|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-416 |
4.38e-105 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 315.66 E-value: 4.38e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 91 ATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTF 170
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 171 LIIGSVGILWVIAWYFIyaenpeehkrispsevriirdgqkqhhgdktvlpmkwykllrYRNIWAMCIGFFTINYTSYFF 250
Cdd:cd17319 161 IIEGLLGLLLAVLWWFY------------------------------------------LRQVWGLALGYFGINYALYGL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 251 ITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKkvlsltATRKLFLTIGLLMALCIGFAPFTDSVF 330
Cdd:cd17319 199 LTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 331 MTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGI 410
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAA 352
|
....*.
gi 490283926 411 INYLFL 416
Cdd:cd17319 353 LLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-417 |
6.21e-94 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 288.47 E-value: 6.21e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 20 LAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVAT 99
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 100 GFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGIL 179
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 180 WVIAWYFIYAENPEEHKRISPSEVRIIRDG---QKQHHGDKTVLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPT 256
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGllaEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 257 YLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDrLVHKKVLSLTATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLL 336
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSD-LLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 337 CVAKSGtTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:TIGR00893 320 ALGFFG-LGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
.
gi 490283926 417 M 417
Cdd:TIGR00893 399 V 399
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-421 |
2.31e-81 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 255.18 E-value: 2.31e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 7 TTRIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVA 86
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 87 WWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDW 166
Cdd:COG2271 84 LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 167 RLTFLIIGSVGILWVIAwyfiyaenpeehkrispsevriirdgqkqhhgdktvlpmkwykllryrNIWAMCIGFFTINYT 246
Cdd:COG2271 164 RAAFLILGLPGLLLALL------------------------------------------------RFWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 247 SYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKvlsltatRKLFLTIGLLMALCIGFAPFT 326
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR-------KLVLAIGLLLAALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 327 DSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILV 406
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALA 347
|
410
....*....|....*
gi 490283926 407 VIGIINYLFLMGKIE 421
Cdd:COG2271 348 LLAALLALLLLRETR 362
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
16-415 |
5.89e-73 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 233.22 E-value: 5.89e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 16 GLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMM 95
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 96 GVA--TGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLII 173
Cdd:cd17380 82 PLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 174 GSVGILWVIAWYFIYAEnpeehkrispsevriirdgqkqhhgdktvlpmkwykllryrnIWAMCIGFFTINYTSYFFITW 253
Cdd:cd17380 162 GLLGLLWALVWLIYLPP------------------------------------------VWAIIVAHFCMNWGFYILLSW 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 254 LPTYLvKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVlSLTATRKLFLTIGLL-MALCIGFAPFTDSVFMT 332
Cdd:cd17380 200 LPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLgPALFLLLLSHTDSFSLA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 333 VFLLCVAKSGTTVAASQVWALPGDVAPKNSvSIVAGLQNTVSNMGGAVGPIITGAIVAATGSfnWALIF--SAILVVIGI 410
Cdd:cd17380 278 LLCMSVALGLSAFSSSGVLVNHQDIAPNYA-GIVFGISNTAGTIPGIVGVYLTGYILEATGS--WSLVFvlAAVVNLVGA 354
|
....*
gi 490283926 411 INYLF 415
Cdd:cd17380 355 VVFLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-422 |
1.24e-59 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 199.72 E-value: 1.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 9 RIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWW 88
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 89 SIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRL 168
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 169 TFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEVRIIRdgqkqhhgdktvlpmkwyKLLRYRNIWAMCIGFFTINYTSY 248
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQL------------------EALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 249 FFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVlsltatrkLFLTIGLLMALCIGFAPFTDS 328
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV--------LLIVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 329 VFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVI 408
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374
|
410
....*....|....
gi 490283926 409 GIINYLFLMGKIEP 422
Cdd:COG2223 375 ALVLTLLLYRRPRR 388
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
15-416 |
7.84e-56 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 189.37 E-value: 7.84e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 15 AGLMWLAIAINYIDRTVLSAA----------------------APHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFA 72
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAivamvnstathdnnntstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 73 DRFGQKKGLGLAVAWWSIATSMMGVAT--GFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGG 150
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 151 AIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFiyaenpeehkrispsevriirdgqkqhhgdkTVLPMkwykllry 230
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF-------------------------------LVLPV-------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 231 rniWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATRKLFL 310
Cdd:cd17318 202 ---WAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFT 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 311 TIGLL----MALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALpgDVAPkNSVSIVAGLQNTVSNMGGAVGPIITG 386
Cdd:cd17318 279 SIGFLgpgvFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHL--DLAP-NYAGTLMGITNTAATIAGIISPLIVG 355
|
410 420 430
....*....|....*....|....*....|...
gi 490283926 387 AIVA-ATGSFNWALIF--SAILVVIGIINYLFL 416
Cdd:cd17318 356 AIVKnDQTIGQWRIVFfiSAAIYILGAIFYLIF 388
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-401 |
1.96e-43 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 156.38 E-value: 1.96e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 19 WLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVA 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 99 TGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLI-VWMIYTFDWRLTFLIIGSVG 177
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVlFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 178 ILWVIAWYFIYAENPEEHKRISPSEVRI--IRDGQKQHHGDKTVLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLP 255
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNeePDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 256 TYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATRKLFLTIGLLMALCIgfaPFTDSVFMTVFL 335
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLN---PAANPLMDLICL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490283926 336 LCVAKSGtTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAAtgsFNWALIF 401
Cdd:TIGR00881 318 FALGFLV-YGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADG---FGWAGAF 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-380 |
2.42e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 2.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 7 TTRIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVA 86
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 87 WWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDW 166
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 167 RLTFLIIGSVGIL-WVIAWYFIYAENPEEHKRISPSEVRiirdgqkqhhgdktvlpmkwykLLRYRNIWAMCIGFFTINY 245
Cdd:COG2814 164 RWVFLVNAVLALLaLLLLLRLLPESRPAARARLRGSLRE----------------------LLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 246 TSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltATRKLFLTIGLLMALCIGFAPF 325
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLAL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 326 TDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAV 380
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-382 |
4.95e-39 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 143.71 E-value: 4.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 18 MWLAIAINYIDRTVLSAAAP-HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMG 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 97 VATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSV 176
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 177 GILWVIAWYFIyaENPEEHKRISPSEvriirdgqkqhhGDKTVLPMKWYKLLRYRNIWAMcIGFFTINYTSYFFITWLPT 256
Cdd:pfam07690 161 SLLAAVLLLLP--RPPPESKRPKPAE------------EARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 257 YlVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLsltatrKLFLTIGLLMALCIGFAPFTDSVFMTVFLL 336
Cdd:pfam07690 226 Y-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL------LLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490283926 337 CVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGP 382
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-411 |
2.94e-37 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 139.87 E-value: 2.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 18 MWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGV 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 98 ATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIY--TFDWRLTFLIIGS 175
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 176 VGILWVIAWYFIYAENPEEHKrispsevriiRDGQKQHHGDKTVLPMkwyKLLRYRNIWAMCIGFFTINYTSYFFITWLP 255
Cdd:cd06174 161 LALLAAILLLLVVPDPPESAR----------AKNEEASSKSVLKLLK---RVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 256 TYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRlvhkkvlsLTATRKLFLTIGLLMALCIGFAPFTDSVFMTVFL 335
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR--------LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490283926 336 LCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-415 |
1.08e-36 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 139.88 E-value: 1.08e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 47 PEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVAT--GFKSLLALRLALGVGEAAAYPSNAG 124
Cdd:TIGR00894 75 GALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAggGIALVVFCRVIQGLAQGSVSPATHK 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 125 IAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMI-YTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEV 203
Cdd:TIGR00894 155 IIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEK 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 204 RII-RDGQKQHHGDKTVLPMKwyKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMV 282
Cdd:TIGR00894 235 KYInSSLQGQKGSTRQSLPIK--AIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 283 IEVFAGWASDRLVHKKVLSLTATRKLFLTIG-LLMALCIGFAPFTDSVF-MTVFLLCVAKSGTTVAASQVWALPGDVAPK 360
Cdd:TIGR00894 313 CSIFAGYLADFLKSSKTLSLTAARKIFNGIGgLGPGIFAYALPYLSAAFyLTIIILTLANAVSSGPLAGVLINSLDLAPR 392
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 361 NSVsIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFsAILVVIGIINYLF 415
Cdd:TIGR00894 393 FLG-FIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVF-LIMAFVNILCVIF 445
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
33-413 |
6.09e-36 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 136.45 E-value: 6.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 33 SAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVAT--GFKSLLALRLA 110
Cdd:cd17381 50 SVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAAdlGAGYLIAVRAL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 111 LGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIyae 190
Cdd:cd17381 130 EGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWL--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 191 npeehkrispsevriirdgqkqhhgdktVLPMkwykllryrniWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMG 270
Cdd:cd17381 207 ----------------------------VMPL-----------WAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 271 MVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATRKLFLTIGLL----MALCIGFAPFTDSVFMTVFLLCVAKSGTTVA 346
Cdd:cd17381 248 FLSALPYLGCWLFMILSGQIADNLREKQNFSTVCVRKIFTLIGMIgpavFLLAAGFTGCNYSLAVAFLTISSTLGGFSAS 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490283926 347 ASQVWALpgDVAPKNSvSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIF--SAILVVIGIINY 413
Cdd:cd17381 328 GFNINHL--DIAPSYA-GILLGITNTFATIPGMVGPVIAKSLTHNNTVEEWQTVFyiSAAINVFGAIFF 393
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
37-416 |
1.39e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 132.31 E-value: 1.39e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 37 PHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEA 116
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 117 AAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHK 196
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 197 RISPSEVRIIRdgqkqhhgdktvlpmKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALP 276
Cdd:cd17325 180 KRAVSAARLRS---------------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 277 LLCGMVIEVFAGWASDRLvhkkvlsltaTRKLFLTIGL-LMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPG 355
Cdd:cd17325 245 GLASALSQPPAGKLSDRI----------GRKPLILIGLlLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490283926 356 DVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIvAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL-YDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
46-416 |
6.69e-33 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 127.84 E-value: 6.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 46 DPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVAT--GFKSLLALRLALGVGEAAAYPSNA 123
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAArvHYGCVIFVRILQGLVEGVTYPACH 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 124 GIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIyaenpeehkrispsev 203
Cdd:cd17382 127 GIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV---------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 204 riirdgqkqhhgdktVLPmkwykllryrnIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVI 283
Cdd:cd17382 191 ---------------SMP-----------VYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTII 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 284 EVFAGWASDRLVHKKVLSLTATRKLFLTIGLLMA----LCIGFAPfTDSVFMTVFLLCVAKSGTTVAASQVWALpgDVAP 359
Cdd:cd17382 245 VPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEatflLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHL--DIAP 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490283926 360 KNSvSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFS-AILVVI-GIINYLFL 416
Cdd:cd17382 322 RYA-SILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLiASLVHFfGVIFYAIF 379
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-411 |
1.32e-31 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 124.27 E-value: 1.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 18 MWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGV 97
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 98 ATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVG 177
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 178 ILWVIAWYFIYAENPEehkrispsevrIIRDGQKQHHGDKTVLPMkwyklLRYRNIWAMCIGFFTINYTSYFFITWLPTY 257
Cdd:cd17475 161 ILAAVLFWLFYREPPA-----------ASAATESASTLLRSLKEV-----LRNRDVWLIAIAGALLVAPQFALLTFLLLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 258 LVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLV---HKKVLSLTAtrklflTIGLLMALCIGFAPFTdSVFMTVF 334
Cdd:cd17475 225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITA------AIAAAALLVLSLLSPG-TPLWLLV 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 335 LLCVAKSGTTVAASQVW-ALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17475 298 LLLILLGLFAIGWNGLYlTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-411 |
2.05e-31 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 124.22 E-value: 2.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 1 MNTTANTTRIRWWIAGLMWLA----IAINYidRTVLSAAAP---HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFAD 73
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLaivlVALNL--RPAITSVGPllpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 74 RFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKeRATVSGLFDSASKFGGAIA 153
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 154 MPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRiSPSEVRIIRdgqkqhhgdktvlpmkwykLLRYRNI 233
Cdd:COG2807 158 AGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA-APAAASLRS-------------------LWRSPLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 234 WAMCIGFFTINYTSYFFITWLPTYLVkEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLtatrkLFLTIG 313
Cdd:COG2807 218 WLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL-----LLGLLG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 314 LLMALCIGFAPfTDSVFMTVFLLCVAKSGTTVAAsqvWALPGDVAP-KNSVSIVAGLQNTVSNMGGAVGPIITGAIVAAT 392
Cdd:COG2807 292 LAGLLGLLLAP-GSLPWLWAVLLGLGQGGLFPLA---LTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT 367
|
410
....*....|....*....
