|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-396 |
0e+00 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 610.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 20 MLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIE 99
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 100 QLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTL 179
Cdd:PRK11102 81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 180 LVVTQIKETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNI 259
Cdd:PRK11102 161 LVFFFIPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 260 VFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILEEFPHMA 339
Cdd:PRK11102 241 VFLFVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLGFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490261258 340 GTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLYASRPLQT 396
Cdd:PRK11102 321 GTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYLYASRPKKK 377
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
7-391 |
3.23e-121 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 356.31 E-value: 3.23e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 7 SPAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFA 86
Cdd:TIGR00710 2 SAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 87 ITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAI 166
Cdd:TIGR00710 82 LSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 167 FWIISAVAVITTLLVVTQIKETLPKEKRQkfSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHI 246
Cdd:TIGR00710 162 FAFLSLAGILLSALIFFILPETLPYEARI--QISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 247 SPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIGC-VSMVSS 325
Cdd:TIGR00710 240 SPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIgNSMISS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490261258 326 NAMAVILEEFPHMAGTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLYAS 391
Cdd:TIGR00710 320 IAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-390 |
1.64e-101 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 306.04 E-value: 1.64e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 12 VVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAA 91
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 92 CAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIIS 171
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 172 AVAVITTLLVVTQIKETLPKEKRqKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNF 251
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKR-KPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 252 GYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALN-LGFLPLVFGVAMFIGCVSMVSSNAMAV 330
Cdd:cd17320 240 GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGgLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 331 ILEEFPHMAGTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLYA 390
Cdd:cd17320 320 ALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-357 |
1.21e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 155.13 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 1 MAMEKNSPAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAI 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 81 GTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLL 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 161 WSWHAIFWIISAVAVITTLLVVTQIKETLPKEKRQKfslratLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVY 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 241 IELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSalnlGFLPLVFGVAMFIGCV 320
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|....*...
gi 490261258 321 SMVSSNAMAVILEEFP-HMAGTASSLAGTLRFGVGGLA 357
Cdd:COG2814 311 GLLFPLLQALVAELAPpEARGRASGLYNSAFFLGGPLA 348
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
3-392 |
4.68e-41 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 149.29 E-value: 4.68e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 3 MEKNSPAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGT 82
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 83 LIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWS 162
Cdd:PRK11652 81 SIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 163 WHAIFWIISAVAVITTLLVVTQIKETLPKEKRQkfslRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIE 242
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPETRPADARR----TRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 243 LNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGfLPLVFGVAMFIGCVSM 322
Cdd:PRK11652 237 VLGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPGWFGVMNV-WTLLVPAALFFFGAGM 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 323 VSSNAMAVILEEFPHMAGTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLYASR 392
Cdd:PRK11652 316 LFPLATSGAMEPFPYLAGTAGALLGGLQNIGSGLAALLSAMLPQTGQFSLGLLMTLMGLLILLCWLPLAT 385
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
10-385 |
1.32e-35 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 134.63 E-value: 1.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 10 GLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITA 89
Cdd:PRK11043 6 GFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 90 AACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIF-- 167
Cdd:PRK11043 86 LGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFat 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 168 -WIISAVAVITTLLVVTQIKETLPKEKRQkfslratlgNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHi 246
Cdd:PRK11043 166 lFAITLLLILPTLRLKPSKKARKQSQDAL---------TFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQMGY- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 247 SPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLgLLIQFSMGIWLVVVSAL--NLGFLPL--VFGV--AMFIGCV 320
Cdd:PRK11043 236 SPADIGLSYVPQTIAFLVGGYGCRAALQKWGGEQLLPW-LLVLFAVSVIAIWLASLlsHPSLVPLliPFCVmaAANGAIY 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490261258 321 SMVSSNAmaviLEEFPHMAGTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSIL 385
Cdd:PRK11043 315 PIVVAQA----LRPFPQATGKAAALQNTLQLGLCFLASLLVSALISTPLLTTGSVMLSTVVLVAL 375
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
17-388 |
3.84e-30 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 119.74 E-value: 3.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 17 LLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQ 96
Cdd:PRK10473 10 ALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 97 TIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVI 176
Cdd:PRK10473 90 TSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 177 TTLLVVTQIKETLPKEKRQKFSLRATLGNfllLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFA 256
Cdd:PRK10473 170 VLLLSLFILKETRPARAPAASSKPRENSE---SLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGEYAIIMA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 257 LNIVFLFLMTLLNSRCVRRFGP--VLMFRLGLLIQFSMGIWLVVVSALNLgflplvFGVAMFIGCVSMVSSNAMAVILEE 334
Cdd:PRK10473 247 LTAGVSMTVSFSTPFALGIFKPrtLMLTSQVLFLAAGITLALSPSHAVSL------FGITLICAGFSVGFGVAMSQALGP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490261258 335 FPHMAGTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFL 388
Cdd:PRK10473 321 FSLRAGVASSTLGIAQVCGSSLWIWLAAVLGISAWNMLIGILIACSIVSLLLIL 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-390 |
1.52e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 111.89 E-value: 1.52e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 12 VVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAA 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 92 CAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWvLLLWSWHAIFWIIS 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 172 AVAVITTLLVVTQIKETLPKEKRQKFSlraTLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNF 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSAT---KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 252 GYYFALNIVFLFLMTLLNSRCV-RRFGPVLMFRLGLLIqfsMGIWLVVVSALNLgfLPLVFGVAMFIG-CVSMVSSNAMA 329
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGLLL---YALSLLLLGFVPS--LALLLIAIVLFGlGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490261258 330 VILEEFP-HMAGTASSLAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLYA 390
Cdd:cd17474 312 LVTELAPeEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-364 |
5.35e-27 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 110.34 E-value: 5.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAV 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 95 AQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVA 174
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 175 VITTLLVvtqiketlpkekrqkfslratlgnflllfrhQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYY 254
Cdd:cd17321 161 LVALLLA-------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 255 FALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQfSMGIWLVVVSALNLGFLPLVFGVAMF-IGCVSMVSSNAMAVILE 333
Cdd:cd17321 210 LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT-AVGLLLLALLGADSSVWLLLPGLVLLgLGLGLFATPLTNAALSS 288
|
330 340 350
....*....|....*....|....*....|.
