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Conserved domains on  [gi|490253909|ref|WP_004151902|]
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MULTISPECIES: cytosine permease [Klebsiella]

Protein Classification

purine-cytosine permease family protein( domain architecture ID 10003700)

purine-cytosine permease family protein is part of a family of transporters of purine- and pyrimidine-derivatives such as adenine, guanine, cytosine, and vitamin B6

Gene Ontology:  GO:0055085|GO:0016020
TCDB:  2.A.39

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CodB COG1457
Purine-cytosine permease or related protein [Nucleotide transport and metabolism];
3-452 2.48e-95

Purine-cytosine permease or related protein [Nucleotide transport and metabolism];


:

Pssm-ID: 441066 [Multi-domain]  Cd Length: 448  Bit Score: 294.47  E-value: 2.48e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909   3 ERRSIDYIPESERHGHPFSQFTLWFGGNLQITAIVTGALaVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQM 82
Cdd:COG1457   15 EDYGLEPVPESERHGSPRSLFWVWFGANVALATFVIGAL-LGLGLGFWQALLAILLGNLIGFLLGALIAYIGARTGLPTM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  83 ILSRAQFGVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNISH---VAGMLIFSAIIIVIAVLGYKVIHKLGKLASI 159
Cdd:COG1457   94 LLSRAAFGYRGSTLPSLLNALTTIGWFAVEAAIAAQALAALLGGLGiplVLAYLIVGLLVILLAIFGYRAISRLQRWAVP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 160 VGILAFVYMFI-TLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQIAFCPYVSDYSRYLPRDVSATKTWCSVFFGTVLGT 238
Cdd:COG1457  174 LLLVLFVLLVVlALSHPGLSALLAYPPGSSPLSFGAAVSVVAGLFISWAPYAADYSRYLPRKTSGRAVFWATFLGFVLGG 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 239 QTSMTLGVLTAAIAGSAfpGHEVSYLVGLGkSQAMAMVIYFAICFGKITFTTLNAYGSFMSLTTIVSAFRrqtvlsqkcR 318
Cdd:COG1457  254 VLLMLLGALLAAAAPGA--ADPVGALGALL-PTGLGVPALLVVILSQWTINVLNLYSASLALSNLFPRLG---------R 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 319 IAFVVLMVTASCIIALLsepAFLKHFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQQRYGFWNLYAITLYI 398
Cdd:COG1457  322 VVATLVVGVIGTLLALL---GFLDAFENFLLLLGVVLPPWGGIMLADYFLVRRGRYDPDALFDRRGRYGGVNWVGLIAWL 398
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490253909 399 VGVLIQLPFIENPLFHGSltwifAGNDVSWIIGWFGTGVLYYALRRFDRRSLPA 452
Cdd:COG1457  399 LGSVVGILFVNTPGLFGP-----ALADLSWLVALVVAAVLYLLLARYYLARPEA 447
 
Name Accession Description Interval E-value
CodB COG1457
Purine-cytosine permease or related protein [Nucleotide transport and metabolism];
3-452 2.48e-95

Purine-cytosine permease or related protein [Nucleotide transport and metabolism];


Pssm-ID: 441066 [Multi-domain]  Cd Length: 448  Bit Score: 294.47  E-value: 2.48e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909   3 ERRSIDYIPESERHGHPFSQFTLWFGGNLQITAIVTGALaVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQM 82
Cdd:COG1457   15 EDYGLEPVPESERHGSPRSLFWVWFGANVALATFVIGAL-LGLGLGFWQALLAILLGNLIGFLLGALIAYIGARTGLPTM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  83 ILSRAQFGVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNISH---VAGMLIFSAIIIVIAVLGYKVIHKLGKLASI 159
Cdd:COG1457   94 LLSRAAFGYRGSTLPSLLNALTTIGWFAVEAAIAAQALAALLGGLGiplVLAYLIVGLLVILLAIFGYRAISRLQRWAVP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 160 VGILAFVYMFI-TLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQIAFCPYVSDYSRYLPRDVSATKTWCSVFFGTVLGT 238
Cdd:COG1457  174 LLLVLFVLLVVlALSHPGLSALLAYPPGSSPLSFGAAVSVVAGLFISWAPYAADYSRYLPRKTSGRAVFWATFLGFVLGG 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 239 QTSMTLGVLTAAIAGSAfpGHEVSYLVGLGkSQAMAMVIYFAICFGKITFTTLNAYGSFMSLTTIVSAFRrqtvlsqkcR 318
Cdd:COG1457  254 VLLMLLGALLAAAAPGA--ADPVGALGALL-PTGLGVPALLVVILSQWTINVLNLYSASLALSNLFPRLG---------R 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 319 IAFVVLMVTASCIIALLsepAFLKHFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQQRYGFWNLYAITLYI 398
Cdd:COG1457  322 VVATLVVGVIGTLLALL---GFLDAFENFLLLLGVVLPPWGGIMLADYFLVRRGRYDPDALFDRRGRYGGVNWVGLIAWL 398
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490253909 399 VGVLIQLPFIENPLFHGSltwifAGNDVSWIIGWFGTGVLYYALRRFDRRSLPA 452
Cdd:COG1457  399 LGSVVGILFVNTPGLFGP-----ALADLSWLVALVVAAVLYLLLARYYLARPEA 447
SLC-NCS1sbd_CobB-like cd11484
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 ...
11-448 1.50e-90

nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271377 [Multi-domain]  Cd Length: 406  Bit Score: 281.04  E-value: 1.50e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  11 PESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVvWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQFG 90
Cdd:cd11484    1 VPEERRKSFLSMFSVWLGANFFLASMVTGALLGVGLSLS-QAILAVLLGNLIGGAYMALLGYIGARTGLPQMLLSRASFG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  91 VFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNISHV--AGMLIFSAIIIVIAVLGYKVIHKLGKLASIVGILAFVYM 168
Cdd:cd11484   80 EKGSYLPSLLLGITQIGWFGVGTAMFAIALSKLLGINGSlwLLILIAGVLMTLTAIFGYKALHKLEKIAVPLIIALFVYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 169 FITLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQIAFCPYVSDYSRYLprdVSATKTWCSVFFGTVLGTQTSMTLGVLT 248
Cdd:cd11484  160 VVLALRDYGVGGLAALTATGPLSFLVAVSLVAGSFISGATYTADYSRYA---KSSKKAFWATFLGFFVGNSLMMILGALL 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 249 AAIAGSAfpgHEVSYLVGLGksqaMAMVIYFAICFGKITFTTLNAYGSFMSLTTIVSAFRRQTVlsqkcriafVVLMVTA 328
Cdd:cd11484  237 AAATGTA---DISEVMIAQG----LGIPAILVLVLNIWTTNDNNLYSSGLSLSNITKIFRRKVL---------TLVAGIV 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 329 SCIIALLSepaFLKHFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQqrYGFWNLYAITLYIVGVLIQLPFI 408
Cdd:cd11484  301 GTLLAALG---IYNHFLNFLLLLGYALPPWGGVMLADYFVVRRGRYDIDALADPQ--YGGVNWAALIAWAVGVAVGIPFP 375
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 490253909 409 enplfhgslTWIFAGNDVSWIIGWFGTGVLYYALRRFDRR 448
Cdd:cd11484  376 ---------YGLLGGGGIAPINGLLVAAVVYYILRKILSK 406
Transp_cyt_pur pfam02133
Permease for cytosine/purines, uracil, thiamine, allantoin;
9-431 1.01e-36

Permease for cytosine/purines, uracil, thiamine, allantoin;


Pssm-ID: 251109  Cd Length: 439  Bit Score: 139.83  E-value: 1.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909    9 YIPESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQ 88
Cdd:pfam02133   1 PVPEEERTWSTRNLFSFWLGANFNINTWVIGALGVALGLNWWQSVLAIIAGNLIGAIFVALLGRAGAKYGLPFPILSRAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909   89 FGVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNI-------------SHVAGML---IFSAIIIVIAVLGYKVIHK 152
Cdd:pfam02133  81 FGIRGSLLPSLLRAVIACGWFGIQAWIGSEALLLMLGKifghwlwigaipgTGLTELVtffIFWLVHLYIVWLGVSAIRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  153 LGKLASIVGILAFVYMFITLLLSADLSALAHNNHFSLPTFLLAVSLsSSWQIAFCPYV---SDYSRYLPRDVSATKtwcs 229
Cdd:pfam02133 161 FFVIAAPLIPVAAFGFLIWAAVKAGGGPVFDQPVSPGKSELFLSAV-AGCAAGWATLIanaPDFTRYAPTARSSSK---- 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  230 VFFGTVLGTQTSMTL-GVLTAAIAGSAF--PGHEVSYLVGLGKSQAMAMVIYFAICFGKITFTTLNAYGSFMS-LTTIVS 305
Cdd:pfam02133 236 IQLVAVPGGFTLFALiGILGAAAAYAAYgaPAWDPLDILARFDPTAGVFLPAILVALAQLGTNISANLYSAGSdLAALLP 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  306 AFrrqtvLSQKCRIAFVVLMVTASCIIALLSEPAFLkhFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQQ- 384
Cdd:pfam02133 316 KK-----INRKRGSLIAAIIALVICPWKLLGNSAFM--FTTFLSLLSGFLSPVAGVIIADYFVVRRGYLHVAHLYTRRRg 388
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 490253909  385 -RYGF---WNLYAITLYIVGVLIQLPFIENPLFHGSLTWIFAGNDVSWIIG 431
Cdd:pfam02133 389 sAYWYrggVNWRAFAAYIVGIAAGLPGFSGSVGIKVPPGAMLGFDLSYLVG 439
PRK11375 PRK11375
putative allantoin permease;
11-449 1.17e-03

