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Conserved domains on  [gi|490270598|ref|WP_004166871|]
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MurR/RpiR family transcriptional regulator [Pediococcus acidilactici]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
1-268 3.36e-78

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 238.29  E-value: 3.36e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   1 MNILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEATST---- 76
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEglss 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  77 ------ITEDVGNAPLPDQVTNFYNQMITGTWKKINQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAF 150
Cdd:COG1737   85 yerlrrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 151 A-PADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVDNTRF 229
Cdd:COG1737  165 LlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSA 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490270598 230 INSQLGIVYVIDVLSTML-LHNPDYKQHYQQTVEAILSRK 268
Cdd:COG1737  245 FSSRVAQLALIDALAAAVaQRDGDKARERLERTEALLSEL 284
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
1-268 3.36e-78

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 238.29  E-value: 3.36e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   1 MNILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEATST---- 76
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEglss 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  77 ------ITEDVGNAPLPDQVTNFYNQMITGTWKKINQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAF 150
Cdd:COG1737   85 yerlrrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 151 A-PADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVDNTRF 229
Cdd:COG1737  165 LlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSA 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490270598 230 INSQLGIVYVIDVLSTML-LHNPDYKQHYQQTVEAILSRK 268
Cdd:COG1737  245 FSSRVAQLALIDALAAAVaQRDGDKARERLERTEALLSEL 284
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
109-246 1.07e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 145.06  E-value: 1.07e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 109 ALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATK 188
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490270598 189 LAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVDNTRFINSQLGIVYVIDVLSTM 246
Cdd:cd05013   82 IAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
3-245 2.38e-35

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 133.50  E-value: 2.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   3 ILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEA-TSTITEDV 81
Cdd:PRK14101 343 VFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGlTGTIPMSH 422
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  82 GNAPLPDQVTNFYNQMITGTWKKI-------NQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPAD 154
Cdd:PRK14101 423 SQVHLGDTATDFGAKVLDNTVSAIlqlrehlNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGD 502
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 155 SHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAfDDSPLATMSDCKLFVQYSDFVDNTRFINSQL 234
Cdd:PRK14101 503 LYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITS-SNTPLAKRATVALETDHIEMRESQLSMISRI 581
                        250
                 ....*....|.
gi 490270598 235 GIVYVIDVLST 245
Cdd:PRK14101 582 LHLVMIDILAV 592
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
116-216 2.09e-17

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 76.18  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  116 LIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHT-MYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQ 194
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASElRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80
                          90       100
                  ....*....|....*....|..
gi 490270598  195 LKVIAITAFDDSPLATMSDCKL 216
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVL 102
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
1-268 3.36e-78

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 238.29  E-value: 3.36e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   1 MNILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEATST---- 76
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEglss 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  77 ------ITEDVGNAPLPDQVTNFYNQMITGTWKKINQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAF 150
Cdd:COG1737   85 yerlrrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 151 A-PADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVDNTRF 229
Cdd:COG1737  165 LlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSA 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490270598 230 INSQLGIVYVIDVLSTML-LHNPDYKQHYQQTVEAILSRK 268
Cdd:COG1737  245 FSSRVAQLALIDALAAAVaQRDGDKARERLERTEALLSEL 284
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
109-246 1.07e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 145.06  E-value: 1.07e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 109 ALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATK 188
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490270598 189 LAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVDNTRFINSQLGIVYVIDVLSTM 246
Cdd:cd05013   82 IAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
3-245 2.38e-35

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 133.50  E-value: 2.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   3 ILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEA-TSTITEDV 81
Cdd:PRK14101 343 VFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGlTGTIPMSH 422
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  82 GNAPLPDQVTNFYNQMITGTWKKI-------NQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPAD 154
Cdd:PRK14101 423 SQVHLGDTATDFGAKVLDNTVSAIlqlrehlNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGD 502
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 155 SHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAfDDSPLATMSDCKLFVQYSDFVDNTRFINSQL 234
Cdd:PRK14101 503 LYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITS-SNTPLAKRATVALETDHIEMRESQLSMISRI 581
                        250
                 ....*....|.
gi 490270598 235 GIVYVIDVLST 245
Cdd:PRK14101 582 LHLVMIDILAV 592
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
1-264 7.09e-32

