|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-397 |
2.02e-78 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 247.08 E-value: 2.02e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 38 TLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLL 117
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 118 STMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAIS 197
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 198 GFALAAAIMFWRILPESRHFRPTSLRpktLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVV 277
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLG---LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 278 GLLSVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRAR 356
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGpSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490280368 357 RARGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNGVGGFI 397
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
36-377 |
8.16e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 140.11 E-value: 8.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 36 RVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCS 115
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 116 LLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAA 195
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 196 ISGFALAAAIMFWRILPESRHFRPTSLRPktlliNFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQA 275
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRG-----SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 276 VVGLLSVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGL-LLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPR 354
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLlLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|....
gi 490280368 355 A-RRARGQASSLYLFSYYLGSSLA 377
Cdd:COG2814 325 ApPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-393 |
8.72e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.75 E-value: 8.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 41 LFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTM 120
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFA 200
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 201 LAAAIMFWRILPESRHFRPT-SLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYrLMMSPWSLSQAVVGL 279
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL-YAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 280 L-SVAYLTGTWSSPKAGAMTVRFGR-GPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-R 356
Cdd:cd17325 240 LfGAQGLASALSQPPAGKLSDRIGRkPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpP 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 490280368 357 RARGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNGV 393
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-391 |
1.21e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 98.42 E-value: 1.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGL 136
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPESRH 216
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 217 FRPTSLRPKTLLINFRLHWRDRGLpLLFVegFLLMGAFVTLFNYIGYR--LMMSPWSLSQAVVGLL----SVAYLTGTWS 290
Cdd:cd17320 180 EEKRKPLLSSLLRAYKRVLKNRRF-LGYA--LALGLSFAGLFAYLAAApfIYIEQLGLSPAQFGLLfalnAIALILGSLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 291 SPKAG---AMTVRFGRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRARGQASSLYL 367
Cdd:cd17320 257 NGRLVrrfGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLG 336
|
330 340
....*....|....*....|....
gi 490280368 368 FSYYLGSSLAGTLGGVFWHHYGWN 391
Cdd:cd17320 337 FLQFLIGALAGALVGLLPNGTALP 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-377 |
1.15e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.40 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 41 LFSAGLATFALLYCVQPILP-VLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLST 119
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 120 MMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGF 199
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 200 ALAAAIMFWRIL--PESRHFRPTSLRPKTLLINFRLHWRDRGLPLLFVeGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVV 277
Cdd:pfam07690 161 SLLAAVLLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 278 gLLSVAYLTGTWSSPKAGAMTVRFGRGP----VMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGP 353
Cdd:pfam07690 240 -LLGLGGLLGAIGRLLLGRLSDRLGRRRrlllALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*
gi 490280368 354 RA-RRARGQASSLYLFSYYLGSSLA 377
Cdd:pfam07690 319 LApKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-393 |
6.70e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 87.63 E-value: 6.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 55 VQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALI 134
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 135 GLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDfFGWRVALAAISGFALAAAIMFWRILPES 214
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 215 RhfRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAYLTGTWSSPKA 294
Cdd:cd17474 177 K--EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 295 GAMT-VRFGRGPVMLGFTAVMLCGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYY 371
Cdd:cd17474 255 GRLLkKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYNFVRF 334
|
330 340
....*....|....*....|..
gi 490280368 372 LGSSLAGTLGGVFWHHYGWNGV 393
Cdd:cd17474 335 LGQAVGPLLFGLLLEIFGLSAP 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-389 |
8.47e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.24 E-value: 8.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 35 MRVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACC 114
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 195 AISGFALAAAIMFWRILPESRHFRPTSlrPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGyRLMMSPWSLSQ 274
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAA--AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP-PYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 275 AVVGLL-SVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFS--SLWLIFIGMLLFSAGFFAAHSVASSWI 351
Cdd:COG2223 241 ATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350
....*....|....*....|....*....|....*....
gi 490280368 352 GPR-ARRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:COG2223 321 PDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-393 |
1.20e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.85 E-value: 1.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 28 KRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTA 107
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 108 LLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFF 187
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 188 GWRVALAAISGFALAAAI-MFWrilpesrhfrptslrpktllinfrlhwrdrglpLLFVEGFLLMGAFVTLFNYIGYRLM 266
Cdd:COG2271 162 GWRAAFLILGLPGLLLALlRFW---------------------------------LLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 267 MS-PWSLSQAVvGLLSVAYLTGTWSSPKAGAMTVRFGRG---PVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFA 342
Cdd:COG2271 209 EVrGLSLAQAG-LLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490280368 343 AHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNGV 393
Cdd:COG2271 288 AFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
20-389 |
1.28e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.85 E-value: 1.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 20 ASRPDPFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIG 99
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 100 RKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLL 179
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI-AVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 180 TGVFTDFFGWRVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTLlinfRLHWRDRGLPLLFVEGFLLMGAFVTLFN 259
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL----RSLWRSPLAWLLTLFFGLQSLLYYAVVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 260 YIGYRLMMSPWSLSQAvVGLLSVAYLTGTWSSPKAGAMTVRFG-RGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSA 338
Cdd:COG2807 237 WLPPILRDAGLSAATA-GLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490280368 339 GFFAAHSVASSWIGPRARRAR--GQASSLYLFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:COG2807 316 GQGGLFPLALTLIGLRARTPAeaAALSGMAQSVGYLLAALGPLLVGALHDATG 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-385 |
2.23e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.24 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 41 LFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTM 120
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDF--FGWRVALAAISG 198
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 199 FALAAAIMFWRILPESRH---FRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQA 275
Cdd:cd06174 161 LALLAAILLLLVVPDPPEsarAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 276 VVGLLSVAYLTGTWSSPKAGAMTVRFG--RGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIG- 352
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIgrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAe 320
|
330 340 350
....*....|....*....|....*....|...