putative allantoin permease;


Pssm-ID: 183106  Cd Length: 484  Bit Score: 41.30  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  11 PESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQFG 90
Cdd:PRK11375  21 TQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRASYG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  91 VFGAVVPLVL----VCVMYIGF-----SASGTVLAGQAMAKLLNI--------SHVAGM---LIFSAIIIVIAVLGYKVI 150
Cdd:PRK11375 101 VRGALFPGLLrggiAAIMWFGLqcyagSLALLILIGKIWPGFLTLggdftllgLSLPGLitfLIFWLVNVGIGFGGGKVL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 151 HK----LGKLASIV----GILAFVYMFITLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQiAFCPYVSDYsrylprdvs 222
Cdd:PRK11375 181 NKftaiLNPCIYIVfggmAIWAISLVGIGPIFDYIPSGIQKAENSGFLFLVVINAVVAVWA-APAVSASDF--------- 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 223 aTKTWCSvFFGTVLGTQTSMTLGVLTAAIA-------GSAFPGHEVSYLVGLGKSQAMAMVIYFAICFGKITFTTLNAYG 295
Cdd:PRK11375 251 -TQNAHS-FRAQALGQTLGLVVAYILFAVAsvciiagASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATG 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 296 SfmslttIVSAFRRQTVLSQKcRIAFVVLMVTASCIIALLSEPAFLKH---FTHFLLFLLAFFVPWSAICLTDYYLISKG 372
Cdd:PRK11375 329 N------IIPAGYQIAALAPT-KLTYKNGVLIASIISLLICPWKLMENqdsIYLFLDIIGGMLGPVIGVMMAHYFVVMRG 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 373 AIDIPALSDPQQRYGFW----NLYAITLYIVGVLIQL-----PFIEnPLfhgsltwifagNDVSWIIGWFGTGVLYYALR 443
Cdd:PRK11375 402 QINLDELYTAPGDYKYYdngfNLTAFSVTLVAVILSLggkfiPFME-PL-----------SRVSWFVGVIVAFVAYALLK 469

                 ....*.
gi 490253909 444 RFDRRS 449
Cdd:PRK11375 470 KRTTAE 475
 
Name Accession Description Interval E-value
CodB COG1457
Purine-cytosine permease or related protein [Nucleotide transport and metabolism];
3-452 2.48e-95

Purine-cytosine permease or related protein [Nucleotide transport and metabolism];