gi 490283926 393 GSFNWALIFSAILVVIGII 411
Cdd:COG2807 368 GSWTAALLLLAALAVLMLV 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-388 |
6.96e-31 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 122.73 E-value: 6.96e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 16 GLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMM 95
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 96 GVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMI-YTFDWRLTFLIIG 174
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 175 SVGILWVIAWYFIYAENPeehkrispsevRIIRDGQKQHHGDKTVLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWL 254
Cdd:cd17328 162 VLGVLLAILLLLFVREPP-----------RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 255 PTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATRKLFLTIGLLMAL-CIGFAPFTDSVFMTV 333
Cdd:cd17328 231 PTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAApFLFLALVLALSNLLL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490283926 334 FLLCVAksGTTVAASQVWALPGD-----VAPKNSVSIVAgLQNTVSNM-GGAVGPIITGAI 388
Cdd:cd17328 311 AWVLLF--LGEFLLSLNWAPVFAillyvVIPTRRSTASA-IQILLSHLlGDAGSPYLIGLI 368
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
11-408 |
2.40e-29 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 117.76 E-value: 2.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 91 ATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTF 170
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 171 LIIGSVGILWVIAWYFIYAENPeehkrispsevriirdgqkqhhgdktvlpmkwykllryRNIWAMCIGFFTINYTSYFF 250
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------------------------------PYVWVLSLAYAFVYIVRYAC 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 251 ITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLtatrkLFLTIGLLMALCIGFAPFTDSVF 330
Cdd:cd17312 203 LDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPI-----AVIYMLLMTLSLALFWFFPHNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 331 MTVFLLCVAksGTTVAASQVW---ALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFN--WALIFSAIL 405
Cdd:cd17312 278 LSIVLLFLI--GFFVGGPINLiggAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTvfYFLISAALL 355
|
...
gi 490283926 406 VVI 408
Cdd:cd17312 356 SVL 358
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
30-416 |
1.24e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 113.05 E-value: 1.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 30 TVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRL 109
Cdd:cd17474 16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 110 ALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAmPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYA 189
Cdd:cd17474 96 LQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 190 ENPEEHKRISPSEVRIIRdgqkqhhgdktvlpmkwyKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKM 269
Cdd:cd17474 175 EPKEKAKSSSATKLRDLK------------------KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 270 GMVAALPLLCGMVIEVFAGwasdRLVHKKVLSltatRKLFLTIGLLMALCIGFAPFTDSvfMTVFLLCVAKSGTTVAASQ 349
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVG----RLLKKRFGA----RRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490283926 350 --VWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGaIVAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:cd17474 307 plLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG-LLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-411 |
2.12e-27 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 112.73 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 9 RIRWWIAGLMWLAIAINYIDRTVLS-AAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAW 87
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISnAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 88 WSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAmPLIVWMIYTFD-- 165
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFKILgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 166 -----WRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEVRIIRDGQKQHHGDKTVLPMKWYK----LLRYRnIWAM 236
Cdd:cd17327 160 gglagWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQikeaFKDPR-TWLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 237 CIGFFTINYTSYFFITWLPTyLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATrkLFLTIGLLM 316
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFAC--VLALVGSII 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 317 alcIGFAPFTDSVFMTVFLLCVAkSGTTVAASQVWAlPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIItgAIVAATGSFN 396
Cdd:cd17327 316 ---LLAAPNPPGAYFAAYILGGG-SYAGFPILLSWI-SSNCAGYTKRATVLAIMLIFYNVGNIVAPQI--FRAGDAPRYI 388
|
410
....*....|....*
gi 490283926 397 WALIFSAILVVIGII 411
Cdd:cd17327 389 PGNIALLVCACVSIV 403
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-386 |
6.41e-25 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 105.52 E-value: 6.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 3 TTANTTRIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLG 82
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 83 LAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIY 162
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 163 TFDWRLTFLI--IGSVGILWVIAWY------FIYAENPEEHKRISPSEVRIIRDGQKQHHGDKTVLPMKW---YKLL--- 228
Cdd:TIGR00895 167 VFGWRSLFYVggIAPLLLLLLLMRFlpesidFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKrsvFKALfqg 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 229 -RYRNIWAMCIGFFTINYTSYFFITWLPtYLVKEKGMDFIKMGMVAALpLLCGMVI-EVFAGWASDRLVHKKVLSltatr 306
Cdd:TIGR00895 247 kTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGAL-FNFGGVIgSIIFGWLADRLGPRVTAL----- 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 307 kLFLTIGLLmaLCIGFAPFTDSVFMTVFLLCVaksGTTVAASQVwALPGDVAPKNSVSIVAGLQNTVSNMG---GAVGPI 383
Cdd:TIGR00895 320 -LLLLGAVF--AVLVGSTLFSPTLLLLLGAIA---GFFVNGGQS-GLYALMALFYPTAIRATGVGWAIGIGrlgAIIGPI 392
|
...
gi 490283926 384 ITG 386
Cdd:TIGR00895 393 LAG 395
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-411 |
1.17e-24 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 104.56 E-value: 1.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 31 VLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLA 110
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 111 LGVGEAAAYPSNAGIAARwFPDKERATVSGLFDSASKFGGAIAmPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFiyae 190
Cdd:cd17478 94 AGIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALG-PLIAAALVALFGGLGLLILLIIPGLAVALLLL---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 191 npeehkRISPSEVRIIRDGQKQHHGDKTVLPMkwykllrYRNIWAMCIGFFTINYTSYFFITWLPTYLVkEKGMDFIKMG 270
Cdd:cd17478 168 ------RLRPLKKPEAKKAAAKSSARSTLKGV-------WRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 271 MVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTAtrklfltigLLMALCIGFAPFTDSVFMTVFLLCV-AKSGTTVAASQ 349
Cdd:cd17478 234 LLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL---------LLAAPFLLLFLLTPGIWSYILLVLAgFLLFASFPVTV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490283926 350 VWAlpGDVAPkNSVSIVAGLQNTVSNMGGAVGPIITGAIvAATGSFNWALIFSAILVVIGII 411
Cdd:cd17478 305 VLA--QELLP-GNVGLASGLMMGLSFGLGGIGAPVLGAL-ADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
16-411 |
4.64e-24 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 102.28 E-value: 4.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 16 GLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMM 95
Cdd:cd17365 2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 96 GVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGS 175
Cdd:cd17365 82 AFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 176 VGILwviawyfiyaenpeehkrispsevriirdgqkqhhgdktVLPMKWYKLLryrnIWAMcigFFTINYTSYFFITWLP 255
Cdd:cd17365 162 PPLI---------------------------------------LLPLLRGTLL----LWVT---FFMGLLLVYLLNSWLP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 256 TyLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTAtrklFLTIGLLMALCIGFAPFtdsvfmTVFL 335
Cdd:cd17365 196 K-LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFF----ALGAVSLALLGVSPASL------VLLY 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 336 LCVAKSGTTVAASQV--WALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17365 265 VLVFLAGACVNGAQVglYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGAL 342
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-411 |
1.70e-23 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 101.58 E-value: 1.70e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 12 WWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIA 91
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 92 TSMMGVATGFKSLLALRLALGVGEAA--AYPSNAGIAARWFpDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLT 169
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGtlAAVAFATVAAWWF-ERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 170 FLIIGSV-GILWVIAWYFIYAENPEEHKRISpsevriirdgqkqHHGDKTVLPMKWYKLLRYRNIWAMCIGFFTINYTSY 248
Cdd:cd17355 161 LLVLALLaLLVLVPVLLLLRRRPADLALRAY-------------DDASPASPGSTLKEALRSASFWLLALAFFLCGFAVV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 249 FFITWLPTYLVkEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltATRKLFLTIGLLMALCIGFAPFTDS 328
Cdd:cd17355 228 GLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY---------SPRRLLAASYALRALGLALLLLLPF 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 329 VFMTVFLLCVAK---SGTTVAASQvwALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAIL 405
Cdd:cd17355 298 PPLALLLFAALFglgWGATVPLTA--ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVAL 375
|
....*.
gi 490283926 406 VVIGII 411
Cdd:cd17355 376 GLIAAL 381
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
4-411 |
2.03e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 101.08 E-value: 2.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 4 TANTTRIRWWIAGLMWLAIAINYidrTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGL 83
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFAT---ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 84 AVAWWSIATSMMGVATGFKSLLALRLALGVG----EAAAYPsnagIAARWFPDKERATVSgLFDSASKFGGAIAMPLIVW 159
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGlgllDVAANP----YVAALGPETAASRLN-LLHAFFSLGALLGPLLGGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 160 MI---YTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEVRIIRdgqkqhhgdktvlpmkwyKLLRYRNIWAM 236
Cdd:COG0738 154 LIllgLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK------------------SLLKNPRLLLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 237 CIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTAtrklfltigLLM 316
Cdd:COG0738 216 GLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA---------LLA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 317 ALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLqNTVSNMGGAVGPIITGAIVAATGsFN 396
Cdd:COG0738 287 AVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV-LIMGIVGGAIGPPLIGFLADAFG-LR 364
|
410
....*....|....*
gi 490283926 397 WALIFSAILVVIGII 411
Cdd:COG0738 365 AAFLVPLVCYLLILL 379
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-411 |
2.24e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 100.70 E-value: 2.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 37 PHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEA 116
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 117 AAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHK 196
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 197 RispsevriirdgqkqhhgdKTVLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALP 276
Cdd:cd17324 183 G-------------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 277 LLCGMVIEVFAGWASDRLVHKKVLSltatrkLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAkSGTTVAASQVWALpgD 356
Cdd:cd17324 244 GVAGVVGSPLAGRLADRGGRRALLI------ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLG-FFAAHSALQTRVL--R 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 357 VAPKNSvSIVAGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILVVIGII 411
Cdd:cd17324 315 LAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALL 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-411 |
1.13e-22 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 98.44 E-value: 1.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 15 AGLMWLAIAINYIDRTVLSAAAPHLIDELK--LDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIAT 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 93 SMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFD----WRL 168
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 169 TFLIigsVGILWVIAWYFiyaenpeehkrispsevriirdgqkqhhgdktvlpmkwykllrYRNIWAMCIGFFTINYTSY 248
Cdd:cd17316 161 LFLI---GALPALLALLL-------------------------------------------RRRTLLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 249 FFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSltatrkLFLTIGLLMALCIGFAPFTDS 328
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLV------IGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 329 VFMTVFLLCVAKSGTTVAASqVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVI 408
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGA-LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
...
gi 490283926 409 GII 411
Cdd:cd17316 348 ALI 350
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-187 |
2.05e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 96.80 E-value: 2.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 2 NTTANTTRIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGL 81
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 82 GLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMI 161
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180
....*....|....*....|....*.
gi 490283926 162 YTFDWRLTFLIIGSVGILWVIAWYFI 187
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
26-417 |
5.28e-22 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 97.31 E-value: 5.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 26 YIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKK----GLGLAVAWWSIATSMMGVATGF 101
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRflaiGLILSAIINILIGFVPSATSSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 102 KSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTF---DWRLTFLIIGSVGI 178
Cdd:cd17345 96 GLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 179 LWVIAWYFIYAENPEEhKRISPSEVrIIRDGQKQHHGDKTVLPM-KWYKLLRY----RNIWAMCIGFFTINYTSYFFITW 253
Cdd:cd17345 176 IVAVIVLFLGKDTPES-EGLPPIEE-YKGDYPEEADGEEEEQELsAWEIFVKYvlknKLLWYIAIANVFVYLVRYGILDW 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 254 LPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKvLSLTATRKLFLTIGLLMAlcigfapFTDSVFMTV 333
Cdd:cd17345 254 APTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGR-RAPTGIIFMILVIVALIV-------YWLAPNVLV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 334 FLLCVAKSGTTVAASQ----VWALpgDVAPKNSVSIVAGLQNTVSNMGGAV-GPIITGAIVAATGsFNWALIFSAILVVI 408
Cdd:cd17345 326 DLIALIALGFLIYGPVmligLQAL--ELVPKKAAGTAAGLTGLFGYLGGSVlATALIGIIVDHFG-WNGGFIVLLASCIL 402
|
....*....
