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Conserved domains on  [gi|490261070|ref|WP_004158290|]
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NADP-dependent phosphogluconate dehydrogenase [Erwinia amylovora]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-466 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 957.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   2 SKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENP-GKKLVPHYTIEEFVSSLEKPRRILLMVQAGEAT 80
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  81 DKTIASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIA 160
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 161 AVAEGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTK 240
Cdd:COG0362  161 AKVDGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 241 KDEE-GHYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVE 319
Cdd:COG0362  241 KDPEtGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFIE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 320 KVRRALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADE 399
Cdd:COG0362  321 DLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKK 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261070 400 YQQALRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEW 466
Cdd:COG0362  401 AQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-466 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 957.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   2 SKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENP-GKKLVPHYTIEEFVSSLEKPRRILLMVQAGEAT 80
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  81 DKTIASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIA 160
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 161 AVAEGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTK 240
Cdd:COG0362  161 AKVDGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 241 KDEE-GHYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVE 319
Cdd:COG0362  241 KDPEtGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFIE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 320 KVRRALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADE 399
Cdd:COG0362  321 DLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKK 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261070 400 YQQALRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEW 466
Cdd:COG0362  401 AQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
14-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 931.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  14 MGRNLALNIESRGYSVSIFNRSREKTDEVVAE-NPGKKLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKTIASLTPHLD 92
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  93 KGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAA-VAEGEACVAY 171
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAkVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 172 MGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDEE-GHYLVD 250
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEEtGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 251 VILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVqAVSADKAEFVEKVRRALYLGKI 330
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAA-KFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 331 VSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEYQQALRDVVAY 410
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490261070 411 AVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEWLD 468
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSE 457
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 5-468 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 833.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070    5 QIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAE-NPGKKLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKT 83
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   84 IASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAAVA 163
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  164 EGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDE 243
Cdd:TIGR00873 161 DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKDE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  244 EGHYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVEKVRR 323
Cdd:TIGR00873 241 DGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVRQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  324 ALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEYQQA 403
Cdd:TIGR00873 321 ALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQSG 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261070  404 LRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDG--VFHTEWLD 468
Cdd:TIGR00873 401 WRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 178-466 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 567.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  178 GHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDEE-GHYLVDVILDEA 256
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  257 ANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVEKVRRALYLGKIVSYAQG 336
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  337 FSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEYQQALRDVVAYAVQNGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 490261070  417 PTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEW 466
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-466 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 957.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   2 SKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENP-GKKLVPHYTIEEFVSSLEKPRRILLMVQAGEAT 80
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGkGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  81 DKTIASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIA 160
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 161 AVAEGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTK 240
Cdd:COG0362  161 AKVDGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 241 KDEE-GHYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVE 319
Cdd:COG0362  241 KDPEtGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFIE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 320 KVRRALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADE 399
Cdd:COG0362  321 DLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKK 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261070 400 YQQALRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEW 466
Cdd:COG0362  401 AQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
14-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 931.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  14 MGRNLALNIESRGYSVSIFNRSREKTDEVVAE-NPGKKLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKTIASLTPHLD 92
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  93 KGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAA-VAEGEACVAY 171
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAkVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 172 MGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDEE-GHYLVD 250
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEEtGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 251 VILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVqAVSADKAEFVEKVRRALYLGKI 330
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAA-KFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 331 VSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEYQQALRDVVAY 410
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490261070 411 AVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEWLD 468
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEWSE 457
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 5-468 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 833.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070    5 QIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAE-NPGKKLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKT 83
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEeAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   84 IASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAAVA 163
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  164 EGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDE 243
Cdd:TIGR00873 161 DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKDE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  244 EGHYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVEKVRR 323
Cdd:TIGR00873 241 DGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVRQ 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  324 ALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEYQQA 403
Cdd:TIGR00873 321 ALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQSG 400

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261070  404 LRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDG--VFHTEWLD 468
Cdd:TIGR00873 401 WRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTG 467
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 1-468 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 634.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   1 MSKQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVV--AENPGK-KLVPHYTIEEFVSSLEKPRRILLMVQAG 77
Cdd:PLN02350   4 AALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVerAKKEGNlPLYGFKDPEDFVLSIQKPRSVIILVKAG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  78 EATDKTIASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILT 157
Cdd:PLN02350  84 APVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 158 EIAAVAEGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDI 237
Cdd:PLN02350 164 KVAAQVDDGPCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITADI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 238 FTKKDEEGH-YLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAV-----S 311
Cdd:PLN02350 244 FSVKDDKGDgYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAGLEDIlsadsG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 312 ADKAEFVEKVRRALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAP 391
Cdd:PLN02350 324 VDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVDP 403

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261070 392 YFKNIADEYQQALRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEWLD 468
Cdd:PLN02350 404 EFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSFHTEWTK 480
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 6-466 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 630.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   6 IGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVV--AENPGKKLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKT 83
Cdd:PTZ00142   4 IGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVkkAKEGNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAVDET 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  84 IASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAAVA 163
Cdd:PTZ00142  84 IDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSAKV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 164 EGEACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDE 243
Cdd:PTZ00142 164 GDSPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILAKKDD 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 244 EGH-YLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPK--VQAVSADKAEFVEK 320
Cdd:PTZ00142 244 LGEeHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNpaNKTETEDKKYFIDD 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 321 VRRALYLGKIVSYAQGFSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEY 400
Cdd:PTZ00142 324 LKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDELKNK 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490261070 401 QQALRDVVAYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEW 466
Cdd:PTZ00142 404 QPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 178-466 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 567.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  178 GHYVKMVHNGIEYGDMQLIAEAYSLLKGALNLSNEELAETFSKWNEGELSSYLIDITKDIFTKKDEE-GHYLVDVILDEA 256
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  257 ANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAASKVLSGPKVQAVSADKAEFVEKVRRALYLGKIVSYAQG 336
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  337 FSQLKAASTENNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYEDNADIANLLLAPYFKNIADEYQQALRDVVAYAVQNGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 490261070  417 PTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKDGVFHTEW 466
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
5-289 2.61e-95