gi 490280368 353 PRARRARGQASSLYLFSYYLGSSLAGTLGGVFW 385
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
58-362 |
8.60e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 78.55 E-value: 8.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 58 ILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLS 137
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPESRHF 217
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 218 ----RPTSLRPKTLLINFRLHW---------------------------RDRGLPLLFVEGFLLMGAFVTLFNYIGYRLM 266
Cdd:TIGR00895 199 lvskRPETVRRIVNAIAPQMQAeaqsalpeqkstqgtkrsvfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 267 MSPWSLSQAVVGLLSVaYLTGTWSSPKAGAMTVRFGRGPVMLGF--TAVMLCGLLLTLFSSLWLIFIGML--LFSAGFFA 342
Cdd:TIGR00895 279 ELGFSLSLAATGGALF-NFGGVIGSIIFGWLADRLGPRVTALLLllGAVFAVLVGSTLFSPTLLLLLGAIagFFVNGGQS 357
|
330 340
....*....|....*....|
gi 490280368 343 AHSVASSWIGPRARRARGQA 362
Cdd:TIGR00895 358 GLYALMALFYPTAIRATGVG 377
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-384 |
1.14e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.92 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 41 LFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTM 120
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 121 MTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFA 200
Cdd:cd17504 81 APNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 201 LAAAIMfwrilpesrhfrptslrpkTLLINFRLhWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWS---LSQAVV 277
Cdd:cd17504 160 VLLAAL-------------------VPLIDLRL-LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTgfgLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 278 GLLSVAY-LTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLF--SSLWLIFIGMLLFSAGF-FAAHSVASSWIGP 353
Cdd:cd17504 220 GLLLLPGaLVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlhSSLWALVVALLLIGIGLgLAFASLPNIVVES 299
|
330 340 350
....*....|....*....|....*....|.
gi 490280368 354 RARRARGQASSLYLFSYYLGSSLAGTLGGVF 384
Cdd:cd17504 300 VPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-389 |
9.19e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.16 E-value: 9.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 41 LFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTM 120
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFA 200
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 201 LAAAIMFWRIlpesrhfRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTlFNYIGYRLMMSPWSLSQAVVGLL 280
Cdd:cd17489 161 LLALLLVFLV-------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIA-YGAISTFLPLYAAERGISNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 281 SVAY-LTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRA 358
Cdd:cd17489 233 FTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAgSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350
....*....|....*....|....*....|..
gi 490280368 359 -RGQASSLYLFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:cd17489 313 rRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
58-387 |
1.44e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 68.35 E-value: 1.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 58 ILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMfwrilpeSRHF 217
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL-------ARTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 218 RPTSLrpktllinfrlhwrdrglpLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSqavvGLLSVAYLTGTWSSPKAGAM 297
Cdd:cd17321 171 SGAVL-------------------AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG----LALLPLALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 298 TVRFGRGPVMLGFTAVMLCGLLLTLF----SSLWLIFIGMLLFSAGF-FAAHSVASSWIGPRARRARGQASSLYLFSYYL 372
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALlgadSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
|
330
....*....|....*
gi 490280368 373 GSSLAGTLGGVFWHH 387
Cdd:cd17321 308 GGALGVALLGALLTA 322
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
55-383 |
2.07e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.97 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 55 VQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALI 134
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 135 GLSLSGVAAVGMTYLSEeIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPES 214
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 215 RHFRPTSLRPKTLLINFRLHWRdrGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVgLLSVAYLTGTWSSPKA 294
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWR--ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGL-LLSLFLFAGAIGTLIG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 295 GAMTVRFGRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRARGQASSLYL-FSYYLG 373
Cdd:cd17478 251 GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMgLSFGLG 330
|
330
....*....|
gi 490280368 374 SSLAGTLGGV 383
Cdd:cd17478 331 GIGAPVLGAL 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
36-211 |
2.73e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.60 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 36 RVTLALFSAGLATFALLYCVQPILPV-LSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACC 114
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 490280368 195 AISGFALAAAIMFWRIL 211
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-389 |
2.91e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.57 E-value: 2.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 31 TPQFMRVTLALFSAGLATFALLYCVQ-PILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALL 109
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWgPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 110 LAACCSLLSTMMTSWHGILIMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDF--- 186
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGL-GLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 187 FGWRVALAAISGFALAAAIMFWRI-LPESrhfRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRL 265
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSkLPEI---EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 266 MMS---PWSLSQAVVGLLSVAYLTGTWSspkAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFSS-LWLIFIGMLLFSAGFF 341
Cdd:COG0738 238 KDVlglSEATAALGLSLFWGGMTIGRFL---GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPgPWLALIGLALVGLGLS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490280368 342 AAHSVASSWIGPRARRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
35-315 |
3.77e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.37 E-value: 3.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 35 MRVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACC 114
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 195 AISGFALAAAIMFWRiLPESRHFRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQ 274
Cdd:COG0477 173 INAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 490280368 275 AVVGLLSVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVML 315
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
92-397 |
5.00e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 66.86 E-value: 5.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 92 GPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGlslSG-VAAVGMTYLSEEIHPSFVAFSMGLYISGNS 170
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG---SGaISSVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 171 IGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTLLINFRLHWRDRGLPLL-FVEGFL 249
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSiFILHFV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 250 LMGAFVTLfnyigyrlmmsPWSLSQAVVGLLSV--AYLTGTWSSPKAGAMTVRFGRGP------VMLGFTAVMLCGLLLT 321