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 118.56  E-value: 7.09e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   1 MNILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEATSTITED 80
Cdd:PRK11302   1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  81 VGNAPLPDQVTNFYNQMITGTW--------KKINQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAP 152
Cdd:PRK11302  81 VNRNVEEDDSVEAYTGKIFESAmasldharQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 153 ADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAfDDSPLATMSDCKLFVQYSDFVDNTRFINS 232
Cdd:PRK11302 161 DDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITS-AGSPLAREATLALTLDVPEDTDIYMPMVS 239
                        250       260       270
                 ....*....|....*....|....*....|....
gi 490270598 233 QLGIVYVIDVLST--MLLHNPDYKQHYQQTVEAI 264
Cdd:PRK11302 240 RIAQLTVIDVLATgfTLRRGAKFRDNLKRVKEAL 273
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
7-261 4.41e-30

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 113.71  E-value: 4.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   7 VEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEAtstitedVGNAPL 86
Cdd:PRK11557   3 IRQRYPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEA-------LASQPE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  87 PDQVTnFYNQMITGTWKKI--------NQTA------------LDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMG 146
Cdd:PRK11557  76 PPSVP-VHNQIRGDDPLRLvgeklikeNTAAmratldvnseekLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 147 INAFAPADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVDN 226
Cdd:PRK11557 155 INAVAERDMHALLATVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHCLYTIAEEQATR 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 490270598 227 TRFINSQLGIVYVIDVLSTMLL-----HNPDYKQHYQQTV 261
Cdd:PRK11557 235 SAAISSTHAQGMLTDLLFMALIqqdleRAPERIRHSEALV 274
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
10-213 1.90e-29

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 112.55  E-value: 1.90e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  10 KYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGL--------AEATSTITEDV 81
Cdd:PRK11337  22 KQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALedyfsqseQVLHSELSFDD 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  82 GNAPLPDQVTNFYNQMITGTWKKINQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHTMYIT 161
Cdd:PRK11337 102 APQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLMS 181
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490270598 162 SSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSD 213
Cdd:PRK11337 182 AALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLAD 233
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
103-218 1.21e-25

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 99.57  E-value: 1.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 103 KKINQTALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADShtmyITSSImQSDDLVIVLSVSGNSTE 182
Cdd:cd05005   16 DKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGET----TTPAI-GPGDLLIAISGSGETSS 90
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 490270598 183 VNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLFV 218
Cdd:cd05005   91 VVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVI 126
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
14-216 1.25e-23

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 96.69  E-value: 1.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  14 LSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEATSTITEDVGNAPLPDQVTNF 93
Cdd:PRK15482  14 FTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSIT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  94 YNQMITGTWKKINQT---ALDEA------------VQLIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHTM 158
Cdd:PRK15482  94 SDDSLEVIARKLNREkelALEQTcalfdyarlqkiIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQ 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490270598 159 YITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKL 216
Cdd:PRK15482 174 ATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTL 231
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
116-216 2.09e-17

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 76.18  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  116 LIKNAPRIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHT-MYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQ 194
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASElRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80
                          90       100
                  ....*....|....*....|..
gi 490270598  195 LKVIAITAFDDSPLATMSDCKL 216
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVL 102
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
1-76 4.53e-16

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 71.21  E-value: 4.53e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490270598    1 MNILEAVEQKYPSLSRQERKIALKVIQHPSQVKKMSIGILAKKAEVSTATVTRFVKKMGCQDFSEFKLGLAEATST 76
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELAN 76
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
104-213 2.09e-15

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 74.55  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 104 KINQTALDEAVQLIKNAPRIFVF--GLGSSGYNAQELSQRL-LRMGINAFAPADSHTMYITSSIMQSDDLVIVLSVSGNS 180
Cdd:COG2222   16 AALAAAIAALLARLRAKPPRRVVlvGAGSSDHAAQAAAYLLeRLLGIPVAALAPSELVVYPAYLKLEGTLVVAISRSGNS 95
                         90       100       110
                 ....*....|....*....|....*....|...
gi 490270598 181 TEVNEATKLAKEHQLKVIAITAFDDSPLATMSD 213
Cdd:COG2222   96 PEVVAALELAKARGARTLAITNNPDSPLAEAAD 128
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
105-213 4.60e-14