gi 490283926 409 GIINYLFLM 417
Cdd:cd17345 403 AIIFLALVA 411
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
68-416 |
7.86e-21 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 93.41 E-value: 7.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 68 AGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASK 147
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 148 FGGAIAmPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEVRIirdgqkqhhgdktvlpmkwyKL 227
Cdd:cd17473 135 LGGVVF-LLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATA--------------------AA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 228 LRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTAtrk 307
Cdd:cd17473 194 LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF--- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 308 LFLTIGLLMalcIGFAPFTDSVFMTVFLLCVAkSGTTVAASQVWALpgDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGA 387
Cdd:cd17473 271 ALMALGFLL---LALASGLWVVLLGAILAGLG-FGLLLPTLNSWAM--SLVPPELRGRAMGIVTSAFFLGQFLSPLVLGP 344
|
330 340
....*....|....*....|....*....
gi 490283926 388 IVAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:cd17473 345 LVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-411 |
6.99e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 90.71 E-value: 6.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 30 TVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRL 109
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 110 ALGVGeAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAwyfiya 189
Cdd:cd17504 93 LQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 190 enpeehkrispsevriirdgqkqhhgdktvLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKM 269
Cdd:cd17504 166 ------------------------------VPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 270 GMVAALPLLCGMVIEVFAGWASDRLVHKkvlslTATRKLFLTIGLLMAL-CIGFAPFTDSVFMTVFLLCVAKSGTTVAAS 348
Cdd:cd17504 216 ITEAGLLLLPGALVMLIAGPLAGRLIAR-----VGPRRVLLIGLVISAVgLLLLALLHSSLWALVVALLLIGIGLGLAFA 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 349 QVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAI------------VAATGSFNWALIFSAILVVIGII 411
Cdd:cd17504 291 SLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggVPTEGAYVLAFLIGAALALAALL 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-416 |
1.58e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 89.54 E-value: 1.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 27 IDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLA 106
Cdd:cd17321 10 LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 107 LRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGIlwvIAWYF 186
Cdd:cd17321 90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL---VALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 187 IyaenpeehkrispsevriirdgqkqhhgdktvlpmkwykllryRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDf 266
Cdd:cd17321 167 A-------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYS- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 267 ikmGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVA 346
Cdd:cd17321 203 ---PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFAT 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 347 ASQVWALpgDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAA----------------------TGSFNWALIFSAI 404
Cdd:cd17321 280 PLTNAAL--SSVPKEKAGAASGILNTARQLGGALGVALLGALLTAglsanlgdsgvaallsaaaaafAAGFHLAFLVAAA 357
|
410
....*....|..
gi 490283926 405 LVVIGIINYLFL 416
Cdd:cd17321 358 LALLAALLALLL 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-417 |
2.24e-19 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 89.19 E-value: 2.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 47 PEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIA 126
Cdd:cd17489 30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 127 ARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEvrii 206
Cdd:cd17489 110 ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT---- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 207 rdGQKQHHGDKTVLPMkwykllryrniwAMCIGFFTINYTSyfFITWLPTYlVKEKGMDFIkmGMVAALPLLCGMVIEVF 286
Cdd:cd17489 186 --RAFRRLVEKKVLPP------------ALILFLASIAYGA--ISTFLPLY-AAERGISNA--GLFFTVYAIALLLSRPF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 287 AGWASDRLVHKKVLSLTAtrkLFLTIGLLMalcIGFAPfTDSVFMTVFLLCVAKSGTTVAASQVWALpgDVAPKNSVSIV 366
Cdd:cd17489 247 SGKLSDRKGPKTVIIPGL---LLLALGLLL---LSFAG-SPWMLLLAAVLYGLGFGLLFPALQALAV--DLVPPHRRGAA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490283926 367 AGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILVVIGIINYLFLM 417
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
11-416 |
3.99e-17 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 82.66 E-value: 3.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 91 ATSMMGVATgfkSLLALRLALGV----GEAAAYPSNAGIAARWFPDKeRATVSGLFDSASKFGGAIAMPLIVWMIYTFDW 166
Cdd:cd17353 81 GFILSAFAI---SLPLLFLGYGVlggiGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 167 RLTFLIIGSV-GILWVIAWYFIyaENPEEHKriSPSEVRIIRDGQKQHHGDKTVLPMkwyklLRYRNIWAMCIGFFTINY 245
Cdd:cd17353 157 PTTFLILGIIfLIIIVIGAFLI--RDPPKGW--VPPGVDPLANNAENSPRDYTPREM-----LRTPTFWLLWLMFFLNAT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 246 TSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLtatrklfltIGLLMALCIGFAPF 325
Cdd:cd17353 228 AGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI---------AFLIQGVAMFLLPF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 326 TDSVFMTvFLLCVAKSGTTVAA--SQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAiVAATGSFNWALIFSA 403
Cdd:cd17353 299 IGSVAVL-FVLGVALIGFCYGGgfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAA 376
|
410
....*....|...
gi 490283926 404 ILVVIGIINYLFL 416
Cdd:cd17353 377 ALSLVALALALLL 389
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
35-419 |
6.80e-17 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 81.93 E-value: 6.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 35 AAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVG 114
Cdd:PRK11551 37 AAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 115 EAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFlIIGSVGILWVIAwyFIYAENPEE 194
Cdd:PRK11551 117 LGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF-YVGGVGPLLLVP--LLMRWLPES 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 195 hkrispSEVRIIRDGQKQHHGDKTVLpmkwYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVkEKGMDFIKMGMVAA 274
Cdd:PRK11551 194 ------RAFAQAAGAGKQRAPVLRAL----FGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLV-GQGLSRSQAGLVQI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 275 LPLLCGMVIEVFAGWASDRLVHKKVLSLtatrklfLTIGLLMAL-CIGFAPftdsvFMTVFLLCVAKSGTTVAASQ--VW 351
Cdd:PRK11551 263 AFNIGGALGSLLIGALMDRLRPRRVVLL-------IYAGILASLaALAAAP-----SFAGMLLAGFAAGLFVVGGQsvLY 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 352 ALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGIINYLFLMGK 419
Cdd:PRK11551 331 ALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASIPVILVAALAALLLVSR 398
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-416 |
3.33e-16 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 79.93 E-value: 3.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 27 IDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLA 106
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 107 LRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAwyf 186
Cdd:cd17503 90 FRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 187 iyaenpeehkrispsevriirdgqkqhhgdktvLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDF 266
Cdd:cd17503 167 ---------------------------------APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 267 IKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltATRKLFLTIGLLMAL-CIGFAPFTD--SVFMTVFLLCV--AKS 341
Cdd:cd17503 214 FESGLVLAPGGLASAILSPLVGRLLDKF---------GPRLLLLAGLLLLALgTLLLAFLTPdtSLWLIILPLFIrgLGM 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 342 GTTVAASQVWALpGDVaPKNSVSIVAGLQNTVSNMGGAVGPIITGAIV----------------------AATGSFNWAL 399
Cdd:cd17503 285 GLVFMPLNTLAL-NSL-PPEQIGDATALFNTIRQLGGSIGTALLATLLtnrtqfhhsrlsellaqqvqkqALIIAFNDAF 362
|
410
....*....|....*..
gi 490283926 400 IFSAILVVIGIINYLFL 416
Cdd:cd17503 363 LVSAILLLVGLLLALFL 379
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-416 |
4.61e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 79.27 E-value: 4.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 19 WLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVA 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 99 TGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMI----YTFDWRLTFLiig 174
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFL--- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 175 sVGILWVIAWYFIYAENPEehkrisPSEVRiirdgQKQHHGDKTVLPMKWYKLLRYRNIWAMCIGFFT---INYTSYFFI 251
Cdd:cd17371 162 -LGALPALLVLFIRRFVKE------PPQWQ-----AARAARRHFADRPSLRELFSPPLLRTTLLASLLatgALGGYYGIT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 252 TWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSltatrkLFLTIGLLMALCIGFAPFTDSVFM 331
Cdd:cd17371 230 TWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA------LFALGSAISILLYFFLPLSPTLIL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 332 TV-----FLLCVAKSGTTVAASQVWalpgdvaPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILV 406
Cdd:cd17371 304 ILgfplgFFASGPFSGMGAYLTELF-------PTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYY 376
|
410
....*....|
gi 490283926 407 VIGIINYLFL 416
Cdd:cd17371 377 IAGLVLALLL 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
17-408 |
1.55e-15 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 77.68 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 17 LMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMG 96
Cdd:cd17341 3 LSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 97 VA-TGFKSLLALRLALGVGeAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIA---MPLIV----WMIYTFDWRL 168
Cdd:cd17341 83 LAvSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllAPLIAgaivFDGGFVGWRN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 169 TFLIIGSVGILWVIAwYFIYAENPEEHKRISPSEVRIIRDGQKQHHGdktvlpmkWYKLLRYrniwAMCIGFFTInytsy 248
Cdd:cd17341 162 AFFVPGILLAIAAVL-VLLFGDDLPTGKASALEFLKVQLAVLKNYRT--------WILSLLY----GVTFGSFVG----- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 249 fFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLtatrkLFLTIGLLMALCIgFAPFTDS 328
Cdd:cd17341 224 -FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWW-----LFIVMTIGAALLS-LSLPTSG 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 329 VFMTVFLLC--VAKSGTTVAASQVWALPGDVAPKNSvSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILV 406
Cdd:cd17341 297 TNLVLFLALfvALGLGAGAGNGSVFRMVPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLA 375
|
..
gi 490283926 407 VI 408
Cdd:cd17341 376 VA 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-188 |
4.08e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.46 E-value: 4.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 17 LMWLAIAINYIDRTVLSAAAP-HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMM 95
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 96 GVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGS 175
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
170
....*....|...
gi 490283926 176 VGILWVIAWYFIY 188
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
11-420 |
9.23e-15 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 75.45 E-value: 9.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 91 ATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTF 170
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 171 LIIGSVGILWVIAWYFIYAENPEEhkrispSEVRIIRDGQKQHHGDKTVLP-MKWYKLLRYRNIWAMCIGFFTINYTSYF 249
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSD------VGLNNIEEEESKGKKKKSPRGeSTLKELLLSPFLWLLSLGYLVVFGVKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 250 FITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATRKLFLTIGLLMALCIGFapftdsv 329
Cdd:cd17343 235 VTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSL------- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 330 fmtvFLLCVAKsgtTVAASQVW----------------ALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITG---AIVA 390
Cdd:cd17343 308 ----HLFRVHI---TSDSSELFilllgfligfslygpiAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGlpfSYIA 380
|
410 420 430
....*....|....*....|....*....|.
gi 490283926 391 AtgSFNWALIFSAILV-VIGIINYLFLMGKI 420
Cdd:cd17343 381 K--HYDWRTAFLLLEIlCAITVVILFLLRNI 409
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-417 |
1.07e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 69.18 E-value: 1.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 18 MWLAIAINYIDRTVLSAAAP----HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATS 93
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPfmaiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 94 MMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAmPLIVWMIYTFDWRLTFLII 173
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 174 GSVGILWVIAWYFIYAENPEEHKRISPSEVRIirdgqkqhhgdktvlpmKWYKLLRYRNIWAMCIGFFTINYTSYFFITW 253
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAEKTEILR-----------------GYKIVLRDRAFLLFLLASFLISLIYFQLEST 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 254 LPTYLVKekgMDFIKMGMVAALPLLCGMVIEVFAGWASdrlvhkKVLSLTATRKLFLTIGLLMALCIGFAPFTDSVFMTV 333
Cdd:cd17329 223 LPVYVVE---ILGLGESLLGLLLALNALLIVLLQFPVA------RLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 334 FLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILVVIGIINY 413
Cdd:cd17329 294 LAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALL 372
|
....