Cdd:cd17472 210 LMAFFYIL-----------PLLLTQLGGGKGQLwkVYLPAILIGFILMVPFVIYAEKKgkmkqvFVSSILLIAVGFLLLL 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490280368 322 LFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRAR-RARGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNGVGGFI 397
Cdd:cd17472 279 FAAtSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPkEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTI 356
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
37-397 |
1.05e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 65.66 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 37 VTLALFSAGLATFALLycvqPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSL 116
Cdd:cd17477 1 LLLSVALLGLGSGLLL----PLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 117 LSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFtDFFGWRVALAAI 196
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 197 SGFALAAAIMFWRILPESRHFRPTSLRPKTLLinfrlhwrdRGLPLLFVEGF---LLMGAFVTLFNYIGYRLMMSpwslS 273
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLL---------RIAPLALLGAFvagFLEGAFYSLLPLYGLRLGLS----V 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 274 QAVVGLLSVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAV-MLCGLLLTLFSSL-WLIFIGMLLFSAGFFAAHSVASSWI 351
Cdd:cd17477 223 AQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLgALAALLLPLVPGLpLALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490280368 352 GPRARRA-RGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNGVGGFI 397
Cdd:cd17477 303 GDRLPGDeLVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFL 349
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
57-380 |
4.50e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 63.78 E-value: 4.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGL 136
Cdd:PRK11102 12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPES-R 215
Cdd:PRK11102 92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETlP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 216 HFRPTSLRPKTLLINFRLHWRD-RGLPLLFVEGFLLMGAFVTL----FNYI----------GYRLMMSpwslsqaVVGLL 280
Cdd:PRK11102 172 KERRQPFHLRTTIRNFASLFRHkRVLGYMLASGFSFAGMFSFLtagpFVYIelngvspqnfGYYFALN-------IVFLF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 281 SVAYLTGTWSSpKAGAMTvrfgrgpvMLGFtavmlcGLLLTLFSSLWLI--------FIGMLLFSAGFFAAHSVASSwig 352
Cdd:PRK11102 245 VMTIINSRFVR-RVGALN--------MLRF------GLWIQFIMGIWLVvsalldlgFWALVVGVAAFVGCVSMISS--- 306
|
330 340 350
....*....|....*....|....*....|
gi 490280368 353 prarraRGQASSLYLFSYYLG--SSLAGTL 380
Cdd:PRK11102 307 ------NAMAVILDEFPHMAGtaSSLAGTL 330
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
55-365 |
4.55e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.80 E-value: 4.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 55 VQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALI 134
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 135 GLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPES 214
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 215 RHFRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGA-FVTLFNYIGYRLMMSPWSLSQAVVgLLSVAYLTGTWSSPK 293
Cdd:cd17475 175 PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPqFALLTFLLLFLHDHLGLSVVAAGA-LLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 294 AGAMTVRFGRG---PVMLGFTAVMLCGLLLTLF----SSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSL 365
Cdd:cd17475 254 LGRVSDRVFGGrrrPVLVITAAIAAAALLVLSLlspgTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAgPEQAGTALGL 333
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
58-342 |
6.23e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 60.29 E-value: 6.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 58 ILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILpesrhf 217
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 218 rptslrpktllinfrlhwrdrglpLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAyLTGTWSSPKAGAM 297
Cdd:cd17365 175 ------------------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLN-IGGVIGSLLLGWL 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 490280368 298 TVRFGRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFA 342
Cdd:cd17365 230 ADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACV 274
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
57-373 |
3.66e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 3.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEF-GVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIG 135
Cdd:cd17473 20 PALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 136 LSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDfFGWRVALaAISGFALAAAIMFWRILPESR 215
Cdd:cd17473 100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPF-LVYLLALPVLILVLLFLPEPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 216 HFRPTSLRPKTLLiNFRLHWRdRGLPLLFVeGFLLMGAFVTLFNYIGYrLMMSPWSLSQAVVGL-LSVAYLTGTWSSPKA 294
Cdd:cd17473 178 RKSKSAASPGAAT-AAALPWK-RVLPIYFL-AFLAMLLFYVIPIQLPF-LLQERGGGSAALIGLaLAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 295 GAMTVRFGRGPVMLGFTAVMLCG-LLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYL 372
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFALMALGfLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFL 333
|
.
gi 490280368 373 G 373
Cdd:cd17473 334 G 334
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-215 |
3.81e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.96 E-value: 3.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 38 TLALFSAGLATFALLYCVQPILPV-LSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGR--KPVMVTALLLAACC 114
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|.
gi 490280368 195 AISGFALAAAIMFWRILPESR 215
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
57-380 |
4.41e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 57.78 E-value: 4.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGL 136
Cdd:TIGR00710 26 PAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPESRH 216
Cdd:TIGR00710 106 GASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 217 FRPTSLRPKTLLiNFRLHWRDRGLPL-LFVEGFLLMGAFVtlFNYIGYRLMMSPWSLSQAVVGLL----SVAYLTGTWSS 291
Cdd:TIGR00710 186 YEARIQISTYFE-TFLLLLKSKMFWGyALIYGASFGGFFA--FFSGAPFVYIDIMGVSPSVFGLLfalnIIAMIFGGFLN 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 292 PKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFSSL--WLIFIG-MLLFSAGFFAAHSVASSWIGPRARRARGQASSLYLF 368
Cdd:TIGR00710 263 GRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLgsWAMIIGpMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGT 342
|
330
....*....|..
gi 490280368 369 SYYLGSSLAGTL 380
Cdd:TIGR00710 343 LRLVLGAIVGYL 354
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-378 |
5.48e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 5.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 38 TLALFSAGLATFALLYCVQPILPVLSNEF--GVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCS 115
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 116 LLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFF----GWRV 191
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 192 ALAAISGFALAAAIMFWRILpesrhfrptslrpktllinfrlhwrdrglpLLFVEGFLLMGAFVTLFNYIGYRLMMSPWS 271
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL------------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 272 LSQAVVGLLSVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLF---SSLWLIFIGMLLFSAGFFAAHSVAS 348
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllsGSPTLLLLLLFILSFFVGGVWGALY 290
|
330 340 350
....*....|....*....|....*....|...