gi 490261258 334 EFPHMAGTASSLAGTLRFGVGGLAGALLSAL 364
Cdd:cd17321 289 VPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-390 |
7.72e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.97 E-value: 7.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAV 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 95 AQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVA 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 175 VITTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYY 254
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 255 FALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSalnlGFLPLVFGVAMFIGCVSMVSSNAMAVILEE 334
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 335 FPHMA-GTASSLAGTLrFGVGGLAGALLSAL---NFTSAWPMVVAMFICSTLSILLFLYA 390
Cdd:cd17325 317 VPPEGrGTAMGLFNTA-FSLGMVLGPLLGGFlydAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
31-388 |
9.66e-27 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 109.56 E-value: 9.66e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 31 PALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGL 110
Cdd:cd17324 20 GLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 111 SAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVTqikeTLP 190
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR----LLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 191 KEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNS 270
Cdd:cd17324 176 SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 271 RCVRRFGpvlMFRLGLLIQFSMGIWLVVVSALNLGFLpLVFGVAMFIGCVSMVSSNAMAVILEEFPHMAGTASSLAGTLr 350
Cdd:cd17324 256 RLADRGG---RRALLIALLLLAAALLLLTLLGPSPLL-LLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAA- 330
|
330 340 350
....*....|....*....|....*....|....*...
gi 490261258 351 FGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFL 388
Cdd:cd17324 331 YNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
15-252 |
4.89e-26 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 108.49 E-value: 4.89e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSI-----------DMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTL 83
Cdd:PRK15402 7 LGRQALLFPLCLvlfefatyianDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 84 IFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSW 163
Cdd:PRK15402 87 FFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPW 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 164 HAIFWIISAVAVITTLLVVTQIKETLpKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIEL 243
Cdd:PRK15402 167 RGMFVLFAALAALSFFGLWRAMPETA-GRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVILISG 245
|
....*....
gi 490261258 244 NHISPQNFG 252
Cdd:PRK15402 246 EQLSSYEYG 254
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-388 |
2.97e-25 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 105.74 E-value: 2.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 12 VVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAA 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 92 CAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIIS 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 172 AVAVITTLLVVtqiketlpkekrqkfslratlgnflllFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHIS---- 247
Cdd:cd17323 161 IISGFCLILIF---------------------------LFLPIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSpgev 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 248 -----PQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLM-FRLGLLIqfsMGIWLVVVSALNLGF--------LPLVFGV 313
Cdd:cd17323 214 glmylPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPeARLPPAF---IGAFLFPIGLFIFGWtiyphihwIVPIIGS 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261258 314 AMFIGCVSMVSSNAMAVILEEFPHMAGTASSLAGTLRFGVGGLAGALLSAL--NFTSAWPMVVAMFICSTLSILLFL 388
Cdd:cd17323 291 AFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMfnNLGVGWAFTLLAFISLAMIPIPFI 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-357 |
4.20e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.81 E-value: 4.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQ-IAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 94 VAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAV 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 174 AVITTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPfVYIELNHISPQNFGY 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 254 YFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILE 333
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....
gi 490261258 334 EFPHMAGTASSLAGTLRFGVGGLA 357
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALG 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-393 |
1.26e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.19 E-value: 1.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 12 VVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAA 91
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 92 CAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIIS 171
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 172 AVAVITTLLVVTQIKETLPKEKRQKfslRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNF 251
Cdd:COG2223 167 ILLLVVAVLAWLFLRDPPAGAAAAA---KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 252 GYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIqfsMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVI 331
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL---MALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490261258 332 LEEFP-HMAGTASSLAGTLrFGVGGLAGALLSAL------NFTSAWPMVVAMFICSTLSILLFLYASRP 393
Cdd:COG2223 321 PDIFPtKNAGAVYGLVGAA-GGLGGFLGPLLFGAlldatgSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-296 |
3.64e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 95.65 E-value: 3.64e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 2 AMEKNSPAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIG 81
Cdd:COG0477 6 AAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 82 TLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLW 161
Cdd:COG0477 86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 162 SWHAIFWIISAVAVITTLLVVtqikeTLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYI 241
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRL-----RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 490261258 242 ELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWL 296
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
53-188 |
9.91e-22 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 90.40 E-value: 9.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 53 VYILGFSLGQLIYGPLA----DSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYS 128
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 129 KEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVTQIKET 188
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-392 |
4.74e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.40 E-value: 4.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 11 LVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAA 90
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 91 ACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWII 170
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 171 SAVAVITTLLvvtqiketlpkekrqkfslratlgnflllfrhqRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQN 250
Cdd:COG2271 171 GLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 251 FGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFigCVSMVSSNAMAV 330
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF--GLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261258 331 ILEEFP-HMAGTASSLAGTLRFGVGGLA----GALLSALNFTSAWPMVVAMFICSTLSILLFLYASR 392
Cdd:COG2271 296 AAELFPkKARGTASGLVNTFGFLGGALGpllvGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-364 |
1.83e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 91.87 E-value: 1.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAV 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 95 AQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVA 174
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 175 VITTLLVVTqiketlpkekrqkFSLRatlgnfllLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYY 254
Cdd:cd17503 161 ILALLLAPL-------------LDLR--------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 255 FALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIqFSMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILEE 334
Cdd:cd17503 220 LAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL-LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNS 298
|
330 340 350
....*....|....*....|....*....|.