gi 490283926 414 LFLM 417
Cdd:cd17329 373 LGLQ 376
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
9-338 |
1.52e-12 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 68.97 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 9 RIRWW---IAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAV 85
Cdd:PRK11663 16 RYRYWrrhILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 86 awwsIATSMMGVATGFKSLLALRLALGVGEAA----AYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIaMPLIVWMI 161
Cdd:PRK11663 96 ----IATGIINILFGFSSSLWAFALLWVLNAFfqgwGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGAL-IPLVVGAI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 162 -YTFDWRLTFLIIGSVGILWVIAWYFIYAENPEE-------HKRISPSEVRIIRDGQKQHHgdKTVLpmKWYKLLRyRNI 233
Cdd:PRK11663 171 aLHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAmglpsvgEWRHDALELAQQQEGAGLSR--KEIL--TKYVLLN-PYI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 234 WAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVH--KKVLSLTATRKLFLT 311
Cdd:PRK11663 246 WLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNgnRGPMNLIFAAGILLS 325
|
330 340
....*....|....*....|....*..
gi 490283926 312 IGLLMALcigfaPFTDSVFMTVFLLCV 338
Cdd:PRK11663 326 VGSLWLM-----PFASYVMQAACFFTI 347
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
46-410 |
1.89e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 68.35 E-value: 1.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 46 DPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGI 125
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 126 AARWFPDKERATVSGLFDSASKFGGAIAmPLIVWMIYTFDWRLtFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEVRI 205
Cdd:cd17477 109 LNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGALP-FLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 206 irdgqkqhhgdktvlpmkwykllrYRNIWAMCIGFFTINYTSYFFITWLPTYLVkEKGMDFIKMGMVAALPLLCGMVIEV 285
Cdd:cd17477 187 ------------------------LRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQW 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 286 FAGWASDRLVHKKVLSLTATrklfltIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGT--TVAASQVwalpGDVAPKNSV 363
Cdd:cd17477 242 PLGWLADRFDRRRVLLGCAL------LGALAALLLPLVPGLPLALLVLLFLWGGAAGPlyTLALALA----GDRLPGDEL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490283926 364 SIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGI 410
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-393 |
3.28e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 3.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 4 TANTTRIRWW-IAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAF-FWSySLLQIPAGWFADRFGQKKG- 80
Cdd:COG2211 1 TAAKKKLSLKeKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVArLWD-AITDPLIGALSDRTRTRWGr 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 81 -------------LGLAVAWWSIATSMMGVATGFkslLALRLALGVGEAAAYPSNAGIAARWFPD-KERATVSGLFDSAS 146
Cdd:COG2211 80 rrpwiligaiplaLSFVLLFTAPDLSPTGKLIYA---LVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 147 KFGGAIAMPLIVWMIYTFD------WRLTFLIIGSVGILWVIAWYFiyaeNPEEHKRISPSEVRIIRDgqkqhhgdktvl 220
Cdd:COG2211 157 GLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFF----GTKERPVPEEEKVSLKES------------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 221 pmkWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvl 300
Cdd:COG2211 221 ---LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF------ 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 301 sltATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQV--WALPGDVAP-------KNSVSIVAGLQN 371
Cdd:COG2211 292 ---GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVlpWAMLADVVDydewktgRRREGLYFGIFT 368
|
410 420
....*....|....*....|..
gi 490283926 372 TVSNMGGAVGPIITGAIVAATG 393
Cdd:COG2211 369 FAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
18-416 |
1.34e-11 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 65.50 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 18 MWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVawwsIATSMMGV 97
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGL----IATGIINI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 98 ATGFKSLLALRLAL----GVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLII 173
Cdd:cd17488 84 LFGFSSSLWAFAVLwtlnAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 174 GSVGILWVIAWYFIYAENPeehkrispsevriirdgqkqhhgdktvlpmkwykllryRNIWAMCIGFFTINYTSYFFITW 253
Cdd:cd17488 164 GIIAILMGIVLCWRLRDRP--------------------------------------PYIWLLAFCYVLVYVVRTAINDW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 254 LPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHkkvlSLTATRKLFLTIGLLmaLCIGFAPFTDSVFMTV 333
Cdd:cd17488 206 GNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK----GNRGPMNLIFALGLL--VSVGALWLVPVHSYWL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 334 FLLCVAKSGTTVAASQVWALPG--DVAPKNSVSIVAGLQNTVSNMGGAVGPIitgAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17488 280 LATCFFTIGFFVFGPQMLIGMAaaECSHKDAAGSATGFVGLFAYLGAALAGY---PLAKVIESWGWSGFFIVISIAAAIS 356
|
....*
gi 490283926 412 NYLFL 416
Cdd:cd17488 357 GLLLL 361
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
52-415 |
2.79e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 64.59 E-value: 2.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 52 FIMAAFF---WsysllqipaGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAAR 128
Cdd:cd17391 46 FLVSAIFspiW---------GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 129 WFPDKERATVSGLfdSASKFGGAIAMPLIVWMIY-TFDWRLTFLIIGSVGILWVIAWYFIYAEN---PEEHKRISPSEVr 204
Cdd:cd17391 117 TPKEKSGWALGTL--STGVVAGTLIGPLLGGFLAdLFGIRNVFFITGGLLFLAFLLTLFFVKEDfkpVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 205 iirdgqkqhhgdktvlpmkWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYL----VKEKGMDFIKmGMVAALPLLCG 280
Cdd:cd17391 194 -------------------WNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIrqlmGDASNLAFIS-GLVFSATGVSS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 281 MVIEVFAGWASDRLVHKKVLsltatrklfltiglLMALCIGFAPFTDSVFMTV--------FLLCVAKSGTTVAASqvwA 352
Cdd:cd17391 254 LLSAPRLGKLGDRIGHHRIL--------------LGALLASALLYIPQAFVQTpwqlgilrFLLGLATGGLLPAIN---S 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490283926 353 LPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIItGAIVAATGSFNWALIFSAILVVIGIINYLF 415
Cdd:cd17391 317 LLAKITPKEVAGRIFGYNQSFQYLGNVAGPLL-GSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
13-411 |
5.24e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.75 E-value: 5.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 13 WIAGLMWlaiAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIAT 92
Cdd:cd17320 2 LLLALLV---ALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 93 SMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLI 172
Cdd:cd17320 79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 173 IGSVGILwVIAWYFIYAENPEEHKRISPSEVRIIRDgqkqhhgdktvlpmkWYKLLRYRNIW--AMCIGFFTINYTSYFF 250
Cdd:cd17320 159 LALLGLL-LLLLVLLFLPETLPEEKRKPLLSSLLRA---------------YKRVLKNRRFLgyALALGLSFAGLFAYLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 251 ITwlPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATrkLFLTIGLLMALCIGFAPFTDSVF 330
Cdd:cd17320 223 AA--PFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLL--LLLAAALVLLLAALLGGLSLWPL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 331 MTVFLLCVAKSGTTVAASQVWALpgdVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAAT-GSFNWALIFSAILVVIG 409
Cdd:cd17320 299 VAPLFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTaLPMGLLILVLGLLALLL 375
|
..
gi 490283926 410 II 411
Cdd:cd17320 376 LI 377
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-416 |
5.49e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 63.74 E-value: 5.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 19 WLAIAINYIDRTVLSAAAPHLIDELKlDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVA 98
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 99 TGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFgGAIAMPLI-VWMIYTFDWRLTFLIigsvg 177
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGI-ASVAGPLIgGAFTDHLSWRWCFYI----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 178 ilwviawyfiyaeNpeehkrispsevriirdgqkqhhgdktvLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTY 257
Cdd:cd17502 155 -------------N----------------------------LPIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 258 LVKEKGMDFIKMGmVAALPLLCGMVIEVF-AGWASDRLVHKKVLSLTATrkLFLTIG-LLMALCIGFAPFtdSVFMTVFL 335
Cdd:cd17502 194 FQLVLGDSATKSG-VRLLPLIIGLVIGSIiSGALISKTGRYKPLIVIGT--ILMSVGaGLLTTLTLDTSK--WLLIGYLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 336 LCVAKSGTTVAASQVWALpgDVAPKNSVSIVAGLQNTVSNMGGAVGpiitgaivaatGSFNWALIFSAILVVIGIINYLF 415
Cdd:cd17502 269 LLGLGLGIGFQQPLVAVQ--NAVPPADVGVATATNTFFRSLGGTLG-----------VAITDVFLVALALAALAFLLSLF 335
|
.
gi 490283926 416 L 416
Cdd:cd17502 336 L 336
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
15-198 |
5.83e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 64.32 E-value: 5.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 15 AGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSM 94
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 95 MGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIG 174
Cdd:TIGR00711 84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINV 163
|
170 180
....*....|....*....|....*
gi 490283926 175 SVGIL-WVIAWYFIYAENPEEHKRI 198
Cdd:TIGR00711 164 PIGIIvVVVAFFILPRDKPAASENF 188
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
38-416 |
7.62e-11 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 63.34 E-value: 7.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 38 HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSL-LALRLALGVGEA 116
Cdd:cd17352 28 ELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 117 AAYPSNAGIAARWFpDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFiyaenpeehk 196
Cdd:cd17352 108 LIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL---------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 197 rispsevriirdgqkqhhgdktvlpmkwYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLvKEKGMDFIKMGMVAALP 276
Cdd:cd17352 177 ----------------------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSII 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 277 LLCGMVIEVFAGWASDRLVHKKvlsltATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVwaLPGD 356
Cdd:cd17352 228 GISDIVGRILLGLLADKPRIGR-----LYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPV--ILAD 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 357 VAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:cd17352 301 LVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-193 |
1.19e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.58 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 10 IRWWIAGLMWLAIAINYIdrTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWS 89
Cdd:COG2271 180 LRFWLLALAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 90 IATSM--MGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWR 167
Cdd:COG2271 258 AALALllLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|....*.