Pssm-ID: 441066 [Multi-domain]  Cd Length: 448  Bit Score: 294.47  E-value: 2.48e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909   3 ERRSIDYIPESERHGHPFSQFTLWFGGNLQITAIVTGALaVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQM 82
Cdd:COG1457   15 EDYGLEPVPESERHGSPRSLFWVWFGANVALATFVIGAL-LGLGLGFWQALLAILLGNLIGFLLGALIAYIGARTGLPTM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  83 ILSRAQFGVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNISH---VAGMLIFSAIIIVIAVLGYKVIHKLGKLASI 159
Cdd:COG1457   94 LLSRAAFGYRGSTLPSLLNALTTIGWFAVEAAIAAQALAALLGGLGiplVLAYLIVGLLVILLAIFGYRAISRLQRWAVP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 160 VGILAFVYMFI-TLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQIAFCPYVSDYSRYLPRDVSATKTWCSVFFGTVLGT 238
Cdd:COG1457  174 LLLVLFVLLVVlALSHPGLSALLAYPPGSSPLSFGAAVSVVAGLFISWAPYAADYSRYLPRKTSGRAVFWATFLGFVLGG 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 239 QTSMTLGVLTAAIAGSAfpGHEVSYLVGLGkSQAMAMVIYFAICFGKITFTTLNAYGSFMSLTTIVSAFRrqtvlsqkcR 318
Cdd:COG1457  254 VLLMLLGALLAAAAPGA--ADPVGALGALL-PTGLGVPALLVVILSQWTINVLNLYSASLALSNLFPRLG---------R 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 319 IAFVVLMVTASCIIALLsepAFLKHFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQQRYGFWNLYAITLYI 398
Cdd:COG1457  322 VVATLVVGVIGTLLALL---GFLDAFENFLLLLGVVLPPWGGIMLADYFLVRRGRYDPDALFDRRGRYGGVNWVGLIAWL 398
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490253909 399 VGVLIQLPFIENPLFHGSltwifAGNDVSWIIGWFGTGVLYYALRRFDRRSLPA 452
Cdd:COG1457  399 LGSVVGILFVNTPGLFGP-----ALADLSWLVALVVAAVLYLLLARYYLARPEA 447
SLC-NCS1sbd_CobB-like cd11484
nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 ...
11-448 1.50e-90

nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271377 [Multi-domain]  Cd Length: 406  Bit Score: 281.04  E-value: 1.50e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  11 PESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVvWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQFG 90
Cdd:cd11484    1 VPEERRKSFLSMFSVWLGANFFLASMVTGALLGVGLSLS-QAILAVLLGNLIGGAYMALLGYIGARTGLPQMLLSRASFG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  91 VFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNISHV--AGMLIFSAIIIVIAVLGYKVIHKLGKLASIVGILAFVYM 168
Cdd:cd11484   80 EKGSYLPSLLLGITQIGWFGVGTAMFAIALSKLLGINGSlwLLILIAGVLMTLTAIFGYKALHKLEKIAVPLIIALFVYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 169 FITLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQIAFCPYVSDYSRYLprdVSATKTWCSVFFGTVLGTQTSMTLGVLT 248
Cdd:cd11484  160 VVLALRDYGVGGLAALTATGPLSFLVAVSLVAGSFISGATYTADYSRYA---KSSKKAFWATFLGFFVGNSLMMILGALL 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 249 AAIAGSAfpgHEVSYLVGLGksqaMAMVIYFAICFGKITFTTLNAYGSFMSLTTIVSAFRRQTVlsqkcriafVVLMVTA 328
Cdd:cd11484  237 AAATGTA---DISEVMIAQG----LGIPAILVLVLNIWTTNDNNLYSSGLSLSNITKIFRRKVL---------TLVAGIV 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 329 SCIIALLSepaFLKHFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQqrYGFWNLYAITLYIVGVLIQLPFI 408
Cdd:cd11484  301 GTLLAALG---IYNHFLNFLLLLGYALPPWGGVMLADYFVVRRGRYDIDALADPQ--YGGVNWAALIAWAVGVAVGIPFP 375
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 490253909 409 enplfhgslTWIFAGNDVSWIIGWFGTGVLYYALRRFDRR 448
Cdd:cd11484  376 ---------YGLLGGGGIAPINGLLVAAVVYYILRKILSK 406
Transp_cyt_pur pfam02133
Permease for cytosine/purines, uracil, thiamine, allantoin;
9-431 1.01e-36

Permease for cytosine/purines, uracil, thiamine, allantoin;