gi 490280368 349 SWIG---PRARRARGQAsslylFSYYLGSSLAG 378
Cdd:cd17316 291 AYLAelfPTEVRATGVG-----LSYNLGRLGGG 318
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
82-214 |
1.51e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 53.04 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 82 AMLAVGLLFTGPLS----DAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSF 157
Cdd:TIGR00880 5 AGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490280368 158 VAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPES 214
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-389 |
8.95e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.81 E-value: 8.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 36 RVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCS 115
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 116 LLSTMMTS-WHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:cd17355 83 VLLALATSlWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 195 AISGFALAAAI----MFWRILPESRHFRPTSLRPKTLLINFRLHWRDRGLPLL----FVEGFLLMGAFVTLFNYIGYRLM 266
Cdd:cd17355 163 VLALLALLVLVpvllLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLalafFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 267 msPWSLSQAVVGLLSVAYLTGTWSSpkaGAMTVRFGRGPVMLGF---TAVMLCGLLLTLFSSLWLIFIGMLLfsaGFFAA 343
Cdd:cd17355 243 --SPAAAAVALALIGLFNIVGRLLS---GWLGDRYSPRRLLAASyalRALGLALLLLLPFPPLALLLFAALF---GLGWG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 490280368 344 HSVASSWIGPRARRARGQASSLY---LFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:cd17355 315 ATVPLTAALAARYFGARSYGTLFglvFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
58-384 |
8.98e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.73 E-value: 8.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 58 ILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPESrhf 217
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 218 rptslrpktllinfrlhwrdrglpLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLL-SVAYLTGTWSSPKAGA 296
Cdd:cd17319 182 ------------------------WGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 297 MTVRFGRG----PVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYY 371
Cdd:cd17319 238 LSDRLLRGarrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLpGEAAATAGGLINSGGN 317
|
330
....*....|...
gi 490280368 372 LGSSLAGTLGGVF 384
Cdd:cd17319 318 LGGFVAPLLIGYL 330
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
83-360 |
9.11e-08 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 53.84 E-value: 9.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 83 MLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGI--------LIMRALIGLSLSGVAAVGMTYLSEEIH 154
Cdd:cd17367 52 MRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 155 PS----FVAFSMGLYISGNSIGGMSGRLLTGVFTD----FFGWRVALAAISGFALAAAIMfWRILPESRHFRPTSLRPKT 226
Cdd:cd17367 132 PGrrgfYSSFQYVTLIGGQLLALGVLLVLQHTLGEdqmaAWGWRIPFLLGGVLAVVVLWL-RRGLEETESFEAIAESNEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 227 ---LLINFRLHWRdrglPLLFVEGFLLMG--AFVTLFNYIGYRLM----MSPWSLSQAVVGLLSVAYLTgtwsSPKAGAM 297
Cdd:cd17367 211 sagTLRELRRHPR----ELLLVVGLTAGGtlAFYTWTTYLQKFLVntagFSKGDATWITTAALLVFMLL----QPLGGRL 282
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490280368 298 TVRFGRGPVMLGFT---AVMLCGLLLTL--FSSLWLIFIGM---LLFSAGFFAAHSVASSWIGPRARRARG 360
Cdd:cd17367 283 SDRIGRRPLLLFFGiggTLATVPLLSALdhTDSPYTAFALVlvgLVFLSGYTSINAVVKAELFPTHVRALG 353
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-396 |
1.18e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.32 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIG-RKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIG 135
Cdd:cd17370 20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILER 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 136 LSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFG----WRVALAAISGFALAAAIMFWRIL 211
Cdd:cd17370 100 LGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGgnyrTIFLLAAIPALLALLILLFVVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 212 PESRHFRPTSLRPKTLLINFRLHWRdrglpllfvegFLLMGAFVTLFNY----IGYRLMMSPWSLSQAVVgLLSVAYLTG 287
Cdd:cd17370 180 YPRPPKLRKKSKKTSLKKLPKAFWL-----------YLLAVALFALGNFsfafLILRAQELGLSAALIPL-LYALFNLVY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 288 TWSSPKAGAMTVRFGRGPVM-LGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRAR-RARGQASSL 365
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKKLLiLGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPaELRGTAYGL 327
|
330 340 350
....*....|....*....|....*....|.
gi 490280368 366 YLFSYYLGSSLAGTLGGVFWHHYGWNGVGGF 396
Cdd:cd17370 328 FNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
55-339 |
1.29e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 53.40 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 55 VQPILPVLSNEFGVSPASSSISLsisTAMLAVGLLF---TGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMR 131
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSM---TAYLAGGMFLqwlLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 132 ALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRIL 211
Cdd:PRK15402 109 FLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 212 PESRHFRPTSLRPKTLLINFRLHWRDRGlpllFVEGFLLMG-AFVTLFNYIGYR--LMMSPWSLSQAVVGLLSV------ 282
Cdd:PRK15402 189 PETAGRVGEKLSLKELGRDYKLVLKNRR----FVAGALALGlVSLPLLAWIALSpvILISGEQLSSYEYGLLQVpvfgal 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490280368 283 -------AYLTGTWSSPKagamTVRFGRGPVMLGfTAVMLCGLLLTLFSSLWLIfIGMLLFSAG 339
Cdd:PRK15402 265 iagnltlARLTSRRPLRS----LIRMGLWPMVAG-LLLAALATVISSHAYLWLT-AGLSLYAFG 322
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
156-391 |
4.95e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.44 E-value: 4.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 156 SFVAFSMGLYISGNSIGGMSGRLLTGVF--TDFFGWRVALAAISGFALAAAIMFWRILPESRHFRPTslrPKTLLINFRL 233
Cdd:COG2211 147 RLSSWRFAFAGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---KVSLKESLKA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 234 HWRDRGLPLLFVEGFLLMGAFVTLFNYIGYrLMMSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRFGRGPVMLGFTA 312
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLY-YFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 313 VMLCGLLLTLF---SSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA--------RRARGQASSLYLFSYYLGSSLAGTLG 381
Cdd:COG2211 303 LAALGLLLLFFlgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALA 382
|
250
....*....|
gi 490280368 382 GVFWHHYGWN 391
Cdd:COG2211 383 GLLLALFGYV 392
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
58-342 |
8.33e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 8.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 58 ILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLS 137
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLT----GVFTDFFGWRVaLAAISGFALAAAIMFWRILPE 213
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAallfPLLPPEIAWRV-LFLLGALPALLVLFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 214 S------RHFRPTSLRPKTLLINFRLHWRDRGLPLLFVEGFLLMGAFVTLF---NYIGYRLMMSPWSLSQAVVGLLSVAY 284
Cdd:cd17371 180 PpqwqaaRAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTwlpSYLTGERGLSFEGSAGYLVVTILGGF 259
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 490280368 285 LtGTWSspkAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFA 342
Cdd:cd17371 260 L-GYLA---GGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFA 313
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
34-339 |
2.05e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 49.56 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 34 FMRVTLALFSAGLATfallycVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGP----LSDAIGRKPVMVTALL 109
Cdd:cd17388 3 FILVTVLLDAMGIGL------IMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 110 LAACCSLLSTMMTSWHGILIMRALIGLSlSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFfGW 189
Cdd:cd17388 77 GAALDYLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 190 RVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTLLINFRLHWRDRGLPL---LFVEGFLLMGA----FVTLFNYIG 262
Cdd:cd17388 155 RAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGllgLLAVFFLIQLIgqvpATTWVLFTE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 263 YRLMMSPWS--LSQAVVGLLSV---AYLTGtWSSPKAGAmtvrfgRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFS 337
Cdd:cd17388 235 DRFDWSPTMvgLSLAVFGLLHAlfqAFVTG-PIAKRLGE------KRAILLGLAADALGFLLLAFATQGWMVFPILILLA 307
|
..