gi 490283926 168 LTFLIIGSVGILWVIAWYFIYAENPE 193
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
49-415 |
4.67e-10 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 61.57 E-value: 4.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 49 MMGFIMAAFFWSYsllqipagwFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAAR 128
Cdd:TIGR00898 137 FVGVLLGSFVFGY---------LSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 129 WFPDKERATVSGLFDSASKFgGAIAMPLIVWMIYtfDWRLTFLIIGSVGILWVIAWYFIyAENPEEH---KRISPSEVRI 205
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSL-GLVLLPLVAYFIP--DWRWLQLAVSLPTFLFFLLSWFV-PESPRWLisqGRIEEALKIL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 206 IRDGQKqhhgDKTVLPMKWYK------LLRYRNIWAMCIGFFTINYTSYFFITWLPTYlvkekGMDFIKMGMVAALPLLC 279
Cdd:TIGR00898 284 QRIAKI----NGKKLPAEVLSlslekdLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWF-----TTAFSYYGLVLDLGNLG 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 280 GMVIEVFAGWASDRLVHKKVLSLT----ATRKLFLTIGLLMALCIGFAPF--TDSVFMTVFLLCVAKSGTTVAASQVWAL 353
Cdd:TIGR00898 355 GNIYLDLFISGLVELPAKLITLLLidrlGRRYTMAASLLLAGVALLLLLFvpVDLYFLRTALAVLGKFGITSAFQMVYLY 434
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 354 PGDVAPKNSVSIVAGLQNTVSNMGGAVGPIItgaivAATGSFNWAL---IFSAILVVIGIINYLF 415
Cdd:TIGR00898 435 TAELYPTVVRNLGVGVCSTMARVGSIISPFL-----VYLGEKWLFLplvLFGGLALLAGILTLFL 494
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
19-378 |
4.99e-10 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 60.78 E-value: 4.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 19 WLAIAINYIDRTVLSAAAPHLI-DELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGV 97
Cdd:TIGR00886 7 WFGFFLSFLVWFAFSPLAVFLIkDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 98 ATG-FKSLLALRLALGVGEAAAYPSNAgIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTF----------DW 166
Cdd:TIGR00886 87 AVQsYSVLLLIRLFIGIAGGSFASCMP-WISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLifgggqpahlAW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 167 RLTFLiIGSVGILWVIAwyFIYAENPEEHKRISPSEVRIIRDGQKqhhgdktvlpmkwyKLLRYRNIWAMCIgFFTINYT 246
Cdd:TIGR00886 166 GWAFV-IVPAGILLLPA--LLIFFVGADTPPGKPATGKLSFKEAL--------------KVFGNRHTWILAL-LYSVTFG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 247 SYF-FITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTatrklFLTIGLLMALCIGFAPF 325
Cdd:TIGR00886 228 SFLgVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMN-----FLGVAMGAFLVVLGLVS 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 490283926 326 TDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSvSIVAGLQNTVSNMGG 378
Cdd:TIGR00886 303 DGSLAAFIVLFVALFFFAGAGNGSTFALVPHIFRRAT-GAVSGLIGAIGNLGG 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-153 |
5.43e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.76 E-value: 5.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490283926 91 ATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIA 153
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
69-411 |
7.68e-10 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 60.23 E-value: 7.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 69 GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKS--------LLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSG 140
Cdd:cd17369 65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGS 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 141 LFDSASKFGGAIAMPLIVWMIYTFD--------WRLTFLiigsVGILWVIAWYFIYAENPEehkriSPSEVRIIRDGQKQ 212
Cdd:cd17369 145 FPQLGAPVGLLLATGVFLLLSALLSdeaflswgWRIPFL----LSAVLVAVGLYIRLRLEE-----TPVFRRAKEAGQVV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 213 HHGDKTVLPMKWykllryRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASD 292
Cdd:cd17369 216 RAPLVEVLRRHW------RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSD 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 293 RLvhkkvlsltATRKLFLTIGLLMALCIGFAPF----TDSVFMTVFLLCVAKSG-TTVAASQVWALPGDVAPKNSVSIVA 367
Cdd:cd17369 290 RV---------GRRPVYLAGALLAALFAFPFFWlldtGSTWLIVLAAVVVLGVLhGMMYGPQAAFLAELFPTRVRYTGAS 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490283926 368 GLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17369 361 LGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLV 404
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-411 |
1.06e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 17 LMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKK-----GLGLAVAWWSIA 91
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRllilaDLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 92 TSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFL 171
Cdd:cd06173 83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 172 IIGSVGILWVIAWYFIYAENPEEHKRISPSEVRIIRDGqkqhhgdktvlpmkWYKLLRYRNIWAMCIGFFTINYTSYFFI 251
Cdd:cd06173 163 INALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG--------------LRYLRRSPLLRLLLLALALFALLGGALT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 252 TWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltATRKLFLTIGLLMALCIGFAPFTDSVFM 331
Cdd:cd06173 229 VLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---------RRGRLLLIGALLLGLALLVLGLSPSLWL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 332 TVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd06173 300 LLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
236-437 |
1.14e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 236 MCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTAtrklfltigLL 315
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGL---------LL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 316 MALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGsF 395
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-W 150
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 490283926 396 NWALIFSAILVVIGIINYLFLMGKIEPINDKGGKSPVLNAAE 437
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
222-433 |
2.64e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.45 E-value: 2.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 222 MKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPtYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLS 301
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 302 LTAtrklfltigLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVG 381
Cdd:COG2814 80 LGL---------LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 490283926 382 PIITGAIVAATGsFNWALIFSAILVVIGIINYLFLMGKIEPINDKGGKSPVL 433
Cdd:COG2814 151 PLLGGLLADLFG-WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR 201
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-194 |
1.30e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIdrTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:COG2223 206 RFWLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 91 ATSMMGVATG-FKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFdSASKFGGAIAMPLIVWMIY--TFDWR 167
Cdd:COG2223 284 GLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV-GAAGGLGGFLGPLLFGALLdaTGSYT 362
|
170 180
....*....|....*....|....*..
gi 490283926 168 LTFLIIGSVGILWVIAWYFIYAENPEE 194
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
68-416 |
1.94e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 56.13 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 68 AGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLAL---RLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDS 144
Cdd:pfam00083 66 AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 145 ASKFGGAIAMPLIVWMIYTFD---WRLTF---LIIGSVGILWVIAW-----YFIYAENPEEHKRI------SPSEVRIIR 207
Cdd:pfam00083 146 AITFGILLAYIFGLGLNKTSNsdgWRIPLglqLVPALLLIIGLLFLpesprWLVEKGRLEEAREVlaklrgVPDVDRELD 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 208 DGQKQHHGDKTVLPMKWYKLLRYRN------IWAMCigFFTINYTSYFFITWLPTYLVKEKGM--DFIKMGMVAALpllc 279
Cdd:pfam00083 226 EIKDSLEAGQEAEKASWKELFSTKTrrqrllIGVML--QIFQQLTGINAIFYYSTTIFENLGLsdSFLVTIIVGVV---- 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 280 GMVIEVFAGWASDRLVHkkvlsltatRKLFLTIGLLMALC-----IGFAPFTD-----SVFMTVFLLCVAKSGTTVAASQ 349
Cdd:pfam00083 300 NFVFTFIAIFLVDRFGR---------RPLLLLGAAGMAICfvilgIVALLGVSksdwaGIVAIVFIALFIAFFAMGWGPV 370
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490283926 350 VWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:pfam00083 371 PWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFV 437
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
228-428 |
2.04e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 228 LRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKvlsltATRK 307
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRW-----GRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 308 LFLTIG-LLMALCIGFAPFTDS---------VFMTVFLLCVAKSGTTVAasqVWALPGDVAP-KNSVSIVAGLQNTVSNM 376
Cdd:COG2211 82 PWILIGaIPLALSFVLLFTAPDlsptgkliyALVTYLLLGLAYTLVNIP---YSALGAELTPdYEERTRLSSWRFAFAGL 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 377 GGAVGPIITGAIVAATGS------FNWALIFSAILVVIGIINYLFLMGKIEPINDKGG 428
Cdd:COG2211 159 GGLLASVLPPPLVAAFGGdaalgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS 216
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-415 |
2.35e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.79 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 37 PHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALR----LALG 112
Cdd:cd17333 20 PSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMflagLGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 113 VGEAAAYPsnagIAARWFPDKeRATVSGLFDSASKFGGAIAMPLIVWMIYT-FDWRLTFLIIGSVGILWVIAWYFIYAEn 191
Cdd:cd17333 100 ILDTGANT----FVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAILILLTLFP- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 192 PEEHKRISPSEVRiirdgqkqhhgdKTVLPMKwyKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGM 271
Cdd:cd17333 174 ELPSARNPQQSVG------------AFSASAS--RLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 272 VAALPLLCGMVIEVFAGWASDRlvhkkvlsLTATRKLFLTIGLLMALCIGFAPFTDSVFMTV-FLLCVAKSGTTVAAsqV 350
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRR--------IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVaTALLGLFMAALFPT--I 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 351 WALPGDVAPKNSVSIVaGLQNTVSNMGGAVGPIITGAIVAATGSfNWALIFSAILVVIGIINYLF 415
Cdd:cd17333 310 LSLGISNLPYAKGKGT-SVLLAAGSIGGAIIPFIMGFIAEAVGI-QTAMLLITILYAIIFVLALL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
237-436 |
2.57e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 237 CIGFFTINYTSYFFITWLPTYlVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltaTRKLFLTIGLLm 316
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF----------GRKRLLLLGLL- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 317 alCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVW----ALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIItGAIVAAT 392
Cdd:cd17325 70 --LLAVSTLLFAFATSYWQLLLARFLQGLASAAVWpaamALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL-GGLLADA 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 490283926 393 GSFNWALIFSAILVVIGIINYLFLMGKIEPINDKGGKSPVLNAA 436
Cdd:cd17325 147 LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS 190
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
69-339 |
3.39e-08 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 55.38 E-value: 3.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 69 GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKS--------LLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSG 140
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 141 LFDSASKFGGAIAMPLIVWMIYTFD--------WRLTFLIIGSVGIlwVIAWYFIYAENPEEHKRISPSEVRIirdgqkq 212
Cdd:cd17367 141 FQYVTLIGGQLLALGVLLVLQHTLGedqmaawgWRIPFLLGGVLAV--VVLWLRRGLEETESFEAIAESNEAS------- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 213 hhgdktvlPMKWYKLLRYRNIWAMCIGfFTINYTSYF--FITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWA 290
Cdd:cd17367 212 --------AGTLRELRRHPRELLLVVG-LTAGGTLAFytWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRL 282
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 490283926 291 SDRLVHKKVLSLTATRKLFLTIGLLMALcigfaPFTDSVFMTVFLLCVA 339
Cdd:cd17367 283 SDRIGRRPLLLFFGIGGTLATVPLLSAL-----DHTDSPYTAFALVLVG 326
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
47-411 |
3.56e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.91 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 47 PEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKK---------GLGLAVAWwsIATSMMGVATGfksllalRLALGVGEAA 117
Cdd:cd17472 31 PTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPvilfglllfIAGSLLAA--YATSIYGLILG-------RALQGSGAIS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 118 AypsnAGIA--ARWFPDKERA---TVSGLFDSASKFGGAIAMPLIVwMIYTFDWrlTFLIIGSVGIL-WVIAWYFIYaeN 191
Cdd:cd17472 102 S----VVMAllADLTREENRTkamALIGASIGIAFAISMVLGPLLA-AHLGVSG--LFLITAILSLVsLLILLFFVP--D 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 192 PEEHKRISPSEVRIIRdgqkqhhgdktvlpmkwyKLLRYRNIWAMCIGFFTINY--TSYFFItwLPTYLVKEkGMDFIKM 269
Cdd:cd17472 173 PPKIVQISEKEKKKLK------------------KLLKNKRLLRLDFSIFILHFvlMAFFYI--LPLLLTQL-GGGKGQL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 270 GMVaalpLLCGMVIEVFAGWASDRLVHKKvlslTATRKLFLTIGLLMAL-CIGFAPFTDSVFMTVFLLCVAKSGTTVAAS 348
Cdd:cd17472 232 WKV----YLPAILIGFILMVPFVIYAEKK----GKMKQVFVSSILLIAVgFLLLLFAATSLWLLIIGLIIFFIGFNLLEA 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490283926 349 QVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17472 304 LLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLV 366
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
8-411 |
3.95e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 55.47 E-value: 3.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 8 TRIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDP-EMMGFIMAAFF--WSYSLLqipAGWFADRFGQKKGLGLA 84
Cdd:PRK03893 15 NRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTvQAASLISAAFIsrWFGGLL---LGAMGDRYGRRLAMVIS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 85 VAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTF 164
Cdd:PRK03893 92 IVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 165 DWRLTFLIigsvGILWVIAWYFIYAENPEEHKrispsevriIRDGQKQHHGDKTVLPMKWYKLLRYRNIWAMCIGF---- 240
Cdd:PRK03893 172 GWRALFFI----GILPIIFALWLRKNLPEAED---------WKEKHAGKAPVRTMVDILYRGEHRIINILLTLAAAaalw 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 241 --FTINYTSY---------------------------------------FFITW-----LPTYLVKEKGMDfikMGMVAA 274
Cdd:PRK03893 239 fcFAGNLQNAaivavlgllcaaifisfmvqssgkrwptgvmlmvvvlfaFLYSWpiqalLPTYLKTDLGYD---PHTVAN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 275 LPLLCG---MVIEVFAGWASDRLvhkkvlsltATRKLF---LTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAAs 348
Cdd:PRK03893 316 VLFFSGfgaAVGCCVGGFLGDWL---------GTRKAYvcsLLISQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGISG- 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490283926 349 qvwALP---GDVAPKNSVSIVAGLQNTVSNMGGAVGPIItGAIVAATGSFNWALI---FSAILVVIGII 411
Cdd:PRK03893 386 ---LLPkliGGYFDTEQRAAGLGFTYNVGALGGALAPIL-GALIAQRLDLGTALAslsFSLTFVVILLI 450
|
|
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
65-411 |
9.82e-08 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 53.60 E-value: 9.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 65 QIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKeRATVSGLFDS 144
Cdd:TIGR00890 55 MPVGGLLADKFGPRAVAMLGGILYGLGFTFYAIADSLAALYLTYGLASAGVGIAYGIALNTAVKWFPDK-RGLASGIIIG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 145 ASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISpSEVRIirdgqkqhhGDKTVLPMkw 224
Cdd:TIGR00890 134 GYGLGSFILSPLITSVINLEGVPAAFIYMGIIFLLVIVLGAFLIGYPPGQLIKTN-IEVSV---------KDYTVWEM-- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 225 yklLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMViEVFAGWASDRLVHKKVLSLTa 304
Cdd:TIGR00890 202 ---LRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSLGLSDGFLVLAVSISSIFNGGG-RPFLGALSDKIGRQKTMSIV- 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 305 trklfLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVaASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPII 384
Cdd:TIGR00890 277 -----FGISAVGMAAMLFIPMLNDVLFLATVALVFFTWGGT-ISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLI 350
|
330 340
....*....|....*....|....*..