gi 490261258 335 FP-HMAGTASSLAGTLRFGVGGLAGALLSAL 364
Cdd:cd17503 299 LPpEQIGDATALFNTIRQLGGSIGTALLATL 329
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
24-253 |
9.76e-18 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 84.11 E-value: 9.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 24 LSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIY 103
Cdd:PRK15403 30 LTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 104 IRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVT 183
Cdd:PRK15403 110 ARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLL 189
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 184 QIKETLPKEKRQkFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGY 253
Cdd:PRK15403 190 AMPETVKRGAVP-FSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAW 258
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-336 |
4.22e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.85 E-value: 4.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 13 VILGLLAMLMPLSIDMYLPALPQIAREFS-VSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAA 91
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 92 CAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWvLLLWSWHAIFWIIs 171
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGA-LAEIGWRAPFLVY- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 172 AVAVITTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLfrhqRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNF 251
Cdd:cd17473 160 LLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWK----RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 252 GYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIqfsMGIWLVVVSALNlgFLPLVFGVAMFIGC-VSMVSSNAMAV 330
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL---MALGFLLLALAS--GLWVVLLGAILAGLgFGLLLPTLNSW 310
|
....*.
gi 490261258 331 ILEEFP 336
Cdd:cd17473 311 AMSLVP 316
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-392 |
4.22e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.21 E-value: 4.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 3 MEKNSPAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGT 82
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 83 LIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYsKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLL-- 160
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLgl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 161 -WSWHAIFWIISAVAVITTLLVVTQikeTLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFV 239
Cdd:COG0738 160 sLSWHLPYLILAVLLLLLALLFLRS---KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 240 YIELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIqfsmGIWLVVVSALNLGFLPLVFGVAMFIGC 319
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALL----AAVGLLLALLAPGPWLALIGLALVGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490261258 320 VSMVSSNAMAVILEEFPHMAGTASSLAGTLrFGVGGLAGALLSALnFTSAWPMVVAMFICSTLSILLFLYASR 392
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAVSAVLIM-GIVGGAIGPPLIGF-LADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-364 |
1.12e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAV 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 95 AQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVL--LLWSWHAIFWIISA 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 173 VAVITTLLVVTQIKET--LPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQN 250
Cdd:cd06174 161 LALLAAILLLLVVPDPpeSARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 251 FGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFrlgLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAV 330
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL---LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350
....*....|....*....|....*....|....*
gi 490261258 331 ILEEFP-HMAGTASSLAGTLRFGVGGLAGALLSAL 364
Cdd:cd06174 318 IAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-391 |
1.54e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.25 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 24 LSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIY 103
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 104 IRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVT 183
Cdd:cd17489 90 LRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 184 QIKETLPKEKRQKFSLRatlgnFLLLFRHQRVLSYMLASGFSFAGLFAFINsgpFVYIELNHISPQNFGYYFALNIVFLF 263
Cdd:cd17489 170 VKDPPPVAAEEAEAGTR-----AFRRLVEKKVLPPALILFLASIAYGAIST---FLPLYAAERGISNAGLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 264 LMTLLNSRCVRRFGPVLMFRLGLLIqfsMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILEEFPHMAGTAS 343
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLL---LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490261258 344 SL---AGTLRFGVGG-LAGALLSALNFTSAWPMVVamfICSTLSILLFLYAS 391
Cdd:cd17489 319 GTffiFFDLGIGLGGlLLGLVAELFGYRAMFLLAA---VVVLLALVLYIFLL 367
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
15-181 |
8.99e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.92 E-value: 8.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAV 94
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 95 AQTIEQLIYIRFLHGLSAAAGSVVIsALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVA 174
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFPLAF-ALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
....*..
gi 490261258 175 VITTLLV 181
Cdd:cd17504 160 VLLAALV 166
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-392 |
5.36e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 72.65 E-value: 5.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 28 MYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAI-----GTLIFAITAAACAVAQTIEQLI 102
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 103 YIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVV 182
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 183 TQIKETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSG-PFVYIELNHISPQNFGYYFALNIVF 261
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLlPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 262 LFLMTLLNSRCVRRFGPVLMFRLGLLIqfsMGIWLVVVSALNlgFLPLVFGVAMFIGCVSMVSSNAMAVILEEF--PHMA 339
Cdd:cd06173 257 ALLGALLLGRLSKRRRRGRLLLIGALL---LGLALLVLGLSP--SLWLLLAALFLLGLAGGLFNVPLNTLLQLRvpDELR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490261258 340 GTASSLAGTLRFGVGGLAGALLSALnfTSAWPMVVAMFICSTLSILLFLYASR 392
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLL--ADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-389 |
1.09e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.79 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 36 IAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAG 115
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 116 SVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLwSWHAIFWIISAVAVITTLLVVTQIKETLPKEKRQ 195
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 196 KfsLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRR 275
Cdd:cd17329 185 E--KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVER 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 276 FGPVLMFRLGLLIqfsMGIWLVVVSALNlGFLPLVFGVAMFIGCVSMVSSNAMAVILEEFP-HMAGT---ASSLAGTLRF 351
Cdd:cd17329 263 FRLRKILMIGILL---FAIGFAVLAFAN-TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPpDKRGSymgFYALAWGLGR 338
|
330 340 350
....*....|....*....|....*....|....*...