gi 490280368 338 AG 339
Cdd:cd17388 308 LG 309
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
89-393 |
3.09e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.77 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 89 LFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAA-----VGMTYLSEEIHPSFVAFSMG 163
Cdd:cd06173 52 PFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaffgpARQALLPELVPKEQLVRANA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 164 LYISGNSIGGMSGRLLTGVFTDFFG--WRVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTLLINFRLHWRDRGLP 241
Cdd:cd06173 132 LNSLATQLARIIGPALGGLLVALLGpgGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 242 LLFVEG---FLLMGAFVTLFNYIGYR-LMMSPWSLSQAV----VGLLSVAYLTGTWSSpkagamtvRFGRGPVMLGFTAV 313
Cdd:cd06173 212 LLLLALalfALLGGALTVLLPLLAKEvLGGGAAGYGLLLaafgVGALLGALLLGRLSK--------RRRRGRLLLIGALL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 314 M-LCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRA-RGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWN 391
Cdd:cd06173 284 LgLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
..
gi 490280368 392 GV 393
Cdd:cd06173 364 AV 365
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
23-261 |
3.63e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 48.67 E-value: 3.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 23 PDPFIKRGTPQFMRVTLAL--FSAGLATfallYCVQPILPVLSNEFG--VSPASSSISLSISTAMLAVGLLftGPLSDAI 98
Cdd:PRK15403 5 PRFFARHAATLFFPMALILydFAAYLTT----DLIQPGIINVVRDFNadVSLAPASVSLYLAGGMALQWLL--GPLSDRI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 99 GRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRL 178
Cdd:PRK15403 79 GRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 179 LTGVFTDFFGWRVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTLLINFRLHWRDRglpllfvegFLLMGAFVTLF 258
Cdd:PRK15403 159 SGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNR---------LFLTGAATLSL 229
|
...
gi 490280368 259 NYI 261
Cdd:PRK15403 230 SYI 232
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
57-318 |
8.08e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.59 E-value: 8.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEFGVSPASSSISLSIStaMLAVGL--LFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALI 134
Cdd:PRK11652 29 PAIADMARDLNVREGAVQAVMAAY--LLTYGLsqLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 135 GL--SLSGVAAVGMT---YLSEEIHPSFVAFSMGLYISgnsigGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWR 209
Cdd:PRK11652 107 GLgtGVGGVMARTLPrdlYEGTQLRHANSLLNMGILVS-----PLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 210 ILPESrhfRPTSLRPKTLLINFRLHWRDRGLpllfvEGFLLM--GAF--VTLFNYIGYRLMMSPWSLSQAVVGLLSV--- 282
Cdd:PRK11652 182 WMPET---RPADARRTRVLASYRTLLSNRRF-----NCYLLMliGTLagIAVFEACSGVLMGAVLGLSSMTVSILFIlpi 253
|
250 260 270
....*....|....*....|....*....|....*..
gi 490280368 283 -AYLTGTWSspkAGAMTVRFGRgpvmLGFTAVMLCGL 318
Cdd:PRK11652 254 pAAFFGAWF---AGRPNKRFST----LMWQSVICCLL 283
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
59-391 |
1.88e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.42 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 59 LPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMfwrilpesrhfr 218
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 219 ptslrpkTLLINFRLhWRDR----GLPLLFVEGFLLMGAFVT----LFNYIGYR-----LMMSPWSLSQAVvgllsvayl 285
Cdd:cd17503 167 -------APLLDLRL-FKDRnftlGLLLSFLLGLGLFGAMFLlplyLQNVLGYSafesgLVLAPGGLASAI--------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 286 tgtwSSPKAGAMTVRFG-RGPVMLGFTAVMLCGLLLTLF---SSLWLIFIGMLLFSAGFFAAHSVASSW-IGPRARRARG 360
Cdd:cd17503 230 ----LSPLVGRLLDKFGpRLLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLaLNSLPPEQIG 305
|
330 340 350
....*....|....*....|....*....|.
gi 490280368 361 QASSLYLFSYYLGSSLAGTLGGVFWHHYGWN 391
Cdd:cd17503 306 DATALFNTIRQLGGSIGTALLATLLTNRTQF 336
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
86-389 |
1.93e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 86 VGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPS--FVAFSMg 163
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEnrTRAFSL- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 164 LYISGNsIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWrILPESRHFRPTSlRPKTLLINFRLHWRDRGLPLL 243
Cdd:cd17329 129 LYWAIN-LGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF-LLPETRPKRRAA-EKTEILRGYKIVLRDRAFLLF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 244 FVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAYLTGTWSSPKAGAMTVRFGRGPVM-LGFTAVMLCGLLLTL 322
Cdd:cd17329 206 LLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILmIGILLFAIGFAVLAF 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490280368 323 FSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:cd17329 286 ANTLAVLILAMIVLTLGEMLVFPAVQTLVAALApPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
58-220 |
2.80e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 46.23 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 58 ILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLS 137
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 138 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRvALAAISGFALAAAIMFWRILPESRHF 217
Cdd:PRK03893 122 MAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR-ALFFIGILPIIFALWLRKNLPEAEDW 200
|
...
