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Conserved domains on  [gi|490254476|ref|WP_004152455|]
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BRO family protein [Klebsiella pneumoniae]

Protein Classification

Bro-N domain-containing protein( domain architecture ID 11466490)

Bro-N domain-containing protein may bind DNA to influence host DNA replication and/or transcription; may function as an antirepressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
4-113 1.03e-44

Prophage antirepressor [Mobilome: prophages, transposons];


:

Pssm-ID: 442835  Cd Length: 106  Bit Score: 145.04  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476   4 QTAPTVFSFESTvNIRMVMIDQRPYFVAQDVCSALEIQSVDVALRKVDSDEKGTYSIRTPGGYQSLSVVNESGLYWLMLR 83
Cdd:COG3617    2 NNLITVFNFEGH-EVRTVEIDGEPWFVAKDVARALGYSNPSDALKHLDDDEKTKLELDTPGGPQEMLFISESGLYRLILR 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 490254476  84 CRKAAvegtsAYRFRKWVTSEVLPQIRKTG 113
Cdd:COG3617   81 SRKPE-----AKRFKRWVTDEVLPSIRKTG 105
 
Name Accession Description Interval E-value
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
4-113 1.03e-44

Prophage antirepressor [Mobilome: prophages, transposons];


Pssm-ID: 442835  Cd Length: 106  Bit Score: 145.04  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476   4 QTAPTVFSFESTvNIRMVMIDQRPYFVAQDVCSALEIQSVDVALRKVDSDEKGTYSIRTPGGYQSLSVVNESGLYWLMLR 83
Cdd:COG3617    2 NNLITVFNFEGH-EVRTVEIDGEPWFVAKDVARALGYSNPSDALKHLDDDEKTKLELDTPGGPQEMLFISESGLYRLILR 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 490254476  84 CRKAAvegtsAYRFRKWVTSEVLPQIRKTG 113
Cdd:COG3617   81 SRKPE-----AKRFKRWVTDEVLPSIRKTG 105
Bro-N smart01040
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 17-107 3.01e-30

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 214989  Cd Length: 89  Bit Score: 107.66  E-value: 3.01e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476    17 NIRMVMIDQRPYFVAQDVCSALEIQSVDVALRKVDSDEK---GTYSIRTPGGYQSLSVVNESGLYWLMLRCRKAAvegts 93
Cdd:smart01040   1 KVRTVLIDGEPWFVAKDVARALGYSNPRDAIRKLDDDEKrvaGTELLDTLGGKQEVRIISESGLYRLIMRSRKPE----- 75

                           90
                   ....*....|....
gi 490254476    94 AYRFRKWVTSEVLP 107
Cdd:smart01040  76 AKKFRRWVTDEVLP 89
Bro-N pfam02498
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 17-107 1.17e-18

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteriztic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 376797  Cd Length: 96  Bit Score: 77.78  E-value: 1.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476   17 NIR-MVMIDQRPYFVAQDVCSALEIQSVDVAL-RKVDSDEKGTYSIR--------TPGGYQSLSVVNESGLYWLMLRCRK 86
Cdd:pfam02498   1 EIRtVVDENGEPWFVAKDVAKALGYTNPNKAIkKHVDKANKKCLNELvntldhedGKNGHPKTVFINEAGLYLLIMRSDK 80

                          90       100
                  ....*....|....*....|.
gi 490254476   87 AAVEgtsayRFRKWVTSEVLP 107
Cdd:pfam02498  81 PKAE-----EFRKWVTQEVLP 96
 
Name Accession Description Interval E-value
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
4-113 1.03e-44

Prophage antirepressor [Mobilome: prophages, transposons];


Pssm-ID: 442835  Cd Length: 106  Bit Score: 145.04  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476   4 QTAPTVFSFESTvNIRMVMIDQRPYFVAQDVCSALEIQSVDVALRKVDSDEKGTYSIRTPGGYQSLSVVNESGLYWLMLR 83
Cdd:COG3617    2 NNLITVFNFEGH-EVRTVEIDGEPWFVAKDVARALGYSNPSDALKHLDDDEKTKLELDTPGGPQEMLFISESGLYRLILR 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 490254476  84 CRKAAvegtsAYRFRKWVTSEVLPQIRKTG 113
Cdd:COG3617   81 SRKPE-----AKRFKRWVTDEVLPSIRKTG 105
Bro-N smart01040
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 17-107 3.01e-30

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 214989  Cd Length: 89  Bit Score: 107.66  E-value: 3.01e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476    17 NIRMVMIDQRPYFVAQDVCSALEIQSVDVALRKVDSDEK---GTYSIRTPGGYQSLSVVNESGLYWLMLRCRKAAvegts 93
Cdd:smart01040   1 KVRTVLIDGEPWFVAKDVARALGYSNPRDAIRKLDDDEKrvaGTELLDTLGGKQEVRIISESGLYRLIMRSRKPE----- 75

                           90
                   ....*....|....
gi 490254476    94 AYRFRKWVTSEVLP 107
Cdd:smart01040  76 AKKFRRWVTDEVLP 89
Bro-N pfam02498
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 17-107 1.17e-18

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteriztic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 376797  Cd Length: 96  Bit Score: 77.78  E-value: 1.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490254476   17 NIR-MVMIDQRPYFVAQDVCSALEIQSVDVAL-RKVDSDEKGTYSIR--------TPGGYQSLSVVNESGLYWLMLRCRK 86
Cdd:pfam02498   1 EIRtVVDENGEPWFVAKDVAKALGYTNPNKAIkKHVDKANKKCLNELvntldhedGKNGHPKTVFINEAGLYLLIMRSDK 80

                          90       100
                  ....*....|....*....|.
gi 490254476   87 AAVEgtsayRFRKWVTSEVLP 107
Cdd:pfam02498  81 PKAE-----EFRKWVTQEVLP 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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