gi 490261258 352 GVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLY 389
Cdd:cd17329 339 AIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
32-194 |
1.59e-12 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 68.56 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 112 AAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVTQIKETLPK 191
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPA 183
|
...
gi 490261258 192 EKR 194
Cdd:TIGR00711 184 ASE 186
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
6-181 |
8.29e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 66.23 E-value: 8.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 6 NSPAGLVVILGLLAMLMP-LSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLI 84
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDgYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 85 FAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWH 164
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170
....*....|....*..
gi 490261258 165 AIFWIISAVAVITTLLV 181
Cdd:TIGR00895 172 SLFYVGGIAPLLLLLLL 188
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-389 |
9.28e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 65.70 E-value: 9.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 51 LNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGsvVISALMRDSYSKE 130
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 131 EFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVTqikeTLPKEKRQKFSLRATLGNFLLLF 210
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLF----FVPDPPKIVQISEKEKKKLKKLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 211 RHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIqF 290
Cdd:cd17472 192 KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILL-I 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 291 SMGIWLVVVSALNLGFlpLVFGVAMFigcvsMVSSNAMAVILEEF------PHMAGTASSLAGTLRF---GVGGLAGALL 361
Cdd:cd17472 271 AVGFLLLLFAATSLWL--LIIGLIIF-----FIGFNLLEALLPSLvskiapKEYRGTAMGIYNTSQFlgsFLGGALGGLL 343
|
330 340
....*....|....*....|....*...
gi 490261258 362 SALNFTSAWPMVVAMFICSTLSILLFLY 389
Cdd:cd17472 344 WGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-386 |
1.05e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 65.67 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 112 AAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVvtqiketlpk 191
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW---------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 192 ekrqkfslratlgnfllLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNSR 271
Cdd:cd17319 175 -----------------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 272 CVRRFGPvLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILEEFP-HMAGTASSLAGtlr 350
Cdd:cd17319 238 LSDRLLR-GARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLIN--- 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 490261258 351 fGVGGLAGALLSAL---------NFTSAWPMVVAMFICSTLSILL 386
Cdd:cd17319 314 -SGGNLGGFVAPLLigylvdatgSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
32-169 |
4.95e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 63.35 E-value: 4.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSvSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 490261258 112 AAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWI 169
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-364 |
1.23e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.39 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 112 AAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVA-PLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVTQIKET-- 188
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSpq 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 189 ---LPK-------------EKRQKFSLRATLGNFLLLFrhQRVLSYM-LASGFSFAGLFAFINSGPFVYIELNHISPQNF 251
Cdd:TIGR00881 177 scgLPPaeempneepdgdaEKKEEELTKKQIFLQYVLL--NKVLWYIsLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 252 GYYFALNIVFLFLMTLL-----NSRCVRRFGPVLMFRLGLLIqFSMGIWLVVVSALNLGFLPLVFGVAMFI-GCVSMVSS 325
Cdd:TIGR00881 255 SWAFTLYELGGLVGTLLagwlsDKLFNGRRGPLAVFFMALII-VSLLVYWLNPAANPLMDLICLFALGFLVyGPQMLIGV 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 490261258 326 NAMAVIleeFPHMAGTASSLAGTLRFGVGGLAGALLSAL 364
Cdd:TIGR00881 334 IASELA---PKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-393 |
5.95e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 60.27 E-value: 5.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 5 KNSPAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLI 84
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 85 FAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKeEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWH 164
Cdd:COG2807 93 LAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 165 AIFWIISAVAVITTLLVVTQIKETLPKEKRQKFSLRATlgnflLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELn 244
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR-----SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 245 HISPQNFGYYFAL----NIVFLFLMTLLNSRCVRRFGPVLmfrlglliqFSMGIWLVVVSALNLGFLPLVFGVAMFIG-C 319
Cdd:COG2807 246 GLSAATAGLLLSLfqlaGIPGSLLVPLLADRLGDRRPLLL---------LLGLLGLAGLLGLLLAPGSLPWLWAVLLGlG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 320 VSMVSSNAMAVILEEF--PHMAGTASSLAGTLRFGVGGLAGALLSAL-----NFTSAWpmvVAMFICSTLSILLFLYASR 392
Cdd:COG2807 317 QGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLLAALGPLLVGALhdatgSWTAAL---LLLAALAVLMLVAGLLAGR 393
|
.