gi 490283926 385 tGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:TIGR00890 351 -ASHALTEIGFEYTFIVTGAFALTSLA 376
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
249-416 |
1.08e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 53.71 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 249 FFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATrkLFLTIGllmalCIGFApFTDS 328
Cdd:cd17471 14 FVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLAL--LAGALG-----YLLFA-FLRN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 329 VFMTVFLLCVAKSGTTVAASQVWALPGDVA----PKNSVSIVAGLQNTVSnMGGAVGPIItGAIVAATGSFNWALIFSAI 404
Cdd:cd17471 86 YWVLLLVGVVLLSLGAAAFPQLFALAREYAdrssGRDATLFNSVLRAAFS-LAWVIGPPL-AFLLLDVLGFTGLFLLAAL 163
|
170
....*....|...
gi 490283926 405 L-VVIGIINYLFL 416
Cdd:cd17471 164 LyLVVALLVLFLL 176
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
30-411 |
1.29e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 53.35 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 30 TVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIAtSMMGVATGFKSLLALRL 109
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAG-ILLRSLGGIALLFLGTA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 110 ALGVGEAAAYPSNAGIAARWFPDKeRATVSGLFDSASKFGGAIAMPLIVWM--IYTFDWRLTFLIIGSVGILWVIAWYFI 187
Cdd:cd17339 95 LAGAGIAVGNVLLPSLIKRDFPRR-VGLMTGLYTTSMNLGAALASGLSVPLaqALGGGWRGALAIWALPALLALLIWLPQ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 188 YAENPEEHKRISPSEVRiirdgqkqhhgdktvlpmkwyKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVkEKGMDFI 267
Cdd:cd17339 174 LRRRKRAAAAAAPLTKI---------------------SVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILI-DAGLSAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 268 KMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTATrkLFLTIGLLMALcigFAPFTDSVFMTVFLLcvakSGTTVAA 347
Cdd:cd17339 232 TAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLA--VLFIIGVLGLL---FAPTALALLWAVLLG----LGGGAAF 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490283926 348 SQVWALPGDVAPknSVSIVAGLQNTVSNMG---GAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17339 303 SLALTLISLRSS--DPAEAAALSGMAQSVGyllAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLV 367
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-417 |
1.45e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 52.99 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 40 IDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKK---GLGLAVAwwSIATSMMGVATGFKSLLALRLALGVGeA 116
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlfiIIGLLFT--VLASLIMILFPSPWGLLIARFLSGIA-A 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 117 AAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMpLIVWMIY-TFDWRLTFLIIGSVGILWVIAWYFIyaENPEEH 195
Cdd:cd17490 100 ATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAF-LIGGLIAeHFGMRAPFLLAALAGVLGFILSLFI--KEERRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 196 KRISPSEVRIIRdgqkqhhgdktvlpmkwyKLLRYRNIWA---MCIGFFTINYTSYFFITwlpTYLVKEKGMDFIKMGMV 272
Cdd:cd17490 177 KKPVLTELKELL------------------SVLKDKKLLFfslLAILQQMITFSTTFGFT---PLIAKQLGASSFQLGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 273 AALPLLCGMVIEVFAGWASDRLVhkkvlsltATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWA 352
Cdd:cd17490 236 SIIYLLPNALASLLSGTLFYKKL--------GERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMS 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 353 LPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILVVIGIINYLFLM 417
Cdd:cd17490 308 LSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-187 |
1.88e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 13 WIAGLMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAA--FFWSYSLLQIpAGWFADRFGQKKGLGLAVAWWSI 90
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGwsVLLALGSLFV-GRLLKKRFGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 91 ATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTF 170
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 490283926 171 LIIGSVGILWVIAWYFI 187
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
53-411 |
2.16e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 52.85 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 53 IMAAFFWSYS---------LLQIPAGWFADRFGQKKGLgLAVAWW--SIATSMMGVATGFKSLLALrLALGVG----EAA 117
Cdd:COG2270 48 AAATALWGYAlaiagllvaLLAPVLGAIADRSGRKKPF-LAFFTLlgVLATAALFFVAPGGLWLGL-LLFVLAnigfEGS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 118 AYPSNA---GIAarwfPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDW----------RLTFLIigsVGILWVI-A 183
Cdd:COG2270 126 LVFYNAflpDIA----TPEEIGRVSGLGWALGYLGGVLLLLINLALFLKPEAfglpdageavRISFLL---TALWWLLfA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 184 WYFIYAeNPEEHKRISPSEVRIIRDGQKQhhgdktvLPMKWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKG 263
Cdd:COG2270 199 LPLFLF-LPERPRPGPAPPRGAVRAGFRE-------LRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 264 MDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLsltatrklFLTIGLLMALCIGfAPFTDSvfMTVFLLCVAKSGT 343
Cdd:COG2270 271 FSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVI--------LVSLVIWIVVCLA-AYFLTT--ALAFWILGLLIGL 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 344 TVAASQV--WALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGII 411
Cdd:COG2270 340 VMGGIQAlsRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLV 409
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
63-409 |
2.21e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 52.80 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 63 LLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMG-VATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKeRATVSGL 141
Cdd:cd17314 53 LTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSyVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 142 FDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIgsvGILWVIAWYFIYAENPEEHKRISpsevriirdGQKQHHGDKTVLP 221
Cdd:cd17314 132 PTTGYSLGLVLGSPLLRILWVFYGLALVYTIL---GILAAIVLSVVSLLGFKEPPDNQ---------ARLHVQKKKTQTM 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 222 MKWYKLLRYRNIWAMCIGFFTINYT-SYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMvievFAGWASDRLVHKKVl 300
Cdd:cd17314 200 GEIFRDKVFWILFIAIFLVLIGGFLfIANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRL----LWGIVADFFGGRLS- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 301 sltaTRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPgDVAPKNSVSIVAGLQNTVSNMGGAV 380
Cdd:cd17314 275 ----TLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVS-TVFGTESFATLYGILLFAPAIGSIL 349
|
330 340
....*....|....*....|....*....
gi 490283926 381 GPIITGAIVAATGSFNWALIFSAILVVIG 409
Cdd:cd17314 350 GPMLGAKFYDRTPSYISAVYIYAVIVFLA 378
|
|
| oxa_formateAnti |
TIGR04259 |
oxalate/formate antiporter; This model represents a subgroup of the more broadly defined model ... |
69-199 |
2.94e-07 |
|
oxalate/formate antiporter; This model represents a subgroup of the more broadly defined model TIGR00890, which in turn belongs to the Major Facilitator transporter family. Seed members for this family include the known oxalate/formate antiporter of Oxalobacter formigenes, as well as transporter subunits co-clustered with the two genes of a system that decarboxylates oxalate into formate. In many of these cassettes, two subunits are found rather than one, suggesting the antiporter is sometimes homodimeric, sometimes heterodimeric.
Pssm-ID: 275086 [Multi-domain] Cd Length: 405 Bit Score: 52.46 E-value: 2.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 69 GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKeRATVSGLFDSASKF 148
Cdd:TIGR04259 59 GWFVDKYGPRIVVMFGGIMCGLGWVLNAYADSLPALYAAAVVAGIGAGAVYGTCVGNALKWFPDK-RGLAAGLTAAGFGA 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 490283926 149 GGAIAMPLIVWMIYTFDWRLTFLIIGSV-GILWVIAWYFIYAENPEEHKRIS 199
Cdd:TIGR04259 138 GAALTVVPIAAMIKVSGYQAAFMYFGLGqGIVIVLLALLLRAPSPGQVPKQA 189
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
229-437 |
3.10e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 229 RYRNIWAMCIGFFtINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltATRKL 308
Cdd:COG2223 3 RWRVLLLATLAFF-LAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF---------GPRRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 309 FLTIGLLMALCIGFAPFTDS--VFMTVFLLCVAKSGTTVAASQvwALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITG 386
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSywLLLLLGLLLGIGGGGSFAVGI--ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 490283926 387 AIVAATGsFNWALIFSAILVVIGIINYLFLMGKIEPINDKGGKSPVLNAAE 437
Cdd:COG2223 151 LLIAAFG-WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE 200
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
14-410 |
3.32e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.92 E-value: 3.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 14 IAGLMWLAIAINyIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATS 93
Cdd:cd06180 1 LAGALALAVAMG-IGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 94 MMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMI-YTFDWRLTFLI 172
Cdd:cd06180 80 AMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLgGGLSWRAGWLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 173 IGSV-GILWVIAWYFIYAEnPEEHKRISPSEVRIIRdgqkqhhgdktvlPMKWYKLLryrniwamcIGFFTINYTSYFFI 251
Cdd:cd06180 160 LALLsAVLLLLSFLLLRRG-PSAPTEASAAESAPGL-------------NRPLWRLA---------LAYGLFGFGYIITA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 252 TWLPTYLVKEKGMDFIkmgmVAALPLLCGMVIeVFAGWASDRLVHKKvlsltATRKLFLTIGLLMALCIGFAPFTDSVFm 331
Cdd:cd06180 217 TFLPLIARETGAGSLL----AGLLWSLFGLAA-VPSCFLWGALSDRW-----GTRRALAANLLVQAVGVLLPLLSPGPA- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 332 tVFLLCVAKSGTTVAA--SQVWALPGDVAPKNSVSIVaGLQNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIG 409
Cdd:cd06180 286 -GLVLSAVLFGGTFMAitALVMALARELAPPAAPRAL-ALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVA 363
|
.
gi 490283926 410 I 410
Cdd:cd06180 364 A 364
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
69-329 |
5.82e-07 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 51.47 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 69 GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKF 148
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 149 GGAIAMPLIVWMIYTFDWRLTFLIigsvGILWVIAWYFIYAENPEEHKRISPSevriIRDGQKQHHGDKTVLPMKWYKLL 228
Cdd:PRK12307 154 GNIIAAYFMPSFAEAYGWRAAFFV----GLLPVLLVIYIRARAPESKEWEEAK----LSGKGKHSQSAWSVFSLSMKGLF 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 229 RYRNIWAMCIGF---FTINYTSYFFITWLPTYLVKEkGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSltat 305
Cdd:PRK12307 226 NRAQFPLTLCVFivlFSIFGANWPIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFS---- 300
|
250 260
....*....|....*....|....
gi 490283926 306 rklfltIGLLMALCIGFAPFTDSV 329
Cdd:PRK12307 301 ------IGLLMSFLFIFPLFRIPQ 318
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-183 |
5.93e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.27 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIdrTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGL-GLAVAWWS 89
Cdd:cd06174 204 GLWLLLLAIFLVNLAYY--SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLlLIGLLLMA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 90 IATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIY-TFDWRL 168
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTG 361
|
170
....*....|....*
gi 490283926 169 TFLIIGSVGILWVIA 183
Cdd:cd06174 362 AFLVLAVLLLLAAIL 376
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-179 |
1.35e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 9 RIRWWIAGLMWLAIAINYidrTVLSAAAP-HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAW 87
Cdd:cd17316 176 RRRTLLLILLWFFISFGY---YGLTTFLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 88 WSIATSMMGVA--TGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFD 165
Cdd:cd17316 253 SGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
170
....*....|....
gi 490283926 166 WRLTFLIIGSVGIL 179
Cdd:cd17316 333 GTGVPALILALLAI 346
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
229-416 |
4.92e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.88 E-value: 4.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 229 RYRNIWAMCIGFFTINYTSYFFITWLPTyLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTatrkl 308
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 309 fLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASqvwALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAI 388
Cdd:COG0477 86 -LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGAL---ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180
....*....|....*....|....*...