Pssm-ID: 251109  Cd Length: 439  Bit Score: 139.83  E-value: 1.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909    9 YIPESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQ 88
Cdd:pfam02133   1 PVPEEERTWSTRNLFSFWLGANFNINTWVIGALGVALGLNWWQSVLAIIAGNLIGAIFVALLGRAGAKYGLPFPILSRAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909   89 FGVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNI-------------SHVAGML---IFSAIIIVIAVLGYKVIHK 152
Cdd:pfam02133  81 FGIRGSLLPSLLRAVIACGWFGIQAWIGSEALLLMLGKifghwlwigaipgTGLTELVtffIFWLVHLYIVWLGVSAIRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  153 LGKLASIVGILAFVYMFITLLLSADLSALAHNNHFSLPTFLLAVSLsSSWQIAFCPYV---SDYSRYLPRDVSATKtwcs 229
Cdd:pfam02133 161 FFVIAAPLIPVAAFGFLIWAAVKAGGGPVFDQPVSPGKSELFLSAV-AGCAAGWATLIanaPDFTRYAPTARSSSK---- 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  230 VFFGTVLGTQTSMTL-GVLTAAIAGSAF--PGHEVSYLVGLGKSQAMAMVIYFAICFGKITFTTLNAYGSFMS-LTTIVS 305
Cdd:pfam02133 236 IQLVAVPGGFTLFALiGILGAAAAYAAYgaPAWDPLDILARFDPTAGVFLPAILVALAQLGTNISANLYSAGSdLAALLP 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  306 AFrrqtvLSQKCRIAFVVLMVTASCIIALLSEPAFLkhFTHFLLFLLAFFVPWSAICLTDYYLISKGAIDIPALSDPQQ- 384
Cdd:pfam02133 316 KK-----INRKRGSLIAAIIALVICPWKLLGNSAFM--FTTFLSLLSGFLSPVAGVIIADYFVVRRGYLHVAHLYTRRRg 388
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 490253909  385 -RYGF---WNLYAITLYIVGVLIQLPFIENPLFHGSLTWIFAGNDVSWIIG 431
Cdd:pfam02133 389 sAYWYrggVNWRAFAAYIVGIAAGLPGFSGSVGIKVPPGAMLGFDLSYLVG 439
SLC-NCS1sbd cd10323
nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; NCS1s are essential ...
19-445 2.61e-24

nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. This family includes Microbacterium liquefaciens Mhp1, a transporter that mediates the uptake of indolyl methyl- and benzyl-hydantoins as part of a metabolic salvage pathway for their conversion to amino acids. It also includes various Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), vitamin B6 transporter Tpn1, nicotinamide riboside transporter 1 (Nrt1p, also called Thi71p), Dal4p (allantoin permease), Fui1p (uridine permease), and Fur4p (uracil permease). Mhp1 has 12 transmembrane (TM) helices (an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12; TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and SLC6 neurotransmitter transporters.


Pssm-ID: 271358  Cd Length: 414  Bit Score: 104.28  E-value: 2.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  19 PFSQFTLWFGGNLQITAIVTGAlAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQFGVFGAVVPL 98
Cdd:cd10323    4 PLSYLAMWLGDCVSIGTFTLGG-SLVGLGLLWQVILAILIGCLIIGIFLVLNGRIGYKYGIPFAVQLRASFGIKGSHIPS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  99 VLVCVMYIGFSASGTVLAGQAMAKLLNI-----SHVAGMLIFSAIIIVIAVLGYKVIHKLGKLASIVGILAFVYMFITLL 173
Cdd:cd10323   83 LLRGVPAIVWFGFQTWLGALALNEISGLlfgfdNIVLCFIIFGLLQIVLSFFGIKAIKWLENIAAPAIIAALVYMFYLLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 174 LSADLSALAHNNHFSL---PTFLLAVSLSSSWQIAFCPYVSDYSRYLPRDVSATKTWCSVFFGTVLGTQTSMTLGVLTAA 250
Cdd:cd10323  163 NKAGDEIGENLWYKAGtwgLPFLVAIMAFVGNWAALALNAPDYSRELKPGKRNRNVGLAQFVALVPAFLFMGLIGAMSTA 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 251 IAGSAFPgheVSYLVGLGKSQAMAMVIYFAICFGKITFTTLN----AYGSFMSLTTIVSAFRRQTVLsqkcriafVVLMV 326
Cdd:cd10323  243 ATGIWNP---VDVIQGVVSNGFLLVLTLVFIVLAQWSTNIAAnivpPAYVFMNLFPRKITYKTGVVI--------AGILG 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 327 TASCIIALLSEPAFLKHFTHFLLFLLAffvPWSAICLTDYYLISKGAIDIPALSDPQQRYGFW---NLYAITLYIVGVLI 403
Cdd:cd10323  312 LCICPWLLVNDLSALTTFLGIYSAFLG---PIFGIMIADYYVLRRRRVNVDDLYDANGQYKYFkgvNWAAIIAMAVGAAA 388
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 490253909 404 QLPFIenplfhgsltwifagnDVSWIIGWFGTGVLYYALRRF 445
Cdd:cd10323  389 ALLLV----------------DLSWFVGLIVAGLLYYPLMKR 414
SLC-NCS1sbd_NRT1-like cd11482
nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; This fungal ...
5-445 5.07e-16

nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; This fungal NCS1 subfamily includes various Saccharomyces cerevisiae transporters: nicotinamide riboside transporter 1 (Nrt1p, also called Thi71p), Dal4p (allantoin permease), Fui1p (uridine permease), Fur4p (uracil permease), and Thi7p (thiamine transporter). NCS1s are essential components of salvage pathways for nucleobases and related metabolites. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters, and solute carrier 6 family neurotransmitter transporters.