gi 490261258 393 P 393
Cdd:COG2807 394 P 394
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-387 |
1.00e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.54 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQ--MTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHG 109
Cdd:cd17316 21 VAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 110 LSAAAGSVVISALMRDSYSKEE----FSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLvvtqi 185
Cdd:cd17316 101 IGIGGEYPGASTYVAEFAPSKRrgfaLGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 186 ketlpkekrqkfslratlgnflllfrHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLM 265
Cdd:cd17316 176 --------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 266 TLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVvsALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILEEFP-HMAGTASS 344
Cdd:cd17316 230 ALIAGLLSDRIGRKKTLVIGLILSGILALPLFY--LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVG 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490261258 345 LA---GTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLF 387
Cdd:cd17316 308 LSynlGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
74-364 |
2.52e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.76 E-value: 2.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 74 RKPVIAIGTL---IFAITAAACAVAQTIEQLIY---IRFLHGLSAAAGSVVISALMRD-SYSKEEFSRMMSFVLLVMTVA 146
Cdd:COG2211 80 RRPWILIGAIplaLSFVLLFTAPDLSPTGKLIYalvTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 147 PLVAPILGGWVLLLWS------WHAIFWIISAVAVITTLLVVTQIKETlPKEKRQKFSLRATLGnflLLFRHQRVLSYML 220
Cdd:COG2211 160 GLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKER-PVPEEEKVSLKESLK---ALLKNRPFLLLLL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 221 ASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVS 300
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG 315
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 301 ALNLG-FLPLVFGVAMFIGCVSMVSSNAMAVILEE-----FPHMAGTASSLAGTLRFGVGGLAGALLSAL 364
Cdd:COG2211 316 PGNLWlLLVLAALAGIGLGAILVLPWAMLADVVDYdewktGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
31-388 |
3.80e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.67 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 31 PALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGL 110
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 111 SAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVtqiketlp 190
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF-------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 191 kekrqkfslratlgnFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNS 270
Cdd:cd17312 176 ---------------FFLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 271 RCVRRF-----GPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGvaMFIGCVSMVSSNAMAVILeeFPHMA-GTASS 344
Cdd:cd17312 241 LLSDKLfggrrAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIG--FFVGGPINLIGGAAAQDI--GRKEAaGTATG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490261258 345 LAGTLRFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFL 388
Cdd:cd17312 317 FVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
12-185 |
4.16e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.60 E-value: 4.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 12 VVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAA 91
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 92 CAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIIS 171
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170
....*....|....
gi 490261258 172 AVAVITTLLVVTQI 185
Cdd:cd17365 161 VPPLILLPLLRGTL 174
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-187 |
9.70e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.86 E-value: 9.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 26 IDMYLPA--LPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIY 103
Cdd:cd17328 13 MDRFTIAgvLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 104 IRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLW-SWHAIFWIISAVAVITTLLVV 182
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLL 172
|
....*
gi 490261258 183 TQIKE 187
Cdd:cd17328 173 LFVRE 177
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-388 |
1.07e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.54 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 28 MYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFL 107
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 108 HGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLL----WSWHAIFWiISAVAVITTLLVVT 183
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFL-LGALPALLVLFIRR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 184 QIKET-LPKEKRQKFSLRATLGNFLLLFRHQRV---LSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNI 259
Cdd:cd17371 176 FVKEPpQWQAARAARRHFADRPSLRELFSPPLLrttLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 260 VFLFLMTLLNSRCVRRFGPVLMFRLglliqFSMGIWLVVVSALNLGFLPLVFGVAMFIG--CVSMVSSNAMAVILEEFPH 337
Cdd:cd17371 256 LGGFLGYLAGGFLADRIGRRNNFAL-----FALGSAISILLYFFLPLSPTLILILGFPLgfFASGPFSGMGAYLTELFPT 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490261258 338 MAGtASSLAGTLRFGVGG------LAGALLSALNFTSAWPMVVAMFICSTLSILLFL 388
Cdd:cd17371 331 AVR-ATAQGFCYNVGRIIgalfpfLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
11-290 |
1.60e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 56.10 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 11 LVVILgLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGP----LADSFGRKPVIAIGTLIFA 86
Cdd:cd17388 1 LIFIL-VTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 87 ITAAACAVAQTIEQLIYIRFLHGLSAAAGSVViSALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSwHAI 166
Cdd:cd17388 80 LDYLLMAFAPTLWWLYLGRIIAGITGATGAVA-AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISP-RAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 167 FWIISAVAVITTLLVVTQIKETLPKEKRQKFSLRA--TLGNFLLLFRHqRVLSYMLASGFSFaGLFAFINSGPFVY--IE 242
Cdd:cd17388 158 FLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRanPFGSLRWLTGF-PGLLGLLAVFFLI-QLIGQVPATTWVLftED 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 490261258 243 LNHISPQNFGYYFA-LNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQF 290
Cdd:cd17388 236 RFDWSPTMVGLSLAvFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADA 284
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-385 |
1.76e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.64 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 24 LSIDMY----LPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIE 99
Cdd:cd17478 6 FLNDFYqgflPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 100 QLIYIRFLHGLSAAA----GSVVISALmrdsySKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFW--IISAV 173
Cdd:cd17478 86 LLLLLVALAGIGSAAfhpeGARLASQA-----AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLIllIIPGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 174 AVITTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLFRhqRVLSYMLASGFSFAGLFAFInsgPFvYIELNHISPQNFGY 253
Cdd:cd17478 161 AVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALL--LLLIIVFLRSWVLSSLTTFL---PF-YLVQRGYSLVFAGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 254 YFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFigcvsMVSSNAMAVILE 333
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLF-----ASFPVTVVLAQE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490261258 334 EFPHMAGTASSLAGTLRFGVGGLAGALLSALnfTSAWPMVVAMFICSTLSIL 385
Cdd:cd17478 310 LLPGNVGLASGLMMGLSFGLGGIGAPVLGAL--ADAFGLESVLLILALLPLL 359
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-378 |