gi 490283926 389 VAATGsFNWALIFSAILVVIGIINYLFL 416
Cdd:COG0477 162 VAALG-WRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
225-388 |
5.56e-06 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 48.46 E-value: 5.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 225 YKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTA 304
Cdd:cd17322 279 FRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIG 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 305 TRKLFLTIGLLMALCIGfapfTDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPII 384
Cdd:cd17322 359 VPLYIVGMGLLIRYRGG----SGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAI 434
|
....
gi 490283926 385 TGAI 388
Cdd:cd17322 435 SGAI 438
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
256-417 |
5.76e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.19 E-value: 5.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 256 TYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTAtrklfltigLLMALCIGFAPFTDSVFMTVFL 335
Cdd:cd06174 20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGL---------LLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 336 LCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIV-AATGSFNWALIFSAILVVIGIINYL 414
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAAALALLAAILLL 170
|
...
gi 490283926 415 FLM 417
Cdd:cd06174 171 LVV 173
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
48-417 |
6.75e-06 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 48.08 E-value: 6.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 48 EMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVAT-----GFKSLLALRLALGVGEAAAYPSN 122
Cdd:cd17344 62 ELLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYywnihSLWYFVVVQILAGLFQSTGWPSV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 123 AGIAARWFPDKERATVSGLFDSASKFGGaIAMPLIVWMIYTFDWRLTFLIIGS-VGILWVIAWYFIYAENPeehkrisps 201
Cdd:cd17344 142 VACVGNWFGKGKRGLIMGIWNSHTSVGN-ILGSLIAGIFVSSAWGLSFIVPGIiIAAMGVLVFLFLVEHPP--------- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 202 evriirdgqkqhhgdkTVLPmkwykllryrniWAMCIgFFTiNYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGM 281
Cdd:cd17344 212 ----------------GVIE------------FSLCL-FFA-KLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 282 VIEVFAGWASDRLvhkKVLSLTATRKLFLTI-GLLMALCIGfapfTDSVFMTVFLLCV---------AKSGTTVAAS--Q 349
Cdd:cd17344 262 VGGILAGYISDYT---GGRATTCAAMLILAApMLFIYNYFG----QVSMTTNIVLLIVcgllvngpyALITTAVSADlgT 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 350 VWALPGDVapkNSVSIVAGLQNTVSNMGGAVGPIITGAIvaatGSFNWALIFSaILVVIGIINYLFLM 417
Cdd:cd17344 335 HKSLKGNA---RALATVTAIIDGTGSIGAALGPLLAGLI----SSRGWNNVFY-MLIAADVCAGLLLT 394
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
14-187 |
1.59e-05 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 46.76 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 14 IAGLMWLAIAINYIdrtVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATS 93
Cdd:cd17372 3 YAGMGWVAEAMEMM---LLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 94 MMGVATGFKSLLALRLALGVGeAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLII 173
Cdd:cd17372 80 LSAFAPNYMWLIILRCLVGLG-LGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFS 158
|
170
....*....|....
gi 490283926 174 GSVGILWVIAWYFI 187
Cdd:cd17372 159 SVPSSLLLVFYRWT 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
42-411 |
2.25e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 42 ELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGL---GLAVAwwSIATSMMGVATGFKSLLALRLALGVGEAAA 118
Cdd:cd17370 28 VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvilGYGLS--ALAKPLLALAGSWQLVLLLRILERLGKGIR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 119 YPSNAGIAARWFPDKERATVSGL---FDSASKFGGAIAMPLIVWmIYTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEH 195
Cdd:cd17370 106 TPPRDALLADATPPSGRGKAFGLhraLDTLGAVLGPLLAALLLY-LLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 196 KRISpsevriirdgqKQHHGDKTVLPmkwYKLLRYRNIWAmcigFFTINYTSYFFITwlptYLVKEKGMDFIKMGMVAAL 275
Cdd:cd17370 185 KLRK-----------KSKKTSLKKLP---KAFWLYLLAVA----LFALGNFSFAFLI----LRAQELGLSAALIPLLYAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 276 PLLCGMVIEVFAGWASDRLVHKKVlsltatrkLFLTIGLLMALCIGFApFTDSVFMTVFLLCVAKSGTTVAASQVWALPG 355
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKL--------LILGYLSLALAYLGFA-LGSSLWLLLLGFILWGLYMGAQESIERAAVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490283926 356 DVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIvAATGSFNWALIFSAILVVIGII 411
Cdd:cd17370 314 DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL-WDLISPSAAFLFSAVLALIALL 368
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
17-172 |
2.33e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 46.64 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 17 LMWLAIAInyiDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMG 96
Cdd:PRK14995 13 LVYIPVAI---DATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAA 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 97 VATGFKSLLALRLALGVGEAAAYPSN-AGIAARWFPDKERATVSGLFdSASKFGGAIAMPLIVWMIYT-FDWRLTFLI 172
Cdd:PRK14995 90 FSPTASWLIATRALLAIGAAMIVPATlAGIRATFTEEKQRNMALGVW-AAVGSGGAAFGPLVGGILLEhFYWGSVFLI 166
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
68-187 |
2.84e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.03 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 68 AGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDsask 147
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFG---- 120
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 490283926 148 FGGAIAMPLIVWMIYTF-DWRLTFLIIGSVGILWVIAWYFI 187
Cdd:cd17317 121 LFWALGYMLLALLAYLIrDWRWLQLAISLPGLLFLLLLWWL 161
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
26-372 |
3.56e-05 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 45.81 E-value: 3.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 26 YIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKS-- 103
Cdd:PRK09556 42 YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSvs 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 104 ---LLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVW-MIYTFDWRLT--FLIIGSVG 177
Cdd:PRK09556 122 lglMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWgANYFFDGHVIgmFIFPSIIA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 178 ILWVIAWYFIYAENPEEHKRISPSEvrIIRDGQKQHHGDKTVLPM-KWYKLLRY--RN--IWAMCIGFFTINYTSYFFIT 252
Cdd:PRK09556 202 LIIGFIGLRYGSDSPEELGWGKAEE--IFGEPISEEDKETESTDMtKWQIFVEYvlKNpvIWLLCFANIFLYIVRIGIDN 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 253 WLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKvlSLTATRKLFLTIgllmaLCIGFAPFTDSVFMT 332
Cdd:PRK09556 280 WSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRR--ALVACIALALII-----FTLGVYQHATSEYMY 352
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490283926 333 VFLLCVAksGTTVAASQVW---ALPGdVAPKNSVSIVAGLQNT 372
Cdd:PRK09556 353 LASLFAL--GFLVFGPQLLigvAAVG-FVPKKAIGVANGIKGT 392
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
69-416 |
6.13e-05 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 45.04 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 69 GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKS--------LLALRLALGVGEAAAYPSNAGIAARWFPDKERA-TVS 139
Cdd:cd17366 61 GPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigvwapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGfLGS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 140 GL-FDSASKF-GGAIAMPLIVWMI-----YTFDWRLTFLIIGSVGIlwvIAWYFiyaenpeehkrispsevriirdgqkq 212
Cdd:cd17366 141 WLeFGTLAGFiLGAGLVTLLTLLLteaqmLDWGWRIPFLIAAPLGL---VGLYL-------------------------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 213 hhgdktvlpmkwykllryRNIWAMCIGFFTI-NYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWAS 291
Cdd:cd17366 192 ------------------RRPLLICIGLVLVfNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 292 DRLVHKKVLSLTATRKLFLTIG--LLMALCIGFAPFTDSVFMTVFLLCvaksgttVAASQVWALPGDVAPKNSVSIVAGL 369
Cdd:cd17366 254 DRVGRKPVYAAGLAGLLVLAVPafLLMNSGSIAAIFIGLLVLGLLLSC-------YTATMASTLPALFPTHVRYSALAIA 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 490283926 370 QNTVSNMGGAVGPIITGAIVAATGSFNWALIFSAILVVIGIINYLFL 416
Cdd:cd17366 327 FNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGLVAVLFL 373
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
30-417 |
7.91e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.49 E-value: 7.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 30 TVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRL 109
Cdd:cd17323 16 SIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 110 ALGVGEAAAYPSNAGIAARWFPDKERATVSGLFdSASKFGGAIAMPLI-VWMIYTFDWRLTF--LIIGSvGILWVIAWYF 186
Cdd:cd17323 96 LQGFFGSSPLAIGAGTIADLFTPEERGKAMGVY-SLGPLLGPALGPIIgGFITQSLGWRWIFwfLAIIS-GFCLILIFLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 187 iyaenpeehkrispsevriirdgqkqhhgdktvLPMkwykllryrnIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDF 266
Cdd:cd17323 174 ---------------------------------LPI----------VLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 267 IKMGmVAALPLLCGMVIEVFAG-----WASDRLVHKKVLSLTATRKL--------FLTIGLLM-ALCIGF-----APFTD 327
Cdd:cd17323 211 GEVG-LMYLPIGIGALIGSIIGgrlsdYYYRRLKKKNGGKPEPEARLppafigafLFPIGLFIfGWTIYPhihwiVPIIG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 328 SVFMTVFLLCVAKSGTTVAAsqvwalpgDVAPKNSVSIVAGLqNTVSNMGGAVGPIITGAIVAATGsFNWAL-IFSAILV 406
Cdd:cd17323 290 SAFFGFGLMLIFQSSLTYLV--------DSYPKYAASALAAN-TLVRSIFAAIFPLFAQPMFNNLG-VGWAFtLLAFISL 359
|
410
....*....|.
gi 490283926 407 VIGIINYLFLM 417
Cdd:cd17323 360 AMIPIPFIFYK 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-154 |
8.05e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 8.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 17 LMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKK---GLGLAVAWWSIATS 93
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490283926 94 MMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAM 154
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
14-167 |
1.36e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 44.03 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 14 IAGLMWLAIAInyiDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATS 93
Cdd:cd17441 3 LTGLAWMADAM---EMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGI 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490283926 94 MMGVATGFKSLLALRLALGVGEAAAyPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWR 167
Cdd:cd17441 80 LSAFAPIYSWILVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWR 152
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-198 |
1.68e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 14 IAGLMWLAIAInyidrtVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATS 93
Cdd:COG2211 236 AYLLFFLALAL------VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 94 MMGVA--TGFKSLLALRLALGVGEAAAYPSNAGIAA------RWFPDKERA-TVSGLFDSASKFGGAIAMPLIVWMI--- 161
Cdd:COG2211 310 LLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdydEWKTGRRREgLYFGIFTFAIKLGQALAGALAGLLLalf 389
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 490283926 162 -----------YTFDWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRI 198
Cdd:COG2211 390 gyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEI 437
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
250-439 |
1.72e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 250 FITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLvhkkvlsltaTRKLFLTIGLLM-ALCIGFAPFTDS 328
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRK----------PRRYLLPLGPLLtGLGLSLLGFAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 329 VFMTVFLLCVAKSGTTVAASQVWALPGDVAPKN-----SVSIVAGlqntvsNMGGAVGPIITGAIVAATGSFNWaLIFSA 403
Cdd:cd17478 84 YWLLLLLVALAGIGSAAFHPEGARLASQAAGGRrglamSIFSVGG------NLGFALGPLIAAALVALFGGLGL-LILLI 156
|
170 180 190
....*....|....*....|....*....|....*.