gi 490280368 218 RPT 220
Cdd:PRK03893 201 KEK 203
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
236-393 |
3.13e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 236 RDRGLPLLFVEGFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRFGRGPVMLGFTAVM 314
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 315 LCGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNG 392
Cdd:COG2814 86 ALGSLLCALApSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
.
gi 490280368 393 V 393
Cdd:COG2814 166 V 166
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-173 |
6.30e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 9 TVPAGEVSVAGASRPDPFIKRGTPQFMRVTLALFSAGLATFALLYCVQPIlpvLSNEFGVSPASSSISLSISTAMLAVGL 88
Cdd:COG2814 184 LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY---LQEVLGLSASAAGLLLALFGLGGVLGA 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 89 LFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISG 168
Cdd:COG2814 261 LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
....*
gi 490280368 169 NSIGG 173
Cdd:COG2814 341 FFLGG 345
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
57-211 |
6.42e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 6.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 57 PILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGL 136
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490280368 137 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVA---LAAISGFALAAAIMFWRIL 211
Cdd:cd17323 100 FGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIfwfLAIISGFCLILIFLFLPIV 177
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
191-397 |
1.11e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.53 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 191 VALAAISGFALAAAIMFWRI--LPES---RHFRPTSLRPKTLLINFRLHWRDRGLpLLFVEG---FLLMGAFVTLfNYIG 262
Cdd:PRK08633 180 PAGLVLLAVAVLGLIFAYRLpkVPAAapeVFDKKKYLFPKLLWRNLKLLRSDRVL-WLAIIGlsyFWFISQLAQA-NFPA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 263 Y---RLMMSPWSLSQAVVGLLSV-----AYLTGTWSSPKagamtVRFGRGPvmLGFTAVMLCGLLLTLFSSLWLIFIGML 334
Cdd:PRK08633 258 YakeVLGLDNTFQVQYLLAASAIgigigSLLAGRLSGRH-----IELGLVP--LGALGLALSLFLLPTAPSLASVLVLFF 330
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 335 LF--SAGFFaahSVA-SSWIGPRARRA-RGQ---ASSLYLFSYYLGSSLAGTLggvfWHHYGWNGVGGFI 397
Cdd:PRK08633 331 LFgfSAGLF---IVPlNALIQFRAPEKeLGKvlaANNFLQNVGMLLFLALTTL----FSGLGLSPAGLFY 393
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-216 |
1.73e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.33 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 11 PAGEVSVAGASRPDPFIKRGTPQFMRVTLALFsaglATFALLYCVQPILP-VLSNEFGVSPASSSISLSISTAMLAVGLL 89
Cdd:COG2223 184 PAGAAAAAKASLRDQLEALRDPRFWLLSLLYF----GTFGSFIGFSSWLPpYLVDQFGLSAATAGLLAALFALLGALGRP 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 90 FTGPLSDAIGRKPVM-VTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISG 168
Cdd:COG2223 260 LGGWLSDRIGGRRVLlIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAA 339
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 490280368 169 NSIGGMSGRLLTGVFTDFFG-WRVALAAISGFALAAAIMFWRILPESRH 216
Cdd:COG2223 340 GGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
89-389 |
1.78e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 43.58 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 89 LFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTsWHGILIMRALIGLSLSG-----------VAAVGMTYLSEEIhPSF 157
Cdd:pfam05977 63 IPAGALADNFDRRKIMLAGQLLLALVSTLLTLLA-GLGLLSPWLLLGLTFLGgigtalmdpawQASVPELVPRRDL-PAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 158 VAF-SMGLYISgNSIGGMSGrlltGVFTDFFG--WRVALAAISGFALAAAIMFWRilpesRHFRPTSLRPKTLLINFRLH 234
Cdd:pfam05977 141 VALnSVGYNIA-RSVGPALG----GVLLAAFGpaFTFALNALSYFAVIAALWRWK-----RAAPASPLPRERIFGAVRAG 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 235 WR----DRGLPLLFVEG---FLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAYLTGTWSSPKagaMTVRFGR-GPV 306
Cdd:pfam05977 211 LRftamSRELRSVLVRAfafGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPR---LRERLGSdRLV 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 307 MLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHS---VASSWIGPRARRARgqASSLYLFSYYLGSSLAGTLGGV 383
Cdd:pfam05977 288 LLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTtlnVAVQLSVPRWVRGR--ALAVYQTVFFGGMAAGSWLWGA 365
|
....*.
gi 490280368 384 FWHHYG 389
Cdd:pfam05977 366 VAEALS 371
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
83-360 |
2.66e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 42.75 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 83 MLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGI--------LIMRALIGLSLSGVAAVGMTYLSEEIH 154
Cdd:cd17368 52 MRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 155 P-------SFVAFSMGLyisGNSIGGMSGRLLTGVFT----DFFGWRVALAAisgFALAAAIMFW--RILPESRHFRPTS 221
Cdd:cd17368 132 PgrrgfytSWQSASQQV---AIVAGALVGYLLSLTLTaealAEWGWRIPFFI---GLLIIPLGLWlrRSLEETEAFLERK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 222 LRPKT--LLINFRLHWRDRGLPLLFVEGfLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLsVAYLTGTWSSPKAGAMTV 299
Cdd:cd17368 206 ARPTRreLFALLANNRRIILLGMLLVAG-STVTFYFTTVYTPTYAKTVLGLSARDSFLVTL-LAGVANFIWAPLGGALSD 283
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490280368 300 RFGRGPVMLgftaVMLCGLLLTLFSSLWLIF----IGMLL--------FSAGFFAAHSVASSWIGPRARRARG 360
Cdd:cd17368 284 RIGRRPVLL----VITLAALVTLYPVFAWLTaapsFGRLLlvllvlsfFFGMYGGAMVVALVELFPVRVRSTG 352
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
59-393 |
2.95e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.65 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 59 LPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSL 138
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 139 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFWRILPEsrhfr 218
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 219 ptslRPKTLLInfrlhwrdRGLPLLFVegFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAYLTGTWSSPKAGAMT 298
Cdd:cd17312 181 ----SPPYVWV--------LSLAYAFV--YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 299 VRFGRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFAAHSV------ASSWIGPraRRARGQASSLYLFSYYL 372
Cdd:cd17312 247 FGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPInliggaAAQDIGR--KEAAGTATGFVGLFGYL 324
|
330 340
....*....|....*....|.
