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Conserved domains on  [gi|490286043|ref|WP_004181835|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Enterobacteriaceae]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007547)

type II toxin-antitoxin (TA) system RelE/ParE family toxin similar to Vibrio cholerae HigB-1, which inhibits translation by cleavage of mRNA and is the toxin component of the HigB-1/HigA-1 TA module that has been shown to stabilize plasmids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HigB COG3549
Plasmid maintenance system killer protein [Defense mechanisms];
2-100 4.06e-17

Plasmid maintenance system killer protein [Defense mechanisms];


:

Pssm-ID: 442770  Cd Length: 92  Bit Score: 69.76  E-value: 4.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490286043   2 IHSFEEKNLEKLFTSGKSqSGLPTDITNSLKRALNELHAAGSEADLIRLKSRNYEKIHHTRlrererAGdMSSIRVSSKY 81
Cdd:COG3549    1 IKSFKDKGLERFFEGGRT-KGIPADIARKLRRKLDMLDAATSLEDLRVPPGNRLEALKGDR------KG-QYSIRVNGQW 72

                         90
                 ....*....|....*....
gi 490286043  82 RLLFTWANGGANRVKLTAH 100
Cdd:COG3549   73 RICFRWEDGDAEDVEIVDY 91
 
Name Accession Description Interval E-value
HigB COG3549
Plasmid maintenance system killer protein [Defense mechanisms];
2-100 4.06e-17

Plasmid maintenance system killer protein [Defense mechanisms];


Pssm-ID: 442770  Cd Length: 92  Bit Score: 69.76  E-value: 4.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490286043   2 IHSFEEKNLEKLFTSGKSqSGLPTDITNSLKRALNELHAAGSEADLIRLKSRNYEKIHHTRlrererAGdMSSIRVSSKY 81
Cdd:COG3549    1 IKSFKDKGLERFFEGGRT-KGIPADIARKLRRKLDMLDAATSLEDLRVPPGNRLEALKGDR------KG-QYSIRVNGQW 72

                         90
                 ....*....|....*....
gi 490286043  82 RLLFTWANGGANRVKLTAH 100
Cdd:COG3549   73 RICFRWEDGDAEDVEIVDY 91
HigB-like_toxin pfam05015
RelE-like toxin of type II toxin-antitoxin system HigB; This family carries several different ...
 4-102 4.94e-08

RelE-like toxin of type II toxin-antitoxin system HigB; This family carries several different examples of type II bacterial toxins of toxin-antitoxin systems including many HigB-like ones. The fold is referred to as the RelE/YoeB/Txe/Yeeu fold suggesting all examples of these are present in this family. Several plasmids with proteic killer gene-systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of these systems results in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.


Pssm-ID: 398609  Cd Length: 93  Bit Score: 46.35  E-value: 4.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490286043    4 SFEEKNLEKLFTSGKSQSGLPTDITNSLKRALNELHAAGSEADLIRLKSRNYEKIHhtrlrereraGDMS---SIRVSSK 80
Cdd:pfam05015   2 SFRDKGLERFFEDGDTHRKIQSGLAKVLRRKLQAIDAAEDERDLRAPPGNHLEKLK----------GDLKghySIRVNGQ 71

                          90       100
                  ....*....|....*....|..
gi 490286043   81 YRLLFTWANGGANRVKLTAHAH 102
Cdd:pfam05015  72 YRLIFYFKAEDADTVNLYVDYH 93
 
Name Accession Description Interval E-value
HigB COG3549
Plasmid maintenance system killer protein [Defense mechanisms];
2-100 4.06e-17

Plasmid maintenance system killer protein [Defense mechanisms];


Pssm-ID: 442770  Cd Length: 92  Bit Score: 69.76  E-value: 4.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490286043   2 IHSFEEKNLEKLFTSGKSqSGLPTDITNSLKRALNELHAAGSEADLIRLKSRNYEKIHHTRlrererAGdMSSIRVSSKY 81
Cdd:COG3549    1 IKSFKDKGLERFFEGGRT-KGIPADIARKLRRKLDMLDAATSLEDLRVPPGNRLEALKGDR------KG-QYSIRVNGQW 72

                         90
                 ....*....|....*....
gi 490286043  82 RLLFTWANGGANRVKLTAH 100
Cdd:COG3549   73 RICFRWEDGDAEDVEIVDY 91
HigB-like_toxin pfam05015
RelE-like toxin of type II toxin-antitoxin system HigB; This family carries several different ...
 4-102 4.94e-08

RelE-like toxin of type II toxin-antitoxin system HigB; This family carries several different examples of type II bacterial toxins of toxin-antitoxin systems including many HigB-like ones. The fold is referred to as the RelE/YoeB/Txe/Yeeu fold suggesting all examples of these are present in this family. Several plasmids with proteic killer gene-systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of these systems results in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.


Pssm-ID: 398609  Cd Length: 93  Bit Score: 46.35  E-value: 4.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490286043    4 SFEEKNLEKLFTSGKSQSGLPTDITNSLKRALNELHAAGSEADLIRLKSRNYEKIHhtrlrereraGDMS---SIRVSSK 80
Cdd:pfam05015   2 SFRDKGLERFFEDGDTHRKIQSGLAKVLRRKLQAIDAAEDERDLRAPPGNHLEKLK----------GDLKghySIRVNGQ 71

                          90       100
                  ....*....|....*....|..
gi 490286043   81 YRLLFTWANGGANRVKLTAHAH 102
Cdd:pfam05015  72 YRLIFYFKAEDADTVNLYVDYH 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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