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 289.73  E-value: 2.61e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   5 QIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENpgkkLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKTI 84
Cdd:PRK09599   2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDATI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  85 ASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAAVAE 164
Cdd:PRK09599  78 DELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 165 GEacVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLK-GALNLSNEELAETfskWNEGE-LSSYLIDITKDIFtKKD 242
Cdd:PRK09599 158 DG--YLHAGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEaSRFDLDLAAVAEV---WRRGSvIRSWLLDLTADAL-AED 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 490261070 243 EEghylVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLS 289
Cdd:PRK09599 232 PK----LDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAALFMRFRS 274
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
5-289 7.10e-95

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 288.53  E-value: 7.10e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   5 QIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENpgkkLVPHYTIEEFVSSLEKPRRILLMVQAGEATDKTI 84
Cdd:COG1023    2 QIGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAALAAEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  85 ASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAAVAE 164
Cdd:COG1023   78 EELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070 165 GeaCVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGA-LNLSNEELAETfskWNEGE-LSSYLIDITKDIFtKKD 242
Cdd:COG1023  158 N--GYLHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEASeFDLDLAEVAEV---WRRGSvIRSWLLDLTADAL-AED 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490261070 243 EEghylvdviLDE----AANKGTGKWTSQSSLDLGEPLSLITESVFARYLS 289
Cdd:COG1023  232 PK--------LEGisgyVEDSGEGRWTVEEAIELGVPAPVITAALFARFRS 274
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 5-173 2.63e-65

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 207.32  E-value: 2.63e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070    5 QIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENpgkkLVPHYTIEEFVSSLekpRRILLMVQAGEATDKTI 84
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAG----AIAAASPAEFVAGL---DVVITMVPAGAAVDAVI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   85 --ASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPILTEIAa 161
Cdd:pfam03446  74 fgEGLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG- 152

                         170
                  ....*....|..
gi 490261070  162 vaegeACVAYMG 173
Cdd:pfam03446 153 -----ACVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 5-303 8.14e-60

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 198.15  E-value: 8.14e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070    5 QIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENPGKKLvphyTIEEFVSSLEKPRRILLMVQAGeATDKTI 84
Cdd:TIGR00872   2 QLGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKAMKEDRTTGVA----NLRELSQRLSAPRVVWVMVPHG-IVDAVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   85 ASLTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTEIAAVAE 164
Cdd:TIGR00872  77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEEQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  165 GeacVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGA-LNLSNEELAETfskWNEGE-LSSYLIDITKDIFTKKD 242
Cdd:TIGR00872 157 G---YLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVARV---WRRGSvIRSWLLDLTAIAFRESP 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490261070  243 EeghylVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSslKTQRVAASKVLS 303
Cdd:TIGR00872 231 D-----LAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFAS--RDLDDFANKVLA 284
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 3-221 2.80e-27

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 110.59  E-value: 2.80e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   3 KQQIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAEnpGKKLVPhyTIEEFVSSLEkprRILLMVQAGEATDK 82
Cdd:COG2084    1 MMKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAA--GARVAA--SPAEAAAAAD---VVITMLPDDAAVEE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  83 TIAS---LTPHLDKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPILte 158
Cdd:COG2084   74 VLLGedgLLAALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVL-- 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490261070 159 iAAVAEGeacVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKgALNLSNEELAETFSKW 221
Cdd:COG2084  152 -EAMGKR---IVHVGDAGAGQAAKLANNLLLAGTMAALAEALALAE-KAGLDPETLLEVLSGG 209
garR PRK11559
tartronate semialdehyde reductase; Provisional
 4-202 8.65e-13

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 68.92  E-value: 8.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   4 QQIGVVGMAVMGRNLALNIESRGYSVSIFNRSREKTDEVVAENPgkklvphytieEFVSSLEkprrillmvQAGEATDKT 83
Cdd:PRK11559   3 MKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGA-----------ETASTAK---------AVAEQCDVI 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  84 IASL--TPHLD--------------KGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGP-SIMPGGQK 146
Cdd:PRK11559  63 ITMLpnSPHVKevalgengiiegakPGTVVIDMSSIAPLASREIAAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDK 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490261070 147 EAYELVAPILTEIAavaegeACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEAYSL 202
Cdd:PRK11559 143 AIFDKYYDLMKAMA------GSVVHTGDIGAGNVTKLANQVIVALNIAAMSEALVL 192
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
5-199 6.04e-06

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 48.09  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070   5 QIGVVGMAVMGRNLALNIESRGYSVSIfnrsreKTDEVVAENPGKKLVPHYTIEEFVSslEKPRRILLMVQAGEATDKTI 84
Cdd:PRK15059   2 KLGFIGLGIMGTPMAINLARAGHQLHV------TTIGPVADELLSLGAVSVETARQVT--EASDIIFIMVPDTPQVEEVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261070  85 --------ASLtphldKGDILIDGGNTFYKDTIRRNRELSEQGFNFIGTGVSGGEEGALKGP-SIMPGGQKEAYELVAPI 155
Cdd:PRK15059  74 fgengctkASL-----KGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPL 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 490261070 156 LTEIAavaegeACVAYMGPDGAGHYVKMVHNGIEYGDMQLIAEA 199
Cdd:PRK15059 149 FELLG------KNITLVGGNGDGQTCKVANQIIVALNIEAVSEA 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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