gi 490280368 373 GSSLAGTLGGVFWHHYGWNGV 393
Cdd:cd17312 325 GASLAGLPLGYIIDHYGWSTV 345
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
85-215 |
3.30e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.56 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 85 AVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFvafsMGL 164
Cdd:cd17315 48 AIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI----RGA 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490280368 165 YISGNSIGGMSGRLLTGVFTDFF------GWRVALAAISGFALAAAIMfWRILPESR 215
Cdd:cd17315 124 LGTLNQLMITFGILLAYLLGLALslsppgWWRLMFALAAVPALLQLLL-MFFLPESR 179
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-208 |
3.57e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 3.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 28 KRGTPQFMRVTLALFSAGLATFALLYC-VQPILPVLSNEFGVSPASSSISLSISTAMLAvgLLFTGPLSDAIGRKPVMVT 106
Cdd:cd17489 185 TRAFRRLVEKKVLPPALILFLASIAYGaISTFLPLYAAERGISNAGLFFTVYAIALLLS--RPFSGKLSDRKGPKTVIIP 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 107 ALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDF 186
Cdd:cd17489 263 GLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL 342
|
170 180
....*....|....*....|..
gi 490280368 187 FGWRVALAAISGFALAAAIMFW 208
Cdd:cd17489 343 FGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
247-393 |
6.24e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 6.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 247 GFLLMGAFVTLFNYIGYRLMMSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRFGRGPVML-GFTAVMLCGLLLTLFS 324
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLiGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 325 SLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYGWNGV 393
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-208 |
1.09e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 36 RVTLALFSAGLATFALLYCVQPIL-PVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACC 114
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEeIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|....
gi 490280368 195 AISGFALAAAIMFW 208
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-210 |
1.19e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 36 RVTLALFSAGLATFALLYCVQPILP-VLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDA-IGRKPVMVTALLLAAC 113
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 114 CSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVAL 193
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 490280368 194 AAISGFALAAAIMFWRI 210
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
156-382 |
1.39e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 156 SFVAFSMGLYISGNSIGGMSGRLLTGVFTD---FFGWRVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTLLINFR 232
Cdd:cd17332 136 SLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 233 LHWRDRGLPLLFVEGFLLMGAFVTLFNYIGY---RLMMSPWSLSQAVVGLLSVAYLTGTWSSPKagamTVRFGRGPVMLG 309
Cdd:cd17332 216 ALLKNRPFLILLLAYLLYFLAFNIVNTVLVYyfkYVLGGRAELVLLLLLILSGALLALLPWPPL----KKRFGKKKAFFI 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 310 FTAVMLCGLLLTLF---SSLWLIFIGMLLFSAGFFAAHSVASSWIG--------PRARRARGQASSLYLFSYYLGSSLAG 378
Cdd:cd17332 292 GLLLAILGLLLLFFlppGNLVLILVLAVLAGIGYGGANLLPWAMLAdvidygelKTGKRREGIFYSVMTFFRKLGLALAG 371
|
....
gi 490280368 379 TLGG 382
Cdd:cd17332 372 ALVG 375
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
82-208 |
2.13e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 39.97 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 82 AMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFS 161
Cdd:cd17374 46 AGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALA 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 490280368 162 MGLYISGNSIGGMsgrLLTGVFTDFFGWRVALAAISGFALAAAIMFW 208
Cdd:cd17374 126 ITLTSCFFSIGQM---LLAGLAYAIRDWRLLQLVVSVPFFLFFLYSW 169
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
60-221 |
2.19e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.95 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 60 PVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLS 139
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 140 GVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALaAISGFA-LAAAIMFWRILPESRHFR 218
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF-YVGGVGpLLLVPLLMRWLPESRAFA 197
|
...
gi 490280368 219 PTS 221
Cdd:PRK11551 198 QAA 200
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-208 |
2.43e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 40 ALFSAGLATFallycvqpiLPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTaLLLAACCSLLST 119
Cdd:cd17478 208 SWVLSSLTTF---------LPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIA-SLLLAAPFLLLF 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 120 MMTSWHGILIMRALIGLSLSGVAAVGMTYlSEEIHPSFVAFSMGLYIS-GNSIGGMsGRLLTGVFTDFFGWRVALAAISG 198
Cdd:cd17478 278 LLTPGIWSYILLVLAGFLLFASFPVTVVL-AQELLPGNVGLASGLMMGlSFGLGGI-GAPVLGALADAFGLESVLLILAL 355
|
170
....*....|
gi 490280368 199 FALAAAIMFW 208
Cdd:cd17478 356 LPLLGALLAF 365
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
85-217 |
2.53e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 85 AVGLLFTGPLSDAIGRKPVMVTALLLAA---CCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFS 161
Cdd:pfam00083 60 FIGSLFAGKLGDRFGRKKSLLIANVLFVigaVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGAL 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490280368 162 MGLYISGNSIGGMSGR---LLTGVFTDFFGWRV--ALAAISGFALAAAIMFWrilPESRHF 217
Cdd:pfam00083 140 GSLYQLAITFGILLAYifgLGLNKTSNSDGWRIplGLQLVPALLLIIGLLFL---PESPRW 197
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
35-210 |
2.96e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 35 MRVTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACC 114
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 490280368 195 AISGFALAAAIMFWRI 210
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
89-208 |
4.25e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.07 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 89 LFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIhPSFVAFSMGLYISG 168
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNA 331
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 490280368 169 NSIGGMSGRLLTGVFTDFFGWRVALAAISGFALAAAIMFW 208
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-210 |
4.67e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 32 PQFMRVTLALFSAGLATFALLYCVQPILpvlSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIG----RKPVMVTA 107
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYL---KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 108 LLLAACCSLLSTMMTSWHGILIMrALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFF 187
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILL-SLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAT 334
|
170 180
....*....|....*....|....
