLGLAIVHSIAQAMGGEVRCEASPLGGARFCFSWPVYHQ 426
Cdd:PRK13557 322 GRYVSIAVTDTGSGMPPEILARVMDPFF---TTKEEGK-GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQ 397
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
164-210 |
4.86e-06 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 43.39 E-value: 4.86e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 490253565 164 MLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIA 210
Cdd:smart00304 7 LRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
327-423 |
2.49e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 46.44 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 327 LVNNALRY---SSQ--RVAVSLTLQGSRASLLVEDDGPGIAPEerervfepfvrLDPSRDRatggcGLGLAIVHSIAQAM 401
Cdd:COG3920 407 LVTNALKHaflSGEggRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQL 470
|
90 100
....*....|....*....|..
gi 490253565 402 GGEVRCEASPlgGARFCFSWPV 423
Cdd:COG3920 471 GGTLELDRPE--GTRVRITFPL 490
|
|
| HAMP |
pfam00672 |
HAMP domain; |
157-207 |
4.92e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 40.69 E-value: 4.92e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 490253565 157 MRPHWQDMLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINA 207
Cdd:pfam00672 3 ARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
93-371 |
7.94e-05 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 44.87 E-value: 7.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 93 QHLRAGDIVALDDQYTFIQRIPRSHYVLSVGPVPYLYFLHEMRLLDVALMAFIAISLAFPVFIWMRPHWQDMLRIETAAQ 172
Cdd:COG3850 75 LALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAE 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 173 RFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSENLTEAESQALNRDI 252
Cdd:COG3850 155 RIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAAL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 253 GQLEALIEELLTYARLDRPQTELSLTTPDFPAWISDHVEDIQMVNPQREVALATLTHGNYGALDMRLMERVLDNLVNNAL 332
Cdd:COG3850 235 LAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAAL 314
|
250 260 270
....*....|....*....|....*....|....*....
gi 490253565 333 RYSSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERVFE 371
Cdd:COG3850 315 LLLLLLQAIANASLLLIALASVVAALLELASILALQAAL 353
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
131-262 |
1.15e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 44.24 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 131 LHEMRLLDVALMAFIAISLAFPVFIwMRPHWQDMLRIETAAQRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIA 210
Cdd:COG0840 178 ALALALLAAALLALVALAIILALLL-SRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVG 256
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 490253565 211 SKKQLIDGI---AHELRtplvrlryrlEMSENLTE-AESQAlnRDIGQLEALIEEL 262
Cdd:COG0840 257 QVRESAEQVasaSEELA----------ASAEELAAgAEEQA--ASLEETAAAMEEL 300
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
17-277 |
1.18e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 41.25 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 17 LVMTMLVGLVYKFTAERAGRQSLDDLMKSSLYLMRSELREIPPRDWSKTLKELDLNLSFDLHIEPISKFKLSESSMQHLR 96
Cdd:COG2770 92 LALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 97 AGDIVALDDQYTFIQRIPRSHYVLSVGPVPYLYFLHEMRLLDVALMAFIAISLAFPVFIWM-----RPhwqdMLRIETAA 171
Cdd:COG2770 172 ELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLarritRP----LRRLAEAA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 172 QRFGEGHLSERIHFDSMSSFERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSENLTEAESQALNRD 251
Cdd:COG2770 248 RRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAA 327
|
250 260
....*....|....*....|....*.
gi 490253565 252 IGQLEALIEELLTYARLDRPQTELSL 277
Cdd:COG2770 328 LLLELLLLLLLALLLLLLLAADLLLA 353
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
314-398 |
2.09e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.04 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253565 314 ALDMRLmerVLDNLVNNALRY-----SSQRVAVSLTLQGSRASLLVEDDGPGIAPEERERvfepfvRLDPSRDRATGGCG 388
Cdd:pfam13581 29 LDEVEL---AVGEACTNAVEHayregPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP------PDLEEPDEDRKEGG 99
|
90
....*....|
gi 490253565 389 LGLAIVHSIA 398
Cdd:pfam13581 100 RGLALIRGLM 109
|
|
| |