Pssm-ID: 271375  Cd Length: 480  Bit Score: 79.87  E-value: 5.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909   5 RSIDYIPESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMIL 84
Cdd:cd11482    4 RDLDPVPPERRTWGWWSFFAYWISDSFNISTWQTGSSLLALGLSWWQAIGAVIIGNILIAIFVVLNGRPGAKYHIGFPVA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  85 SRAQFGVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLN------------ISHVAGM--------LIFSAIIIVIAV 144
Cdd:cd11482   84 SRASFGIYGSYFPVIIRVVLAIVWFGVQAWTGGQCVTVMLRaifpsflnipntLPASAGIttaqligfFLFWLIQLPFLF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 145 LGYKVIHKLGKLASIVGILAFVYMFItlllsadlsALAHNNHFSLPTFLLAVSLSSS---WQI---------AFCPYV-- 210
Cdd:cd11482  164 IPPEKLRHLFTVKAVIVPIAALGLLI---------WALAKAGGAGPLVSQPSSLSGSalgWAWlsginsiigGFSTLIvn 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 211 -SDYSRYLPRDVSAtkTWCSVFFGTVLGTQTSMtLGVLTAAiAGSAFPGHEV--------SYLVGLGKSQAMAMVIYFAI 281
Cdd:cd11482  235 qPDFTRYAKKPPDA--VWGQLISIPLSGTLVPL-LGILTTS-ASKVLYGEAYwnpldlldAWLDHDYSAGARAAAFFAAL 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 282 CFGKITFTT---LNAYGSFMSLTTIVSAF---RRQTVLSQKcrIAFVV----LMVTASCIIALLSEPA-FLKhfthfllf 350
Cdd:cd11482  311 GFALAQLGTnisANSISAGNDLTGLFPKYiniRRGAIICAI--LGWAIvpwkLLNSASSFLTFLSSYSvFLA-------- 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 351 llaffvPWSAICLTDYYLISKGAIDIPAL--SDPQQRYGFW---NLYAITLYIVGVLIQLP-FIE--NPLFHGSLTW--I 420
Cdd:cd11482  381 ------PIAGIMIADYYIVRRGKLKLPDLytASPHGIYWYTkgvNWRAFVAWLVGVAPNLPgLANsvNPPVSVPGGAvrL 454
                        490       500
                 ....*....|....*....|....*
gi 490253909 421 FAGNdvsWIIGWFGTGVLYYALRRF 445
Cdd:cd11482  455 YYLG---YLLGFLISFVVYYVLCLI 476
SLC-NCS1sbd_YbbW-like cd11485
uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; ...
10-445 1.33e-12

uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. This subfamily includes the putative allantoin transporter Escherichia coli YbbW (also known as GlxB2). NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271378  Cd Length: 456  Bit Score: 69.52  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  10 IPESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQF 89
Cdd:cd11485   12 VPPEQRTWTTWNYAALWIGMVHNIPTYMLASGLIALGMSWWQALLTVVLGNLIVLIPMVLNGHAGTKYGIPFPVLARASF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  90 GVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNISHV------------AGMLIFSAIIIVIAVLGYKVIHKLGKLA 157
Cdd:cd11485   92 GVRGANIPALLRAIVACGWFGIQTWIGGQAIYAILGVLIWpgwlgigfgqlfCFLLFPWALNVWIIYKGMESIRKLEAWA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 158 SIVGILAFVYMFITLLLSA--------DLSALAHNNHFSLPTFLLAVSLSSSWQIAFCPYVSDYSRYlprdvsaTKTWCS 229
Cdd:cd11485  172 APLLILLSLALLIWAISKAggfgpilsQPSAFGPKGGNFWKVFFPALTAMIGFWATLALNIPDFTRF-------AKSQRA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 230 VFFGTVLGTQTSMTL----GVLTAAIAGSAF--PGHEVSYLVGLGKSQAMAMVIYFAICFGkiTFTTlNAYGSFMSLTTI 303
Cdd:cd11485  245 QVLGQAIGLPITMALfafvGVAVTSATVVIFgeAIWDPVDLLSRFDNPAVVIIALLAIILA--TLST-NVAANLVSPAYD 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 304 VSA-------FRRQTVLSqkcriafvvlmvtasCIIALLSEPAFLKHFTHFLLFLLAFFV-----PWSAICLTDYYLISK 371
Cdd:cd11485  322 FANlfpkkisFRRGGLIT---------------AVLGLLIMPWKLLENADGYIFTWLGGYgallgPIAGIMIADYWLVRR 386
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490253909 372 GAIDIPALSDPQQRYGF---WNLYAITLYIVGVLIQLPfienPLFHGSLTWIFagnDVSWIIGWFGTGVLYYALRRF 445
Cdd:cd11485  387 TRLDLDDLYRRGGRYWYsngWNWRALIALAVGVLPALP----GFLIPALKWLY---DYAWFVGFAVAGLLYLLLMKR 456
FUI1 COG1953
Cytosine/uracil/thiamine/allantoin permease [Nucleotide transport and metabolism, Coenzyme ...
10-448 1.16e-11