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 68.31  E-value: 4.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 105 INQTALDEAVQLIKNA----PRIFVFGLGSSGYNAQ----ELSQRLL--RMGINAFAPADsHTMYITS------------ 162
Cdd:cd05006   14 LLAEAIEQAAQLLAEAllngGKILICGNGGSAADAQhfaaELVKRFEkeRPGLPAIALTT-DTSILTAiandygyeevfs 92
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490270598 163 ----SIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSD 213
Cdd:cd05006   93 rqveALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRDGGKLLELAD 147
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
123-202 3.03e-12

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 61.24  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 123 IFVFGLGSSGYNAQELSQRLLRM-GINAFAPADSHTMY-ITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAI 200
Cdd:cd04795    1 IFVIGIGGSGAIAAYFALELLELtGIEVVALIATELEHaSLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80

                 ..
gi 490270598 201 TA 202
Cdd:cd04795   81 TD 82
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
109-218 6.83e-12

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 64.23  E-value: 6.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 109 ALDEAVQLIKNAP-RIFVFGLGSSGYNAQELSQRLLRMGINAFA--PAD-SHTmyiTSSIMQSDDLVIVLSVSGNSTEVN 184
Cdd:COG0794   32 SFEKAVELILNCKgRVVVTGMGKSGHIARKIAATLASTGTPAFFlhPAEaSHG---DLGMITPGDVVIAISNSGETEELL 108
                         90       100       110
                 ....*....|....*....|....*....|....
gi 490270598 185 EATKLAKEHQLKVIAITAFDDSPLATMSDCKLFV 218
Cdd:COG0794  109 ALLPLLKRLGVPLIAITGNPDSTLARAADVVLDL 142
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
122-218 1.40e-11

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 60.20  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 122 RIFVFGLGSSgYNA----QELSQRLLRMGINAFAPADSHtmYITSSImQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKV 197
Cdd:cd05008    1 RILIVGCGTS-YHAalvaKYLLERLAGIPVEVEAASEFR--YRRPLL-DEDTLVIAISQSGETADTLAALRLAKEKGAKT 76
                         90       100
                 ....*....|....*....|.
gi 490270598 198 IAITAFDDSPLATMSDCKLFV 218
Cdd:cd05008   77 VAITNVVGSTLAREADYVLYL 97
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
122-218 8.84e-11

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 58.32  E-value: 8.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 122 RIFVFGLGSSGYNAQELSQRLLRMGINAF--APADShtMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIA 199
Cdd:cd05014    2 KVVVTGVGKSGHIARKIAATLSSTGTPAFflHPTEA--LHGDLGMVTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIA 79
                         90
                 ....*....|....*....
gi 490270598 200 ITAFDDSPLATMSDCKLFV 218
Cdd:cd05014   80 ITGNPNSTLAKLSDVVLDL 98
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
94-201 3.52e-10

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 56.83  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598   94 YNQMITGTWKKINQT---ALDEAVQLI----KNAPRIFVFGLGSSGYNAQELSQRLL-RMGINAFAPAD---------SH 156
Cdd:pfam13580   2 YLDEVRALLERVVETqadAIEKAADLIaaslANGGKVYAFGTGHSAAPAEELFARAGgLAGFEPILLPAlalhtdasaTI 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 490270598  157 TMYI-----------TSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAIT 201
Cdd:pfam13580  82 STALerdegyarqilALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
168-213 2.34e-08

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 51.42  E-value: 2.34e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 490270598 168 DDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSD 213
Cdd:cd05710   48 KSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDEDSPLAKLAD 93
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
111-202 3.45e-06

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 47.28  E-value: 3.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 111 DEAVQLIKNAPRIFVFGLGSSGYnAQELSQRLLRMGINAfaPADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLA 190
Cdd:PRK08674  25 LDLEEDLEKIDNIVISGMGGSGI-GGDLLRILLFDELKV--PVFVNRDYTLPAFVDEKTLVIAVSYSGNTEETLSAVEQA 101
                         90
                 ....*....|..
gi 490270598 191 KEHQLKVIAITA 202
Cdd:PRK08674 102 LKRGAKIIAITS 113
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
122-202 4.14e-06

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 44.95  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 122 RIFVFGLGSSGYNAQELSQRLL-RMGINAFAPADshtmYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAI 200
Cdd:cd05017    1 NIVILGMGGSGIGGDLLESLLLdEAKIPVYVVKD----YTLPAFVDRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVAI 76