gi 490280368 188 G-WRVALAAISGFALAAAIMFWRI 210
Cdd:cd17319 335 GsYTAAFLFLAAVALLAALLVLLL 358
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
303-392 |
5.18e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 303 RGPVMLGFTAVMLCGLLL-TLFSSLWLIFIGMLLFSAGFF-----AAHSVASSWIGPRarRARGQASSLYLFSYYLGSSL 376
Cdd:TIGR00881 284 RGPLAVFFMALIIVSLLVyWLNPAANPLMDLICLFALGFLvygpqMLIGVIASELAPK--KAAGTAAGFVGFFAYLGGIL 361
|
90
....*....|....*.
gi 490280368 377 AGTLGGVFWHHYGWNG 392
Cdd:TIGR00881 362 AGLPLGYLADGFGWAG 377
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
86-193 |
6.18e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 38.76 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 86 VGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLY 165
Cdd:PRK12307 68 FGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL 147
|
90 100
....*....|....*....|....*...
gi 490280368 166 ISGNSIGGMSGRLLTGVFTDFFGWRVAL 193
Cdd:PRK12307 148 VSGFGIGNIIAAYFMPSFAEAYGWRAAF 175
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-208 |
6.38e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 29 RGTPQFMRVTLALFSAGLATFALLYcvqPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSD-AIGRKPVMVTA 107
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFST---LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 108 LLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTD-F 186
Cdd:cd06174 277 LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaT 356
|
170 180
....*....|....*....|..
gi 490280368 187 FGWRVALAAISGFALAAAIMFW 208
Cdd:cd06174 357 FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
86-211 |
8.10e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 38.22 E-value: 8.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 86 VGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSmgly 165
Cdd:cd17377 54 IGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALA---- 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 490280368 166 isgNSIGGMsgrlltgvftdFFGWRVALAAISGFalaaAIMFWRIL 211
Cdd:cd17377 130 ---GSLGGL-----------FFAVGIAQYALLGY----FIRSWRTL 157
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-208 |
9.07e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 9.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 35 MRVTLALFSAGLATFALLycvqpILpvLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACC 114
Cdd:cd17370 205 YLLAVALFALGNFSFAFL-----IL--RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 115 SLLSTMMTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRVALA 194
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|....
gi 490280368 195 AISGFALAAAIMFW 208
Cdd:cd17370 358 FSAVLALIALLLLL 371
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-215 |
9.07e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 37.99 E-value: 9.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 41 LFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSLLSTM 120
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 121 MTSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFF-GWRVALAAISGF 199
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL 163
|
170
....*....|....*.
gi 490280368 200 ALAAAIMFWRILPESR 215
Cdd:cd17328 164 GVLLAILLLLFVREPP 179
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
37-346 |
9.86e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 37 VTLALFSAGLATFALLYCVQPILPVLSNEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKPVMVTALLLAACCSL 116
Cdd:cd17352 4 VVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 117 LSTMMTS-WHGILIMRALIGLSLsgvaavGMTYLseeihPSFVAFS----------MGLYISGNSIGGMSGRLLTGVFTD 185
Cdd:cd17352 84 LSSFATSlWQLYLTYGVLGGLGL------GLIYS-----PAIVIVGqyfekkrglaTGIAVAGSGVGTFVFPPLLRYLLD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 186 FFGWRVALAAISGFALAAAIMfwrilpesrhfrptslrpkTLLINFrlhWRDRGLPLLFVEGFLLMGAFVTLFNYIGYRL 265
Cdd:cd17352 153 NYGWRGALLILGGLCLNLCVC-------------------GLLLRL---LKDPTFVLLALGVSFAMLGFFVPFVYLPSYA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 266 MMSPWSLSQAVVgLLSVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTL------FSSLWLIFIGMLLFSAG 339
Cdd:cd17352 211 KSLGIDESDAAF-LLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAfplattYVGLIVFSVLFGFCSGS 289
|
....*..
gi 490280368 340 FFAAHSV 346
Cdd:cd17352 290 YSSLTPV 296
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
39-389 |
9.88e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 9.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 39 LALFSAGLATFALLycvqPILPV-LSNEFGVSPASSSISLSIsTAMLAVGL-LFTGPLSDAIG-RKPVMVTALLLAACCS 115
Cdd:cd17471 3 LATLLTGLAGAFVL----PYLSLfLTEELGASPLQIGIFMTL-SALSGIVVsQWLGRLSDRGGdRKPLILLALLAGALGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 116 LLSTMMTSWHGILImralIGLSLSGVAAVGMTYL-------SEEIHPSFVAFSMGLYISGNSIGGMSGRLLTGVFTDFFG 188
Cdd:cd17471 78 LLFAFLRNYWVLLL----VGVVLLSLGAAAFPQLfalareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 189 WRVALAAISGFALAAAIMFWRILPESRHFRPTSLRPKTllinfRLHWRDRGLPLLFVEGFLLMGAFVTLFN-----YIGY 263
Cdd:cd17471 154 FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASS-----LVKAPVNRRLLLLFAAFTLLFAANSMYIiamplYVTN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280368 264 RLMMSPWslsqaVVGLL-SVAYLTGTWSSPKAGAMTVRFGRGPVMLGFTAVMLCGLLLTLFSSLWLIFIGMLLFSAGFFA 342
Cdd:cd17471 229 ELGGSES-----WVGLLfGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490280368 343 AHS-VASSWIGPRARRARGQASSLYLFSYYLGSSLAGTLGGVFWHHYG 389
Cdd:cd17471 304 ITAgLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFG 351
|
|
| |