Cytosine/uracil/thiamine/allantoin permease [Nucleotide transport and metabolism, Coenzyme transport and metabolism];


Pssm-ID: 441556  Cd Length: 483  Bit Score: 66.37  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  10 IPESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQF 89
Cdd:COG1953   28 TPAEKRTWGWYNIFALWMGMVHSVPGYTLAAGLFALGLSWWQALLALLLGNLIVLVPMNLNGHAGTKYGIPFPVLARASF 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  90 GVFGAVVPLVLVCVMYIGFSASGTVLAGQAMAKLLNIS----------------HVAGMLIFSAIIIVIAVLGYKVIHKL 153
Cdd:COG1953  108 GVRGANIPALLRGLIAIGWFGIQTYLASQALDALLLKLfpglaslggahsflglSALGWISFLLFWALQLLIFWRGMEAI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 154 GKLASIVGILAFVYMFITLLLSADLSALAhNNHFSLPT-----------FLLAVSLSSSWQIAFCPYVSDYSRYlprdvs 222
Cdd:COG1953  188 RKFEDWAGPLVYVVMLALAIWALSKAGGF-GPILSLPSkflsggafwavFFPALTLMVAYWATLALNFPDFTRF------ 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 223 aTKTWCSVFFGTVLGTQTSMTL-GVLTAAIAGSAFP--GH---EVSYLVGLGKSQAMAMVIYFAICFGkiTFTTlNAYGS 296
Cdd:COG1953  261 -AKSQRAQVRGQFLGLPVNMLLfSFIGVVTTSATVVvfGEaiwDPVELVARIDSPFAVVLALLTFLIA--TVGI-NIVAN 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 297 FMSLTTIVSA-------FRRQTVLSqkCRIAFVV----LMVTASCIIALLSE-PAFLKhfthfllfllaffvPWSAICLT 364
Cdd:COG1953  337 FVSPAYDFSNlfpkkisFRRGGLIT--AVIGLLItpwnLYNSPEGIFYFLGGlGALLG--------------PVFGILIA 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 365 DYYLISKGAIDIPAL-SDPQQRYGF---WNLYAITLYIVGVLIQLPfienPLFHGSLTWIFagnDVSWIIGWFGTGVLYY 440
Cdd:COG1953  401 DYYLVRRQRLDVDDLySEDDGRYWYrngWNPRAVIALVVGAVISLA----GALVPALAPLY---DYSWFVGAALGGVLYL 473

                 ....*...
gi 490253909 441 ALRRFDRR 448
Cdd:COG1953  474 ALMRRRPR 481
SLC-NCS1sbd_Mhp1-like cd11483
nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; This NCS1 ...
13-171 1.21e-06

nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; This NCS1 subfamily includes Microbacterium liquefaciens Mhp1, and various uncharacterized NCS1s. Mhp1 mediates the uptake of indolyl methyl- and benzyl-hydantoins as part of a metabolic salvage pathway for their conversion to amino acids. Mhp1 has 12 transmembrane (TM) helices (an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12; TMs numbered to conform to the Solute carrier 6 (SLC6) family Aquifex aeolicus LeuT). NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their other known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and SLC6 neurotransmitter transporters.