8.38e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 53.74 E-value: 8.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 17 LLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILgFSLGQLIYGP----LADSFGRKPVIAIGTLIFAITAAAC 92
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSS-YSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 93 AVAQTIEQLIYIRFLHGLSAAAGSVVISALMrDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISA 172
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGGNVSVAQAYIA-DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 173 VAVITTLLVvtqiketlpkekrqkfslratlgnFLLLFRHQRVLSYMLASGFSFAGLFAFInsgPFVYIELNHISPQNFG 252
Cdd:cd17330 161 LALLNLVLV------------------------LFFLPPLRRLLLVYFLIALAFAGLESVF---SLFLKDRFGFSPSQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 253 YYFALN-IVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLV---FGVAMFIGCVSMVSSNam 328
Cdd:cd17330 214 LLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAilaFGTGIVFPALSALLSK-- 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490261258 329 AVILEEFPHMAGTASSLAGTLRFGVGGLAGALLSALN-----FTSAWPMVVAMFI 378
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGpgvpfLLAAGLLLIALFL 346
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
32-176 |
3.07e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 48.96 E-value: 3.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:PRK10504 32 ALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490261258 112 AAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVI 176
Cdd:PRK10504 112 GAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGII 176
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
17-386 |
3.09e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.71 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 17 LLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQ 96
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 97 TIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLlwSWHAIFWIISAVAVI 176
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT--AGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 177 TTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLfrhqrvLSYMLASGFSFAGLFAFINsgpfVYIELNHISPQNFGYYFA 256
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLA------LLGAFVAGFLEGAFYSLLP----LYGLRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 257 LNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVssnAMAVILEEFP 336
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTL---ALALAGDRLP 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490261258 337 HMAGTASSLAGTLRFGVGGLAGALLSAL---NFTSAWPMVVAMFICSTLSILL 386
Cdd:cd17477 308 GDELVAANAALLLLYGLGSVIGPLLAGAlmdAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
56-389 |
1.75e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 46.41 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 56 LGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRM 135
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 136 MSFVLLVMTVAPLVAPILGGWVlllwSWHAIFWIISAVAVITTLLVV-----------------------------TQIK 186
Cdd:cd17358 132 GSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAIPPVVFLILLFfipesprwlakkgreeeaekslqflrgkdADIS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 187 ETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFS------FAGLFAFINSGPFVYIELNHISPQNFGY--YFALN 258
Cdd:cd17358 208 KEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGlmlfqqLSGINAVIFYASSIFDEAGSGLDPNTATiiIGVVQ 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 259 IVFLFLMTLLNSRCVRRfgPVLMFRLG------LLIQFSMGIWLVVVSALNLGFLPLVfGVAMFIGCVSM-VSSNAMAVI 331
Cdd:cd17358 288 VVGTLVATLLVDRLGRR--PLLLVSAIgmgiglLALGLYFYLQEHGALLSSVSWLPLV-GLVIYIISFSIgLGPLPWVIM 364
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490261258 332 LEEFP-HMAGTASSLAGTlrFGVGGLAGALLSALNFTSAWPMVVAMFICSTLSILLFLY 389
Cdd:cd17358 365 SEIFPaKIKGLAGSLVTL--VNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVF 421
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-234 |
2.34e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.06 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 15 LGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFG-RKPVIAIGTLIFAITAAACA 93
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 94 VAQTIEQLIYIRFLHGLsAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAV 173
Cdd:cd17490 81 LFPSPWGLLIARFLSGI-AAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490261258 174 AVITTLLVVTqIKETLPKEKRQKFSLRatlgNFLLLFRHQRVLSY----MLASGFSFAGLFAFIN 234
Cdd:cd17490 160 GVLGFILSLF-IKEERREKKPVLTELK----ELLSVLKDKKLLFFsllaILQQMITFSTTFGFTP 219
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-385 |
1.47e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 8 PAGLVVILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAI 87
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 88 TAAACAVAQTIEQLIYIRFL-HGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSW--- 163
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLlGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrta 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 164 HAIFWIISAVAVITTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPfVYIEL 243
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLV-PYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 244 NHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFlpLVFGVAMFIGCVSMV 323
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLAL--LLFAALFGLGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261258 324 SSNAMAVILEEFPHMAGTASSL---AGTLRFGVGGLAGALLSAL--NFTSAWPMVVAMFICSTLSIL 385
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLvfaPHQLGSALGPWLGGLLYDRtgSYTAAWALAVALGLIAALLVL 384
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
49-360 |
2.03e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 49 MTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFA---ITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRD 125
Cdd:pfam00083 50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVigaVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISE 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 126 SYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLL---LWSWHAIFWIISAVAVITTLLVVT------------------- 183
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKtsnSDGWRIPLGLQLVPALLLIIGLLFlpesprwlvekgrleeare 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 184 ----------------QIKETLPKEKRQKFSLRATLgnFLLLFRHQRVL-SYMLASGFSFAGLFAFINSGPFVYiELNHI 246
Cdd:pfam00083 210 vlaklrgvpdvdreldEIKDSLEAGQEAEKASWKEL--FSTKTRRQRLLiGVMLQIFQQLTGINAIFYYSTTIF-ENLGL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 247 SPqnfgyYFALNIVF---LFLMTLLNSRCVRRFGpvlMFRLGLLIQFSMGIWLVVVSALNLGFLP--------LVFGVAM 315
Cdd:pfam00083 287 SD-----SFLVTIIVgvvNFVFTFIAIFLVDRFG---RRPLLLLGAAGMAICFVILGIVALLGVSksdwagivAIVFIAL 358
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490261258 316 FIGCVSMVSSNAMAVILEEF--PHMAGTASSLAGTLRFGVGGLAGAL 360
Cdd:pfam00083 359 FIAFFAMGWGPVPWVIVSELfpLSVRSKAMALATAANWLANFLIGFL 405
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
125-388 |
2.10e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 125 DSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVITTLLVVTQIKEtlPKEKRQKFSLRATLG 204
Cdd:cd17471 116 DRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPS--VKPPAQKATPASSLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 205 NFLllfRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNSRCVRRFGPVLMFRL 284
Cdd:cd17471 194 KAP---VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLA 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 285 GLLIQFSMGIWLVVVSALnLGFLPLVFGVAMFIGcvsMVSSNAMAVILEEFPHMAGTASSL-AGTLRFGV---GGLAGAL 360
Cdd:cd17471 271 GFLAGVLFYLGLALATSL-WQLIALQLLNAIFIG---ITAGLGISYFQDLMPGQPGLATTLySNASRIGSllgGLLAGVI 346
|
250 260
....*....|....*....|....*...