                 ..
gi 490270598 201 TA 202
Cdd:cd05017   77 TS 78
PRK02947 PRK02947
sugar isomerase domain-containing protein;
94-201 1.40e-05

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 45.25  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598  94 YNQMITGTWKKINQT---ALDEAVQL----IKNAPRIFVFGLGSSGYNAQELSQR-----------LLRMGINAFAPADS 155
Cdd:PRK02947   7 YFDAVIELLERVRETqaeAIEKAADLiadsIRNGGLIYVFGTGHSHILAEEVFYRagglapvnpilEPSLMLHEGAVASS 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 490270598 156 H--------TMYITSSIMQSDDLVIVLSVSGnsteVN----EATKLAKEHQLKVIAIT 201
Cdd:PRK02947  87 YlervegyaKAILDRYDIRPGDVLIVVSNSG----RNpvpiEMALEAKERGAKVIAVT 140
gmhA PRK00414
D-sedoheptulose 7-phosphate isomerase;
106-225 1.44e-05

D-sedoheptulose 7-phosphate isomerase;


Pssm-ID: 179012 [Multi-domain]  Cd Length: 192  Bit Score: 44.73  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 106 NQTALDEAVQLI----KNAPRIFVFGLGSSGYNAQELSQRLL------RMGINAFAPAD-SHTM---------YITS--- 162
Cdd:PRK00414  26 NIHAIQRAAVLIadsfKAGGKVLSCGNGGSHCDAMHFAEELTgryrenRPGYPAIAISDvSHLScvsndfgydYVFSryv 105
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490270598 163 -SIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLFVQYSDFVD 225
Cdd:PRK00414 106 eAVGREGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTGKDGGKMAGLADIEIRVPHFGYAD 169
gutQ PRK11543
arabinose-5-phosphate isomerase GutQ;
122-216 4.44e-05

arabinose-5-phosphate isomerase GutQ;


Pssm-ID: 183186 [Multi-domain]  Cd Length: 321  Bit Score: 43.99  E-value: 4.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 122 RIFVFGLGSSGYNAQELSQRLLRMGINAFAPADSHTMYITSSIMQSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAIT 201
Cdd:PRK11543  44 KVVVSGIGKSGHIGKKIAATLASTGTPAFFVHPAEALHGDLGMIESRDVMLFISYSGGAKELDLIIPRLEDKSIALLAMT 123
                         90
                 ....*....|....*
gi 490270598 202 AFDDSPLATMSDCKL 216
Cdd:PRK11543 124 GKPTSPLGLAAKAVL 138
PRK13936 PRK13936
phosphoheptose isomerase; Provisional
109-211 4.96e-05

phosphoheptose isomerase; Provisional


Pssm-ID: 237567  Cd Length: 197  Bit Score: 43.11  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 109 ALDEAVQLIKNAPRIFVFGLGSSGYNAQELSQRLL------RMGINAFAPA-DSHTmyITS----------------SIM 165
Cdd:PRK13936  32 AVELMVQALLNEGKILACGNGGSAADAQHFSAELLnrfereRPSLPAIALTtDTST--LTAiandysynevfskqvrALG 109
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 490270598 166 QSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAITAFDDSPLATM 211
Cdd:PRK13936 110 QPGDVLLAISTSGNSANVIQAIQAAHEREMHVVALTGRDGGKMASL 155
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
109-217 4.88e-04

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 41.18  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490270598 109 ALDEAVQLIKNAPRIFVFGLGSSgYNAQELSQRLlrmgINAFA--PADSHtmyITS------SIMQSDDLVIVLSVSGNS 180
Cdd:PRK00331 278 EGELADEDLKKIDRIYIVACGTS-YHAGLVAKYL----IESLAgiPVEVE---IASefryrdPVLSPKTLVIAISQSGET 349
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490270598 181 TEVNEATKLAKEHQLKVIAITAFDDSPLATMSDCKLF 217
Cdd:PRK00331 350 ADTLAALRLAKELGAKTLAICNVPGSTIARESDAVLY 386
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
166-201 7.75e-03

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 36.37  E-value: 7.75e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 490270598 166 QSDDLVIVLSVSGNSTEVNEATKLAKEHQLKVIAIT 201
Cdd:PRK13937 105 RPGDVLIGISTSGNSPNVLAALEKARELGMKTIGLT 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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