Pssm-ID: 271376  Cd Length: 451  Bit Score: 50.51  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  13 SERHGHPFSQFTLWFGGNLQITAIVTGA-LAVVLGGDVVWSLV-GLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQFG 90
Cdd:cd11483   16 AERSMSLFDYAILWAGMTINVVAFSLGAqYYNGGDGLSPWTVIvVILIGYGIVTILTFLTGDIGTKYGVPFAVYARAPFG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  91 VFGAVVPLVLVCVM---YIGFSA-SGTVLAGQAMAKLLNISHVAGMLI-FSAIIIVIAVLGYKVIHKLGKLASIVGILAF 165
Cdd:cd11483   96 YKGSLIAGLLRAIPslyWFGFQTwVGALALNEIMRILFGFSNLTLMIIiFAAIQVVNTMYGLKAMAKFDWIAIPVLAIMF 175

                 ....*.
gi 490253909 166 VYMFIT 171
Cdd:cd11483  176 VAIVYL 181
SLC-NCS1sbd_u1 cd11555
uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding ...
357-444 3.14e-06

uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).


Pssm-ID: 271404  Cd Length: 461  Bit Score: 49.48  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 357 PWSAICLTDYYLISKGAIDIPAL--SDPQQRYGF---WNLYAITLYIVGVLIQLPFIENPLFHGsltwiFAGndVSWIIG 431
Cdd:cd11555  375 PLFGILIVDYYLVRKGRVDVPDLysDSPKGAYWYrngWNPKAVAALVPAAAISVLTVLVPALAA-----LAG--FSWFIG 447
                         90
                 ....*....|...
gi 490253909 432 WFGTGVLYYALRR 444
Cdd:cd11555  448 AALGGVLYYLLAR 460
PRK11375 PRK11375
putative allantoin permease;
11-449 1.17e-03

putative allantoin permease;


Pssm-ID: 183106  Cd Length: 484  Bit Score: 41.30  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  11 PESERHGHPFSQFTLWFGGNLQITAIVTGALAVVLGGDVVWSLVGLLVGQMLGAAVMSLHALQGPRLGLPQMILSRAQFG 90
Cdd:PRK11375  21 TQSQRTWKTFNYFTLWMGSVHNVPNYVMVGGFFILGLSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMILRASYG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909  91 VFGAVVPLVL----VCVMYIGF-----SASGTVLAGQAMAKLLNI--------SHVAGM---LIFSAIIIVIAVLGYKVI 150
Cdd:PRK11375 101 VRGALFPGLLrggiAAIMWFGLqcyagSLALLILIGKIWPGFLTLggdftllgLSLPGLitfLIFWLVNVGIGFGGGKVL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 151 HK----LGKLASIV----GILAFVYMFITLLLSADLSALAHNNHFSLPTFLLAVSLSSSWQiAFCPYVSDYsrylprdvs 222
Cdd:PRK11375 181 NKftaiLNPCIYIVfggmAIWAISLVGIGPIFDYIPSGIQKAENSGFLFLVVINAVVAVWA-APAVSASDF--------- 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 223 aTKTWCSvFFGTVLGTQTSMTLGVLTAAIA-------GSAFPGHEVSYLVGLGKSQAMAMVIYFAICFGKITFTTLNAYG 295
Cdd:PRK11375 251 -TQNAHS-FRAQALGQTLGLVVAYILFAVAsvciiagASIHYGADTWNVLDIVQRWDSLFASFFAVLVILMTTISTNATG 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 296 SfmslttIVSAFRRQTVLSQKcRIAFVVLMVTASCIIALLSEPAFLKH---FTHFLLFLLAFFVPWSAICLTDYYLISKG 372
Cdd:PRK11375 329 N------IIPAGYQIAALAPT-KLTYKNGVLIASIISLLICPWKLMENqdsIYLFLDIIGGMLGPVIGVMMAHYFVVMRG 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490253909 373 AIDIPALSDPQQRYGFW----NLYAITLYIVGVLIQL-----PFIEnPLfhgsltwifagNDVSWIIGWFGTGVLYYALR 443
Cdd:PRK11375 402 QINLDELYTAPGDYKYYdngfNLTAFSVTLVAVILSLggkfiPFME-PL-----------SRVSWFVGVIVAFVAYALLK 469

                 ....*.
gi 490253909 444 RFDRRS 449
Cdd:PRK11375 470 KRTTAE 475
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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