gi 490261258 361 LSALNFTSAWpmvVAMFICSTLSILLFL 388
Cdd:cd17471 347 AQYFGYRAVF---LVCAVLALLALVLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-184 |
2.38e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 11 LVVILGLLAMLMPLSIDMYLPALPQIARE-FSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITA 89
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 90 AACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWI 169
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....*
gi 490261258 170 ISAVAVITTLLVVTQ 184
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-390 |
2.86e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.69 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 33 LPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSA 112
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 113 AAGSVVISALMRDSYSkEEFSRMMSFVLLVMTVAPLVAPILGGWVLL-LWSWHAIFWIISAVAVITTLLVVTQIKETLPK 191
Cdd:cd17333 99 GILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLIIGLIYLLLAILILLTLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 192 EKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFALNIVFLFLMTLLNSR 271
Cdd:cd17333 178 ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 272 CVRRFGPVLMFRLGLLIqfsmGIWLVVVSALNLGFLPLVFGVAMFIGCVSMVSSNAMAVILEEFPHMAGTASSLAGTLRf 351
Cdd:cd17333 258 ISRRIKPHTLLVLSGSG----ALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAG- 332
|
330 340 350
....*....|....*....|....*....|....*....
gi 490261258 352 GVGGLAGALLSALnFTSAWPMVVAMFICSTLSILLFLYA 390
Cdd:cd17333 333 SIGGAIIPFIMGF-IAEAVGIQTAMLLITILYAIIFVLA 370
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
14-388 |
4.68e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.82 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 14 ILGLLAMLMPLSIDMYLPALPQIAREFSVSA---GSVQMTLNVYILgfsLGQLIYGPLADSFGRKPVIAIGTLIFAITAA 90
Cdd:cd17331 4 IVHLNIVLYATCYWLQQPVLPYLTKKLGVDSvvfGYLQTTFSVLQL---VGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 91 ACAVAQTIEQLIYIR----FLHGLSAAagsvviSALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAI 166
Cdd:cd17331 81 LLAFASSVPMLFLSRlpsvFMHAMQAA------QMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 167 FW------IISAVAVITTLLVVTQIKETLPKEKRQKFSLRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVY 240
Cdd:cd17331 155 ALvaavgsLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 241 IELNHISPQNFGYYFALNIVFLFLMT-LLNSRCVRRFGPVLMFRLGLLIQFSMG---IWLVVVSALNLGFLPLVFGVAMF 316
Cdd:cd17331 235 MDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYlllAFVTTVWQLLVLLLPLVIGGSVL 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490261258 317 IGCVSMVSSNAMAvileefPHMAGTASSLAGTLRFGVGGLA----GALLSALNFTSAWpmVVAMFICSTLSILLFL 388
Cdd:cd17331 315 YTVITSLLTKAVP------PEDTGTALGLSHALFSLVRTVSptigGALLQAYGFPSFG--LLGAAINGLLTVYLLL 382
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
22-118 |
5.39e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 5.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 22 MPLSIDMYLPA----LPQIAREF---SVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAV 94
Cdd:TIGR00898 97 TEPCLDGWEYSydtfSSTIVTEWdlvCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF 176
|
90 100
....*....|....*....|....