gi 490283926 404 ILVVIGIINYLFLMGKIEPINDKGGKSPVLNAAEQH 439
Cdd:cd17478 157 IPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKG 192
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
269-416 |
2.28e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 269 MGMVAALPLLCGMVIEVFAGWASDRLVHKKVLSLTatrkLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAAS 348
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILA----DLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490283926 349 QVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILVVIGIINYLFL 416
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLLFI 178
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-161 |
3.21e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.73 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 17 LMWLAIAINYIDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMG 96
Cdd:TIGR00895 254 LLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGS 333
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490283926 97 VATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMI 161
Cdd:TIGR00895 334 TLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
11-411 |
3.88e-04 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 42.49 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 11 RWWIAGLMWLAIAINYIDRTVLSAAAPhLIDELKlDPEMMGFIMAAFFWSY-----SLLQIPAGWFADRFGQKKGLGLAV 85
Cdd:PRK09705 4 KFPLNFMLLVLVLIGLNMRPLLTSVGP-LLPQLR-QASGMSFSVAALLTALpvvtmGGLALAGSWLHQHVSERRSVAISL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 86 AWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPdKERATVSGLFDSASKFGGAIAMPLIVWMI-YTF 164
Cdd:PRK09705 82 LLIAVGALMRELYPQSALLLSSALLGGVGIGIIQAVMPSVIKRRFQ-QRTPLVMGLWSAALMGGGGLGAAITPWLVqHSE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 165 DWRLTFLIIGSVGILWVIAWYFIYAENPEEHKRISPSEVRIIRdgqkqhhgdktvlpmkwykllrYRNIWAMCIGFFTIN 244
Cdd:PRK09705 161 TWYQTLAWWALPAVVALFAWWWQSAREVASSHKTTTTPVRVVF----------------------TPRAWTLGVYFGLIN 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 245 YTSYFFITWLPTYLVkEKGMDFIKMGMVAALpLLCGMVIEVFAGWAsdrlvhkkvLSLTATRKLFLTIGLLMALC--IGF 322
Cdd:PRK09705 219 GGYASLIAWLPAFYI-EIGASAQYSGSLLAL-MTLGQAAGALLMPA---------MARHQDRRKLLMLALVLQLVgfCGF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 323 APFTDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNtVSNMGGAVGPIITGAIVAATGSFNWALIFS 402
Cdd:PRK09705 288 IWLPLQLPVLWAMVCGLGLGGAFPLCLLLALDHSVQPAIAGKLVAFMQG-IGFIIAGLAPWFSGVLRSISGNYLMDWAFH 366
|
....*....
gi 490283926 403 AILVVIGII 411
Cdd:PRK09705 367 ALCVVGLMI 375
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
8-294 |
4.23e-04 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 42.39 E-value: 4.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 8 TRIRWWIAGLMWLAIAINYIDRTVLSAAAPHLIDElKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGL--GLAV 85
Cdd:PRK11273 24 RRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLpaGLIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 86 AwwSIATSMMGVATGFKSLLALRLAL----GVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPL-IVWM 160
Cdd:PRK11273 103 A--AAVMLFMGFVPWATSSIAVMFVLlflcGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfLLGM 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 161 IYTFDWRLTFLIIGSVGILWVIAWYFIYAENP--------EEHKRISPSevriirDGQKQHHGDKTVLPMKWYKLLRYRN 232
Cdd:PRK11273 181 AWFNDWHAALYMPAFAAILVALFAFAMMRDTPqscglppiEEYKNDYPD------DYNEKHEQELTAKQIFMQYVLPNKL 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490283926 233 IWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRL 294
Cdd:PRK11273 255 LWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKV 316
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
38-300 |
9.89e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.99 E-value: 9.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 38 HLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIAT--SMMGVATGFKSLLALRLALGVGe 115
Cdd:cd17471 22 FLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGylLFAFLRNYWVLLLVGVVLLSLG- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 116 AAAYP---SNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGIL-WVIAWYFIyaen 191
Cdd:cd17471 101 AAAFPqlfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVvALLVLFLL---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 192 PEEHKRISPSEVRIIRDGQKQHhgdktvlpmkwykllryRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGM 271
Cdd:cd17471 177 PSVKPPAQKATPASSLVKAPVN-----------------RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL 239
|
250 260
....*....|....*....|....*....
gi 490283926 272 VAALPLLCGMVIEVFAGWASDRLVHKKVL 300
Cdd:cd17471 240 LFGLAAALEIPIMLLAGLLAKRFGKRRLL 268
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
34-187 |
1.05e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.09 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 34 AAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGV 113
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490283926 114 GEAAAYPSNAGIAARWF-PDKERATVSGLFDSASKFG---GAIAMPLIVWMIYtfdWRLTFLIIG-SVGILWVIAWYFI 187
Cdd:cd17476 99 GPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGfalGGVFGGLFAQLAW---WPWIFWFLAiLAAIVAVAAIFWT 174
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
13-184 |
3.19e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 13 WIAGLMWLAIAINYIDRTVLSAAAphliDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIAT 92
Cdd:cd17370 203 WLYLLAVALFALGNFSFAFLILRA----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 93 SMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLI 172
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
170
....*....|..
gi 490283926 173 IGSVGILWVIAW 184
Cdd:cd17370 359 SAVLALIALLLL 370
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
106-416 |
3.53e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.51 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 106 ALRLALGVGEAAAYPSNAGIAARWFPDkERATVSGLFDSASKFGGAIAMPLIVWMIYTFDWRLTFLIIGSVGILWVIAWY 185
Cdd:cd17385 99 LVRIVEAVGFAAFITASFAIIAKEFPN-NIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNM 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 186 FIYAENPEEHKRISPSevriirdgqkqhhgdktvlpmkWYKLLRYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKgmd 265
Cdd:cd17385 178 FILPRYDDDPSPKSGS----------------------MLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFK--- 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 266 fIKMGMVAALPLLCGMVIEVFA---GWASDRLVHkkvlsltatRKLFLTIGLLMA----LCIG---FAPFTDSVFMTVFL 335
Cdd:cd17385 233 -LSPGQVGLMFLILAGSYAISAplwGWLSDKKKI---------PKWLMVIGSIITgvgfLLLGpapLLPIKSELWMVIIG 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 336 LCVakSGTTVAASQVWALPG--DVAPKNSVS-------IVAGLQNTVSNMGGAVGPIITGAIVAATGsFNW-ALIFSAIL 405
Cdd:cd17385 303 LVL--LGLSLGAALVPTFPEllNCAREYGFPdnlstygLVSGLFNAAFSLGAFIGPTLGGFLLERLG-FEWaATIQAGLA 379
|
330
....*....|.
gi 490283926 406 VVIGIINYLFL 416
Cdd:cd17385 380 FVVGILMSIYY 390
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
37-411 |
3.72e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 39.13 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 37 PHLIDELKLDPEMMGFIMAAffwsYSLLQI---P-AGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALG 112
Cdd:cd17390 20 STHIRSLGASPTVIGLIGSV----YGALQLfssPlVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 113 VGEAAAYPSNAGIAARwFPDKERATVSGLFDSASKFgGAIAMPLI--VWMIYTFDWRLTFLIIGSVGIL-WVIAWYFiya 189
Cdd:cd17390 96 IFKHTQSLCKAYLSDL-VSEQERSRVLGRFNAASSL-GFILGPVVggHLAETDGGFYYVALLCSAIFILnAGLVWFL--- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 190 enpeehkrisPSEVRIIRdgqkqhhgdktvlpmkwykLLRYrniwamCIGFFTINYTSYFFITWLPTYLVKEKGMDFIK- 268
Cdd:cd17390 171 ----------LSKLWDLL-------------------LVRF------LMGFSVLLFRSNFSLYLEERFDLSPKTIGYLIs 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 269 -MGMVAALpllcgmvievfAGWASDRLvhkKVLSLTATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAA 347
Cdd:cd17390 216 ySGVLGAL-----------SGFLVGRI---LKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLR 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490283926 348 SQVWALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGaiVAATGSFNWALIFSAILVVIGII 411
Cdd:cd17390 282 TCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSG--LLQEFSVSGPGLLGAVLALAAIL 343
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
37-86 |
4.49e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 39.13 E-value: 4.49e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 490283926 37 PHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKG--LGLAVA 86
Cdd:cd17394 23 PQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGilLGLGLY 74
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
69-407 |
4.62e-03 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 38.93 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 69 GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATVsGLFDSASKF 148
Cdd:cd17410 55 PWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGGLGIAIIQALVPGLIKRRFPARVPLAM-GLYSASLMA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 149 GGAIAMPLIVWMIYTFD-WRLTFLIIGSVGILWVIAWYfiyaenpeehkRISPSEVRiirdgqkQHHGDKTVLpmkwyKL 227
Cdd:cd17410 134 GGGLAASLSPRLAQHSAgWQLGLGIWAVPALVALVLWW-----------RQPPREVA-------PSDTAGPGV-----RF 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 228 LRYRNIWAMCIGFFTIN--YTSyfFITWLPTYlvkekgmdFIKMGMVA--ALPLLCGMVI-EVFAGWASDRLVHKkvlSL 302
Cdd:cd17410 191 FRNRRAWLLALYFGLINagYTS--MIAWLPAY--------YLELGWSAqdSGSLLGFMTIfQVLGALVMPALARR---SA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 303 TATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPGDVAPKNSVSIVAGLQNtVSNMGGAVGP 382
Cdd:cd17410 258 DRRPLLMGALAAQLAGFLGLILMPQSLPLLWVALIGLGLGACFSLGLILALDHLRKPRAAGQLAAFVQG-IGFIITGISP 336
|
330 340
....*....|....*....|....*
gi 490283926 383 IITGAIVAATGSFNWALIFSAILVV 407
Cdd:cd17410 337 WIAGWLRDSTGSFQAAWLLLAASVV 361
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
65-162 |
5.24e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 38.80 E-value: 5.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 65 QIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATG------FKSLLALRLALGVGEAAAYPSNAGIAARWFPDKERATV 138
Cdd:cd17364 56 QLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGAL 135
|
90 100
....*....|....*....|....*.
gi 490283926 139 SGLFDSASKFGG--AIAMPLIVWMIY 162
Cdd:cd17364 136 IAAVFAMQGFGIlaGAIVTLILSAIF 161
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-411 |
6.61e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 43 LKLDPEMMGFIMAaffwSYSLLQIPA----GWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAA 118
Cdd:cd17330 29 LGASGYYVGLLQS----SYSLGQFLAsplwGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 119 YPSNAGIAARwFPDKERATVSGLFDSASKFGGAIAmPLIVWMIYT-FDWRLTFLIIGSVGILWVIAWYFIyaenpeehkr 197
Cdd:cd17330 105 SVAQAYIADI-TDEEERAKAFGIISAAFGLGFILG-PALGGFLSTpYGYALPFLVAAALALLNLVLVLFF---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 198 ispsevriirdgqkqhhgdktvlpmkwykllrYRNIWAMCIGFFTINYTSYFFITWLPTYLVKEKGMDFIKMGMVAALPL 277
Cdd:cd17330 173 --------------------------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 278 LCGMVIEVFagwasdrlVHKKVLSLTATRKLFLTIGLLMALCIGFAPFTDSVFMTVFLLCVAKSGTTVAASQVWALPGDV 357
Cdd:cd17330 221 IAGILAQLL--------LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 490283926 358 APKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGsFNWALIFSAILVVIGII 411
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG-PGVPFLLAAGLLLIALF 345
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
1-120 |
6.96e-03 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 38.56 E-value: 6.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 1 MNTTANTTRIRWWIAGLMWLAIAInyiDRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKG 80
Cdd:PRK10504 1 MTDLPDSVRWQLWIVAFGFFMQSL---DTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNI 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 490283926 81 LGLAVAWWSIATSMMGVATGFKSLLALRLALGVGEAAAYP 120
Cdd:PRK10504 78 FFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVP 117
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
28-118 |
7.22e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 28 DRTVLSAAAPHLIDELKLDPEMMGFIMAAFFWSYSLLQIPAGWFADRFGQKKGLGLAVAWWSIATSMMGVATGFKSLLAL 107
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
90
....*....|.
gi 490283926 108 RLALGVGEAAA 118
Cdd:cd17359 96 RIIGGLAVGGA 106
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
254-416 |
9.19e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 37.98 E-value: 9.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 254 LPTYLVKEKGMDFIKMGMVAALPLLCGMVIEVFAGWASDRLVHKKVLsltatrklFLTIgLLMALCIGFAPFTDSVFMTV 333
Cdd:cd17390 18 LLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVL--------LICL-LLTALGYVLLGFSTSLALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490283926 334 FLLCVA---KSGTTVAAsqvwALPGDVAPKNSVSIVAGLQNTVSNMGGAVGPIITGAIVAATGSFNW-ALIFSAILVVIG 409
Cdd:cd17390 89 LSRIPLgifKHTQSLCK----AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYvALLCSAIFILNA 164
|
....*..
gi 490283926 410 IINYLFL 416
Cdd:cd17390 165 GLVWFLL 171
|
|
| |