gi 490261258 95 AQTIEQLIYIRFLHGLSAAAGSVV 118
Cdd:TIGR00898 177 SPNYTVFLVFRLLVGMGIGGIWVQ 200
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
52-182 |
8.18e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 8.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 52 NVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMrdsyskEE 131
Cdd:cd06179 39 TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVAS------EL 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 490261258 132 FSR-----MMSFVLLVMTVAPLVAPILGGWVLL--LWSWHAIFWIISAVAVITTLLVV 182
Cdd:cd06179 113 VPNkyrglVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINAIFNALALILLF 170
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
31-369 |
1.11e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.70 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 31 PALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAI-TAAACAVAQTIEQLIYIRFLHG 109
Cdd:cd17341 20 PLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 110 LSAAAGSVVISaLMRDSYSKEEfsrmmsFVLLVMT----------VAPLVAPILGGWVLLLWS---WHAIFWIISAVAVI 176
Cdd:cd17341 100 FAGANFASGQP-WASFWFPKEK------IGGAAGGiagagnmgvaVSQLLAPLIAGAIVFDGGfvgWRNAFFVPGILLAI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 177 TTLLVVTQIKeTLPKEKRQKfslRATLGNFLLLFRHQRVLSYMLASGFSFAGLFAFINSGPFVYIELNHISPQNFGYYFA 256
Cdd:cd17341 173 AAVLVLLFGD-DLPTGKASA---LEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 257 LNIVFLFLMTLLNSRCVRRFGPVLMFRLGLLIQFSMGIWLVVVSALNLGFLPLVFGVAMFIG-CVSMVSSNAMAVILEEF 335
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGlGAGAGNGSVFRMVPFIF 328
|
330 340 350
....*....|....*....|....*....|....
gi 490261258 336 PHMAGTASSLAGtlrfGVGGLAGALLSALNFTSA 369
Cdd:cd17341 329 RRELGAVTGLVG----AIGGLGGFFLPLLFGSSA 358
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
32-110 |
1.63e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 1.63e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGL 110
Cdd:PRK11551 37 AAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
32-177 |
1.74e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 40.32 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490261258 112 AAAGSVVISALMRDSYSKEEFsRMMSFVLLVMTvAPL---VAPILGGWVLLLWSWHAIFWIISAVAVIT 177
Cdd:cd17476 100 PAFLLPNAMALLGRTYPPGPR-KNIVFSLFGAT-APLgfaLGGVFGGLFAQLAWWPWIFWFLAILAAIV 166
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
58-210 |
2.04e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.95 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 58 FSLGQL----IYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSaaAGSVVIS-ALMRDSYSKEEF 132
Cdd:cd17389 73 FSLLQFlsspITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGIS--KGNVSLStAIVADVTSPKKR 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 133 SRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISA------VAVITTLLVVTQIKETLPKEKRqkfslRATLGNF 206
Cdd:cd17389 151 SKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPalfalvLALADLLFIFFFLPETLPSNLR-----RLGLVYF 225
|
....
gi 490261258 207 LLLF 210
Cdd:cd17389 226 LYLF 229
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
66-176 |
2.13e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 66 GPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTV 145
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
90 100 110
....*....|....*....|....*....|.
gi 490261258 146 APLVAPILGGWVLLLWSWHAIFWIISAVAVI 176
Cdd:cd17391 341 GNVAGPLLGSAIAAHFGYRAVFVVTALLVLL 371
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
32-182 |
2.26e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.04 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTlNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLs 111
Cdd:pfam06609 66 ALPNILQDIGQSENQGLFS-TLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGV- 143
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490261258 112 aAAGSVVISALmrdsYSKEEFSRMMSFVLLVMTVAPLVA-----PILGGWVLLLWSWHAIFWIISAVAVITTLLVV 182
Cdd:pfam06609 144 -AAGPAGASPL----FIGELMSNKTKFLGLLIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLII 214
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
47-180 |
2.94e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.49 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 47 VQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDS 126
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 490261258 127 YSKEEFSRMMSFVLLVMTVAPLvapILGGWVLLLWSWHAIFWIISAVAVITTLL 180
Cdd:cd17317 107 VGPKYRSFVGILFGLFWALGYM---LLALLAYLIRDWRWLQLAISLPGLLFLLL 157
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
32-123 |
5.95e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.70 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLHGLS 111
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90
....*....|..
gi 490261258 112 AAAGSVVISALM 123
Cdd:cd17359 103 VGGASALVPMYI 114
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
32-176 |
6.46e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 6.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLI--FAITAAACAVAQTIEQLIYIRFLHG 109
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLLTPLLAYSSLPLLILSRILLG 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490261258 110 LSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISAVAVI 176
Cdd:cd17380 101 LGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLL 167
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
13-163 |
7.41e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.37 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 13 VILGLLAMLMPLSIDMYLPALPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAAC 92
Cdd:cd17438 2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490261258 93 AVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSW 163
Cdd:cd17438 82 SFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGW 152
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
14-185 |
7.68e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 37.97 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 14 ILGLLAMLMPLSIDMYLpaLPQIAREFSVSAGSVQMTLNVYILGFSLGQLIYGPLA-DSFGRKPVIAIGTLIFAITAAAC 92
Cdd:cd17490 201 LLAILQQMITFSTTFGF--TPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLI 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 93 AVAQTIEQLIYIRFLHGLSAAAGSVVISALMRDSYSKEEFSRMMSFVLLVMTVAPLVAPILGGWVLLLWSWHAIFWIISA 172
Cdd:cd17490 279 PFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGV 358
|
170
....*....|...
gi 490261258 173 VAVITTLLVVTQI 185
Cdd:cd17490 359 IALLAAILSLAYY 371
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
32-119 |
9.53e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.02 E-value: 9.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261258 32 ALPQIAREF---SVSAGSVQMTLNVYILGFSLGQLIYGPLADSFGRKPVIAIGTLIFAITAAACAVAQTIEQLIYIRFLH 108
Cdd:cd17360 19 ALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLV 98
|
90
....*....|.
gi 490261258 109 GLSAAAGSVVI 119
Cdd:cd17360 99 GLGVGIASMTV 109
|
|
| |
